Molecular Targeted Magnetic Resonance Imaging of Human Colorectal Carcinoma (LoVo) Cells Using Novel Superparamagnetic Iron Oxide- Loaded Nanovesicles: In Vitro and in vivo Studies
Objective: To investigate the feasibility of superparamagnetic iron oxide (SPIO) nanoparticles (SPIO) as a magnetic resonance (MR) contrast agent to enhance tumor imaging in vivo. Methods: Hydrophobic SPIO (oil-soluble SPIO; OSPIO) and hydrophilic SPIO (water-soluble SPIO; WSPIO) were loaded in methoxy-poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-PDLLA) nanovesicles. Three groups of nude mice (n=12/group) xenografted with human colorectal carcinoma (LoVo) cells were injected into the caudal vein with WSPIO, OSPIO-loaded nanovesicles, or WSPIO-loaded nanovesicles. MRI sc... περισσότερα »
Tissue Oximetry and Clinical Outcomes.
A number of different technologies have been developed to measure tissue oxygenation, with the goal of identifying tissue hypoxia and guiding therapy to prevent patient harm. In specific cases, tissue oximetry may provide clear indications of decreases in tissue oxygenation such as that occurring during acute brain ischemia. However, the causation between tissue hemoglobin-oxygen desaturation in one organ (e.g., brain or muscle) and global outcomes such as mortality, intensive care unit length of stay, and remote organ dysfunction remains more speculative. In this review, we describ... περισσότερα »
The Use of Ultrasound Guidance for Perioperative Neuraxial and Peripheral Nerve Blocks in Children: A Cochrane Review.
BACKGROUND: Objectives were to determine whether the use of ultrasound guidance offers any clinical advantage in the performance of neuraxial or peripheral nerve blocks in children in terms of increasing the success rate or decreasing the rate of complications. METHODS: We searched the following databases to March 2015: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (OvidSP), EMBASE (OvidSP), and Scopus (to January 2015). We included all parallel randomized controlled trials that evaluated the effect of ultrasound guidance to perform a regional blockade technique i... περισσότερα »
Effect of Individual Surgeons and Anesthesiologists on Operating Room Time.
BACKGROUND: Variability in operating room (OR) time causes overutilization and underutilization of the available ORs. There is evidence that for a given type of procedure, the surgeon is the major source of variability in OR time. The primary aim was to quantify the variability between surgeons and anesthesiologists. As illustration, the value of modeling the individual surgeons and anesthesiologist for OR time prediction was estimated. METHODS: OR data containing 16,480 cases were obtained from a general surgery department. The total amount of variability in OR time accounted for b... περισσότερα »
Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review.
Volatile anesthetics (VAs) have been in clinical use for a very long time. Their mechanism of action is yet to be fully delineated, but multiple ion channels have been reported as targets for VAs (canonical VA targets). It is increasingly recognized that VAs also manifest effects outside the central nervous system, including on immune cells. However, the literature related to how VAs affect the behavior of immune cells is very limited, but it is of interest that some canonical VA targets are reportedly expressed in immune cells. Here, we review the current literature and describe ca... περισσότερα »
Factors Influencing the Choice of Anesthesia as a Career by Undergraduates of the University of Rwanda.
BACKGROUND: Rwanda currently faces a severe shortage of trained medical personnel, including physician anesthesiologists. The recruitment of residents into the anesthesia program has been consistently low. This study aimed at determining the factors that influence undergraduates' decision to pursue anesthesia as a career choice. METHODS: A questionnaire was created and administered to final year undergraduate medical students at the University of Rwanda. The questionnaire was created based on factors identified from literature review and key informant interviews. The questionnaire w... περισσότερα »
The effect of a flapless alveolar ridge preservation procedure with or without a xenograft on buccal bone crest remodeling compared by histomorphometric and microcomputed tomographic analysis
Abstract Objectives This study evaluated buccal bone crest remodeling, socket composition after healing, and dimensional ridge preservation after flapless tooth extraction procedures with or without a xenograft comparing histomorphometric and microcomputed tomographic (micro-CT) data. Material and Methods The mandibular premolars of eight dogs were extracted without flaps. One socket on each side received a grafting material (test group), and the other remained only with a blood clot (control group). Twelve weeks after treatment, buccal bone crest, alveolar ridge dimensions, and com... περισσότερα »
The Evolution of TMD Diagnosis: Past, Present, Future
This review explores the principles and process associated with the diagnosis of temporomandibular disorders (TMDs). TMD diagnosis has evolved substantially over the past 25 y. Previously, diagnosis focused solely on aberrations in oral structures, largely without empirical evidence. The Research Diagnostic Criteria for TMD (RDC/TMD) were developed on core principles of 1) a dual-axis system reflecting the biopsychosocial model, 2) a clear operationalization for reliability, and 3) the allowance of multiple diagnoses. These principles were retained in the subsequent validation res... περισσότερα »
The Impact of Surgery and Stored Red Blood Cell Transfusions on Nitric Oxide Homeostasis.
BACKGROUND: Cell-free hemoglobin (Hb) forms in stored red blood cells (RBCs) as a result of hemolysis. Studies suggest that this cell-free Hb may decrease nitric oxide (NO) bioavailability, potentially leading to endothelial dysfunction, vascular injury, and multiorgan dysfunction after transfusion. We tested the hypothesis that moderate doses of stored RBC transfusions increase cell-free Hb and decrease NO availability in postoperative surgical patients. METHODS: Twenty-six patients undergoing multilevel spine fusion surgery were studied. We compared those who received no stored RB... περισσότερα »
The Impact of Electrode Array Length on Hearing Preservation in Cochlear Implantation.
Objective: The aim of the study was to determine the degree of hearing preservation (HP) and its relation to electrode array length after cochlear implantation using different thin flexible electrode arrays (TFEA). Study Design: Retrospective analysis. Intervention: One hundred twenty adult patients with preoperative residual hearing received a cochlear implant with a TFEA: 46 received a TFEA20, 34 a TFEA24, and 40 a TFEA28 mm. Main Outcome Measures: Pure-tone audiometry (125-1500 Hz) was performed preoperatively, at initial fitting, and at 3, 6, and 12 months postoperatively. Media... περισσότερα »
Stapedotomy With Adipose Tissue Seal: Hearing Outcomes, Incidence of Sensorineural Hearing Loss, and Comparison to Alternative Techniques.
Objective: To evaluate hearing outcomes and incidence of sensorineural hearing loss (SNHL) after stapedotomy with adipose tissue seal, and to compare adipose tissue sealing with alternative techniques. Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: Primary stapedotomy was performed in 179 patients using a KTP laser, microdrill, piston prosthesis, and adipose tissue seal of the oval window fenestra between 1991 and 2015. An additional 123 patients underwent stapes surgery with alternative techniques. Interventions: Stapes surgery for otoscleros... περισσότερα »
Temporal Lobe Gliosarcoma After Gamma Knife Radiosurgery for Vestibular Schwannoma.
Objective: Secondary tumorigenesis after exposure to ionizing radiation is a well-described phenomenon. The probability of developing a malignancy after stereotactic radiosurgery (SRS) is theoretically less than conventional external beam radiation therapy; however, the exact risk remains unknown. Such information is important for patient counseling when considering treatment of benign conditions such as vestibular schwannoma (VS). The objective of the current report is to describe a case of a temporal lobe gliosarcoma developing 3 years after radiosurgical treatment of a sporadic V... περισσότερα »
The electrode in a cochlear implant (CI) system
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Optimal electrode design: Straight versus perimodiolar via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): P. Gibson, P. BoydThe electrode in a cochlear implant (CI) system is a key factor in hearing performance as it is the interface between the device and the auditory pathway of the recipient. […]
Electrode-design.Electric compound action potentials (ECAPs)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
ECAP analysis in cochlear implant patients as a function of patient’s age and electrode-design via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): F. Christov, P. Munder, L. Berg, H. Bagus, S. Lang, D. Arweiler-HarbeckIntroductionElectric compound action potentials (ECAPs) provide information about the […]
Unilateral submandibular depression
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Unilateral submandibular depression via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): R. Bhoil, K.A. Mistry, R. Bhoil, K. Thakur http://ift.tt/1UcyLvR
On the long term the lexical level remains a relevant tool to assess the evolution of implantees.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Long term results after cochlear implantation: Schooling and social insertion of teenagers and young adults via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): M. Blanchard, C. Célerier, M. Parodi, D. Sabban, I. Prang, I. Rouillon, B. Frachet, N. LoundonIntroductionTo analyse the long-term impact of cochlear implantation (CI) […]
Paediatric and adult cochlear implantation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
Cochlear implants in Belgium: Prevalence in via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): L. De RaeveObjectivesBelgium, and especially the northern region called Flanders, has been a centre of expertise in cochlear implants and early hearing screening for many years. Cochlear implants are reimbursed by the Belgian […]
Mid-scala electrode array
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 25 δευτερόλεπτα
The rational for a via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): P.J. BoyleToday increasing numbers of cochlear implant candidates have residual hearing that can be aided and hence is worth trying to preserve. This means that surgical technique and electrode array design must be adapted to […]
A possible carbon monoxide shuttle in the lung
The Coburn, Forster, Kane Equation (CFKE) describes a current understanding of the physiology of lung uptake and excretion of carbon monoxide (CO). The lung mean capillary PCO is an important term in this equation because it drives CO excretion and functions as "back-pressure" during uptake of exogenous CO. Results of previous studies have indicated that the mean capillary PCO of normal human lungs is equal to values calculated using the Haldane Equation, as described by the CFKE. The physiological explanation of how this parameter is set at this level is unknown. As a possible ex... περισσότερα »
Qualitative dimensions of exertional dyspnea in adults with cystic fibrosis
No studies in cystic fibrosis (CF) have systematically characterized the evolution of the qualitative dimensions of exertional dyspnea. Adults with CF (n=25) and sex-, age-, and body mass index-matched controls (n=25) underwent cardiopulmonary cycle exercise testing with a detailed evaluation of ventilatory and dyspnea responses. The qualitative dimensions of dyspnea were examined during each exercise stage by having subjects select phrases that best described their breathing (i.e., "work/effort", "unsatisfied inspiration", and "unsatisfied expiration"). Subjects also selected phra... περισσότερα »
Differential effects of respiratory and electrical stimulation-induced dilator muscle contraction on mechanical properties of the pharynx in the pig.
Introduction: Respiratory stimulation (RS) during sleep often fails to discontinue flow limitation, while electrical stimulation (ES) of the hypoglossus (HG) nerve frequently prevents obstruction. The present work compares the effects of RS and HG-ES on pharyngeal mechanics, as well as the relative contribution of tongue muscles and thoracic forces to pharyngeal patency. Methods: We determined the pressure-area relationship of the collapsible segment of the pharynx in anesthetized pigs under 3 conditions: baseline (BL), RS induced by partial obstruction of the tracheostomy tube, a... περισσότερα »
Cardiovascular control during whole body exercise
It has been considered whether during whole body exercise the increase in cardiac output is large enough to support skeletal muscle blood flow. This review addresses four lines of evidence for a flow limitation to skeletal muscles during whole body exercise. First, even though during exercise the blood flow achieved by the arms is lower than that achieved by the legs (~160 vs. ~385 ml/min/100 g) the muscle mass that can be perfused with such flow is limited by the capacity to increase cardiac output (42 l/min, highest recorded value). Secondly, activation of the exercise pressor r... περισσότερα »
Music-based training for pediatric CI recipients
: A systematic analysis of published studies via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): K. Gfeller In recent years, there has been growing interest in the use of music-based training to enhance speech and language development in children with normal hearing and some forms of communication disorders, including pediatric CI users. The use of music training for CI users may initially seem incongruous given that signal processing for CIs presents a degraded version of pitch and timb... περισσότερα »
The cochlear duct length (CDL),Electrode length
Optimal electrode length to match patient specific cochlear anatomy via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): P. Mistrík, C. Jolly Cochlear implantation (CI) has reached over years of practicing high standards of surgical outcomes. Even patients with significant residual hearing are nowadays benefiting from a cochlear implant. However, the speech perception still depends to great extent on the adequate pitch match between the frequency components delivered by an electrode array ... περισσότερα »
CSF Gusher in Cochlear Implant Surgery
–does it affect surgical outcomes? via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): S. Vashist, S. Singh ObjectivesThe purpose of this prospective study was to measure surgical outcomes in cases of cerebrospinal fluid gusher in cochlear implant surgery.Materials and methodsDemographic, radiological, neurophysiological and surgical results were evaluated in nine cases of patients with cerebrospinal fluid gusher during cochlear implant surgery, out of 164 unilateral cochlear implant pro... περισσότερα »
The electrode in a cochlear implant (CI) system
Optimal electrode design: Straight versus perimodiolar via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): P. Gibson, P. Boyd The electrode in a cochlear implant (CI) system is a key factor in hearing performance as it is the interface between the device and the auditory pathway of the recipient. The first CI electrodes were straight and thus adopted a lateral wall position. Subsequent innovations include: perimodiolar electrodes designed to lie adjacent to the modiolar wall and thus to ... περισσότερα »
Electrode-design.Electric compound action potentials (ECAPs)
ECAP analysis in cochlear implant patients as a function of patient's age and electrode-design via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): F. Christov, P. Munder, L. Berg, H. Bagus, S. Lang, D. Arweiler-Harbeck IntroductionElectric compound action potentials (ECAPs) provide information about the nerve's and device's function in and after cochlear implantation. In general, lower ECAP values are expected to generate better results. Aim wa... περισσότερα »
Unilateral submandibular depression
Unilateral submandibular depression via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): R. Bhoil, K.A. Mistry, R. Bhoil, K. Thakur [image: a: ultrasound of the neck right submandibular gland; b: ultrasound neck ...]
On the long term the lexical level remains a relevant tool to assess the evolution of implantees.
Long term results after cochlear implantation: Schooling and social insertion of teenagers and young adults via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): M. Blanchard, C. Célerier, M. Parodi, D. Sabban, I. Prang, I. Rouillon, B. Frachet, N. Loundon IntroductionTo analyse the long-term impact of cochlear implantation (CI) in deaf patients on perception and language, and on schooling and social insertion.MethodA total of 131 profoundly deaf patients that had unilateral CI, aged at fo... περισσότερα »
A Longitudinal Study of Symptoms of Oropharyngeal Dysphagia in an Elderly Community-Dwelling Population
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Abstract Dysphagia has been estimated to affect around 8–16 % of healthy elderly individuals living in the community. The present study investigated the stability of perceived dysphagia symptoms over a 3-year period and whether such symptoms predicted death outcomes. A population of 800 and 550 elderly community-dwelling individuals were sent the Sydney Swallow Questionnaire (SSQ) […]
Series Transgender people: health at the margins of society
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
In this paper we examine the social and legal conditions in which many transgender people (often called trans people) live, and the medical perspectives that frame the provision of health care for transgender people across much of the world. Modern research shows much higher numbers of transgender people than were apparent in earlier clinic-based studies, […]
Series Global health burden and needs of transgender populations: a review
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Transgender people are a diverse population affected by a range of negative health indicators across high-income, middle-income, and low-income settings. Studies consistently document a high prevalence of adverse health outcomes in this population, including HIV and other sexually transmitted infections, mental health distress, and substance use and abuse. However, many other health areas remain understudied, […]
Perspectives Transgender: why should we care?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
It was entirely coincidence that I changed employment in 1988 as I was awaiting confirmation from the doctors at Stanford University that I was a worthy candidate for sex reassignment. I had researched and soul-searched for years, struggling with the decision to apply to that programme. I had learned that their entrance criteria were rigorous, […]
Perspectives Sam Winter and Kevan Wylie: pioneers in transgender health
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Sam Winter clearly recalls the first time he became aware of the health needs of transgender people. “When working in Hong Kong I met a young person who had recently self-identified as a trans girl. She had been thrown out of the family home by her parents, and could not find a job because of […]
Copyright Page
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Publication date: July 2016 Source:Radiologic Clinics of North America, Volume 54, Issue 4 from Radiology via xlomafota13 on Inoreader http://ift.tt/1Uz1qyM via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28JnBsc via IFTTT
Optimised room temperature, water-based synthesis of CPO-27-M metal-organic frameworks with high space-time yields
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Journal of materials chemistry. A, Materials for energy and sustainability from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YwlDXk via IFTTT
Index
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Publication date: May 2016 Source:Radiologic Clinics of North America, Volume 54, Issue 3 from Radiology via xlomafota13 on Inoreader http://ift.tt/1Px4jua via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UcwK2G via IFTTT
Cryo-focused Ion Beam Sample Preparation for Imaging Vitreous Cells by Cryo-electron Tomography
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Bio-protocol from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/23fvKk8 via IFTTT
Decreased Expression of miR-548c-3p in Osteosarcoma Contributes to Cell Proliferation Via Targeting ITGAV
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 43 δευτερόλεπτα
Cancer Biotherapy & Radiopharmaceuticals Jun 2016, Vol. 31, No. 5: 153-158. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/28J5tyy via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/28JpMvK via IFTTT
Implementation of Clinical Pharmacogenomics within a Large Health System: From Electronic Health Record Decision Support to Consultation Services
[image: cover.gif?v=1&s=12b7a98c604d4bdaa6585371] Abstract The number of clinically relevant, gene-based guidelines and recommendations pertaining to drug prescribing continues to grow. Incorporating gene-drug interaction information into the drug prescribing process can help optimize pharmacotherapy outcomes and improve patient safety. However, pharmacogenomic implementation barriers exist such as integration of pharmacogenomic results into electronic health records (EHRs), development and deployment of pharmacogenomic decision-support tools to EHRs, and feasible models for esta... περισσότερα »
Safety profile of biologic drugs in the therapy of ulcerative colitis: a systematic review and network meta-analysis
Abstract Objectives Compare the safety profile of biologic drugs in patients with moderately to severe active ulcerative colitis (UC). Methods A systematic literature search was performed using Medline (PubMed), Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) databases through February 9, 2016. We included randomized controlled trials (RCTs) that compared the safety of biologic drugs (infliximab, adalimumab, golimumab, and vedolizumab) with one another or with placebo in patients with UC. Two reviewers independently conducted the search and selection of stud... περισσότερα »
Cochlear implantation in children with congenital unilateral deafness
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
: Mid-term follow-up outcomes via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): D. Távora-Vieira, G.P. RajanObjectivesAlthough cochlear implantation is widely used to treat unilateral deafness in adults, very little literature exists on its use and effects on the paediatric population. This report adds to the literature showing […]
The performance of the sequentially implanted ear depends to an extent on a negative influence, which could be considered as a type of inhibition, of the first implanted ear over the second ear.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Active inhibition of the first over the second ear implanted sequentially via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): S. Burdo, A. Giuliani, L. Dalla CostaObjectiveTo identify the influence of the first implanted ear on the performance of the delayed sequentially implanted […]
Children using hearing aids or cochlear implants
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Hearing-related quality of life outcomes for Singaporean via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): V. Looi, Z.Z. Lee, J.H.Y. LooObjectivesThe Children Using Hearing Devices Quality of Life Questionnaire (CuHDQOL) is a new parent-administered hearing-specific questionnaire for children fitted with hearing devices. […]
Children with asymmetric hearing loss (AHL),Children with single side deafness (SSD condition)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
AHL, SSD and bimodal CI results in children via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): Á. Ramos Macías, S.A. Borkoski-Barreiro, J.C. Falcón González, Á. Ramos de MiguelObjectiveThis article aims to demonstrate that children with asymmetric hearing loss (AHL), specifically those with single side deafness (SSD condition) […]
Serum calcium, albumin and tumor stage in cutaneous malignant melanoma
Future Oncology Ahead of Print. from Melanoma via xlomafota13 on Inoreader http://ift.tt/1ZVadv2
Optimized magnitude of cryosurgery facilitating anti-tumor immunoreaction in a mouse model of Lewis lung cancer
AbstractBackground Cryosurgery has reemerged as a less invasive local treatment with possible immune-regulatory effects. However, the optimal magnitude of cryosurgery for achieving immune-regulatory responses at abscopal tumor sites remains unclear. We aimed to investigate appropriate magnitude of cryosurgery for this goal using a mouse model. Methods C57BL/6J mice were inoculated with Lewis lung carcinoma cells or B16 melanoma cells in bilateral flanks. The left-sided tumor was cryoablated with repeated freeze/thaw cycles either once, twice, or thrice. The peritumoral injections o... περισσότερα »
Long non-coding RNA ROR promotes proliferation, migration and chemoresistance of nasopharyngeal carcinoma
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Nasopharyngeal carcinoma (NPC) is one of the most common malignancies of the head and neck. It arises from the nasopharynx epithelium with high morbidity and mortality. Long non-coding RNAs (lncRNAs) have been reported to regulate gene interaction and play critical roles in carcinogenesis and progression. LncRNA-ROR, a recently identified lncRNA, has been shown to […]
Withaferin A suppresses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Summary Treatment outcomes for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) remain unsatisfactory despite progress in various types of chemotherapy and hematopoietic stem cell transplantation. Therefore, there is a need for the development of new treatment options. We investigated the growth-suppressive effects of withaferin A (WA), a natural plant steroidal lactone, on myelodysplasia and […]
Australia antibiotic alert: Deadly superbug that can destroy heart valves spreading fast due to antibiotic overuse – International Business Times AU
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
International Business Times AU Australia antibiotic alert: Deadly superbug that can destroy heart valves spreading fast due to antibiotic overuse International Business Times AU The report also found that people suffering from acute bronchitis, middle ear infections, sinusitis and tonsillitis were given antibiotics. Moreover, patients were also given wrong antibiotics for wrong durations. Repeat prescriptions […]
Vitiligo
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Vitiligo: A condition in which the skin turns white due to the loss of pigment from the melanocytes, cells that produce the pigment melanin that gives the skin color. In vitiligo, the melanocytes are destroyed, leaving depigmented patches of skin. The hair that grows in areas affected by vitiligo may also turn white. The skin […]
Biomechanical factors associated with the development of tibiofemoral knee osteoarthritis: protocol for a systematic review and meta-analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Introduction Altered biomechanics, increased joint loading and tissue damage, might be related in a vicious cycle within the development of knee osteoarthritis (KOA). We have defined biomechanical factors as joint-related factors that interact with the forces, moments and kinematics in and around a synovial joint. Although a number of studies and systematic reviews have been […]
Medical consumption compared for TIMI and HEART score in chest pain patients at the emergency department: a retrospective cost analysis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objective To investigate which risk score (TIMI score or HEART score) identifies the largest population of low-risk patients at the emergency department (ED). Furthermore, we retrospectively calculated the corresponding expected decrease in medical consumption if these patients would have been discharged from the ED. Methods We performed analyses in two hospitals of the multicentre prospective […]
Tai Chi for stroke rehabilitation: protocol for a systematic review
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Introduction Stroke is a major cause of death and disability, and imposes a huge burden and significant workload for patients, their families and society. As a special form of physical activity, Tai Chi is may be useful for stroke rehabilitation. The objective of this review is to systematically evaluate the efficacy and safety of Tai […]
Effectiveness of a pharmacist-led educational intervention to reduce the use of high-risk abbreviations in an acute care setting in Saudi Arabia: a quasi-experimental study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives To evaluate the effectiveness of a pharmacist-led educational intervention to reduce the use of high-risk abbreviations (HRAs) by healthcare professionals. Design Quasi-experimental study consisting of a single group before-and-after study design. Setting A public emergency hospital in Mecca, Saudi Arabia. Participants 660 (preintervention) and then 498 (postintervention) handwritten physician orders, medication administration records (MRAs) […]
Implementing referral to an electronic alcohol brief advice website in primary healthcare: results from the ODHIN implementation trial
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives The objective of the present study was to explore whether the possibility of offering facilitated access to an alcohol electronic brief intervention (eBI) instead of delivering brief face-to-face advice increased the proportion of consulting adults who were screened and given brief advice. Design The study was a 12-week implementation study. Sixty primary healthcare units […]
Assessment of Computer Literacy of Nurses in Lesotho.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Health systems worldwide are moving toward use of information technology to improve healthcare delivery. However, this requires basic computer skills. This study assessed the computer literacy of nurses in Lesotho using a cross-sectional quantitative approach. A structured questionnaire with 32 standardized computer skills was distributed to 290 randomly selected nurses in Maseru District. Univariate and […]
Gardner’s syndrome associated with a fibromatous tumour of the parotid
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Gardner’s syndrome presenting with a fibromatous tumour of the parotid via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): N. Guignard, C. Cartier, L. Crampette, M. AkkariIntroductionGardner’s syndrome is the association of familial adenomatous polyposis (FAP) with an anaphase promoting complex (APC) gene […]
Children with autism spectrum disorder (ASD) : Receptive speech in early implanted children
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
later diagnosed with autism via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): B. Mikic, A. Jotic, D. Miric, M. Nikolic, N. Jankovic, N. ArsovicIntroductionIncidence of children with autism spectrum disorder (ASD) is rising through the years with estimated 1 in 68 in the US in 2014. This […]
Two tumour staging classifications in patients with sinonasal mucosal melanoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Prognostic value of via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): A. Houette, L. Gilain, A. Mulliez, T. Mom, N. SaroulIntroductionSinonasal mucosal melanoma is a rare disease associated with a very poor prognosis. The purpose of this study was to assess the […]
Salivary gland-sparing helical tomotherapy for head and neck cancer
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
: Preserved salivary function on quantitative salivary gland scintigraphy after tomotherapy via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 10 June 2016Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): S. Kreps, O. Berges, L. Belin, S. Zefkili, S. Petras, P. GiraudGoalsProspective evaluation of salivary gland preservation, overall survival and local recurrence-free […]
Carotid body paraganglioma resection
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Neurovascular complications following carotid body paraganglioma resection via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): E. Lamblin, I. Atallah, E. Reyt, S. Schmerber, J.-L. Magne, C.A. RighiniObjectiveThe present consecutive case series reports our experience in the management of carotid body paraganglioma and […]
The posterior wall of the sinus can be resected to perform frontal sinus cranialization, allowing access to the midline anterior cranial fossa. The posterior wall of the sinus is removed with a high-speed burr in the same way as the anterior wall. At the end of the procedure, the bone flap is sutured with nylon suture material and the pericranium is sutured over the bone flap.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Optimal enlargement of the frontal sinus approach via European Annals of Otorhinolaryngology, Head and Neck Diseases Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): C.A. Righini, I. Atallah, E. ReytAfter recalling the main anatomical characteristics of the frontal sinuses, the authors describe the frontal craniotomy surgical procedure and its variants. A bicoronal skin incision is performed. […]
Vestibular evaluation in sequentially implanted children
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Interest of vestibular evaluation in sequentially implanted children: Preliminary results via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 30 May 2016Source:European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): B. Devroede, I. Pauwels, S.-D. Le Bon, J. Monstrey, A.-L. MansbachIntroductionAn early acquired or congenital absence of sensory input of the vestibule will […]
The vascular strip is an uncommon source of iatrogenic cholesteatoma that can present years following an otherwise uncomplicated otologic surgery. The findings presented herein highlight the importance of careful vascular strip orientation at the conclusion of otologic surgery.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Iatrogenic cholesteatoma arising from the vascular strip: Objectives/Hypothesis To highlight the phenomenon of cholesteatoma arising from the vascular strip following tympanoplasty and tympanomastoidectomy. Study Design Multi-institutional retrospective chart review. Methods Consecutive adult and pediatric patients evaluated between 2000 and 2015 with acquired cholesteatoma arising from the skin of a prior vascular strip were identified. Patients […]
Iatrogenic cholesteatoma arising from the vascular strip
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Iatrogenic cholesteatoma arising from the vascular strip: Objectives/Hypothesis To highlight the phenomenon of cholesteatoma arising from the vascular strip following tympanoplasty and tympanomastoidectomy. Study Design Multi-institutional retrospective chart review. Methods Consecutive adult and pediatric patients evaluated between 2000 and 2015 with acquired cholesteatoma arising from the skin of a prior vascular strip were identified. Patients […]
Caloric and head-impulse tests during the attacks of Meniere’s disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Comparison of Objectives/Hypothesis To aid in diagnosis of Meniere’s disease (MD) during the attacks using caloric and head-impulse tests (HITs). Study Design Retrospective case series review. Methods We analyzed the results of bithermal caloric and HITs during the attacks in 16 patients with MD. Quantitative analyses of HITs were conducted using a magnetic search coil […]
Effect of external PEEP in patients under controlled mechanical ventilation with an auto-PEEP of 5 cmH2O or higher
In some patients with auto-positive end-expiratory pressure (auto-PEEP), application of PEEP lower than auto-PEEP maintains a constant total PEEP, therefore reducing the inspiratory threshold load without detr... from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UZg6ms via IFTTT
Paediatric and adult cochlear implantation
Cochlear implants in Belgium: Prevalence in via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): L. De Raeve ObjectivesBelgium, and especially the northern region called Flanders, has been a centre of expertise in cochlear implants and early hearing screening for many years. Cochlear implants are reimbursed by the Belgian National Institute for Health and Disability (BNIHD) Insurance in adults and in children since October 1994. More than 20 years later, we would like to measure the prev... περισσότερα »
Mid-scala electrode array
The rational for a via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): P.J. Boyle Today increasing numbers of cochlear implant candidates have residual hearing that can be aided and hence is worth trying to preserve. This means that surgical technique and electrode array design must be adapted to minimize trauma. Wide opening of the round window is often preferred to reduce drill related trauma and to avoid pressure spikes during electrode array insertion. A recent meta-analysis suggest... περισσότερα »
Cochlear implantation in children with congenital unilateral deafness
: Mid-term follow-up outcomes via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D. Távora-Vieira, G.P. Rajan ObjectivesAlthough cochlear implantation is widely used to treat unilateral deafness in adults, very little literature exists on its use and effects on the paediatric population. This report adds to the literature showing the mid-term follow-up outcomes achieved by these children.Material and methodsThree children with congenital unilateral deafness were studied after implantati... περισσότερα »
The performance of the sequentially implanted ear depends to an extent on a negative influence, which could be considered as a type of inhibition, of the first implanted ear over the second ear.
Active inhibition of the first over the second ear implanted sequentially via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): S. Burdo, A. Giuliani, L. Dalla Costa ObjectiveTo identify the influence of the first implanted ear on the performance of the delayed sequentially implanted ear in pediatric patients.Study designRetrospective case series review.SettingOutpatient Cochlear Implant (CI) center.PatientsCongenitally deaf children who underwent... περισσότερα »
Children using hearing aids or cochlear implants
Hearing-related quality of life outcomes for Singaporean via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): V. Looi, Z.Z. Lee, J.H.Y. Loo ObjectivesThe Children Using Hearing Devices Quality of Life Questionnaire (CuHDQOL) is a new parent-administered hearing-specific questionnaire for children fitted with hearing devices. The aim of this study was to assess outcomes for hearing-impaired children in Singapore using this measure, as well as to ... περισσότερα »
Children with asymmetric hearing loss (AHL),Children with single side deafness (SSD condition)
AHL, SSD and bimodal CI results in children via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Á. Ramos Macías, S.A. Borkoski-Barreiro, J.C. Falcón González, Á. Ramos de Miguel ObjectiveThis article aims to demonstrate that children with asymmetric hearing loss (AHL), specifically those with single side deafness (SSD condition) and pure SSD, with substantial hearing (>70% normal speech discrimination) in the ear with hearing aid (HA), obtain clinically relevant speech perception benefit... περισσότερα »
Gardner's syndrome associated with a fibromatous tumour of the parotid
Gardner's syndrome presenting with a fibromatous tumour of the parotid via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): N. Guignard, C. Cartier, L. Crampette, M. Akkari IntroductionGardner's syndrome is the association of familial adenomatous polyposis (FAP) with an anaphase promoting complex (APC) gene mutation and several extradigestive manifestations: osteomas, epidermal cysts and desmoid tumours. Only 2 cases of FAP associated with parotid... περισσότερα »
Children with autism spectrum disorder (ASD) : Receptive speech in early implanted children
later diagnosed with autism via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): B. Mikic, A. Jotic, D. Miric, M. Nikolic, N. Jankovic, N. Arsovic IntroductionIncidence of children with autism spectrum disorder (ASD) is rising through the years with estimated 1 in 68 in the US in 2014. This incidence is also rising in the population of congenitally deaf children. Favorable outcome after early cochlear implantation is expected due to plasticity and reorganization capacity of brain in infan... περισσότερα »
Two tumour staging classifications in patients with sinonasal mucosal melanoma
Prognostic value of via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): A. Houette, L. Gilain, A. Mulliez, T. Mom, N. Saroul IntroductionSinonasal mucosal melanoma is a rare disease associated with a very poor prognosis. The purpose of this study was to assess the prognostic value of the 2 staging systems published in the literature for these tumours: the American Joint Committee on Cancer (AJCC) Cancer Staging Manual for mucosal melanoma of th... περισσότερα »
Salivary gland-sparing helical tomotherapy for head and neck cancer
: Preserved salivary function on quantitative salivary gland scintigraphy after tomotherapy via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 10 June 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): S. Kreps, O. Berges, L. Belin, S. Zefkili, S. Petras, P. Giraud GoalsProspective evaluation of salivary gland preservation, overall survival and local recurrence-free survival after head and neck cancer treated by helical tomotherapy (HT).Material and methodsFrom March 2007 to February 2009, 30 patien... περισσότερα »
Carotid body paraganglioma resection
Neurovascular complications following carotid body paraganglioma resection via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online June 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): E. Lamblin, I. Atallah, E. Reyt, S. Schmerber, J.-L. Magne, C.A. Righini ObjectiveThe present consecutive case series reports our experience in the management of carotid body paraganglioma and aims to assess whether the Shamblin classification or tumor size are predictive of early and late postoperative neurovascular com... περισσότερα »
The posterior wall of the sinus can be resected to perform frontal sinus cranialization, allowing access to the midline anterior cranial fossa. The posterior wall of the sinus is removed with a high-speed burr in the same way as the anterior wall. At the end of the procedure, the bone flap is sutured with nylon suture material and the pericranium is sutured over the bone flap.
Optimal enlargement of the frontal sinus approach via European Annals of Otorhinolaryngology, Head and Neck Diseases *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): C.A. Righini, I. Atallah, E. Reyt After recalling the main anatomical characteristics of the frontal sinuses, the authors describe the frontal craniotomy surgical procedure and its variants. A bicoronal skin incision is performed. An inferior-based pericranial flap is created, with its limits situated away from the osteotomies. Osteotomies are performed with an oscillating saw. The infer... περισσότερα »
Vestibular evaluation in sequentially implanted children
Interest of vestibular evaluation in sequentially implanted children: Preliminary results via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 30 May 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): B. Devroede, I. Pauwels, S.-D. Le Bon, J. Monstrey, A.-L. Mansbach IntroductionAn early acquired or congenital absence of sensory input of the vestibule will lead to severe delayed posturomotor milestones. Previous studies have proven modifications and even complete ipsilateral loss of vestibular functi... περισσότερα »
The vascular strip is an uncommon source of iatrogenic cholesteatoma that can present years following an otherwise uncomplicated otologic surgery. The findings presented herein highlight the importance of careful vascular strip orientation at the conclusion of otologic surgery.
Iatrogenic cholesteatoma arising from the vascular strip: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis To highlight the phenomenon of cholesteatoma arising from the vascular strip following tympanoplasty and tympanomastoidectomy. Study Design Multi-institutional retrospective chart review. Methods Consecutive adult and pediatric patients evaluated between 2000 and 2015 with acquired cholesteatoma arising from the skin of a prior vascular strip were identified. Patients with evidence of residual or recurrent cholesteatoma elsewhere in the middle ear, mast... περισσότερα »
Iatrogenic cholesteatoma arising from the vascular strip
Iatrogenic cholesteatoma arising from the vascular strip: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis To highlight the phenomenon of cholesteatoma arising from the vascular strip following tympanoplasty and tympanomastoidectomy. Study Design Multi-institutional retrospective chart review. Methods Consecutive adult and pediatric patients evaluated between 2000 and 2015 with acquired cholesteatoma arising from the skin of a prior vascular strip were identified. Patients with evidence of residual or recurrent cholesteatoma elsewhere in the middle ear, mast... περισσότερα »
Caloric and head-impulse tests during the attacks of Meniere's disease
Comparison of Objectives/Hypothesis To aid in diagnosis of Meniere's disease (MD) during the attacks using caloric and head-impulse tests (HITs). Study Design Retrospective case series review. Methods We analyzed the results of bithermal caloric and HITs during the attacks in 16 patients with MD. Quantitative analyses of HITs were conducted using a magnetic search coil technique. Results In unilateral MD (14 patients, 42 semicircular canals), the head impulse gain of the vestibulo-ocular reflex (VOR) was either normal (28 of 42, 67%), decreased (8 of 42, 19%), or increased (6 of 42, ... περισσότερα »
Pediatric drug-induced sleep endoscopy
The current state of [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis The purpose of this investigation was to assess current drug-induced sleep endoscopy (DISE) practice patterns at centers that have published on the technique, to identify areas of agreement, and to identify areas of disagreement that may represent opportunities for improvement and standardization. Study Design Multi-institutional survey. Methods A survey was designed in two phases to evaluate preoperative assessment, intraoperative performance, and postoperative management of patients un... περισσότερα »
Prevention of anterior glottis web with hyaluronic acid derivatives
in rabbit model: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis Validating an antiadhesive strategy to prevent anterior glottic web (AGW) development. Study Design Prospective animal study in rabbits. Methods Fifteen New Zealand white rabbits were randomly divided into three equal groups (five rabbits each), applying either HyFence (HF: 0.1 g/vocal fold), an antiadhesive test agent; mitomycin-C (MMC: 1 mg/ml, 4 min) as reference therapy; or saline (control group) to AGWs induced by laryngofissure technique (previously reported by us). At week 8, the exte... περισσότερα »
Does a specimen-based margin analysis of early tongue cancer better predict local control?
Does a specimen-based margin analysis of early tongue cancer better predict local control?:
Selective stimulation of facial muscles with a penetrating electrode array
in the feline model: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis Permanent facial nerve injury is a difficult challenge for both patients and physicians given its potential for debilitating functional, cosmetic, and psychological sequelae. Although current surgical interventions have provided considerable advancements in facial nerve rehabilitation, they often fail to fully address all impairments. We aim to introduce an alternative approach to facial nerve rehabilitation. Study Design Acute experiments in animals with normal facial function. Methods ... περισσότερα »
Nasal versus tracheobronchial biopsies to diagnose primary ciliary dyskinesia
A meta-analysis: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis To systematically review the literature regarding the efficacy of different biopsy sites and methods to obtain an adequate ciliary sample for ultrastructural examination with electron microscopy (EM) for the diagnosis of primary ciliary dyskinesia (PCD). Study Design Systematic review and meta-analysis. Methods A literature search was conducted with respect to the diagnosis of PCD. English studies with five or more subjects were included. Successful biopsy was defined as an adequate ciliary ... περισσότερα »
Biological significance of genome-wide DNA methylation profiles in keloids
Biological significance of genome-wide DNA methylation profiles in keloids: Objectives/Hypothesis To obtain biological insight into keloid pathogenesis and treatment using pathway analysis of genome-wide differentially methylated gene profiles between keloid and normal skin. Study Design Prospective cohort. Methods Genome-wide profiling was previously done, with institutional review board approval, on six fresh keloid and six fresh normal skin tissue samples, using the Infinium HumanMethylation450 BeadChip kit. Statistically significant differentially methylated cytosine-phosphodiest... περισσότερα »
The anatomy of the glossopharyngeal nerve
A description of the anatomy of the glossopharyngeal nerve as encountered in transoral surgery: [image: cover.gif?v=1&s=18911bcadec2567e9064b19b] Objectives/Hypothesis To illustrate detailed anatomy of the extracranial portion of the glossopharyngeal nerve in the parapharyngeal space as encountered during transoral surgery. Study Design Prospective cadaveric dissection. All dissections were performed transorally and confirmed with transcervical dissection. Methods Eight color-injected cadaveric heads (16 sides) were dissected to demonstrate the course and anatomy of the glossopha... περισσότερα »
Transoral endoscopic nasopharyngectomy with a flexible next-generation robotic surgical system
Transoral endoscopic nasopharyngectomy with a flexible next-generation robotic surgical system: Objectives/Hypothesis To determine the feasibility of transoral endoscopic nasopharyngectomy without division of the soft plate using a flexible, next-generation robotic surgical system. Study Design Preclinical anatomic study using four human cadavers. Methods Transoral resection of the nasopharyngeal wall with en-bloc resection of the cartilaginous Eustachian tube and dissection of the parapharyngeal fat space. Results The first flexible robotic surgical system has recently been describe... περισσότερα »
Treating critical-sized mandibular defects : Osteoprotegerin gene-modified BMSCs with hydroxyapatite scaffold
for treating critical-sized mandibular defects in ovariectomized osteoporotic rats via Acta Biomaterialia Publication date: Available online 16 June 2016 *Source:*Acta Biomaterialia Author(s): Xian Liu, Chongyun Bao, Hockin H.K. Xu, Jian Pan, Jing Hu, Ping Wang, En Luo Women with postmenopausal osteoporosis are at a high risk for fracture as their bone resorption rate exceeds bone formation rate, resulting in decreased bone mineral density and microarchitectural deterioration. Osteoprotegerin (OPG), a known therapeutic agent capable of inhibiting osteoclastogenesis, has been used in... περισσότερα »
Accuracy of Dolphin visual treatment objective (VTO) prediction software on class III patients treated with maxillary advancement and mandibular setback
Dolphin® visual treatment objective (VTO) prediction software is routinely utilized by orthodontists during the treatment planning of orthognathic cases to help predict post-surgical soft tissue changes. Altho... http://ift.tt/1UcsVKU
The success of the different eradication therapy regimens for Pseudomonas aeruginosa in cystic fibrosis
Summary What is known and objective Antibiotic therapy aimed at eradicating *Pseudomonas aeruginosa* (*Pa*), and improved regimens to treat chronic *Pa* infection have played a major role in increasing the median survival of patients with cystic fibrosis (CF). However, different clinical centres use varying eradication regimens. The aim of this study was to evaluate the efficacy of multiple eradication treatments against initial *Pa* infection and to determine the factors affecting the treatment success. Methods This study was conducted at the Hacettepe University Department of ... περισσότερα »
Anaphylaxis Triggers and Treatments by Grade Level and Staff Training: Findings from the EPIPEN4SCHOOLS Pilot Survey
Pediatric Allergy, Immunology, and Pulmonology Jun 2016, Vol. 29, No. 2: 80-85. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1Umfo5G
Lactose Intolerance in Children with IgE-Dependent Allergy to Milk Proteins
Pediatric Allergy, Immunology, and Pulmonology Jun 2016, Vol. 29, No. 2: 86-90. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1OtyOX9
Feasibility of Picture-Based Asthma Medication Plans in Urban Pediatric Outpatient Clinics
Pediatric Allergy, Immunology, and Pulmonology Jun 2016, Vol. 29, No. 2: 95-99. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1UmgzC4
Macrolides for Acute Wheezing Episodes in Preschool Children
Pediatric Allergy, Immunology, and Pulmonology Jun 2016, Vol. 29, No. 2: 100-103. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1OtyQhv
Proof of Concept Study: The Process to New Device Development
Pediatric Allergy, Immunology, and Pulmonology Jun 2016, Vol. 29, No. 2: 59-60. from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1Umh27e
Recombinant Trichinella spiralis 53-kDa protein activates M2 macrophages and attenuates the LPS-induced damage of endotoxemia
Sepsis is a serious clinical condition of excessive systemic immune response to microbial infection. The pro-inflammatory stage of sepsis is generally launched by innate cells such as macrophages. They release inflammatory cytokines, activate other immune cells and cause severe tissue/organ damage. In this study, we have revealed that recombinant *Trichinella spiralis* (TS) excretory–secretory protein (rTsP53) exhibited anti-inflammatory properties and rescued mice from LPS-induced endotoxemia, which is a common model for sepsis study, potentially through the induction of M2 macro... περισσότερα »
Cationic carbon quantum dots derived from alginate for gene delivery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
: one-step synthesis and cellular uptake via Acta Biomaterialia Publication date: Available online 16 June 2016Source:Acta BiomaterialiaAuthor(s): Jie Zhou, Wenwen Deng, Yan Wang, Xia Cao, Jingjing Chen, Qiang Wang, Wenqian Xu, Pan Du, Qingtong Yu, Jiaxin Chen, Myron Spector, Jiangnan Yu, Ximing XuCarbon quantum dots (CQDs), unlike semiconductor quantum dots, possess fine biocompatibility, excellent upconversion properties, […]
Complete Congenital Arhinia
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Nasal reconstruction of a patient with complete congenital arhinia: A clinical report via The Journal of Prosthetic Dentistry Publication date: Available online 16 June 2016Source:The Journal of Prosthetic DentistryAuthor(s): Nelson Fernandes, Jacobus van den Heever, Leanne Sykes, Herman KlugeComplete congenital arhinia is a rare embryonic disorder of unknown etiology. This is a clinical report of the […]
Volume-stable collagen matrix compared to autogenous connective tissue grafts for soft tissue augmentation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Randomized controlled clinical study evaluating effectiveness and safety of a volume-stable collagen matrix compared to autogenous connective tissue grafts for soft tissue augmentation at implant sites: Abstract Aim To test whether or not the use of a collagen matrix (VCMX) results in short-term soft tissue volume increase at implant sites non-inferior to an autogenous subepithelial […]
Transmasculine People’s Voice Function
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
: A Review of the Currently Available Evidence via Voice Publication date: Available online 16 June 2016Source:Journal of VoiceAuthor(s): David Azul, Ulrika Nygren, Maria Södersten, Christiane Neuschaefer-RubeObjectivesThis study aims to evaluate the currently available discursive and empirical data relating to those aspects of transmasculine people’s vocal situations that are not primarily gender-related, to identify restrictions to […]
Usher syndrome type IIa
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
A Combination of Two Truncating Mutations in USH2A causes more Severe and Progressive Hearing Impairment in Usher syndrome type IIa via Hearing Research Publication date: Available online 16 June 2016Source:Hearing ResearchAuthor(s): Bas P. Hartel, Maria Löfgren, Patrick L.M. Huygen, Iris Guchelaar, Nicole Lo-A-Njoe Kort, Andre M. Sadeghi, Erwin van Wijk, Lisbeth Tranebjærg, Hannie Kremer, William J. […]
Development of Auxiliaries in Young Children
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Learning African American English: Purpose We examined language samples of young children learning African American English (AAE) to determine if and when their use of auxiliaries shows dialect-universal and dialect-specific effects. Method The data were longitudinal language samples obtained from two children, ages 18 to 36 months, and three children, ages 33 to 51 months. […]
Temporal Lobe Gliosarcoma After Gamma Knife Radiosurgery for Vestibular Schwannoma.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Temporal Lobe Gliosarcoma After Gamma Knife Radiosurgery for Vestibular Schwannoma.: Objective: Secondary tumorigenesis after exposure to ionizing radiation is a well-described phenomenon. The probability of developing a malignancy after stereotactic radiosurgery (SRS) is theoretically less than conventional external beam radiation therapy; however, the exact risk remains unknown. Such information is important for patient counseling when […]
Stapedotomy With Adipose Tissue Seal: Hearing Outcomes, Incidence of Sensorineural Hearing Loss, and Comparison to Alternative Techniques.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Stapedotomy With Adipose Tissue Seal: Hearing Outcomes, Incidence of Sensorineural Hearing Loss, and Comparison to Alternative Techniques.: Objective: To evaluate hearing outcomes and incidence of sensorineural hearing loss (SNHL) after stapedotomy with adipose tissue seal, and to compare adipose tissue sealing with alternative techniques. Study Design: Retrospective chart review. Setting: Tertiary referral center. Patients: Primary […]
The Impact of Electrode Array Length on Hearing Preservation in Cochlear Implantation.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
The Impact of Electrode Array Length on Hearing Preservation in Cochlear Implantation.: Objective: The aim of the study was to determine the degree of hearing preservation (HP) and its relation to electrode array length after cochlear implantation using different thin flexible electrode arrays (TFEA). Study Design: Retrospective analysis. Intervention: One hundred twenty adult patients with […]
Single occipital nerve blockade in episodic and chronic cluster headache
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Efficacy and safety of a single occipital nerve blockade in episodic and chronic cluster headache: A prospective observational study: Background Treatment options for cluster headache (CH) include acute, transitional and prophylactic strategies. We assessed the efficacy and safety of a single occipital nerve block (ONB) in patients with episodic (eCH) and chronic CH (cCH). Methods […]
Evaluation of esophageal distensibility in eosinophilic esophagitis: an update and comparison of functional lumen imaging probe analytic methods
Abstract Background Distensibility evaluation of the esophageal body using the functional lumen imaging probe (FLIP) offers an objective measure to characterize patients with eosinophilic esophagitis (EoE), though this analysis may be limited by unrecognized catheter movement and esophageal contractility. The aims of this study were to report novel FLIP analytic methods of esophageal distensibility measurement in EoE and to assess the effect of contractility. Methods Nine healthy controls (six female; ages 20–49) and 20 EoE patients (four female; ages 19–64; grouped by degree of dis... περισσότερα »
Effect of external PEEP in patients under controlled mechanical ventilation with an auto-PEEP of 5 cmH2O or higher
In some patients with auto-positive end-expiratory pressure (auto-PEEP), application of PEEP lower than auto-PEEP maintains a constant total PEEP, therefore reducing the inspiratory threshold load without detr... from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1UZg6ms
Immunoglobulin G4–Related Disease: Recent Advances in Pathogenesis and Imaging Findings
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Publication date: May 2016 *Source:*Radiologic Clinics of North America, Volume 54, Issue 3 Author(s): Venkata S. Katabathina, Suhare Khalil, Sooyoung Shin, Narayan Lath, Christine O. Menias, Srinivasa R. Prasad Teaser Immunoglobulin G4–related disease (IgG4-RD) is a novel, immune-mediated, multisystem disease characterized by the development of tumefactive lesions in multiple organs. IgG4-RD encompasses many fibroinflammatory diseases that had been thought to be confined to single organs. Delayed diagnosis or misdiagnosis as malignancies leading to aggressive treatment may be aver... περισσότερα »
Extranodal Lymphoma of the Central Nervous System and Spine
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Publication date: July 2016 *Source:*Radiologic Clinics of North America, Volume 54, Issue 4 Author(s): Kelly K. Koeller, Robert Y. Shih Teaser With a strong predilection for immunocompromised groups and a poorly explained increase in prevalence among those with normal immune status, lymphoma now accounts for approximately 6% of all primary brain tumors. Recent advances in multiagent chemotherapy and monoclonal antibody therapy have promoted longer-term survival, although a definitive cure remains elusive. Extranodal lymphoma of the spine is more often caused by secondary dissemina... περισσότερα »
Primary Extranodal Lymphoma of the Thorax
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Publication date: July 2016 *Source:*Radiologic Clinics of North America, Volume 54, Issue 4 Author(s): Seth J. Kligerman, Teri J. Franks, Jeffrey R. Galvin Teaser Primary pulmonary lymphomas represent a pathologically heterogeneous group of disorders that often share imaging features, which include peribronchovascular nodules and masses or areas of nonresolving consolidation. Primary mediastinal B-cell lymphoma is an extranodal non-Hodgkin lymphoma seen in younger patients that has imaging and pathologic features that demonstrate some degree of overlap with Hodgkin lymphoma. Prima... περισσότερα »
Cardiac Lymphoma
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Publication date: July 2016 *Source:*Radiologic Clinics of North America, Volume 54, Issue 4 Author(s): Jean Jeudy, Allen P. Burke, Aletta Ann Frazier Teaser Lymphoma of the heart and pericardium may develop in up to 25% of patients with disseminated nodal disease, but primary cardiac lymphoma is rare. The majority are diffuse large B-cell lymphomas, which arise in immunocompetent older individuals, men twice as often as women. Subsets are found in immunocompromised patients, including those with HIV-AIDS or allograft recipients. Cardiac lymphomas tend to arise in the wall of the r... περισσότερα »
Can Stereotactic Body Radiation Therapy Be a Viable and Efficient Therapeutic Option for Unresectable Locally Advanced Pancreatic Adenocarcinoma? Results of a Phase 2 Study
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Can Stereotactic Body Radiation Therapy Be a Viable and Efficient Therapeutic Option for Unresectable Locally Advanced Pancreatic Adenocarcinoma? Results of a Phase 2 Study: Purpose: To assess the efficacy of stereotactic body radiotherapy in patients with unresectable locally advanced pancreatic cancer. Materials and Methods: All patients received a prescription dose of 45 Gy in 6 […]
Systemic therapy in muscle-invasive and metastatic bladder cancer: current trends and future promises
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Systemic therapy in muscle-invasive and metastatic bladder cancer: current trends and future promises: Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1YwfFWr via IFTTT
Imaging of local recurrence in prostate cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Imaging of local recurrence in prostate cancer: Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1US4Vio via IFTTT
Serum calcium, albumin and tumor stage in cutaneous malignant melanoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Serum calcium, albumin and tumor stage in cutaneous malignant melanoma: Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Ywg8I9 via IFTTT
Cholecystokinin expression in tumors: biogenetic and diagnostic implications
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Cholecystokinin expression in tumors: biogenetic and diagnostic implications: Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1US6cpB via IFTTT
Phase 1 study of abemaciclib, an inhibitor of CDK 4 and 6, as a single agent for Japanese patients with advanced cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Phase 1 study of abemaciclib, an inhibitor of CDK 4 and 6, as a single agent for Japanese patients with advanced cancer: Abstract Purpose To confirm the safety and tolerability, evaluate the pharmacokinetics (PK), and investigate the antitumor activity of abemaciclib in Japanese patients with advanced cancer. Methods We conducted a non-randomized, single-arm, open-label, dose-escalation […]
Phase 1 study of abemaciclib, an inhibitor of CDK 4 and 6, as a single agent for Japanese patients with advanced cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Purpose To confirm the safety and tolerability, evaluate the pharmacokinetics (PK), and investigate the antitumor activity of abemaciclib in Japanese patients with advanced cancer. Methods We conducted a non-randomized, single-arm, open-label, dose-escalation phase 1 study of abemaciclib administered orally every 12 h (Q12H) on a 28-day cycle at doses of 100 mg (Cohort 1, […]
Serum calcium, albumin and tumor stage in cutaneous malignant melanoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Serum calcium, albumin and tumor stage in cutaneous malignant melanoma: Future Oncology Ahead of Print. from Melanoma2 via ola Kala on Inoreader via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1XYQ6yO via IFTTT
Temporal Lobe Gliosarcoma After Gamma Knife Radiosurgery for Vestibular Schwannoma.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objective: Secondary tumorigenesis after exposure to ionizing radiation is a well-described phenomenon. The probability of developing a malignancy after stereotactic radiosurgery (SRS) is theoretically less than conventional external beam radiation therapy; however, the exact risk remains unknown. Such information is important for patient counseling when considering treatment of benign conditions such as vestibular schwannoma (VS). […]
The Impact of Electrode Array Length on Hearing Preservation in Cochlear Implantation.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Objective: The aim of the study was to determine the degree of hearing preservation (HP) and its relation to electrode array length after cochlear implantation using different thin flexible electrode arrays (TFEA). Study Design: Retrospective analysis. Intervention: One hundred twenty adult patients with preoperative residual hearing received a cochlear implant with a TFEA: 46 received […]
Phase 1 study of abemaciclib, an inhibitor of CDK 4 and 6, as a single agent for Japanese patients with advanced cancer
Abstract Purpose To confirm the safety and tolerability, evaluate the pharmacokinetics (PK), and investigate the antitumor activity of abemaciclib in Japanese patients with advanced cancer. Methods We conducted a non-randomized, single-arm, open-label, dose-escalation phase 1 study of abemaciclib administered orally every 12 h (Q12H) on a 28-day cycle at doses of 100 mg (Cohort 1, *n* = 3), 150 mg (Cohort 2, *n* = 3), or 200 mg [Cohort 3, *n* = 6, maximum tolerated dose (MTD)]. Dose escalation was based on the frequency of dose-limiting toxicity (DLT). MTD, as established in the ... περισσότερα »
Effect of external PEEP in patients under controlled mechanical ventilation with an auto-PEEP of 5 cmH2O or higher
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 2 ώρες
In some patients with auto-positive end-expiratory pressure (auto-PEEP), application of PEEP lower than auto-PEEP maintains a constant total PEEP, therefore reducing the inspiratory threshold load without detr… from Emergencies via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UZg6ms via IFTTT
Superior sulcus non-small cell lung carcinoma: A comparison of IMRT and 3D-RT dosimetry
Publication date: September–October 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 5 Author(s): Pierre Truntzer, Delphine Antoni, Nicola Santelmo, Catherine Schumacher, Pierre-Emmanuel Falcoz, Elisabeth Quoix, Gilbert Massard, Georges Noël AimA dosimetric study comparing intensity modulated radiotherapy (IMRT) by TomoTherapy to conformational 3D radiotherapy (3D-RT) in patients with superior sulcus non-small cell lung cancer (NSCLC).BackgroundIMRT became the main technique in modern radiotherapy. However it was not currently used for lung cancers. Because... περισσότερα »
Volumetric Modulated Arc Therapy (VMAT) make a difference in retro-orbital irradiation treatment of patients with bilateral Graves’ ophthalmopathy. Comparative analysis of dosimetric parameters from different radiation techniques
Publication date: September–October 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 5 Author(s): Iñigo San-Miguel, Ruth Carmona, Luis Luque, Raquel Cabrera, Marta Lloret, Francisco Rutllan, Pedro Carlos Lara BackgroundGraves’ ophthalmopathy is the commonest extrathyroidal manifestation of Graves’ disease. Treatment options include steroid therapy, corrective/decompressive surgery, radiation therapy or combination of these approaches.AimOur purpose was to investigate if retro-orbital irradiation with Volumetric Modulated Arc Therapy (VMAT) yielded better ta... περισσότερα »
Influence of the contrast agents on treatment planning dose calculations of prostate and rectal cancers
Publication date: September–October 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 5 Author(s): Sahel Heydarheydari, Negin Farshchian, Abbas Haghparast AimThe aim of the present study is to quantify differences in dose calculations caused by using CA and determine if the resulting differences are clinically significant.BackgroundThe influence of contrast agents (CA) on radiation dose calculations must be taken into account in treatment planning.Materials and methodsEleven patients with pelvic cancers were included in this study and two sets of CTs were tak... περισσότερα »
Study of the dosimetric differences between 192Ir and 60Co sources of high dose rate brachytherapy for breast interstitial implant
Publication date: September–October 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 5 Author(s): Mourougan Sinnatamby, Vivekanandan Nagarajan, Reddy Kanipakam Sathyanarayana, Gunaseelan Karunanidhi, Vivekanandam Singhavajala AimThe study intends to compare 192Ir source against the 60Co source for interstitial breast metal implant in high dose rate brachytherapy.BackgroundFew studies have been reported to compare 60Co and 192Ir on HDR brachytherapy in gynaecology and prostate cancer and very few with reference to breast cancer.Materials and methodsTwenty pat... περισσότερα »
Impact of reduction of flux overlap region on kilovoltage cone-beam computed tomography image quality and patients’ exposure dose
Publication date: September–October 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 5 Author(s): Daisuke Kawahara, Shuichi Ozawa, Yuji Murakami, Takeo Nakashima, Masamichi Aita, Shintaro Tsuda, Yusuke Ochi, Takuro Okumura, Hirokazu Masuda, Yoshimi Ohno, Yasushi Nagata AimIn high-precision radiation therapy, kilovoltage cone-beam computed tomography plays an important role in verifying the position of patient and localization of the target. However, the exposure dose is a problem with kilovoltage cone-beam computed tomography. Flux overlap region increases ... περισσότερα »
Tumour volumes: Predictors of early treatment response in locally advanced head and neck cancers treated with definitive chemoradiation
Publication date: September–October 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 5 Author(s): Parveen Ahlawat, Sheh Rawat, Anjali Kakria, Manoj Pal, Deepika Chauhan, Sarthak Tandon, Shraddha Jain AimTo analyse and predict early response 3 months post definitive chemoradiation (CCRT) utilising tumour volume (TV) measurement in locally advanced head and neck cancers (LAHNC).BackgroundLAHNC are 3-dimentional lesions. The largest diameter of these tumours measured for T-classification may not necessarily reflect the true tumour dimensions. TV accurately ref... περισσότερα »
Comparison of set-up errors by breast size on wing board by portal imaging
Publication date: September–October 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 5 Author(s): Waseem Raza, Sushma Agarwal, Koilpillai Joseph Maria Das, Sellepolyam Kaliyaperumal Senthil Kumar, Punita Lal AimTo quantify and compare setup errors between small and large breast patients undergoing intact breast radiotherapy.Methods20 patients were inducted. 10 small/moderate size breast in arm I and 10 large breast in arm II. Two orthogonal and one lateral tangent portal images (PIs) were obtained and analyzed for systematic (Σ) and random (σ) errors. Effect... περισσότερα »
Editorial board
Publication date: July–August 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 4 from Rathiotherapy via xlomafota13 on Inoreader http://ift.tt/1XsD2AV
Historical development of the treatment of skull base tumours
Publication date: July–August 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 4 Author(s): Antonio Mazzoni, Marco Krengli Surgery has evolved greatly over the last decades thanks to the more sophisticated and conservative surgical approaches and also thanks to the progress of diagnostic imaging. An added value is represented by the increased experience of the professionals and the close multidisciplinarity of the procedures including neurosurgeons, otolaryngologists and maxillo-facial surgeons. One of the most recent developments is the endoscopic surgery ... περισσότερα »
Surgical management of skull base tumors
Publication date: July–August 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 4 Author(s): Leonardo Rangel-Castilla, Jonathan J. Russin, Robert F. Spetzler AimTo present a review of the contemporary surgical management of skull base tumors.BackgroundOver the last two decades, the treatment of skull base tumors has evolved from observation, to partial resection combined with other therapy modalities, to gross total resection and no adjuvant treatment with good surgical results and excellent clinical outcomes.Materials and methodsThe literature review of curr... περισσότερα »
Review of photon and proton radiotherapy for skull base tumours
Publication date: July–August 2016 *Source:*Reports of Practical Oncology & Radiotherapy, Volume 21, Issue 4 Author(s): Piero Fossati, Andrea Vavassori, Letizia Deantonio, Eleonora Ferrara, Marco Krengli, Roberto Orecchia An extremely large variety of benign and malignant tumours occur at skull base; these tumour lesions are in the proximity to structures deputed to relevant physiologic functions, limiting extensive surgical approaches to this body district. Most recent progresses of surgery and radiotherapy have allowed to improve local control with acceptable rates of side effects. ... περισσότερα »
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