Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Δευτέρα 11 Ιουλίου 2016

OtoRhinoLaryngology & Medicine,New Articles,July 11th,2016,afternoon


New neurons reveal clues about an individual’s autism

The brains of some people with autism spectrum disorder grow faster than usual early on in life, often before diagnosis. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29HFnHm via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Deadly bug strikes in a day

A deadly bacteria that can be picked up by a simple sniff can travel to the brain and spinal cord in just 24 hours, a new Griffith University and Bond University study has found. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29J9jA4 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Waveform analysis for lumbar epidural needle placement in labour

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29sDtoK via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

A randomised placebo-controlled trial examining the effect on hand supination after the addition of a suprascapular nerve block to infraclavicular brachial plexus blockade

Summary Some surgeons believe that infraclavicular brachial plexus blocks tends to result in supination of the hand/forearm, which may make surgical access to the dorsum of the hand more difficult. We hypothesised that this supination may be reduced by the addition of a suprascapular nerve block. In a double-blind, randomised, placebo-controlled study, our primary outcome […]

AAGBI Safe vascular access guidelines I

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29GVALq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Issue Information – Editorial Board

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Plasma cholinesterase deficiency in Turkish patients

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29sDxVx via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Risk of bias and methodological appraisal practices in systematic reviews published in anaesthetic journals: a meta-epidemiological study

Summary The validity of primary study results included in systematic reviews plays an important role in drawing conclusions about intervention effectiveness and carries implications for clinical decision-making. We evaluated the prevalence of methodological quality and risk of bias assessments in systematic reviews published in the five highest-ranked anaesthesia journals since 2007. The initial PubMed search […]

The ‘Bath Boarding Card’: a novel tool for improving pre-operative care for emergency laparotomy patien ts

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29GVTpD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Plasma cholinesterase deficiency in Turkish patients – a reply

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29sDLvO via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Abandoning use of 1st generation SAD – a reply

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Eosinophilic Disorders

On this page Basics Summary Start Here Diagnosis and Tests Learn More Living With Specifics Genetics See, Play and Learn No links available Research Clinical Trials Journal Articles Resources Reference Desk Find an Expert For You Children Patient Handouts Summary Eosinophils are a type of white blood cell. They help fight off infections and play […]

Psychosocial distress and its effects on the health-related quality of life of primary brain tumor patients

Psychosocial distress and its effects on the health-related quality of life of primary brain tumor patients: CNS Oncology Ahead of Print. from Cancer via ola Kala on Inoreader via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29xJRLZ via IFTTT

Do I need ethics for this?

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Primary Cell Culture Systems for Human Thyroid Studies

To cite this article: Wang Yanqiang, Li Wei, Phay John E., Shen Rulong, Pellegata Natalia S., Saji Motoyasu, Ringel Matthew D., Chapelle Albert de la, and He Huiling. Thyroid. July 2016, ahead of print. doi:10.1089/thy.2015.0518. Full Text HTML Full Text PDF (598.5 KB) Full Text PDF with Links (500.7 KB) Author information Yanqiang Wang,1 Wei […]

Propofol infusion in children

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Abandoning first generation supraglottic airway devices

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Perinatal Iron Deficiency-Induced Hypothyroxinemia Impairs Early Brain Development Regardless of Normal Iron Levels in the Neonatal Brain

Perinatal Iron Deficiency-Induced Hypothyroxinemia Impairs Early Brain Development Regardless of Normal Iron Levels in the Neonatal Brain: Thyroid Jul 2016, Vol. 26, No. 7: 891-900. Author information Xiaona Hu,1,2* Ranran Wang,1* Zhongyan Shan,1 Yujie Dong,3 Hongzhi Zheng,1 Forrest Fabian Jesse,3Elizabeth Rao,3 Eiki Takahashi,4 Weidong Li,3 Weiping Teng,1 and Xiaochun Teng1 1Department of Endocrinology and Metabolism, […]

Study of efficacy of oral ivermectin in comparison to commonly used topical antiscabetic drugs gamma benzene hexachloride and permethrin

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 3 δευτερόλεπτα
2016-07-11T04-36-21Z *Source:* International Journal of Basic & Clinical Pharmacology Suman Kanwar, Sunil K. Mathur, Sanjay Sankhla. Background: Scabies is an infectious disease, contagious in nature and caused by Sarcoptes Scabiei, is transmitted readily, often throughout an entire household, by prolonged skin-to-skin contact with an infected person. The objective was to know the efficacy of oral ivermectin in the treatment of scabies infection in comparison to commonly used topical antiscabetic drugs gamma benzene hexachloride and permethrin. Methods: Using prospective, longitudin... περισσότερα »

Modification of a Minimally Invasive Conjunctivodacryocystorhinostomy With Jones Tube Placement

Modification of a Minimally Invasive Conjunctivodacryocystorhinostomy With Jones Tube Placement: http://ift.tt/29BqbdR

Revisiting the Role of the Myofibroblast in Socket Surgery: An Immunohistochemical Study

Revisiting the Role of the Myofibroblast in Socket Surgery: An Immunohistochemical Study: Purpose: To determine the impact of a single injection of various anti-inflammatory, antimitotic, and antiangiogenic agents on the cell count of myofibroblasts in an eviscerated socket. Methods: One eye from 15 skeletally mature New Zealand white rabbits was eviscerated, and the rabbits were […]

Esophageal remnant cancer 35 years after acidic caustic injury: A case report.

Esophageal remnant cancer 35 years after acidic caustic injury: A case report. Int J Surg Case Rep. 2016 Jul 1;25:215-217 Authors: Ntanasis-Stathopoulos I, Triantafyllou S, Xiromeritou V, Bliouras N, Loizou C, Theodorou D Abstract INTRODUCTION: Esophageal squamous cell carcinoma has been described as a long-term consequence following ingestion of corrosive substances. PRESENTATION OF CASE: We […]

Predicting the Surgical Margin of Resection in Periocular Cutaneous Neoplasms and the Significance of Reconstruction Following Mohs Micrographic Surgery

Predicting the Surgical Margin of Resection in Periocular Cutaneous Neoplasms and the Significance of Reconstruction Following Mohs Micrographic Surgery: Abstract Purpose: To evaluate the features of periocular cutaneous malignancies that may contribute to larger surgical defects or require more complex reconstructive procedures. Methods: A retrospective review of 181 patients with biopsy proven periocular cutaneous malignancies […]

Nasolacrimal duct obstruction following radioiodine treatment

Iodine-131 Therapy and Nasolacrimal Duct Obstructions: What We Know and What We Need to Know: Purpose: The aims of the current review are to summarize the etiopathogenesis, symptomatology, management, complications, and outcomes of iodine-131-induced nasolacrimal duct obstructions, to propose a screening protocol and elucidate the potential avenues of future research. Methods: The authors performed an […]

Canine bites

Ocular Trauma From Dog Bites: Characterization, Associations, and Treatment Patterns at a Regional Level I Trauma Center Over 11 Years: Abstract Purpose: Canine bites frequently result in periocular injury. The authors aimed to further characterize the dog breeds, types of injuries inflicted, and treatment outcomes. Methods: A retrospective chart review was performed on all dog […]

Acantholytic Acanthoma of the Eyelid: Unusual Presentation

Acantholytic Acanthoma of the Eyelid: Unusual Presentation: Acantholytic acanthoma is a benign epidermal tumor with a truncal predisposition and is not previously reported as an eyelid mass. A 63-year-old man, presented with a history of nodular masses of both his eyelid margin and eyelid surface of 3 years duration. Excision biopsy of lesion of eyelid […]

Etiology and Management of Allergic Eyelid Dermatitis.

Etiology and Management of Allergic Eyelid Dermatitis.: Purpose: Allergic dermatitis is a common but often misdiagnosed condition that can present with a variety of findings including inflammation, eyelid malposition, and tearing. This study was performed to identify likely etiologies, along with presenting findings and treatment strategies for allergic dermatitis. Methods: A retrospective review of clinical […]

Eosinophilic Disorders

On this page Basics Summary Start Here Diagnosis and Tests Learn More Living With Specifics Genetics See, Play and Learn No links available Research Clinical Trials Journal Articles Resources Reference Desk Find an Expert For You Children Patient Handouts Summary Eosinophils are a type of white blood cell. They help fight off infections and play […]

Esophageal remnant cancer 35 years after acidic caustic injury: A case report.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Esophageal remnant cancer 35 years after acidic caustic injury: A case report.* Int J Surg Case Rep. 2016 Jul 1;25:215-217 Authors: Ntanasis-Stathopoulos I, Triantafyllou S, Xiromeritou V, Bliouras N, Loizou C, Theodorou D Abstract INTRODUCTION: Esophageal squamous cell carcinoma has been described as a long-term consequence following ingestion of corrosive substances. PRESENTATION OF CASE: We report a rare case of a 62-year-old female patient with a history of acidic caustic injury 35 years ago, for which she had undergone near total esophagogastrectomy with right colon interpos... περισσότερα »

Esophageal remnant cancer 35 years after acidic caustic injury: A case report.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
*Esophageal remnant cancer 35 years after acidic caustic injury: A case report.* Int J Surg Case Rep. 2016 Jul 1;25:215-217 Authors: Ntanasis-Stathopoulos I, Triantafyllou S, Xiromeritou V, Bliouras N, Loizou C, Theodorou D Abstract INTRODUCTION: Esophageal squamous cell carcinoma has been described as a long-term consequence following ingestion of corrosive substances. PRESENTATION OF CASE: We report a rare case of a 62-year-old female patient with a history of acidic caustic injury 35 years ago, for which she had undergone near total esophagogastrectomy with right colon interpos... περισσότερα »

Experimental study on penetration of dental implants into the maxillary sinus at different depths.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 10 δευτερόλεπτα
*Experimental study on penetration of dental implants into the maxillary sinus at different depths.* Oral Maxillofac Surg. 2016 Jul 9; Authors: Elhamruni LM, Marzook HA, Ahmed WM, Abdul-Rahman M Abstract OBJECTIVE: The purpose of this study was to investigate the effect of the dental implant penetration into the maxillary sinus cavity in different depths on implant and sinus health in a dog model. MATERIALS AND METHODS: The study sample included eight titanium dental implant placed in four female dogs immediately after extraction of the first maxillary molar in the palatal socket ... περισσότερα »

Shared Decision Making in the Emergency Department: Development of a Policy-Relevant Patient-Centered Research Agenda

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Abstract A 6-year-old otherwise healthy girl is brought to the emergency department (ED) by her parents after waking up at 3 a.m. saying that her tummy hurts. She had not eaten dinner the evening before because of stomach pain, but seemed better after being given acetaminophen and falling asleep in her bed. She has not vomited and has had no diarrhea, though when asked where she hurts she points to her periumbilical region. On examination, she is interactive and appears well, has normal vital signs, and is afebrile. She is mildly tender in the periumbilical region and right lower qu... περισσότερα »

‘From Tears to Transparency: A conversation can change an outcome. A conversation can change a life (™)’: Reflections from Patient Advocates

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 12 δευτερόλεπτα
Abstract The Society for Academic Emergency Medicine (SAEM) consensus conference provided many platforms for patient advocates to share their experiences and demonstrate the powerful contribution they have to offer to the decision-making process. One such platform was the presentation of a film ‘The Faces of Medical Error: From Tears to Transparency’ shared by Patty and David Skolnik. In this article the Skolniks build on their story shared at the SAEM consensus conference and the panel discussion. They provide further insight drawn from nine years of experiences as advocates for p... περισσότερα »

Abandoning use of 1st generation SAD – a reply

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
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Cadaveric training – the solution for ultrasound-guided regional anaesthesia?

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
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Perineural or intravenous dexamethasone: do we still need catheters?

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
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IJMS, Vol. 17, Pages 1108: MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
IJMS, Vol. 17, Pages 1108: MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera: Non-melanoma skin cancer is the most common skin cancer with an incidence that varies widely worldwide. Among them, actinic keratosis (AK), considered by some authors as in situ squamous cell carcinoma (SCC), are the most common… Continue reading IJMS, Vol. 17, Pages 1108: MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera

IJMS, Vol. 17, Pages 1108: MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
IJMS, Vol. 17, Pages 1108: MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera: Non-melanoma skin cancer is the most common skin cancer with an incidence that varies widely worldwide. Among them, actinic keratosis (AK), considered by some authors as in situ squamous cell carcinoma (SCC), are the most common… Continue reading IJMS, Vol. 17, Pages 1108: MAL Daylight Photodynamic Therapy for Actinic Keratosis: Clinical and Imaging Evaluation by 3D Camera

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity. Ophthalmology. 2016 Jul 7; Authors: Grenier J, Meunier I, Daien V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP Abstract PURPOSE: To search for WFS1 mutations in patients with optic… Continue reading WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity. Ophthalmology. 2016 Jul 7; Authors: Grenier J, Meunier I, Daien V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP Abstract PURPOSE: To search for WFS1 mutations in patients with optic… Continue reading WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
Publication date: Available online 29 June 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Daniela Cerny, Duyen Huynh Thi Le, Trung Dinh The, Roland Zuest, K.G. Srinivasan, Sumathy Velumani, Chiea Chuen Khor, Lucia Mori, Cameron P. Simmons, Michael Poidinger, Francesca Zolezzi, Florent Ginhoux, Muzlifah Haniffa, Bridget Wills, Katja Fink from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader… Continue reading Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence

Assessing the Impact of Engineered Nanomaterials on the Environment and Human Health

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
Publication date: Available online 27 June 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Sean M. Geary, Angie S. Morris, Aliasger K. Salem from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29IEmvG via IFTTT

Asthma and the Olympics

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 19 δευτερόλεπτα
Publication date: Available online 23 June 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Kai-Håkon Carlsen, Karin C. Lødrup Carlsen from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29OVRx1 via IFTTT

Issue Information – Editorial Board

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Risk of bias and methodological appraisal practices in systematic reviews published in anaesthetic journals: a meta-epidemiological study

Summary The validity of primary study results included in systematic reviews plays an important role in drawing conclusions about intervention effectiveness and carries implications for clinical decision-making. We evaluated the prevalence of methodological quality and risk of bias assessments in systematic reviews published in the five highest-ranked anaesthesia journals since 2007. The initial PubMed search […]

Overexpression of Dishevelled-2 contributes to proliferation and migration of human esophageal squamous cell carcinoma

Overexpression of Dishevelled-2 contributes to proliferation and migration of human esophageal squamous cell carcinoma: Abstract Dishevelled-2 (Dvl2) was associated with tumor cell proliferation and migration. We aimed to examine the mechanism of Dvl2 in esophageal squamous cell carcinoma (ESCC). Dvl2 was overexpressed in human ESCC tissues and cell lines ECA109 and TE1 cells. CCK-8 and […]

Chondrogenic cells respond to partial-thickness defects of articular cartilage

in adult rats: an in vivo study: Abstract The purpose of this study was to establish a partial-thickness articular cartilage defects model in adult rats and explore the respond of chondrogenic cells to the cartilage injury. Forty-five adult Sprague–Dawley rats were divided into operated group, sham-operated group and control group. Partial-thickness cartilage defects were created […]

Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury

Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury: Abstract Adenosine kinase (ADK) plays a pivotal role in regulating brain function by regulating adenosine level, and ADK inhibition protects against neuronal damage in cerebral ischemia and epilepsy; however, the effects of ADK in traumatic brain injury (TBI) have not been investigated. For exploring […]

CBX7 deficiency plays a positive role in dentin and alveolar bone development

CBX7 deficiency plays a positive role in dentin and alveolar bone development: Abstract To clarify the role of CBX7 deficiency in dentin and alveolar bone development, the dental and mandibular phenotypes of homozygous CBX7-knockout (CBX7−/−) mice were compared with their wild-type (WT) counterparts at 3 weeks age. In contrast to WT littermates, dental volume and dentin […]

Neuroprotective potential of Linezolid

a quantitative and distribution study via mass spectrometry: Abstract A study was undertaken to determine the neuroprotective potential of Linezolid (LIN) in an animal model. Female Sprague–Dawley rats were either given a single (100 mg/kg) dose or treated daily for 4 weeks. A validated LC–MS/MS method was used to measure LIN levels in plasma and brain, this […]

Experimental study on penetration of dental implants into the maxillary sinus at different depths.

Experimental study on penetration of dental implants into the maxillary sinus at different depths. Oral Maxillofac Surg. 2016 Jul 9; Authors: Elhamruni LM, Marzook HA, Ahmed WM, Abdul-Rahman M Abstract OBJECTIVE: The purpose of this study was to investigate the effect of the dental implant penetration into the maxillary sinus cavity in different depths on […]

Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls.

Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls. Environ Int. 2016 Jul 6; Authors: Shah-Kulkarni S, Kim BM, Hong YC, Kim HS, Kwon EJ, Park H, Kim YJ, Ha EH Abstract Perfluorinated compounds (PFCs) are ubiquitous in the environment and have been detected in humans and wildlife. Exposure to PFCs has […]

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity. Ophthalmology. 2016 Jul 7; Authors: Grenier J, Meunier I, Daien V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP Abstract PURPOSE: To search for WFS1 mutations in patients with optic […]

Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study.

Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study. Eur Arch Otorhinolaryngol. 2016 Jul 9; Authors: Branco C, Monteiro D, Paço J Abstract Myringotomy with the insertion of ventilation tubes is the most frequent surgical procedure performed in children, and the appearance of myringosclerosis is one of its most […]

DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes

Publication date: Available online 7 July 2016Source:Journal of Allergy and Clinical Immunology Author(s): Roser Vento-Tormo, Damiana Álvarez-Errico, Antonio Garcia-Gomez, José Hernández-Rodríguez, Segundo Buján, Maria Basagaña, Maria Méndez, Jordi Yagüe, Manel Juan, Juan I. Aróstegui, Esteban BallestarBackgroundInflammasomes are cytosolic multiprotein complexes in macrophages. They assemble after infection- or stress-associated stimuli, activating both caspase-1–mediated inflammatory cytokine secretion […]

Psychosocial distress and its effects on the health-related quality of life of primary brain tumor patients

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 24 δευτερόλεπτα
CNS Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/29sBoJm via IFTTT

Commonly Employed African Neonatal Skin Care Products Compromise Epidermal Function in Mice

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 25 δευτερόλεπτα
Abstract Background Neonatal mortality is much higher in the developing world than in developed countries. Infections are a major cause of neonatal death, particularly in preterm infants, in whom defective epidermal permeability barrier function facilitates transcutaneous pathogen invasion. The objective was to determine whether neonatal skin care products commonly used in Africa benefit or compromise epidermal functions in murine skin. Methods After twice-daily treatment of 6- to 8-week-old hairless mice with each skin care product for 3 days, epidermal permeability barrier func... περισσότερα »

Infantile Hemangiomas of the Lip: Patterns, Outcomes, and Implications

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 25 δευτερόλεπτα
Abstract Background Infantile hemangiomas of the lip are potentially problematic because of high visibility and risk of disfigurement and ulceration. This study examined sizes, patterns, and locations of lip hemangiomas, their prognostic value, and their implications in hemangioma pathogenesis. Methods Records of 106 patients seen for lip hemangiomas from 2006 to 2013 at Nationwide Children's Hospital were reviewed. Localized hemangiomas were mapped to a location on the lip based on their focus. Size, location, and morphology were assessed with regard to outcome. Poor outcomes we... περισσότερα »

Probable Griseofulvin-Induced Drug Reaction with Eosinophilia and Systemic Symptoms in a Child

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 25 δευτερόλεπτα
Abstract A 9-year-old boy presented with fever, rash, anterior cervical lymphadenopathy, high liver enzymes, atypical lymphocytosis, and eosinophilia (drug reaction with eosinophilia and systemic symptoms [DRESS]). His history was notable for having taken griseofulvin for 3 weeks prior to onset of these findings. He improved after treatment with oral prednisone. We present a rare case of probable DRESS secondary to griseofulvin. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/29ILubj via IFTTT

Epigenetic silencing of TIMP4 in heart failure

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Abstract Tissue inhibitor of matrix metalloprotease 4 (TIMP4) is endogenously one of the key modulators of matrix metalloprotease 9 (MMP9) and we have reported earlier that cardiac specific TIMP4 instigates contractility and helps in differentiation of cardiac progenitor cells. Although studies show that the expression of TIMP4 goes down in heart failure but the mechanism is unknown. This study aims to determine the mechanism of silencing of TIMP4 in heart failure progression created by aorta-vena cava (AV) fistula. We hypothesize that there is epigenetic silencing of TIMP4 in hear... περισσότερα »

Store-operated calcium entry is required for sustained contraction and Ca2+ oscillations of airway smooth muscle

Abstract Asthma is characterized by airway hyper-responsiveness – the excessive contraction of airway smooth muscle. The extent of this airway contraction is proportional to the frequency of Ca2+ oscillations within airway smooth muscle cells (ASMCs). Sustained Ca2+ oscillations require a Ca2+ influx to replenish Ca2+ losses across the plasma membrane. Our previous studies implied store-operated […]

Superior mitochondrial adaptations in human skeletal muscle after interval compared to continuous single-leg cycling matched for total work

Abstract We employed counterweighted single-leg cycling as a unique model to investigate the role of exercise intensity in human skeletal muscle remodelling. Ten young active men performed unilateral graded-exercise tests to measure single-leg VO2peak and peak power (Wpeak). Each leg was randomly assigned to complete six sessions of high-intensity interval training (HIIT; 4 x [5 min […]

Journal of Plastic, Reconstructive & Aesthetic Surgery

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OtoRhinoLaryngology & Medicine

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Lasers in Surgery and Medicine

Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed! Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! Latest Results You are […]

Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival.

Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival. Eur J Intern Med. 2016 Jul 7; Authors: Kanbay M, Afsar B, Siriopol D, Unal HU, Karaman M, Saglam M, Gezer M, Taş A, Eyileten T, Guler AK, Aydin İ, Oguz Y, Tarim K, Covic A, Yilmaz MI Abstract BACKGROUND AND […]

Ratio of intra-operative fluid to anesthesia time and its impact on short term perioperative outcomes following gastrectomy for cancer: a retrospective cohort study.

Ratio of intra-operative fluid to anesthesia time and its impact on short term perioperative outcomes following gastrectomy for cancer: a retrospective cohort study. Int J Surg. 2016 Jul 6; Authors: Enomoto LM, Blackham A, Woo Y, Yamamoto M, Pimiento J, Gusani NJ, Wong J Abstract BACKGROUND: This study evaluates the short-term impact of fluid administration […]

Multimodal Analgesia: A systematic review of local NSAIDs for non-ophthalmologic postoperative pain management.

Multimodal Analgesia: A systematic review of local NSAIDs for non-ophthalmologic postoperative pain management. Int J Surg. 2016 Jul 6; Authors: Brubaker L, Kendall L, Reina E Abstract INTRODUCTION: While the analgesic benefits of systemically administered non-steroidal anti-inflammatory drugs (NSAIDs) for postoperative pain are well established, benefits of locally administered NSAIDs remain unclear outside the field […]

Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure – the EGEA study

Publication date: Available online 22 June 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Valérie Siroux, Christian Lupinek, Yvonne Resch, Mirela Curin, Jocelyne Just, Thomas Keil, Renata Kiss, Karin Lodrup Carlsen, Erik Melén, Rachel Nadif, Isabelle Pin, Ingebjørg Skrindo, Susanne Vrtala, Magnus Wickman, Josep Maria Anto, Rudolf Valenta, Jean Bousquet BackgroundThe nature of allergens, route […]

Assessing the Impact of Engineered Nanomaterials on the Environment and Human Health

Publication date: Available online 27 June 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Sean M. Geary, Angie S. Morris, Aliasger K. Salem http://ift.tt/29IEmvG from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29P0nvl via IFTTT

Viruses, Vol. 8, Pages 191: Heat Shock Enhances the Expression of the Human T Cell Leukemia Virus Type-I (HTLV-I) Trans-Activator (Tax) Antigen in Human HTLV-I Infected Primary and Cultured T Cells

The environmental factors that lead to the reactivation of human T cell leukemia virus type-1 (HTLV-I) in latently infected T cells in vivo remain unknown. It has been previously shown that heat shock (HS) is a potent inducer of HTLV-I viral protein expression in long-term cultured cell lines. However, the precise HTLV-I protein(s) and mechanisms […]

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 32 δευτερόλεπτα
*WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.* Ophthalmology. 2016 Jul 7; Authors: Grenier J, Meunier I, Daien V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP Abstract PURPOSE: To search for WFS1 mutations in patients with optic atrophy (OA) and assess visual impairment. DESIGN: Retrospective molecular genetic and clinical study. PARTICIPANTS: Patients with OA followed at a national referral center specialized in genetic sensory diseases. METHODS: Mutation sc... περισσότερα »

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 32 δευτερόλεπτα
*WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.* Ophthalmology. 2016 Jul 7; Authors: Grenier J, Meunier I, Daien V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP Abstract PURPOSE: To search for WFS1 mutations in patients with optic atrophy (OA) and assess visual impairment. DESIGN: Retrospective molecular genetic and clinical study. PARTICIPANTS: Patients with OA followed at a national referral center specialized in genetic sensory diseases. METHODS: Mutation sc... περισσότερα »

Interactive Voice Response-An Innovative Approach to Post-Stroke Depression Self-Management Support.

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 32 δευτερόλεπτα
*Interactive Voice Response-An Innovative Approach to Post-Stroke Depression Self-Management Support.* Transl Stroke Res. 2016 Jul 9; Authors: Skolarus LE, Piette JD, Pfeiffer PN, Williams LS, Mackey J, Hughes R, Morgenstern LB Abstract Automated interactive voice response (IVR) call systems can provide systematic monitoring and self-management support to depressed patients, but it is unknown if stroke patients are able and willing to engage in IVR interactions. We sought to assess the feasibility and acceptability of IVR as an adjunct to post-stroke depression follow-up care. Th... περισσότερα »

Development of supramolecular ensemble of AIEE active hexaphenylbenzene derivative and Ag@Cu2O core-shell NPs: An efficient photocatalytic system for C-H activation

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 33 δευτερόλεπτα
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC03956A, Communication Radhika Chopra, Manoj Kumar, Vandana Bhalla Supramolecular ensemble having Ag@Cu2O core-shell nanoparticles stabilized by aggregates of hexaphenylbenzene derivative has been developed which exhibits excellent photocatalytic efficiency in reactions involving preparation of imidazole and benzimidazole derivatives via... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/29yTHOJ via IFTTT

Journal of Plastic, Reconstructive & Aesthetic Surgery

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 35 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Journal of Plastic, Reconstructive & Aesthetic Surgery *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to yo... περισσότερα »

Lasers in Surgery and Medicine

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 35 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* Latest Results *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Intern... περισσότερα »

Shared Decision Making in the Emergency Department: Development of a Policy-Relevant Patient-Centered Research Agenda

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Abstract A 6-year-old otherwise healthy girl is brought to the emergency department (ED) by her parents after waking up at 3 a.m. saying that her tummy hurts. She had not eaten dinner the evening before because of stomach pain, but seemed better after being given acetaminophen and falling asleep in her bed. She has not vomited and has had no diarrhea, though when asked where she hurts she points to her periumbilical region. On examination, she is interactive and appears well, has normal vital signs, and is afebrile. She is mildly tender in the periumbilical region and right lower qu... περισσότερα »

‘From Tears to Transparency: A conversation can change an outcome. A conversation can change a life (™)’: Reflections from Patient Advocates

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Abstract The Society for Academic Emergency Medicine (SAEM) consensus conference provided many platforms for patient advocates to share their experiences and demonstrate the powerful contribution they have to offer to the decision-making process. One such platform was the presentation of a film ‘The Faces of Medical Error: From Tears to Transparency’ shared by Patty and David Skolnik. In this article the Skolniks build on their story shared at the SAEM consensus conference and the panel discussion. They provide further insight drawn from nine years of experiences as advocates for p... περισσότερα »

Ratio of intra-operative fluid to anesthesia time and its impact on short term perioperative outcomes following gastrectomy for cancer: a retrospective cohort study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Ratio of intra-operative fluid to anesthesia time and its impact on short term perioperative outcomes following gastrectomy for cancer: a retrospective cohort study.* Int J Surg. 2016 Jul 6; Authors: Enomoto LM, Blackham A, Woo Y, Yamamoto M, Pimiento J, Gusani NJ, Wong J Abstract BACKGROUND: This study evaluates the short-term impact of fluid administration during gastrectomy for cancer. METHODS: A multi-institutional database of patients undergoing gastrectomy for cancer from three tertiary centers was reviewed. Logistic and linear regression analyses were performed. RESULTS: ... περισσότερα »

Multimodal Analgesia: A systematic review of local NSAIDs for non-ophthalmologic postoperative pain management.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Multimodal Analgesia: A systematic review of local NSAIDs for non-ophthalmologic postoperative pain management.* Int J Surg. 2016 Jul 6; Authors: Brubaker L, Kendall L, Reina E Abstract INTRODUCTION: While the analgesic benefits of systemically administered non-steroidal anti-inflammatory drugs (NSAIDs) for postoperative pain are well established, benefits of locally administered NSAIDs remain unclear outside the field of ophthalmologic surgery. Studies of local NSAID administration for postoperative analgesia vary considerably in terms of dosing and methodologic quality, making... περισσότερα »

Functional imaging in liver tumours.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Functional imaging in liver tumours.* J Hepatol. 2016 Jul 6; Authors: Ronot M, Clift AK, Vilgrain V, Frilling A Abstract Functional imaging encompasses techniques capable of assessing physiological parameters of tissues, and offers useful clinical information in addition to that obtained from morphological imaging. Such techniques may include magnetic resonance imaging with diffusion-weighted sequences or hepatobiliary contrast agents, perfusion imaging, or molecular imaging with radiolabelled tracers. The liver is of major importance in oncological practice; not only is hepatoc... περισσότερα »

Salivary Gland. Photon beam and particle radiotherapy: Present and future.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Salivary Gland. Photon beam and particle radiotherapy: Present and future.* Oral Oncol. 2016 Jul 6; Authors: Orlandi E, Iacovelli NA, Bonora M, Cavallo A, Fossati P Abstract Salivary gland cancers (SGCs) are rare diseases and their treatment depends upon histology, stage and site of origin. Radical surgery is the mainstay of treatment but radiotherapy (RT) plays a key role in both the postoperative and the inoperable setting, as well as in recurrent disease. In the absence of prospective randomized trials, a wide retrospective literature suggests postoperative RT (PORT) in patien... περισσότερα »

DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 7 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Roser Vento-Tormo, Damiana Álvarez-Errico, Antonio Garcia-Gomez, José Hernández-Rodríguez, Segundo Buján, Maria Basagaña, Maria Méndez, Jordi Yagüe, Manel Juan, Juan I. Aróstegui, Esteban Ballestar BackgroundInflammasomes are cytosolic multiprotein complexes in macrophages. They assemble after infection- or stress-associated stimuli, activating both caspase-1–mediated inflammatory cytokine secretion and pyroptosis. Increased inflammasome activity resulting from gene mutations ... περισσότερα »

TPL-2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 5 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Yashaswini Kannan, Yanda Li, Stephanie M. Coomes, Isobel S. Okoye, Victoria S. Pelly, Srividya Sriskantharajah, Eva Gückel, Lauren Webb, Stephanie Czieso, Nikolay Nikolov, Andrew S. MacDonald, Steven C. Ley, Mark S. Wilson BackgroundThe molecular and cellular pathways driving the pathogenesis of severe asthma are poorly defined. TPL-2 (COT, MAP3K8) kinase activates the MEK1/2-ERK1/2 MAP kinase signaling pathway following TLR, TNFR1 and IL-1R stimulation.ObjectiveTPL-2 has been... περισσότερα »

No evidence of large genetic effects on steroid response in asthma patients

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 5 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Michael Mosteller, Louise Hosking, Kay Murphy, Judong Shen, Kijoung Song, Matthew Nelson, Soumitra Ghosh BackgroundInhaled corticosteroids (ICS) are considered the most effective anti-inflammatory therapy for asthma control and management; however, there is substantial treatment response variability.ObjectiveTo identify genetic markers of ICS response by conducting the largest pharmacogenetic investigation to date in 2672 ICS-treated asthmatic patients.MethodsGenotyping and im... περισσότερα »

Relationships Among Aeroallergen Sensitization, Peripheral Blood Eosinophils and Periostin in Pediatric Asthma Development

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 5 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Halie M. Anderson, Robert F. Lemanske, Joseph R. Arron, Cecile T.J. Holweg, Victoria Rajamanickam, Ronald E. Gangnon, James E. Gern, Daniel J. Jackson BackgroundBiomarkers, preferably non-invasive, that predict asthma inception children are lacking.ObjectiveLittle is known about biomarkers of type 2 inflammation in early life in relation to asthma inception. We evaluated aeroallergen sensitization, peripheral blood eosinophils and serum periostin as potential biomarkers of ast... περισσότερα »

Transcriptional profiling identifies the lncRNA PVT1 as a novel regulator of the asthmatic phenotype in human airway smooth muscle

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 2 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Philip J. Austin, Eleni Tsitsiou, Charlotte Boardman, Simon W. Jones, Mark A. Lindsay, Ian M. Adcock, Kian Fan Chung, Mark M. Perry BackgroundThe mechanism underlying non-severe and severe asthma remains unclear although it is commonly associated with increased airway smooth muscle (ASM) mass. Long non-coding RNAs (lncRNAs) are known to be important in regulating healthy primary ASM cells whilst changed expression has been observed in CD8 T-cells from patients with severe asthm... περισσότερα »

Early thymectomy leads to premature immunologic ageing: An 18-year follow-up

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 7 July 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Judith Gudmundsdottir, Sólveig Óskarsdóttir, Gabriel Skogberg, Susanne Lindgren, Vanja Lundberg, Martin Berglund, Anna-Carin Lundell, Håkan Berggren, Anders Fasth, Esbjörn Telemo, Olov Ekwall http://ift.tt/29OWd6N

Peripheral blood gene expression predicts clinical benefit from anti-IL-13 in asthma

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 29 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): David F. Choy, Guiquan Jia, Alexander R. Abbas, Katrina B. Morshead, Nicholas Lewin-Koh, Rajiv Dua, Pauline Rivera, Priscilla Moonsamy, Marcel Fontecha, Aarthi Balasubramanyam, Chris Santini, Ekaterina Bassett, Jill M. Ray, Christopher R. Cabanski, Mary S. Bradley, Romeo Maciuca, Sofia Mosesova, Heleen Scheerens, Joseph R. Arron Blood gene expression corresponds to eosinophilic airway inflammation and predicts clinical response to anti-IL-13 in asthma and therefore may be a u... περισσότερα »

The skin microbiome is different in pediatric versus adult atopic dermatitis

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 29 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Baochen Shi, Nathanael J. Bangayan, Emily Curd, Patricia A. Taylor, Richard L. Gallo, Donald Y.M. Leung, Huiying Li TeaserMicrobiome analysis of 324 skin samples from 128 AD patients and 68 healthy controls revealed age differences in the microbiome, suggesting that the skin microbiota may play different roles in pediatric and adult AD. http://ift.tt/29OWaIc

Ectodermal dysplasia with immunodeficiency caused by a branch-point mutation in IKBKG/NEMO

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 29 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Sofie E. Jørgensen, Pernille Bøttger, Emil Kofod-Olsen, Mette Holm, Nanna Mørk, Torben F. Ørntoft, Uffe B.S. Sørensen, Jens Magnus Bernth-Jensen, Troels Herlin, Jens Veirum, Carsten S. Larsen, Lars Østergaard, Rune Hartmann, Mette Christiansen, Trine H. Mogensen TeaserHere we identify a novel genetic mechanism of ectodermal dysplasia with immunodeficiency caused by an intronic branch-point mutation in NEMO/IKBKG leading to mis-splicing of transcripts and absence of NEMO prot... περισσότερα »

Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 29 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Odelya E. Pagovich, Bo Wang, Maria J. Chiuchiolo, Stephen M. Kaminsky, Dolan Sondhi, Clarisse L. Jose, Christina C. Price, Sarah F. Brooks, Jason G. Mezey, Ronald G. Crystal BackgroundPeanuts are the most common food to provoke fatal or near-fatal anaphylactic reactions. Treatment with an anti-hIgE mAb is efficacious but requires frequent parenteral administration.ObjectiveBased on the knowledge that peanut allergy is mediated by peanut-specific IgE, we hypothesized that a si... περισσότερα »

Antihistamine updosing reduces disease activity in difficult-to-treat cholinergic urticaria patients

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 29 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): K. Wosny, K. Weller, A. Werner, M. Maurer, S. Altrichter http://ift.tt/29OVN0j

Separating Sensitization and Regulatory T Cell Functions in Food Allergy

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 29 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Kathryn E. Hulse http://ift.tt/29IEvPL

Complete human CD1a deficiency on Langerhans cells due to a rare point mutation in the coding sequence

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 29 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Daniela Cerny, Duyen Huynh Thi Le, Trung Dinh The, Roland Zuest, K.G. Srinivasan, Sumathy Velumani, Chiea Chuen Khor, Lucia Mori, Cameron P. Simmons, Michael Poidinger, Francesca Zolezzi, Florent Ginhoux, Muzlifah Haniffa, Bridget Wills, Katja Fink http://ift.tt/29OVWkq

Assessing the Impact of Engineered Nanomaterials on the Environment and Human Health

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 27 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Sean M. Geary, Angie S. Morris, Aliasger K. Salem http://ift.tt/29IEmvG

Asthma and the Olympics

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 23 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Kai-Håkon Carlsen, Karin C. Lødrup Carlsen http://ift.tt/29OVRx1

Dendritic cell targeting using C-type lectins for the improvement of allergen immunotherapy

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 23 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Stefan Schülke, Stefan Vieths http://ift.tt/29IEfQw

High alcohol consumption causes high IgE levels, but not high risk of allergic disease

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 23 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Frederikke K. Lomholt, Sune F. Nielsen, Børge G. Nordestgaard BackgroundHigh alcohol consumption is associated with high IgE levels in observational studies; however, whether high alcohol consumption leads to high IgE levels and allergic disease is unclear.ObjectiveWe tested the hypothesis that high alcohol consumption is associated with high IgE levels and with allergic disease, observationally and genetically using a Mendelian randomization design free of reverse causation a... περισσότερα »

Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure - the EGEA study

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 22 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Valérie Siroux, Christian Lupinek, Yvonne Resch, Mirela Curin, Jocelyne Just, Thomas Keil, Renata Kiss, Karin Lodrup Carlsen, Erik Melén, Rachel Nadif, Isabelle Pin, Ingebjørg Skrindo, Susanne Vrtala, Magnus Wickman, Josep Maria Anto, Rudolf Valenta, Jean Bousquet BackgroundThe nature of allergens, route and dose of exposure may affect the natural development of IgE and IgG responses.AimTo investigate the natural IgE and IgG responses towards a large panel of respiratory and f... περισσότερα »

Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
Publication date: Available online 22 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Gyohei Egawa, Kenji Kabashima Atopic dermatitis (AD) is the most common inflammatory skin disease in the industrialized world, and has multiple etiologies. Over the past decade, data from both experimental models and patients have highlighted the primary pathogenic role of skin barrier deficiency in AD. Increased access of environmental agents into the skin results in chronic inflammation and contributes to the systemic “atopic (allergic) march”. In addition, persistent skin ... περισσότερα »

Adult but no pediatric anaphylaxis-related deaths in the Finnish population from 1996 to 2013

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 21 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Juho E. Kivistö, Teija Dunder, Jennifer L.P. Protudjer, Jussi Karjalainen, Heini Huhtala, Mika J. Mäkelä http://ift.tt/2a1Gluk

Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.* Eur Arch Otorhinolaryngol. 2016 Jul 9; Authors: Su CH, Lee KS, Tseng TM, Tseng H, Ding YF, Koch M, Hung SH Abstract While conservative approaches for chronic sialoadenitis are in current use, the utility of intraductal injection therapy remains unclear. The purpose of this study is to provide evidence that substances delivered through intraductal injection of the salivary gland are able to be effectively distributed throughout the gland. Methylene blue dye (0.1 %) was injected... περισσότερα »

Autophagy and Immune Senescence.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Autophagy and Immune Senescence.* Trends Mol Med. 2016 Jul 6; Authors: Zhang H, Puleston DJ, Simon AK Abstract With extension of the average lifespan, aging has become a heavy burden in society. Immune senescence is a key risk factor for many age-related diseases such as cancer and increased infections in the elderly, and hence has elicited much attention in recent years. As our body's guardian, the immune system maintains systemic health through removal of pathogens and damage. Autophagy is an important cellular 'clearance' process by which a cell internally delivers damaged or... περισσότερα »

Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival.* Eur J Intern Med. 2016 Jul 7; Authors: Kanbay M, Afsar B, Siriopol D, Unal HU, Karaman M, Saglam M, Gezer M, Taş A, Eyileten T, Guler AK, Aydin İ, Oguz Y, Tarim K, Covic A, Yilmaz MI Abstract BACKGROUND AND AIMS: Endostatin, generated from collagen XVIII, and endorepellin, possess dual activity as modifiers of both angiogenesis and endothelial cell autophagy. Plasma endostatin levels are elevated in a large number of diseases, and may reflect endothel... περισσότερα »

Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment.* Free Radic Biol Med. 2016 Jul 6; Authors: Bodas M, Van Westphal C, Carpenter-Thompson R, Mohanty D, Vij N Abstract Waterpipe smoking and e-cigarette vaping, the non-combustible sources of inhaled nicotine exposure are increasingly becoming popular and marketed as safer alternative to cigarette smoking. Hence, this study was designed to investigate the impact of inhaled nicotine exposure on disease causing COPD-emphysema mechanisms. For in vitro studies, human bronc... περισσότερα »

Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.* Eur Arch Otorhinolaryngol. 2016 Jul 9; Authors: Su CH, Lee KS, Tseng TM, Tseng H, Ding YF, Koch M, Hung SH Abstract While conservative approaches for chronic sialoadenitis are in current use, the utility of intraductal injection therapy remains unclear. The purpose of this study is to provide evidence that substances delivered through intraductal injection of the salivary gland are able to be effectively distributed throughout the gland. Methylene blue dye (0.1 %) was injected... περισσότερα »

Myeloid Sarcoma: Presenting with Massive Cervical and Inguinal Lymphadenopathy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Myeloid Sarcoma: Presenting with Massive Cervical and Inguinal Lymphadenopathy.* Head Neck Pathol. 2016 Jul 9; Authors: Walsh JC, Arnold MG, Mohtashamian A Abstract A 21 year old Active Duty Marine presented with acute onset of diffuse lymphadenopathy and B-symptoms. Biopsy was conducted which demonstrated myeloid sarcoma. Myeloid sarcoma is diagnostic for AML but is only present in 2-8 % of patients with AML. Our article presents a classic presentation and histologic appearance and discusses the current status of the literature. PMID: 27395055 [PubMed - as supplied by publishe... περισσότερα »

A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.* Hormones (Athens). 2016 Jul 11; Authors: Neocleous V, Shammas C, Phelan MM, Fanis P, Pantelidou M, Skordis N, Mantzoros C, Phylactou LA, Toumba M Abstract OBJECTIVE: Heterozygous mutations on the melanocortin-4-receptor gene (MC4R) are the most frequent cause of monogenic obesity. We describe a novel MC4R deletion in a girl with severe early onset obesity, tall stature, pale skin and red hair. CASE REPORT: Clinical and hormonal parameters were evaluated in a girl born full-term ... περισσότερα »

Development and validation of an osteoporosis treatment questionnaire (OSTREQ) evaluating physicians' criteria in the choice of treatment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Development and validation of an osteoporosis treatment questionnaire (OSTREQ) evaluating physicians' criteria in the choice of treatment.* Hormones (Athens). 2016 Jul 11; Authors: Makras P, Galanos A, Rizou S, Anastasilakis AD, Lyritis GP Abstract OBJECTIVE: This article describes the development and validation of the osteoporosis treatment questionnaire (OSTREQ), which is a physician-reported outcome tool aiming to evaluate physicians' criteria in the choice of osteoporosis treatment. DESIGN: The questionnaire -named OSTREQ- consisting of 17 questions that were divided into eig... περισσότερα »

Bone mineral status and metabolism in patients with Williams-Beuren syndrome.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Bone mineral status and metabolism in patients with Williams-Beuren syndrome.* Hormones (Athens). 2016 Jul 11; Authors: Stagi S, Manoni C, Scalini P, Chiarelli F, Verrotti A, Cecchi C, Lapi E, Giglio S, Romano S, de Martino M Abstract OBJECTIVE: To evaluate bone mineral status and metabolism in a cohort of patients with Williams-Beuren syndrome (WBS). PATIENTS: Thirty-one children (15 females, 16 males; mean age 9.6±2.74 years) and 10 young adults (6 females, 4 males; mean age 21.4±5.11 years) with WBS were cross-sectionally evaluated and compared with two age-, sex-, and body-s... περισσότερα »

Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.* Lasers Med Sci. 2016 Jul 9; Authors: Choi SY, Oh CT, Kwon TR, Kwon HJ, Choi EJ, Jang YJ, Kim HS, Chu H, Mun SK, Kim MN, Kim BJ Abstract Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) w... περισσότερα »

Live virus vaccines based on a vesicular stomatitis virus (VSV) backbone: Standardized template with key considerations for a risk/benefit assessment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Live virus vaccines based on a vesicular stomatitis virus (VSV) backbone: Standardized template with key considerations for a risk/benefit assessment.* Vaccine. 2016 Jul 6; Authors: Clarke DK, Hendry RM, Singh V, Rose JK, Seligman SJ, Klug B, Kochhar S, Mac LM, Carbery B, Chen RT, Brighton Collaboration Viral Vector Vaccines Safety Working Group Abstract The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety of live, recombinant viral vaccines incorporating genes from heterologous viral and other microbial pathogens in th... περισσότερα »

Esophageal remnant cancer 35 years after acidic caustic injury: A case report.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Esophageal remnant cancer 35 years after acidic caustic injury: A case report.* Int J Surg Case Rep. 2016 Jul 1;25:215-217 Authors: Ntanasis-Stathopoulos I, Triantafyllou S, Xiromeritou V, Bliouras N, Loizou C, Theodorou D Abstract INTRODUCTION: Esophageal squamous cell carcinoma has been described as a long-term consequence following ingestion of corrosive substances. PRESENTATION OF CASE: We report a rare case of a 62-year-old female patient with a history of acidic caustic injury 35 years ago, for which she had undergone near total esophagogastrectomy with right colon interpos... περισσότερα »

Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.* Eur Arch Otorhinolaryngol. 2016 Jul 9; Authors: Su CH, Lee KS, Tseng TM, Tseng H, Ding YF, Koch M, Hung SH Abstract While conservative approaches for chronic sialoadenitis are in current use, the utility of intraductal injection therapy remains unclear. The purpose of this study is to provide evidence that substances delivered through intraductal injection of the salivary gland are able to be effectively distributed throughout the gland. Methylene blue dye (0.1 %) was injected... περισσότερα »

Myeloid Sarcoma: Presenting with Massive Cervical and Inguinal Lymphadenopathy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Myeloid Sarcoma: Presenting with Massive Cervical and Inguinal Lymphadenopathy.* Head Neck Pathol. 2016 Jul 9; Authors: Walsh JC, Arnold MG, Mohtashamian A Abstract A 21 year old Active Duty Marine presented with acute onset of diffuse lymphadenopathy and B-symptoms. Biopsy was conducted which demonstrated myeloid sarcoma. Myeloid sarcoma is diagnostic for AML but is only present in 2-8 % of patients with AML. Our article presents a classic presentation and histologic appearance and discusses the current status of the literature. PMID: 27395055 [PubMed - as supplied by publishe... περισσότερα »

Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.* Lasers Med Sci. 2016 Jul 9; Authors: Choi SY, Oh CT, Kwon TR, Kwon HJ, Choi EJ, Jang YJ, Kim HS, Chu H, Mun SK, Kim MN, Kim BJ Abstract Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) w... περισσότερα »

Salivary Gland. Photon beam and particle radiotherapy: Present and future.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Salivary Gland. Photon beam and particle radiotherapy: Present and future.* Oral Oncol. 2016 Jul 6; Authors: Orlandi E, Iacovelli NA, Bonora M, Cavallo A, Fossati P Abstract Salivary gland cancers (SGCs) are rare diseases and their treatment depends upon histology, stage and site of origin. Radical surgery is the mainstay of treatment but radiotherapy (RT) plays a key role in both the postoperative and the inoperable setting, as well as in recurrent disease. In the absence of prospective randomized trials, a wide retrospective literature suggests postoperative RT (PORT) in patien... περισσότερα »

Live virus vaccines based on a vesicular stomatitis virus (VSV) backbone: Standardized template with key considerations for a risk/benefit assessment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Live virus vaccines based on a vesicular stomatitis virus (VSV) backbone: Standardized template with key considerations for a risk/benefit assessment.* Vaccine. 2016 Jul 6; Authors: Clarke DK, Hendry RM, Singh V, Rose JK, Seligman SJ, Klug B, Kochhar S, Mac LM, Carbery B, Chen RT, Brighton Collaboration Viral Vector Vaccines Safety Working Group Abstract The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety of live, recombinant viral vaccines incorporating genes from heterologous viral and other microbial pathogens in th... περισσότερα »

Esophageal remnant cancer 35 years after acidic caustic injury: A case report.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Esophageal remnant cancer 35 years after acidic caustic injury: A case report.* Int J Surg Case Rep. 2016 Jul 1;25:215-217 Authors: Ntanasis-Stathopoulos I, Triantafyllou S, Xiromeritou V, Bliouras N, Loizou C, Theodorou D Abstract INTRODUCTION: Esophageal squamous cell carcinoma has been described as a long-term consequence following ingestion of corrosive substances. PRESENTATION OF CASE: We report a rare case of a 62-year-old female patient with a history of acidic caustic injury 35 years ago, for which she had undergone near total esophagogastrectomy with right colon interpos... περισσότερα »

Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG.* Hormones (Athens). 2016 Jul 11; Authors: Gezer E, Yurekli BŞ, Kocabas3 GU PMID: 27394710 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29yLY3f via IFTTT

Salivary Gland. Photon beam and particle radiotherapy: Present and future.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Salivary Gland. Photon beam and particle radiotherapy: Present and future.* Oral Oncol. 2016 Jul 6; Authors: Orlandi E, Iacovelli NA, Bonora M, Cavallo A, Fossati P Abstract Salivary gland cancers (SGCs) are rare diseases and their treatment depends upon histology, stage and site of origin. Radical surgery is the mainstay of treatment but radiotherapy (RT) plays a key role in both the postoperative and the inoperable setting, as well as in recurrent disease. In the absence of prospective randomized trials, a wide retrospective literature suggests postoperative RT (PORT) in patien... περισσότερα »

Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG.* Hormones (Athens). 2016 Jul 11; Authors: Gezer E, Yurekli BŞ, Kocabas3 GU PMID: 27394710 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29yLY3f

Cyclopes and Giants: From Homer's Odyssey to contemporary genetic diagnosis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Cyclopes and Giants: From Homer's Odyssey to contemporary genetic diagnosis.* Hormones (Athens). 2016 Jul 11; Authors: Markantes GK, Theodoropoulou A, Armeni AK, Vasileiou V, Stratakis CA, Georgopoulos NA PMID: 27394709 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29xvEnB via IFTTT

Cyclopes and Giants: From Homer's Odyssey to contemporary genetic diagnosis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Cyclopes and Giants: From Homer's Odyssey to contemporary genetic diagnosis.* Hormones (Athens). 2016 Jul 11; Authors: Markantes GK, Theodoropoulou A, Armeni AK, Vasileiou V, Stratakis CA, Georgopoulos NA PMID: 27394709 [PubMed - as supplied by publisher] from Head and Neck on PubMed via xlomafota13 on Inoreader http://ift.tt/29xvEnB

A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.* Hormones (Athens). 2016 Jul 11; Authors: Neocleous V, Shammas C, Phelan MM, Fanis P, Pantelidou M, Skordis N, Mantzoros C, Phylactou LA, Toumba M Abstract OBJECTIVE: Heterozygous mutations on the melanocortin-4-receptor gene (MC4R) are the most frequent cause of monogenic obesity. We describe a novel MC4R deletion in a girl with severe early onset obesity, tall stature, pale skin and red hair. CASE REPORT: Clinical and hormonal parameters were evaluated in a girl born full-term ... περισσότερα »

Cabergoline treatment for recurrent Cushing's disease during pregnancy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Cabergoline treatment for recurrent Cushing's disease during pregnancy.* Hormones (Athens). 2016 Jul 11; Authors: Nakhleh A, Saiegh L, Reut M, Ahmad MS, Pearl IW, Shechner C Abstract OBJECTIVE: Cushing`s disease during pregnancy is associated with an increased risk for maternal and fetal complications. In recurrent Cushing`s disease following transsphenoidal surgery, and when re-operation is not feasible, medical treatment is usually considered. Cabergoline was found to be effective in reducing hypercortisolism in Cushing's disease. Evolving data concerning the safety of cabergol... περισσότερα »

Development and validation of an osteoporosis treatment questionnaire (OSTREQ) evaluating physicians' criteria in the choice of treatment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 48 δευτερόλεπτα
*Development and validation of an osteoporosis treatment questionnaire (OSTREQ) evaluating physicians' criteria in the choice of treatment.* Hormones (Athens). 2016 Jul 11; Authors: Makras P, Galanos A, Rizou S, Anastasilakis AD, Lyritis GP Abstract OBJECTIVE: This article describes the development and validation of the osteoporosis treatment questionnaire (OSTREQ), which is a physician-reported outcome tool aiming to evaluate physicians' criteria in the choice of osteoporosis treatment. DESIGN: The questionnaire -named OSTREQ- consisting of 17 questions that were divided into eig... περισσότερα »

Experimental study on penetration of dental implants into the maxillary sinus at different depths.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Experimental study on penetration of dental implants into the maxillary sinus at different depths.* Oral Maxillofac Surg. 2016 Jul 9; Authors: Elhamruni LM, Marzook HA, Ahmed WM, Abdul-Rahman M Abstract OBJECTIVE: The purpose of this study was to investigate the effect of the dental implant penetration into the maxillary sinus cavity in different depths on implant and sinus health in a dog model. MATERIALS AND METHODS: The study sample included eight titanium dental implant placed in four female dogs immediately after extraction of the first maxillary molar in the palatal socket ... περισσότερα »

Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Prenatal exposure to perfluorinated compounds affects thyroid hormone levels in newborn girls.* Environ Int. 2016 Jul 6; Authors: Shah-Kulkarni S, Kim BM, Hong YC, Kim HS, Kwon EJ, Park H, Kim YJ, Ha EH Abstract Perfluorinated compounds (PFCs) are ubiquitous in the environment and have been detected in humans and wildlife. Exposure to PFCs has decreased in the United States recently, while exposure to PFCs continues in Asian countries, which represents a public health concern. Various mechanisms by which PFCs affect fetal growth have been proposed, such as activation of peroxis... περισσότερα »

Ratio of intra-operative fluid to anesthesia time and its impact on short term perioperative outcomes following gastrectomy for cancer: a retrospective cohort study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Ratio of intra-operative fluid to anesthesia time and its impact on short term perioperative outcomes following gastrectomy for cancer: a retrospective cohort study.* Int J Surg. 2016 Jul 6; Authors: Enomoto LM, Blackham A, Woo Y, Yamamoto M, Pimiento J, Gusani NJ, Wong J Abstract BACKGROUND: This study evaluates the short-term impact of fluid administration during gastrectomy for cancer. METHODS: A multi-institutional database of patients undergoing gastrectomy for cancer from three tertiary centers was reviewed. Logistic and linear regression analyses were performed. RESULTS: ... περισσότερα »

Multimodal Analgesia: A systematic review of local NSAIDs for non-ophthalmologic postoperative pain management.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Multimodal Analgesia: A systematic review of local NSAIDs for non-ophthalmologic postoperative pain management.* Int J Surg. 2016 Jul 6; Authors: Brubaker L, Kendall L, Reina E Abstract INTRODUCTION: While the analgesic benefits of systemically administered non-steroidal anti-inflammatory drugs (NSAIDs) for postoperative pain are well established, benefits of locally administered NSAIDs remain unclear outside the field of ophthalmologic surgery. Studies of local NSAID administration for postoperative analgesia vary considerably in terms of dosing and methodologic quality, making... περισσότερα »

Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Predictive factors for the appearance of myringosclerosis after myringotomy with ventilation tube placement: randomized study.* Eur Arch Otorhinolaryngol. 2016 Jul 9; Authors: Branco C, Monteiro D, Paço J Abstract Myringotomy with the insertion of ventilation tubes is the most frequent surgical procedure performed in children, and the appearance of myringosclerosis is one of its most frequent long-term complications. The objective of this study is to identify clinical factors and technique variations that may have a relation with the appearance of myringosclerosis, after tube in... περισσότερα »

Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.* Eur Arch Otorhinolaryngol. 2016 Jul 9; Authors: Su CH, Lee KS, Tseng TM, Tseng H, Ding YF, Koch M, Hung SH Abstract While conservative approaches for chronic sialoadenitis are in current use, the utility of intraductal injection therapy remains unclear. The purpose of this study is to provide evidence that substances delivered through intraductal injection of the salivary gland are able to be effectively distributed throughout the gland. Methylene blue dye (0.1 %) was injected... περισσότερα »

Functional inhibition of Hsp70 by Pifithrin-μ switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Functional inhibition of Hsp70 by Pifithrin-μ switches Gambogic acid induced caspase dependent cell death to caspase independent cell death in human bladder cancer cells.* Biochim Biophys Acta. 2016 Jul 6; Authors: Ishaq M, Ojha R, Sharma K, Sharma G, Singh SK, Majumdar S Abstract Heat shock protein-70kDa (Hsp70) is a member of molecular chaperone family, involved in the proper folding of various proteins. Hsp70 is important for tumor cell survival and is also reported to be involved in enhancing the drug resistance of various cancer types. Hsp70 controls apoptosis both upstream... περισσότερα »

Histomorphometric and transcriptomic features characterize silk glands' development during the molt to intermolt transition process in silkworm.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Histomorphometric and transcriptomic features characterize silk glands' development during the molt to intermolt transition process in silkworm.* Insect Biochem Mol Biol. 2016 Jul 6; Authors: Hu W, Liu C, Cheng T, Li W, Wang N, Xia Q Abstract The molt-intermolt cycle is an essential feature in holometabolous and hemimetabolous insects' development. In the silkworm, silk glands are under dramatic morphological and functional changes with fibroin genes' transcription being repeatedly turned off and on during the molt-intermolt cycles. However, the molecular mechanisms controlling i... περισσότερα »

Autophagy and Immune Senescence.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Autophagy and Immune Senescence.* Trends Mol Med. 2016 Jul 6; Authors: Zhang H, Puleston DJ, Simon AK Abstract With extension of the average lifespan, aging has become a heavy burden in society. Immune senescence is a key risk factor for many age-related diseases such as cancer and increased infections in the elderly, and hence has elicited much attention in recent years. As our body's guardian, the immune system maintains systemic health through removal of pathogens and damage. Autophagy is an important cellular 'clearance' process by which a cell internally delivers damaged or... περισσότερα »

Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Endostatin in chronic kidney disease: Associations with inflammation, vascular abnormalities, cardiovascular events and survival.* Eur J Intern Med. 2016 Jul 7; Authors: Kanbay M, Afsar B, Siriopol D, Unal HU, Karaman M, Saglam M, Gezer M, Taş A, Eyileten T, Guler AK, Aydin İ, Oguz Y, Tarim K, Covic A, Yilmaz MI Abstract BACKGROUND AND AIMS: Endostatin, generated from collagen XVIII, and endorepellin, possess dual activity as modifiers of both angiogenesis and endothelial cell autophagy. Plasma endostatin levels are elevated in a large number of diseases, and may reflect endothel... περισσότερα »

Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Nicotine exposure induces bronchial epithelial cell apoptosis and senescence via ROS mediated autophagy-impairment.* Free Radic Biol Med. 2016 Jul 6; Authors: Bodas M, Van Westphal C, Carpenter-Thompson R, Mohanty D, Vij N Abstract Waterpipe smoking and e-cigarette vaping, the non-combustible sources of inhaled nicotine exposure are increasingly becoming popular and marketed as safer alternative to cigarette smoking. Hence, this study was designed to investigate the impact of inhaled nicotine exposure on disease causing COPD-emphysema mechanisms. For in vitro studies, human bronc... περισσότερα »

Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Intraductal injection as an effective drug delivery route in the management of salivary gland diseases.* Eur Arch Otorhinolaryngol. 2016 Jul 9; Authors: Su CH, Lee KS, Tseng TM, Tseng H, Ding YF, Koch M, Hung SH Abstract While conservative approaches for chronic sialoadenitis are in current use, the utility of intraductal injection therapy remains unclear. The purpose of this study is to provide evidence that substances delivered through intraductal injection of the salivary gland are able to be effectively distributed throughout the gland. Methylene blue dye (0.1 %) was injected... περισσότερα »

Myeloid Sarcoma: Presenting with Massive Cervical and Inguinal Lymphadenopathy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Myeloid Sarcoma: Presenting with Massive Cervical and Inguinal Lymphadenopathy.* Head Neck Pathol. 2016 Jul 9; Authors: Walsh JC, Arnold MG, Mohtashamian A Abstract A 21 year old Active Duty Marine presented with acute onset of diffuse lymphadenopathy and B-symptoms. Biopsy was conducted which demonstrated myeloid sarcoma. Myeloid sarcoma is diagnostic for AML but is only present in 2-8 % of patients with AML. Our article presents a classic presentation and histologic appearance and discusses the current status of the literature. PMID: 27395055 [PubMed - as supplied by publishe... περισσότερα »

Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Gain-switched 311-nm Ti:Sapphire laser might be a potential treatment modality for atopic dermatitis.* Lasers Med Sci. 2016 Jul 9; Authors: Choi SY, Oh CT, Kwon TR, Kwon HJ, Choi EJ, Jang YJ, Kim HS, Chu H, Mun SK, Kim MN, Kim BJ Abstract Phototherapy with 311-nm narrowband-UVB (NBUVB) is an effective adjuvant treatment modality for atopic dermatitis (AD). In this study, we evaluated the therapeutic effect of the newly developed gain-switched 311-nm Ti:Sapphire laser device using a NC/Nga mouse AD model. A total number of 50 mice were used in this study. Atopic dermatitis (AD) w... περισσότερα »

Live virus vaccines based on a vesicular stomatitis virus (VSV) backbone: Standardized template with key considerations for a risk/benefit assessment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Live virus vaccines based on a vesicular stomatitis virus (VSV) backbone: Standardized template with key considerations for a risk/benefit assessment.* Vaccine. 2016 Jul 6; Authors: Clarke DK, Hendry RM, Singh V, Rose JK, Seligman SJ, Klug B, Kochhar S, Mac LM, Carbery B, Chen RT, Brighton Collaboration Viral Vector Vaccines Safety Working Group Abstract The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety of live, recombinant viral vaccines incorporating genes from heterologous viral and other microbial pathogens in th... περισσότερα »

Esophageal remnant cancer 35 years after acidic caustic injury: A case report.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Esophageal remnant cancer 35 years after acidic caustic injury: A case report.* Int J Surg Case Rep. 2016 Jul 1;25:215-217 Authors: Ntanasis-Stathopoulos I, Triantafyllou S, Xiromeritou V, Bliouras N, Loizou C, Theodorou D Abstract INTRODUCTION: Esophageal squamous cell carcinoma has been described as a long-term consequence following ingestion of corrosive substances. PRESENTATION OF CASE: We report a rare case of a 62-year-old female patient with a history of acidic caustic injury 35 years ago, for which she had undergone near total esophagogastrectomy with right colon interpos... περισσότερα »

Salivary Gland. Photon beam and particle radiotherapy: Present and future.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Salivary Gland. Photon beam and particle radiotherapy: Present and future.* Oral Oncol. 2016 Jul 6; Authors: Orlandi E, Iacovelli NA, Bonora M, Cavallo A, Fossati P Abstract Salivary gland cancers (SGCs) are rare diseases and their treatment depends upon histology, stage and site of origin. Radical surgery is the mainstay of treatment but radiotherapy (RT) plays a key role in both the postoperative and the inoperable setting, as well as in recurrent disease. In the absence of prospective randomized trials, a wide retrospective literature suggests postoperative RT (PORT) in patien... περισσότερα »

Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Thyrotoxic hypokalemic periodic paralysis in a Turkish patient presenting with a U wave on ECG.* Hormones (Athens). 2016 Jul 11; Authors: Gezer E, Yurekli BŞ, Kocabas3 GU PMID: 27394710 [PubMed - as supplied by publisher] http://ift.tt/29yLY3f

Cyclopes and Giants: From Homer's Odyssey to contemporary genetic diagnosis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Cyclopes and Giants: From Homer's Odyssey to contemporary genetic diagnosis.* Hormones (Athens). 2016 Jul 11; Authors: Markantes GK, Theodoropoulou A, Armeni AK, Vasileiou V, Stratakis CA, Georgopoulos NA PMID: 27394709 [PubMed - as supplied by publisher] http://ift.tt/29xvEnB

A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*A novel MC4R deletion coexisting with FTO and MC1R gene variants, causes severe early onset obesity.* Hormones (Athens). 2016 Jul 11; Authors: Neocleous V, Shammas C, Phelan MM, Fanis P, Pantelidou M, Skordis N, Mantzoros C, Phylactou LA, Toumba M Abstract OBJECTIVE: Heterozygous mutations on the melanocortin-4-receptor gene (MC4R) are the most frequent cause of monogenic obesity. We describe a novel MC4R deletion in a girl with severe early onset obesity, tall stature, pale skin and red hair. CASE REPORT: Clinical and hormonal parameters were evaluated in a girl born full-term ... περισσότερα »

Cabergoline treatment for recurrent Cushing's disease during pregnancy.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Cabergoline treatment for recurrent Cushing's disease during pregnancy.* Hormones (Athens). 2016 Jul 11; Authors: Nakhleh A, Saiegh L, Reut M, Ahmad MS, Pearl IW, Shechner C Abstract OBJECTIVE: Cushing`s disease during pregnancy is associated with an increased risk for maternal and fetal complications. In recurrent Cushing`s disease following transsphenoidal surgery, and when re-operation is not feasible, medical treatment is usually considered. Cabergoline was found to be effective in reducing hypercortisolism in Cushing's disease. Evolving data concerning the safety of cabergol... περισσότερα »

Development and validation of an osteoporosis treatment questionnaire (OSTREQ) evaluating physicians' criteria in the choice of treatment.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Development and validation of an osteoporosis treatment questionnaire (OSTREQ) evaluating physicians' criteria in the choice of treatment.* Hormones (Athens). 2016 Jul 11; Authors: Makras P, Galanos A, Rizou S, Anastasilakis AD, Lyritis GP Abstract OBJECTIVE: This article describes the development and validation of the osteoporosis treatment questionnaire (OSTREQ), which is a physician-reported outcome tool aiming to evaluate physicians' criteria in the choice of osteoporosis treatment. DESIGN: The questionnaire -named OSTREQ- consisting of 17 questions that were divided into eig... περισσότερα »

Bone mineral status and metabolism in patients with Williams-Beuren syndrome.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Bone mineral status and metabolism in patients with Williams-Beuren syndrome.* Hormones (Athens). 2016 Jul 11; Authors: Stagi S, Manoni C, Scalini P, Chiarelli F, Verrotti A, Cecchi C, Lapi E, Giglio S, Romano S, de Martino M Abstract OBJECTIVE: To evaluate bone mineral status and metabolism in a cohort of patients with Williams-Beuren syndrome (WBS). PATIENTS: Thirty-one children (15 females, 16 males; mean age 9.6±2.74 years) and 10 young adults (6 females, 4 males; mean age 21.4±5.11 years) with WBS were cross-sectionally evaluated and compared with two age-, sex-, and body-s... περισσότερα »

Validity and reliability of the Greek version of the Diabetic Foot Ulcer Scale - Short Form (DFS-SF).

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Validity and reliability of the Greek version of the Diabetic Foot Ulcer Scale - Short Form (DFS-SF).* Hormones (Athens). 2016 Jul 11; Authors: Kontodimopoulos N, Veniou A, Tentolouris N, Niakas D Abstract OBJECTIVE: Diabetic foot ulcer is a critical and costly complication of diabetes mellitus. The aim of this study was to assess the psychometric properties of the Greek version of the diabetic foot ulcer scale - short form (DFS-SF). DESIGN: A sample of patients with diabetic foot ulcer (N=110) was surveyed with the DFS-SF and various demographic and disease-related questions. Th... περισσότερα »

Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 49 δευτερόλεπτα
*Low vitamin D status is associated with hypothyroid Hashimoto's thyroiditis.* Hormones (Athens). 2016 Jul 11; Authors: Kim D Abstract OBJECTIVE: The association of low vitamin D status with autoimmune thyroid disease (AITD), which includes Hashimoto's thyroiditis (HT) and Graves' disease (GD), is controversial. The aim of this study was to investigate the correlation between vitamin D insufficiency and AITD, HT, and GD. DESIGN: Our cross-sectional study included patients who visited a tertiary hospital for thyroid evaluation or follow-up. A total of 776 patients in whom serum 25... περισσότερα »

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
*WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.* Ophthalmology. 2016 Jul 7; Authors: Grenier J, Meunier I, Daien V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP Abstract PURPOSE: To search for WFS1 mutations in patients with optic atrophy (OA) and assess visual impairment. DESIGN: Retrospective molecular genetic and clinical study. PARTICIPANTS: Patients with OA followed at a national referral center specialized in genetic sensory diseases. METHODS: Mutation sc... περισσότερα »

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity.

WFS1 in Optic Neuropathies: Mutation Findings in Nonsyndromic Optic Atrophy and Assessment of Clinical Severity. Ophthalmology. 2016 Jul 7; Authors: Grenier J, Meunier I, Daien V, Baudoin C, Halloy F, Bocquet B, Blanchet C, Delettre C, Esmenjaud E, Roubertie A, Lenaers G, Hamel CP Abstract PURPOSE: To search for WFS1 mutations in patients with optic […]

Separating Sensitization and Regulatory T Cell Functions in Food Allergy

Publication date: Available online 29 June 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Kathryn E. Hulse } http://ift.tt/29IEvPL

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