Cigarette use, comorbidities, and prognosis in a prospective head and neck squamous cell carcinoma population
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
[image: cover.gif?v=1&s=f302950f6434daecbd65a56c] ABSTRACT Background To better understand the associations between a history of tobacco use and survival outcomes, cigarette use was prospectively surveyed in 687 previously untreated patients with cancer of the oral cavity (*n* = 271), oropharynx (*n* = 257), larynx (*n* = 135), or hypopharynx (*n* = 24). Methods Kaplan–Meier and Cox models explored the associations of tobacco use intensity (packs/day), duration (years of use), and timing before diagnosis with overall survival (OS), disease-specific survival (DSS), and recurrenc... περισσότερα »
Conjunctival Allergen Provocation Test in daily practice. Guidelines from the Task Force Report of the EAACI Ocular Allergy Interest Group
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Abstract Conjunctival allergen provocation test (CAPT) reproduces the events occurring by instilling an allergen on the ocular surface. This paper is the compilation of a task force focussed on practical aspects of this technique based on the analysis of 131 papers. Main mechanisms involved are reviewed. Indications are diagnosing the allergen(s) triggering symptoms in IgE-mediated ocular allergy in seasonal, acute or perennial forms of allergic conjunctivitis, especially when the relevance of the allergen is not obvious or in polysensitized patients. Contraindications are limited ... περισσότερα »
Is It Worthwhile Treating Occluded Cold Stored Venous Allografts by Thrombolysis?
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Publication date: Available online 18 July 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): P. Balaz, P. Wohlfahrt, S. Rokosny, S. Maly, M. Bjorck ObjectivesThrombolysis has been reported to be suboptimal in occluded vein grafts and cryopreserved allografts, and there are no data on the efficacy of thrombolysis in occluded cold stored venous allografts. The aim was to evaluate early outcomes, secondary patency and limb salvage rates of thrombolysed cold stored venous allograft bypasses and to compare the outcomes with thrombolysis of autologous bypasses.... περισσότερα »
Three-dimensional Ultrasound in the Management of Abdominal Aortic Aneurysms: A Topical Review
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Publication date: Available online 18 July 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): C. Lowe, Q. Ghulam, K. Bredahl, S. Rogers, J. Ghosh, H. Sillesen, C.N. McCollum, J. Eiberg Three-dimensional (3D) ultrasound is an evolving modality that may have numerous applications in the management of abdominal aortic aneurysms. Many vascular specialists will not be familiar with the different ways in which 3D vascular ultrasound data can be acquired nor how potential applications are being explored by researchers. Most of the current literature consists of ... περισσότερα »
Epidemiology of onychomycosis in Crete, Greece: a 12-year study
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Summary Onychomycosis is a chronic fungal nail infection caused by dermatophytes, yeasts or non-dermatophyte moulds (NDMs). It occurs worldwide and accounts for about 50% of all nail disorders. The incidence of the disease and the prevalence of pathogens involved vary in different geographical areas and change with time. This study was undertaken to determine the epidemiology of onychomycosis in Crete, Greece during a 12-year period. Mycologic nail investigation (direct microscopy and cultures) was performed in samples taken from 3417 patients with clinical suspicion of onychomycos... περισσότερα »
Molecular identification and phylogenetical analysis of dermatophyte fungi from Latin America
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Summary Dermatophytes constitute a complex group of fungi, comprised of by the genera *Trichophyton*, *Epidermophyton* and *Microsporum*. They have the ability to degrade keratin and cause human and animal infections. Molecular techniques have made their identification faster and more accurate, and allowed important advances in phylogenetic studies. We aim to identify molecularly and to determine the phylogenetic relationships in dermatophyte fungi from Brazil and other Latin American countries, using DNA sequencing of the nuclear ribosome regions ITS1-5.8S-ITS2 and D1/D2. DNA of 4... περισσότερα »
Japanese Journal of Clinical Oncology
Alexandros G. SfakianakisστοMedical Articles from India and Jaypee Journals by Sfakianakis G. AlexandrosΠριν από 4 δευτερόλεπτα
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Alexandros G. SfakianakisστοMedical Articles from India and Jaypee Journals by Sfakianakis G. AlexandrosΠριν από 4 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* pubmed: jaypee[all fields] *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be view... περισσότερα »
Ayurvedic medicine in Mauritius: Profile of Ayurvedic outlet, use, sale, distribution, regulation and importation.
Alexandros G. SfakianakisστοMedical Articles from India and Jaypee Journals by Sfakianakis G. AlexandrosΠριν από 4 δευτερόλεπτα
*Ayurvedic medicine in Mauritius: Profile of Ayurvedic outlet, use, sale, distribution, regulation and importation.* J Ethnopharmacol. 2016 Jul 13; Authors: Elaheebocus N, Mahomoodally F Abstract ETHNOPHARMACOLOGICAL RELEVANCE: Ayurvedic medicine (AM) is a legalized alternative traditional medical system in the multicultural tropical island of Mauritius. A panoply of Ayurvedic specialised shops/centers involved in the provision of Ayurvedic services hereafter termed as'outlets' operates in different regions of the island and is extensively exploited by a significant number of Mau... περισσότερα »
Traditional herbal prescription LASAP-C inhibits melanin synthesis in B16F10 melanoma cells and zebrafish.
Alexandros G. SfakianakisστοMedical Articles from India and Jaypee Journals by Sfakianakis G. AlexandrosΠριν από 4 δευτερόλεπτα
*Traditional herbal prescription LASAP-C inhibits melanin synthesis in B16F10 melanoma cells and zebrafish.* BMC Complement Altern Med. 2016;16(1):223 Authors: Kim MK, Bang CY, Kim MY, Lee JH, Ro H, Choi MS, Kim DI, Jang YP, Choung SY Abstract BACKGROUND: In this study, the anti-melanogenesis efficacy of clinically used herbal prescription LASAP-C, which consists of four herbal medicines-Rehmanniae Radix Crudus, Lycii Fructus, Scutellariae Radix, and Angelicae Dahuricae Radix, was investigated. METHODS: The chemical profile of LASAP-C was established by conducting ultra-performan... περισσότερα »
Cigarette use, comorbidities, and prognosis in a prospective head and neck squamous cell carcinoma population
[image: cover.gif?v=1&s=f302950f6434daecbd65a56c] ABSTRACT Background To better understand the associations between a history of tobacco use and survival outcomes, cigarette use was prospectively surveyed in 687 previously untreated patients with cancer of the oral cavity (*n* = 271), oropharynx (*n* = 257), larynx (*n* = 135), or hypopharynx (*n* = 24). Methods Kaplan–Meier and Cox models explored the associations of tobacco use intensity (packs/day), duration (years of use), and timing before diagnosis with overall survival (OS), disease-specific survival (DSS), and recurrenc... περισσότερα »
The International Journal of Medical Robotics and Computer Assisted Surgery
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* The International Journal of Medical Robotics and Computer Assisted Surgery *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatic... περισσότερα »
Brain and Development
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 8 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ScienceDirect Publication: Brain and Development *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your com... περισσότερα »
Early Post-Hepatoportoenterostomy Predictors of Native Liver Survival in Biliary Atresia.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 21 δευτερόλεπτα
Objectives: Most infants with biliary atresia (BA) require liver transplantation (LT) following hepatoportoenterostomy (HPE), including those who initially clear jaundice. The aim of this study was to identify clinical and routine laboratory factors in BA infants post-HPE that predict native liver survival at 2 years. Methods: A retrospective cohort study was conducted with 217 BA patients undergoing HPE in Sydney, Australia and Toronto, Canada between January 1986-July 2009. Univariate and multivariate logistic regression using backwards-stepwise elimination identified variables at... περισσότερα »
Maternal Infections, Antibiotics and Paracetamol in Pregnancy and Offspring Celiac Disease: A Cohort Study.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 21 δευτερόλεπτα
Objectives: Infections in pregnancy are common, may affect fetal development and have been linked to offspring autoimmunity. We aimed to determine whether maternal infections, the use of antibiotics and paracetamol in pregnancy are associated with the risk of offspring celiac disease (CD). Methods: The nationwide Norwegian Mother and Child Cohort Study includes 84,274 children born in 2000-2009 with prospectively collected questionnaire data on maternal infections and medication use in pregnancy. CD was identified through questionnaires and the Norwegian Patient Register. Logistic r... περισσότερα »
Tacrolimus Exerts Only a Transient Effectiveness in Refractory Pediatric Crohn Disease: a Case Series.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 21 δευτερόλεπτα
Objectives: Tacrolimus is an immunosuppressive agent that has been proposed in the treatment of severe ulcerative colitis. This study examined the effectiveness and safety of tacrolimus in treating refractory Crohn Disease (CD) colitis in children. Methods: All children treated by oral tacrolimus for CD colitis at a tertiary pediatric center were included in the study. All patients were refractory to steroids and infliximab. Clinical response (decreased PCDAI >15 and PCDAI from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29WMutw via IFTTT
Use of Reticulocyte Hemoglobin Content in the Assessment of Iron Deficiency in Children with Inflammatory Bowel Disease.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 21 δευτερόλεπτα
Background: Iron deficiency and anemia affect up to 50-75% of inflammatory bowel disease (IBD) patients. Iron deficiency in IBD may be difficult to diagnose because of the effect of inflammation on iron status biomarkers. Thus, there is a need for better methods to accurately determine iron status in IBD. Objective: To investigate the association of inflammation with hemoglobin content of reticulocytes (CHr) and the utility of CHr in comparison to standard iron biomarkers. Design/Methods: We conducted a cross-sectional study of children with IBD. Iron biomarkers [CHr, ferritin, solu... περισσότερα »
Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN).
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 21 δευτερόλεπτα
Cholestatic jaundice in infancy affects approximately 1 in every 2500 term infants and is infrequently recognized by primary providers in the setting of physiologic jaundice. Cholestatic jaundice is always pathologic and indicates hepatobiliary dysfunction. Early detection by the primary care physician and timely referrals to the pediatric gastroenterologist/hepatologist are important contributors to optimal treatment and prognosis. The most common causes of cholestatic jaundice in the first months of life are biliary atresia (BA, 25-40%) followed by an expanding list of monogenic d... περισσότερα »
A New Old Treatment for Vitamin E Deficiency in Cholestasis.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 21 δευτερόλεπτα
No abstract available from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/29QDGld via IFTTT
Oral Tocofersolan Corrects or Prevents Vitamin E Deficiency in Children with Chronic Cholestasis.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 21 δευτερόλεπτα
Background/Aims: d-alpha-tocopheryl polyethylene glycol 1000 succinate (Tocofersolan, Vedrop(R)), has been developed in Europe to provide an orally bioavailable source of vitamin E in children with cholestasis. The aim was to analyze the safety/efficacy of Vedrop(R) in a large group of children with chronic cholestasis. Methods: 274 Children receiving Vedrop(R) for vitamin E deficiency or for its prophylaxis were included from 7 European centers. Median age at treatment onset was 2 months and median follow-up was 11 months. Vedrop(R) was prescribed at a daily dose of 0.34 ml/kg (25 ... περισσότερα »
Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 24 δευτερόλεπτα
Objectives: To extend our understanding of how interindividual variability mediates the efficacy of cancer treatment. Materials and methods: The kinetics of dacarbazine (DTIC) N-demethylation by the most frequent polymorphic variants of CYP1A1 (T461N, I462V) and CYP1A2 (F186L, D348N, I386F, R431W, R456H) were characterized, along with kinetic parameters for the O-deethylation of the prototypic CYP1A substrate 7-ethoxyresorufin, using recombinant protein expression and high-performance liquid chromatographic techniques. Results: A reduction of ~30% in the catalytic efficiencies (meas... περισσότερα »
Conjunctival Allergen Provocation Test in daily practice. Guidelines from the Task Force Report of the EAACI Ocular Allergy Interest Group
Abstract Conjunctival allergen provocation test (CAPT) reproduces the events occurring by instilling an allergen on the ocular surface. This paper is the compilation of a task force focussed on practical aspects of this technique based on the analysis of 131 papers. Main mechanisms involved are reviewed. Indications are diagnosing the allergen(s) triggering symptoms in IgE-mediated ocular allergy in seasonal, acute or perennial forms of allergic conjunctivitis, especially when the relevance of the allergen is not obvious or in polysensitized patients. Contraindications are limited ... περισσότερα »
European Archives of Oto-Rhino-Laryngology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
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European Archives of Oto-Rhino-Laryngology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
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Current Opinion in Otolaryngology & Head and Neck Surgery – Current Issue
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
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Clinical Otolaryngology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
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Case Reports in Otolaryngology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
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Pipeline Embolization Device for Recurrent Cerebral Aneurysms after Microsurgical Clipping
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Publication date: September 2016Source:World Neurosurgery, Volume 93 Author(s): Nimer Adeeb, Christoph J. Griessenauer, Justin Moore, Christopher J. Stapleton, Aman B. Patel, Raghav Gupta, Apar S. Patel, Ajith J. Thomas, Christopher S. OgilvyBackgroundMicrosurgical clipping is regarded as the most durable treatment for cerebral aneurysms. Aneurysm recurrence after clipping is uncommon and is associated with an increased […]
Association Between Comorbidities, Nutritional Status, and Anticlotting Drugs and Neurologic Outcomes in Geriatric Patients with Traumatic Brain Injury
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Publication date: September 2016Source:World Neurosurgery, Volume 93 Author(s): Tomoya Okazaki, Toru Hifumi, Kenya Kawakita, Ryuta Nakashima, Atsushi Matsumoto, Hajime Shishido, Daiske Ogawa, Masanobu Okauchi, Atsushi Shindo, Masahiko Kawanishi, Takashi Tamiya, Yasuhiro KurodaBackgroundSeveral studies using trauma data banks and registers showed that age, Glasgow Coma Scale (GCS), Injury Severity Score, and intraventricular hemorrhage were independent factors […]
Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Publication date: September 2016Source:World Neurosurgery, Volume 93 Author(s): Dorothee Cäcilia Spille, Katharina Heß, Cristina Sauerland, Nader Sanai, Walter Stummer, Werner Paulus, Benjamin BrokinkelObjectiveIn meningioma, correlation of brain invasion with prognosis and clinical variables remains controversial.MethodsCorrelation of brain invasion with clinical and histopathologic variables was investigated in 467 patients with primary intracranial meningioma.ResultsDiffuse (n = 3; 10%), […]
Acta Otorrinolaringológica Española
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
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The Journal of the Acoustical Society of America
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed!Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! The Journal of the Acoustical […]
Is It Worthwhile Treating Occluded Cold Stored Venous Allografts by Thrombolysis?
Publication date: Available online 18 July 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): P. Balaz, P. Wohlfahrt, S. Rokosny, S. Maly, M. Bjorck ObjectivesThrombolysis has been reported to be suboptimal in occluded vein grafts and cryopreserved allografts, and there are no data on the efficacy of thrombolysis in occluded cold stored venous allografts. The aim was to evaluate early outcomes, secondary patency and limb salvage rates of thrombolysed cold stored venous allograft bypasses and to compare the outcomes with thrombolysis of autologous bypasses.... περισσότερα »
Three-dimensional Ultrasound in the Management of Abdominal Aortic Aneurysms: A Topical Review
Publication date: Available online 18 July 2016 *Source:*European Journal of Vascular and Endovascular Surgery Author(s): C. Lowe, Q. Ghulam, K. Bredahl, S. Rogers, J. Ghosh, H. Sillesen, C.N. McCollum, J. Eiberg Three-dimensional (3D) ultrasound is an evolving modality that may have numerous applications in the management of abdominal aortic aneurysms. Many vascular specialists will not be familiar with the different ways in which 3D vascular ultrasound data can be acquired nor how potential applications are being explored by researchers. Most of the current literature consists of ... περισσότερα »
Melanoma Research – Current Issue
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Laryngo-Rhino-Otologie
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Vascular responsiveness measured by tissue oxygen saturation reperfusion slope is sensitive to different occlusion durations and training status
The reperfusion rate of near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2) represent vascular responsiveness. This study examined if the reperfusion slope of StO2 is sensitive to different ischemic conditions (i.e., a dose-response) and if differences exist between two groups of different fitness levels. Nine healthy trained (T; Age: 25 ± 3 yr; VO2max:… Continue reading Vascular responsiveness measured by tissue oxygen saturation reperfusion slope is sensitive to different occlusion durations and training status
Journal of the Association for Research in Otolaryngology
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Journal of Neurological Surgery Part B: Skull Base
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European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology – Head and Neck Surgery Author(s):Eur opean Federation of Oto-Rhino-Laryngological SocietiesDeutsche Gesellschaft für Hals-Nasen-Ohrenheilkunde Kopf- und Halsch irurgie
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JAMA Otolaryngology–Head & Neck Surgery Online First
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HNO
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Head & Neck
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European Archives of Oto-Rhino-Laryngology
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Epidemiology of onychomycosis in Crete, Greece: a 12-year study
Summary Onychomycosis is a chronic fungal nail infection caused by dermatophytes, yeasts or non-dermatophyte moulds (NDMs). It occurs worldwide and accounts for about 50% of all nail disorders. The incidence of the disease and the prevalence of pathogens involved vary in different geographical areas and change with time. This study was undertaken to determine the epidemiology of onychomycosis in Crete, Greece during a 12-year period. Mycologic nail investigation (direct microscopy and cultures) was performed in samples taken from 3417 patients with clinical suspicion of onychomycos... περισσότερα »
Molecular identification and phylogenetical analysis of dermatophyte fungi from Latin America
Summary Dermatophytes constitute a complex group of fungi, comprised of by the genera *Trichophyton*, *Epidermophyton* and *Microsporum*. They have the ability to degrade keratin and cause human and animal infections. Molecular techniques have made their identification faster and more accurate, and allowed important advances in phylogenetic studies. We aim to identify molecularly and to determine the phylogenetic relationships in dermatophyte fungi from Brazil and other Latin American countries, using DNA sequencing of the nuclear ribosome regions ITS1-5.8S-ITS2 and D1/D2. DNA of 4... περισσότερα »
Expression of the genes encoding the CasK/R two-component system and the DesA desaturase during Bacillus cereus cold adaptation
Two-component systems (TCS) allow a cell to elaborate a variety of adaptive responses to environment changes. The recently discovered CasK/R TCS plays a role in the optimal unsaturation of fatty acids necessary for cold adaptation of the foodborne pathogen *Bacillus cereus*. Here, we showed that the promoter activity of the operon encoding this TCS was repressed during growth at low temperature in the stationary phase in the parental strain when compared to the *casK/R* mutant, suggesting that CasR negatively regulates the activity of its own promoter in these conditions. The prom... περισσότερα »
Beyond the single answer: A process-oriented exam for science students
This commentary describes an assessment exercise known as the TRIPSE (Tri-Partite Problem Solving Exercise) that mimics science in operation. Students frame hypotheses based on limited data, design experiments to test them, which they later revise with new information. It is emphasised that there are no single correct answers, only sets with varying degrees of plausibility. The approach is flexible and can be adapted to any of the basic biomedical sciences and for students at multiple levels, undergraduate to graduate. In comparison to other testing methods, this process-oriented ... περισσότερα »
Epidemiology of onychomycosis in Crete, Greece: a 12-year study
Summary Onychomycosis is a chronic fungal nail infection caused by dermatophytes, yeasts or non-dermatophyte moulds (NDMs). It occurs worldwide and accounts for about 50% of all nail disorders. The incidence of the disease and the prevalence of pathogens involved vary in different geographical areas and change with time. This study was undertaken to determine the epidemiology of onychomycosis in Crete, Greece during a 12-year period. Mycologic nail investigation (direct microscopy and cultures) was performed in samples taken from 3417 patients with clinical suspicion of onychomycos... περισσότερα »
Molecular identification and phylogenetical analysis of dermatophyte fungi from Latin America
Summary Dermatophytes constitute a complex group of fungi, comprised of by the genera *Trichophyton*, *Epidermophyton* and *Microsporum*. They have the ability to degrade keratin and cause human and animal infections. Molecular techniques have made their identification faster and more accurate, and allowed important advances in phylogenetic studies. We aim to identify molecularly and to determine the phylogenetic relationships in dermatophyte fungi from Brazil and other Latin American countries, using DNA sequencing of the nuclear ribosome regions ITS1-5.8S-ITS2 and D1/D2. DNA of 4... περισσότερα »
A systematic review on methods used to evaluate patient preferences in psoriasis treatments
Abstract In the treatment of psoriasis and psoriatic arthritis, recently approved medications undergo the 'early benefit assessment' in Germany. Psoriasis treatments differ in a multiplicity of characteristics like side-effects, beneficial effect, cost and process attributes, which serve to evaluate the patient-relevant benefit compared to standard treatments. Patient preferences might help to aggregate the various patient-relevant outcomes into a single measure. In this context, besides the calculation of the quality-adjusted life-years (QALYs), the Institute for Quality and Effi... περισσότερα »
Transcutaneous pneumatic injection of glucose solution: a morphometric evaluation of in vivo micropig skin and tissue-mimicking phantom
Background Needle-free, transcutaneous pneumatic injection systems can be used to deliver therapeutic solutions to targeted layers of skin in a minimally invasive manner. Methods To evaluate jet infiltration patterns and tissue reactions, 5% isotonic and 20% hypertonic glucose solutions were pneumatically injected into *in vivo* micropig skin. Gelatin TM phantom was additionally prepared to analyze penetration and dispersion patterns for different experimental settings. Results As immediate tissue reactions in the *in vivo* micropig skin, distinct pneumatic injection injury zon... περισσότερα »
Reflectance confocal microscopy of Pigmented Bowen's disease: misleading dendritic cells
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Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy.
Objectives: To extend our understanding of how interindividual variability mediates the efficacy of cancer treatment. Materials and methods: The kinetics of dacarbazine (DTIC) N-demethylation by the most frequent polymorphic variants of CYP1A1 (T461N, I462V) and CYP1A2 (F186L, D348N, I386F, R431W, R456H) were characterized, along with kinetic parameters for the O-deethylation of the prototypic CYP1A substrate 7-ethoxyresorufin, using recombinant protein expression and high-performance liquid chromatographic techniques. Results: A reduction of ~30% in the catalytic efficiencies (meas... περισσότερα »
Pipeline Embolization Device for Recurrent Cerebral Aneurysms after Microsurgical Clipping
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 34 δευτερόλεπτα
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Nimer Adeeb, Christoph J. Griessenauer, Justin Moore, Christopher J. Stapleton, Aman B. Patel, Raghav Gupta, Apar S. Patel, Ajith J. Thomas, Christopher S. Ogilvy BackgroundMicrosurgical clipping is regarded as the most durable treatment for cerebral aneurysms. Aneurysm recurrence after clipping is uncommon and is associated with an increased risk of rupture. Reoperation for recurrent cerebral aneurysms is particularly challenging because of adhesions and scaring, and it carries... περισσότερα »
Association Between Comorbidities, Nutritional Status, and Anticlotting Drugs and Neurologic Outcomes in Geriatric Patients with Traumatic Brain Injury
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 34 δευτερόλεπτα
[image: alertIcon.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Tomoya Okazaki, Toru Hifumi, Kenya Kawakita, Ryuta Nakashima, Atsushi Matsumoto, Hajime Shishido, Daiske Ogawa, Masanobu Okauchi, Atsushi Shindo, Masahiko Kawanishi, Takashi Tamiya, Yasuhiro Kuroda BackgroundSeveral studies using trauma data banks and registers showed that age, Glasgow Coma Scale (GCS), Injury Severity Score, and intraventricular hemorrhage were independent factors for neurologic outcomes in geriatric patients with traumatic brain injury (TBI). However, these ana... περισσότερα »
Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 34 δευτερόλεπτα
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Dorothee Cäcilia Spille, Katharina Heß, Cristina Sauerland, Nader Sanai, Walter Stummer, Werner Paulus, Benjamin Brokinkel ObjectiveIn meningioma, correlation of brain invasion with prognosis and clinical variables remains controversial.MethodsCorrelation of brain invasion with clinical and histopathologic variables was investigated in 467 patients with primary intracranial meningioma.ResultsDiffuse (n = 3; 10%), clusterlike (n = 11; 34%) or fingerlike (n = 18; 56%) invasion was ... περισσότερα »
Acitretin: Monotherapy or Combined Therapy for Hidradenitis Suppurativa?
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 34 δευτερόλεπτα
Background: Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory disease of the pilosebaceous follicle that severely affects patients’ quality of life and can be challenging for clinicians to manage. A few case series have reported on the efficacy of acitretin monotherapy in the treatment of intractable HS. Objective: To assess the efficacy of acitretin for the treatment of intractable HS. Methods: A retrospective review was conducted involving all patients with HS who received acitretin between January 2011 and January 2015 in a tertiary academic medical center. All ... περισσότερα »
Head and Neck on PubMed
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Case Reports in Otolaryngology
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Acta Otorrinolaringológica Española
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Clinical Oral Investigations
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BMC Oral Health
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Lasers in Surgery and Medicine
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Journal of Esthetic and Restorative Dentistry
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Mutant IDH1-driven «Hit and Run» Gliomagenesis
Missense mutations in the active site of isocitrate dehydrogenase 1 (IDH1) biologically and diagnostically distinguish low-grade gliomas and secondary glioblastomas from primary glioblastomas. IDH1 mutations lead to the formation of the oncometabolite 2-hydroxyglutarate (2-HG) from the reduction of alpha-ketoglutarate (alpha-KG), which in turn facilitates tumorigenesis by modifying DNA and histone methylation as well blocking differentiation… Continue reading Mutant IDH1-driven «Hit and Run» Gliomagenesis
MFG-E8 Promotes MSC-Induced Angiogenesis and TAM in Melanoma
Secretion of the powerful angiogenic factor MFG-E8 by pericytes can bypass the therapeutic effects of anti-VEGF therapy, but the mechanisms by which MFG-E8 acts are not fully understood. In this study, we investigated how this factor acts to promote the growth of melanomas that express it. We found that mouse bone marrow–derived mesenchymal stromal cells… Continue reading MFG-E8 Promotes MSC-Induced Angiogenesis and TAM in Melanoma
Adipocyte Exosomes: A New Link between Obesity and Cancer
Malignant progression results from a dynamic cross-talk between stromal and cancer cells. Recent evidence suggests that this cross-talk is mediated to a significant extent by exosomes, nanovesicles secreted by most cell types and which allow the transfer of proteins, lipids, and nucleic acids between cells. Adipocytes are a major component of several tumor microenvironments, including… Continue reading Adipocyte Exosomes: A New Link between Obesity and Cancer
Vascular responsiveness measured by tissue oxygen saturation reperfusion slope is sensitive to different occlusion durations and training status
The reperfusion rate of near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2) represent vascular responsiveness. This study examined if the reperfusion slope of StO2 is sensitive to different ischemic conditions (i.e., a dose-response) and if differences exist between two groups of different fitness levels. Nine healthy trained (T; Age: 25 ± 3 yr; VO2max: 63.4 ± 6.7 ml kg−1 min−1) and nine healthy untrained (UT; Age: 21 ± 1 yr; VO2max: 46.6 ± 2.5 ml kg−1 min−1) men performed a series of vascular occlusion tests of different durations (30 s, 1 min, 2... περισσότερα »
Differential Paradigms in Animal Models of Sepsis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Abstract Sepsis is a serious clinical problem involving complex mechanisms which requires better understanding and insight. Animal models of sepsis have played a major role in providing insight into the complex pathophysiology of sepsis. There have been various animal models of sepsis with different paradigms. Endotoxin, bacterial infusion, cecal ligation and puncture, and colon ascendens stent peritonitis models are the commonly practiced methods at present. Each of these models has their own advantages and also confounding factors. We have discussed the underlying mechanisms regu... περισσότερα »
Expression of the genes encoding the CasK/R two-component system and the DesA desaturase during Bacillus cereus cold adaptation
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Two-component systems (TCS) allow a cell to elaborate a variety of adaptive responses to environment changes. The recently discovered CasK/R TCS plays a role in the optimal unsaturation of fatty acids necessary for cold adaptation of the foodborne pathogen *Bacillus cereus*. Here, we showed that the promoter activity of the operon encoding this TCS was repressed during growth at low temperature in the stationary phase in the parental strain when compared to the *casK/R* mutant, suggesting that CasR negatively regulates the activity of its own promoter in these conditions. The prom... περισσότερα »
Beyond the single answer: A process-oriented exam for science students
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
This commentary describes an assessment exercise known as the TRIPSE (Tri-Partite Problem Solving Exercise) that mimics science in operation. Students frame hypotheses based on limited data, design experiments to test them, which they later revise with new information. It is emphasised that there are no single correct answers, only sets with varying degrees of plausibility. The approach is flexible and can be adapted to any of the basic biomedical sciences and for students at multiple levels, undergraduate to graduate. In comparison to other testing methods, this process-oriented ... περισσότερα »
Oral Diseases
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
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Archives of Oral Biology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
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Journal of Cranio-Maxillofacial Surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
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Human papillomavirus (HPV) infections
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
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Human papillomavirus (HPV) infections
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
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Audiology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
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Allergy
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
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Current Opinion in Allergy and Clinical Immunology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 54 δευτερόλεπτα
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Clinical Oral Investigations
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BMC Oral Health
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Journal of Esthetic and Restorative Dentistry
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Journal of Endodontics
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International Endodontic Journal
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Edward H. Angle Society of Orthodontists: The Angle Orthodontist
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The Angle orthodontist,www.angleorthodontist.org
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International Journal of Oral and Maxillofacial Surgery
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International Journal of Oral and Maxillofacial Surgery
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Journal of Dental and Allied Sciences
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European Journal of Oral Sciences
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Cancer Origin sites
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
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Hormone therapy
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
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Immunoglobulin G
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
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Immunostimulants
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
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Infectious Diseases
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
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IntraMed
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 59 δευτερόλεπτα
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Vaccines, Vol. 4, Pages 24: Factors that Influence the Immunological Adjuvant Effect of Lactobacillus fermentum PC1 on Specific Immune Responses in Mice to Orally Administered Antigens
This study examined the influences of the dosage of the adjuvant, the nature of the antigen and the host genetics on the capacity of L. fermentum PC1 (PC1) to function as an oral adjuvant. BALB/c and DBA/1 mice were vaccinated with either ovalbumin (OVA) or Salmonella Typhimurium on days 0 and 14, Mice were also… Continue reading Vaccines, Vol. 4, Pages 24: Factors that Influence the Immunological Adjuvant Effect of Lactobacillus fermentum PC1 on Specific Immune Responses in Mice to Orally Administered Antigens
For Autoimmune Ills, Biologics Bring Promise—and Problems – Managed Care magazine
Managed Care magazine For Autoimmune Ills, Biologics Bring Promise—and Problems Managed Care magazine … inflammatory bowel disease to the rare and obscure like pemphigus, a group of autoimmune diseases that cause blistering of the skin and mucous membranes, and granulomatosis with polyangiitis (also called Wegener’s) that causes inflammation of the … from #ORL-AlexandrosSfakianakis via simeraentaxei… Continue reading For Autoimmune Ills, Biologics Bring Promise—and Problems – Managed Care magazine
TRAP1 and SDH as Therapeutic Targets of HCC
S-nitrosoglutathione reductase (GSNOR) represents the best-documented denitrosylase implicated in regulating the levels of proteins posttranslationally modified by nitric oxide on cysteine residues by S-nitrosylation. GSNOR controls a diverse array of physiologic functions, including cellular growth and differentiation, inflammation, and metabolism. Chromosomal deletion of GSNOR results in pathologic protein S-nitrosylation that is implicated in human hepatocellular… Continue reading TRAP1 and SDH as Therapeutic Targets of HCC
Year 1993 in Colon Cancer Genetics
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Targeting a Glycolysis HIF-1 Feed-Forward Loop
The hypoxia-inducible transcription factor HIF1α drives expression of many glycolytic enzymes. Here, we show that hypoxic glycolysis, in turn, increases HIF1α transcriptional activity and stimulates tumor growth, revealing a novel feed-forward mechanism of glycolysis-HIF1α signaling. Negative regulation of HIF1α by AMPK1 is bypassed in hypoxic cells, due to ATP elevation by increased glycolysis, thereby preventing… Continue reading Targeting a Glycolysis HIF-1 Feed-Forward Loop
Biology of H. pylori CagA
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K14 HPV49 E6/E7 Transgenic Mice
The beta genus of human papillomaviruses (ß-HPV) includes approximately 50 different viral types that are subdivided into five species (ß-1 through ß-5). Nonmelanoma cancers may involve some ß-1 and ß-2 HPV types, but the biology of most ß-HPV types and their possible connections to human disease are still little characterized. In this study, we studied… Continue reading K14 HPV49 E6/E7 Transgenic Mice
Exercise in Cancer Initiation, Progression, and Metastasis
A major objective of the emerging field of exercise–oncology research is to determine the efficacy of, and biological mechanisms by which, aerobic exercise affects cancer incidence, progression, and/or metastasis. There is a strong inverse association between self-reported exercise and the primary incidence of several forms of cancer; similarly, emerging data suggest that exercise exposure after… Continue reading Exercise in Cancer Initiation, Progression, and Metastasis
Oncology
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Highlights from Recent Cancer Literature
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Expression of the genes encoding the CasK/R two-component system and the DesA desaturase during Bacillus cereus cold adaptation
Two-component systems (TCS) allow a cell to elaborate a variety of adaptive responses to environment changes. The recently discovered CasK/R TCS plays a role in the optimal unsaturation of fatty acids necessary for cold adaptation of the foodborne pathogen *Bacillus cereus*. Here, we showed that the promoter activity of the operon encoding this TCS was repressed during growth at low temperature in the stationary phase in the parental strain when compared to the *casK/R* mutant, suggesting that CasR negatively regulates the activity of its own promoter in these conditions. The prom... περισσότερα »
Beyond the single answer: A process-oriented exam for science students
This commentary describes an assessment exercise known as the TRIPSE (Tri-Partite Problem Solving Exercise) that mimics science in operation. Students frame hypotheses based on limited data, design experiments to test them, which they later revise with new information. It is emphasised that there are no single correct answers, only sets with varying degrees of plausibility. The approach is flexible and can be adapted to any of the basic biomedical sciences and for students at multiple levels, undergraduate to graduate. In comparison to other testing methods, this process-oriented ... περισσότερα »
MFG-E8 Promotes MSC-Induced Angiogenesis and TAM in Melanoma
Secretion of the powerful angiogenic factor MFG-E8 by pericytes can bypass the therapeutic effects of anti-VEGF therapy, but the mechanisms by which MFG-E8 acts are not fully understood. In this study, we investigated how this factor acts to promote the growth of melanomas that express it. We found that mouse bone marrow–derived mesenchymal stromal cells (MSC) expressed a substantial amount of MFG-E8. To assess its expression from this cell type, we implanted melanoma cells and MSC derived from wild type (WT) or MFG-E8 deficient [knockout (KO)] into mice and monitored tumor growth... περισσότερα »
Adipocyte Exosomes: A New Link between Obesity and Cancer
Malignant progression results from a dynamic cross-talk between stromal and cancer cells. Recent evidence suggests that this cross-talk is mediated to a significant extent by exosomes, nanovesicles secreted by most cell types and which allow the transfer of proteins, lipids, and nucleic acids between cells. Adipocytes are a major component of several tumor microenvironments, including that of invasive melanoma, where cells have migrated to the adipocyte-rich hypodermic layer of the skin. We show that adipocytes secrete exosomes in abundance, which are then taken up by tumor cells, ... περισσότερα »
MFG-E8 Promotes MSC-Induced Angiogenesis and TAM in Melanoma
Secretion of the powerful angiogenic factor MFG-E8 by pericytes can bypass the therapeutic effects of anti-VEGF therapy, but the mechanisms by which MFG-E8 acts are not fully understood. In this study, we investigated how this factor acts to promote the growth of melanomas that express it. We found that mouse bone marrow–derived mesenchymal stromal cells (MSC) expressed a substantial amount of MFG-E8. To assess its expression from this cell type, we implanted melanoma cells and MSC derived from wild type (WT) or MFG-E8 deficient [knockout (KO)] into mice and monitored tumor growth... περισσότερα »
Adipocyte Exosomes: A New Link between Obesity and Cancer
Malignant progression results from a dynamic cross-talk between stromal and cancer cells. Recent evidence suggests that this cross-talk is mediated to a significant extent by exosomes, nanovesicles secreted by most cell types and which allow the transfer of proteins, lipids, and nucleic acids between cells. Adipocytes are a major component of several tumor microenvironments, including that of invasive melanoma, where cells have migrated to the adipocyte-rich hypodermic layer of the skin. We show that adipocytes secrete exosomes in abundance, which are then taken up by tumor cells, ... περισσότερα »
MFG-E8 Promotes MSC-Induced Angiogenesis and TAM in Melanoma
Secretion of the powerful angiogenic factor MFG-E8 by pericytes can bypass the therapeutic effects of anti-VEGF therapy, but the mechanisms by which MFG-E8 acts are not fully understood. In this study, we investigated how this factor acts to promote the growth of melanomas that express it. We found that mouse bone marrow–derived mesenchymal stromal cells (MSC) expressed a substantial amount of MFG-E8. To assess its expression from this cell type, we implanted melanoma cells and MSC derived from wild type (WT) or MFG-E8 deficient [knockout (KO)] into mice and monitored tumor growth... περισσότερα »
Adipocyte Exosomes: A New Link between Obesity and Cancer
Malignant progression results from a dynamic cross-talk between stromal and cancer cells. Recent evidence suggests that this cross-talk is mediated to a significant extent by exosomes, nanovesicles secreted by most cell types and which allow the transfer of proteins, lipids, and nucleic acids between cells. Adipocytes are a major component of several tumor microenvironments, including that of invasive melanoma, where cells have migrated to the adipocyte-rich hypodermic layer of the skin. We show that adipocytes secrete exosomes in abundance, which are then taken up by tumor cells, ... περισσότερα »
Pipeline Embolization Device for Recurrent Cerebral Aneurysms after Microsurgical Clipping
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Nimer Adeeb, Christoph J. Griessenauer, Justin Moore, Christopher J. Stapleton, Aman B. Patel, Raghav Gupta, Apar S. Patel, Ajith J. Thomas, Christopher S. Ogilvy BackgroundMicrosurgical clipping is regarded as the most durable treatment for cerebral aneurysms. Aneurysm recurrence after clipping is uncommon and is associated with an increased risk of rupture. Reoperation for recurrent cerebral aneurysms is particularly challenging because of adhesions and scaring, and it carries... περισσότερα »
Association Between Comorbidities, Nutritional Status, and Anticlotting Drugs and Neurologic Outcomes in Geriatric Patients with Traumatic Brain Injury
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Tomoya Okazaki, Toru Hifumi, Kenya Kawakita, Ryuta Nakashima, Atsushi Matsumoto, Hajime Shishido, Daiske Ogawa, Masanobu Okauchi, Atsushi Shindo, Masahiko Kawanishi, Takashi Tamiya, Yasuhiro Kuroda BackgroundSeveral studies using trauma data banks and registers showed that age, Glasgow Coma Scale (GCS), Injury Severity Score, and intraventricular hemorrhage were independent factors for neurologic outcomes in geriatric patients with traumatic brain injury (TBI). However, these ana... περισσότερα »
Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Dorothee Cäcilia Spille, Katharina Heß, Cristina Sauerland, Nader Sanai, Walter Stummer, Werner Paulus, Benjamin Brokinkel ObjectiveIn meningioma, correlation of brain invasion with prognosis and clinical variables remains controversial.MethodsCorrelation of brain invasion with clinical and histopathologic variables was investigated in 467 patients with primary intracranial meningioma.ResultsDiffuse (n = 3; 10%), clusterlike (n = 11; 34%) or fingerlike (n = 18; 56%) invasion was ... περισσότερα »
Influences of Schneiderian membrane conditions on the early outcomes of osteotome sinus floor elevation technique: a prospective cohort study in the healing period
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Abstract Objectives To radiographically investigate early outcomes of osteotome sinus floor elevation in the healing phase utilizing cone beam computed tomography and evaluate influences of Schneiderian membrane conditions. Material and methods One hundred patients were consecutively recruited for osteotome sinus floor elevation (OSFE) surgery using deproteinized bone mineral. CBCT was taken prior to (*T*0), immediately post-operatively (*T*1), and after the healing period (*T*2). Linear and volumetric measurements of the elevated region from *T*0 to *T*1 were performed for evalu... περισσότερα »
Hydrogen Sulfide Regulates Homeostasis of Mesenchymal Stem Cells and Regulatory T Cells
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Hydrogen sulfide (H2S) has long been known as a toxic gas. However, recently accumulated evidence suggests that H2S contributes to a variety of physiologic and pathologic processes. Endogenous H2S production is regulated by multiple enzymes that are differentially expressed in the cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems. Alteration of H2S metabolism may affect multiple signaling pathways and tissue homeostasis. The growing number of diverse targets for which H2S serves as a gasotransmitter has been extensiv... περισσότερα »
Audiology
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Facial Plastic Surgery Clinics
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Head and Neck on PubMed
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Immunoglobulin E
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Anticipatory mouth opening during eating
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Journal of Oral Rehabilitation Δευτέρα, 1 Αυγούστου 2016, 8:00:00 πμ Effects of age and non-oropharyngeal proprioceptive and exteroceptive sensation on the magnitude of anticipatory mouth opening during eating S. E. Shune, J. B. Moon Summary To best prevent and treat eating/swallowing problems, it is essential to understand how components of oral physiology contribute to the […]
The larynx
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Nose
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Nose
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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OtoRhinoLaryngology – Head and Neck Surgery 200 citation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Clinics in Plastic Surgery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed!Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! ScienceDirect Publication: Clinics in Plastic […]
Acitretin: Monotherapy or Combined Therapy for Hidradenitis Suppurativa?
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory disease of the pilosebaceous follicle that severely affects patients’ quality of life and can be challenging for clinicians to manage. A few case series have reported on the efficacy of acitretin monotherapy in the treatment of intractable HS. Objective: To assess the efficacy of acitretin for […]
Allergy
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Current Opinion in Allergy and Clinical Immunology
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Facial Plastic Surgery Clinics
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Head and Neck on PubMed
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Immunoglobulin E
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Anticipatory mouth opening during eating
Journal of Oral Rehabilitation Δευτέρα, 1 Αυγούστου 2016, 8:00:00 πμ Effects of age and non-oropharyngeal proprioceptive and exteroceptive sensation on the magnitude of anticipatory mouth opening during eating S. E. Shune, J. B. Moon Summary To best prevent and treat eating/swallowing problems, it is essential to understand how components of oral physiology contribute to the preservation and/or degradation of eating/swallowing in healthy ageing. Anticipatory, pre-swallow motor movements may be critical to safe and efficient eating/swallowing, particularly for older adults. Howev... περισσότερα »
The larynx
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Nose
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Pipeline Embolization Device for Recurrent Cerebral Aneurysms after Microsurgical Clipping
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Nimer Adeeb, Christoph J. Griessenauer, Justin Moore, Christopher J. Stapleton, Aman B. Patel, Raghav Gupta, Apar S. Patel, Ajith J. Thomas, Christopher S. Ogilvy BackgroundMicrosurgical clipping is regarded as the most durable treatment for cerebral aneurysms. Aneurysm recurrence after clipping is uncommon and is associated with an increased risk of rupture. Reoperation for recurrent cerebral aneurysms is particularly challenging because of adhesions and scaring, and it carries... περισσότερα »
Association Between Comorbidities, Nutritional Status, and Anticlotting Drugs and Neurologic Outcomes in Geriatric Patients with Traumatic Brain Injury
[image: alertIcon.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Tomoya Okazaki, Toru Hifumi, Kenya Kawakita, Ryuta Nakashima, Atsushi Matsumoto, Hajime Shishido, Daiske Ogawa, Masanobu Okauchi, Atsushi Shindo, Masahiko Kawanishi, Takashi Tamiya, Yasuhiro Kuroda BackgroundSeveral studies using trauma data banks and registers showed that age, Glasgow Coma Scale (GCS), Injury Severity Score, and intraventricular hemorrhage were independent factors for neurologic outcomes in geriatric patients with traumatic brain injury (TBI). However, these ana... περισσότερα »
Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis
[image: S18788750.gif] Publication date: September 2016 *Source:*World Neurosurgery, Volume 93 Author(s): Dorothee Cäcilia Spille, Katharina Heß, Cristina Sauerland, Nader Sanai, Walter Stummer, Werner Paulus, Benjamin Brokinkel ObjectiveIn meningioma, correlation of brain invasion with prognosis and clinical variables remains controversial.MethodsCorrelation of brain invasion with clinical and histopathologic variables was investigated in 467 patients with primary intracranial meningioma.ResultsDiffuse (n = 3; 10%), clusterlike (n = 11; 34%) or fingerlike (n = 18; 56%) invasion was ... περισσότερα »
Discovery and Functional Annotation of PRSS1 Promoter Variants in Chronic Pancreatitis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
ABSTRACT Recently, our resequencing of the promoter region of PRSS1 in French Caucasian individuals led to the identification of a functional variant (c.-204C>A) that is in perfect linkage disequilibrium with the ‘chronic pancreatitis (CP)-protective’ PRSS1 c.-408C>T variant. Here, we extended the resequencing to 626 French Caucasians (242 idiopathic CP patients and 384 controls). We discovered […]
Development of the Life Story in Early Adolescence
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Life span developmental psychology proposes that the ability to create a coherent life narrative does not develop until early adolescence. Using a novel methodology, 10-, 12-, and 14-year-old participants were asked to tell their life stories aloud to a researcher. Later, participants separated their transcribed narratives into self-identified chapters. When life stories were assessed with […]
Metformin and prostate cancer risk
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Previous studies on the relationship between metformin therapy and prostate cancer risk have yielded conflicting results. Cancer researchers are not sure how to explain these findings. In recent years, new evidence suggested that the effect of metformin on prostate cancer risk might vary in different ethnicities. As we enter the era of precision medicine, to […]
Celecoxib modulates the GI microbiota and metabolome
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Treatment with celecoxib, a selective COX-2 inhibitor, reduces formation of premalignant adenomatous polyps in the gastrointestinal tracts of humans and mice. In addition to its chemopreventive activity, celecoxib can exhibit anti-microbial activity. Differing bacterial profiles have been found in feces from colon cancer patients compared with that of normal subjects. Moreover, preclinical studies suggest that […]
Role of the CYFIP1-NCKAP1 complex in metastasis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Inactivation of the WASF3 gene suppresses invasion and metastasis of breast cancer cells. WASF3 function is regulated through a protein complex that includes the NCKAP1 and CYFIP1 proteins. Here we report that silencing NCKAP1 destabilizes the WASF3 complex, resulting in a suppression of the invasive capacity of breast, prostate and colon cancer cells. In an […]
Mobile Genetic Elements in Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Approximately half of the human genome consists of repetitive sequence attributed to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retroviruses. Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today. Although cells restrict L1 activity by both transcriptional and posttranscriptional […]
Toward the integration of Omics data in epidemiological studies: still a “long and winding road”
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
ABSTRACT Primary and secondary prevention can highly benefit a personalized medicine approach through the accurate discrimination of individuals at high risk of developing a specific disease from those at moderate and low risk. To this end precise risk prediction models need to be built. This endeavor requires a precise characterization of the individual exposome, genome, […]
TRAP1 and SDH as Therapeutic Targets of HCC
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
S-nitrosoglutathione reductase (GSNOR) represents the best-documented denitrosylase implicated in regulating the levels of proteins posttranslationally modified by nitric oxide on cysteine residues by S-nitrosylation. GSNOR controls a diverse array of physiologic functions, including cellular growth and differentiation, inflammation, and metabolism. Chromosomal deletion of GSNOR results in pathologic protein S-nitrosylation that is implicated in human hepatocellular […]
Year 1993 in Colon Cancer Genetics
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/2a6BbB9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Targeting a Glycolysis HIF-1 Feed-Forward Loop
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The hypoxia-inducible transcription factor HIF1α drives expression of many glycolytic enzymes. Here, we show that hypoxic glycolysis, in turn, increases HIF1α transcriptional activity and stimulates tumor growth, revealing a novel feed-forward mechanism of glycolysis-HIF1α signaling. Negative regulation of HIF1α by AMPK1 is bypassed in hypoxic cells, due to ATP elevation by increased glycolysis, thereby preventing […]
Influences of Schneiderian membrane conditions on the early outcomes of osteotome sinus floor elevation technique: a prospective cohort study in the healing period
Abstract Objectives To radiographically investigate early outcomes of osteotome sinus floor elevation in the healing phase utilizing cone beam computed tomography and evaluate influences of Schneiderian membrane conditions. Material and methods One hundred patients were consecutively recruited for osteotome sinus floor elevation (OSFE) surgery using deproteinized bone mineral. CBCT was taken prior to (*T*0), immediately post-operatively (*T*1), and after the healing period (*T*2). Linear and volumetric measurements of the elevated region from *T*0 to *T*1 were performed for evalu... περισσότερα »
Hydrogen Sulfide Regulates Homeostasis of Mesenchymal Stem Cells and Regulatory T Cells
Hydrogen sulfide (H2S) has long been known as a toxic gas. However, recently accumulated evidence suggests that H2S contributes to a variety of physiologic and pathologic processes. Endogenous H2S production is regulated by multiple enzymes that are differentially expressed in the cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems. Alteration of H2S metabolism may affect multiple signaling pathways and tissue homeostasis. The growing number of diverse targets for which H2S serves as a gasotransmitter has been extensiv... περισσότερα »
Influences of Schneiderian membrane conditions on the early outcomes of osteotome sinus floor elevation technique: a prospective cohort study in the healing period
Abstract Objectives To radiographically investigate early outcomes of osteotome sinus floor elevation in the healing phase utilizing cone beam computed tomography and evaluate influences of Schneiderian membrane conditions. Material and methods One hundred patients were consecutively recruited for osteotome sinus floor elevation (OSFE) surgery using deproteinized bone mineral. CBCT was taken prior to (*T*0), immediately post-operatively (*T*1), and after the healing period (*T*2). Linear and volumetric measurements of the elevated region from *T*0 to *T*1 were performed for evaluati... περισσότερα »
Hydrogen Sulfide Regulates Homeostasis of Mesenchymal Stem Cells and Regulatory T Cells
Hydrogen sulfide (H2S) has long been known as a toxic gas. However, recently accumulated evidence suggests that H2S contributes to a variety of physiologic and pathologic processes. Endogenous H2S production is regulated by multiple enzymes that are differentially expressed in the cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems. Alteration of H2S metabolism may affect multiple signaling pathways and tissue homeostasis. The growing number of diverse targets for which H2S serves as a gasotransmitter has been extensiv... περισσότερα »
Oncology
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Radiation Therapy
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Radiofrequency (RF) ablation
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Rathiotherapy
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Respiratory Care
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Respiratory
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Risk factors for cancer
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Journal of Environmental Radioactivity
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Rehabilitation
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
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Speech
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
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Swallowing and Swallowing Disorders (Dysphagia)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed!Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! Swallowing and Swallowing Disorders (Dysphagia) […]
Physiology
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Acitretin: Monotherapy or Combined Therapy for Hidradenitis Suppurativa?
Acitretin: Monotherapy or Combined Therapy for Hidradenitis Suppurativa?: Background: Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory disease of the pilosebaceous follicle that severely affects patients’ quality of life and can be challenging for clinicians to manage. A few case series have reported on the efficacy of acitretin monotherapy in the treatment of intractable HS.… Continue reading Acitretin: Monotherapy or Combined Therapy for Hidradenitis Suppurativa?
MFG-E8 Promotes MSC-Induced Angiogenesis and TAM in Melanoma
MFG-E8 Promotes MSC-Induced Angiogenesis and TAM in Melanoma: Secretion of the powerful angiogenic factor MFG-E8 by pericytes can bypass the therapeutic effects of anti-VEGF therapy, but the mechanisms by which MFG-E8 acts are not fully understood. In this study, we investigated how this factor acts to promote the growth of melanomas that express it. We… Continue reading MFG-E8 Promotes MSC-Induced Angiogenesis and TAM in Melanoma
Adipocyte Exosomes: A New Link between Obesity and Cancer
Adipocyte Exosomes: A New Link between Obesity and Cancer: Malignant progression results from a dynamic cross-talk between stromal and cancer cells. Recent evidence suggests that this cross-talk is mediated to a significant extent by exosomes, nanovesicles secreted by most cell types and which allow the transfer of proteins, lipids, and nucleic acids between cells. Adipocytes… Continue reading Adipocyte Exosomes: A New Link between Obesity and Cancer
Vertigo
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Acitretin: Monotherapy or Combined Therapy for Hidradenitis Suppurativa?
Background: Hidradenitis suppurativa (HS) is a chronic, recurrent inflammatory disease of the pilosebaceous follicle that severely affects patients’ quality of life and can be challenging for clinicians to manage. A few case series have reported on the efficacy of acitretin monotherapy in the treatment of intractable HS. Objective: To assess the efficacy of acitretin for… Continue reading Acitretin: Monotherapy or Combined Therapy for Hidradenitis Suppurativa?
Tissue-resident and memory properties of human T-cell and NK-cell subsets
Efficient immune responses to invading pathogens are the result of the complex but coordinated synergy between a variety of cell types from both the innate and adaptive arms of the immune system. While adaptive and innate immune responses are highly complementary, some cells types within these two systems perform similar functions, underscoring the need for… Continue reading Tissue-resident and memory properties of human T-cell and NK-cell subsets
Year 1993 in Colon Cancer Genetics
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Targeting a Glycolysis HIF-1 Feed-Forward Loop
The hypoxia-inducible transcription factor HIF1α drives expression of many glycolytic enzymes. Here, we show that hypoxic glycolysis, in turn, increases HIF1α transcriptional activity and stimulates tumor growth, revealing a novel feed-forward mechanism of glycolysis-HIF1α signaling. Negative regulation of HIF1α by AMPK1 is bypassed in hypoxic cells, due to ATP elevation by increased glycolysis, thereby preventing… Continue reading Targeting a Glycolysis HIF-1 Feed-Forward Loop
TRAP1 and SDH as Therapeutic Targets of HCC
S-nitrosoglutathione reductase (GSNOR) represents the best-documented denitrosylase implicated in regulating the levels of proteins posttranslationally modified by nitric oxide on cysteine residues by S-nitrosylation. GSNOR controls a diverse array of physiologic functions, including cellular growth and differentiation, inflammation, and metabolism. Chromosomal deletion of GSNOR results in pathologic protein S-nitrosylation that is implicated in human hepatocellular… Continue reading TRAP1 and SDH as Therapeutic Targets of HCC
Vertigo
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Vascular responsiveness measured by tissue oxygen saturation reperfusion slope is sensitive to different occlusion durations and training status
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
The reperfusion rate of near-infrared spectroscopy (NIRS)-derived measures of tissue oxygen saturation (StO2) represent vascular responsiveness. This study examined if the reperfusion slope of StO2 is sensitive to different ischemic conditions (i.e., a dose-response) and if differences exist between two groups of different fitness levels. Nine healthy trained (T; Age: 25 ± 3 yr; VO2max: 63.4 ± 6.7 ml kg−1 min−1) and nine healthy untrained (UT; Age: 21 ± 1 yr; VO2max: 46.6 ± 2.5 ml kg−1 min−1) men performed a series of vascular occlusion tests of different durations (30 s, 1 min, ... περισσότερα »
Biochemical Characterization of β-Lactamases from Mycobacterium abscessus Complex and Genetic Environment of the β-Lactamase-Encoding Gene
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 ώρες
Microbial Drug Resistance , Vol. 0, No. 0. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/29RjIrq via IFTTT
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