[Standard of care of carcinomas on cancer of unknown primary site in 2016].
*[Standard of care of carcinomas on cancer of unknown primary site in 2016].* Bull Cancer. 2016 Jun 29; Authors: Benderra MA, Ilié M, Hofman P, Massard C Abstract Patients with Cancer of unknown primary (cup) represent 2-10%, and have disseminated cancers for which we cannot find the primary site despite the clinical, pathological and radiological exams at our disposal. Diagnosis is based on a thorough clinical and histopathologic examination as well as new imaging techniques. Several clinicopathologic entities requiring specific treatment can be identified. Genome sequencing and... περισσότερα »
Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models
Abstract Purpose NHS-IL12 is an immunocytokine targeting necrotic tumour areas. IL12 shows anti-tumour activity. As local irradiation might induce additional necrosis in solid tumours, we aimed to evaluate the increase in intratumoural accumulation of NHS-IL12 after irradiation and correlate the findings with diffusion-weighted MRI studies in two xenograft models. Methods Human rhabdomyosarcoma (A204) and prostate cancer (PC3) cells were studied in vitro and as subcutaneous xenografts. Radiation sensitivity of the cell lines was assessed in vitro by colony formation assays. In viv... περισσότερα »
Paraquat Poisoning Followed by Toxic Epidermal Necrolysis: A Report of Two Cases and Published Work Review.
[image: http:--misc.karger.com-LinkOutIcons-sk_n] Authors: Xu W, Wang L, Wang Q, Li XH, Hu D, Li C, Wu T, Mohan C, Peng A, Shi Y Abstract Toxic epidermal necrolysis (TEN) is a life-threatening, typically drug-induced, mucocutaneous disease. Whether paraquat, one of the most widely used herbicides, could induce TEN is not known. We describe 2 paraquat-poisoned patients with TEN. Both patients presented erythema after hospital discharge following initial paraquat poisoning and then developed a widespread eruption of diffuse erythema on almost the whole body, with bullae, epiderma... περισσότερα »
Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies
Abstract Background Littoral cell angioma (LCA) is a rare primary splenic tumor frequently associated with internal malignancies. Immunohistochemistry (IHC) can prove a distinct hybrid endothelial/histiocytic phenotype of littoral cells and is a helpful adjunct to render the correct diagnosis. We present a series of 25 LCA with an emphasis on the frequent association of the neoplasm with visceral malignancies and provide a detailed immunohistochemical analysis by employing new markers. Design All 25 cases with available tissue blocks were immunohistochemically stained for endot... περισσότερα »
Pore Network Simulations of Heat and Mass Transfer inside an Unsaturated Capillary Porous Wick in the Dry-out Regime
Abstract In this work, a two-dimensional pore network model is developed to study the heat and mass transfer inside a capillary porous wick with opposite replenishment in the dry-out regime. The mass flow rate in each throat of the pore network is computed according to the Hagen–Poiseuille law, and the heat flux is calculated based on Fourier's law with an effective local thermal conductivity. By coupling the heat and the mass transfer, a numerical method is devised to determine the evolution of the liquid–vapor interface. The model is verified by comparing the effective heat trans... περισσότερα »
The coupling of hemin with persistent free radicals induces nonradical mechanism for oxidation of pollutant
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC02973F, Communication Bin Jiang, Dejun Dai, YuYuan Yao, Tiefeng Xu, Renhong Li, Renjie Xie, Likun Chen, Wenxing Chen Herein, we report that persistent free radicals (PFRs) based on MWCNTs significantly accelerate the pollutant removal rate. EPR measurement combining with electrochemical test indicated that nonradical mechanism was responsible for... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29kIxij via IFTTT
Poly (vinyl alcohol)/chitosan cryogels as PH responsive ciprofloxacin carriers
Abstract The pH responsiveness of swelling behavior and the release of ciprofloxacin hydrochloride from poly (vinyl alcohol)/chitosan cryogels of various compositions were investigated. All cryogels swelled and reached equilibrium within 100 min, indicating that the cryogels swell relatively fast. Increasing the chitosan content in the poly (vinyl alcohol) cryogels increased the swelling capacity of the cryogels. The poly (vinyl alcohol)/chitosan cryogels exhibited a sudden change in swelling characteristics at a certain pH value of the swelling medium as critical pH of 6.37–6.68 ... περισσότερα »
A methodological, task-based approach to Procedure-Specific Simulations training
Abstract Purpose Procedure-Specific Simulations (PSS) are 3D realistic simulations that provide a platform to practice complete surgical procedures in a virtual-reality environment. While PSS have the potential to improve surgeons' proficiency, there are no existing standards or guidelines for PSS development in a structured manner. Method We employ a unique platform inspired by game design to develop virtual reality simulations in three dimensions of urethrovesical anastomosis during radical prostatectomy. 3D visualization is supported by a stereo vision, providing a fully reali... περισσότερα »
On-patient see-through augmented reality based on visual SLAM
Abstract Purpose An augmented reality system to visualize a 3D preoperative anatomical model on intra-operative patient is proposed. The hardware requirement is commercial tablet-PC equipped with a camera. Thus, no external tracking device nor artificial landmarks on the patient are required. Methods We resort to visual SLAM to provide markerless real-time tablet-PC camera location with respect to the patient. The preoperative model is registered with respect to the patient through 4–6 anchor points. The anchors correspond to anatomical references selected on the tablet-PC screen ... περισσότερα »
Subcranial craniofacial resection for advanced sinonasal malignant tumours involving the anterior skull base
Main Article Subcranial craniofacial resection for advanced sinonasal malignant tumours involving the anterior skull base C C Yonga1 c1, A Soni-Jaiswala2 and J J Homera1 a1 Department of Otolaryngology – Head and Neck Surgery, Manchester Academic Health Sciences Centre, Manchester Royal Infirmary, UK a2 Department of Otolaryngology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK Abstract Background: The subcranial approach is a modification of traditional craniofacial resection. It provides similar broad access to the anterior skull base, but with lower mortality... περισσότερα »
Environmental Disease
Progress in the studies on hormesis of low-dose pollutants by Junyi Shi via Environmental Disease : 2016 - 1(2) *Junyi Shi, Mitchell Huber, Ting Wang, Wang Dali, Zhifen Lin, Yin Chun-Sheng* Environmental Disease 2016 1(2):58-64 Hormesis can be defined as a biphasic dose-response relationship characterized by low-dose simulation and high-dose inhibition. Given that environmental pollutants are more often found at lower doses, hormesis research has become a recent hot spot in toxicology. This study summarizes current progress on hormesis research, which can be discussed in thr... περισσότερα »
Stoppa approach for intrapelvic damage control and reconstruction of complex acetabular defects with intra-pelvic socket migration: A case report.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 16 δευτερόλεπτα
*Stoppa approach for intrapelvic damage control and reconstruction of complex acetabular defects with intra-pelvic socket migration: A case report.* Int J Surg Case Rep. 2016 Jun 25;25:143-148 Authors: Murcia-Asensio A, Ferrero-Manzanal F, Lax-Pérez R, Fernández-Fairén M Abstract INTRODUCTION: Failed hip arthroplasty with intrapelvic acetabular migration can be challenging due to the potential damage of intrapelvic structures. PRESENTATION OF THE CASE: We present a case of a 75 year-old lady with failed hip arthroplasty with loosening of implants and intra-pelvic migration of the... περισσότερα »
Psoas muscle abscess simulating acute appendicits: A case report.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 16 δευτερόλεπτα
*Psoas muscle abscess simulating acute appendicits: A case report.* Int J Surg Case Rep. 2016 Jun 23;25:139-142 Authors: Miller EL, Miller LF, Carvalho JG, Marsillac A, Pires L, Babinski MA, Monteiro M Abstract INTRODUCTION: Psoas abscess is a rare clinical entity with vague symptomatology. We report a psoas abscess that simulated symptoms of acute appendicitis. PRESENTATION OF CASE: A twenty-five year old male presented pain irradiating to the right iliac fossa and lumbar region associated with thigh flexion. Laboratorial exams revealed leukocytosis with a neutrophil shift to th... περισσότερα »
Malignant chondroid syringoma in a West African cancer institute: A case report.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 16 δευτερόλεπτα
*Malignant chondroid syringoma in a West African cancer institute: A case report.* Int J Surg Case Rep. 2016 Jun 23;25:137-138 Authors: Ka S, Gnangnon F, Diouf D, Dieng MM, Thiam J, Gaye M, Dem A Abstract OBJECTIVE: To report a case of malignant chondroid syringoma, a rare skin tumor at Joliot Curie Cancer Institute in Dakar. RESULTS: We report a case of malignant chondroid syringoma of the deltoid and axilla in a 53year old patient. Malignant chondroid syringoma is an extremely rare tumor of the sweat glands. It is included in myoepithelial tumors of the skin. It has an epithelia... περισσότερα »
Spontaneous breast cancer remission: A case report.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 16 δευτερόλεπτα
*Spontaneous breast cancer remission: A case report.* Int J Surg Case Rep. 2016 Jun 25;25:132-136 Authors: Ito E, Nakano S, Otsuka M, Mibu A, Karikomi M, Oinuma T, Yamamoto M Abstract INTRODUCTION: Spontaneous breast cancer remission is a rare phenomenon. We report the disappearance from the remaining breast of a new primary carcinoma that had been confirmed through cytology of a pathological specimen, in a case that is strongly suspected to be spontaneous remission. PRESENTATION OF CASE: A 44-year-old woman underwent breast-conserving surgery for a tumor located on the border betw... περισσότερα »
Transurethral 160-W straight beam green laser vaporesection of the prostate: initial experience after 180 procedures
Although the photoselective vaporization of the prostate has been considered one of the most promising alternatives for treatment of benign prostatic hyperplasia (BPH), published clinical data with the surgica… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29gIJRV via IFTTT
Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies
Abstract Background Littoral cell angioma (LCA) is a rare primary splenic tumor frequently associated with internal malignancies. Immunohistochemistry (IHC) can prove a distinct hybrid endothelial/histiocytic phenotype of littoral cells and is a helpful adjunct to render the correct diagnosis. We present a series of 25 LCA with an emphasis on the frequent association of the… Continue reading Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies
Subcranial craniofacial resection for advanced sinonasal malignant tumours involving the anterior skull base
Research Articles C C Yong, A Soni-Jaiswal, J J Homer The Journal of Laryngology & Otology,FirstView Article(s), 6 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29dhu9A via IFTTT
Subcranial craniofacial resection for advanced sinonasal malignant tumours involving the anterior skull base
Research Articles C C Yong, A Soni-Jaiswal, J J Homer The Journal of Laryngology & Otology,FirstView Article(s), 6 pages Abstract from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/29dhu9A via IFTTT
The electrophysiology of thyroid surgery: electrophysiologic and muscular responses with stimulation of the vagus nerve, recurrent laryngeal nerve, and external branch of the superior laryngeal nerve
Objectives/Hypothesis Correlation of physiologically important electromyographic (EMG) waveforms with demonstrable muscle activation is important for the reliable interpretation of evoked waveforms during intraoperative neural monitoring (IONM) of the vagus nerve, recurrent laryngeal nerve (RLN), and external branch of the superior laryngeal nerve (EBSLN) in thyroid surgery. Study Design Retrospective chart review. Methods Data were reviewed retrospectively for thyroid surgery patients with laryngeal nerve IONM from January to December, 2015. EMG responses to monopolar stimulat... περισσότερα »
Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Background Littoral cell angioma (LCA) is a rare primary splenic tumor frequently associated with internal malignancies. Immunohistochemistry (IHC) can prove a distinct hybrid endothelial/histiocytic phenotype of littoral cells and is a helpful adjunct to render the correct diagnosis. We present a series of 25 LCA with an emphasis on the frequent association of the […]
Subcranial craniofacial resection for advanced sinonasal malignant tumours involving the anterior skull base
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Research Articles C C Yong, A Soni-Jaiswal, J J Homer The Journal of Laryngology & Otology,FirstView Article(s), 6 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29dhu9A via IFTTT
Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Purpose NHS-IL12 is an immunocytokine targeting necrotic tumour areas. IL12 shows anti-tumour activity. As local irradiation might induce additional necrosis in solid tumours, we aimed to evaluate the increase in intratumoural accumulation of NHS-IL12 after irradiation and correlate the findings with diffusion-weighted MRI studies in two xenograft models. Methods Human rhabdomyosarcoma (A204) and prostate […]
Natural History, Risk Factors and Clinical Features of Primary Hypogonadism in Ageing Men: Longitudinal Data from the European Male Ageing Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Objective In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinising hormone (LH) are unclear. We describe the natural history, risk factors and clinical features associated with the development of biochemical primary hypogonadism (PHG, T<10.5nmol/L and LH>9.4U/L) in ageing men. Design, Patients and Measurements A prospective observational cohort […]
Association of thyroid-stimulating hormone with lipid concentrations: an 11-year longitudinal study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Background Scant data exist on the longitudinal association between thyroid function and lipid concentrations. We investigated associations of TSH and lipid concentrations cross-sectionally and longitudinally in a nationwide population sample. Methods 5205 randomly sampled participants representative of Finns aged ≥30 years were examined in 2000–2001 and included in cross-sectional analyses. 2486 were re-examined 11 […]
Subcranial craniofacial resection for advanced sinonasal malignant tumours involving the anterior skull base
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Research Articles C C Yong, A Soni-Jaiswal, J J Homer The Journal of Laryngology & Otology,FirstView Article(s), 6 pages Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29dhu9A via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Purpose NHS-IL12 is an immunocytokine targeting necrotic tumour areas. IL12 shows anti-tumour activity. As local irradiation might induce additional necrosis in solid tumours, we aimed to evaluate the increase in intratumoural accumulation of NHS-IL12 after irradiation and correlate the findings with diffusion-weighted MRI studies in two xenograft models. Methods Human rhabdomyosarcoma (A204) and prostate […]
Natural History, Risk Factors and Clinical Features of Primary Hypogonadism in Ageing Men: Longitudinal Data from the European Male Ageing Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Objective In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinising hormone (LH) are unclear. We describe the natural history, risk factors and clinical features associated with the development of biochemical primary hypogonadism (PHG, T<10.5nmol/L and LH>9.4U/L) in ageing men. Design, Patients and Measurements A prospective observational cohort […]
Association of thyroid-stimulating hormone with lipid concentrations: an 11-year longitudinal study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Background Scant data exist on the longitudinal association between thyroid function and lipid concentrations. We investigated associations of TSH and lipid concentrations cross-sectionally and longitudinally in a nationwide population sample. Methods 5205 randomly sampled participants representative of Finns aged ≥30 years were examined in 2000–2001 and included in cross-sectional analyses. 2486 were re-examined 11 […]
Extended Cost-Effectiveness Analysis for Health Policy Assessment: A Tutorial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Health policy instruments such as the public financing of health technologies (e.g., new drugs, vaccines) entail consequences in multiple domains. Fundamentally, public health policies aim at increasing the uptake of effective and efficient interventions and at subsequently leading to better health benefits (e.g., premature mortality and morbidity averted). In addition, public health policies can […]
Environmental Disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Progress in the studies on hormesis of low-dose pollutants by Junyi Shi via Environmental Disease : 2016 – 1(2) Junyi Shi, Mitchell Huber, Ting Wang, Wang Dali, Zhifen Lin, Yin Chun-Sheng Environmental Disease 2016 1(2):58-64 Hormesis can be defined as a biphasic dose-response relationship characterized by low-dose simulation and high-dose inhibition. Given that environmental pollutants are more often […]
Subcranial craniofacial resection for advanced sinonasal malignant tumours involving the anterior skull base
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 28 δευτερόλεπτα
Research Articles C C Yong, A Soni-Jaiswal, J J HomerThe Journal of Laryngology & Otology,FirstView Article(s), 6 pages Abstract from #ORL via xlomafota13 on Inoreader http://ift.tt/29dhu9A via IFTTT http://ift.tt/29gYi9d
Littoral cell angioma of the spleen: a study of 25 cases with confirmation of frequent association with visceral malignancies
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Abstract Background Littoral cell angioma (LCA) is a rare primary splenic tumor frequently associated with internal malignancies. Immunohistochemistry (IHC) can prove a distinct hybrid endothelial/histiocytic phenotype of littoral cells and is a helpful adjunct to render the correct diagnosis. We present a series of 25 LCA with an emphasis on the frequent association of the neoplasm with visceral malignancies and provide a detailed immunohistochemical analysis by employing new markers. Design All 25 cases with available tissue blocks were immunohistochemically stained for endot... περισσότερα »
HER2-Testung beim Magenkarzinom
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Zusammenfassung Eine valide HER2-Testung ist für die optimale Versorgung von Magenkrebspatienten mit einer HER2-Aktivierung und den richtigen Einsatz einer Erstlinienbehandlung essenziell. Während mittlerweile jedes Mammakarzinom routinemäßig auf den HER2-Status getestet wird, wird die HER2-Testung beim Magenkarzinom noch nicht standardmäßig durchgeführt und erfolgt meist nur auf Anforderung durch den Therapeuten. Eine deutsche interdisziplinäre Expertengruppe hat die Herausforderungen in der HER2-Testung beim Magenkarzinom zum Anlass genommen, um essenzielle Aspekte und Fragestel... περισσότερα »
Paratrachealer Knoten mit Karzinomverdacht
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Zusammenfassung Drei „paratracheale Lymphknoten" eines 20-jährigen Patienten wurden eingesandt, wovon einer Thyreozyteneinschlüsse mit großen und hellen Kernen zeigt, mit Verdacht auf Metastasen eines papillären Schilddrüsenkarzinoms. Die Befundung der gleichzeitig resezierten und nachgereichten Schilddrüse ergab den Befund einer Autoimmunthyreoiditis (AIT) Hashimoto. In Zusammenschau mit dem Strumektomiepräparat konnten die vermeintlichen Lymphknotenmetastasen als hyperplastisches ektopes Strumagewebe (sog. parasitärer Knoten) mit Befunden einer AIT Hashimoto und den hierfür typi... περισσότερα »
Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models: Abstract Purpose NHS-IL12 is an immunocytokine targeting necrotic tumour areas. IL12 shows anti-tumour activity. As local irradiation might induce additional necrosis in solid tumours, we aimed to evaluate the increase in intratumoural accumulation of NHS-IL12 after irradiation and correlate the findings with diffusion-weighted MRI studies in two xenograft models. Methods Human rhabdomyosarcoma (A204) and prostate cancer (PC3) cells were studied in vitro and ... περισσότερα »
Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment: Abstract Background Glucose and glutamine are the two dominant metabolic substrates in cancer cells. In 13C tracer experiments, however, it is necessary to account for all significant input substrates, as some natural (unlabelled) substrate in the medium, often derived from serum, can be metabolised by cells despite not showing signs of net consumption. Results Using [U-13C6]-glucose tracers and measuring extracellular meta... περισσότερα »
Genomic Landscape of poorly Differentiated and Anaplastic Thyroid Carcinoma.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Genomic Landscape of poorly Differentiated and Anaplastic Thyroid Carcinoma.* Endocr Pathol. 2016 Jul 2; Authors: Xu B, Ghossein R Abstract Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are aggressive thyroid tumors associated with a high mortality rate of 38-57 % and almost 100 % respectively. Several recent studies utilizing next generation sequencing techniques have shed lights on the molecular pathogenesis of these tumors, providing evidence to support a stepwise tumoral progression from well-differentiated to poorly differentiated, a... περισσότερα »
The occlusal imaging and analysis system by T-scan III in tinnitus patients.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*The occlusal imaging and analysis system by T-scan III in tinnitus patients.* Biomed J. 2016 Apr;39(2):139-144 Authors: Di Berardino F, Filipponi E, Schiappadori M, Forti S, Zanetti D, Cesarani A Abstract BACKGROUND: Several studies have demonstrated that the prevalence of temporomandibular disorders (TMDs) in tinnitus patients ranges from 7% to 95%, and it is reported in literature that idiopathic tinnitus patients should be referred to a dentist to define whether or not the tinnitus is associated with TMD. However, the possible pathophysiological relation between TMDs and tin... περισσότερα »
Association between the extent of sigmoid sinus dehiscence and an occurrence of pulsatile tinnitus: a retrospective imaging study.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Association between the extent of sigmoid sinus dehiscence and an occurrence of pulsatile tinnitus: a retrospective imaging study.* Clin Radiol. 2016 Jun 29; Authors: Dong C, Zhao P, Liu Z, Xu W, Lv H, Pang S, Wang Z Abstract AIM: To assess the extent of sigmoid sinus dehiscence (SSD) on high-resolution computed tomography venography (HRCTV) or high-resolution computed tomography (HRCT) images in pulsatile tinnitus (PT) and non-PT groups to determine whether there is an association between the extent of SSD and occurrence of PT. MATERIALS AND METHODS: Twenty-eight SSD patients wi... περισσότερα »
The dual role of ROS, antioxidants and autophagy in cancer.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*The dual role of ROS, antioxidants and autophagy in cancer.* Biomed J. 2016 Apr;39(2):89-92 Authors: Walton EL Abstract In this issue of the Biomedical Journal, we highlight a review revealing that the effect of autophagy, reactive oxygen species, and antioxidants in cancer may be a question of timing and context. We also discuss original research showing that the prevalence of cleft lip with or without palate in Taiwan has declined over the past 20 years, and what this might mean in terms of trends in abortion. Finally, we also learn about risk factors for recurrent hospital-ac... περισσότερα »
Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer.* Biomaterials. 2016 Jun 8;103:101-115 Authors: Fan W, Shi W, Zhang W, Jia Y, Zhou Z, Brusnahan SK, Garrison JC Abstract This work continues our efforts to improve the diagnostic and radiotherapeutic effectiveness of nanomedicine platforms by developing approaches to reduce the non-target accumulation of these agents. Herein, we developed multi-block HPMA copolymers with backbones that are susceptible to cleavage by cathepsin S, a protease that is abundantly expressed in tissues... περισσότερα »
Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.* Cancer Immunol Immunother. 2016 Jul 2; Authors: Hoeller C, Michielin O, Ascierto PA, Szabo Z, Blank CU Abstract Several immunomodulatory checkpoint inhibitors have been approved for the treatment of patients with advanced melanoma, including ipilimumab, nivolumab and pembrolizumab. Talimogene laherparepvec is the first oncolytic virus to gain regulatory approval in the USA; it is also approved in Europe. Talimogene laherparepvec expresses granulocyte-macrophage c... περισσότερα »
Imaging of hypoxia in mouse atherosclerotic plaques with (64)Cu-ATSM.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Imaging of hypoxia in mouse atherosclerotic plaques with (64)Cu-ATSM.* Nucl Med Biol. 2016 May 30;43(9):534-542 Authors: Nie X, Randolph GJ, Elvington A, Bandara N, Zheleznyak A, Gropler RJ, Woodard PK, Lapi SE Abstract INTRODUCTION: Cardiovascular disease is the leading cause of death in the United States. The identification of vulnerable plaque at risk of rupture has been a major focus of research. Hypoxia has been identified as a potential factor in the formation of vulnerable plaque, and it is clear that decreased oxygen plays a role in the development of plaque angiogenesis... περισσότερα »
Indoor particulate matter exposure is associated with increased black carbon content in airway macrophages of former smokers with COPD.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Indoor particulate matter exposure is associated with increased black carbon content in airway macrophages of former smokers with COPD.* Environ Res. 2016 Jun 30;150:398-402 Authors: Belli AJ, Bose S, Aggarwal N, DaSilva C, Thapa S, Grammer L, Paulin LM, Hansel NN Abstract INTRODUCTION: Exposure to fine particulate matter (PM2.5) is associated with worse morbidity in individuals with COPD. Inhaled PM is phagocytosed by airway macrophages (AM), and black carbon measured in AM may serve as a biomarker of air pollution exposure. As there is little data on how indoor PM exposure may... περισσότερα »
Elevated levels of triglycerides and vldl-cholesterol provoke activation of nlrp1 inflammasome in endothelial cells.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Elevated levels of triglycerides and vldl-cholesterol provoke activation of nlrp1 inflammasome in endothelial cells.* Int J Cardiol. 2016 Jun 25;220:52-55 Authors: Bleda S, de Haro J, Varela C, Ferruelo A, Acin F Abstract BACKGROUND: Soluble stimuli present in the plasma of patients with peripheral arterial disease (PAD) are capable of directly stimulating intracellular signalling in endothelium. Oxidized-LDL (oxLDL) induces NLRP3 inflammasome activation in macrophages. However, it is not clear how lipid profile affect NLRP1 inflammasome gene expression in endothelial cells. In ... περισσότερα »
Disseminated choroid plexus papillomas in adults: A case series and review of the literature.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Disseminated choroid plexus papillomas in adults: A case series and review of the literature.* J Clin Neurosci. 2016 Jun 29; Authors: Abdulkader MM, Mansour NH, Van Gompel JJ, Bosh GA, Dropcho EJ, Bonnin JM, Cohen-Gadol AA Abstract Choroid plexus papillomas (CPPs) are uncommon, usually intraventricular, low-grade tumors, accounting for less than 1% of all intracranial neoplasms and 2-4% of brain tumors in children. Dissemination of CPPs to multiple levels of the neuraxis has been seldom observed. Thus far, only 26 adult patients have been reported in the English language literat... περισσότερα »
Genomic Landscape of poorly Differentiated and Anaplastic Thyroid Carcinoma.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Genomic Landscape of poorly Differentiated and Anaplastic Thyroid Carcinoma.* Endocr Pathol. 2016 Jul 2; Authors: Xu B, Ghossein R Abstract Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are aggressive thyroid tumors associated with a high mortality rate of 38-57 % and almost 100 % respectively. Several recent studies utilizing next generation sequencing techniques have shed lights on the molecular pathogenesis of these tumors, providing evidence to support a stepwise tumoral progression from well-differentiated to poorly differentiated, a... περισσότερα »
The occlusal imaging and analysis system by T-scan III in tinnitus patients.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*The occlusal imaging and analysis system by T-scan III in tinnitus patients.* Biomed J. 2016 Apr;39(2):139-144 Authors: Di Berardino F, Filipponi E, Schiappadori M, Forti S, Zanetti D, Cesarani A Abstract BACKGROUND: Several studies have demonstrated that the prevalence of temporomandibular disorders (TMDs) in tinnitus patients ranges from 7% to 95%, and it is reported in literature that idiopathic tinnitus patients should be referred to a dentist to define whether or not the tinnitus is associated with TMD. However, the possible pathophysiological relation between TMDs and tin... περισσότερα »
The dual role of ROS, antioxidants and autophagy in cancer.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*The dual role of ROS, antioxidants and autophagy in cancer.* Biomed J. 2016 Apr;39(2):89-92 Authors: Walton EL Abstract In this issue of the Biomedical Journal, we highlight a review revealing that the effect of autophagy, reactive oxygen species, and antioxidants in cancer may be a question of timing and context. We also discuss original research showing that the prevalence of cleft lip with or without palate in Taiwan has declined over the past 20 years, and what this might mean in terms of trends in abortion. Finally, we also learn about risk factors for recurrent hospital-ac... περισσότερα »
Association between the extent of sigmoid sinus dehiscence and an occurrence of pulsatile tinnitus: a retrospective imaging study.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Association between the extent of sigmoid sinus dehiscence and an occurrence of pulsatile tinnitus: a retrospective imaging study.* Clin Radiol. 2016 Jun 29; Authors: Dong C, Zhao P, Liu Z, Xu W, Lv H, Pang S, Wang Z Abstract AIM: To assess the extent of sigmoid sinus dehiscence (SSD) on high-resolution computed tomography venography (HRCTV) or high-resolution computed tomography (HRCT) images in pulsatile tinnitus (PT) and non-PT groups to determine whether there is an association between the extent of SSD and occurrence of PT. MATERIALS AND METHODS: Twenty-eight SSD patients wi... περισσότερα »
Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Cathepsin S-cleavable, multi-block HPMA copolymers for improved SPECT/CT imaging of pancreatic cancer.* Biomaterials. 2016 Jun 8;103:101-115 Authors: Fan W, Shi W, Zhang W, Jia Y, Zhou Z, Brusnahan SK, Garrison JC Abstract This work continues our efforts to improve the diagnostic and radiotherapeutic effectiveness of nanomedicine platforms by developing approaches to reduce the non-target accumulation of these agents. Herein, we developed multi-block HPMA copolymers with backbones that are susceptible to cleavage by cathepsin S, a protease that is abundantly expressed in tissues... περισσότερα »
Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 39 δευτερόλεπτα
*Systematic review of the use of granulocyte-macrophage colony-stimulating factor in patients with advanced melanoma.* Cancer Immunol Immunother. 2016 Jul 2; Authors: Hoeller C, Michielin O, Ascierto PA, Szabo Z, Blank CU Abstract Several immunomodulatory checkpoint inhibitors have been approved for the treatment of patients with advanced melanoma, including ipilimumab, nivolumab and pembrolizumab. Talimogene laherparepvec is the first oncolytic virus to gain regulatory approval in the USA; it is also approved in Europe. Talimogene laherparepvec expresses granulocyte-macrophage c... περισσότερα »
Highly Sensitive and Reproducible Silicon-Based Surface-Enhanced Raman Scattering Sensors for Real Applications
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C6AN01251E, Minireview Houyu Wang, Xiangxu Jiang, Yao He During the past decades, thanks to silicon nanomaterials' outstanding electronic/optical/mechanical properties, large surface-to-volume ratio, abundant surface chemistry, facile tailorability and good compatibility with modern semiconductor industry, different dimensional silicon nanostructures... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29kGzhx via IFTTT
Subcranial craniofacial resection for advanced sinonasal malignant tumours involving the anterior skull base
Research Articles C C Yong, A Soni-Jaiswal, J J Homer The Journal of Laryngology & Otology,FirstView Article(s), 6 pages Abstract [image: Facebook][image: Twitter][image: Mendeley][image: Email][image: More...] from #ORL via xlomafota13 on Inoreader http://ift.tt/29dhu9A via IFTTT
Omental patch reinforced with polypropylene mesh and split-thickness skin grafting: A new procedure to close the "open abdomen".
*Omental patch reinforced with polypropylene mesh and split-thickness skin grafting: A new procedure to close the "open abdomen".* Int J Surg Case Rep. 2016 Jun 23;25:153-155 Authors: Muñoz Muñoz E, Pardo-Aranda F, García-Olivares E, Pontes De Sousa SP, Forcada P, Veloso E Abstract INTRODUCTION: The "open abdomen" expression widely used to define a full-thickness defect of the abdominal wall intentionally made in some situations like abdominal compartment syndrome, has been replaced by a newest one called "laparostomy". The definitive closure of an open abdomen with a giant full ... περισσότερα »
Testicular seminoma metastasis to duodenum. Misdiagnosed as primary duodenal tumor.
*Testicular seminoma metastasis to duodenum. Misdiagnosed as primary duodenal tumor.* Int J Surg Case Rep. 2016 Jun 18;25:149-152 Authors: Al Ani AH, Al Ani HA Abstract INTRODUCTION: Testicular cancer is the most common malignancy in Males aged 15-35 years. Its incidence comprises 0.8% of all Male cancers worldwide, with a mortality rate of 0.1%. Rarely it metastasizes to the retroperitoneum and invades upper gastrointestinal tract (GIT). Complications like intestinal obstruction, hemorrhage, and perforation are usually present. PRESENTATION OF CASE: We report a 30 year-old male,... περισσότερα »
Stoppa approach for intrapelvic damage control and reconstruction of complex acetabular defects with intra-pelvic socket migration: A case report.
*Stoppa approach for intrapelvic damage control and reconstruction of complex acetabular defects with intra-pelvic socket migration: A case report.* Int J Surg Case Rep. 2016 Jun 25;25:143-148 Authors: Murcia-Asensio A, Ferrero-Manzanal F, Lax-Pérez R, Fernández-Fairén M Abstract INTRODUCTION: Failed hip arthroplasty with intrapelvic acetabular migration can be challenging due to the potential damage of intrapelvic structures. PRESENTATION OF THE CASE: We present a case of a 75 year-old lady with failed hip arthroplasty with loosening of implants and intra-pelvic migration of the... περισσότερα »
Psoas muscle abscess simulating acute appendicits: A case report.
*Psoas muscle abscess simulating acute appendicits: A case report.* Int J Surg Case Rep. 2016 Jun 23;25:139-142 Authors: Miller EL, Miller LF, Carvalho JG, Marsillac A, Pires L, Babinski MA, Monteiro M Abstract INTRODUCTION: Psoas abscess is a rare clinical entity with vague symptomatology. We report a psoas abscess that simulated symptoms of acute appendicitis. PRESENTATION OF CASE: A twenty-five year old male presented pain irradiating to the right iliac fossa and lumbar region associated with thigh flexion. Laboratorial exams revealed leukocytosis with a neutrophil shift to th... περισσότερα »
Malignant chondroid syringoma in a West African cancer institute: A case report.
*Malignant chondroid syringoma in a West African cancer institute: A case report.* Int J Surg Case Rep. 2016 Jun 23;25:137-138 Authors: Ka S, Gnangnon F, Diouf D, Dieng MM, Thiam J, Gaye M, Dem A Abstract OBJECTIVE: To report a case of malignant chondroid syringoma, a rare skin tumor at Joliot Curie Cancer Institute in Dakar. RESULTS: We report a case of malignant chondroid syringoma of the deltoid and axilla in a 53year old patient. Malignant chondroid syringoma is an extremely rare tumor of the sweat glands. It is included in myoepithelial tumors of the skin. It has an epithelia... περισσότερα »
Spontaneous breast cancer remission: A case report.
*Spontaneous breast cancer remission: A case report.* Int J Surg Case Rep. 2016 Jun 25;25:132-136 Authors: Ito E, Nakano S, Otsuka M, Mibu A, Karikomi M, Oinuma T, Yamamoto M Abstract INTRODUCTION: Spontaneous breast cancer remission is a rare phenomenon. We report the disappearance from the remaining breast of a new primary carcinoma that had been confirmed through cytology of a pathological specimen, in a case that is strongly suspected to be spontaneous remission. PRESENTATION OF CASE: A 44-year-old woman underwent breast-conserving surgery for a tumor located on the border betw... περισσότερα »
Massive gastrointestinal bleeding in AIDS patients secondary to histoplasma and cytomegalovirus infection.
*Massive gastrointestinal bleeding in AIDS patients secondary to histoplasma and cytomegalovirus infection.* Int J Surg Case Rep. 2016 Jun 29;25:128-131 Authors: Bruno MA, Parodi M, Olmedo I, Picón Molina H, Palencia R, Doniquian A Abstract INTRODUCTION: The Cytomegalovirus (CMV) is a virus that affects the host and remains latent. When cellular immunity is suppressed, the virus is reactivated and can cause an asymptomatic or devastating infection in immunosuppressed patients. On the other hand, Histoplasmosis is typically a respiratory condition. However, in immunosuppressed pat... περισσότερα »
Clinical significance of post-surgical residual tumor burden and radiation therapy in treating patients with lacrimal adenoid cystic carcinoma.
*Clinical significance of post-surgical residual tumor burden and radiation therapy in treating patients with lacrimal adenoid cystic carcinoma.* Oncotarget. 2016 Jun 23; Authors: Noh JM, Lee E, Ahn YC, Oh D, Kim YD, Woo KI, Ko YH, Kim S Abstract Retrospective analyses were done on 19 lacrimal adenoid cystic carcinoma (ACC) patients who underwent curative treatment between 1997 and 2013. Nine patients (47.4%) had T1-2 disease and ten (52.6%) had T4 disease. Surgical procedures were globe-preserving tumor resection in 11 patients (57.9%), incisional biopsy in five (26.3%), and orbi... περισσότερα »
Association of thyroid-stimulating hormone with lipid concentrations: an 11-year longitudinal study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Abstract Background Scant data exist on the longitudinal association between thyroid function and lipid concentrations. We investigated associations of TSH and lipid concentrations cross-sectionally and longitudinally in a nationwide population sample. Methods 5205 randomly sampled participants representative of Finns aged ≥30 years were examined in 2000–2001 and included in cross-sectional analyses. 2486 were re-examined 11 […]
Giant Cell Arteritis: An Atypical Presentation Diagnosed with the Use of MRI Imaging
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Giant cell arteritis (GCA) is the most common primary systemic vasculitis in western countries in individuals over the age of 50. It is typically characterised by the granulomatous involvement of large and medium sized blood vessels branching of the aorta with particular tendencies for involving the extracranial branches of the carotid artery. Generally the diagnosis […]
News From the World of Rabbits
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
In which we look at news from the world of rabbits.
Natural (Mineral, Vegetable, Coconut, Essential) Oils and Contact Dermatitis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Abstract Natural oils include mineral oil with emollient, occlusive, and humectant properties and the plant-derived essential, coconut, and other vegetable oils, composed of triglycerides that microbiota lipases hydrolyze into glycerin, a potent humectant, and fatty acids (FAs) with varying physico-chemical properties. Unsaturated FAs have high linoleic acid used for synthesis of ceramide-I linoleate, a barrier […]
Red flags presented in current low back pain guidelines: a review
Abstract Objective The purpose of this study was to identify and descriptively compare the red flags endorsed in guidelines for the detection of serious pathology in patients presenting with low back pain to primary care. Method We searched databases, the World Wide Web and contacted experts aiming to find the multidisciplinary clinical guideline in low back pain in primary care, and selected the most recent one per country. We extracted data on the number and type of red flags for identifying patients with higher likelihood of serious pathology. Furthermore, we extracted data on ... περισσότερα »
Read essential research from BMC Medicine
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 57 δευτερόλεπτα
[image: BioMed Central – The Open Access Publisher] BMC Medicine Impact Factor: 8.005 Chief Editor: Sabina Alam BMC Medicine Impact Factor: 8.005 Chief Editor: Sabina Alam Submit Manuscript | Editorial Board | Submission Guidelines | Article Alerts Dear Dr Sfakianakis, Below is a selection of recent articles published in *BMC Medicine*, that demonstrate the breadth and quality of our content. We hope you find the articles of interest and will consider submitting your next manuscript to the journal. ------------------------------ Featured Articles FOR... περισσότερα »
Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models
Abstract Purpose NHS-IL12 is an immunocytokine targeting necrotic tumour areas. IL12 shows anti-tumour activity. As local irradiation might induce additional necrosis in solid tumours, we aimed to evaluate the increase in intratumoural accumulation of NHS-IL12 after irradiation and correlate the findings with diffusion-weighted MRI studies in two xenograft models. Methods Human rhabdomyosarcoma (A204) and prostate… Continue reading Enhanced binding of necrosis-targeting immunocytokine NHS-IL12 after local tumour irradiation in murine xenograft models
Natural History, Risk Factors and Clinical Features of Primary Hypogonadism in Ageing Men: Longitudinal Data from the European Male Ageing Study
Abstract Objective In ageing men, the incidence and clinical significance of testosterone (T) decline accompanied by elevated luteinising hormone (LH) are unclear. We describe the natural history, risk factors and clinical features associated with the development of biochemical primary hypogonadism (PHG, T<10.5nmol/L and LH>9.4U/L) in ageing men. Design, Patients and Measurements A prospective observational cohort… Continue reading Natural History, Risk Factors and Clinical Features of Primary Hypogonadism in Ageing Men: Longitudinal Data from the European Male Ageing Study
Association of thyroid-stimulating hormone with lipid concentrations: an 11-year longitudinal study
Abstract Background Scant data exist on the longitudinal association between thyroid function and lipid concentrations. We investigated associations of TSH and lipid concentrations cross-sectionally and longitudinally in a nationwide population sample. Methods 5205 randomly sampled participants representative of Finns aged ≥30 years were examined in 2000–2001 and included in cross-sectional analyses. 2486 were re-examined 11… Continue reading Association of thyroid-stimulating hormone with lipid concentrations: an 11-year longitudinal study
Pattern of adverse drug reactions reported at a tertiary health care teaching hospital of Tripura: a retrospective study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-07-04T04-14-50Z *Source:* International Journal of Basic & Clinical Pharmacology Prithul Bhattacharjee, Lakshman Das, Ranjib Ghosh, Lalromawii, Uttam Kumar Das. Background: ADR monitoring and reporting activity is in its infancy in India. India rates below 1% in pharmacovigilance as against the world rate of 5%. India is the fourth largest producer of pharmaceuticals in the world. So there is an immense need to improve the pharmacovigilance system to protect the Indian population. This study is aimed to identify ADRs and assess their pattern. Methods: The reports of ADRs were r... περισσότερα »
Evaluation of anticonvulsant activity of volatile oil extract of Nigella sativa seeds by chemically induced seizure model in albino rats
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-07-04T04-14-50Z *Source:* International Journal of Basic & Clinical Pharmacology Asmatanzeem Bepari, Parashivamurthy B. M., Shaik Kalimulla Niazi. Background: The current therapeutic treatment of epilepsy with modern antiepileptic drugs is associated with side effects, dose related chronic toxicity, teratogenic effects and approximately 30% of the patients have intractable seizures. Natural products from folk remedies have contributed significantly in the discovery of modern drugs with novel structures and better safety and efficacy profiles. In this regard, one such plant is N... περισσότερα »
Study of biochemical abnormalities in neonatal seizures with special reference to hyponatremia
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
2016-07-04T03-27-13Z *Source:* International Journal of Contemporary Pediatrics Kamatham Madhusudhan, Nadavapalli Srinivasa Suresh, Talakola Ramesh Babu, Jampana venkateswara Rao, Surisetti Bharath Kumar. Background: Biochemical abnormalities are commonly observed in neonates who are admitted in NICU with seizures. In these babies, biochemical abnormalities can be either primary or secondary. Secondary biochemical abnormalities are commonly observed in the presence of other obvious causes of seizures like HIE, meningitis etc. Hyponatremia, hypoglycemia and hypocalcemia are common me... περισσότερα »
Extended Cost-Effectiveness Analysis for Health Policy Assessment: A Tutorial
Abstract Health policy instruments such as the public financing of health technologies (e.g., new drugs, vaccines) entail consequences in multiple domains. Fundamentally, public health policies aim at increasing the uptake of effective and efficient interventions and at subsequently leading to better health benefits (e.g., premature mortality and morbidity averted). In addition, public health policies can provide non-health benefits in addition to the sole well-being of populations and beyond the health sector. For instance, public policies such as social and health insurance prog... περισσότερα »
The GerdQ questionnaire and high resolution manometry support the hypothesis that proton pump inhibitor-responsive oesophageal eosinophilia is a GERD-related phenomenon
Summary Background Little is known about the relationship between proton pump inhibitor-responsive oesophageal eosinophilia (PPI-REE), eosinophilic esophagitis (EoE) and gastro-oesophageal reflux disease (GERD). Aim To compare high resolution manometry features and symptom profiles of patients with EoE, PPI-REE and GERD. Methods Consecutive patients diagnosed with EoE or PPI-REE according to international criteria (presence of at least one typical symptom of oesophageal dysfunction; at least 15 eosinophils per high-power field at mid/proximal oesophagus, persistence or resoluti... περισσότερα »
Extended Cost-Effectiveness Analysis for Health Policy Assessment: A Tutorial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Health policy instruments such as the public financing of health technologies (e.g., new drugs, vaccines) entail consequences in multiple domains. Fundamentally, public health policies aim at increasing the uptake of effective and efficient interventions and at subsequently leading to better health benefits (e.g., premature mortality and morbidity averted). In addition, public health policies can […]
Review article compared over-the-counter nasal dilators
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The narrowest area of the nose is the internal nasal valve and obstruction can cause airflow trouble. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29aLApl via IFTTT
Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Glucose and glutamine are the two dominant metabolic substrates in cancer cells. In 13C tracer experiments, however, it is necessary to account for all significant input substrates, as some natural (unlabelled) substrate in the medium, often derived from serum, can be metabolised by cells despite not showing signs of net consumption. Results Using […]
Review article compared over-the-counter nasal dilators
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The narrowest area of the nose is the internal nasal valve and obstruction can cause airflow trouble. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29aLApl via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Background Glucose and glutamine are the two dominant metabolic substrates in cancer cells. In 13C tracer experiments, however, it is necessary to account for all significant input substrates, as some natural (unlabelled) substrate in the medium, often derived from serum, can be metabolised by cells despite not showing signs of net consumption. Results Using […]
Preface
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29efjPc via IFTTT
Accelerated late quaternary uplift revealed by 10Be exposure dating of marine terraces, Mejillones Peninsula, northern Chile
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 26 June 2016 Source:Quaternary Geochronology Author(s): Ariane Binnie, Tibor J. Dunai, Steven A. Binnie, Pia Victor, Gabriel González, Andreas Bolten The Mejillones Peninsula is thought to have one of the highest rates of tectonic uplift along the active convergent margin of northern Chile. We use exposure age dating from a flight […]
A high-resolution tephrostratigraphy from Quoyloo Meadow, Orkney, Scotland: Implications for the tephrostratigraphy of NW Europe during the Last Glacial-Interglacial Transition
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 18 June 2016 Source:Quaternary Geochronology Author(s): Rhys Gregory Owen Timms, Ian Peter Matthews, Adrian Paul Palmer, Ian Candy, Lawrence Abel Macro- and crypto-tephra layers deposited in European climate archives during the Last Glacial-Interglacial Transition (LGIT ca. 16–8 ka) have become increasingly important as a means to robustly correlate palaeoclimate records, and […]
Resting-state functional MRI distinguishes temporal lobe epilepsy subtypes
[image: cover.gif?v=1&s=8549207be964b69e6c19f76f] Summary Objective We assessed whether presurgical resting state functional magnetic resonance imaging (fMRI) provides information for distinguishing temporal lobe epilepsy (TLE) with mesial temporal sclerosis (TLE-MTS) from TLE without MTS (TLE-noMTS). Methods Thirty-four patients with TLE and 34 sex-/age-matched controls consented to a research imaging protocol. MTS status was confirmed by histologic evaluation of surgical tissue (TLE-MTS = 16; TLE-noMTS = 18). The fractional amplitude of low-frequency fluctuations (fALFFs) in ... περισσότερα »
The SCN8A encephalopathy mutation p.Ile1327Val displays elevated sensitivity to the anticonvulsant phenytoin
[image: cover.gif?v=1&s=8549207be964b69e6c19f76f] Summary Objective *SCN8A* encephalopathy (early infantile epileptic encephalopathy; EIEE13) is caused by gain-of-function mutations resulting in hyperactivity of the voltage-gated sodium channel Nav1.6. The channel is concentrated at the axon initial segment (AIS) and is involved in establishing neuronal excitability. Clinical features of *SCN8A* encephalopathy include seizure onset between 0 and 18 months of age, intellectual disability, and developmental delay. Seizures are often refractory to treatment with standard antiepilep... περισσότερα »
WONOEP appraisal: Molecular and cellular biomarkers for epilepsy
[image: cover.gif?v=1&s=8549207be964b69e6c19f76f] Summary Peripheral biomarkers have myriad potential uses for treatment, prediction, prognostication, and pharmacovigilance in epilepsy. To date, no single peripheral biomarker has demonstrated proven effectiveness, although multiple candidates are in development. In this review, we discuss the major areas of focus including inflammation, blood–brain barrier dysfunction, redox alterations, metabolism, hormones and growth factors. from Neurology via xlomafota13 on Inoreader http://ift.tt/29gKGLp via IFTTT
The first description of how to take a picture from the microscope with an m-phone
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/29HmVLb via IFTTT
Switching enhancer methylation in metastatic melanoma
Abstract Melanoma is a type of malignancy, which is characterized by a high frequency of genome mutations. The mutations carry a telltale signature of transition mutations at dipyrimidine sequences, a consequence of ultraviolet light exposure of the cells that give rise to these tumors. However, as in other cancers, extensive changes to the epigenome are hallmarks of melanoma as well. This article is protected by copyright. All rights reserved. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/29d6xoJ via IFTTT
Re-evaluation of ‘drug-induced’ Erythema Multiforme in medical literature
Abstract More than 20 years ago was proposed a new clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme1. The validity of that classification was later confirmed by the results of a large epidemiology study showing that SJS and TEN affected different populations than EM and were significantly associated with medications, which was not the case for EM majus 2. This article is protected by copyright. All rights reserved. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/29gu894 via IFTTT
Reducing Flightless I expression decreases severity of psoriasis in an imiquimod-induced murine model of psoriasiform dermatitis
Abstract Background Psoriasis is a common chronic skin condition characterised by excessive inflammation and aberrant epidermal proliferation. An actin remodelling protein, Flightless I (Flii), regulates these processes suggesting a possible role in psoriasis. Objective We sought to determine whether benefit in psoriasiform dermatitis might result after modulating *Flii* gene expression or reducing its levels using neutralising antibodies. Methods Biopsies of psoriatic skin lesions from patients was assessed for Flii levels. Psoriasis-like lesions were induced in Flii heterozyg... περισσότερα »
Use of Flexi-Seal to manage early colostomy complications
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Ten-year analyses of the German DRG data about negative pressure wound therapy
Abstract Exact data regarding the clinical role of negative pressure wound therapy (NPWT) for wound care in a specific country are not available. Thus, we analysed the use of NPWT in hospitalised patients in Germany. Detailed lists of all hospitalised cases treated with NPWT in Germany for each of the years from 2005 to 2014 were obtained from the Federal Statistical Office, as well as lists of the 15 most frequent principal and additional diagnoses documented with NPWT in 2014. Within the 10-year time period of the study, the number of cases treated with NPWT increased by 349%, f... περισσότερα »
Vascular assessment of wound healing: a clinical review
Abstract Although macrovascular screening of patients with chronic wounds, particularly in the lower extremities, is accepted as part of clinical practice guidelines, microvascular investigation is less commonly used for a variety of reasons. This can be an issue because most patients with macrovascular disease also develop concomitant microvascular dysfunction. Part of the reason for less comprehensive microvascular screening has been the lack of suitable imaging techniques that can quantify microvascular dysfunction in connection with non-healing chronic wounds. This is changing ... περισσότερα »
Survey of sensitizing components of oxidative hair dyes (retail and professional products) in Germany
Summary Background Components of oxidative hair dyes, such as p-toluylenediamine, are very potent contact sensitizers to which many consumers as well as hairdressers and their clients are commonly exposed. Methods Based on the qualitative composition of both retail and professional haircare products as determined by package labeling (according to INCI), we conducted a survey on the exposure to active components of oxidative hair dyes in Germany. The joint occurrence of components is also discussed. Results Nearly all of the 20 most commonly used substances are potent or very po... περισσότερα »
Die tumorimmunologische Revolution in der Behandlung des fortgeschrittenen Melanoms
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Eingeschränkte Verfügbarkeit diagnostischer Epikutantest-Allergene gefährdet die Patientenversorgung
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Incidence of epithelial proliferations in patients treated with vemurafenib
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Kongresskalender 2016
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