The impact of marital status at diagnosis on cancer survival in patients with differentiated thyroid cancer
Abstract Previous studies have revealed that marital status influences the prognosis of patients with various types of cancer. We evaluated the influence of marriage on the survival outcomes in differentiated thyroid cancer (DTC). The Surveillance, Epidemiology and End Results (SEER) database between 2002 and 2012 was used to compare cancer-specific mortality in different marital status, and in each sex, age, and stage stratification by multivariate Cox regression model. In total, 61,077 eligible patients were identified. The widowed group had the highest proportion of women, elder... περισσότερα »
Genetic alterations of differentiated thyroid carcinoma in iodine-rich and iodine-deficient countries
Abstract *BRAF V600E* mutation, *RET* rearrangements, and *RAS* mutations are the common genetic alterations in differentiated thyroid carcinomas derived from follicular thyroid cells. However, the relationship between these alterations and iodine intake is still controversial. To clarify the influence of iodine intake on the occurrence of differentiated thyroid carcinomas, we performed molecular analyses for two differentiated carcinomas, papillary thyroid carcinomas (PTCs) and follicular thyroid carcinomas (FTCs), from an iodine-rich country (Japan) and an iodine-deficient count... περισσότερα »
Sorafenib treatment in children with relapsed and refractory neuroblastoma: an experience of four cases
Abstract Metastatic neuroblastoma is an aggressive malignancy with a poor prognosis. Recent findings have shown that sorafenib decreases cell viability and increases apoptosis in human neuroblastoma cell lines. We report an experience of compassionate use of sorafenib in children with treatment-refractory neuroblastoma. Sorafenib showed transient anti-tumor activity in all four patients without adverse effects. However, progression was observed after a short stabilization phase. While sorafenib showed minimal anti-tumor activity in our patients, it might still be effective in pati... περισσότερα »
Incidence and long-term outcome of postradiotherapy moyamoya syndrome in pediatric patients with primary brain tumors: a single institute experience in Taiwan
Abstract We aimed to investigate the incidence and long-term outcome of moyamoya syndrome in pediatric patients with primary brain tumors after receiving cranial radiotherapy (RT) in a single institute in Taiwan. The complete medical records, medical images, and RT notes of 391 pediatric patients with primary brain tumors treated with cranial RT between January 1975 and December 2005 in Taipei Veterans General Hospital (TVGH), Taiwan, were entered into an electronic registry and reviewed. Eight (2%) cases of post-RT moyamoya syndrome were identified in the sample of 391 patients. ... περισσότερα »
Effects of propolis and gamma-cyclodextrin on intestinal neoplasia in normal weight and obese mice
Abstract Obesity is associated with colorectal cancer (CRC). This effect might be attributed to adipokine-supported signaling. We have established that propolis suppresses survival signaling in CRC cells *in vitro*; therefore, we ascertained the ability of a propolis supplement to modulate intestinal neoplastic development in C57BL/6J-*ApcMin/+*/J mice in the lean and obese state. To induce obesity, mice were fed with a Western diet containing 40% fat. Since the propolis supplement includes gamma-cyclodextrin, the interventions included diets supplemented with or without gamma-cyc...περισσότερα »
Study Skills Inventory among Medical Students of Private and Government Medical Colleges in South India
2016-06-05T20-22-43Z *Source:* International Journal of Community Medicine and Public Health praveen kulkarni, kavitha HS, Chinmaye Melur, Siddalingappa hugar, renuka manjunath. Background: Study skills are discrete techniques that can be learned, usually in a short time, and applied to all or most fields of study. The approach students choose appears to be a central factor in determining both the quality and quantity of their learning. Learning styles influence the maintenance of information and the depth of understanding. Methods: A prospective interventional study was conducted a... περισσότερα »
Inappropriate statistical method in a parallel-group randomized controlled trial results in unsubstantiated conclusions
The conclusions of Cassani et al. in the January 2015 issue of Nutrition Journal (doi:10.1186/1475-2891-14-5) cannot be substantiated by the analysis reported nor by the data themselves. The authors ascribed the observed decrease in inflammatory markers to the components of flaxseed and based their conclusions on within-group comparisons made between the final and the baseline measurements separately in each arm of the randomized controlled trial. However, this is an improper approach and the conclusions of the paper are invalid. A correct analysis of the data shows no such effect...περισσότερα »
A feasibility study of implementing grip strength measurement into routine hospital practice (GRImP): study protocol
Background: Handgrip strength is a non-invasive marker of muscle strength, and low grip strength in hospital inpatients is associated with poor healthcare outcomes including longer length of stay, increased functional limitations, and mortality. Measuring grip strength is simple and inexpensive. However, grip strength measurement is not routinely used in clinical practice. The aim of this study is to evaluate the feasibility of implementing grip strength measurement into routine clinical practice.Methods/designThis feasibility study is a mixed methods design combining qualitative,... περισσότερα »
Effectiveness of management interventions for control of invasive Common ragweed Ambrosia artemisiifolia: a systematic review protocol
Background: Alien species are severely impacting the environment, public health and socioeconomy at a global scale. Their management is thus of crucial importance and the subject of intensive research efforts. Common ragweed Ambrosia artemisiifolia L. is an alien species with negative impacts on agriculture, human health and biodiversity. It is a highly allergenic, wind-pollinated herb native to North America that was first introduced to Europe during the seventeenth century. It has since become widespread and is currently in an ongoing phase of rapid spread and increasing abundan... περισσότερα »
Microenvironmental Control of Adipocyte Fate and Function
Publication date: Available online 4 June 2016 *Source:*Trends in Cell Biology Author(s): Benjamin D. Pope, Curtis R. Warren, Kevin Kit Parker, Chad A. Cowan The properties of tissue-specific microenvironments vary widely in the human body and demonstrably influence the structure and function of many cell types. Adipocytes are no exception, responding to cues in specialized niches to perform vital metabolic and endocrine functions. The adipose microenvironment is remodeled during tissue expansion to maintain the structural and functional integrity of the tissue and disrupted remodel... περισσότερα »
Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network
Publication date: Available online 4 June 2016 *Source:*Trends in Cell Biology Author(s): Shuguo Sun, Kenneth D. Irvine The Hippo signaling network integrates diverse upstream signals to control cell fate decisions and regulate organ growth. Recent studies have provided new insights into the cellular organization of Hippo signaling, its relationship to cell–cell junctions, and how the cytoskeleton modulates Hippo signaling. Cell–cell junctions serve as platforms for Hippo signaling by localizing scaffolding proteins that interact with core components of the pathway. Interactions of ... περισσότερα »
Issue Cover (June 2016)
[image: Thumbnail image of graphical abstract] Cover image by Daniel J. Hegeman, Ellie S. Hong, Vivian M. Hernández and C. Savio Chan from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1X69hWp via IFTTT
Tridimensional finite element analysis of teeth movement induced by different headgear forces
Background: This study aimed to simulate the actions of low-pull (LP), high-pull (HP), and combined pull (CP) headgears (HGs) and to analyze tooth movement tendencies through finite element analysis. Methods: Tomographic slices of a human maxilla with complete permanent dentition were processed by reconstruction software, and the triangular surface mesh was converted into non-uniform rational B-spline (NURBS) curves. An HG facial bow was also modulated in 3D. The teeth and bone were considered to have isotropic and linear behavior, whereas the periodontal ligament was considered to...περισσότερα »
Ovarian malignancy unmasked by venous gangrene in a patient on warfarin therapy: a case report
Background: Venous gangrene complicating deep vein thrombosis in the context of anticoagulation use in patients with gynecologic malignancy is rarely reported. We report an unusual presentation of venous gangrene of the lower limbs associated with warfarin therapy in a 53-year-old woman from the Cook Islands with an occult ovarian cancer.Case presentationA 53-year-old woman of Cook Islands origin presented with exertional dyspnea, rapid atrial fibrillation, bilateral lower limb edema, and painful digital ischemia of her hallux. She was on warfarin therapy for atrial fibrillation a...περισσότερα »
The Trans-Pacific Partnership Agreement and health: few gains, some losses, many risks
Background: In early October 2015, 12 nations signed the Trans-Pacific Partnership Agreement (TPPA), promoted as a model '21 st century' trade and investment agreement that other countries would eventually join. There are growing concerns amongst the public health community about the potential health implications of such WTO+ trade and investment agreements, but little existing knowledge on their potential health impacts.Methods and resultsWe conducted a health impact review which allows for a summary estimation of the most significant health impacts of a set of policies, in our c...περισσότερα »
Retrospective cohort analysis of healthcare claims in the United States characterising asthma exacerbations in paediatric patients
Background: Asthma is the most common chronic disease in childhood and places a significant burden on public and private health systems. This retrospective cohort analysis utilised administrative healthcare claims data (US Clinformatics™ Multiplan database; compliant with the US Department of Health & Human Services Health Insurance Portability and Accountability Act) to characterise asthma exacerbations requiring intervention in a US paediatric patient population. Methods: Patients aged > 1–17 years with a recorded asthma diagnosis and receiving treatment were identified in the U... περισσότερα »
High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer’s disease
Background: Increased concentrations of cerebrospinal fluid (CSF) total tau (t-tau) and phosphorylated tau, as well as decreased amyloid-β 42 peptide, are biomarkers of Alzheimer's disease (AD) pathology, but few studies have shown an association with AD progression rate. We hypothesized that high CSF tau, as a marker of ongoing neurodegeneration, would predict a more aggressive course of AD, using time to nursing home placement (NHP) as the main outcome. Methods: Our sample inlcuded 234 patients with mild cognitive impairment (MCI) due to AD (n = 134) or mild to moderate AD (n = 1... περισσότερα »
We need to optimize piperacillin-tazobactam dosing in critically ill patients—but how?
No description available from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1X68BjN via IFTTT
Rapid assessment of knowledge, attitudes, practices, and risk perception related to the prevention and control of Ebola virus disease in three communities of Sierra Leone
Background: The recent outbreak of the Ebola virus disease (EVD) in Sierra Leone has been characterized by the World Health Organization as one of the most challenging EVD outbreaks to date. The first confirmed case in Sierra Leone was a young woman who was admitted to a government hospital in Kenema following a miscarriage on 24 May 2014. On 5 January 2015, intensified training for an EVD response project was initiated at the medical university of Sierra Leone in Jui. To understand the knowledge, attitudes, practices, and perceived risk of EVD among the public, especially after t...περισσότερα »
A prospective multicenter cohort study of frailty in younger critically ill patients
Background: Frailty is a multidimensional syndrome characterized by loss of physiologic and cognitive reserve that heightens vulnerability. Frailty has been well described among elderly patients (i.e., 65 years of age or older), but few studies have evaluated frailty in nonelderly patients with critical illness. We aimed to describe the prevalence, correlates, and outcomes associated with frailty among younger critically ill patients. Methods: We conducted a prospective cohort study of 197 consecutive critically ill patients aged 50–64.9 years admitted to intensive care units (ICU... περισσότερα »
Antiepileptic drug combinations not involving valproate and the risk of fetal malformations
[image: cover.gif?v=1&s=353a143970dce8336631be13] Summary Objective To investigate the relationship between antiepileptic drug (AED) polytherapy in pregnant women and the risk of fetal malformations as prescribing practice changed, with valproate being used less often and at lower doses. Specifically, the risks associated with two of the most common AEDs included in polytherapy over recent years, levetiracetam and topiramate, were examined. Methods An observational cohort study in which malformation rates were analyzed in 1,461 pregnancies exposed to AED monotherapy, and in 484...περισσότερα »
The Reliability of Oral and Pharyngeal Dimensions Captured with Acoustic Pharyngometry
Abstract Acoustic Pharyngometry (APh) is a method for quantifying oropharyngeal tract configuration using sound wave reflection and is commonly used in diagnostics and research of sleep apnea. The standard preset output of APh (minimal cross-sectional area) has been established as reliable. However, by conducting post-processing measures on specific breathing tasks, APh data can also reveal oral length, oral volume, pharyngeal length, and pharyngeal volume. Given that these measures may have utility in dysphagia research, the reliability of these measures is unknown and is the focu...περισσότερα »
Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years
The risk of recurrence of hormone-receptor–positive early breast cancer continues indefinitely. Long-term reduction in the risk of recurrence has been achieved with the antiestrogen agent tamoxifen, aromatase inhibitors, or a combination of the two. These treatments are administered in a variety… from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1stHtPl via IFTTT
Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years
The risk of recurrence of hormone-receptor–positive early breast cancer continues indefinitely. Long-term reduction in the risk of recurrence has been achieved with the antiestrogen agent tamoxifen, aromatase inhibitors, or a combination of the two. These treatments are administered in a variety… from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1stHtPl via IFTTT
Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years
The risk of recurrence of hormone-receptor–positive early breast cancer continues indefinitely. Long-term reduction in the risk of recurrence has been achieved with the antiestrogen agent tamoxifen, aromatase inhibitors, or a combination of the two. These treatments are administered in a variety… from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1stHtPl via IFTTT
Changing Adjuvant Breast-Cancer Therapy with a Signal for Prevention
Five randomized, full-scale studies have reported that 10 years of adjuvant endocrine therapy is beneficial for postmenopausal women with hormone-receptor–positive breast cancer. However, no prior study has involved more than 5 years of aromatase-inhibitor use or assessed a duration of adjuvant… from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1UrZS5b via IFTTT
Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years
The risk of recurrence of hormone-receptor–positive early breast cancer continues indefinitely. Long-term reduction in the risk of recurrence has been achieved with the antiestrogen agent tamoxifen, aromatase inhibitors, or a combination of the two. These treatments are administered in a variety… from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1stHtPl via IFTTT
Changing Adjuvant Breast-Cancer Therapy with a Signal for Prevention
Five randomized, full-scale studies have reported that 10 years of adjuvant endocrine therapy is beneficial for postmenopausal women with hormone-receptor–positive breast cancer. However, no prior study has involved more than 5 years of aromatase-inhibitor use or assessed a duration of adjuvant… from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1UrZS5b via IFTTT
A Plea for Ecological Argument Technologies
Abstract In spite of significant research efforts, argument technologies do not seem poised to scale up as much as most commentators would hope or even predict. In this paper, I discuss what obstacles bar the way to more widespread success of argument technologies and venture some suggestions on how to circumvent such difficulties: doing so will require a significant shift in how this research area is typically understood and practiced. I begin by exploring a much broader yet closely related question: To what extent are people natively good at arguing? This issue has always been ce... περισσότερα »
Χρόνιος πόνος και υποδοχείς της κανναβινόλης
Τα τελευταία χρόνια παρατηρήσεις έχουν φέρει στο φως αποτελέσματα ιδιαίτερης σημασίας για τη θεραπεία του χρόνιου πόνου. [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=P0myg14sWXw:P5ShsHeMr7I:gIN9vFwOq] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1U7SgZG via IFTTT
Φάρμακα για το λουμπάγκο
Επειδή τα περιστατικά του χρόνιου λουμπάγκο, δηλαδή των επώδυνων συνδρόμων στη μέση, αυξάνονται συνεχώς, τα τελευταία χρόνια καινούργια θεραπευτικά σχήματα έχουν αναπτυχθεί. [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=JWOfqjpxHkg:q1553qSAmvw:gIN9vFwOq] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1sZHtXf via IFTTT
Πόνοι στη μέση
Οι πόνοι στη μέση αποτελούν ένα μεγάλο κεφάλαιο της ιατρικής και ένα από τα πιο απλά ταυτόχρονα. [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=gbwkgJk9nRQ:-ZI8sWlbfYU:gIN9vFwOq] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1U7SakO via IFTTT
Πόνοι στη μέση και νευρογλοία
Η νευρογλοία είναι η δομή γύρω από του νευρώνες σε όλο το κεντρικό νευρικό σύστημα, δηλαδή τόσο στον εγκέφαλο όσο και στο νωτιαίο μυελό, η οποία προστατεύει και «τροφοδοτεί» αυτά. [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=cb0aA8MzwRw:F7RulbA0i58:gIN9vFwOq] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1sZH6vz via IFTTT
Οι κανναβινοειδείς υποδοχείς
Οι κανναβινοειδείς υποδοχείς είναι χημικές ουσίες οι οποίες κατανέμονται σε ολόκληρο το σώμα αλλά ιδιαίτερα στο κεντρικό νευρικό σύστημα. [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=fjFjkbz-Ibw:9LxbuQyXMIU:gIN9vFwOq] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1U7RSun via IFTTT
Ο ρόλος της γλυκίνης στο λουμπάγκο
Το λουμπάγκο είναι μία επώδυνη κατάσταση με χρόνιους πόνους στη μέση η οποία έχει μεγάλη «απήχηση» στους ασθενείς όλων των χωρών σε διάφορες καταστάσεις, αλλά κυρίως στον πληθυσμό που εργάζεται χειρωνακτικά. [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=hsGinH7bKY0:v9yVl44Fdqw:gIN9vFwOq] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1sZHE4J via IFTTT
Ο ρόλος της γλουταμάτης στον πόνο
Η γλουταμάτη είναι ένας νευροδιαβιβαστής, ένα πρωτεϊνικό μόριο, το οποίο «κυκλοφορεί» εντός του νευρικού συστήματος με τρόπο έτσι ώστε να διεγείρει διάφορους υποδοχείς, να εκφορτίζουν ταυτόχρονα ευαισθητοποιώντας το κεντρικό νευρικό σύστημα στα διάφορα ερεθίσματα του πόνου. [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=JGLuujOgBG0:j9Ip5sw-4Cc:gIN9vFwOq] from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1U7RQTh via IFTTT
Health-related quality of life after maxillectomy: obturator rehabilitation compared with flap reconstruction
Publication date: Available online 5 June 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): J. Breeze, A. Rennie, A. Morrison, D. Dawson, J. Tipper, K. Rehman, N. Grew, D. Snee, N. Pigadas Health-related quality of life (QoL) reported by patients has the potential to improve care after ablative surgery of the midface, as existing treatment algorithms still generally revolve around outcomes assessed traditionally only by clinicians. Decisions in particular relate to reconstruction with a flap compared with rehabilitation with an obturator, the need for adjuva... περισσότερα »
Cross-cover of oral and maxillofacial surgery out-of-hours: an audit of a new adult treatment clinic
Publication date: Available online 5 June 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): A.K. Abou-Foul, N.P. Shah, J. Mirza, P. Anand We present our experience of launching the adult treatment clinic - a daytime clinic for semiurgent referrals to oral and maxillofacial surgery (OMFS). This has proved to be an effective way in which cross-covering junior doctors could refer patients for a safe and efficient review in a supervised environment. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/28dVaT1 via IFTTT
Outcomes of treatment of fractures of the frontal sinus: review from a tertiary multispecialty craniofacial trauma service
Publication date: Available online 5 June 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Soudeh Chegini, Niamh Gallighan, Niall Mcleod, Rufus Corkill, Stana Bojanic, Stewart Griffiths, Daljit Dhariwal There are no agreed national guidelines for the treatment of fractures of the frontal sinus and the naso-orbitoethmoid complex. The Oxford University Hospitals Craniofacial Trauma unit was set up five years ago as a joint oral and maxillofacial, ENT, and neurosurgical service, and we present our experience to date in the treatment of patients with such fractu... περισσότερα »
Recording Mouse Ultrasonic Vocalizations to Evaluate Social Communication
[image: 53871fig1.jpg] Mouse ultrasonic vocalizations are used as proxies to model the genetic bases of vocal communication deficits in mouse models for neuropsychiatric disorders. The present protocol describes three experimental contexts that reliably elicit ultrasonic vocalizations from pups (throughout development) and adult mice (same-sex interactions, male-estrus female interactions). from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1U7xyck via IFTTT
The concurrent and predictive validity of the Dutch version of the Communicative Development Inventory in children with Down Syndrome for the assessment of expressive vocabulary in verbal and signed modalities
Publication date: September 2016 *Source:*Research in Developmental Disabilities, Volume 56 Author(s): S.R.J.M. Deckers, Y. Van Zaalen, E.J.M. Mens, H. Van Balkom, L. Verhoeven The expressive vocabulary of children with Down Syndrome (DS) is generally measured with parental reports, such as the Communicative Development Inventory (CDI), given that standardized tests for assessing vocabulary levels may be too difficult for most young children with DS. The CDI provides important insight into the parents' perception of their child's vocabulary development. The CDI has proven to be a va... περισσότερα »
The role of biofilm on orthopaedic implants: the “Holy Grail” of post-traumatic infection management?
Abstract The development of post-traumatic infection is potentially a limb threatening condition. The orthopaedic trauma literature lags behind the research performed by our arthroplasty colleagues on the topic of implant-related infections. Surgical site infections in the setting of a recent ORIF are notoriously hard to eradicate due to biofilm formation around the implant. This bacteria-friendly, dynamic, living pluri-organism structure has the ability to morph and adapt to virtually any environment with the aim to maintain the causative organism alive. The challenges are twofol... περισσότερα »
Neural indices of phonemic discrimination and sentence-level speech intelligibility in quiet and noise: A mismatch negativity study
[image: alertIcon.gif] Publication date: Available online 4 June 2016 *Source:*Hearing Research Author(s): Tess K. Koerner, Yang Zhang, Peggy Nelson, Boxiang Wang, Hui Zou Successful speech communication requires the extraction of important acoustic cues from irrelevant background noise. In order to better understand this process, this study examined the effects of background noise on mismatch negativity (MMN) latency, amplitude, and spectral power measures as well as behavioral speech intelligibility tasks. Auditory event-related potentials (AERPs) were obtained from 15 normal-heari... περισσότερα »
Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-β1 Signaling Pathway
This study aim was to explore the effects of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in lupus nephritis and its potential underlying mechanisms. MRL/lpr mice were used for in vivo experiments and human proximal tubular cells (HK2 cells) were used for in vitro experiments. Results showed that MRL/lpr mice treated with vehicle solution or LV-Control shRNA displayed significant proteinuria and severe renal histopathological changes. LV-TWEAK-shRNA treatment reversed these changes and decreased renal expressions of TWEAK, TGF-β1, p-p38 MAPK, p-Smad2, COL-1, and α-...περισσότερα »
Errors as a Means of Reducing Impulsive Food Choice
[image: 53283fig1.jpg] Giving in to temptation of tasty food may result in long-term overweight problems. This protocol describes how to reduce imprudent preference for edible commodities during hypothetical intertemporal choices in women by associating them with errors. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/24rq3OT via IFTTT
Assessing stability in mild and moderate Parkinson’s disease: Can clinical measures provide insight?
Publication date: Available online 5 June 2016 *Source:*Gait & Posture Author(s): Ryan P. Hubble, Peter A. Silburn, Geraldine A. Naughton, Michael H. Cole This cross-sectional study aimed to investigate the relationship between accelerometer-derived measures of movement rhythmicity and clinical measures of mobility, balance confidence and gait difficulty in people with Parkinson's disease (PD). Twenty-nine independently-living PD patients (Hoehn & Yahr stages 1-3) with no history of significant injury or orthopaedic/deep brain stimulation surgery were recruited from a database of p... περισσότερα »
Is age an independent risk factor for medical complications following minimally invasive radical prostatectomy? An evaluation of contemporary American College of Surgeons National Surgical Quality Improvement (ACS-NSQIP) data
Abstract While robotic-assisted laparoscopic radical prostatectomy (RALRP) is an effective treatment for localized prostate cancer, the risk of complications in older patients can be a deterrent to surgery. We evaluated the rate of medical complications following RALRP in a national dataset of safety events, and assessed whether age is an independent risk factor for these complications. Retrospective analysis of patients undergoing RALRP between 2009 and 2012 in the prospectively maintained American College of Surgeons National Surgical Quality Improvement (ACS-NSQIP) database was ... περισσότερα »
Apoptosis-associated protein expression in human salivary gland morphogenesis
Publication date: September 2016 *Source:*Archives of Oral Biology, Volume 69 Author(s): Tathyane H.N. Teshima, Renata C.F. Ianez, Claudia M. Coutinho-Camillo, Abigail S. Tucker, Silvia V. Lourenço ObjectiveSalivary gland (SG) development is based on branching morphogenesis, in which programmed cell death has been proposed to play a role in cell signalling and organ shaping. In the mouse salivary gland apoptosis has been suggested to play a key role in lumen formation, removing the central cells of the epithelial stalks. Here we analyse the expression of several anti- and pro-regula... περισσότερα »
TWiV 392: Zika virus!
Four virologists discuss our current understanding of Zika virus biology, pathogenesis, transmission, and prevention, in this special live episode recorded at the American Society for Microbiology in Washington, DC. Host: from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1Y9zZNm via IFTTT
Pimavanserin: First Global Approval
Abstract Pimavanserin (Nuplazid™) is a selective and potent serotonin 2A (5-HT2A) receptor inverse agonist and antagonist developed by ACADIA Pharmaceuticals that has been approved in the US as a treatment for patients with hallucinations and delusions associated with Parkinson's disease psychosis. Up to 60 % of patients with Parkinson's disease may develop Parkinson's disease psychosis, which is associated with increased morbidity and mortality and has few treatment options. This article summarizes the milestones in the development of pimavanserin leading to this first approval f... περισσότερα »
Analysıs of gene copy number changes ın head and neck cancer.
Analysıs of gene copy number changes ın head and neck cancer.: Analysıs of gene copy number changes ın head and neck cancer. Clin Otolaryngol. 2016 Jun 4; Authors: Baltaci E, Karaman E, Dalay N, Buyru N Abstract OBJECTIVE: Chromosomal alterations and copy number changes are frequent events in tumors, leading to amplification of focal regions containing several oncogenes. Gains and losses of several regions have been reported in head and neck cancer (HNC) but the copy number changes of the individual genes located in these regions have not been analyzed so far. In this study we aim... περισσότερα »
[Preclinical models to establish innovative therapy strategies : Ex‑vivo assessment of head and neck tumor chemo- and immune responses].
[Preclinical models to establish innovative therapy strategies : Ex‑vivo assessment of head and neck tumor chemo- and immune responses].: [Preclinical models to establish innovative therapy strategies : Ex‑vivo assessment of head and neck tumor chemo- and immune responses]. HNO. 2016 Jun 3; Authors: Wichmann G, Dietz A Abstract The pharmacological treatment of head and neck squamous cell carcinoma (HNSCC) is currently experiencing an expansion of the spectrum of targeting therapies. It can be expected that use of immune modulators, e.g., checkpoint-inhibitors, and their combinatio...περισσότερα »
High levels of Phosphatase and Tensin Homolog Expression Predict Favorable Prognosis in Patients with Non-small Cell Lung Cancer.
High levels of Phosphatase and Tensin Homolog Expression Predict Favorable Prognosis in Patients with Non-small Cell Lung Cancer.: High levels of Phosphatase and Tensin Homolog Expression Predict Favorable Prognosis in Patients with Non-small Cell Lung Cancer. Cell Biochem Biophys. 2015 Dec;73(3):631-7 Authors: Li X, Yang Y, Zhang H, Yue W, Zhang T, Lu B, Li J, Liu Z, Wang Q, Gao Y, Hu A, Zhang H, Shi H, Hu F, Li B Abstract The prognostic role of phosphatase and tensin homolog (PTEN) in non-small cell lung cancer (NSCLC) has been controversial. In this study, levels of PTEN expres... περισσότερα »
Characterization of genes coding for galacturonosyltransferase-like (GATL) proteins in rice
Abstract In the present study, seven galacturonosyltransferase-like (GATL) genes ( *OsGATL*s) in rice (*Oryza sativa* L.) were genome-widely identified and the chromosomal locations and the gene structures of which were characterized. Under normal condition, *OsGATL2* and *OsGATL3* are highly expressed in root, while *OsGATL4* is highly expressed in stem and leaf. Many *cis*-elements related to stress response and plant hormone were found in the promoter sequence of each *OsGATL*. The expression patterns of these *OsGATL* genes under treatment with abscisic acid (ABA), drought and lo...περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,June 5th,2016,a
- Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial2016-06-05 12:23:28 AM Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial: Abstract Background Extensive distribution of the different components of renin angiotensin system (RAS) in the brain, along with their roles in promoting anxiety, depression and brain inflammation, opposes RAS as a potential therapeutic ... περισσότερα »
Prognostic value of posttreatment neutrophil–lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy
Prognostic value of posttreatment neutrophil–lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy: An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. AbstractObjective An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. Methods This s... περισσότερα »
Advances in eyelid reconstruction.
Advances in eyelid reconstruction.: Purpose of review: To describe the principles of eyelid reconstruction that must balance aesthetic and functional concerns of one of the most important areas of physical beauty on the human body. Our review seeks to give an overview of how to utilize a variety of techniques along the reconstructive ladder from direct closure to complex grafts and local flaps. Recent findings: We describe novel modifications of existing flaps that have been traditionally used in eyelid reconstruction along with analysis of many time honored techniques and current r... περισσότερα »
New biomaterials versus traditional techniques: advances in cleft palate reconstruction.
New biomaterials versus traditional techniques: advances in cleft palate reconstruction.: Purpose of review: Cleft lip and palate still remains one of the most common congenital anomalies, and consequently surgical correction of these anomalies is still commonplace. Despite numerous existing surgical techniques having good outcomes, it is still recognized that the morbidity of certain surgical procedures and success rates regarding outcomes can be improved. The purpose of this review is to evaluate new literature and techniques compared with the time tested procedures that are commo... περισσότερα »
Update in alar base reduction in rhinoplasty.
Update in alar base reduction in rhinoplasty.: Purpose of review: The purpose of this article is to further explore the techniques available for alar base reduction by a recent review in this topic, focusing in the current advances in the field, in a clear and readable format. Recent findings: Among the numerous techniques available, the management of cases with wide nasal base and alar flaring remains limited to three options: cinching sutures to pull in the alae together; or to use alar base excisions that remove tissue from the alar lobule to decrease flare and from inside the no... περισσότερα »
Simulation in craniomaxillofacial training.
Simulation in craniomaxillofacial training.: Purpose of review: Simulation in healthcare is no longer a novel idea. Simulation continues to rapidly permeate and transform both clinical practice and medical education. Craniomaxillofacial surgery is comprised of multiple surgical disciplines, including neurosurgery, plastic surgery, otolaryngology, ophthalmology, and oral and maxillofacial surgery. All of these specialties are performing surgery in an era of evolving technology, cost containment, reduced resident work hours, and a focus on patient safety. As a result, the purpose of t... περισσότερα »
The Impact of Echocardiographic Screening for Rheumatic Heart Disease on Patient Quality of Life
[image: gr1.sml] To assess the impact of rheumatic heart disease (RHD) on child-reported health-related quality of life (HRQOL) in the context of a Ugandan school-based echocardiographic screening program. Echocardiography-based screening has emerged as a tool for the early detection of RHD, but little is known about its impact on those screened. from Pediatrics via xlomafota13 on Inoreader http://ift.tt/1TPO90Q from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XtBibc via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alex...περισσότερα »
Characterization of genes coding for galacturonosyltransferase-like (GATL) proteins in rice
Abstract In the present study, seven galacturonosyltransferase-like (GATL) genes ( *OsGATL*s) in rice (*Oryza sativa* L.) were genome-widely identified and the chromosomal locations and the gene structures of which were characterized. Under normal condition, *OsGATL2* and *OsGATL3* are highly expressed in root, while *OsGATL4* is highly expressed in stem and leaf. Many *cis*-elements related to stress response and plant hormone were found in the promoter sequence of each *OsGATL*. The expression patterns of these *OsGATL* genes under treatment with abscisic acid (ABA), drought and l...περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,June 5th,2016,a
- Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial2016-06-05 12:23:28 AM Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial: Abstract Background Extensive distribution of the different components of renin angiotensin system (RAS) in the brain, along with their roles in promoting anxiety, depression and brain inflammation, opposes RAS as a potential therapeutic ... περισσότερα »
Prognostic value of posttreatment neutrophil–lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy
Prognostic value of posttreatment neutrophil–lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy: An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. Abstract Objective An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. Methods Thi...περισσότερα »
Advances in eyelid reconstruction.
Advances in eyelid reconstruction.: Purpose of review: To describe the principles of eyelid reconstruction that must balance aesthetic and functional concerns of one of the most important areas of physical beauty on the human body. Our review seeks to give an overview of how to utilize a variety of techniques along the reconstructive ladder from direct closure to complex grafts and local flaps. Recent findings: We describe novel modifications of existing flaps that have been traditionally used in eyelid reconstruction along with analysis of many time honored techniques and current r... περισσότερα »
New biomaterials versus traditional techniques: advances in cleft palate reconstruction.
New biomaterials versus traditional techniques: advances in cleft palate reconstruction.: Purpose of review: Cleft lip and palate still remains one of the most common congenital anomalies, and consequently surgical correction of these anomalies is still commonplace. Despite numerous existing surgical techniques having good outcomes, it is still recognized that the morbidity of certain surgical procedures and success rates regarding outcomes can be improved. The purpose of this review is to evaluate new literature and techniques compared with the time tested procedures that are commo... περισσότερα »
Update in alar base reduction in rhinoplasty.
Update in alar base reduction in rhinoplasty.: Purpose of review: The purpose of this article is to further explore the techniques available for alar base reduction by a recent review in this topic, focusing in the current advances in the field, in a clear and readable format. Recent findings: Among the numerous techniques available, the management of cases with wide nasal base and alar flaring remains limited to three options: cinching sutures to pull in the alae together; or to use alar base excisions that remove tissue from the alar lobule to decrease flare and from inside the no... περισσότερα »
Simulation in craniomaxillofacial training.
Simulation in craniomaxillofacial training.: Purpose of review: Simulation in healthcare is no longer a novel idea. Simulation continues to rapidly permeate and transform both clinical practice and medical education. Craniomaxillofacial surgery is comprised of multiple surgical disciplines, including neurosurgery, plastic surgery, otolaryngology, ophthalmology, and oral and maxillofacial surgery. All of these specialties are performing surgery in an era of evolving technology, cost containment, reduced resident work hours, and a focus on patient safety. As a result, the purpose of t... περισσότερα »
CD166-mediated epidermal growth factor receptor phosphorylation promotes
the growth of oral squamous cell carcinoma via ScienceDirect Search: ESOPHAGEAL CANCER Publication date: August 2016 *Source:*Oral Oncology, Volume 59 Author(s): Guodong Jia, Xu Wang, Ming Yan, Wantao Chen, Ping Zhang CD166 has been considered a relatively specific marker of stem cells and cancer stem cells, and the altered expression of CD166 has also been reported as a prognostic marker of several other types of cancer. However, the molecular functions of CD166 in these cancer cells are largely unknown. In this study, we found that CD166 significantly enhanced epidermal growth fact... περισσότερα »
Hemostatic Properties of Polyphosphate Coacervates
Degradation and via Acta Biomaterialia Publication date: Available online 2 June 2016 *Source:*Acta Biomaterialia Author(s): Arash Momeni, Mark Joseph Filiaggi Sodium polyphosphate is a linear polymer formed from phosphate units linked together by sharing oxygen atoms. Addition of calcium to a solution of sodium polyphosphate results in phase separation and formation of a polyphosphate coacervate best described as a polymeric rich viscoelastic material. Polyphosphate coacervate is an interesting candidate as a biomaterial based on its ability to bind with different cations and to be... περισσότερα »
Lye-induced esophageal stricture
Pseudoepitheliomatous hyperplasia mimicking esophageal squamous cell carcinoma in a patient with Korean J Gastroenterol. 2014 Jun;63(6):366-8 Authors: Han JS, Lee SW, Suh KH, Kim SY, Hyun JJ, Jung SW, Koo JS, Yim HJ Abstract Pseudoepitheliomatous hyperplasia is a benign condition that may be caused by prolonged inflammation, chronic infection, and/or neoplastic conditions of the mucous membranes or skin. Due to its histological resemblance to well-differentiated squamous cell carcinoma, pseudoepitheliomatous hyperplasia may occasionally be misdiagnosed as squamous cell carcinoma.... περισσότερα »
Pentose sugars are the preferred carbon nutrients utilized by H. pylori. The amino acids l-aspartic acid, d-alanine, and l-asparagine serve as both carbon and nitrogen sources in the metabolism of the bacterium.
Elucidation of the Metabolic Network of Helicobacter pylori J99 and Malaysian Clinical Strains by Phenotype Microarray: Abstract Background *Helicobacter pylori* colonizes almost half of the human population worldwide. *H. pylori* strains are genetically diverse, and the specific genotypes are associated with various clinical manifestations including gastric adenocarcinoma, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD). However, our current knowledge of the *H. pylori* metabolism is limited. To understand the metabolic differences among *H. pylori* strains, we investiga...περισσότερα »
Pseudoepitheliomatous hyperplasia mimicking esophageal squamous cell carcinoma
in a patient with lye-induced esophageal stricture.: Korean J Gastroenterol. 2014 Jun;63(6):366-8 Authors: Han JS, Lee SW, Suh KH, Kim SY, Hyun JJ, Jung SW, Koo JS, Yim HJ Abstract Pseudoepitheliomatous hyperplasia is a benign condition that may be caused by prolonged inflammation, chronic infection, and/or neoplastic conditions of the mucous membranes or skin. Due to its histological resemblance to well-differentiated squamous cell carcinoma, pseudoepitheliomatous hyperplasia may occasionally be misdiagnosed as squamous cell carcinoma. The importance of pseudoepitheliomatous hyper...περισσότερα »
Autophagy markers LC3B and p62 in esophageal adenocarcinomas.
Prognostic relevance of Oncotarget. 2016 ; Authors: Adams O, Dislich B, Berezowska S, Schläfli AM, Seiler CA, Kroell D, Tschan MP, Langer R Abstract Esophageal adenocarcinomas (EAC) are aggressive tumors with considerable rates of chemoresistance. Autophagy is a lysosome-dependent degradation process, characterized by the formation of vesicles called autophagosomes, and has been implicated in cancer. Protein light chain 3 B (LC3B) and p62 are associated with autophagosomal membranes and degraded. We aimed to assess the impact of basal autophagy on EAC. In EAC cell lines, an incre... περισσότερα »
Elevating the Head of the Bed for Patients With Gastroesophageal Reflux Disease
[A Systematic Review of the Literature Related to Elevating the Head of the Bed for Patients With Gastroesophageal Reflux Disease: Applications in Patients After Esophageal Cancer Surgery].: Hu Li Za Zhi. 2016 Jun;63(3):83-93 Authors: Huang HC, Fang SY Abstract BACKGROUND: Acid regurgitation typically worsens during nighttime sleep, which influences the quality of life of patients and potentially causes pathological changes. As much as 80% of esophageal cancer patients experience acid regurgitation following esophagectomy and reconstruction surgery. Thus, improving this symptom is...περισσότερα »
Measuring functioning and disability after a disaster: results from the typhoon Haiyan/Yolanda-affected areas of the Philippines.
The most commonly reported data after natural disasters are the number of deceased and displaced and the structural and economic damage, whereas disability data are often lacking. Our study assessed disability among the survivors of the Haiyan/Yolanda typhoon that struck Philippines in 2013 and is aimed to identify which context-level variables are associated with higher disability. We used a cross-sectional design and administered a household questionnaire, an individual sociodemographic questionnaire, and the WHODAS 2.0 to 1982 adults. Logistic regression analysis was carried out ...περισσότερα »
Influence of repetitive peripheral magnetic stimulation on neural plasticity in the motor cortex related to swallowing.
The aim of this study was to evaluate the effect of repetitive peripheral magnetic stimulation at two different frequencies (20 and 30 Hz) on cortical excitability in motor areas related to swallowing in healthy individuals. The study participants were 10 healthy normal volunteers (two women and eight men, age range 25-36 years). Repetitive peripheral magnetic stimulation was applied to the submandibular muscle using a parabolic coil at the site where contraction of the suprahyoid muscles was elicited. Stimulation was continued for 10 min (total 1200 pulses) at 20 Hz on 1 day and at... περισσότερα »
Discovery of new [1,4]dioxino[2,3-f]quinazoline-based inhibitors of EGFR including the T790M/L858R mutant
Publication date: 1 July 2016 *Source:*Bioorganic & Medicinal Chemistry, Volume 24, Issue 13 Author(s): Xuemei Qin, Zhipeng Li, Leifu Yang, Peng Liu, Liming Hu, Chengchu Zeng, Zhiyong Pan A novel series of 2,3-dihydro-[1,4]dioxino[2,3-f]quinazoline derivatives were designed, synthesized and evaluated as reversible and noncovalent epidermal growth factor receptor (EGFR) inhibitors. Most of the compounds exhibited good potency against EGFRwt and some showed moderate to excellent potency against EGFRT790M/L858R mutant. The half-maximal inhibitory concentration (IC50) values of twenty-o...περισσότερα »
Biomedical Engineering and Clinical Medicine, Year 2016, Issue 01 -New Issue Alert.
[image: mail_logo.jpg] New Issue TOC Alert *Dear Valued Customer*, [image: mail_img.jpg] We are pleased to deliver your requested table of contents alert for *Biomedical Engineering and Clinical Medicine*. Year *2016* Issue *01* is now available on CAOD. *In this issue:* Characterization of cellular aggregate formation by rat hippocampal neural stem cell on poly(L-lactic acid) microwell patterns (聚乳酸微小凹图式上大鼠海马神经干细胞聚集体形成行为的研究) ZHONG Dong-huo, ZHANG Li-guang, Lü Yan-ling, FENG Quan-yi, LUO Nan-shu, WU Ze-zhi, Key Laboratory of Biorheological Science and Technology of the State M... περισσότερα »
Pedunculated Epibulbar Osseous Choristoma in a Newborn
Choristomas represent a form of heterotopia, where microscopically normal tissue is found in an abnormal location. Figures 1 and 2 (Figure 2 available at www.jpeds.com) illustrate an episcleral osseous choristoma with a pedunculated appearance as well as a small communicating stalk protruding laterally in the right palpebral fissure. Osseous choristomas are benign and become clinically relevant when they result in incomplete eyelid closure, placing patients at risk for exposure keratopathy, or when they are amblyogenic as a result of partial or complete unilateral occlusion of vis... περισσότερα »
The Impact of Echocardiographic Screening for Rheumatic Heart Disease on Patient Quality of Life
[image: gr1.sml] To assess the impact of rheumatic heart disease (RHD) on child-reported health-related quality of life (HRQOL) in the context of a Ugandan school-based echocardiographic screening program. Echocardiography-based screening has emerged as a tool for the early detection of RHD, but little is known about its impact on those screened. from Pediatrics via xlomafota13 on Inoreader http://ift.tt/1TPO90Q from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XtBibc via IFTTT
Characterization of genes coding for galacturonosyltransferase-like (GATL) proteins in rice
Abstract In the present study, seven galacturonosyltransferase-like (GATL) genes ( *OsGATL*s) in rice (*Oryza sativa* L.) were genome-widely identified and the chromosomal locations and the gene structures of which were characterized. Under normal condition, *OsGATL2* and *OsGATL3* are highly expressed in root, while *OsGATL4* is highly expressed in stem and leaf. Many *cis*-elements related to stress response and plant hormone were found in the promoter sequence of each *OsGATL*. The expression patterns of these *OsGATL* genes under treatment with abscisic acid (ABA), drought and l...περισσότερα »
OtoRhinoLaryngology & Medicine,New Articles,June 5th,2016,a
- Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial2016-06-05 12:23:28 AM Influence of ACE gene on differential response to sertraline versus fluoxetine in patients with major depression: a randomized controlled trial: Abstract Background Extensive distribution of the different components of renin angiotensin system (RAS) in the brain, along with their roles in promoting anxiety, depression and brain inflammation, opposes RAS as a potential therapeutic ... περισσότερα »
Prognostic value of posttreatment neutrophil–lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy
Prognostic value of posttreatment neutrophil–lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy: An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. Abstract Objective An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. Methods Thi...περισσότερα »
Advances in eyelid reconstruction.
Advances in eyelid reconstruction.: Purpose of review: To describe the principles of eyelid reconstruction that must balance aesthetic and functional concerns of one of the most important areas of physical beauty on the human body. Our review seeks to give an overview of how to utilize a variety of techniques along the reconstructive ladder from direct closure to complex grafts and local flaps. Recent findings: We describe novel modifications of existing flaps that have been traditionally used in eyelid reconstruction along with analysis of many time honored techniques and current r... περισσότερα »
New biomaterials versus traditional techniques: advances in cleft palate reconstruction.
New biomaterials versus traditional techniques: advances in cleft palate reconstruction.: Purpose of review: Cleft lip and palate still remains one of the most common congenital anomalies, and consequently surgical correction of these anomalies is still commonplace. Despite numerous existing surgical techniques having good outcomes, it is still recognized that the morbidity of certain surgical procedures and success rates regarding outcomes can be improved. The purpose of this review is to evaluate new literature and techniques compared with the time tested procedures that are commo... περισσότερα »
Update in alar base reduction in rhinoplasty.
Update in alar base reduction in rhinoplasty.: Purpose of review: The purpose of this article is to further explore the techniques available for alar base reduction by a recent review in this topic, focusing in the current advances in the field, in a clear and readable format. Recent findings: Among the numerous techniques available, the management of cases with wide nasal base and alar flaring remains limited to three options: cinching sutures to pull in the alae together; or to use alar base excisions that remove tissue from the alar lobule to decrease flare and from inside the no... περισσότερα »
Simulation in craniomaxillofacial training.
Simulation in craniomaxillofacial training.: Purpose of review: Simulation in healthcare is no longer a novel idea. Simulation continues to rapidly permeate and transform both clinical practice and medical education. Craniomaxillofacial surgery is comprised of multiple surgical disciplines, including neurosurgery, plastic surgery, otolaryngology, ophthalmology, and oral and maxillofacial surgery. All of these specialties are performing surgery in an era of evolving technology, cost containment, reduced resident work hours, and a focus on patient safety. As a result, the purpose of t... περισσότερα »
CD166-mediated epidermal growth factor receptor phosphorylation promotes
the growth of oral squamous cell carcinoma via ScienceDirect Search: ESOPHAGEAL CANCER Publication date: August 2016 *Source:*Oral Oncology, Volume 59 Author(s): Guodong Jia, Xu Wang, Ming Yan, Wantao Chen, Ping Zhang CD166 has been considered a relatively specific marker of stem cells and cancer stem cells, and the altered expression of CD166 has also been reported as a prognostic marker of several other types of cancer. However, the molecular functions of CD166 in these cancer cells are largely unknown. In this study, we found that CD166 significantly enhanced epidermal growth fact... περισσότερα »
Hemostatic Properties of Polyphosphate Coacervates
Degradation and via Acta Biomaterialia Publication date: Available online 2 June 2016 *Source:*Acta Biomaterialia Author(s): Arash Momeni, Mark Joseph Filiaggi Sodium polyphosphate is a linear polymer formed from phosphate units linked together by sharing oxygen atoms. Addition of calcium to a solution of sodium polyphosphate results in phase separation and formation of a polyphosphate coacervate best described as a polymeric rich viscoelastic material. Polyphosphate coacervate is an interesting candidate as a biomaterial based on its ability to bind with different cations and to be... περισσότερα »
Pentose sugars are the preferred carbon nutrients utilized by H. pylori. The amino acids l-aspartic acid, d-alanine, and l-asparagine serve as both carbon and nitrogen sources in the metabolism of the bacterium.
Elucidation of the Metabolic Network of Helicobacter pylori J99 and Malaysian Clinical Strains by Phenotype Microarray: Abstract Background *Helicobacter pylori* colonizes almost half of the human population worldwide. *H. pylori* strains are genetically diverse, and the specific genotypes are associated with various clinical manifestations including gastric adenocarcinoma, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD). However, our current knowledge of the *H. pylori* metabolism is limited. To understand the metabolic differences among *H. pylori* strains, we investiga...περισσότερα »
Lye-induced esophageal stricture
Pseudoepitheliomatous hyperplasia mimicking esophageal squamous cell carcinoma in a patient with Korean J Gastroenterol. 2014 Jun;63(6):366-8 Authors: Han JS, Lee SW, Suh KH, Kim SY, Hyun JJ, Jung SW, Koo JS, Yim HJ Abstract Pseudoepitheliomatous hyperplasia is a benign condition that may be caused by prolonged inflammation, chronic infection, and/or neoplastic conditions of the mucous membranes or skin. Due to its histological resemblance to well-differentiated squamous cell carcinoma, pseudoepitheliomatous hyperplasia may occasionally be misdiagnosed as squamous cell carcinoma.... περισσότερα »
Pseudoepitheliomatous hyperplasia mimicking esophageal squamous cell carcinoma
in a patient with lye-induced esophageal stricture.: Korean J Gastroenterol. 2014 Jun;63(6):366-8 Authors: Han JS, Lee SW, Suh KH, Kim SY, Hyun JJ, Jung SW, Koo JS, Yim HJ Abstract Pseudoepitheliomatous hyperplasia is a benign condition that may be caused by prolonged inflammation, chronic infection, and/or neoplastic conditions of the mucous membranes or skin. Due to its histological resemblance to well-differentiated squamous cell carcinoma, pseudoepitheliomatous hyperplasia may occasionally be misdiagnosed as squamous cell carcinoma. The importance of pseudoepitheliomatous hyper...περισσότερα »
Autophagy markers LC3B and p62 in esophageal adenocarcinomas.
Prognostic relevance of Oncotarget. 2016 ; Authors: Adams O, Dislich B, Berezowska S, Schläfli AM, Seiler CA, Kroell D, Tschan MP, Langer R Abstract Esophageal adenocarcinomas (EAC) are aggressive tumors with considerable rates of chemoresistance. Autophagy is a lysosome-dependent degradation process, characterized by the formation of vesicles called autophagosomes, and has been implicated in cancer. Protein light chain 3 B (LC3B) and p62 are associated with autophagosomal membranes and degraded. We aimed to assess the impact of basal autophagy on EAC. In EAC cell lines, an incre... περισσότερα »
Liaoning Pharmacy and Clinical Remedies, Year 2015, Issue 11 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Liaoning Pharmacy and Clinical Remedies*. Year *2015* Issue *11* is now available on CAOD. *In this issue: * Effect of sevoflurane preconditioning on the concentration of plasma I-FABP and Dlactate and bacterial translocation in hemorrhagic shock pigs (七氟烷预处理对失血性休克猪血浆肠脂肪酸结合蛋白、D-乳酸浓度和细菌移位的影响) WANG Li-jing, SUN Ying-jie, DIAO Yu-gang, ZHANG Tie-zheng, JIN Qiang, Department of Anesthesiology, The General Hospital of Shenyang Military Region ...... page:1271-1275 Ef... περισσότερα »
Journal of Clinical Emergency Call, Year 2016, Issue 03 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Clinical Emergency Call*. Year *2016* Issue *03* is now available on CAOD. *In this issue: * Acute cerebral hemorrhage:emergency treatment basing on expert consensus (急性脑出血:从专家共识到急诊救治) SUN Shujie, WANG Zhizuo ...... page:165-168 di 12 jie zhong guo zhong xi yi jie he xue hui zai hai yi xue fen hui xue shu nian hui zuo 2016 zai hai yi xue yu ji wei zhong zheng gao duan lun tan hui yi tong zhi (第12届中国中西医结合学会灾害医学分会学术年会暨2016灾害医学与急危重症高端论坛会议通知) ...... page... περισσότερα »
Chinese Journal of Cancer Prevention and Treatment, Year 2015, Issue 16 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Cancer Prevention and Treatment*. Year *2015* Issue *16* is now available on CAOD. *In this issue: * zhong hua zhong liu fang zhi za zhi she tai li ji you ce yi shu zuo pin zheng ji qi shi (《中华肿瘤防治杂志》社台历及邮册艺术作品征集启事) ...... page:1253 zhong hua zhong liu fang zhi za zhi qing nian bian wei zhao mu qi shi (《中华肿瘤防治杂志》青年编委招募启事) YU Jinming, ZUO Wenshu ...... page:1256 Clinical application value of magnifying endoscopy combined with narrow band imag... περισσότερα »
Chinese Journal of Pharmaceutical Analysis, Year 2015, Issue 08 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Pharmaceutical Analysis*. Year *2015* Issue *08* is now available on CAOD. *In this issue: * Applications of oligonucleotide aptamers in small molecule analysis (核酸适配子在小分子检测中的应用) ZHANG Yan-fen, XIE Yao, WANG Nan-nan, ZHAO Li-jian, LIU Li-peng, LIU Zhong-Cheng, Science and Technology Office, Hebei University, College of Pharmaceutical Sciences, Hebei University ...... page:1317-1322 yao wu fen xi za zhi bian ji bu sheng ming (《药物分析杂志》编辑部声明) ..... περισσότερα »
Shanghai Journal of Medical Laboratory Sciences, Year 2016, Issue 02 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Shanghai Journal of Medical Laboratory Sciences*. Year *2016* Issue *02* is now available on CAOD. *In this issue: * Consensus on the analysis quality goal of clinical laboratories(Ⅱ) (临床实验室分析质量目标的共识(下)) FENG Renfeng, Shanghai Center for Clinical Laboratory ...... page:83-86 Expression and its significance of DNMT3A in adult patients with acute myeloid leukemia (成人急性髓系白血病中DNMT3A的表达及其意义) WANG Xiaorui, YANG Yining, QIN Youwen, Department of Hematology, Shanghai Ge... περισσότερα »
West China Journal of Pharmaceutical Sciences, Year 2015, Issue 06 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *West China Journal of Pharmaceutical Sciences*. Year *2015* Issue *06* is now available on CAOD. *In this issue: * Synthesis of benzofuran derivatives and their effect on promoting bone formation (苯骈呋喃类衍生物的合成及促骨形成作用) LI Rui-peng, GUO Li, ZHENG Hu, QI Qing-rong, West China School of Pharmacy, Sichuan University ...... page:631-634 Synthesis of gitogenin 3β-O-chacotrioside as H5N1 entry inhibitor (H5N1进入抑制剂马铃薯三糖吉托皂苷的合成) LI Yi-bin, LIN Ru-heng, ZHENG Yu-shan, FAN J... περισσότερα »
Journal of Oral Science Research, Year 2016, Issue 03 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Oral Science Research*. Year *2016* Issue *03* is now available on CAOD. *In this issue: * Impact of Fusobacterium Nucleatum and Porphyromonas Gingivalis Modulation on the Cell Cycle and Cytokines Production of KB Cells (具核梭杆菌调控牙龈卟啉单胞菌感染对口腔鳞状细胞癌KB细胞周期和细胞因子分泌的研究) WANG Qing-xuan, LIU Jun-chao, PAN Ya-ping, School of Stomatology, China Medical University ...... page:211-215 S1P/S1PR1 Regulates Chemotaxis of Osteoclast Precursors under Compressive Stress ... περισσότερα »
Journal of Clinical Otorhinolaryngology Head and Neck Surgery, Year 2016, Issue 07 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Clinical Otorhinolaryngology Head and Neck Surgery*. Year *2016* Issue *07* is now available on CAOD. *In this issue: * Correlation studies of specific immune indexes in vitro testing and noninvasive fungalsinusitis (体外特异性免疫指标检测与非侵袭性真菌性鼻窦炎发生的相关性研究) GEYing, KONG Hui, Dalian Medical University, Department of Otorhinolaryngology, the Second Affiliated Hospital of Dalian Medical University ...... page:513-515 che gao sheng ming (撤稿声明) ...... page:515 Th... περισσότερα »
Clinical Focus, Year 2016, Issue 03 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Clinical Focus*. Year *2016* Issue *03* is now available on CAOD. *In this issue: * Correct diagnosis and standardized treatment of Graves' hyperthyroidism (Graves'甲状腺功能亢进症的正确诊断与规范化治疗) Feng Jue, Department of Nuclear Medicine, the Second Hospital of Hebei Medical University ...... page:233-236 Progress in diagnosis and treatment of subclinical hyperthyroidism (亚临床甲状腺功能亢进症的诊治) Zhang Lihui, Yuan Lingling, Department of Endocrinology, the Second Hospital of Hebei M... περισσότερα »
Journal of Clinical Neurosurgery, Year 2016, Issue 02 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Clinical Neurosurgery*. Year *2016* Issue *02* is now available on CAOD. *In this issue: * lin chuang shen jing wai ke za zhi zheng ding zheng gao qi shi (《临床神经外科杂志》征订、征稿启事) ...... page:79 nei jing lu di wai ke shou shu zhong de lu di zhong jian (内镜颅底外科手术中的颅底重建) MA Chiyuan, ZHANG Yazhuo ...... page:81-82 Anatomic reposition of sellar floor and its early results after endoscopic endonasal transsphenoidal pituitary surgery (神经内镜下经鼻蝶入路垂体腺瘤手术的鞍底解剖复位技术及其早... περισσότερα »
Journal of Otolaryngology and Ophthalmology of Shandong University, Year 2016, Issue 02 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Otolaryngology and Ophthalmology of Shandong University*. Year *2016* Issue *02* is now available on CAOD. *In this issue: * Operation skill and standard diagnosis and treatment are the basics of improving the curative effect of thyroid carcinoma (强化手术技能和规范诊疗是提高甲状腺癌疗效的根本) FANG Jugao, Department of Otolaryngology & Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology-Head & Neck Surgery Ministry of... περισσότερα »
Biomedical Engineering and Clinical Medicine, Year 2016, Issue 01 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Biomedical Engineering and Clinical Medicine*. Year *2016* Issue *01* is now available on CAOD. *In this issue: * Characterization of cellular aggregate formation by rat hippocampal neural stem cell on poly(L-lactic acid) microwell patterns (聚乳酸微小凹图式上大鼠海马神经干细胞聚集体形成行为的研究) ZHONG Dong-huo, ZHANG Li-guang, Lü Yan-ling, FENG Quan-yi, LUO Nan-shu, WU Ze-zhi, Key Laboratory of Biorheological Science and Technology of the State Ministry of Education, College of Bioengine... περισσότερα »
Journal of Practical Diagnosis and Therapy, Year 2016, Issue 04 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Practical Diagnosis and Therapy*. Year *2016* Issue *04* is now available on CAOD. *In this issue: * Research progress of miR-133a in tumor occurrence and development (miR-133a与肿瘤发生发展研究进展) WANG Yu-zhou, LI Jin-mei, YANG Zhi-xiong, Centre for Oncology, the Affiliated Hospital of Guangdong Medical College ...... page:313-315 Research progress of methylation of circulating cell free DNA (循环游离DNA甲基化研究进展) YANG Jie, TANG Dong-ling, Department of Clinical La... περισσότερα »
Journal of Practical Oncology, Year 2016, Issue 01 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Practical Oncology*. Year *2016* Issue *01* is now available on CAOD. *In this issue: * ji wang kai lai , ge gu ding xin (继往开来,革故鼎新) ZHANG Suzhan ...... page:1 jie zhi chang ai yan jiu 30 nian hui gu he xian zhuang (结直肠癌研究30年回顾和现状) ZHENG Shu, ZHANG Suzhan, HUANG Yanqin ...... page:2-5 e xing zhong liu mian yi zhi liao de xian zhuang ji zhan wang (恶性肿瘤免疫治疗的现状及展望) XIAO Peng, CAO Xuetao, WANG Qingqing ...... page:5-9 chang dao jun qun yu e xing zhong li... περισσότερα »
Chinese Journal of Cellular and Molecular Immunology, Year 2015, Issue 10 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Cellular and Molecular Immunology*. Year *2015* Issue *10* is now available on CAOD. *In this issue: * Effects of simulated weightlessness on biological activity of human NK cells induced by IL-2 (模拟失重对IL-2诱导的人NK细胞生物活性的影响) LIU Wenli, ZHU Xia, ZHAO Li, YANG Xiling, CAO Fei, HUANG Yong, MU Peihong, Hospital of North West Agriculture and Forestry University, Department of Medical Psychology, Fourth Military Medical University, College of Veterinary... περισσότερα »
Recent Advances in Ophthalmology, Year 2016, Issue 04 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Recent Advances in Ophthalmology*. Year *2016* Issue *04* is now available on CAOD. *In this issue: * Neuroprotective effects of ultrasonic microbubbles and mouse nerve growth factor on rabbit hypertension optic nerve damage (超声微泡造影剂联合鼠神经生长因子对高眼压兔视神经损害的保护作用) SHEN Xiao-Li, FAN Ning, ZHAO Jun, LI Qiang, HUANG Li-Na, Affiliated Shenzhen Eye Hospital of Jinan University, Shenzhen Key Laboratory of Ophthalmology, Shenzhen People's Hospital ...... page:301-305 Biologi... περισσότερα »
Chinese Journal of Conservative Dentistry, Year 2016, Issue 04 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Conservative Dentistry*. Year *2016* Issue *04* is now available on CAOD. *In this issue: * The effects of cyclic hydrostatic pressure on the mechano-growth factor expression in periodontal ligamengt stem cells (周期性动态压力对人牙周膜干细胞中力生长因子表达的影响) ZOU De-hui, ZHAO Ying, ZHAO Yin-hua, CHEN Yong-jin, ZHANG Min, State Key Laboratory of Military Stomatology, Department of General Dentistry & Emergency, School of Stomatology, The Fourth Military Medical Univ... περισσότερα »
Journal of Medical Biomechanics, Year 2016, Issue 02 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Medical Biomechanics*. Year *2016* Issue *02* is now available on CAOD. *In this issue: * Development and validation of finite element model for 6-year-old pediatric neck (6岁儿童全颈有限元模型的构建及验证) L Wen-le, RUAN Shi-jie, LI Hai-yan, CUI Shi-hai, HE Li-juan, WANG Chun-xiang, Center for Injury Biomechanics and Vehicle Safety Engineering, Tianjin University of Science and Technology, Department of Radiology, Tianjin Children's Hospital ...... page:95-101 yi y... περισσότερα »
Chinese Journal of Otorhinolaryngology-skull Base Surgery, Year 2015, Issue 04 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Otorhinolaryngology-skull Base Surgery*. Year *2015* Issue *04* is now available on CAOD. *In this issue: * zhong guo er bi yan hou lu di wai ke za zhi gao yue (《中国耳鼻咽喉颅底外科杂志》稿约) ...... page:266 yin ni xing jing lin ba jie zhuan yi tou jing lin ai yan jiu zhong yi ge zhi de guan zhu de wen ti (隐匿性颈淋巴结转移——头颈鳞癌研究中一个值得关注的问题) ZHANG Xin, HUANG Donghai ...... page:267-270 zhong guo er bi yan hou lu di wai ke za zhi chuang kan 20 zhou nian xue shu l... περισσότερα »
Chinese Journal of Laser Medicine & Surgery, Year 2015, Issue 04 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Laser Medicine & Surgery*. Year *2015* Issue *04* is now available on CAOD. *In this issue: * Clinical Efficacy of Combined Application of CO2 Laser and Compound Betamethasone in Treating Arytenoid Cartilage Granuloma (支撑喉显微镜下CO2 激光联合复方倍他米松治疗杓状软骨肉芽肿的疗效分析) KANG Jing, QUAN Hua-tao, LIU Chao, WU Ping, LIU Yong, TANG Yao-yun, ZHANG Shuai, Department of Otolaryngology & Head and Neck Surgery, Xiangya Hospital, Central South University, Key Laboratory... περισσότερα »
Chinese Journal of Clinical Pharmacology and Therapeutics, Year 2016, Issue 03 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of Clinical Pharmacology and Therapeutics*. Year *2016* Issue *03* is now available on CAOD. *In this issue: * zhong guo lin chuang yao li xue yu zhi liao xue za zhi jian jie (《中国临床药理学与治疗学》杂志简介) ...... page:236 Effects of dorsal/ventral hippocampus lesion in neuropathic pain rats (背/腹侧海马毁损对神经病理性疼痛大鼠的影响) ZHANG Fang-fang, MA Qian, WEI Ming-yang, HU Hong-yi, XIE Xiao-yan, ZHANG Juan, Department of Anesthesiology, the First Affiliated Hospital of Zh... περισσότερα »
The Chinese Journal of Dermatovenereology, Year 2016, Issue 03 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *The Chinese Journal of Dermatovenereology*. Year *2016* Issue *03* is now available on CAOD. *In this issue: * Screening for Differentially Expressed Proteins of Protein Tyrosine Kinase in rh PTH(1-34)-induced Keratinocytes (rhPTH(1-34)诱导角质形成细胞蛋白酪氨酸激酶差异表达蛋白的筛选) BU Xiao-lin, BI Xin-ling, GU Jun, WANG Wu-qing, SHI Yu-ling, XU Xiao-guang, WANG GUO-jiang, Department of Dermatology, Shanghai Gongli Hospital, Secondary Military Medical University, Department of Dermatol... περισσότερα »
The Chinese Journal of Modern Applied Pharmacy, Year 2016, Issue 04 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *The Chinese Journal of Modern Applied Pharmacy*. Year *2016* Issue *04* is now available on CAOD. *In this issue: * Effects of Bevacizumab on the Expression of VEGF-A of Serum and Subcutaneous Tumor in Nude Mice with Lewis Cancer (贝伐单抗对Lewis肺癌裸鼠血清及移植瘤中血管内皮生长因子A表达的影响) CHEN Fang, ZHANG Liting, WANG Lu, TONG Weiquan, XIA Tingting, XU Zhibo, ZHENG Lidan, LIU Xianzhong, Lung Function Laboratory, The First Affliated Hospital of Zhejiang Chinese Medical University, The ... περισσότερα »
Chinese Journal of New Drugs, Year 2016, Issue 08 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Chinese Journal of New Drugs*. Year *2016* Issue *08* is now available on CAOD. *In this issue: * 2016 zhong guo guo ji yao wu xin xi da hui zuo di ba jie dia zhong guo nian hui lian xi zhu xi huan ying nin (2016中国国际药物信息大会暨第八届DIA中国年会联席主席欢迎您) ...... page:839 Analysis of the current situation of the Chinese traditional medicine patent application in China and the corresponding suggestions (我国中药专利申请现状分析及建议) QIN Yu, DONG Li, School of Business Administration, Shenyan... περισσότερα »
Journal of Chinese Pharmaceutical Sciences, Year 2016, Issue 04 -New Issue Alert.
New Issue TOC Alert *Dear Valued Customer*, We are pleased to deliver your requested table of contents alert for *Journal of Chinese Pharmaceutical Sciences*. Year *2016* Issue *04* is now available on CAOD. *In this issue: * Cancers chemoprevention by dietary phytochemicals and traditional Chinese medicines: epigenetics and cellular signaling pathways Ah-Ng Tony Kong, Siwang Yu, Department of Pharmaceutics, Earnest Mario School of Pharmacy, Rutgers, The State University of New Jersey, School of Pharmaceutical Sciences, Peking University Health Science Center ...... page:23... περισσότερα »
Elevating the Head of the Bed for Patients With Gastroesophageal Reflux Disease
[A Systematic Review of the Literature Related to Elevating the Head of the Bed for Patients With Gastroesophageal Reflux Disease: Applications in Patients After Esophageal Cancer Surgery].: Hu Li Za Zhi. 2016 Jun;63(3):83-93 Authors: Huang HC, Fang SY Abstract BACKGROUND: Acid regurgitation typically worsens during nighttime sleep, which influences the quality of life of patients and potentially causes pathological changes. As much as 80% of esophageal cancer patients experience acid regurgitation following esophagectomy and reconstruction surgery. Thus, improving this symptom is...περισσότερα »
Measuring functioning and disability after a disaster: results from the typhoon Haiyan/Yolanda-affected areas of the Philippines.
The most commonly reported data after natural disasters are the number of deceased and displaced and the structural and economic damage, whereas disability data are often lacking. Our study assessed disability among the survivors of the Haiyan/Yolanda typhoon that struck Philippines in 2013 and is aimed to identify which context-level variables are associated with higher disability. We used a cross-sectional design and administered a household questionnaire, an individual sociodemographic questionnaire, and the WHODAS 2.0 to 1982 adults. Logistic regression analysis was carried out ...περισσότερα »
Influence of repetitive peripheral magnetic stimulation on neural plasticity in the motor cortex related to swallowing.
The aim of this study was to evaluate the effect of repetitive peripheral magnetic stimulation at two different frequencies (20 and 30 Hz) on cortical excitability in motor areas related to swallowing in healthy individuals. The study participants were 10 healthy normal volunteers (two women and eight men, age range 25-36 years). Repetitive peripheral magnetic stimulation was applied to the submandibular muscle using a parabolic coil at the site where contraction of the suprahyoid muscles was elicited. Stimulation was continued for 10 min (total 1200 pulses) at 20 Hz on 1 day and at... περισσότερα »
Discovery of new [1,4]dioxino[2,3-f]quinazoline-based inhibitors of EGFR including the T790M/L858R mutant
Publication date: 1 July 2016 *Source:*Bioorganic & Medicinal Chemistry, Volume 24, Issue 13 Author(s): Xuemei Qin, Zhipeng Li, Leifu Yang, Peng Liu, Liming Hu, Chengchu Zeng, Zhiyong Pan A novel series of 2,3-dihydro-[1,4]dioxino[2,3-f]quinazoline derivatives were designed, synthesized and evaluated as reversible and noncovalent epidermal growth factor receptor (EGFR) inhibitors. Most of the compounds exhibited good potency against EGFRwt and some showed moderate to excellent potency against EGFRT790M/L858R mutant. The half-maximal inhibitory concentration (IC50) values of twenty-o...περισσότερα »
Prognostic value of posttreatment neutrophil–lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy
Prognostic value of posttreatment neutrophil–lymphocyte ratio in head and neck squamous cell carcinoma treated by chemoradiotherapy: An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. Abstract Objective An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. Methods Thi...περισσότερα »
Advances in eyelid reconstruction.
Advances in eyelid reconstruction.: Purpose of review: To describe the principles of eyelid reconstruction that must balance aesthetic and functional concerns of one of the most important areas of physical beauty on the human body. Our review seeks to give an overview of how to utilize a variety of techniques along the reconstructive ladder from direct closure to complex grafts and local flaps. Recent findings: We describe novel modifications of existing flaps that have been traditionally used in eyelid reconstruction along with analysis of many time honored techniques and current r... περισσότερα »
New biomaterials versus traditional techniques: advances in cleft palate reconstruction.
New biomaterials versus traditional techniques: advances in cleft palate reconstruction.: Purpose of review: Cleft lip and palate still remains one of the most common congenital anomalies, and consequently surgical correction of these anomalies is still commonplace. Despite numerous existing surgical techniques having good outcomes, it is still recognized that the morbidity of certain surgical procedures and success rates regarding outcomes can be improved. The purpose of this review is to evaluate new literature and techniques compared with the time tested procedures that are commo... περισσότερα »
Update in alar base reduction in rhinoplasty.
Update in alar base reduction in rhinoplasty.: Purpose of review: The purpose of this article is to further explore the techniques available for alar base reduction by a recent review in this topic, focusing in the current advances in the field, in a clear and readable format. Recent findings: Among the numerous techniques available, the management of cases with wide nasal base and alar flaring remains limited to three options: cinching sutures to pull in the alae together; or to use alar base excisions that remove tissue from the alar lobule to decrease flare and from inside the no... περισσότερα »
Simulation in craniomaxillofacial training.
Simulation in craniomaxillofacial training.: Purpose of review: Simulation in healthcare is no longer a novel idea. Simulation continues to rapidly permeate and transform both clinical practice and medical education. Craniomaxillofacial surgery is comprised of multiple surgical disciplines, including neurosurgery, plastic surgery, otolaryngology, ophthalmology, and oral and maxillofacial surgery. All of these specialties are performing surgery in an era of evolving technology, cost containment, reduced resident work hours, and a focus on patient safety. As a result, the purpose of t... περισσότερα »
CD166-mediated epidermal growth factor receptor phosphorylation promotes
the growth of oral squamous cell carcinoma via ScienceDirect Search: ESOPHAGEAL CANCER Publication date: August 2016 *Source:*Oral Oncology, Volume 59 Author(s): Guodong Jia, Xu Wang, Ming Yan, Wantao Chen, Ping Zhang CD166 has been considered a relatively specific marker of stem cells and cancer stem cells, and the altered expression of CD166 has also been reported as a prognostic marker of several other types of cancer. However, the molecular functions of CD166 in these cancer cells are largely unknown. In this study, we found that CD166 significantly enhanced epidermal growth fact... περισσότερα »
Hemostatic Properties of Polyphosphate Coacervates
Degradation and via Acta Biomaterialia Publication date: Available online 2 June 2016 *Source:*Acta Biomaterialia Author(s): Arash Momeni, Mark Joseph Filiaggi Sodium polyphosphate is a linear polymer formed from phosphate units linked together by sharing oxygen atoms. Addition of calcium to a solution of sodium polyphosphate results in phase separation and formation of a polyphosphate coacervate best described as a polymeric rich viscoelastic material. Polyphosphate coacervate is an interesting candidate as a biomaterial based on its ability to bind with different cations and to be... περισσότερα »
Pentose sugars are the preferred carbon nutrients utilized by H. pylori. The amino acids l-aspartic acid, d-alanine, and l-asparagine serve as both carbon and nitrogen sources in the metabolism of the bacterium.
Elucidation of the Metabolic Network of Helicobacter pylori J99 and Malaysian Clinical Strains by Phenotype Microarray: Abstract Background *Helicobacter pylori* colonizes almost half of the human population worldwide. *H. pylori* strains are genetically diverse, and the specific genotypes are associated with various clinical manifestations including gastric adenocarcinoma, peptic ulcer disease (PUD), and nonulcer dyspepsia (NUD). However, our current knowledge of the *H. pylori* metabolism is limited. To understand the metabolic differences among *H. pylori* strains, we investiga...περισσότερα »
Lye-induced esophageal stricture
Pseudoepitheliomatous hyperplasia mimicking esophageal squamous cell carcinoma in a patient with Korean J Gastroenterol. 2014 Jun;63(6):366-8 Authors: Han JS, Lee SW, Suh KH, Kim SY, Hyun JJ, Jung SW, Koo JS, Yim HJ Abstract Pseudoepitheliomatous hyperplasia is a benign condition that may be caused by prolonged inflammation, chronic infection, and/or neoplastic conditions of the mucous membranes or skin. Due to its histological resemblance to well-differentiated squamous cell carcinoma, pseudoepitheliomatous hyperplasia may occasionally be misdiagnosed as squamous cell carcinoma.... περισσότερα »
Pseudoepitheliomatous hyperplasia mimicking esophageal squamous cell carcinoma
in a patient with lye-induced esophageal stricture.: Korean J Gastroenterol. 2014 Jun;63(6):366-8 Authors: Han JS, Lee SW, Suh KH, Kim SY, Hyun JJ, Jung SW, Koo JS, Yim HJ Abstract Pseudoepitheliomatous hyperplasia is a benign condition that may be caused by prolonged inflammation, chronic infection, and/or neoplastic conditions of the mucous membranes or skin. Due to its histological resemblance to well-differentiated squamous cell carcinoma, pseudoepitheliomatous hyperplasia may occasionally be misdiagnosed as squamous cell carcinoma. The importance of pseudoepitheliomatous hyper...περισσότερα »
Autophagy markers LC3B and p62 in esophageal adenocarcinomas.
Prognostic relevance of Oncotarget. 2016 ; Authors: Adams O, Dislich B, Berezowska S, Schläfli AM, Seiler CA, Kroell D, Tschan MP, Langer R Abstract Esophageal adenocarcinomas (EAC) are aggressive tumors with considerable rates of chemoresistance. Autophagy is a lysosome-dependent degradation process, characterized by the formation of vesicles called autophagosomes, and has been implicated in cancer. Protein light chain 3 B (LC3B) and p62 are associated with autophagosomal membranes and degraded. We aimed to assess the impact of basal autophagy on EAC. In EAC cell lines, an incre... περισσότερα »
Elevating the Head of the Bed for Patients With Gastroesophageal Reflux Disease
[A Systematic Review of the Literature Related to Elevating the Head of the Bed for Patients With Gastroesophageal Reflux Disease: Applications in Patients After Esophageal Cancer Surgery].: Hu Li Za Zhi. 2016 Jun;63(3):83-93 Authors: Huang HC, Fang SY Abstract BACKGROUND: Acid regurgitation typically worsens during nighttime sleep, which influences the quality of life of patients and potentially causes pathological changes. As much as 80% of esophageal cancer patients experience acid regurgitation following esophagectomy and reconstruction surgery. Thus, improving this symptom is...περισσότερα »
A Protocol for Management of the Hairs Problem in Oral Cavity Reconstruction by Submental Flap
Abstract Background Submental flap is a useful aid in maxillofacial reconstruction. For intraoral usage the hairs in male patients will create some problems. Materials and Methods In a retrospective study, patients in whom submental flap had been used for reconstruction of orofacial region between 2007 and 2013, in the Mashhad University, Ghaem Hospital, were included. The ways in which the problem of hairs was solved in male patients were evaluated. Results There were 42 patients in whom submental flap was used for orofacial reconstruction. Sixty percent were males. Three ways h...περισσότερα »
Congenital Hypertonia of the Temporalis Leading to Trismus Since Birth
Abstract Congenital trismus is quite rare especially when its etiology is not the usual. In our case report an 8 year old female patient with no history of forcep delivery, no history of trauma or infection and a non syndromic presents with trismus since birth. After thorough examination we could conclude that the cause is due to hypertonia of the temporalis muscle and its etiology is discussed. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1X3Ggut via IFTTT
The utility of p16 immunostaining in fine needle aspiration in p16-positive head and neck squamous cell carcinoma
Publication date: August 2016 *Source:*Human Pathology, Volume 54 Author(s): Bin Xu, Ronald Ghossein, Jason Lane, Oscar Lin, Nora Katabi Many patients with human papillomavirus (HPV)–related head and neck squamous cell carcinoma present initially with cervical nodal metastasis. Fine needle aspiration (FNA) of the nodal disease might be the only diagnostic material available for p16 immunohistochemistry (IHC) and HPV testing. The current study aims to evaluate p16 IHC in FNA and establish guidelines for its interpretation. The percentage and intensity of p16 IHC staining were examine...περισσότερα »
Real-World Effectiveness and Safety of a Live-Attenuated Herpes Zoster Vaccine: A Comprehensive Review
Abstract Abstract Herpes zoster (HZ) is a common, painful and debilitating disease caused by the reactivation of latent varicella-zoster virus in ganglia. This clinical event occurs more frequently in the elderly and those who are immunocompromised. The most common complication of HZ is post-herpetic neuralgia (PHN) which is responsible for the highest HZ-related burden of illness and is challenging to treat. Due to the important clinical and economic impact of HZ and PHN, and the suboptimal treatments that are currently available, HZ vaccination is an important approach to reduce ...περισσότερα »
Multiple efficacy studies of an adenovirus-vectored foot-and-mouth disease virus serotype A24 subunit vaccine in cattle using homologous challenge
[image: 1-s2.0-S0264410X16X00278-cov150h.gif] Publication date: 8 June 2016 *Source:*Vaccine, Volume 34, Issue 27 Author(s): Christopher Schutta, José Barrera, Melia Pisano, Laszlo Zsak, Marvin J. Grubman, Gregory A. Mayr, Mauro P. Moraes, Barbara J. Kamicker, David A. Brake, Damodar Ettyreddy, Douglas E. Brough, Bryan T. Butman, John G. Neilan The safety and efficacy of an experimental, replication-deficient, human adenovirus-vectored foot-and-mouth disease virus (FMDV) serotype A24 Cruzeiro capsid-based subunit vaccine (AdtA24) was examined in eight independent cattle studies. Adt... περισσότερα »
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