The Role of Training Structure in Perceptual Learning of Accented Speech.
*The Role of Training Structure in Perceptual Learning of Accented Speech.* J Exp Psychol Hum Percept Perform. 2016 Jul 11; Authors: Tzeng CY, Alexander JE, Sidaras SK, Nygaard LC Abstract Foreign-accented speech contains multiple sources of variation that listeners learn to accommodate. Extending previous findings showing that exposure to high-variation training facilitates perceptual learning of accented speech, the current study examines to what extent the structure of training materials affects learning. During training, native adult speakers of American English transcribed se... περισσότερα »
From Widely Accepted Concepts in Coordination Chemistry to Inverted Ligand Fields.
*From Widely Accepted Concepts in Coordination Chemistry to Inverted Ligand Fields.* Chem Rev. 2016 Jul 11; Authors: Hoffmann R, Alvarez S, Mealli C, Falceto A, Cahill TJ, Zeng T, Manca G Abstract We begin with a brief historical review of the development of our understanding of the normal ordering of nd orbitals of a transition metal interacting with ligands, the most common cases being three below two in an octahedral environment, two below three in tetrahedral coordination, and four below one in a square-planar environment. From the molecular orbital construction of these lig... περισσότερα »
I'm Still Me: Inspiration and Instruction from Individuals with Brain Cancer.
*I'm Still Me: Inspiration and Instruction from Individuals with Brain Cancer.* J Health Care Chaplain. 2016 Jul 11;:1-19 Authors: Piderman KM, Egginton JS, Ingram C, Dose AM, Yoder TJ, Lovejoy LA, Swanson SW, Hogg JT, Lapid MI, Jatoi A, Remtema MS, Tata BS, Breitkopf CR Abstract Individuals with brain cancer face many challenges, including threats to cognition, personality, and sensory and motor functioning. These can alter one's sense of identity and result in despair. Chaplain-led spiritual interviews were conducted with 19 patients with brain cancer as part of a larger spirit... περισσότερα »
Video-Assisted Thoracoscopic Resection of a Noninvasive Thymoma in a Cat with Myasthenia Gravis Using Low-Pressure Carbon Dioxide Insufflation.
*Video-Assisted Thoracoscopic Resection of a Noninvasive Thymoma in a Cat with Myasthenia Gravis Using Low-Pressure Carbon Dioxide Insufflation.* Vet Surg. 2016 Jul 11; Authors: Griffin MA, Sutton JS, Hunt GB, Pypendop BH, Mayhew PD Abstract OBJECTIVE: To report the use of low-pressure carbon dioxide insufflation during video-assisted thoracoscopic surgery for resection of a noninvasive thymoma in a cat with secondary myasthenia gravis. STUDY DESIGN: Clinical case report. ANIMAL: Client-owned cat. METHODS: An 11-year-old castrated male domestic shorthair cat was examined for genera... περισσότερα »
Human Speech: A Restricted Use of the Mammalian Larynx.
*Human Speech: A Restricted Use of the Mammalian Larynx.* J Voice. 2016 Jul 7; Authors: Titze IR Abstract PURPOSE: Speech has been hailed as unique to human evolution. Although the inventory of distinct sounds producible with vocal tract articulators is a great advantage in human oral communication, it is argued here that the larynx as a sound source in speech is limited in its range and capability because a low fundamental frequency is ideal for phonemic intelligibility and source-filter independence. METHOD: Four existing data sets were combined to make an argument regarding ex... περισσότερα »
The Psychometric Properties of the Voice Handicap Index in People With Parkinson's Disease.
*The Psychometric Properties of the Voice Handicap Index in People With Parkinson's Disease.* J Voice. 2016 Jul 7; Authors: Guimaraes I, Cardoso R, Pinto S, Ferreira JJ Abstract BACKGROUND: Psychosocial impact of dysphonia in people with Parkinson disease (PD) has been described with the Voice Handicap Index (VHI); however, its psychometric properties when applied in this population are not described. OBJECTIVE: The objective of this study was to examine the psychometric properties of the VHI in people with PD. METHODS: A cross-sectional study of 151 subjects without cognitive im... περισσότερα »
Fundamental Frequency Variation in Crying of Mandarin and German Neonates.
*Fundamental Frequency Variation in Crying of Mandarin and German Neonates.* J Voice. 2016 Jul 7; Authors: Wermke K, Ruan Y, Feng Y, Dobnig D, Stephan S, Wermke P, Ma L, Chang H, Liu Y, Hesse V, Shu H Abstract OBJECTIVES: This study examined whether prenatal exposure to either a tonal or a nontonal maternal language affects fundamental frequency (fo) properties in neonatal crying. STUDY DESIGN: This is a population prospective study. PARTICIPANTS: A total of 102 neonates within the first week of life served as the participants. METHODS: Spontaneously uttered cries (N = 6480) by Chi... περισσότερα »
Dramatically Enhanced Mechanosensitivity and Signal-to-Noise Ratio of Nanoscale Crack-Based Sensors: Effect of Crack Depth.
*Dramatically Enhanced Mechanosensitivity and Signal-to-Noise Ratio of Nanoscale Crack-Based Sensors: Effect of Crack Depth.* Adv Mater. 2016 Jul 11; Authors: Park B, Kim J, Kang D, Jeong C, Kim KS, Kim JU, Yoo PJ, Kim TI Abstract The sensitivity of a nanoscale crack-based sensor is enhanced markedly by modulating crack depth. The crack depth-propagated sensor exhibits ≈16 000 gauge factor at 2% strain and a superior signal-to-noise ratio of ≈35, which facilitates detection of target signals for voice pattern recognition. PMID: 27396592 [PubMed - as supplied by publisher] from S... περισσότερα »
Reappraising the voices of wrath.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Reappraising the voices of wrath.* Soc Cogn Affect Neurosci. 2015 Dec;10(12):1644-60 Authors: Korb S, Frühholz S, Grandjean D Abstract Cognitive reappraisal recruits prefrontal and parietal cortical areas. Because of the near exclusive usage in past research of visual stimuli to elicit emotions, it is unknown whether the same neural substrates underlie the reappraisal of emotions induced through other sensory modalities. Here, participants reappraised their emotions in order to increase or decrease their emotiona... περισσότερα »
The Role of Training Structure in Perceptual Learning of Accented Speech.
*The Role of Training Structure in Perceptual Learning of Accented Speech.* J Exp Psychol Hum Percept Perform. 2016 Jul 11; Authors: Tzeng CY, Alexander JE, Sidaras SK, Nygaard LC Abstract Foreign-accented speech contains multiple sources of variation that listeners learn to accommodate. Extending previous findings showing that exposure to high-variation training facilitates perceptual learning of accented speech, the current study examines to what extent the structure of training materials affects learning. During training, native adult speakers of American English transcribed se... περισσότερα »
From Widely Accepted Concepts in Coordination Chemistry to Inverted Ligand Fields.
*From Widely Accepted Concepts in Coordination Chemistry to Inverted Ligand Fields.* Chem Rev. 2016 Jul 11; Authors: Hoffmann R, Alvarez S, Mealli C, Falceto A, Cahill TJ, Zeng T, Manca G Abstract We begin with a brief historical review of the development of our understanding of the normal ordering of nd orbitals of a transition metal interacting with ligands, the most common cases being three below two in an octahedral environment, two below three in tetrahedral coordination, and four below one in a square-planar environment. From the molecular orbital construction of these lig... περισσότερα »
I'm Still Me: Inspiration and Instruction from Individuals with Brain Cancer.
*I'm Still Me: Inspiration and Instruction from Individuals with Brain Cancer.* J Health Care Chaplain. 2016 Jul 11;:1-19 Authors: Piderman KM, Egginton JS, Ingram C, Dose AM, Yoder TJ, Lovejoy LA, Swanson SW, Hogg JT, Lapid MI, Jatoi A, Remtema MS, Tata BS, Breitkopf CR Abstract Individuals with brain cancer face many challenges, including threats to cognition, personality, and sensory and motor functioning. These can alter one's sense of identity and result in despair. Chaplain-led spiritual interviews were conducted with 19 patients with brain cancer as part of a larger spirit... περισσότερα »
Video-Assisted Thoracoscopic Resection of a Noninvasive Thymoma in a Cat with Myasthenia Gravis Using Low-Pressure Carbon Dioxide Insufflation.
*Video-Assisted Thoracoscopic Resection of a Noninvasive Thymoma in a Cat with Myasthenia Gravis Using Low-Pressure Carbon Dioxide Insufflation.* Vet Surg. 2016 Jul 11; Authors: Griffin MA, Sutton JS, Hunt GB, Pypendop BH, Mayhew PD Abstract OBJECTIVE: To report the use of low-pressure carbon dioxide insufflation during video-assisted thoracoscopic surgery for resection of a noninvasive thymoma in a cat with secondary myasthenia gravis. STUDY DESIGN: Clinical case report. ANIMAL: Client-owned cat. METHODS: An 11-year-old castrated male domestic shorthair cat was examined for genera... περισσότερα »
Human Speech: A Restricted Use of the Mammalian Larynx.
*Human Speech: A Restricted Use of the Mammalian Larynx.* J Voice. 2016 Jul 7; Authors: Titze IR Abstract PURPOSE: Speech has been hailed as unique to human evolution. Although the inventory of distinct sounds producible with vocal tract articulators is a great advantage in human oral communication, it is argued here that the larynx as a sound source in speech is limited in its range and capability because a low fundamental frequency is ideal for phonemic intelligibility and source-filter independence. METHOD: Four existing data sets were combined to make an argument regarding ex... περισσότερα »
The Psychometric Properties of the Voice Handicap Index in People With Parkinson's Disease.
*The Psychometric Properties of the Voice Handicap Index in People With Parkinson's Disease.* J Voice. 2016 Jul 7; Authors: Guimaraes I, Cardoso R, Pinto S, Ferreira JJ Abstract BACKGROUND: Psychosocial impact of dysphonia in people with Parkinson disease (PD) has been described with the Voice Handicap Index (VHI); however, its psychometric properties when applied in this population are not described. OBJECTIVE: The objective of this study was to examine the psychometric properties of the VHI in people with PD. METHODS: A cross-sectional study of 151 subjects without cognitive im... περισσότερα »
Fundamental Frequency Variation in Crying of Mandarin and German Neonates.
*Fundamental Frequency Variation in Crying of Mandarin and German Neonates.* J Voice. 2016 Jul 7; Authors: Wermke K, Ruan Y, Feng Y, Dobnig D, Stephan S, Wermke P, Ma L, Chang H, Liu Y, Hesse V, Shu H Abstract OBJECTIVES: This study examined whether prenatal exposure to either a tonal or a nontonal maternal language affects fundamental frequency (fo) properties in neonatal crying. STUDY DESIGN: This is a population prospective study. PARTICIPANTS: A total of 102 neonates within the first week of life served as the participants. METHODS: Spontaneously uttered cries (N = 6480) by Chi... περισσότερα »
Dramatically Enhanced Mechanosensitivity and Signal-to-Noise Ratio of Nanoscale Crack-Based Sensors: Effect of Crack Depth.
*Dramatically Enhanced Mechanosensitivity and Signal-to-Noise Ratio of Nanoscale Crack-Based Sensors: Effect of Crack Depth.* Adv Mater. 2016 Jul 11; Authors: Park B, Kim J, Kang D, Jeong C, Kim KS, Kim JU, Yoo PJ, Kim TI Abstract The sensitivity of a nanoscale crack-based sensor is enhanced markedly by modulating crack depth. The crack depth-propagated sensor exhibits ≈16 000 gauge factor at 2% strain and a superior signal-to-noise ratio of ≈35, which facilitates detection of target signals for voice pattern recognition. PMID: 27396592 [PubMed - as supplied by publisher] from S... περισσότερα »
Reappraising the voices of wrath.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Reappraising the voices of wrath.* Soc Cogn Affect Neurosci. 2015 Dec;10(12):1644-60 Authors: Korb S, Frühholz S, Grandjean D Abstract Cognitive reappraisal recruits prefrontal and parietal cortical areas. Because of the near exclusive usage in past research of visual stimuli to elicit emotions, it is unknown whether the same neural substrates underlie the reappraisal of emotions induced through other sensory modalities. Here, participants reappraised their emotions in order to increase or decrease their emotional... περισσότερα »
Inherited Metabolic Disorders
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Metabolic Disorders
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Inborn Metabolism Error
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Drug Targets
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Metabolism
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Pediatrics and Neonatology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Geriatric Medicine
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Immunostimulants
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Immunodeficiency Disorders
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Autoimmunity
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Autoimmune disorders
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Natural Killer Cells
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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B-lymphocytes
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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T-Lymphocytes
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Eosinophils
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Interleukins
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Interferons
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Cytokines
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Non-Specific Cellular Response
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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The Acquired Immune System
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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The Innate immune system
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Monocytes and Macrophages
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Immunoglobulin E
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Immunoglobulin G
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Lymphocytes
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 6 δευτερόλεπτα
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Rare Cancers : Acta Neurochir (Wien) 1 Am J Case Rep 7 Am J Med 1 Am J Med Sci 1 Am Surg 1 An Sist Sanit Navar 2 Ann Hematol 1 Ann Surg Oncol 1 Ann Thorac Surg 1 Anticancer Drugs 1 Anticancer Res 1 Arch Dermatol Res 1 Arch Orthop Trauma Surg 1 Arq Bras Oftalmol 2 Asian Cardiovasc Thorac Ann 1 Asian J Neurosurg 1 BJU Int 1 Blood 1 BMC Cancer 1 BMC Infect Dis 1 BMC Res Notes 2 BMJ Case Rep 10 Br J Dermatol 1 Br J Haematol 2 Brain Res 1 Bull Acad Natl Med 1 Cancer 2 Cancer Sci 1 Cardiovasc J Afr 1 Chirurg 1 Clin Biochem 2 Clin Immunol 1 Clin Transl Oncol 1 Crit Rev Oncog 3 Curr Oncol Rep 1 Curr Urol Rep 1 Diagn Cytopathol 5 Diagn Pathol 1 Eur J Dermatol 1 Eur J Obstet Gynecol Reprod Biol 1 Eur J Pediatr Surg 1 Eur Rev Med Pharmacol Sci 1 Exp Cell Res 1 Front Horm Res 1 Front Oncol 1 Genet Epidemiol 1 Ginekol Pol 1 Gynecol Oncol 2 Gynecol Oncol Rep 3 Head Neck 1 Hematol Oncol 2 Hematol Oncol Stem Cell Ther 1 Histopathology 1 Horm Metab Res 1 HPB (Oxford) 1 Hum Mol Genet 1 Hum Reprod 1 Immunotherapy 1 Indian J Otolaryngol Head Neck Surg 1 Infect Dis (Lond) 1 Int J Cancer 1 Int J Surg Case Rep 4 Int Orthop 2 Interact Cardiovasc Thorac Surg 1 Iran J Cancer Prev 2 Iran J Med Sci 1 J Bone Miner Res 1 J Bras Pneumol 1 J Bronchology Interv Pulmonol 1 J BUON 2 J Cancer 1 J Clin Immunol 1 J Clin Neurosci 1 J Clin Rheumatol 1 J Craniofac Surg 1 J Endocrinol Invest 1 J Eur Acad Dermatol Venereol 1 J Exp Clin Cancer Res 1 J Gastrointest Surg 1 J Infect Chemother 1 J Intern Med 1 J Natl Med Assoc 1 J Neurooncol 2 J Pediatr Surg 1 J Perinatol 1 J Surg Oncol 1 J Surg Res 1 Kulak Burun Bogaz Ihtis Derg 1 Laryngorhinootologie 1 Laryngoscope 2 Lepr Rev 1 Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 5 Malays J Pathol 4 Medicine (Baltimore) 4 Mod Pathol 1 Mol Clin Oncol 2 Mol Vis 1 Nat Cell Biol 1 Nat Commun 2 Nat Genet 1 Nature 1 Neurol Res 1 Neurol Sci 1 Neurosurg Focus 2 Neurosurgery 1 Nucl Med Commun 2 Nutr Cancer 1 Onco Targets Ther 1 Oncologist 1 Oral Oncol 2 Orthop Traumatol Surg Res 1 Orthopedics 1 Pathol Biol (Paris) 2 Pathologe 1 PLoS One 3 Pol Merkur Lekarski 1 Rev Esp Med Nucl Imagen Mol 7 Rev Mal Respir 1 Rev Pneumol Clin 1 Sao Paulo Med J 1 Sci Rep 1 Spine J 1 Surg Endosc 1 Syst Biol Reprod Med 1 Taiwan J Obstet Gynecol 2 Transplant Proc 2 Wien Klin Wochenschr 1 World J Surg 1 World J Surg Oncol 1 World Neurosurg 5 Zhongguo Shi Yan Xue Ye Xue Za Zhi 1
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* pubmed: rare cancers *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in ... περισσότερα »
Open chromatin profiling key to identifying leukaemia cells of origin
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Every cancer starts with a single cell, and Jackson Laboratory (JAX) researchers have found a precise and reliable way — whole-genome profiling of open chromatin — to identify the kind of cell that leads to a given case of leukaemia, a valuable key to… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29Kpr5K via IFTTT Medicine by […]
Preventive procedure for ovarian cancer adopted without adverse surgical outcomes
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
A surgical procedure recommended to reduce the future risk of ovarian cancer has been successfully implemented throughout Kaiser Permanente in Northern California without a change in surgical outcomes, according to research published today in the journal… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29LAf51 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & […]
Editorial Board
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Publication date: September 2016 Source:Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, Volume 1863, Issue 9 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29Nz8i6 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Providing a valuable update on this complex topic – read our latest Special Issue here: https://t.co/qNzEZ96GBV https://t.co/log1JBg3hO
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Providing a valuable update on this complex topic – read our latest Special Issue here: https://t.co/qNzEZ96GBV https://t.co/log1JBg3hO from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/752838710341885952 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Don’t forget to apply for the @uicc YY Fellowship, deadline 15th July https://t.co/ZYCVGBhfXb https://t.co/Y3kMacFW8Y
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Don’t forget to apply for the @uicc YY Fellowship, deadline 15th July https://t.co/ZYCVGBhfXb https://t.co/Y3kMacFW8Y from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/752827545813385216 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
There’s still time to register for #ecancercolombia! Visit https://t.co/JbYeO42w3L for all the details. https://t.co/OtY98xl17c
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
There’s still time to register for #ecancercolombia! Visit https://t.co/JbYeO42w3L for all the details. https://t.co/OtY98xl17c from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/752825809069637632 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Watch our interview with Dr Hazenberg on the use of antibodies isolated from AML patients: https://t.co/o4yUDDhWVY https://t.co/2ZkB5qSAXJ
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Watch our interview with Dr Hazenberg on the use of antibodies isolated from AML patients: https://t.co/o4yUDDhWVY https://t.co/2ZkB5qSAXJ from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/752823197666455552 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Our latest editorial on open science provides an interesting look at the #reproducibilitycrisis : https://t.co/DUWYeZEgIE
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Our latest editorial on open science provides an interesting look at the #reproducibilitycrisis : https://t.co/DUWYeZEgIE from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/752820572816543745 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Ultra high-frequency ultrasound: New capabilities for nail anatomy exploration
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
Abstract Recent development of ultra high-resolution ultrasound systems, with frequencies as high as 70 MHz and capability resolution as fine as 30 μm, could permit new diagnostic applications to small parts. A variety of superficial targets within the first 1 cm of the skin surface could be imaged, including dermatological applications such as assessment of […]
Juvenile temporal arteritis with eosinophilia associated with systemic sclerosis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 12 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/29BnYwh via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Journal roundup
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29uBAbM
CD28 days later: Resurrecting costimulation for CD8+ memory T cells
Rapid activation and proliferative expansion of specific CD8+ memory T (CD8+ TM) cells upon antigen re-encounter is a critical component of the adaptive immune response that confers enhanced immune protection. In this context, however, the requirements for costimulation in general, and CD28 signaling in particular, remain incompletely defined. In the current issue of the *European Journal of Immunology*, Fröhlich *et al*. [Eur. J. Immunol. 2016. 46: 1644-1655] provide definitive evidence that optimal elaboration of CD8+TM-cell recall responses is indeed contingent on CD28 expressed... περισσότερα »
Found in translation – EJI gets a facelift
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29uBMbb
Contents: Eur. J. Immunol. 7'16
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29tm7N4
50th Anniversary of the French Society for Immunology (SFI)
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29uBMYJ
In this issue
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29tlR0e
Impressum
from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/29uBmS6
Cover Picture: Eur. J. Immunol. 7'16
[image: Thumbnail image of graphical abstract] Our cover features a periodic acid schiff staining of kidney sections from *Candida albicans*-infected Ja18−/− mice. Accumulation of inflammatory cells were observed around the colonies of *C. albicans*. The image is taken from Haraguchi et al. (pp. 1691–1703), where the authors show that Ja18−/− mice are highly resistant to candidiasis. iNKT cells may increase the initial severity of *C. albicans* infection by modulating innate immune responses, especially by suppressing macrophage antifungal activity. Thus, iNKT cells are an importan... περισσότερα »
Back Cover: Eur. J. Immunol. 7'16
[image: Thumbnail image of graphical abstract] Our back cover features Luxol Fast Blue and H&E stainings of lumbar spinal cord from galectin-1 deficient (*Lgals1*−/−) mice. Mice were immunized to induce experimental autoimmune encephalomyelitis (EAE) and treated with intravenous autoantigen. Demyelination and inflammation are apparent in the white matter of *Lgals1*−/− mice but is not present in C57BL/6 EAE mice treated with intravenous autoantigen. The image is taken from Mari et al. (pp. 1783–1796), where the authors present for the first time a role for galectin-1 in the inducti... περισσότερα »
Beam diffraction effects in sound transmission of a fluid-embedded viscoelastic plate at normal incidence
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
The characteristics of a sound beam transmitted through a fluid-embedded viscoelastic plate at normal incidence can deviate significantly from those of a plane-wave. Phenomena such as frequency shift, signal amplification or reduction, and changed beam properties, are observed for resonance peaks associated with specific leaky Lamb modes. When interpreting measurements using plane-wave theory, such deviations will influence the measurement of material parameters and plate thickness. The finite-element-based models used in this study describe the signal chain from the electrical vol... περισσότερα »
Release from masking for small spatial separations: Effects of age and hearing lossa)
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Spatially separating target and masking speech can result in substantial spatial release from masking (SRM) for normal-hearing listeners. In this study, SRM was examined at eight spatial configurations of azimuth angle: maskers co-located with the target (0°) or symmetrically separated by 2°, 4°, 6°, 8°, 10°, 15°, or 30°. Results revealed that different listening groups (young normal-hearing, older normal-hearing, and older hearing-impaired) required different minimum amounts of spatial separation between target and maskers to achieve SRM. The results also indicated that aging was... περισσότερα »
The effect of microphone wind noise on the amplitude modulation of wind turbine noise and its mitigation
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Microphone wind noise can corrupt outdoor recordings even when wind shields are used. When monitoring wind turbine noise, microphone wind noise is almost inevitable because measurements cannot be made in still conditions. The effect of microphone wind noise on two amplitude modulation (AM) metrics is quantified in a simulation, showing that even at low wind speeds of 2.5 m/s errors of over 4 dBA can result. As microphone wind noise is intermittent, a wind noise detection algorithm is used to automatically find uncorrupted sections of the recording, and so recover the true AM metri... περισσότερα »
Injectable Liposomal Formulations: Systematic Analysis for Regulatory Purposes
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Background: Among the drug delivery systems, liposomes stand out for their biocompatible and biodegradable characteristics and high versatility. There are many marketed liposomal drug products, most of them injectables. From a regulatory perspective, some documents were published by FDA and EMA, but a systematic analysis of the factors influencing efficacy, toxicity and stability of injectable liposomal drug products has not yet been carried out in order to identify regulatory relevant items. <p> Method: We use cause and effect diagrams (Ishikawa) to provide knowledge for regul...</p>
Psychosocial distress and its effects on the health-related quality of life of primary brain tumor patients.
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
*Psychosocial distress and its effects on the health-related quality of life of primary brain tumor patients.* CNS Oncol. 2016 Jul 11; Authors: Randazzo D, Peters KB Abstract All cancer patients experience distress from the diagnosis, the effects of the disease or the treatment. Clinically significant distress decreases overall quality of life and the recognition of distress with prompt intervention is essential. The National Comprehensive Cancer Network distress thermometer (NCCN-DT) is a validated measuring tool that has been utilized in the primary brain tumor population to de... περισσότερα »
Pharmacological Benefits of Active Components of Natural Products Against Traumatic Brain Injury - A Review
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Background: Since the last decade, the therapeutic potentials of natural phenolic antioxidants in human diseases associated with oxidative damage have received great attention. Within the last few years, a rapidly growing number of natural compounds with neuro-protective effects have been described. Many efforts have been made to explore the mechanisms for the neuro-protective properties of natural compounds. This review focuses on the beneficial effects of natural products in treating traumatic brain injury (TBI). Numerous epidemiological studies have shown consistent health bene... περισσότερα »
An Anti-apoE4 Specific Monoclonal Antibody Counteracts the Pathological Effects of apoE4 In Vivo
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
ApolipoproteinE4 (apoE4) is the most prevalent genetic risk factor for Alzheimer’s disease (AD) and as such is a promising therapeutic target. This study examined the extent to which the pathological effects of apoE4 can be counteracted in vivo utilizing an immunological approach in which anti-apoE4 antibodies are applied peripherally by i.p. injections into apoE4-targeted replacement mice. Prerequisites for the successful pursuit of this objective are the availability of antibodies that specifically bind brain apoE4 and not apoE3, and demonstrating that direct application of thes... περισσότερα »
Magnetic Nanoparticles in Medical Diagnostic Applications: Synthesis, Characterization and Proteins Conjugation
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Background: Magnetic nanoparticles (NPs) used in biomedical applications should be discrete with small particle sizes, narrow size distribution and superparamagnetic. NPs can be tailored to target, through chemical bonds, specific organs, cells, or even molecular markers of different diseases in vivo, with suitable surface chemistry modification. <p> Methods: Nanoparticles are synthesized by a low cost coprecipitation reaction of ferrous and ferric salts with alkaline solution. The characteristics of the NPs are modified by varying the addition rate of the alkaline solution. NP...</p>
Rice-Product Technology Transfer from Developing to Developed Countries
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Background: Rice is the staple food in the area called the monsoon Asia because of its high yield favored by the sun and rain. The rice agriculture is crucially important to Japan for food security; meanwhile, the imported wheat is cheaper than the domestic rice. The irony is the need to reserve rice agriculture despite the oversupply of rice because of cheap wheat from USA. <p> Objective: To prepare for a bad harvest due to a bad weather, Japan needs to reserve rice agriculture even when wheat can be cheaply imported. This paper proposes a possible policy for Japan to receive ...</p>
Reversal of Oxidative Stress in Neural Cells by an Injectable Curcumin/Thermosensitive Hydrogel
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Curcumin as an antioxidative agent which has been widely used medicinally in India and China. However, rapid metabolism coupled with the instability of curcumin under physiological conditions has greatly limited its applications in vivo. In the present study, a thermosensitive hydrogel with high payload of curcumin was developed by using a co-precipitation method, and its reversion of oxidative stress in Neuro-2a cells was investigated. With an increase in drug loading capacity, the solgel transition temperature of the thermosensitive hydrogel decreased accordingly. The stability ... περισσότερα »
Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
The history of metal based cytostatics began in the 1970s by discovering the effects of cisplatin. Since then several generations of platinum based cytostatics have started to be the key weapon against tumor development and metastasis occurrence. Nevertheless, some attention has been also paid to non-platinum metals, such as ruthenium, titanium, gallium, iron, cobalt, gold, and palladium. Ruthenium, titanium, and gallium complexes have been also tested in clinical studies. This boom in metal based cytostatics can be explained by great effort paid to the elucidation of mechanisms of... περισσότερα »
In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer’s Disease Treatment
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Alzheimer’s disease (AD) is the most frequent cause of dementia, especially in the elderly. AD is the most common progressive neurodegenerative disorder, which involves the loss of structure and function of cholinergic neurons. Moreover, if these neuronal changes cannot be compensated, this may ultimately lead to neurodegenerative processes. Therefore, most of the drug therapies are based on the cholinergic hypothesis, which suggests that AD begins as a deficiency in the production of the neurotransmitter acetylcholine. In this context, many inhibitors play an important role in AD... περισσότερα »
The Production of Solid Dosage Forms from Non-Degradable Polymers
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Non-degradable polymers have an important function in medicine. Solid dosage forms for longer term implantation require to be constructed from materials that will not degrade or erode over time and also offer the utmost biocompatibility and biostability. This review details the three most important non-degradable polymers for the production of solid dosage forms – silicone elastomer, ethylene vinyl acetate and thermoplastic polyurethane. The hydrophobic, thermoset silicone elastomer is utilised in the production of a broad range of devices, from urinary catheter tubing for the pre... περισσότερα »
Microcirculation Alteration and Biomarker Dilemma in Early Septic Shock Diagnosis and Treatment
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Introduction: Septic shock is represented by severe hemodynamic changes which are manifested with failure of organ systems and high mortality. Early diagnosis together with timely and appropriate treatment is important to attain better outcome. <p> Objectives: We reviewed the diagnostic approach of septic shock in relation to the microcirculatory abnormalities, novel biomarkers, monitoring, interventions, and therapy. </p><p> Methods: A narrative literature review was carried out using PubMed, MEDLINE and Google scholar search engines. </p><p> Results: Septic shock is characte...</p>
Assessment of Possible Drug Interactions in Patients with Psoriasis and Associated Comorbid Medical Conditions: An Observational Study
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Background: Associated co-morbidities with psoriasis are treated with concomitant medications apart from the antipsoriatic therapy and the resulting Drug-Drug Interactions (DDI) may affect therapeutic outcome. < p> Objective: To assess the DDI in psoriatic patients with co-morbidities. </p><p> Method: In this prospective observational analysis, 150 prescriptions of psoriatic patients, receiving two or more drugs were analysed using drug interaction checker software. DDI was classified into minor, moderate, major and pharmacokinetic & pharmacodynamic. </p><p> Result: Of 150 pati...</p>
Applications of Nanocarbons in Bio-Medical Devices
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Carbon materials of either the nano-sizes or nano-structures are referred to nanocarbons, which from buckminsterfullerene (C<sub>60</sub>) discovered in 1985 to recent graphenes have attracted great attention of scientists and engineers in the wide fields of science and technology. Here we briefly describe nanocarbons such as graphene and carbon nanotubes (CNTs) including carbon nanofibers (CNFs) and carbon nanohorns (CNHs) with highlights on the emergence of their applications in bio-medical devices. http://ift.tt/29uzHvO
A Prioritization Method for Identifying Disease-Causative Gene Based on Hyper Graph Network
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Backgrounds: Difficulty on identification of transcription factor binding site lies in, compared with those hundreds or thousands bp background noise sequences, the motif signals with ten to several tens bp in length are rather short; moreover, the motif instance of a transcription factor is likely to mutate partially. The TFBS identification has always been a challenge task. <p> Results: The experimental methods which are widely used in the study on transcription regulation, the databases that collect information on TFBS, the models that represent TFBS and the TFBS identifica...</p>
Association of Risk Factors, Antimicrobial Resistance Trends and Occurrence of blaTEM, bla SHV and blaCTX M in Escherichia coli Causing Bacteremia
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Purpose: Escherichia coli are the most frequent cause of gram negative bloodstream infection. This study was done to evaluate the association of risk factors, antimicrobial susceptibility pattern and detection of TEM, SHV and CTX M genes in the extended spectrum beta lactamase (ESBL) producing E.coli. <p> Materials and Methods: 11,133 blood samples were processed in BacT/Alert bottles. Bacteria grown were identified and antibiotic susceptibility patterns were studied using VITEK2 system. ESBL production was tested using phenotypic method, VITEK system and by PCR. Statistical p...</p>
Association of Apolipoprotein E (ApoE) Polymorphism with Alzheimer’s Disease in Chinese Population
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Apolipoprotein E (ApoE) plays a vital role in cholesterol metabolism and its allele polymorphisms have been associated with several diseases including Alzheimer’s disease (AD). There are few systematic studies on ApoE polymorphism and its association with AD in Chinese population. To examine this issue, participants included 4251 subjects and 404 AD patients with 390 healthy elderly residing in Chongqing city were genotyped. The results showed that the ε3 allele presented the highest frequency (82%), followed by ε4 (6.25%) and ε2 (11.75%) in general population. ε3/ε3 genotype carr... περισσότερα »
Data-driven Approach to Detect and Predict Adverse Drug Reactions
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 15 δευτερόλεπτα
Background: Many factors that directly or indirectly cause adverse drug reaction (ADRs) varying from pharmacological, immunological and genetic factors to ethnic, age, gender, social factors as well as drug and disease related ones. On the other hand, advanced methods of statistics, machine learning and data mining allow the users to more effectively analyze the data for descriptive and predictive purposes. The fast changes in this field make it difficult to follow the research progress and context on ADR detection and prediction. Methods: A large amount of articles on ADRs in the... περισσότερα »
Issue Information
http://ift.tt/29AwQpY
Home-based intervention aims to curb childhood tooth decay and obesity in the Bronx
More than one-third of Bronx residents are born outside of the United States. Often separated from family, challenged by language barriers, unfamiliar with health resources, and burdened by poverty, they are at high risk for health problems. And these risks extend to their young children. http://ift.tt/29INCBq
Psoriasis Patients Treated With Biologics and Methotrexate Have a Reduced Rate of Myocardial Infarction: A Collaborative Analysis Using International Cohorts
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
Psoriasis Patients Treated With Biologics and Methotrexate Have a Reduced Rate of Myocardial Infarction: A Collaborative Analysis Using International Cohorts: Psoriasis is a chronic inflammatory skin condition characterised by the formation of red scaly plaques on the skin. It is an autoimmune disease cause by the dysregulation of cytokines controlling the inflammatory pathways, a mechanism likely contributing to various comorbidities observed in patients with psoriasis. Cardiovascular disease is one comorbidity observed more frequently in the psoriasis patient population. Biologic... περισσότερα »
Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.* Allergol Int. 2015 Oct;64(4):379-81 Authors: Kaniwa N, Ueta M, Nakamura R, Okamoto-Uchida Y, Sugiyama E, Maekawa K, Takahashi Y, Furuya H, Yagami A, Matsukura S, Ikezawa Z, Matsunaga K, Sotozono C, Aihara M, Kinoshita S, Saito Y PMID: 26433536 [PubMed - indexed for MEDLINE] http://ift.tt/29MbX8m http://ift.tt/2a5kfqV
Free-breathing Sparse Sampling Cine MR Imaging with Iterative Reconstruction for the Assessment of Left Ventricular Function and Mass at 3.0 T.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Free-breathing Sparse Sampling Cine MR Imaging with Iterative Reconstruction for the Assessment of Left Ventricular Function and Mass at 3.0 T.* Radiology. 2016 Jul 11;:151002 Authors: Sudarski S, Henzler T, Haubenreisser H, Dösch C, Zenge MO, Schmidt M, Nadar MS, Borggrefe M, Schoenberg SO, Papavassiliu T Abstract Purpose To prospectively evaluate the accuracy of left ventricle (LV) analysis with a two-dimensional real-time cine true fast imaging with steady-state precession (trueFISP) magnetic resonance (MR) imaging sequence featuring sparse data sampling with iterative recons... περισσότερα »
Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation.* J Neural Eng. 2016 Jul 11;13(4):046023 Authors: Nguyen TA, DiGiovanna J, Cavuscens S, Ranieri M, Guinand N, van de Berg R, Carpaneto J, Kingma H, Guyot JP, Micera S, Fornos AP Abstract OBJECTIVE: The vestibular system provides essential information about balance and spatial orientation via the brain to other sensory and motor systems. Bilateral vestibular loss significantly reduces quality of life, but vestibular implants (VIs) have demonstrated poten... περισσότερα »
Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma.* Acta Otolaryngol. 2016 Aug;136(8):806-811 Authors: Tang D, Tang WJ, Shi XL, Li WP, Zhou H, Lu LM, Tao L Abstract CONCLUSION: Long (GT)n repeat polymorphisms in the heme oxygenase-1 (HO-1) gene promoter and decreased serum HO-1 levels are associated with a higher susceptibility to laryngeal squamous cell carcinoma (LSCC). OBJECTIVE: In this case-control study, the association of HO-1 microsatellite (GT)n repeat p... περισσότερα »
Affective brain-computer music interfacing.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Affective brain-computer music interfacing.* J Neural Eng. 2016 Jul 11;13(4):046022 Authors: Daly I, Williams D, Kirke A, Weaver J, Malik A, Hwang F, Miranda E, Nasuto SJ Abstract OBJECTIVE: We aim to develop and evaluate an affective brain-computer music interface (aBCMI) for modulating the affective states of its users. APPROACH: An aBCMI is constructed to detect a user's current affective state and attempt to modulate it in order to achieve specific objectives (for example, making the user calmer or happier) by playing music which is generated according to a specific affective... περισσότερα »
Pharyngeal constrictor muscle fatty change may contribute to obstructive sleep apnea-hypopnea syndrome: a prospective observational study.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Pharyngeal constrictor muscle fatty change may contribute to obstructive sleep apnea-hypopnea syndrome: a prospective observational study.* Acta Otolaryngol. 2016 Jul 11;:1-6 Authors: Shi L, Wang H, Wei L, Hong Z, Wang M, Wang Z Abstract CONCLUSIONS: Pharyngeal constrictor muscle injury and fatty changes may play important roles in the pathogenesis and progression of OSAHS. OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a respiratory disorder caused by upper airway obstruction during sleep. The primary objectives of this study were to determine the ultrastructural... περισσότερα »
Use of infliximab in toxic epidermal necrolysis: a still opened challenge.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
Related Articles *Use of infliximab in toxic epidermal necrolysis: a still opened challenge.* G Ital Dermatol Venereol. 2015 Aug;150(4):467-71 Authors: Ganzetti G, Campanati A, Simonetti O, Giuliodori K, Giangiacomi M, Lemme G, Offidani A Abstract Toxic epidermal necrolysis (TEN), also known as Lyell syndrome, is a potential life-threatening muco-cutaneous disease with important systemic implications. It affects the skin and mucous membranes, with involvement of more than 30% of body surface and it is mostly caused by drugs. Although the pathogenesis is not fully elucidated, it i... περισσότερα »
Synthesis and SAR studies of potent H(+)/K(+)-ATPase inhibitors of quinazolinone-Schiff's base analogues.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Synthesis and SAR studies of potent H(+)/K(+)-ATPase inhibitors of quinazolinone-Schiff's base analogues.* Bioorg Chem. 2016 Jul 5;68:1-8 Authors: Rakesh KP, Shantharam CS, Manukumar HM Abstract A series of quinazolinone derived Schiff base derivatives 7-36 were synthesized and characterized by analytical and spectroscopic techniques. The synthesized analogues were screened for their in vitro H(+)/K(+)-ATPase inhibition. Most of the compounds showed excellent activity, compared to that of omeprazole, a reference drug. In particular, hydroxy and methoxy derivatives 13-24 were the... περισσότερα »
2016: Reviewing for Radiology-Reporting Guidelines and Why We Use Them.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*2016: Reviewing for Radiology-Reporting Guidelines and Why We Use Them.* Radiology. 2016 Jul 11; Authors: Levine D, Kressel HY Abstract It is our hope that increased use and awareness of guideline criteria will allow for the manuscripts, at the time of submission, to be more complete and aid our reviewers in better understanding, and thus critiquing, the methodology and results of submissions they receive. Online supplemental material is available for this article. PMID: 27399329 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http... περισσότερα »
Piero Periti Review Article Award 2014.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Piero Periti Review Article Award 2014.* J Chemother. 2015 Jun;27(3):127 Authors: Chiappini E, Sollai S, Bonsignori F, Galli L, de Martino M Abstract BACKGROUND: Drug-resistant tuberculosis (DR-TB) is emerging as an increasing problem worldwide and no consensus has been reached about the management of children contacts of DR-TB cases. OBJECTIVE: To evaluate the role of post-exposure chemoprophylaxis in paediatric DR-TB contacts, focusing on literature findings and recommendations from existing international guidelines. METHODS: We conducted a literature search of the Cochrane Libr... περισσότερα »
Protective Effect of Low-Intensity Pulsed Ultrasound on Memory Impairment and Brain Damage in a Rat Model of Vascular Dementia.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Protective Effect of Low-Intensity Pulsed Ultrasound on Memory Impairment and Brain Damage in a Rat Model of Vascular Dementia.* Radiology. 2016 Jul 11;:160095 Authors: Huang SL, Chang CW, Lee YH, Yang FY Abstract Purpose To investigate the neuroprotective effects of low-intensity pulsed (LIP) ultrasound on memory impairment and central nervous system injury in a rat model of vascular dementia. Materials and Methods All animal experiments were approved by the animal care and use committee and adhered to experimental animal care guidelines. A 1.0-MHz focused ultrasound transducer... περισσότερα »
Free-breathing Sparse Sampling Cine MR Imaging with Iterative Reconstruction for the Assessment of Left Ventricular Function and Mass at 3.0 T.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Free-breathing Sparse Sampling Cine MR Imaging with Iterative Reconstruction for the Assessment of Left Ventricular Function and Mass at 3.0 T.* Radiology. 2016 Jul 11;:151002 Authors: Sudarski S, Henzler T, Haubenreisser H, Dösch C, Zenge MO, Schmidt M, Nadar MS, Borggrefe M, Schoenberg SO, Papavassiliu T Abstract Purpose To prospectively evaluate the accuracy of left ventricle (LV) analysis with a two-dimensional real-time cine true fast imaging with steady-state precession (trueFISP) magnetic resonance (MR) imaging sequence featuring sparse data sampling with iterative recons... περισσότερα »
Percutaneous CT-guided Radiofrequency Ablation for Lymph Node Oligometastases from Hepatocellular Carcinoma: A Propensity Score-matching Analysis.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Percutaneous CT-guided Radiofrequency Ablation for Lymph Node Oligometastases from Hepatocellular Carcinoma: A Propensity Score-matching Analysis.* Radiology. 2016 Jul 11;:151807 Authors: Pan T, Xie QK, Lv N, Li XS, Mu LW, Wu PH, Zhao M Abstract Purpose To assess the effectiveness and safety of percutaneous computed tomography (CT)-guided radiofrequency ablation (RFA) for lymph node (LN) oligometastases from hepatocellular carcinoma (HCC). Materials and Methods This retrospective study was approved by the institutional ethics committee, and all patients provided written informed... περισσότερα »
Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Characterization of pulse amplitude and pulse rate modulation for a human vestibular implant during acute electrical stimulation.* J Neural Eng. 2016 Jul 11;13(4):046023 Authors: Nguyen TA, DiGiovanna J, Cavuscens S, Ranieri M, Guinand N, van de Berg R, Carpaneto J, Kingma H, Guyot JP, Micera S, Fornos AP Abstract OBJECTIVE: The vestibular system provides essential information about balance and spatial orientation via the brain to other sensory and motor systems. Bilateral vestibular loss significantly reduces quality of life, but vestibular implants (VIs) have demonstrated poten... περισσότερα »
Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma.* Acta Otolaryngol. 2016 Aug;136(8):806-811 Authors: Tang D, Tang WJ, Shi XL, Li WP, Zhou H, Lu LM, Tao L Abstract CONCLUSION: Long (GT)n repeat polymorphisms in the heme oxygenase-1 (HO-1) gene promoter and decreased serum HO-1 levels are associated with a higher susceptibility to laryngeal squamous cell carcinoma (LSCC). OBJECTIVE: In this case-control study, the association of HO-1 microsatellite (GT)n repeat p... περισσότερα »
Affective brain-computer music interfacing.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Affective brain-computer music interfacing.* J Neural Eng. 2016 Jul 11;13(4):046022 Authors: Daly I, Williams D, Kirke A, Weaver J, Malik A, Hwang F, Miranda E, Nasuto SJ Abstract OBJECTIVE: We aim to develop and evaluate an affective brain-computer music interface (aBCMI) for modulating the affective states of its users. APPROACH: An aBCMI is constructed to detect a user's current affective state and attempt to modulate it in order to achieve specific objectives (for example, making the user calmer or happier) by playing music which is generated according to a specific affective... περισσότερα »
Pharyngeal constrictor muscle fatty change may contribute to obstructive sleep apnea-hypopnea syndrome: a prospective observational study.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Pharyngeal constrictor muscle fatty change may contribute to obstructive sleep apnea-hypopnea syndrome: a prospective observational study.* Acta Otolaryngol. 2016 Jul 11;:1-6 Authors: Shi L, Wang H, Wei L, Hong Z, Wang M, Wang Z Abstract CONCLUSIONS: Pharyngeal constrictor muscle injury and fatty changes may play important roles in the pathogenesis and progression of OSAHS. OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a respiratory disorder caused by upper airway obstruction during sleep. The primary objectives of this study were to determine the ultrastructural... περισσότερα »
Use of infliximab in toxic epidermal necrolysis: a still opened challenge.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
Related Articles *Use of infliximab in toxic epidermal necrolysis: a still opened challenge.* G Ital Dermatol Venereol. 2015 Aug;150(4):467-71 Authors: Ganzetti G, Campanati A, Simonetti O, Giuliodori K, Giangiacomi M, Lemme G, Offidani A Abstract Toxic epidermal necrolysis (TEN), also known as Lyell syndrome, is a potential life-threatening muco-cutaneous disease with important systemic implications. It affects the skin and mucous membranes, with involvement of more than 30% of body surface and it is mostly caused by drugs. Although the pathogenesis is not fully elucidated, it i... περισσότερα »
Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
[image: http:--linkinghub.elsevier.com-ihub-imag] [image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.* Allergol Int. 2015 Oct;64(4):379-81 Authors: Kaniwa N, Ueta M, Nakamura R, Okamoto-Uchida Y, Sugiyama E, Maekawa K, Takahashi Y, Furuya H, Yagami A, Matsukura S, Ikezawa Z, Matsunaga K, Sotozono C, Aihara M, Kinoshita S, Saito Y PMID: 26433536 [PubMed - indexed for MEDLINE] from Head and Neck on PubMed via xlomafota13 on Inoreader http... περισσότερα »
Synthesis and SAR studies of potent H(+)/K(+)-ATPase inhibitors of quinazolinone-Schiff's base analogues.
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 28 δευτερόλεπτα
*Synthesis and SAR studies of potent H(+)/K(+)-ATPase inhibitors of quinazolinone-Schiff's base analogues.* Bioorg Chem. 2016 Jul 5;68:1-8 Authors: Rakesh KP, Shantharam CS, Manukumar HM Abstract A series of quinazolinone derived Schiff base derivatives 7-36 were synthesized and characterized by analytical and spectroscopic techniques. The synthesized analogues were screened for their in vitro H(+)/K(+)-ATPase inhibition. Most of the compounds showed excellent activity, compared to that of omeprazole, a reference drug. In particular, hydroxy and methoxy derivatives 13-24 were the... περισσότερα »
Personalized and targeted therapy of esophageal squamous cell carcinoma: an update.
*Personalized and targeted therapy of esophageal squamous cell carcinoma: an update.* Ann N Y Acad Sci. 2016 Jul 11; Authors: Liu Y, Xiong Z, Beasley A, D'Amico T, Chen XL Abstract Esophageal squamous cell carcinoma (ESCC) is a deadly disease that requires extensive research. In this review, we update recent progress in the research area of targeted therapy for ESCC. SOX2 and its associated proteins (e.g., ΔNP63α), which regulate lineage survival of ESCC cells, are proposed as therapeutic targets. It is believed that targeting the lineage-survival mechanism may be more effective ... περισσότερα »
The effect of individual and neighborhood socioeconomic status on esophageal cancer survival in working-age patients in Taiwan.
*The effect of individual and neighborhood socioeconomic status on esophageal cancer survival in working-age patients in Taiwan.* Medicine (Baltimore). 2016 Jul;95(27):e4140 Authors: Wu CC, Chang CM, Hsu TW, Lee CH, Chen JH, Huang CY, Lee CC Abstract Esophageal cancer is the sixth leading cause of cancer mortality. More than 90% of patients with esophageal cancer in Taiwan have squamous cell carcinoma. Survival of such patients is related to socioeconomic status (SES). We studied the association between SES (individual and neighborhood) and the survival of working-age patients wit... περισσότερα »
Duodenal perforation and esophageal ischemia following transarterial chemoembolization for hepatocellular carcinoma: A case report.
*Duodenal perforation and esophageal ischemia following transarterial chemoembolization for hepatocellular carcinoma: A case report.* Medicine (Baltimore). 2016 Jul;95(27):e3987 Authors: Kim SI, Jin YJ, Cho SG, Shin WY, Kim JM, Lee JW Abstract Transarterial chemoembolization (TACE) is frequently used for treatment of unresectable hepatocellular carcinoma (HCC) and can also be used for case of liver metastases from rectal cancer. Although it is recognized as safe and effective treatment, various complications have been reported. However, post-TACE duodenal perforation with duodenal... περισσότερα »
Recent improvements in the management of esophageal anastomotic leak after surgery for cancer.
*Recent improvements in the management of esophageal anastomotic leak after surgery for cancer.* Eur J Surg Oncol. 2016 Jun 29; Authors: Messager M, Warlaumont M, Renaud F, Marin H, Branche J, Piessen G, Mariette C Abstract Anastomotic leakage following total gastrectomy or esophagectomy is a significant complication that considerably increases postoperative mortality. The location of the anastomosis together with the anatomy of the esophagus explains the severity of this complication. Surgical knowledge should include general and specific predictive factors of leakage to avoid ... περισσότερα »
Panitumumab added to docetaxel, cisplatin and fluoropyrimidine in oesophagogastric cancer: ATTAX3 phase II trial.
[image: http:--http://ift.tt/20aQI5S] Related Articles *Panitumumab added to docetaxel, cisplatin and fluoropyrimidine in oesophagogastric cancer: ATTAX3 phase II trial.* Br J Cancer. 2016 Mar 1;114(5):505-9 Authors: Tebbutt NC, Price TJ, Ferraro DA, Wong N, Veillard AS, Hall M, Sjoquist KM, Pavlakis N, Strickland A, Varma SC, Cooray P, Young R, Underhill C, Shannon JA, Ganju V, Gebski V Abstract BACKGROUND: This randomised phase II study evaluated the efficacy and safety of panitumumab added to docetaxel-based chemotherapy in advanced oesophagogastric cancer. METHODS: Patients w... περισσότερα »
A randomised controlled trial of six weeks of home enteral nutrition versus standard care after oesophagectomy or total gastrectomy for cancer: report on a pilot and feasibility study.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *A randomised controlled trial of six weeks of home enteral nutrition versus standard care after oesophagectomy or total gastrectomy for cancer: report on a pilot and feasibility study.* Trials. 2015;16:531 Authors: Bowrey DJ, Baker M, Halliday V, Thomas AL, Pulikottil-Jacob R, Smith K, Morris T, Ring A Abstract BACKGROUND: Poor nutrition in the first months after oesophago-gastric resection is a contributing factor to the reduced quality of life seen in these patients. The aim of this p... περισσότερα »
Cancers prevented in Australia in 2010 through the consumption of aspirin.
[image: http:--media.wiley.com-assets-7315-19-Wi] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Cancers prevented in Australia in 2010 through the consumption of aspirin.* Aust N Z J Public Health. 2015 Oct;39(5):414-7 Authors: Wilson LF, Green AC, Kendall BJ, Jordan SJ, Nagle CM, Bain CJ, Neale RE, Whiteman DC Abstract OBJECTIVES: To estimate the proportion and number of cancers in Australia in 2010 that may have been prevented from occurring due to daily use of aspirin in the population. METHODS: We calculated the Prevented Fraction (PF) of colorectal and oesophageal ... περισσότερα »
Value of Positive Lymph Node Ratio for Predicting Postoperative Distant Metastasis and Prognosis in Esophageal Squamous Cell Carcinoma.
[image: http:--misc.karger.com-LinkOutIcons-sk_n] Related Articles *Value of Positive Lymph Node Ratio for Predicting Postoperative Distant Metastasis and Prognosis in Esophageal Squamous Cell Carcinoma.* Oncol Res Treat. 2015;38(9):424-8 Authors: Huang J, Hu W, Pang L, Chen J, Yang H Abstract BACKGROUND: The aim of this study was to investigate the relationship between positive lymph node ratio (PLNR) and postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma (ESCC). PATIENTS AND METHODS: 167 ESCC patients with regional lymph node metastasis, who und... περισσότερα »
Carcinoma of the oesophagus, with multiple cutaneous metastases.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Carcinoma of the oesophagus, with multiple cutaneous metastases.* BMJ Case Rep. 2015;2015 Authors: Khurana R, Mishra H, Malhotra KP, Shukla S Abstract A 42-year-old woman was referred, for adjuvant treatment, by an oncosurgeon (outside our centre) after a transhiatal oesophagectomy and gastric pull-up for middle one-third squamous cell carcinoma of the oesophagus pT3N1M0. She underwent adjuvant chemoradiotherapy (CRT) to the tumour bed, regional nodes and scar. RT dose planned was 45 Gy in 25 fractions over 5 week... περισσότερα »
Occult cirrhosis diagnosed by transient elastography is a frequent and under-monitored clinical entity.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Occult cirrhosis diagnosed by transient elastography is a frequent and under-monitored clinical entity.* Liver Int. 2015 Oct;35(10):2285-93 Authors: Chen T, Wong R, Wong P, Rollet-Kurhajec KC, Alshaalan R, Deschenes M, Ghali P, Sebastiani G Abstract BACKGROUND & AIMS: Diagnosis of preclinical compensated cirrhosis (occult cirrhosis, OC) is challenging due to lack of clinical findings. We evaluated prevalence and outcomes of OC by transient elastography (TE, Fibroscan(®)). METHODS: Eight hundred and seventy-one pa... περισσότερα »
The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus.
Related Articles *The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus.* Acta Dermatovenerol Croat. 2014;22(2):97-102 Authors: Vučićević Boras V, Savage NW, Brailo V, Škrinjar I, Valter K, Alajbeg I, Dulčić N, Vidović Juras D Abstract Oral lichen planus (OLP) is an immunologically T cell-mediated disease caused by an unknown stimulus. Despite intensive investigation its pathogenesis still remains unknown. A few possible associations between OLP and certain diseases such as thyroid and malignant diseases as well as specific med... περισσότερα »
PD-1/PD-L1, Only a Piece of the Puzzle.
*PD-1/PD-L1, Only a Piece of the Puzzle.* Arch Pathol Lab Med. 2016 Jul 11; Authors: Miller RA, Miller TN, Cagle PT PMID: 27399213 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29M9Dy1 via IFTTT
Naissance of the Archives of Pathology & Laboratory Medicine: A Critical Analysis of the January 1926, Volume 1 Issue.
*Naissance of the Archives of Pathology & Laboratory Medicine: A Critical Analysis of the January 1926, Volume 1 Issue.* Arch Pathol Lab Med. 2016 Jul 11; Authors: Gal AA, Cagle PT PMID: 27399212 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29L7RzV via IFTTT
The Diagnostic Concordance of Whole Slide Imaging and Light Microscopy: A Systematic Review.
*The Diagnostic Concordance of Whole Slide Imaging and Light Microscopy: A Systematic Review.* Arch Pathol Lab Med. 2016 Jul 11; Authors: Goacher E, Randell R, Williams B, Treanor D Abstract CONTEXT: -Light microscopy (LM) is considered the reference standard for diagnosis in pathology. Whole slide imaging (WSI) generates digital images of cellular and tissue samples and offers multiple advantages compared with LM. Currently, WSI is not widely used for primary diagnosis. The lack of evidence regarding concordance between diagnoses rendered by WSI and LM is a significant barrier t... περισσότερα »
Ventriculitis from a pituitary prolactinoma: bacterial or chemical?
*Ventriculitis from a pituitary prolactinoma: bacterial or chemical?* Br J Neurosurg. 2016 Jul 11;:1-2 Authors: Jayasekera BA, Hall J, Pearce S, Jenkins AJ Abstract We report the case of a 70-year-old man presenting with pituitary apoplexy from a macroprolactinoma and ventriculitis. It was not possible to distinguish a bacterial or chemical origin, on the basis of his clinical presentation, laboratory studies and imaging, highlighting the importance of prompt imaging and attainment of CSF cultures, in making the diagnosis. PMID: 27400138 [PubMed - as supplied by publisher] from ... περισσότερα »
Estrogen receptor gene polymorphism in patients with degenerative lumbar scoliosis.
*Estrogen receptor gene polymorphism in patients with degenerative lumbar scoliosis.* Br J Neurosurg. 2016 Jul 11;:1-4 Authors: Park YS, Suh KT, Shin JK, Lee JS Abstract OBJECTIVE: To examine the association between development of degenerative lumbar scoliosis (DLS) and sex hormones. METHODS: We investigated the association between DLS and estrogen receptor alpha (ERα) gene polymorphisms in 184 patients with a diagnosis of DLS, by determining the presences of the Pvu II and Xba I polymorphisms, measuring bone mineral densities at the lumbar spine (LSBMD) and femoral neck (FNBMD),... περισσότερα »
Enhanced brainstem and cortical encoding of sound during synchronized movement.
*Enhanced brainstem and cortical encoding of sound during synchronized movement.* Neuroimage. 2016 Jul 7; Authors: Nozaradan S, Schönwiesner M, Caron-Desrochers L, Lehmann A Abstract Movement to a steady beat has been widely studied as a model of alignment of motor outputs on sensory inputs. However, how the encoding of sensory inputs is shaped during synchronized movements along the sensory pathway remains unknown. To investigate this, we simultaneously recorded brainstem and cortical electro-encephalographic activity while participants listened to periodic amplitude-modulated t... περισσότερα »
[Hypertrophic pachymeningitis secondary to IgG4-related disease: case report and review of the literature].
[image: http:--http://ift.tt/1SOLcQp] Related Articles *[Hypertrophic pachymeningitis secondary to IgG4-related disease: case report and review of the literature].* Rev Neurol. 2015 Oct 1;61(7):308-12 Authors: Rodríguez-Castro E, Fernández-Lebrero A, López-Dequidt IA, Rodríguez-Osorio X, López-González FJ, Suárez-Peñaranda JM, Arias M Abstract INTRODUCTION: Hypertrophic pachymeningitis is an infrequent disorder that produces focal or diffuse thickening of the dura mater. It can be idiopathic or secondary to infectious, autoimmune or neoplastic processes. The recently described 'I... περισσότερα »
Folate and neural tube defects: The role of supplements and food fortification.
*Folate and neural tube defects: The role of supplements and food fortification.* Paediatr Child Health. 2016 Apr;21(3):145-54 Authors: Ami N, Bernstein M, Boucher F, Rieder M, Parker L, Canadian Paediatric Society, Drug Therapy and Hazardous Substances Committee Abstract Periconceptional folic acid significantly reduces the risk of neural tube defects. It is difficult to achieve optimal levels of folate by diet alone, even with fortification of flour, especially because flour consumption in Canada is slightly decreasing. Intermittent concerns have been raised concerning possible... περισσότερα »
The Circulating Concentration and 24-h Urine Excretion of Magnesium Dose- and Time-Dependently Respond to Oral Magnesium Supplementation in a Meta-Analysis of Randomized Controlled Trials.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *The Circulating Concentration and 24-h Urine Excretion of Magnesium Dose- and Time-Dependently Respond to Oral Magnesium Supplementation in a Meta-Analysis of Randomized Controlled Trials.* J Nutr. 2016 Mar;146(3):595-602 Authors: Zhang X, Del Gobbo LC, Hruby A, Rosanoff A, He K, Dai Q, Costello RB, Zhang W, Song Y Abstract BACKGROUND: Accurate determination of Mg status is important for improving nutritional assessment and clinical risk stratification. OBJECTIVE: We aimed to quantify the overall responsiveness of... περισσότερα »
Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk.
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Weight Status and Alcohol Intake Modify the Association between Vitamin D and Breast Cancer Risk.* J Nutr. 2016 Mar;146(3):576-85 Authors: Deschasaux M, Souberbielle JC, Latino-Martel P, Sutton A, Charnaux N, Druesne-Pecollo N, Galan P, Hercberg S, Le Clerc S, Kesse-Guyot E, Ezzedine K, Touvier M Abstract BACKGROUND: Mechanistic hypotheses suggest that vitamin D may contribute to the prevention of breast cancer. However, epidemiologic evidence is inconsistent, suggesting a potential effect modification by individ... περισσότερα »
Microsurgical posterior cervical foraminotomy: a study of 181 cases.
*Microsurgical posterior cervical foraminotomy: a study of 181 cases.* Br J Neurosurg. 2016 Jul 11;:1-6 Authors: Kerry G, Hammer A, Ruedinger C, Ranaie G, Steiner HH Abstract BACKGROUND: An unsettled controversy over the appropriate surgical approach in cases of cervical radiculopathy caused by degenerative vertebrae and intervertebral discs is still present. The purpose of this study is to examine the efficacy of microsurgical posterior foraminotomy in the treatment of cervical radiculopathy and to find out whether the underlying pathology (soft disc herniation/spondylosis) is of... περισσότερα »
309 Middle Fossa Approach to Lateralized Pontine Cavernomas in Children.
*309 Middle Fossa Approach to Lateralized Pontine Cavernomas in Children.* Neurosurgery. 2016 Aug;63 Suppl 1, CLINICAL NEUROSURGERY:189 Authors: Calayag M, Hoshide R, Gonda DD, Meltzer HS, Fukushima T, Levy ML Abstract INTRODUCTION: Hemorrhagic cavernous malformations involving the lateral pontine region require complex surgical considerations to maximize complete resection of the cavernoma and associated hemorrhage while minimizing morbidity. We describe our experience through the middle fossa rhomboid approach in 8 children with cavernomas involving the pons, with lateralized he... περισσότερα »
201 Transnasal Endoscopic Approach for Pediatric Skull Base Tumors: A Case Series.
*201 Transnasal Endoscopic Approach for Pediatric Skull Base Tumors: A Case Series.* Neurosurgery. 2016 Aug;63 Suppl 1, CLINICAL NEUROSURGERY:179 Authors: Quon JL, Hwang PH, Edwards MS Abstract INTRODUCTION: Transnasal endoscopic transphenoidal approaches are an essential technique for the resection of skull base tumors in adults. Originally devised and most commonly used to treat pituitary adenomas, they have also been used for a variety of other pathologies. However, in the pediatric population, sellar and suprasellar lesions have historically involved a craniotomy. Transnasal ... περισσότερα »
171 Resurgery in Craniovertebral Junction Abnormalities.
*171 Resurgery in Craniovertebral Junction Abnormalities.* Neurosurgery. 2016 Aug;63 Suppl 1, CLINICAL NEUROSURGERY:168 Authors: Sindgikar PP, Das KK, Jaiswal AK, Sahu RN, Srivastava AK, Mehrotra A, Sardhara JC, Bhaisora KS, Behari S Abstract INTRODUCTION: Surgery for craniovertebral junction (CVJ) abnormalities like atlantoaxial dislocation (AAD) with or without basilar invagination (BI) and/or with or without associated Arnold-Chiari malformation (ACM) cause high cervical myelopathy. Occasionally, mechanical factors such as inadequate canal decompression, torticollis, and/or sco... περισσότερα »
Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma.
*Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma.* Acta Otolaryngol. 2016 Aug;136(8):806-811 Authors: Tang D, Tang WJ, Shi XL, Li WP, Zhou H, Lu LM, Tao L Abstract CONCLUSION: Long (GT)n repeat polymorphisms in the heme oxygenase-1 (HO-1) gene promoter and decreased serum HO-1 levels are associated with a higher susceptibility to laryngeal squamous cell carcinoma (LSCC). OBJECTIVE: In this case-control study, the association of HO-1 microsatellite (GT)n repeat p... περισσότερα »
Deglutition and respiratory patterns during sleep in the aged.
*Deglutition and respiratory patterns during sleep in the aged.* Acta Otolaryngol. 2016 Jul 11;:1-7 Authors: Sato K, Chitose SI, Sato K, Umeno H Abstract CONCLUSION: Deglutition was extremely infrequent and displayed unique patterns during sleep in the aged. OBJECTIVES: The deglutition and respiratory phase patterns during sleep in the healthy aged were investigated in this study. METHODS: Ten aged adults (average age = 71 years) were examined via time-matched digital recordings of polysomnography and surface electromyography of the muscles (thyrohyoid and suprahyoid muscles) relat... περισσότερα »
Pharyngeal constrictor muscle fatty change may contribute to obstructive sleep apnea-hypopnea syndrome: a prospective observational study.
*Pharyngeal constrictor muscle fatty change may contribute to obstructive sleep apnea-hypopnea syndrome: a prospective observational study.* Acta Otolaryngol. 2016 Jul 11;:1-6 Authors: Shi L, Wang H, Wei L, Hong Z, Wang M, Wang Z Abstract CONCLUSIONS: Pharyngeal constrictor muscle injury and fatty changes may play important roles in the pathogenesis and progression of OSAHS. OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a respiratory disorder caused by upper airway obstruction during sleep. The primary objectives of this study were to determine the ultrastructural... περισσότερα »
A polymorphism in human estrogen-related receptor beta (ESRRβ) predicts audiometric temporary threshold shift.
*A polymorphism in human estrogen-related receptor beta (ESRRβ) predicts audiometric temporary threshold shift.* Int J Audiol. 2016 Jul 11;:1-9 Authors: Bhatt I, Phillips S, Richter S, Tucker D, Lundgren K, Morehouse R, Henrich V Abstract OBJECTIVE: A non-synonymous single nucleotide polymorphism (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta (ESRRβ) showed possible association to noise-induced hearing loss (NIHL) in our previous study. DESIGN: This study was conducted to examine the effect of the ESRRβ rs61742642 T variant on tem... περισσότερα »
Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material.
*Antibacterial chitosan/silk sericin 3D porous scaffolds as a wound dressing material.* Artif Cells Nanomed Biotechnol. 2016 Jul 9;:1-14 Authors: Karahaliloglu Z, Kilicay E, Denkbas EB Abstract Antimicrobial mixed dressings have traditionally been used to minimize bacterial infection of burns and other wounds. This study presents the advancement of biocompatible chitosan/silk sericin (CHT/SS) scaffolds combined with lauric acid (LA) and zinc oxide nanoparticles (nZnO) for the successful wound dressing applications. Antibacterial assay results showed that the diameters of the inhi... περισσότερα »
Low-cost and eco-friendly green synthesis of silver nanoparticles using Prunus japonica (Rosaceae) leaf extract and their antibacterial, antioxidant properties.
*Low-cost and eco-friendly green synthesis of silver nanoparticles using Prunus japonica (Rosaceae) leaf extract and their antibacterial, antioxidant properties.* Artif Cells Nanomed Biotechnol. 2016 Jul 9;:1-7 Authors: Saravanakumar A, Peng MM, Ganesh M, Jayaprakash J, Mohankumar M, Jang HT Abstract Low cost and eco-friendly green synthesis of silver nanoparticles (AgNPs) from silver nitrate (AgNO3) using Prunus japonica leaves extract as reducing agent by a simple method at room temperature. The biosynthesized nanoparticles (NPs) were characterized by UV-Vis, tunneling electron... περισσότερα »
[The importance of human response and collaboration problems in radioactive iodine treatment].
*[The importance of human response and collaboration problems in radioactive iodine treatment].* Enferm Clin. 2016 Jul 5; Authors: Alconero-Camarero AR, Íbañez-Rementería MI PMID: 27396232 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29Agyh4 via IFTTT
PHD1 regulates p53-mediated colorectal cancer chemoresistance.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *PHD1 regulates p53-mediated colorectal cancer chemoresistance.* EMBO Mol Med. 2015 Oct;7(10):1350-65 Authors: Deschoemaeker S, Di Conza G, Lilla S, Martín-Pérez R, Mennerich D, Boon L, Hendrikx S, Maddocks OD, Marx C, Radhakrishnan P, Prenen H, Schneider M, Myllyharju J, Kietzmann T, Vousden KH, Zanivan S, Mazzone M Abstract Overcoming resistance to chemotherapy is a major challenge in colorectal cancer (CRC) treatment, especially since the underlying molecular mechanisms rem... περισσότερα »
The strange connection between EGFR-TKIs and Dapsone: from the rash mitigation to the increase of anti-tumour activity.
*The strange connection between EGFR-TKIs and Dapsone: from the rash mitigation to the increase of anti-tumour activity.* Curr Med Res Opin. 2016 Jul 11;:1-38 Authors: Boccellino M, Quagliuolo L, Alaia C, Grimaldi A, Addeo R, Nicoletti GF, Kast RE, Caraglia M Abstract The presence of an aberrantly activated epidermal growth factor receptor (EGFR) in many epithelial tumors, due to its overexpression, activating mutations, gene amplification and/or overexpression of receptor ligands, represent the fundamental basis underlying the use of EGFR-tyrosine kinase inhibitors (EGFR_TKIs). ... περισσότερα »
Investigation of combination therapy modes of bevacizumab and paclitaxel for NSCLC in vivo.
Related Articles *Investigation of combination therapy modes of bevacizumab and paclitaxel for NSCLC in vivo.* Pak J Pharm Sci. 2016 Mar;29(2 Suppl):695-9 Authors: Wang J, Shen H, Jiang Q, Shu Y Abstract To explore the optimized scheduling and mode of administration of bevacizumab combined with paclitaxel in vivo. Human lung cancer A549 cells was subcutaneously injected in to 40 nude mice, which were stochastically divided into five groups: group A, physiological saline as control group, group B, paclitaxel 10 mg/kg/d, i.v.bolus, q5d×4; group C, paclitaxel (10 mg/kg/d) 24 hours ... περισσότερα »
The effects of respiratory sinus arrhythmia on anger reactivity and persistence in major depression
Abstract The experience of anger during a depressive episode has recently been identified as a poor prognostic indicator of illness course. Given the clinical implications of anger in major depressive disorder (MDD), understanding the mechanisms involved in anger reactivity and persistence is critical for improved intervention. Biological processes involved in emotion regulation during stress, such as respiratory sinus arrhythmia (RSA), may play a role in maintaining negative moods. Clinically depressed (MDD; *n* = 49) and nondepressed (non-MDD; *n* = 50) individuals were challenge... περισσότερα »
Examining habituation of the startle reflex with the reinforcement sensitivity theory of personality
Abstract The habituation of the acoustic startle reflex (ASR) was examined concerning individual differences in sensitivity to punishment (PUN) and sensitivity to reward (REW), within the general framework of the reinforcement sensitivity theory (RST) of personality. Two hypotheses derived from the RST were evaluated: the separable subsystems hypothesis and the joint subsystems hypothesis. In addition, we examined the direction of the relationship of PUN and REW with the habituation of the ASR. A habituation segment of electromyography recordings of the orbicularis oculi was assess... περισσότερα »
Sleep Disorders
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Sleep Disorders *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Internet Explorer and other programs. Learn more about feeds. [image: Plus Button]Subscribe to this feed [image: Feed image] Personalized Treatment of Obsessive-Com... περισσότερα »
Sagittal sinus thrombosis (SST) induced by chemotherapy
[image: http:--www.eurekaselect.com-sites-all-th] [image: http:--www.eurekaselect.com-sites-all-th] Curr Drug Saf. Authors: Kridis WB, Khanfir A, Kammoun F, Mahfoudh KB, Triki C, Frikha M Abstract Sagittal sinus thrombosis (SST) induced by chemotherapy is exceptional. We describe here a new case following the fourth cure of chemotherapy based on cisplatin, bleomycin and etoposide in a 16-year-old patient with no obvious risk factors. Through this uncommon case which forms part of cerebral venous sinus thrombosis (CVST), we propose to study the pathophysiology, the diagnosis and... περισσότερα »
Rare emerging malignant skin tumours : epithelial tumors (squamous cell carcinoma with mucinous metaplasia), adnexal tumors (endocrine mucin-producing sweat gland carcinoma), soft tissue tumors of vascular differentiation (pseudolymphomatous cutaneous angiosarcoma, pseudomyogenic hemangioendothelioma), hematopoietic tumors (blastic plasmacytoid dendritic cell neoplasm) and mixed epithelial/melanocytic tumor (squamomelanocytic tumor).
Rare emerging malignant skin tumours.: G Ital Dermatol Venereol. Authors: Rongioletti F, Ferreli C, Pinna AL, Atzori L Abstract As clinical skills improve and innovative diagnostic techniques become available in the field of dermatology and dermatopathology, new types or additional variants of malignant skin tumors are described. This article reviews the current nomenclature, clinico-pathological features, differential diagnosis, prognostic and therapeutic implications of some new dermato(patho)logical rare emerging skin tumors, including epithelial tumors (squamous cell carcinoma... περισσότερα »
Merkel cell carcinoma: a review.
Merkel cell carcinoma: a review G Ital Dermatol Venereol. Authors: Verzì AE, Amin SM, Guitart J, Micali G Abstract Merkel cell carcinoma (MCC) is a rare aggressive primary cutaneous carcinoma with high mortality and rising incidence. The exact etiology of MCC remains unclear, but it is likely multifactorial with many factors playing a role, among these, ultraviolet radiation, immunosuppression, and recently, Merkel cell polyomavirus. Clinically MCC appears as an asymptomatic, firm, skin colored, sometimes reddish-blue, dome-shaped papule or plaque or subcutaneous nodule typically ... περισσότερα »
Ischemic stroke in patients with gliomas
[image: http:--production.springer.de-OnlineReso] *Ischemic stroke in patients with gliomas at The University of Texas-M.D. Anderson Cancer Center.* Authors: Kamiya-Matsuoka C, Cachia D, Yust-Katz S, Rodriguez YA, Garciarena P, Rodarte EM, Tremont-Lukats IW Abstract Patients with gliomas are at risk of cerebrovascular accidents (CVA) with potential consequences on survival, function, and local tumor control. Our objective was to provide information about CVA in patients with gliomas and to estimate survival in this group. We reviewed all adult glioma patients with ischemic CVA a... περισσότερα »
Carotid aneurysm as a differential diagnosis of a cervical tumor
[image: http:--production.springer.de-OnlineReso] Authors: Engelhardt M, Elias K, Lorenz K, Maier H Abstract This article presents the case of a patient with a submandibular cervical tumor initially suspected to be a large lymph node or glomus tumor. However, the diagnostic workup prior to taking a biopsy sample revealed an extracranial aneurysm of the internal carotid artery. In order to prevent a permanent neurologic deficit arising from thromboembolism, the aneurysm was excluded by resection and arterial continuity was restored. Extracranial aneurysms of the internal carotid ... περισσότερα »
A systematic review of cognitive performance in patients with childhood craniopharyngioma.
[image: http:--production.springer.de-OnlineReso] Authors: Özyurt J, Müller HL, Thiel CM Abstract Craniopharyngiomas are rare brain tumors of the sellar/suprasellar region, often adversely affecting patients' physical and psychosocial functioning. Until a few years ago, knowledge on cognitive deficits in craniopharyngioma patients was based on little valid evidence, with considerable inconsistencies across studies. Findings from recent research, with partly larger sample sizes, add to existing evidence to provide a more clear and reliable picture. The current review aims to summ... περισσότερα »
Solitary spinal epidural cavernous haemangiomas as a rare cause of myelopathy.
[image: http:--highwire.stanford.edu-icons-exter] Authors: Meng Y, Shamji MF Abstract Cavernous haemangiomas rarely occur in the spinal epidural space. We report the case of a 27-year-old man who presented with myelopathy secondary to spinal cord compression from a purely epidural lesion. The imaging characteristics of cavernous haemangiomas are unique, reflecting a highly vascular lesion. Key differentiating features from intracranial or intramedullary lesions include the lack of a surrounding hemosiderin ring and popcorn appearance. An urgent referral to a neurosurgeon is reco... περισσότερα »
Osteoblastoma of the coracoid processs of the scapula : an unusual location.
[image: http:--highwire.stanford.edu-icons-exter] Authors: Arockiaraj J, Balaji G G, Vidyasagar B, Ashok A Abstract Bone tumours arising from the coracoid process of the scapula are very rare. We present a case of a 19-year-old man with left shoulder pain for 1 year, with associated infraclavicular swelling for 8 months. Examination revealed a tender, bony, hard swelling measuring 3×4 cm. Imaging revealed an expansile osteolytic lesion arising from the coracoid process with loss of corticomedullary differentiation. MRI showed altered signal in the adjacent soft tissues. The pat... περισσότερα »
Usefulness of Photodynamic Therapy as a Possible Therapeutic Alternative in the Treatment of Basal Cell Carcinoma.
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Savoia P, Deboli T, Previgliano A, Broganelli P Abstract Basal cell carcinoma (BCC) is the most common cancer in individuals with fair skin type (I-II) and steadily increasing in incidence (70% of skin malignancy). It is locally invasive but metastasis is usually very rare, with an estimated incidence of 0.0028%-0.55%. Conventional therapy is surgery, especially for the H region of the face and infiltrative lesions; in case of inoperable tumors, radiotherapy is a valid option. Recently, topical photodynamic therapy (PDT... περισσότερα »
Splenic abcess is an uncommon complication for cancer treatment
[image: http:--www.biomedcentral.com-graphics-pu] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Ismail E, El Barni R, Lahkim M, Rokhsi R, Atmane E, El Fikri A, Bouchama R, Achour A, Zyani M Abstract BACKGROUND: Splenic abcess is an uncommon complication for cancer treatment. It occurs more frequently in immunocompromised patients. They are characterized by high mortality. The classic triad (fever, pain of the left hypochondrium, and sensitive mass left) is only present in one-third of cases the clinical spectrum ranging from no symptoms to events such as fever, nau... περισσότερα »
Patterns of Chromosomal Aberrations in Solid Tumors.
[image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Grade M, Difilippantonio MJ, Camps J Abstract Chromosomal abnormalities are a defining feature of solid tumors. Such cytogenetic alterations are mainly classified into structural chromosomal aberrations and copy number alterations, giving rise to aneuploid karyotypes. The increasing detection of these genetic changes allowed the description of specific tumor entities and the associated patterns of gene expression. In fact, tumor-specific landscapes of gross genomic copy number changes, including aneuploidies of entire ch... περισσότερα »
Thyroid C-Cell Biology and Oncogenic Transformation.
Thyroid C-Cell Biology and Oncogenic Transformation.: Recent Results Cancer Res. Authors: Cote GJ, Grubbs EG, Hofmann MC Abstract The thyroid parafollicular cell, or commonly named "C-cell," functions in serum calcium homeostasis. Elevations in serum calcium trigger release of calcitonin from the C-cell, which in turn functions to inhibit absorption of calcium by the intestine, resorption of bone by the osteoclast, and reabsorption of calcium by renal tubular cells. Oncogenic transformation of the thyroid C-cell is thought to progress through a hyperplastic process prior to malign... περισσότερα »
Histopathology of C Cells and Medullary Thyroid Carcinoma.
Histopathology of C Cells and Medullary Thyroid Carcinoma Recent Results Cancer Res. Authors: Schmid KW Abstract The human thyroid gland contains less than 0.01-0.1% calcitonin producing and secreting C cells, which in men are almost exclusively situated in an intrafollicular location; the vast majority of C cells are embryologically derived of remnants of the ultimobranchial body and ultimately of the neural crest, a small subset, however, is presumed to originate from endodermal stem cells. Thyroid tumours with C cell differentiation have been named medullary thyroid carcinoma (... περισσότερα »
Epidemiology and Clinical Presentation of Medullary Thyroid Carcinoma.
Epidemiology and Clinical Presentation of Medullary Thyroid Carcinoma Recent Results Cancer Res. Authors: Raue F, Frank-Raue K Abstract Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from the thyroid C cells producing mainly calcitonin (CTN) used as tumor marker. MTC occurs either sporadic (75%) or in a hereditary form (multiple endocrine neoplasia type 2, MEN2), due to germline mutations in the RET proto-oncogene. The discovery of an MTC in a patient has several diagnostic implications involving a specific strategy: preoperative evaluation of the tum... περισσότερα »
Medullary Thyroid Carcinoma: Imaging.
Medullary Thyroid Carcinoma: Imaging.: Recent Results Cancer Res. Authors: Delorme S, Raue F Abstract Imaging plays an important role in early detection and staging of medullary thyroid carcinoma (MTC) as well as in follow-up to localize early recurrence. MTC is a rare, calcitonin-secreting thyroid malignancy often diagnosed by ultrasound and calcitonin screening as part of the routine workup for any thyroid nodule. If calcitonin is elevated, imaging studies are needed for preoperative staging, which dictates surgical management. This can be done by ultrasound of the neck and abdo... περισσότερα »
Calcitonin as Biomarker for the Medullary Thyroid Carcinoma.C-cell hyperplasia (CCH).The measurement of CTN concentrations in blood reflects C-cell activity
Calcitonin as Biomarker for the Medullary Thyroid Carcinoma.: Recent Results Cancer Res. Authors: Bae YJ, Schaab M, Kratzsch J Abstract Calcitonin (CTN) is a polypeptide hormone consisting of 32 amino acids with a disulfide bridge between position 1 and 7 that is mainly produced by the C-cells of thyroid gland. The measurement of CTN concentrations in blood reflects C-cell activity and is performed in general by immunoassay methods. However, there are analytical, physiological, pharmacological, and pathological factors that can influence results of serum CTN values. Due to the inf... περισσότερα »
Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.
Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation Recent Results Cancer Res. Authors: Frank-Raue K, Raue F Abstract During the last two decades, there has been a marked expansion of our knowledge of both the basic and clinical aspects of multiple endocrine neoplasia type 2 (MEN2). There are two clinically distinct types of MEN2 syndrome, termed MEN2A and MEN2B. Within MEN2A, there are four variants: (i) classical MEN2A, represented by the uniform presence of MTC and the less frequent occurrence of pheochromocytoma, or primary hyperparathyroidism, or both; (ii) MEN... περισσότερα »
Pheochromocytomas in Multiple Endocrine Neoplasia Type 2.
Pheochromocytomas in Multiple Endocrine Neoplasia Type 2.: Recent Results Cancer Res. Authors: Tsang VH, Tacon LJ, Learoyd DL, Robinson BG Abstract Pheochromocytoma (PC) is a neuroendocrine tumor that originates from chromaffin cells of the adrenal medulla. The production of catecholamines, including epinephrine, norepinephrine and dopamine, may lead to haemodynamic instability. Over 30% of PCs are associated with germline mutations, including re-arranged in transfection (RET) mutations seen in multiple endocrine neoplasia type 2 (MEN2) syndromes. Around 40% of individuals with ME... περισσότερα »
Primary Hyperparathyroidism in MEN2 Syndromes.
Primary Hyperparathyroidism in MEN2 Syndromes.: Recent Results Cancer Res. Authors: Alevizaki M, Saltiki K Abstract One of the components of trethe classical form of MEN2 syndromes is primary hyperparathyroidism (PHP). It occurs in 20-30% of the typical MEN2A syndrome. The prevalence is more rare in gene carriers as these frequently have familial MTC only. PHP is diagnosed more frequently in association with the exon 11, codon 634 mutation of the ret gene-so there is phenotype/genotype correlation. The clinical manifestations of PHP in MEN2 are usually mild and the peak age of dia... περισσότερα »
Surgical Treatment of Medullary Thyroid Cancer.
Surgical Treatment of Medullary Thyroid Cancer Recent Results Cancer Res. Authors: Machens A, Dralle H Abstract Medullary thyroid cancer (MTC) can vary in tumor biology and progression. The most important indicator of distant metastases, determining clinical outcome, is lymph node metastasis to the neck and mediastinum. Surgical cure is within reach in node-negative tumors or node-positive tumors with fewer than 10 lymph node metastases. From a surgical point of view, compartment-oriented lymph node dissection, clearing gross, and occult metastases are important for locoregional t... περισσότερα »
Long-Term Follow-up in Medullary Thyroid Carcinoma.Palliative surgery, external beam radiation therapy (EBRT), or systemic therapy with tyrosine kinase inhibitor (TKI).
Long-Term Follow-up in Medullary Thyroid Carcinoma.: Recent Results Cancer Res. Authors: Raue F, Frank-Raue K Abstract After surgery, patients with medullary thyroid carcinoma (MTC) should be assessed regarding the presence of residual disease, the localization of metastases, and the identification of progressive disease. Postoperatively, patients with MTC are staged to separate those at low risk from those at high risk of recurrence. The TNM staging system is based on tumor size, extra-thyroidal invasion, nodal metastasis, and distant spread of cancer. In addition, the number of ... περισσότερα »
Use of Tyrosine Kinase Inhibitors for Treatment of Medullary Thyroid Carcinoma.
Use of Tyrosine Kinase Inhibitors for Treatment of Medullary Thyroid Carcinoma Recent Results Cancer Res. Authors: Dadu R, Hu MN, Grubbs EG, Gagel RF Abstract Two independent events--the identification of activating mutations of the RET proto-oncogene, a receptor tyrosine kinase, in medullary thyroid carcinoma, and the recognition that small organic molecules could bind to and inhibit phosphorylation of signaling molecules, thereby inactivating the pathway-led to the recognition that kinase inhibitors could be used to treat medullary thyroid carcinoma (MTC). The introduction of th... περισσότερα »
Diagnosis and Management of Hereditary Meningioma and Vestibular Schwannoma.
Diagnosis and Management of Hereditary Meningioma and Vestibular Schwannoma. : Recent Results Cancer Res. 2016;205:17-27 Authors: Shaw A Abstract Bilateral vestibular schwannomata and meningiomata are the tumours most commonly associated with neurofibromatosis type II (NF2). These tumours may also be seen in patients with schwannomatosis and familial meningioma, but these phenotypes are usually easy to distinguish. The main diagnostic challenge when managing these tumours is distinguishing between sporadic disease which carries low risk of subsequent tumours or NF2 with its associ... περισσότερα »
Medullary thyroid cancer (MTC) arises from the parafollicular cells of the thyroid which release calcitonin. The familial form of MTC accounts for 20-25% of cases and presents as a part of the multiple endocrine neoplasia type 2 (MEN 2) syndromes or as a pure familial MTC (FMTC).
Diagnosis and Management of Hereditary Thyroid Cancer Recent Results Cancer Res. 2016;205:29-44 Authors: Bano G, Hodgson S Abstract Thyroid cancers are largely divided into medullary (MTC) and non-medullary (NMTC) cancers , depending on the cell type of origin. Familial non-medullary thyroid cancer (FNMTC) comprises about 5-15% of NMTC and is a heterogeneous group of diseases, including both non-syndromic and syndromic forms. Non-syndromic FNMTC tends to manifest papillary thyroid carcinoma , usually multifocal and bilateral . Several high-penetrance genes for FNMTC have been ide... περισσότερα »
[Voice rehabilitation after total laryngectomy: A chronological review of medical history].
[image: http:--production.springer.de-OnlineReso] Related Articles *[Voice rehabilitation after total laryngectomy: A chronological review of medical history].* HNO. 2015 Oct;63(10):663-4, 666-80 Authors: Lorenz KJ Abstract BACKGROUND: Loss of voice is the consequence of laryngectomy most disturbing for the patient. As such, the notion of performing a laryngectomy has always been directly linked to the possibility of voice rehabilitation. The multitude of different technical and surgical approaches pays testimony to the problems associated with rehabilitation of speech and swall... περισσότερα »
Quantitative measurements in capsule endoscopy.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Quantitative measurements in capsule endoscopy.* Comput Biol Med. 2015 Oct 1;65:333-47 Authors: Keuchel M, Kurniawan N, Baltes P, Bandorski D, Koulaouzidis A Abstract This review summarizes several approaches for quantitative measurement in capsule endoscopy. Video capsule endoscopy (VCE) typically provides wireless imaging of small bowel. Currently, a variety of quantitative measurements are implemented in commercially available hardware/software. The majority is proprietary and hence undisclosed algorithms. Meas... περισσότερα »
313 Impact of Intraoperative Steroids on Postoperative Infection Rates and Length of Hospital Stay: A Study of 1200 Spine Surgery Patients.
*313 Impact of Intraoperative Steroids on Postoperative Infection Rates and Length of Hospital Stay: A Study of 1200 Spine Surgery Patients.* Neurosurgery. 2016 Aug;63 Suppl 1, CLINICAL NEUROSURGERY:190 Authors: Elsamadicy AA, Wang TY, Karikari IO, Gottfried ON Abstract INTRODUCTION: The effects and use of intraoperative steroids is relatively unknown and remains controversial. There have been conflicting studies demonstrating the efficacy of intraoperative steroids on postoperative dysphagia and inflammation, whereas others demonstrate no improvement in outcomes. The aim of this ... περισσότερα »
312 Risk Factors and Clinical Outcomes of Dysphagia After Anterior Cervical Surgery in Patients With Degenerative Cervical Myelopathy: Results From the AOSpine International and North America Studies.
*312 Risk Factors and Clinical Outcomes of Dysphagia After Anterior Cervical Surgery in Patients With Degenerative Cervical Myelopathy: Results From the AOSpine International and North America Studies.* Neurosurgery. 2016 Aug;63 Suppl 1, CLINICAL NEUROSURGERY:190 Authors: Tetreault L, Nagoshi N, Nakashima H, Arnold PM, Barbagallo G, Kopjar B, Fehlings MG Abstract INTRODUCTION: The objective of this study is to determine the incidence and risk factors of postoperative dysphagia and to evaluate short- and long-term clinical outcomes in patients with this complication. METHODS: Four ... περισσότερα »
160 Outpatient Surgery for Herniated Cervical Disc and Fusion Is Feasible and Safe: A Consecutive Single-Center Series of 759 Patients.
*160 Outpatient Surgery for Herniated Cervical Disc and Fusion Is Feasible and Safe: A Consecutive Single-Center Series of 759 Patients.* Neurosurgery. 2016 Aug;63 Suppl 1, CLINICAL NEUROSURGERY:164 Authors: Lied B, Helseth O, Ekseth K, Heskestad B, Helseth E Abstract INTRODUCTION: There is an increasing demand for surgery of degenerative spinal disease. Limited health care resources draw attention to the need for cost-effective treatments. Outpatient surgery, when safe and feasible, is more cost-effective than inpatient surgery. The aim of this study is to study types and rates o... περισσότερα »
Neurorehabilitation strategies for poststroke oropharyngeal dysphagia: from compensation to the recovery of swallowing function.
*Neurorehabilitation strategies for poststroke oropharyngeal dysphagia: from compensation to the recovery of swallowing function.* Ann N Y Acad Sci. 2016 Jul 11; Authors: Cabib C, Ortega O, Kumru H, Palomeras E, Vilardell N, Alvarez-Berdugo D, Muriana D, Rofes L, Terré R, Mearin F, Clavé P Abstract Oropharyngeal dysphagia (OD) is very prevalent among poststroke patients, causing severe complications but lacking specific neurorehabilitation treatment. This review covers advances in the pathophysiology, diagnosis, and physiologically based neurorehabilitation strategies for poststro... περισσότερα »
Most 30-day Readmissions After Anterior Cervical Discectomy and Fusion are Not Due to Surgical Site-Related Issues: An Analysis of 17,088 Patients.
*Most 30-day Readmissions After Anterior Cervical Discectomy and Fusion are Not Due to Surgical Site-Related Issues: An Analysis of 17,088 Patients.* Spine (Phila Pa 1976). 2016 Jul 7; Authors: Samuel AM, Fu MC, Toy JO, Lukasiewicz AM, Webb ML, Bohl DD, Basques BA, Albert TJ, Grauer JN Abstract STUDY DESIGN: A retrospective study of patients undergoing anterior cervical discectomy and fusion (ACDF) in the prospective National Surgical Quality Improvement Program (NSQIP) database. OBJECTIVE: To determine the most common reasons for readmission within 30 days after elective ACDF. SU... περισσότερα »
Gastrointestinal and nutritional problems in neurologically impaired children.
*Gastrointestinal and nutritional problems in neurologically impaired children.* Eur J Paediatr Neurol. 2016 Jun 11; Authors: Quitadamo P, Thapar N, Staiano A, Borrelli O Abstract The current increasing survival of children with severe central nervous system damage has created a major challenge for medical care. Gastrointestinal and nutritional problems in neurologically impaired children have been recently recognized as an integral part of their disease, often leading to growth failure and worsened quality of life for both children and caregivers. Nutritional support is essentia... περισσότερα »
Treating and preventing dysphagia in the community.
*Treating and preventing dysphagia in the community.* Br J Community Nurs. 2016 Jul;21(Sup7):S10-S13 Authors: Thompson R PMID: 27396859 [PubMed - as supplied by publisher] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/2a5aXei via IFTTT
Acute opercular syndrome in 4-year-old boy.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *Acute opercular syndrome in 4-year-old boy.* Neurol Neurochir Pol. 2016;50(3):185-9 Authors: Pniewska A, Pawłowska M Abstract Acute opercular syndrome is a rare described syndrome caused by a sudden damage of the cerebral cortex and subcortical white matter, located around the insula. A rare cause of this syndrome can be an infectious agent, particularly herpes simplex virus. Quick diagnosis and immediate initiation of treatment significantly reduce the risk of neurological consequences and mortality. We present ... περισσότερα »
Psychological distress and health-related quality of life among head and neck cancer patients during the first year after treatment.
[image: http:--http://ift.tt/1SLHBms] Related Articles *Psychological distress and health-related quality of life among head and neck cancer patients during the first year after treatment.* Tumori. 2016 Jan-Feb;102(1):96-102 Authors: Ninu MB, Miccinesi G, Bulli F, De Massimi A, Muraca MG, Franchi G, Squadrelli Saraceno M Abstract PURPOSE: Patients treated for head and neck cancer present some of the most significant posttreatment morbidity of any group of patients with cancer. Our aim is to describe quality of life and psychological distress after different treatments among head ... περισσότερα »
[Foix-Chavany-Marie syndrome presenting as multiple sclerosis].
[image: http:--http://ift.tt/1SOLcQp] Related Articles *[Foix-Chavany-Marie syndrome presenting as multiple sclerosis].* Rev Neurol. 2015 Oct 1;61(7):332-3 Authors: Muñoz A, López-Méndez P, Hervás-García M, Ruano A, García-Rodríguez JR PMID: 26411278 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/29Aq6TK via IFTTT
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