Histologic and Immunohistochemical Identification of Cribriform Adenocarcinoma

Publication date: Available online 4 April 2017
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Rashidah Wiley, Aditya Kalgi, Renee Reich, Paul Freedman
ObjectiveTo assess whether tumors originally classified as adenocarcinoma NOS (Adca-NOS), adenoid cystic carcinoma (ACC) and polymorphous low-grade adenocarcinoma (PLGA) could be reclassified as cribriform adenocarcinoma of the tongue and minor salivary gland (CATMSG).Study DesignTumors diagnosed between 1992 and 2014 at Oral Pathology Laboratory, Inc. (NYHQ) were selected. Each tumor was reviewed by 3 oral pathologists to confirm the diagnosis of CATMSG. After review, 11/70 Adca-NOS, 5/38 ACCs, and 5/23 PLGAs met the histological criteria of CATMSG. One case diagnosed as CATMSG in 2014 was used as a control and the following stains were completed: EMA, HBME-1(Hector Battifora Mesothelial-1), p16, and CAM 5.2. 11-Adca, NOS, 2ACCs (tissue was available for only 2 of the 5 adenoid cystic carcinoma cases), and 5-PLGAs underwent immunohistochemical (IHC) staining. Positive HMBE-1, p16 and CAM 5.2 staining along with negative staining for EMA were considered supportive of a diagnosis of CATMSG.ResultsBased on histologic features and IHC results, we were able to reclassify 10 tumors (8 Adca-NOS and 2-PLGA) as CATMSG.ConclusionCATMSG should be from distinguished from other salivary gland tumors with similar histologic features. The diagnosis of CATMSG can be made on H&E alone; but IHC analysis can be useful for confirmation.



http://ift.tt/2nQ0jlE