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an umbrella review of systematic reviews and meta-analyses: AbstractPurposeMethotrexate chemotherapy is associated with various toxicities which can result in the interruption or discontinuation of treatment and a subsequently raised risk of relapse. This umbrella systematic review was conducted to synthesize...
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Mechanism-based modeling of the clinical effects of AbstractPurposeTo describe the natural growth of vestibular schwannoma in patients with neurofibromatosis type 2 and to predict tumor volume evolution in patients treated with bevacizumab and everolimus.MethodsClinical data, including longitudinal tumor...
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Phase 1 study of AbstractPurposeTAS-102 is a novel oral agent combining the antineoplastic thymidine-based nucleoside analogue, trifluridine, and the thymidine phosphorylase inhibitor, tipiracil (molar ratio 1:0.5). TAS-102 has shown good activity in refractory metastatic colorectal cancer with acceptable...
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A clinical drug–drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib: AbstractPurposeThe Hedgehog pathway inhibitor vismodegib exhibits pH-dependent solubility,...
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Phase II trial of AbstractPurposeAlthough locally advanced head and neck squamous cell carcinoma (HNSCC) can be effectively treated using chemoradiotherapy (CRT) with docetaxel (DTX), and cisplatin (CDDP) plus 5-fluorouracil (TPF-CRT), severe adverse events (especially neutropenia) can limit treatment...
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Mitochondria: Inadvertent targets in chemotherapy-induced skeletal muscle toxicity and wasting?: AbstractChemotherapy has been associated with increased mitochondrial reactive oxygen species production, mitochondrial dysfunction and skeletal muscle atrophy leading to severe patient clinical complications...
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Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors: AbstractPurposeIndenoisoquinolines are non-camptothecin topoisomerase I (TopI) inhibitors that overcome the limitations of camptothecins: chemical instability...
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Phase I safety and pharmacokinetic dose-escalation study of pilaralisib polymorph E, a phosphoinositide 3-kinase inhibitor in tablet formulation, in patients with solid tumors or lymphoma: AbstractPurposePilaralisib (SAR245408), a pan-class I PI3K inhibitor, has been investigated in Phase I/II trials...
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Understanding the role of tariquidar, a potent Pgp inhibitor, in combination trials with cytotoxic drugs: What is missing?Everolimus pharmacokinetics and its exposure–toxicity relationship in patients with thyroid cancerAbstractBackgroundEverolimus is a mTOR inhibitor used for the treatment of different...
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Understanding the role of tariquidar, a potent Pgp inhibitor, in combination trials with cytotoxic drugs: What is missing?Everolimus pharmacokinetics and its exposure–toxicity relationship in patients with thyroid cancerAbstractBackgroundEverolimus is a mTOR inhibitor used for the treatment of different...
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Everolimus pharmacokinetics and its exposure-toxicity relationship in patients with thyroid cancer.:Cancer Chemother Pharmacol. 2016 May ;Authors: de Wit D, Schneider TC, Moes DJ, Roozen CF, den Hartigh J, Gelderblom H, Guchelaar HJ, van der Hoeven JJ, Links TP, Kapiteijn E, van Erp NPAbstract ...
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MxA mediates SUMO-induced resistance to Vesicular Stomatitis VirusJ Virol. 2016 May ;Authors: Maarifi G, Hannoun Z, Geoffroy MC, El Asmi F, Zarrouk K, Nisole S, Blondel D, Chelbi-Alix MKAbstract Multiple cellular pathways are regulated by small ubiquitin like modifier (SUMO) modification, including...
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In Press, Corrected Proof, Sara Sena Esteves, Carla Cardoso, Ana Silva, José Abrunhosa, Cecília Almeida e SousaClose abstract Purchase PDF - $35.95AbstractHereditary hemorrhagic telangiectasia (HHT), also known by the eponym Osler-Weber-Rendu syndrome, is an autosomal dominant disorder characterised...
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Original Research ArticleIn Press, Corrected Proof, Available online 13 April 2016Abdelrahman E. Ezzat, Hanna M. EL-Shenawy, Marwa M. El-Begermy, Mustafa I. Eid, Ayman Y. AbbasClose abstract Purchase PDF - $35.95AbstractIntroduction and objectiveThe most common postoperative complications of velopharyngeal...
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Aneurisma de vena yugular internaIn Press, Corrected Proof, Available online 13 May 2016Mariel S. Riedemann Wistuba, Amer A. Zanabili Al-Sibbai, Lino Camblor SantervásFirst page PDF Purchase PDF - $35.95
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: causa infrecuente de ulceración nasalvia Acta Otorrinolaringológica EspañolaPublication date: Available online 13 May 2016Source:Acta Otorrinolaringológica EspañolaAuthor(s): Carlos Morales-Raya, Esther García-González, Lidia Maroñas-Jiménez
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Ausencia de translocaciones cromosómicas y de expresión proteica de ALK en los adenocarcinomas nasosinusalesvia Acta Otorrinolaringológica EspañolaPublication date: Available online 13 May 2016Source:Acta Otorrinolaringológica EspañolaAuthor(s): Esteban Pacheco, José Luis Llorente, Alejandro López-Hernández,...
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Timpanometría de alta frecuencia (1.000 Hz) en lactantes y su comparación con otoemisiones acústicas, otomicroscopia y timpanometría de 226 HzOriginal Research ArticleIn Press, Corrected Proof, Available online 13 May 2016Eduardo A. Mena-Domínguez, José I. Benito-Orejas, Beatriz Ramírez-Cano, Darío Morais-Pérez,...
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: A retrospective study on prognostic factors from a single institute databaseYiMing Chen1,, Qingcheng Shen1,, Sandhya Gokavarapu, Chengzhong Lin, Yahiya, Wei Cao,Shubhra Chauhan, Zheqi Liu, Tong Ji, Zhen Tian1Equal first authors.Oral Oncology, Volume 58Received: February 15, 2016; Received in revised...
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: An extremely rare tumorvia Acta Otorrinolaringológica EspañolaPublication date: Available online 13 May 2016Source:Acta Otorrinolaringológica EspañolaAuthor(s): Konstantinos Valsamidis, Iokasti Koutsampasopoulou, Konstantinos Titelis
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: Review of the literatureCamelia Nami Saber1, Christian Grønhøj Larsen1,, Tina Dalianis, Christian von Buchwald1Shared first authorship.Oral Oncology, Volume 58Received: January 13, 2016; Received in revised form: April 5, 2016; Accepted: April 12, 2016; Published Online:May 07, 2016DOI: http://dx.doi.org/10.1016/j.oraloncology.2016.04.004 | Highlights•First...
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Cervical nodal level V can safely be omitted in the treatment of locally advanced oropharyngeal squamous cell carcinoma with definitive IMRT: Intensity modulated radiotherapy (IMRT) has emerged as the favored radiation modality for the definitive and post operative treatment of locally advanced head...
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Can preoperative thyroglobulin antibody levels be used as a marker for well differentiated thyroid cancer?: AbstractBackgroundIt has been reported that thyroglobulin antibody are more frequently elevated in patients with thyroid cancercompared to general population. This study aims at evaluating whether...
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Impact of post-chemoradiotherapy superselective/selective neck dissection on patient reported quality of lifevia ScienceDirect Publication: Oral OncologyPublication date: July 2016Source:Oral Oncology, Volume 58Author(s): Kyle Wang, Robert J. Amdur, William M. Mendenhall, Rebecca Green, Shannon Aumer,...
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Can preoperative thyroglobulin antibody levels be used as a marker for well differentiated thyroid cancer?: AbstractBackgroundIt has been reported that thyroglobulin antibody are more frequently elevated in patients with thyroid cancercompared to general population. This study aims at evaluating whether...
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Non-stationary Bayesian estimation of parameters from a body cover model of the vocal folds: The evolution of reduced-order vocal fold models into clinically useful tools for subject-specific diagnosis and treatment hinges upon successfully and accurately representing an individual patient in the modeling...
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A simulation framework for auditory discrimination experiments: Revealing the importance of across-frequency processing in speech perception: A framework for simulating auditory discrimination experiments, based on an approach from Schädler, Warzybok, Hochmuth, and Kollmeier [(2015). Int. J. Audiol....
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On Older Listeners' Ability to Perceive Dynamic Pitch: PurposeNatural speech comes with variation in pitch, which serves as an important cue for speech recognition. The present study investigated older listeners' dynamic pitch perception with a focus on interindividual variability. In particular, we...
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Mal de debarquementFrom Wikipedia, the free encyclopediaMal de debarquement (or Mal de débarquement) syndrome (MdDS, or common name disembarkment syndrome) is a rare neurological condition usually occurring after a cruise, aircraft flight, or other sustained motion event. The phrase "mal de débarquement"...
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Double-Blind Sham-Controlled Crossover Trial of Repetitive Transcranial Magnetic Stimulation for Mal de Debarquement Syndrome.by Cha, Yoon-Hee; Deblieck, Choi; Wu, Allan D. via Otology & Neurotology - Published Ahead-of-PrintAbstractObjective: To determine whether the chronic rocking dizziness that...
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A simulation model of microsphere distribution for selective internal radiation therapy agrees with observationsvia International Journal of Radiation Oncology*Biology*PhysicsPublication date: Available online 13 May 2016Source:International Journal of Radiation Oncology*Biology*PhysicsAuthor(s): Jonas...
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Wireless and acoustic hearing with bone-anchored hearing devices: 10.1080/14992027.2016.1177209<br/>Arjan J. BosmanObjective: The efficacy of wireless connectivity in bone-anchored hearing was studied by comparing the wireless and acoustic performance of the Ponto Plus sound processor from Oticon...
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for Older Adults.J Am Board Fam Med. 2016 May-Jun;29(3):394-403Authors: Contrera KJ, Wallhagen MI, Mamo SK, Oh ES, Lin FRAbstract Hearing deficits are highly prevalent among older adults and are associated with declines in cognitive, physical, and mental health. However, hearing loss in the...
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SLC26A4 and GJB3 genesMol Med Rep. 2016 May 13;Authors: Li Y, Zhu BAbstract Mutations in the SLC26A4 gene have been shown to cause a type of deafness referred to as large vestibular aquduct syndrome (LVAS), whereas mutations in the GJB3 gene have been associated with nonsyndromic deafness. However,...
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Radiation enhances immune response to anti-tumor antibodies: Interest in combining radiotherapy and immune checkpoint therapy is growing rapidly. In this study, we explored a novel combination of this type to augment anti-tumor immune responses in preclinical murine models of melanoma, neuroblastoma,...
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Abstract A33: A role of This study addressed a potential role of SET/I2PP2A protein on angiogenesis and immune response in head and neck squamous cell carcinoma (HNSCC). A HNSCC cell line with stable SET knockdown (HN12shSET/HN12shControl), previously established in our laboratory, was used to perform...
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Abstract B02 Background: Neuronal progenitors in the brain are born in sites known as germinal zones (GZ) where they undergo proliferation and differentiation before migrating to their final positions at a distant site. Developmental cues that control this transition are tightly regulated to ensure proper...
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Dynamic Baseline Variations and Drug Sensitivity: Cell-to-cell variations contribute to drug resistance with consequent therapy failure in cancer. Experimental techniques have been developed to monitor tumor heterogeneity, but estimates of cell-to-cell variation typically fail to account for the expected...
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CD4+ T-cell Help in Therapeutic Cancer Vaccination: While showing promise, vaccination strategies to treat cancer require further optimization. Likely barriers to efficacy involve cancer-associated immunosuppression and peripheral tolerance, which limit the generation of effective vaccine-specific cytotoxic...
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Olfactomedin 4 expression and functions in innate immunity, inflammation, and cancer: AbstractOlfactomedin 4 (OLFM4) is an olfactomedin domain-containing glycoprotein. Multiple signaling pathways and factors, including NF-κB, Wnt, Notch, PU.1, retinoic acids, estrogen receptor, and miR-486, regulate...
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Efficacy of the neurokinin-1 receptor antagonist rolapitant in preventing nausea and vomiting in patients receiving carboplatin-based chemotherapy: BACKGROUNDRolapitant, a novel neurokinin-1 receptor antagonist, provided effective protection against chemotherapy-induced nausea and vomiting (CINV) in...
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Addition of Rice Bran Arabinoxylan to Curcumin Therapy May Be of Benefit to Patients With Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia): A Preliminary Clinical Study: Hypothesis. Prior...
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Induced by Cyclophosphamide Administration in Experimental Animals: Background. Curculigo orchioides Gaertn is an ancient medicinal plant (Family: Amaryllidaceae), well known for its immunomodulatory and rejuvenating effects. Cyclophosphamide (CPA) is an alkylating agent widely used for treating a variety...
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Phase 2 Study of A prospective phase 2 study was conducted to evaluate the clinical utility of acupuncture-like transcutaneous nerve stimulation (ALTENS) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). Eligible cancer patients had a < 2 ECOG performance score, received neurotoxic...
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Effects of High Doses of Vitamin C on Cancer Patients in Singapore: Nine Cases: Introduction. Intravenous high-dose vitamin C therapy is widely used in naturopathic and integrative oncology; however, a study reviewing its effects has never been performed in Singapore. This article serves to document...
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Phase II randomized trial of We previously reported the safety of the novel, non-platinum combination of cetuximab, pemetrexed and radiation therapy in head and neck cancer. Given extensive EGFR-VEGF pathway crosstalk, we conducted a randomized study evaluating this combination with or without bevacizumab....
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Somatic RET mutation in a patient with pigmented adrenal pheochromocytoma: SummaryPheochromocytomas (PCC) and paraganglioma (PGL) are rare neuroendocrine tumors arising from chromaffin cells of the neural crest. Mutations in the RET-proto-oncogene are associated with sporadic pheochromocytoma, familial...
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MDSCs' significance in ipilimumab treated melanoma patients: PURPORSE: High levels of circulating myeloid derived suppressor cells (MDSCs) in various cancer types, including melanoma, were shown to correlate with poor survival. We investigated whether frequencies of circulating CD33+CD11b+HLA-DR- MDSCs...
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in military veterans: retrospective cohort study of 57,000 veterans and 173,000 matched non-veterans: AbstractBackgroundServing military personnel are more likely to smoke, and to smoke more heavily, than civilians. The aim of our study was to examine whether veterans have an increased risk of a range...
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An allograft mouse model for the study of hearing loss secondary to vestibular schwannoma growth: AbstractVestibular schwannoma is a benign neoplasm arising from the Schwann cell sheath of the auditory-vestibular nerve. It most commonly affects both sides in the genetic condition Neurofibromatosis type...
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are Related to Elevated Serum Thyroglobulin Levels After Radioactive Iodine Therapy in Patients with Papillary Thyroid Carcinoma: AbstractPurposeSerum thyroglobulin (Tg) level is frequently elevated shortly after radioactive iodine (RAI) ablation therapy. The authors studied the relationship between...
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Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients: AbstractBackgroundIt was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration...
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Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients: AbstractBackgroundIt was reported that metastases might occur via transfer of biologically active blood circulating molecules from the primary tumor to distant organs rather than only migration...
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An Analysis to Evaluate Possible Bias Due to Prevalent Users and Healthy User Aspects: Statins are said to protect against a wide range of diseases. We studied to what extent potential bias influences the results of studies on beneficial side effects of statins. We selected 8,188 atrial fibrillation...
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Association of Hemoglobin Concentration With Total and Cause-Specific Mortality in a Cohort of Postmenopausal Women: Anemia and low and high levels of hemoglobin have been associated with increased mortality and morbidity. However, most studies have measured hemoglobin at only 1 time point, and few studies...
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and Risks of Coronary Heart Disease, Cardiovascular Disease, and Death: Results From the Multi-Ethnic Study of Atherosclerosis: Prior studies observing associations between low levels of high-density lipoprotein (HDL) cholesterol and cardiovascular disease (CVD) have often been conducted among persons...
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With and Without an Infection in a National Cohort of Medicare Beneficiaries: Research has implicated low 25-hydroxyvitamin D (25(OH)D) level as a risk factor for infection; however, results have not been consistent. To further determine the nature of this relationship, we conducted a cohort study using...
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Background Certain chronic diseases such as migraine result in episodic, debilitating attacks for which neither cause nor timing is well understood. Historically, possible triggers were identified through analysis of aggregated data from populations of patients. However, triggers common in populations...
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It has been reported that thyroglobulin antibody are more frequently elevated in patients with thyroid cancercompared to general population. This study aims at evaluating whether preoperative thyroglobulin ant... from #ORL via xlomafota13 on Inoreader http://ift.tt/27nEGHf via IFTTT
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Publication date: July 2016Source:Oral Oncology, Volume 58 Author(s): Kyle Wang, Robert J. Amdur, William M. Mendenhall, Rebecca Green, Shannon Aumer, Trevor G. Hackman, Adam M. Zanation, Jose P. Zevallos, Samip N. Patel, Mark C. Weissler, Bhishamjit S. Chera ObjectivesTo describe patient-reported...
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Abstract Background It has been reported that thyroglobulin antibody are more frequently elevated in patients with thyroid cancercompared to general population. This study aims at evaluating whether preoperative thyroglobulin antibody (TgAb) levels increase the likelihood that a thyroid nodule is malignant....
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Abstract The German Society of Otorhinolaryngology, Head and Neck Surgery recently has released the abbreviated version of its scientific guideline "ENT-specific therapy of obstructive sleep apnoea (OSA) in adults", which has been updated in 2015 and can be found online at the Association of the Scientific...
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Intensity modulated radiotherapy (IMRT) has emerged as the favored radiation modality for the definitive and post operative treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) [1,2]. Numerous prospective studies have demonstrated comparable tumor control rates with lower incidence...
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