The prognostic significance of faecal calprotectin in patients with inactive inflammatory bowel disease
Summary Background Faecal calprotectin, an established biomarker used to assess mucosal inflammation, has been shown to correlate with endoscopic activity in inflammatory bowel disease (IBD). Longitudinal monitoring of faecal calprotectin, however, has rarely been employed beyond assessment of therapy response and *post hoc* analyses of clinical trials. Aim To study whether consecutive measurements of faecal calprotectin every third month are useful for monitoring patients with IBD in clinical remission. Methods Patients aged 18 years or older, with a known diagnosis of IBD in ... περισσότερα »
Fatigue: a distressing symptom for patients with irritable bowel syndrome
Abstract Background Fatigue is a frequent symptom in patients with irritable bowel syndrome (IBS), and is associated with poor quality of life. However, few studies have evaluated its impact on daily life or the perceived distress it can cause. Using a multi-methods approach, this study describes the impact and manifestations of fatigue in patients with IBS and investigates the relationship between fatigue severity and illness-related and health-promoting factors. Methods A total of 160 patients with IBS completed self-reported questionnaires assessing fatigue, gastrointestinal ... περισσότερα »
Anaplastic astrocytoma: prognostic factors and survival in 4807 patients with emphasis on receipt and impact of adjuvant therapy
Abstract To determine the receipt and impact of adjuvant therapy on overall survival (OS) for anaplastic astrocytoma (AA). Data were extracted from the National Cancer Data Base (NCDB). Chi square test, Kaplan–Meier method, and Cox regression models were employed in SPSS 22.0 (Armonk, NY: IBM Corp.) for data analyses. 4807 patients with AA diagnosed from 2004 to 2013 who underwent surgery were identified. 3243 (67.5 %) received adjuvant chemoRT, 525 (10.9 %) adjuvant radiotherapy (RT) alone, 176 (3.7 %) adjuvant chemotherapy alone and 863 (18.0 %) received no adjuvant therapy. Pati... περισσότερα »
YPEL3 suppresses epithelial–mesenchymal transition and metastasis of nasopharyngeal carcinoma cells through the Wnt/β-catenin signaling pathway
Metastasis remains the major cause of death in nasopharyngeal carcinoma (NPC). Yippee-like 3 (YPEL3) plays an important role in tumorigenesis. However, its function and mechanism in NPC has not been systematic... from Cancer via ola Kala on Inoreader http://ift.tt/29zPlee via IFTTT
Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Tatsuro Watanabe, Patricia Ernst In this issue of Cancer Cell, Stavropoulou et al. report that expression of the MLL-AF9 fusion results in acute myelogenous leukemia (AML) with different behaviors depending on cell context, which leads them to identify a transcriptional signature surprisingly resembling that of the epithelial-to-mesenchymal (EMT) transition, correlating with aggressiveness of disease. Teaser In this issue of Cancer Cell, Stavropoulou et al. report that expression of the MLL-AF9 fusion... περισσότερα »
Antagonizing Self-Renewal in Acute Myeloid Leukemia: ID2 Takes the Stage
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Gauri Deb, Tim C.P. Somervaille E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghisi et al. show that high ID2 levels antagonize self-renewal and promote differentiation of leukemic stem cells in the MLL-translocated molecular subtype of acute myeloid leukemia. Teaser E proteins and their functional antagonists, the ID proteins, have significant roles in normal hematopoiesis. In this issue of Cancer Cell, Ghis... περισσότερα »
RIPK3 Slams the Brake on Leukemogenesis
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Francis Ka-Ming Chan Evasion of cell death is a key hallmark of cancers. In this issue of Cancer Cell, Höckendorf and colleagues identified RIPK3, an essential kinase for necroptosis, as having a key role in inhibiting acute myeloid leukemia development. Teaser Evasion of cell death is a key hallmark of cancers. In this issue of Cancer Cell, Höckendorf and colleagues identified RIPK3, an essential kinase for necroptosis, as having a key role in inhibiting acute myeloid leukemia development. from Can... περισσότερα »
Modeling the Epigenetic Chain Reaction Downstream of DNMT3AR882H
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Tim D.D. Somerville, Christopher R. Vakoc In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3AR882H /NRASG12D acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound enhancers to initiate disease. The authors also reveal a chemical strategy to interrupt this process. Teaser In this issue of Cancer Cell, Lu et al. use a mouse model of DNMT3A R882H/NRASG12D acute myeloid leukemia to define a cascade of chromatin changes that emanate from DNMT3A-bound en... περισσότερα »
Treatment of opioid use disorder in an innovative community-based setting after multiple treatment attempts in a woman with untreated HIV
Opioid use disorder is associated with significant health and social harms. Various evidence-based interventions have proven successful in mitigating these harms, including harm reduction strategies and pharmacological treatment such as methadone. We present a case of a 35-year-old HIV-positive woman who was off antiretroviral therapy due to untreated opioid use disorder, and had a history of frequently self-discharging from hospital against medical advice. During the most recent hospital admission, the patient was transferred to an innovative community-based clinical support resi... περισσότερα »
Birth brachial plexus palsy: a race against time
A 5-year-old child presented to us with weakness of the left upper limb since birth. With the given history of obstetric trauma and limb examination, a diagnosis of birth brachial plexus palsy was made. Brachial plexus exploration along with microsurgery was performed at the same time which included extrinsic neurolysis of the roots and trunks and nerve transfer for better shoulder external rotation and elbow flexion. Both the movements were severely restricted previously due to co-contractures with the shoulder internal rotators and triceps. The problem of birth brachial plexus p... περισσότερα »
Left atrial myxoma complicated by acute embolism to the left subclavian artery
Description A 65-year-old man presented with acute-onset pain and numbness in the left upper limb for the past 6 hours. On examination, the left upper limb was pale and cold with absent pulses. There was no neurological deficit. The patient was a non-smoker, and had no atherosclerotic risk factors. Cardiac auscultation was normal. Subclavian artery angiography showed multiple filling defects in the proximal segment and total occlusion just after the origin of the vertebral artery (figure 1 and video 1). Transthoracic echocardiogram was carried out to assess a possible cardiac sou... περισσότερα »
In vivo early retinal structural alterations following laser photocoagulation using three-dimensional spectral domain optical coherence tomography
To study the retinal structural alterations and surface topography of retinal pigment epithelium (RPE) immediately following laser photocoagulation up to day 7. Cross-sectional retinal imaging and RPE segmentation maps on spectral domain optical coherence tomography were obtained immediately at hour 1, day 1, day 4 and day 7 following 532 nm neodymium:YAG laser photocoagulation in a 56-year-old male patient for branch retinal vein occlusion. Immediately postlaser, loss of reflectivity of all the retinal layers was observed. At hour 1, hyper-reflectivity of outer retinal layers was... περισσότερα »
Barraquer-Simons syndrome: a unique patient's perspective on diagnosis, disease progression and recontouring treatment
This case report describes a female patient diagnosed with Barraquer-Simons syndrome, a rare form of acquired partial lipodystrophy characterised by symmetrical loss of adipose tissue from face, neck, upper extremities and the trunk with onset in early childhood. Initial symptoms were seen at the age of 8 years. Our patient did not show signs of renal impairment and this may be associated with the syndrome. Treatment of lipoatrophy in these patients is limited to cosmetic restoration, and autologous fat grafting has shown sustained positive effects with no or very little loss of vo... περισσότερα »
Correction: Painful knees and hearing-loss: a rare presentation of meningococcal disease
Kahlmann V, Alves C, Coleman J, *et al*. Painful knees and hearing-loss: a rare presentation of meningococcal disease. *BMJ Case Reports* 2016; doi:10.1136/ bcr-2016-214583. There is an error in the author list of this article. The correct name for the third author is Johannes Koeleman. The updated citation is: Kahlmann V, Alves C, Koeleman J, *et al*. Painful knees and hearing-loss: a rare presentation of meningococcal disease. *BMJ Case Reports* 2016; doi:10.1136/ bcr-2016-214583. from Cases via ola Kala on Inoreader http://ift.tt/29AHPvw via IFTTT
Uterine incarceration in a primigravid retroverted bicornuate uterus
Uterine incarceration is a rare complication that usually occurs after the first trimester of pregnancy. It leads to increased maternal and/or fetal morbidity and mortality. Risk factors include retroversion of uterus and other pelvic abnormalities. Clinical presentation includes severe abdominal and pelvic pain symptoms. Patients can present with concurrent urinary symptoms due to increasing distortion of adjacent structures from the enlarging uterus. A high clinical suspicion of uterine incarceration is confirmed with ultrasound. More advanced imaging such as MRI can be used as ... περισσότερα »
Tumor-Associated Neutrophils Show Phenotypic and Functional Divergence in Human Lung Cancer
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Shilpi Saha, Subhra K. Biswas Studies in murine cancer models have demonstrated the phenotypic and functional divergence of neutrophils; however, their role in pro- or anti-tumor responses in human remains elusive. In this issue of Cancer Cell, Singhal et al. report the existence of specialized subsets of neutrophils in human lung cancer with diverging functions. Teaser Studies in murine cancer models have demonstrated the phenotypic and functional divergence of neutrophils; however, their role in pro-... περισσότερα »
Molecular Subtypes of Non-muscle Invasive Bladder Cancer
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Seth P. Lerner, A. Gordon Robertson In this issue of Cancer Cell, Hedegaard et al. report a comprehensive multi-center transcriptional analysis of non-muscle invasive urothelial bladder cancer. They describe three molecular subtypes similar to those seen in other cohorts, as well as a unique CIS signature associated with risk of progression to muscle invasive cancer. Teaser In this issue of Cancer Cell, Hedegaard et al. report a comprehensive multi-center transcriptional analysis of non-muscle invasive... περισσότερα »
Hunger Pains: Stimulating the Appetite of the Immune System for Cancer
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Judson M. Englert, Jonathan D. Powell In this issue, Pietrocola et al. and Di Biase et al. independently demonstrate that caloric restriction from fasting and pharmacologic inhibition results in an enhanced immunogenic response leading to reduced tumor growth. These two studies provide an exciting connection between the emerging fields of cancer and immune metabolism. Teaser In this issue, Pietrocola et al. and Di Biase et al. independently demonstrate that caloric restriction from fasting and pharmaco... περισσότερα »
P(URI)fying Novel Drivers of NASH and HCC: A Feedforward Loop of IL17A via White Adipose Tissue
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Achim Weber, Mathias Heikenwalder How obesity and metabolic syndrome trigger non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remains elusive. In this issue, Gomes and colleagues describe that nutrient surplus induces hepatic URI expression, triggering genotoxicity and IL17A expression, thus leading to insulin resistance, NASH, and HCC. IL17A signaling blockers might become a readily translatable therapy. Teaser How obesity and metabolic syndrome trigger non-alcoholic steatohepa... περισσότερα »
The Multifaceted Role of Perivascular Macrophages in Tumors
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Claire E. Lewis, Allison S. Harney, Jeffrey W. Pollard Evidence has emerged for macrophages in the perivascular niche of tumors regulating important processes like angiogenesis, various steps in the metastatic cascade, the recruitment and activity of other tumor-promoting leukocytes, and tumor responses to frontline therapies like irradiation and chemotherapy. Understanding the mechanisms controlling the recruitment, retention, and function of these cells could identify important targets for anti-canc... περισσότερα »
Validity of Self-Reported Medication Use Compared With Pharmacy Records in a Cohort of Older Women: Findings From the Women's Health Initiative
Inaccurate self-reported data on medication exposure lead to less reliable study findings. From 2013 to 2015, we assessed the validity of information on medication use collected via a mailed medication inventory among 223 Women's Health Initiative participants who were members of a health-care delivery system. Self-reported information on medication use was compared with pharmacy records for statins, calcium channel blockers, β-blockers, and bisphosphonates. We assessed sensitivity, specificity, and positive predictive value (PPV) for current medication use. We assessed agreement o... περισσότερα »
RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Ulrike Höckendorf, Monica Yabal, Tobias Herold, Enkhtsetseg Munkhbaatar, Stephanie Rott, Stefanie Jilg, Johanna Kauschinger, Giovanni Magnani, Florian Reisinger, Michael Heuser, Hans Kreipe, Karl Sotlar, Thomas Engleitner, Roland Rad, Wilko Weichert, Christian Peschel, Jürgen Ruland, Mathias Heikenwalder, Karsten Spiekermann, Julia Slotta-Huspenina, Olaf Groß, Philipp J. Jost Since acute myeloid leukemia (AML) is characterized by the blockade of hematopoietic differentiation and cell death, we interro... περισσότερα »
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Stefano Di Biase, Changhan Lee, Sebastian Brandhorst, Brianna Manes, Roberta Buono, Chia-Wei Cheng, Mafalda Cacciottolo, Alejandro Martin-Montalvo, Rafael de Cabo, Min Wei, Todd E. Morgan, Valter D. Longo Immune-based interventions are promising strategies to achieve long-term cancer-free survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy while protecting normal cells, including hematopoietic stem and immune cells, from its toxic side effects. Here, we show that ... περισσότερα »
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Federico Pietrocola, Jonathan Pol, Erika Vacchelli, Shuan Rao, David P. Enot, Elisa E. Baracco, Sarah Levesque, Francesca Castoldi, Nicolas Jacquelot, Takahiro Yamazaki, Laura Senovilla, Guillermo Marino, Fernando Aranda, Sylvère Durand, Valentina Sica, Alexis Chery, Sylvie Lachkar, Verena Sigl, Norma Bloy, Aitziber Buque, Simonetta Falzoni, Bernhard Ryffel, Lionel Apetoh, Francesco Di Virgilio, Frank Madeo, Maria Chiara Maiuri, Laurence Zitvogel, Beth Levine, Josef M. Penninger, Guido Kroemer Calori... περισσότερα »
Metabolic Inflammation-Associated IL-17A Causes Non-alcoholic Steatohepatitis and Hepatocellular Carcinoma
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Ana L. Gomes, Ana Teijeiro, Stefan Burén, Krishna S. Tummala, Mahmut Yilmaz, Ari Waisman, Jean-Philippe Theurillat, Cristian Perna, Nabil Djouder Obesity increases hepatocellular carcinoma (HCC) risks via unknown mediators. We report that hepatic unconventional prefoldin RPB5 interactor (URI) couples nutrient surpluses to inflammation and non-alcoholic steatohepatitis (NASH), a common cause of HCC. URI-induced DNA damage in hepatocytes triggers inflammation via T helper 17 (Th17) lymphocytes and inte... περισσότερα »
Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Corentin Herbert, Ulrich Schieborr, Krishna Saxena, Jarek Juraszek, Frederik De Smet, Chantal Alcouffe, Marc Bianciotto, Giorgio Saladino, David Sibrac, Denis Kudlinzki, Sridhar Sreeramulu, Alan Brown, Patrice Rigon, Jean-Pascal Herault, Gilbert Lassalle, Tom L. Blundell, Frederic Rousseau, Ann Gils, Joost Schymkowitz, Peter Tompa, Jean-Marc Herbert, Peter Carmeliet, Francesco Luigi Gervasio, Harald Schwalbe, Françoise Bono from Cancer via ola Kala on Inoreader http://ift.tt/29J6Yq0 via IFTTT
CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Lu Wang, Zibo Zhao, Mark B. Meyer, Sandeep Saha, Menggang Yu, Ailan Guo, Kari B. Wisinski, Wei Huang, Weibo Cai, J. Wesley Pike, Ming Yuan, Paul Ahlquist, Wei Xu from Cancer via ola Kala on Inoreader http://ift.tt/29usyL5 via IFTTT
Design and development of a microarray processing station (MPS) for automated miniaturized immunoassays
Abstract Here we describe the design and evaluation of a fluidic device for the automatic processing of microarrays, called microarray processing station or MPS. The microarray processing station once installed on a commercial microarrayer allows automating the washing, and drying steps, which are often performed manually. The substrate where the assay occurs remains on place during the microarray printing, incubation and processing steps, therefore the addressing of nL volumes of the distinct immunoassay reagents such as capture and detection antibodies and samples can be performe... περισσότερα »
A simple microfluidic device to study cell-scale endothelial mechanotransduction
Abstract Atherosclerosis is triggered by chronic inflammation of arterial endothelial cells (ECs). Because atherosclerosis develops preferentially in regions where blood flow is disturbed and where ECs have a cuboidal morphology, the interplay between EC shape and mechanotransduction events is of primary interest. In this work we present a simple microfluidic device to study relationships between cell shape and EC response to fluid shear stress. Adhesive micropatterns are used to non-invasively control EC elongation and orientation at both the monolayer and single cell levels. The... περισσότερα »
Utilization and impact of adjuvant therapy in anaplastic oligodendroglioma: an analysis on 1692 patients
Abstract The aim of this study was to determine the utilization rates and impact of adjuvant therapy on overall survival (OS) for anaplastic oligodendroglioma (AO). Data were extracted from the National Cancer Data Base (NCDB). Chi square test, Kaplan–Meier method, and Cox regression models were employed in SPSS 22.0 (Armonk, NY: IBM Corp.) for data analyses. 1692 patients with AO who underwent surgery were identified. 945 (55.9 %) received adjuvant radiotherapy with concomitant chemotherapy (chemoRT), 102 (6.0 %) adjuvant radiotherapy (RT) sequentially followed by chemotherapy, 24... περισσότερα »
Anaplastic astrocytoma: prognostic factors and survival in 4807 patients with emphasis on receipt and impact of adjuvant therapy
Abstract To determine the receipt and impact of adjuvant therapy on overall survival (OS) for anaplastic astrocytoma (AA). Data were extracted from the National Cancer Data Base (NCDB). Chi square test, Kaplan–Meier method, and Cox regression models were employed in SPSS 22.0 (Armonk, NY: IBM Corp.) for data analyses. 4807 patients with AA diagnosed from 2004 to 2013 who underwent surgery were identified. 3243 (67.5 %) received adjuvant chemoRT, 525 (10.9 %) adjuvant radiotherapy (RT) alone, 176 (3.7 %) adjuvant chemotherapy alone and 863 (18.0 %) received no adjuvant therapy. Pati... περισσότερα »
Response to Fazekas and Overgaard: Degrees and Levels
[image: alertIcon.gif] Publication date: Available online 11 July 2016 *Source:*Trends in Cognitive Sciences Author(s): Tim Bayne, Jakob Hohwy, Adrian M. Owen from Neurology via xlomafota13 on Inoreader http://ift.tt/29zRJBE via IFTTT
Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort
Background Recent studies have demonstrated the superiority of endovascular therapy (EVT) for emergent large vessel occlusion. Objective To determine the effectiveness of EVT in nonagenarians, for whom data are limited. Methods We retrospectively reviewed clinical and imaging data of all patients who underwent EVT at two stroke centers between January 2012 and August 2014. The 90-day functional outcome (modified Rankin Scale (mRS) score) was compared between younger patients (age 18–89 years; n=175) and nonagenarians (n=18). The relationship between pre-stroke and 90-day post... περισσότερα »
Physiology 200 citation
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The prognostic significance of faecal calprotectin in patients with inactive inflammatory bowel disease
Summary Background Faecal calprotectin, an established biomarker used to assess mucosal inflammation, has been shown to correlate with endoscopic activity in inflammatory bowel disease (IBD). Longitudinal monitoring of faecal calprotectin, however, has rarely been employed beyond assessment of therapy response and *post hoc* analyses of clinical trials. Aim To study whether consecutive measurements of faecal calprotectin every third month are useful for monitoring patients with IBD in clinical remission. Methods Patients aged 18 years or older, with a known diagnosis of IBD in ... περισσότερα »
Deposition of radiocesium on the river flood plains around Fukushima
[image: S0265931X.gif] Publication date: November 2016 *Source:*Journal of Environmental Radioactivity, Volume 164 Author(s): Hiromitsu Saegusa, Takuya Ohyama, Kazuki Iijima, Hironori Onoe, Ryuji Takeuchi, Hiroki Hagiwara The environment in the area around Fukushima Daiichi Nuclear Power Plant has been contaminated by widely deposited significant amount of radioactive materials, which were released to the atmosphere caused by the Fukushima Daiichi Nuclear Power Plant accident due to the Great East Japan Earthquake, which occurred on March 11, 2011. The radiocesium released in the ac... περισσότερα »
Chemical Senses 20 citation
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds The emerging role of gasotransmitters in the pathogenesis of tuberculosis. Σάββατο, 9 Ιουλίου 2016, 1:54:15 μμ | Chinta KC, Saini V, Glasgow JN, Mazorodze JH, Rahman MA, Reddy D, Lancaster JR, Steyn AJ[image: Go to full article] *The emerging role of gasotransmitters in the pathogenesis of tuber... περισσότερα »
GROSS ANATOMICAL VARIATIONS IN THE THEBESIAN VALVE COVERING THE CORONARY SINUS OSTIUM: A CASE STUDY
2016-07-11T22-52-48Z *Source:* International Journal of Current Research and Review Anitha Thillai, Anjana TSR, Sivakami Thiagarajan. Objectives: The Coronary Sinus (CS) is a widely employed structure for cannulation during electrophysiologic procedures like catheter ablation of arrhythmias, implantation of resynchronization therapy devices and percutaneous mitral valve repair. The present study aims to evaluate the variations in the Thebesian valve covering the coronary sinus ostium. Materials and Methods: The present study was conducted in randomly selected 100 human cadaveric heart... περισσότερα »
Differences in knowledge related to dental implants between patients with and without a treatment history of dental implants
Abstract Objective This aim of this study was to investigate the differences between patients with and without a treatment history of dental implants by use of a questionnaire survey in order to determine the information that is required for patients undergoing dental implants. Materials and Methods The questionnaires were given to 4512 patients who visited the Tokyo Medical and Dental University Hospital for oral implants between January 2012 and December 2014, and 2972 (66%) valid questionnaires were collected. Results There were 857 patients with a treatment history of dental imp... περισσότερα »
Successful hematopoietic stem cell transplantation for myelofibrosis in an adult with Warts-Hypogammaglobulinemia-Immunodeficiency-Myelokathexis syndrome
Successful hematopoietic stem cell transplantation for myelofibrosis in an adult with Warts-Hypogammaglobulinemia-Immunodeficiency-Myelokathexis syndrome: Capsule Summary: Myelofibrosis can develop in patients with WHIM syndrome – hematopoietic stem cell transplantation is curative. Leen Moens, PhD Dep. of Microbiology and Immunology, Experimental Laboratory Immunology, Herestraat 49, 3000 Leuven Belgium Glynis Frans, MPharm Dep. of Microbiology and Immunology, Experimental Laboratory Immunology, Herestraat 49, 3000 Leuven, Belgium Barbara Bosch, MD Dep. of Pediatric Pulmonolog... περισσότερα »
Cause and occurrence timing of osteoradionecrosis of the jaw: a retrospective study focusing on prophylactic tooth extraction
AbstractPurpose This retrospective study aimed to analyze the relationship between tooth extraction and osteoradionecrosis (ORN) occurrence. The irradiation field, dose, and time interval between radiotherapy (RT) and ORN were reviewed. We also discuss appropriate guidelines for prophylactic tooth extraction. Methods A total of 33 patients treated for grade ≥2 (clinical) ORN in our department from 2002 to 2014 were enrolled. The following epidemiological data were retrospectively gathered: age, sex, histological diagnosis, primary tumor sites, radiation dose, chemotherapy, site of O... περισσότερα »
CHIP IMPLANTS & TEETH FILLINGS: Electronic Impulses Damaging to the Body, WDYCAS
The post CHIP IMPLANTS & TEETH FILLINGS: Electronic Impulses Damaging to the Body, WDYCAS appeared first on Family Dentistry and Cosmetic Surgery Clinic. http://ift.tt/29MjVOc
Role of fine-needle aspiration cytology in the diagnosis of major salivary gland tumors: A study with histological and clinical correlation
Role of fine-needle aspiration cytology in the diagnosis of major salivary gland tumors: A study with histological and clinical correlation: *Archana Shetty, V Geethamani* Journal of Oral and Maxillofacial Pathology 2016 20(2):224-229 Introduction: Neoplastic lesions of salivary glands present an interesting subject because of their histologic diversification. Complex features exhibited by them have aroused considerable speculations concerning their histogenesis and continues to hold the interest of clinicians and pathologists. Major salivary glands are superficial and have easy... περισσότερα »
Collagen synthesis starting from the nuclear transcription of the collagen genes, mRNA processing, ribosomal protein synthesis (translation) and posttranslational modifications, secretion and the final steps of fibril formation
*Schematic representation of collagen synthesis starting from the nuclear transcription of the collagen genes, mRNA processing, ribosomal protein synthesis (translation) and posttranslational modifications, secretion and the final steps of fibril formation. (SP: Signal peptidase; GT: Hydroxylysyl galactosyltransferase and galactosylhydroxylysyl glucosyltransferase; LH: Lysyl hydroxylase; PH: Prolylhydroxylase; OTC: Oligosaccharyl transferase complex; PDI: Protein disulphide isomerase; PPI: Peptidyl-prolyl cis-trans-isomerase; NP: Procollagen N-proteinase; CP: Procollagen C-protein... περισσότερα »
Types of collagen
[image: Table 1: Types of collagen] Enigmatic insight into collagen: *Shrutal Narendra Deshmukh, Alka M Dive, Rohit Moharil, Prashant Munde* Journal of Oral and Maxillofacial Pathology 2016 20(2):276-283 Collagen is a unique, triple helical molecule which forms the major part of extracellular matrix. It is the most abundant protein in the human body, representing 30% of its dry weight. It is the fibrous structural protein that makes up the white fibers (collagen fibers) of skin, tendons, bones, cartilage and all other connective tissues. Collagens are not only essentia... περισσότερα »
Special stains for collagen detection
[image: Table 2: Special stains for collagen detection] Enigmatic insight into collagen: *Shrutal Narendra Deshmukh, Alka M Dive, Rohit Moharil, Prashant Munde* Journal of Oral and Maxillofacial Pathology 2016 20(2):276-283 Collagen is a unique, triple helical molecule which forms the major part of extracellular matrix. It is the most abundant protein in the human body, representing 30% of its dry weight. It is the fibrous structural protein that makes up the white fibers (collagen fibers) of skin, tendons, bones, cartilage and all other connective tissues. Collagens are n... περισσότερα »
Categorization of collagen disorders
[image: Table 3: Categorization of collagen disorders] Enigmatic insight into collagen: *Shrutal Narendra Deshmukh, Alka M Dive, Rohit Moharil, Prashant Munde* Journal of Oral and Maxillofacial Pathology 2016 20(2):276-283 Collagen is a unique, triple helical molecule which forms the major part of extracellular matrix. It is the most abundant protein in the human body, representing 30% of its dry weight. It is the fibrous structural protein that makes up the white fibers (collagen fibers) of skin, tendons, bones, cartilage and all other connective tissues. Collagens are ... περισσότερα »
Collagen disorders and manifestations
* Collagen disorders and manifestations* [image: Table 4: Collagen disorders and manifestations] Enigmatic insight into collagen: *Shrutal Narendra Deshmukh, Alka M Dive, Rohit Moharil, Prashant Munde* Journal of Oral and Maxillofacial Pathology 2016 20(2):276-283 Collagen is a unique, triple helical molecule which forms the major part of extracellular matrix. It is the most abundant protein in the human body, representing 30% of its dry weight. It is the fibrous structural protein that makes up the white fibers (collagen fibers) of skin, tendons, bones, cartilage and a... περισσότερα »
Enigmatic insight into collagen
Enigmatic insight into collagen: *Shrutal Narendra Deshmukh, Alka M Dive, Rohit Moharil, Prashant Munde* Journal of Oral and Maxillofacial Pathology 2016 20(2):276-283 Collagen is a unique, triple helical molecule which forms the major part of extracellular matrix. It is the most abundant protein in the human body, representing 30% of its dry weight. It is the fibrous structural protein that makes up the white fibers (collagen fibers) of skin, tendons, bones, cartilage and all other connective tissues. Collagens are not only essential for the mechanical resistance and resilience... περισσότερα »
Estimation of major immunoglobulins in smokers and gutkha chewers
Estimation of major immunoglobulins in smokers and gutkha chewers: *Ketankumar Jayantilal Prajapati, Jyoti G Chawda* Journal of Oral and Maxillofacial Pathology 2016 20(2):219-223 Aim: To estimate the level of IgG and IgA major immunoglobulins in patients having the habit of smoking, gutkha chewing and in patients without any tobacco habit as control. Materials and Methods: Estimation of major immunoglobulins IgG and IgA was carried out by automated Nephelometry method in ten patients (control group), forty patients who had habit of smoking either bidi or cigarette and forty pa... περισσότερα »
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Burkitt's lymphoma: A case report and review
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Burkitt's lymphoma: A case report and review: *Tabita Joy Chettiankandy, Jagdish Vishnu Tupkari, Keshav Kumar, Manisha Sandeep Ahire* Journal of Oral and Maxillofacial Pathology 2016 20(2):333-333 B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and classical Burkitt's lymphoma (BL), is a diagnostic provisional category in the World Health Organization 2008 classification of lymphomas. This category was designed ... περισσότερα »
Expression of MUC1 mucin in potentially malignant disorders, oral squamous cell carcinoma and normal oral mucosa: An immunohistochemical study
Expression of MUC1 mucin in potentially malignant disorders, oral squamous cell carcinoma and normal oral mucosa: An immunohistochemical study: *M Harish Kumar, Karpagaselvi Sanjai, Jayalakshmi Kumarswamy, Roopavathi Keshavaiah, Lokesh Papaiah, S Divya* Journal of Oral and Maxillofacial Pathology 2016 20(2):214-218 Background: Mucins alteration in glycosylation is associated with the development and progression of malignant diseases. Therefore, mucins are used as valuable markers to distinguish normal and disease conditions. Many studies on MUC1 expression have been conducted on... περισσότερα »
Primary osteoclast-like giant cell tumor of parotid gland: A rare extraskeletal presentation with diagnostic challenges
Primary osteoclast-like giant cell tumor of parotid gland: A rare extraskeletal presentation with diagnostic challenges: *Ritika Singh, Sufian Zaheer, Ashish K Mandal* Journal of Oral and Maxillofacial Pathology 2016 20(2):331-331 Primary osteoclast-like giant cell tumor (OC-GCT) has been rarely described in extraskeletal sites. The diagnosis primarily hinges on the detection of giant cells. However, these giant cells are also seen in many giant cell lesions, thus creating diagnostic confusion and dilemma. Here, we describe a rare case of a 24-year-old male with primary extraske... περισσότερα »
Immunohistochemical evaluation of myofibroblasts in odontogenic cysts and tumors: A comparative study
Immunohistochemical evaluation of myofibroblasts in odontogenic cysts and tumors: A comparative study: *Deepa Syamala, Rakesh Suresh, Mahija Janardhanan, Vindhya Savithri, Prem P Anand, Amrutha Jose* Journal of Oral and Maxillofacial Pathology 2016 20(2):208-213 Context: Myofibroblasts are fibroblasts with smooth muscle-like features characterized by the presence of a contractile apparatus and found in the connective tissue stroma of normal tissues such as blood vessels and lymph nodes. They are now thought to play a role in the synthesis and reorganization of extracellular matr... περισσότερα »
Osteochondroma of maxillofacial region: Tumor arising from two different developmental bones
Osteochondroma of maxillofacial region: Tumor arising from two different developmental bones: *Sujata Mohanty, Himanshu Gupta, Jitender Dabas, Priyadarshan Kumar* Journal of Oral and Maxillofacial Pathology 2016 20(2):329-329 Osteochondromas are benign bony tumors which are commonly believed to originate by the proliferation of epiphyseal cartilage into the surrounding tissues. However, this hypothesis cannot explain the occurrence of this tumor in the intramembranous bones and soft tissue. Since most of the craniofacial bones have intramembranous origin, the occurrence of this ... περισσότερα »
Odontogenic tumors. Ameloblastoma was the most common odontogenic tumor comprising 50.2% of cases, followed by keratocystic odontogenic tumor (24.3%). These tumors showed a male predilection (1.19: 1). Odontogenic tumors occurred in a mean age of 33.7 ± 16.8 years. Mandible was the most common jaw affected (76.07%). Odontogenic cysts constituted 12.25% of all oral biopsies. Radicular cyst comprised 75.11% of odontogenic cysts followed by dentigerous cyst (17.2%).
A study of 1177 odontogenic lesions in a South Kerala population: *PV Deepthi, VT Beena, SK Padmakumar, R Rajeev, R Sivakumar* Journal of Oral and Maxillofacial Pathology 2016 20(2):202-207 Context: A study on odontogenic cysts and tumors. Aims: The aim of this study is to determine the frequency of odontogenic cysts and tumors and their distribution according to age, gender, site and histopathologic types of those reported over a period of 1998–2012 in a Tertiary Health Care Center at South Kerala. Settings and Design: The archives of Department of Oral Pathology and Microbio... περισσότερα »
Uncommon features in conventional oral squamous cell carcinoma
Uncommon features in conventional oral squamous cell carcinoma: *M Sudhakara, V Reshma, Nawal Khan, SR Amulya* Journal of Oral and Maxillofacial Pathology 2016 20(2):316-319 Introduction [image: Top] Oral cancer constitutes about 20 persons per 1 lakh population in India which accounts for about 30% of all types of cancers. Over five people die every hour every day due to oral cancer. International Agency for Research on Cancer has predicted that the Indian incidence of oral cancer will be 1.7 billion by 2035. Around 90-95% of oral cancers in India are squamous cell carcinoma... περισσότερα »
SOFPRO for the study of oral submucous fibrosis
Dental informatics tool “SOFPRO” for the study of oral submucous fibrosis: *Dinesh Masajirao Erlewad, Kalpana Anandrao Mundhe, Vinay K Hazarey* Journal of Oral and Maxillofacial Pathology 2016 20(2):194-201 Background: Dental informatics is an evolving branch widely used in dental education and practice. Numerous applications that support clinical care, education and research have been developed. However, very few such applications are developed and utilized in the epidemiological studies of oral submucous fibrosis (OSF) which is affecting a significant population of Asian count... περισσότερα »
White sponge nevus
White sponge nevus: Report of three cases in a single family: *Ngairangbam Sanjeeta, DB Nandini, Takhellambam Premlata, Sumita Banerjee* Journal of Oral and Maxillofacial Pathology 2016 20(2):300-303 White sponge nevus (WSN) is an interesting hereditary oral mucosal disorder that commonly manifests as bilaterally symmetrical, thickened white, corrugated or velvety, diffuse plaques that predominantly affects the buccal mucosa. The lesions may develop at birth or later in childhood or adolescence. Because it is asymptomatic and benign, WSN requires no treatment. Recognition of thi... περισσότερα »
Odontogenic tumors : Ameloblastoma (82.54%),adenomatoid odontogenic tumour (AOT) (6.35%) and odontogenic myxoma (4.76%).
Odontogenic tumors in Port Harcourt: South–South geopolitical zone of Nigeria: *CA Iyogun, OG Omitola, GE Ukegheson* Journal of Oral and Maxillofacial Pathology 2016 20(2):190-193 Aim: A retrospective study of odontogenic tumors (OTs) in Port Harcourt was undertaken to establish its prevalence and compare with known data in the literature from Nigeria and elsewhere. Materials and Methods: All pathologically diagnosed OTs between 2008 and 2013 at the archives of the Department of Oral Pathology and Oral Biology of the University of Port Harcourt/University of Port Harcourt Teachi... περισσότερα »
Prevalence and characterization of opportunistic candidal infections among patients with pulmonary tuberculosis
Prevalence and characterization of opportunistic candidal infections among patients with pulmonary tuberculosis: *Madhusudan Astekar, Priyanka Sharma Bhatiya, GV Sowmya* Journal of Oral and Maxillofacial Pathology 2016 20(2):183-189 Background: Although Candida albicans remains the most common cause of human candidiasis, the frequency of infection attributed to other members of the genus is also increasing. Hence, the present study was carried out to know the prevalence of opportunistic candidal infection in tuberculosis, and if positive, the species of Candida that is most comm... περισσότερα »
Juvenile nasopharyngeal angiofibroma
Juvenile nasopharyngeal angiofibroma: *Jashika Adil Shroff Makhasana, Meena A Kulkarni, Suhas Vaze, Adil Sarosh Shroff* Journal of Oral and Maxillofacial Pathology 2016 20(2):330-330 Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive neoplasm and shows a propensity for destructive local spread often extending to the base of the skull and into the cranium. Clinically, however, it is obscure with painless, progressive unilateral nasal obstruction being the common presenting symptom wit... περισσότερα »
Current status and future trends in telepathology and digital pathology
Current status and future trends in telepathology and digital pathology: *Trupti Dinesh Chordia, Ashok Vikey, Anuraag B Choudhary, Yashpal Samdariya, Dipti Samdariya Chordia* Journal of Oral and Maxillofacial Pathology 2016 20(2):178-182 Objective: The purpose of this study was to assess the current status and future trends in telepathology (TP) and digital pathology (DP) in central India. Materials and Methods: A self-constructed questionnaire including 12 questions was designed with five specialists, to improve the design ambiguity. The study was conducted through postal and ... περισσότερα »
Venolymphatic vascular malformation of the parotid gland extending into the parapharyngeal space: A rare presentation
Venolymphatic vascular malformation of the parotid gland extending into the parapharyngeal space: A rare presentation: *Yasmeen Khatib, Madhura Dande, Richa D Patel, Vinod Gite* Journal of Oral and Maxillofacial Pathology 2016 20(2):308-311 Vascular malformations (VMs) are structural malformations of vascular development causing soft tissue abnormality with functional and esthetic impairment. They are named by their predominant vessel type as arterial, venous, lymphatic or mixed types. VMs of the parotid gland are extremely rare and constitute a distinct entity of parotid pathol... περισσότερα »
Evaluation of natural killer cell (CD57) as a prognostic marker in oral squamous cell carcinoma: An immunohistochemistry study
Evaluation of natural killer cell (CD57) as a prognostic marker in oral squamous cell carcinoma: An immunohistochemistry study: *Rashmi Agarwal, Minal Chaudhary, Shruti Bohra, Shree Bajaj* Journal of Oral and Maxillofacial Pathology 2016 20(2):173-177 Objectives: Natural killer (NK) cells are important effector lymphocytes. NK cells are considered to represent innate immune system. NK cells target and kill aberrant cells such as virally infected and tumorigenic cells. The purpose of this study was to assess the expression of CD57 in oral squamous cell carcinoma (OSCC) and to cor... περισσότερα »
Epithelioid osteoblastoma of maxilla: A rare and aggressive variant of a benign neoplasm at an uncommon site
Epithelioid osteoblastoma of maxilla: A rare and aggressive variant of a benign neoplasm at an uncommon site: *Vandana Rana, Vivek Saxena, Kavita Sahai, Giriraj Singh* Journal of Oral and Maxillofacial Pathology 2016 20(2):332-332 Osteoblastoma (OB) is an uncommon benign bone-forming tumor accounting for & lt;1% of all bone neoplasms. Unlike conventional OB, its small subset variant “Epithelioid osteoblastoma (EO)” is characterized by its propensity for local invasion and recurrent behavior. This rare variant of an uncommon tumor when occurs in an atypical site can lead to diagnosti... περισσότερα »
Efferocytosis in oral squamous cell carcinoma
Efferocytosis in oral squamous cell carcinoma: *Gargi S Sarode* Journal of Oral and Maxillofacial Pathology 2016 20(2):170-172 Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of oral cavity, which is usually preceded by potentially malignant disorder. [1],[2] Unpredictable behavior such as tumor cell cannibalism,[3],[4],[5] microbial interactions with signaling pathways,[6]and psycho-cellular interactions [7] baffle us in understanding the tumor biology of OSCC. There are so many such unique aspects associated with OSCC that have a direct or indirect rel... περισσότερα »
Fatigue: a distressing symptom for patients with irritable bowel syndrome
Abstract Background Fatigue is a frequent symptom in patients with irritable bowel syndrome (IBS), and is associated with poor quality of life. However, few studies have evaluated its impact on daily life or the perceived distress it can cause. Using a multi-methods approach, this study describes the impact and manifestations of fatigue in patients with IBS and investigates the relationship between fatigue severity and illness-related and health-promoting factors. Methods A total of 160 patients with IBS completed self-reported questionnaires assessing fatigue, gastrointestinal ... περισσότερα »
Fatigue: a distressing symptom for patients with irritable bowel syndrome
Abstract Background Fatigue is a frequent symptom in patients with irritable bowel syndrome (IBS), and is associated with poor quality of life. However, few studies have evaluated its impact on daily life or the perceived distress it can cause. Using a multi-methods approach, this study describes the impact and manifestations of fatigue in patients with IBS and investigates the relationship between fatigue severity and illness-related and health-promoting factors. Methods A total of 160 patients with IBS completed self-reported questionnaires assessing fatigue, gastrointestinal sym... περισσότερα »
Combination of Ciclopirox Olamine and Sphingosine-1-phosphate as granulation enhancer in diabetic wounds
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
ABSTRACT Granulation tissue formation requires a robust angiogenic response. As granulation tissue develops, collagen fibers are deposited and compacted. Forces generated in the wake of this process drive wound contraction to reduce the wound area. In diabetics, both angiogenesis and wound contraction are diminished leading to impaired wound healing. To emulate this pathology and to […]
The Protective Value of Maternal Group B Streptococcus Antibodies: Quantitative and Functional Analysis of Naturally Acquired Responses to Capsular Polysaccharides and Pilus Proteins in European Maternal Sera
Naturally acquired antibody responses to Group B *Streptococcus* (GBS) capsular polysaccharides and pilus proteins were evaluated in a European population of pregnant women who delivered healthy or GBS-infected babies. The risk of neonatal infection decreases with the maternal anti-capsular polysaccharide immunoglobulin G level. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29KebYA via IFTTT
Switching Lopinavir/Ritonavir to Atazanavir/Ritonavir vs Adding Atorvastatin in HIV-Infected Patients Receiving Second-Line Antiretroviral Therapy With Hypercholesterolemia: A Randomized Controlled Trial
A randomized controlled trial was conducted among human immunodeficiency virus-infected patients receiving lopinavir/ritonavir-based regimens with hypercholesterolemia. Reduction of total cholesterol and low-density lipoprotein was significantly greater in patients who were randomized to the addition of atorvastatin compared with those who were switched from lopinavir/ritonavir to atazanavir/ritonavir. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29LD0k7 via IFTTT
Impact of Reported Beta-Lactam Allergy on Inpatient Outcomes: A Multicenter Prospective Cohort Study
Patients who did not receive preferred beta-lactam therapy due to reported beta-lactam allergy had an increased number of adverse events compared to patients without reported history of beta-lactam allergy. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29KeO4f via IFTTT
Early Response in Cellulitis: A Prospective Study of Dynamics and Predictors
In this prospective study of cellulitis, several non-pharmacological factors were associated with lack of early response. Such early non-response was rarely related to inappropriate therapy but strongly predictive of early treatment escalation, suggesting that broadening antibiotic treatment often may be premature. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29LDbMb via IFTTT
Fortune Favors the Bold: Give a Beta-Lactam!
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29KeClB via IFTTT
Reply to Chalmers, et al.
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29LCR0a via IFTTT
Adventures of a Female Medical Detective: In Pursuit of Smallpox and AIDS
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29KeDGb via IFTTT
Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29LD3fB via IFTTT
Empirical Coverage of MRSA in Community-Acquired Pneumonia: Those Who Do Not Remember the Past Are Doomed to Repeat it
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/29KdSgg via IFTTT
Population-level trends in the distribution of body mass index in England, 1992-2013
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background Changes over time of mean body weight or prevalence of overweight and obesity have been well documented. Less consideration has been given to describing the distribution to these changes particularly by socioeconomic status and sex. Methods We use data from the Health Survey for England for the years 1992–2013 to calculate the median, 5th […]
Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, and physical and biological agents that cause cancer in humans and has evaluated about 1000 agents since 1971. Monographs are written by ad hoc Working Groups (WGs) of international scientific experts over a period of […]
Challenges in reproducing results from publicly available data: an example of sexual orientation and cardiovascular disease risk
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background Replication is a vital part of the research process and has recently received considerable attention. Analyses using publicly available data should, if adequately described, be reproducible without assistance from the original investigators. Using data from the US National Health and Nutrition Examination Survey (NHANES), a recent study reported a statistically significant difference in cardiovascular […]
Visual impairment and the risk of mortality: addressing complex associations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
The worldwide rise in the ageing population has led to increasing levels of visual impairment.1 Visual impairment impacts on the individual with the potential to lead to loss of independence, falls, depression and reduced functional ability, and at a population level, there is an impact on the delivery of public health resources.1–3 Not only does […]
Are adolescent orphans more likely to be HIV-positive? A pooled data analyses across 19 countries in sub-Saharan Africa
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background Despite extensive resources and numerous programmes directed towards orphans in sub-Saharan Africa, evidence of their disadvantage is surprisingly limited. While initial research suggests that orphans are at greater risk of being HIV-positive, the evidence is limited in geographic scope. Methods To rigorously test disparities in HIV prevalence related to orphanhood and parental HIV status […]
School education, physical performance in late midlife and allostatic load: a retrospective cohort study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background The mechanisms underlying the social gradient in physical functioning are not fully understood. Cumulative physiological stress may be a pathway. The present study aimed to investigate the association between highest attained school education and physical performance in late midlife, and to determine to what extent cumulative physiological stress mediated these associations. Methods The study […]
The impact of SASA!, a community mobilisation intervention, on women’s experiences of intimate partner violence: secondary findings from a cluster randomised trial in Kampala, Uganda
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background Intimate partner violence (IPV) is a global public health and human rights concern, though there is limited evidence on how to prevent it. This secondary analysis of data from the SASA! Study assesses the potential of a community mobilisation IPV prevention intervention to reduce overall prevalence of IPV, new onset of abuse (primary prevention) […]
Marked socioeconomic inequalities in hip fracture incidence rates during the Bone and Joint Decade (2000-2010) in Portugal: age and sex temporal trends in a population based study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background Socioeconomic factors may influence changes in hip fracture (HF) incidence over time. We analysed HF temporal trends during the Bone and Joint Decade in Portugal (BJD-Portugal), 2000–2010, by regional socioeconomic status (SES), sex and age. Methods We selected registers of patients aged 50+ years with HF (International Classification of Diseases, V.9—Clinical Modification, ICD9-CM) caused […]
Are we selling our souls? Novel aspects of the presence in academic conferences of brands linked to ill health
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
There is evidence linking unhealthy food and drink consumption to ill health such as diabetes.1–3 Counterintuitively, research demonstrating these links has been presented at national and international health promotion conferences sponsored by companies that manufacture and sell unhealthy food and drink; primarily conferences related to public health, sport and exercise, nutrition and dietetics.45 For example, […]
Is regular drinking in later life an indicator of good health? Evidence from the English Longitudinal Study of Ageing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 25 δευτερόλεπτα
Background Older people who drink have been shown to have better health than those who do not. This might suggest that moderate drinking is beneficial for health, or, as considered here, that older people modify their drinking as their health deteriorates. The relationship between how often older adults drink and their health is considered for […]
In Vivo Neural Tissue Engineering: Cylindrical Biocompatible Hydrogels That Create New Neural Tracts in the Adult Mammalian Brain
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/29J4rvX via IFTTT
In Vivo Neural Tissue Engineering: Cylindrical Biocompatible Hydrogels That Create New Neural Tracts in the Adult Mammalian Brain
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 25 δευτερόλεπτα
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/29J4rvX via IFTTT
Hypothyroidism and Thyroid Autoimmunity as a Prognostic Biomarker of Better Response in Metastatic Cancer Long-Term Survivors Treated with Sunitinib
[image: access_no.gif] Thyroid , Vol. 0, No. 0. from thyroid via a.lsfakia on Inoreader http://ift.tt/29MaCho via IFTTT
MR neurography of a vagal neuropathy
A 46-year-old man with a history of recurrent facial nerve palsies, right trigeminal neuralgia, and Horner syndrome presented with subacute onset of right laryngeal hemiparesis. CSF analysis revealed normal cell count and elevated protein level with albumin-cytologic dissociation.1 Imaging workup ruled out compressive and infiltrative causes. Magnetic resonance neurography (figures 1A and 2, A–D) demonstrated uniform thickening, T2 signal hyperintensity, and contrast enhancement of the right vagal nerve, from skull base to the thyroid level. The right true vocal cord appeared addu... περισσότερα »
Preventing violence-related injuries in England and Wales: a panel study examining the impact of on-trade and off-trade alcohol prices
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 52 δευτερόλεπτα
Objective To examine the influence of real on-trade and off-trade alcohol prices and socioeconomic and environmental factors on rates of violence-related emergency department (ED) attendances in England and Wales over an 8-year period. Methods Anonymised injury data which included attendance date, age and gender of patients aged over 18 years who reported injury in violence […]
A potential relationship between skin hydration and stamp-type microneedle intradermal hyaluronic acid injection in middle-aged male face
Summary There is an increasing interest in skin rejuvenation using hyaluronic acid (HA) fillers beyond the improvement of deep wrinkles and volume deficiencies, which have been primary research foci in the past. We conducted a pilot study using a sample of six middle-aged male subjects. Using an automatic intradermal injector with 0.020 mL of material contained in each injection point with a total of 100 points, 2 mL of non-cross-HA filler was injected into the entire face at every treatment session. We administered injections of HA for a total of three sessions per subject at 2-w... περισσότερα »
Tele-aesthetics in South Asia
Summary Background Telemedicine is becoming increasingly popular. The best use for it is in the field of aesthetic dermatology – where conditions are not life-threatening, and treatments can be topical and very safe. Aims In this study, we demonstrate that a simple store-and-forward telemedicine system can be applied safely to the field of aesthetic dermatology. Methods and Materials This was a prospective study was carried out in Singapore. A total of 102 patients filled up a medical questionnaire and submitted photographs via our online system. Upon submission, there was an in... περισσότερα »
The Australasian Psoriasis Collaboration view on methotrexate for psoriasis in the Australasian setting
Abstract The Australasian Psoriasis Collaboration reviewed methotrexate (MTX) in the management of psoriasis in the Australian and New Zealand setting. The following comments are based on expert opinion and a literature review. Low-dose MTX (< 0.4 mg/kg per week) has a slow onset of action and has moderate to good efficacy, together with an acceptable safety profile. The mechanism of action is anti-inflammatory, rather than immunosuppressive. For pretreatment, consider testing full blood count (FBC), liver and renal function, non-fasting lipids, hepatitis serology, HbA1c and glucos... περισσότερα »
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Michaël Cerezo, Abdelali Lehraiki, Antoine Millet, Florian Rouaud, Magali Plaisant, Emilie Jaune, Thomas Botton, Cyril Ronco, Patricia Abbe, Hella Amdouni, Thierry Passeron, Veronique Hofman, Baharia Mograbi, Anne-Sophie Dabert-Gay, Delphine Debayle, Damien Alcor, Nabil Rabhi, Jean-Sébastien Annicotte, Laurent Héliot, Mariano Gonzalez-Pisfil, Caroline Robert, Solange Moréra, Armelle Vigouroux, Philippe Gual, Maruf M.U. Ali, Corine Bertolotto, Paul Hofman, Robert Ballotti, Rachid Benhida, Stéphane Roc... περισσότερα »
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Stefano Di Biase, Changhan Lee, Sebastian Brandhorst, Brianna Manes, Roberta Buono, Chia-Wei Cheng, Mafalda Cacciottolo, Alejandro Martin-Montalvo, Rafael de Cabo, Min Wei, Todd E. Morgan, Valter D. Longo Immune-based interventions are promising strategies to achieve long-term cancer-free survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy while protecting normal cells, including hematopoietic stem and immune cells, from its toxic side effects. Here, we show that ... περισσότερα »
NeuroSurgery
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* NeuroSurgery via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer a... περισσότερα »
Respiratory
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Unreliable Syndromes, Unreliable Studies Σάββατο, 9 Ιουλίου 2016, 7:06:14 μμ | Allan J. Walkey[image: Go to full article] [image: orcid.png] Annals of the American Thoracic Society, Volume 13, Issue 7, Page 1010-1011, July 2016. Classifying Chronic Lower Respiratory Disease Events in Epidemiolo... περισσότερα »
The New England Journal of Medicine
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds A Bruising Loss Πέμπτη, 7 Ιουλίου 2016, 3:25:50 μμ[image: Go to full article] Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular ... περισσότερα »
Toxicology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Toxicology via xlomafota13 on Inoreader Today, 12 Ιουλίου 2016, 8:12:02 πμ Neurotoxicity in Sri Lankan Russell’s Viper ( Daboia russelii ) Envenoming is Primarily due to U1-viperitoxin-Dr1a, a Pre-Synaptic Neurotoxin Today, 12 Ιουλίου 2016, 4 h... περισσότερα »
Therapeutics
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Systematic review with meta-analysis: ondansetron for vomiting in children with acute gastroenteritis Today, 12 Ιουλίου 2016, 48 minutes ago | E. Tomasik, E. Ziółkowska, M. Kołodziej, H. Szajewska[image: Go to full article] Summary Background Vomiting in children with acute gastroenteritis is a ... περισσότερα »
Swallowing and Swallowing Disorders (Dysphagia)
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Fatigue: a distressing symptom for patients with irritable bowel syndrome Today, 12 Ιουλίου 2016, 23 minutes ago | Å. Frändemark, E. Jakobsson Ung, H. Törnblom, M. Simrén, S. Jakobsson[image: Go to full article] Abstract Background Fatigue is a frequent symptom in patients with irritable bowel sy... περισσότερα »
Speech
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Speech via xlomafota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and ca... περισσότερα »
Sports Medicine
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Accelerometers for the Assessment of Concussion in Male Athletes: A Systematic Review and Meta-Analysis Today, 12 Ιουλίου 2016, 5 hours ago[image: Go to full article] AbstractBackgroundConcussion is common in the sporting arena and is often challenging to diagnose. The development of wearable he... περισσότερα »
Scope Medicine
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Correlation between serum uric acid, nitric oxide, ferrtin and HbA1c levels in type II diabetic patients Today, 12 Ιουλίου 2016, 5 hours ago[image: Go to full article] 2016-07-11T17-29-23Z *Source:* Journal of Investigational Biochemistry MAHALAXMI S PETIMANI, PRABHAKAR V ADAKE. Objectives: To e... περισσότερα »
Rheumatology
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds Pediatric musculoskeletal ultrasound: age- and sex-related normal B-mode findings of the knee Today, 12 Ιουλίου 2016, 4 hours ago[image: Go to full article] AbstractMusculoskeletal ultrasound (MSUS) is an important tool for evaluating disease activity, therapeutic progress, and remission status ... περισσότερα »
Surgery
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Surgery via xlomafota13 on Inoreader Today, 12 Ιουλίου 2016, 8:03:18 πμ Michel Gagner—Biography Today, 12 Ιουλίου 2016, 4 hours ago[image: Go to full article] Total minimally invasive esophagectomy for esophageal cancer: approaches and outcomes... περισσότερα »
Medicine 20 citation
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds It started with a kiss Today, 12 Ιουλίου 2016, 5 minutes ago | Kerruish, N., Anderson, L. C.[image: Go to full article] A medical student attempting to carry out a procedure such as inserting a cannula within a paediatric setting faces complex issues. First, because the student lacks experience... περισσότερα »
Medicine 80 citation
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* α via xloma.fota.13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can b... περισσότερα »
Vertigo
Alexandros G. SfakianakisστοOnline Medical Journals by Alexandros G.SfakianakisΠριν από 53 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* vertigo via xloma.fota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and ... περισσότερα »
Systematic review with meta-analysis: ondansetron for vomiting in children with acute gastroenteritis
Summary Background Vomiting in children with acute gastroenteritis is a common symptom, and it is considered to be the main cause of failure of oral rehydration therapy. Aim To systematically update evidence on the effects of ondansetron (5-HT3 serotonin antagonist) for vomiting in children with acute gastroenteritis. Methods The Cochrane Library, MEDLINE and EMBASE databases were searched up to April 2016, with no language restrictions, for randomised controlled trials (RCTs). Reference lists of reviews and included studies were examined. Results Ten RCTs involving 1215 partic... περισσότερα »
Cause and occurrence timing of osteoradionecrosis of the jaw: a retrospective study focusing on prophylactic tooth extraction
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 58 δευτερόλεπτα
Abstract Purpose This retrospective study aimed to analyze the relationship between tooth extraction and osteoradionecrosis (ORN) occurrence. The irradiation field, dose, and time interval between radiotherapy (RT) and ORN were reviewed. We also discuss appropriate guidelines for prophylactic tooth extraction. Methods A total of 33 patients treated for grade ≥2 (clinical) ORN in our department from 2002 to 2014 were enrolled. The following epidemiological data were retrospectively gathered: age, sex, histological diagnosis, primary tumor sites, radiation dose, chemotherapy, site o... περισσότερα »
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Michaël Cerezo, Abdelali Lehraiki, Antoine Millet, Florian Rouaud, Magali Plaisant, Emilie Jaune, Thomas Botton, Cyril Ronco, Patricia Abbe, Hella Amdouni, Thierry Passeron, Veronique Hofman, Baharia Mograbi, Anne-Sophie Dabert-Gay, Delphine Debayle, Damien Alcor, Nabil Rabhi, Jean-Sébastien Annicotte, Laurent Héliot, Mariano Gonzalez-Pisfil, Caroline Robert, Solange Moréra, Armelle Vigouroux, Philippe Gual, Maruf M.U. Ali, Corine Bertolotto, Paul Hofman, Robert Ballotti, Rachid Benhida, Stéphane Roc... περισσότερα »
Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Michaël Cerezo, Abdelali Lehraiki, Antoine Millet, Florian Rouaud, Magali Plaisant, Emilie Jaune, Thomas Botton, Cyril Ronco, Patricia Abbe, Hella Amdouni, Thierry Passeron, Veronique Hofman, Baharia Mograbi, Anne-Sophie Dabert-Gay, Delphine Debayle, Damien Alcor, Nabil Rabhi, Jean-Sébastien Annicotte, Laurent Héliot, Mariano Gonzalez-Pisfil, Caroline Robert, Solange Moréra, Armelle Vigouroux, Philippe Gual, Maruf M.U. Ali, Corine Bertolotto, Paul Hofman, Robert Ballotti, Rachid Benhida, Stéphane Rocch... περισσότερα »
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Stefano Di Biase, Changhan Lee, Sebastian Brandhorst, Brianna Manes, Roberta Buono, Chia-Wei Cheng, Mafalda Cacciottolo, Alejandro Martin-Montalvo, Rafael de Cabo, Min Wei, Todd E. Morgan, Valter D. Longo Immune-based interventions are promising strategies to achieve long-term cancer-free survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy while protecting normal cells, including hematopoietic stem and immune cells, from its toxic side effects. Here, we show that ... περισσότερα »
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
Publication date: 11 July 2016 *Source:*Cancer Cell, Volume 30, Issue 1 Author(s): Stefano Di Biase, Changhan Lee, Sebastian Brandhorst, Brianna Manes, Roberta Buono, Chia-Wei Cheng, Mafalda Cacciottolo, Alejandro Martin-Montalvo, Rafael de Cabo, Min Wei, Todd E. Morgan, Valter D. Longo Immune-based interventions are promising strategies to achieve long-term cancer-free survival. Fasting was previously shown to differentially sensitize tumors to chemotherapy while protecting normal cells, including hematopoietic stem and immune cells, from its toxic side effects. Here, we show that th... περισσότερα »
Cost-Effectiveness of a Model Infection Control Program for Preventing Multi-Drug-Resistant Organism Infections in Critically Ill Surgical Patients
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Surgical Infections , Vol. 0, No. 0. } http://ift.tt/29DDCtt
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