HMGB1 IS INCREASED BY CFTR LOSS OF FUNCTION, IS LOWERED BY INSULIN AND INCREASES IN VIVO AT ONSET OF CFRD.
*HMGB1 IS INCREASED BY CFTR LOSS OF FUNCTION, IS LOWERED BY INSULIN AND INCREASES IN VIVO AT ONSET OF CFRD.* J Clin Endocrinol Metab. 2016 Jan 13;:jc20153730 Authors: Montanini L, Cirillo F, Smerieri A, Pisi G, Giardino I, d'Apolito M, Spaggiari C, Bernasconi S, Amarri S, Street ME Abstract CONTEXT: Cystic Fibrosis-Related Diabetes (CFRD) is associated with worsening of inflammation and infections, and the beginning of insulin treatment is debated. OBJECTIVES: To verify HMGB1 levels in CF patients according to glucose tolerance state, and analyze relationships with insulin secret... περισσότερα »
JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects.
*JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects.* J Clin Endocrinol Metab. 2016 Jan 13;:jc20153403 Authors: de Filippis T, Marelli F, Nebbia G, Porazzi P, Corbetta S, Fugazzola L, Gastaldi R, Vigone MC, Biffanti R, Frizziero D, Mandarà L, Prontera P, Salerno M, Maghnie M, Tiso N, Radetti G, Weber G, Persani L Abstract CONTEXT: The pathogenesis of congenital hypothyroidism (CH) is still largely unexplained. We previously reported that perturbations of the Notch pathway and knockdown of the ligand jagged1 cause a hyp...περισσότερα »
HMGB1 IS INCREASED BY CFTR LOSS OF FUNCTION, IS LOWERED BY INSULIN AND INCREASES IN VIVO AT ONSET OF CFRD.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
HMGB1 IS INCREASED BY CFTR LOSS OF FUNCTION, IS LOWERED BY INSULIN AND INCREASES IN VIVO AT ONSET OF CFRD. J Clin Endocrinol Metab. 2016 Jan 13;:jc20153730 Authors: Montanini L, Cirillo F, Smerieri A, Pisi G, Giardino I, d’Apolito M, Spaggiari C, Bernasconi S, Amarri S, Street ME Abstract CONTEXT: Cystic Fibrosis-Related Diabetes (CFRD) is […]
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, […]
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, […]
The Function of Naringin in Inducing Secretion of Osteoprotegerin and Inhibiting Formation of Osteoclasts
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Osteoporosis has become one of the most prevalent and costly diseases in the world. It is a metabolic disease characterized by reduction in bone mass due to an imbalance between bone formation and resorption. Osteoporosis causes fractures, prolongs bone healing, and impedes osseointegration of dental implants. Its pathological features include osteopenia, degradation of bone tissue […]
IJMS, Vol. 17, Pages 90: Function and Regulation of Heterotrimeric G Proteins during Chemotaxis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Chemotaxis, or directional movement towards an extracellular gradient of chemicals, is necessary for processes as diverse as finding nutrients, the immune response, metastasis and wound healing. Activation of G-protein coupled receptors (GPCRs) is at the very base of the chemotactic signaling pathway. Chemotaxis starts with binding of the chemoattractant to GPCRs at the cell-surface, which […]
IJMS, Vol. 17, Pages 105: Urine Aquaporin-2: A Promising Marker of Response to the Arginine Vasopressin Type-2 Antagonist, Tolvaptan in Patients with Congestive Heart Failure
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the concentrating and diluting ability of the kidney. The arginine vasopressin type-2 antagonist, tolvaptan, is a new-generation diuretic; it is especially indicated in patients with decompensated heart failure refractory to conventional […]
IJMS, Vol. 17, Pages 102: Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
During the last few decades, improvements in the planning and application of radiotherapy in combination with surgery and chemotherapy resulted in increased survival rates of tumor patients. However, the success of radiotherapy is impaired by two reasons: firstly, the radioresistance of tumor cells and, secondly, the radiation-induced damage of normal tissue cells located in the […]
IJMS, Vol. 17, Pages 103: Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical […]
IJMS, Vol. 17, Pages 104: Fourier Transform Mass Spectrometry: The Transformation of Modern Environmental Analyses
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Unknown compounds in environmental samples are difficult to identify using standard mass spectrometric methods. Fourier transform mass spectrometry (FTMS) has revolutionized how environmental analyses are performed. With its unsurpassed mass accuracy, high resolution and sensitivity, researchers now have a tool for difficult and complex environmental analyses. Two features of FTMS are responsible for changing the […]
IJMS, Vol. 17, Pages 100: Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 7 δευτερόλεπτα
Iron is considered to play a key role in the development and progression of Multiple Sclerosis (MS). In particular, iron that accumulates in myeloid cells after the blood-brain barrier (BBB) seals may contribute to chronic inflammation, oxidative stress and eventually neurodegeneration. Magnetic resonance imaging (MRI) is a well-established tool for the non-invasive study of MS. […]
Practical Applications in Immunohistochemistry: Evaluation of Rejection and Infection in Organ Transplantation.
*Practical Applications in Immunohistochemistry: Evaluation of Rejection and Infection in Organ Transplantation.* Arch Pathol Lab Med. 2016 Jan 13; Authors: Troxell ML, Lanciault C Abstract Context .- Immunohistochemical analysis of tissue biopsy specimens is a crucial tool in diagnosis of both rejection and infection in patients with solid organ transplants. In the past 15 years, the concept of antibody-mediated rejection has been refined, and diagnostic criteria have been codified in renal, heart, pancreas, and lung allografts (with studies ongoing in liver, small intestine, a... περισσότερα »
IJMS, Vol. 17, Pages 100: Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Iron is considered to play a key role in the development and progression of Multiple Sclerosis (MS). In particular, iron that accumulates in myeloid cells after the blood-brain barrier (BBB) seals may contribute to chronic inflammation, oxidative stress and eventually neurodegeneration. Magnetic resonance imaging (MRI) is a well-established tool for the non-invasive study of MS. In recent years, an advanced MRI method, quantitative susceptibility mapping (QSM), has made it possible to study brain iron through in vivo imaging. Moreover, immunohistochemical investigations have helpe... περισσότερα »
IJMS, Vol. 17, Pages 107: Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Melanoma, one of the aggressive cancers, is known to be resistant to chemotherapy. Because of its aggressive nature, effectively inducing apoptosis is necessary to treat melanoma. Erythroid differentiation regulator 1 (Erdr1) is known to be a stress-related survival factor exhibiting anti-cancer effects in several cancers. However, little is known about the functions and underlying mechanisms of Erdr1 so far. To demonstrate the effect of Erdr1 in melanoma apoptosis, recombinant murine Erdr1 was injected into mice implanted with B16F10 melanoma cells. In vivo tumor growth was signi... περισσότερα »
Pretreatment lymphocyte to monocyte ratio as a predictor of prognosis in patients with early-stage triple-negative breast cancer
Abstract Recent studies have shown that the lymphocyte to monocyte ratio (LMR) is a useful prognostic factor in various cancers. The purpose of the current study was to investigate the association between pretreatment LMR, disease-free survival (DFS), and overall survival (OS) in patients with early-stage (I to III) triple-negative breast cancer (TNBC). Pretreatment LMR with corresponding clinical features from 230 TNBC patients was noted. A receiver operating characteristic (ROC) curve for survival prediction was plotted to verify the optimal cutoff values for LMR, lymphocyte, and...περισσότερα »
Protein arginine methyltransferase 1 interacts with Gli1 and regulates its transcriptional activity
Abstract Protein arginine methylation, which is mediated by the protein arginine methyltransferases (PRMTs), is associated with numerous fundamental cellular processes. Our previous studies have shown that PRMT1 activated Hedgehog signaling in the esophageal squamous cell carcinoma (ESCC) cells and promoted the growth and migration of cancer cells. However, the detailed mechanisms are unknown. In this study, it was found that PRMT1 interacted with the transcriptional factor Gli1 (glioma-associated oncogene homolog 1) in ESCC cells. The DNA-binding domain (DBD) of Gli1 is responsib...περισσότερα »
Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma
Abstract Cholangiocarcinoma (CCA) is a unique liver cancer subtype with an increasing incidence globally. The lack of specific symptoms and definite diagnostic markers results in a delayed diagnosis and disease progression. Systemic chemotherapy is commonly selected for advanced CCA even though its advantages remain unknown. Targeted therapy, especially anti-vascular endothelial growth factor (VEGF) therapy, is promising for CCA; however, improvements in the therapeutic regimen are necessary to overcome subsequent resistance. We demonstrated VEGF expression was higher in CCA cell ... περισσότερα »
IJMS, Vol. 17, Pages 104: Fourier Transform Mass Spectrometry: The Transformation of Modern Environmental Analyses
Unknown compounds in environmental samples are difficult to identify using standard mass spectrometric methods. Fourier transform mass spectrometry (FTMS) has revolutionized how environmental analyses are performed. With its unsurpassed mass accuracy, high resolution and sensitivity, researchers now have a tool for difficult and complex environmental analyses. Two features of FTMS are responsible for changing the face of how complex analyses are accomplished. First is the ability to quickly and with high mass accuracy determine the presence of unknown chemical residues in samples....περισσότερα »
IJMS, Vol. 17, Pages 100: Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping
Iron is considered to play a key role in the development and progression of Multiple Sclerosis (MS). In particular, iron that accumulates in myeloid cells after the blood-brain barrier (BBB) seals may contribute to chronic inflammation, oxidative stress and eventually neurodegeneration. Magnetic resonance imaging (MRI) is a well-established tool for the non-invasive study of MS. In recent years, an advanced MRI method, quantitative susceptibility mapping (QSM), has made it possible to study brain iron through in vivo imaging. Moreover, immunohistochemical investigations have helpe... περισσότερα »
IJMS, Vol. 17, Pages 107: Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis
Melanoma, one of the aggressive cancers, is known to be resistant to chemotherapy. Because of its aggressive nature, effectively inducing apoptosis is necessary to treat melanoma. Erythroid differentiation regulator 1 (Erdr1) is known to be a stress-related survival factor exhibiting anti-cancer effects in several cancers. However, little is known about the functions and underlying mechanisms of Erdr1 so far. To demonstrate the effect of Erdr1 in melanoma apoptosis, recombinant murine Erdr1 was injected into mice implanted with B16F10 melanoma cells. In vivo tumor growth was signi... περισσότερα »
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years: Purpose: To review the published literature on management strategies for lacrimal gland carcinomas. Methods: Review of relevant articles in PubMed published in English from the year of 1970 through September 2014. Results: A review of literature suggests that treatment strategies for… Continue reading Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years
Reprogramming for Cardiac Regeneration – Strategies for Innovation
Abstract It is well-known that the human myocardium has a low capacity for self-regeneration. This fact is especially important after acute myocardial infarction with subsequent heart failure and adverse tissue remodeling. New potential strategies have recently emerged for treating heart diseases, such as the possibility of generating large quantities of cardiomyocytes through genetic iPSC reprogramming,… Continue reading Reprogramming for Cardiac Regeneration – Strategies for Innovation
Nasolacrimal System Aeration on Computed Tomographic Imaging: Sex and Age Variation
Nasolacrimal System Aeration on Computed Tomographic Imaging: Sex and Age Variation: Purpose: To investigate variation in aeration of the nasolacrimal drainage system between age groups and genders, and to report the reliability of repeated aeration grading and nasolacrimal canal measurements on CT. Methods: Retrospective review of CT images from 92 individuals, 60 female and 32… Continue reading Nasolacrimal System Aeration on Computed Tomographic Imaging: Sex and Age Variation
This has been a sad week for cancer news, but thoughts like these are the some of the best tributes imaginable. https://t.co/0aPcw2hf7g
This has been a sad week for cancer news, but thoughts like these are the some of the best tributes imaginable. https://t.co/0aPcw2hf7g from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/687619920683745281 via IFTTT
“Tag-Team” Orbital and Strabismus Surgeries with Immediate Reconstruction After Tumor Excision Metastatic to the Inferior Rectus
“Tag-Team” Orbital and Strabismus Surgeries with Immediate Reconstruction After Tumor Excision Metastatic to the Inferior Rectus: Carcinoid tumors are rare, slow-growing, low-grade neuroendocrine tumors with a propensity for orbital metastatic spread. The typical treatment paradigm for localized orbital disease involves excision, adjuvant radiotherapy, and/or receptor-targeted chemotherapy, followed by delayed evaluation for reconstructive strabismus surgery. We… Continue reading “Tag-Team” Orbital and Strabismus Surgeries with Immediate Reconstruction After Tumor Excision Metastati... περισσότερα »
RT @kingsmedicine : Today 12-2pm #AskNutrition takeover of @KingsCollegeLon – talk to the nutrition experts! https://t.co/8Xo76EGowz
RT @kingsmedicine : Today 12-2pm #AskNutrition takeover of @KingsCollegeLon – talk to the nutrition experts! https://t.co/8Xo76EGowz from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/687616517266096128 via IFTTT
Resurfacing (CO2; Er:YAG) versus fractional (nonablative fractional laser NAFL; ablative fractional laser AFL) lasers : Acne scars may best be treated with the Er:YAG laser and AFL
Comparison of 4 Different Lasers for Acne Scars: Resurfacing and Fractional Lasers via British Association of Plastic Surgeons Publication date: Available online 7 January 2016 Source:Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Hi-Jin You, Deok-Woo Kim, Eul-Sik Yoon, Seung-Ha Park BackgroundAcne scars are common and cause cosmetic problems. There is a multitude of treatment… Continue reading Resurfacing (CO2; Er:YAG) versus fractional (nonablative fractional laser NAFL; ablative fractional laser AFL) lasers : Acne scars may best be treated with the Er:YAG laser... περισσότερα »
Nivolumab in melanoma: Data subsequently submitted improve assessment result https://t.co/Qo1DpIP7sE
Nivolumab in melanoma: Data subsequently submitted improve assessment result https://t.co/Qo1DpIP7sE from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/687616437121355776 via IFTTT
Parents of terror victims. A longitudinal study of parental mental health following the 2011 terrorist attack on Utøya Island
Publication date: Available online 13 January 2016 Source:Journal of Anxiety Disorders Author(s): Siri Thoresen, Tine K. Jensen, Tore Wentzel-Larsen, Grete Dyb Background and aimsLittle is known about parents’ health following their children’s exposure to trauma. We investigated the mental health of parents of young terrorist survivors and assessed parental distress and guilt as potential predictors… Continue reading Parents of terror victims. A longitudinal study of parental mental health following the 2011 terrorist attack on Utøya Island
RT @altmetric : Check out our new explainer video! Getting started with @altmetric badges https://t.co/tieEc6PSwU #altmetrics
RT @altmetric : Check out our new explainer video! Getting started with @altmetric badges https://t.co/tieEc6PSwU #altmetrics from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://twitter.com/ecancer/status/687615182458220544 via IFTTT
Reprogramming for Cardiac Regeneration – Strategies for Innovation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Abstract It is well-known that the human myocardium has a low capacity for self-regeneration. This fact is especially important after acute myocardial infarction with subsequent heart failure and adverse tissue remodeling. New potential strategies have recently emerged for treating heart diseases, such as the possibility of generating large quantities of cardiomyocytes through genetic iPSC reprogramming, […]
Motivation Classification and Grade Prediction for MOOCs Learners
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
While MOOCs offer educational data on a new scale, many educators find great potential of the big data including detailed activity records of every learner. A learner’s behavior such as if a learner will drop out from the course can be predicted. How to provide an effective, economical, and scalable method to detect cheating on […]
Retreatment Predictions in Odontology by means of CBR Systems
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
The field of odontology requires an appropriate adjustment of treatments according to the circumstances of each patient. A follow-up treatment for a patient experiencing problems from a previous procedure such as endodontic therapy, for example, may not necessarily preclude the possibility of extraction. It is therefore necessary to investigate new solutions aimed at analyzing data […]
Eyes Open on Sleep and Wake: In Vivo to In Silico Neural Networks
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Functional and effective connectivity of cortical areas are essential for normal brain function under different behavioral states. Appropriate cortical activity during sleep and wakefulness is ensured by the balanced activity of excitatory and inhibitory circuits. Ultimately, fast, millisecond cortical rhythmic oscillations shape cortical function in time and space. On a much longer time scale, brain […]
Functional Integration between Salience and Central Executive Networks: A Role for Action Video Game Experience
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Action video games (AVGs) have attracted increasing research attention as they offer a unique perspective into the relation between active learning and neural plasticity. However, little research has examined the relation between AVG experience and the plasticity of neural network mechanisms. It has been proposed that AVG experience is related to the integration between Salience […]
Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Although the literature reports a higher incidence of anxiety disorders in women, the majority of basic research has focused on male rodents, thus resulting in a lack of knowledge on the neurobiology of anxiety in females. Bridging this gap is crucial for the design of effective translational interventions in women. One of the key brain […]
An Effective Color Quantization Method Using Octree-Based Self-Organizing Maps
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
Color quantization is an essential technique in color image processing, which has been continuously researched. It is often used, in particular, as preprocessing for many applications. Self-Organizing Map (SOM) color quantization is one of the most effective methods. However, it is inefficient for obtaining accurate results when it performs quantization with too few colors. In […]
The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain. The absence or presence of PNN strongly correlates with neuronal plasticity. It is not clear how PNN regulate plasticity. The repulsive axon guidance proteins Semaphorin (Sema) 3A and Sema3B […]
Caffeine-Induced Suppression of GABAergic Inhibition and Calcium-Independent Metaplasticity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
GABAergic inhibition plays a critical role in the regulation of neuron excitability; thus, it is subject to modulations by many factors. Recent evidence suggests the elevation of intracellular calcium () and calcium-dependent signaling molecules underlie the modulations. Caffeine induces a release of calcium from intracellular stores. We tested whether caffeine modulated GABAergic transmission by increasing […]
This has been a sad week for cancer news, but thoughts like these are the some of the best tributes imaginable. https://t.co/0aPcw2hf7g
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 19 δευτερόλεπτα
This has been a sad week for cancer news, but thoughts like these are the some of the best tributes imaginable. https://t.co/0aPcw2hf7g from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/687619920683745281 via IFTTT
Bone graft substitutes and bone morphogenetic proteins for osteoporotic fractures: what is the evidence?
Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Kf6qQO via IFTTT
Intramuscular diaphragmatic stimulation for patients with traumatic high cervical injuries and ventilator dependent respiratory failure: a systematic review of safety and effectiveness
Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Q7CeNS via IFTTT
Main differences in osteoporotic fracture models: which should I use?
Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1Q7Cexb via IFTTT
Pre-hospital Glasgow Coma Score predicts emergent intervention following helicopter transfer for spontaneous subarachnoid hemorrhage
World Neurosurgery from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1URf5ON via IFTTT
Assessment of common preoxygenation strategies outside of the operating room environment
Academic Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1URf2Tp via IFTTT
Achieving ventricular rate control using metoprolol in beta-blocker naïve patients versus patients on chronic beta-blocker therapy
The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RGnabL via IFTTT
Asymmetry of the odontoid lateral mass interval in pediatric trauma CT: do we need to investigate further
American Journal of Neuroradiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1URf2CP via IFTTT
The epidemiology and outcomes of women with postpartum haemorrhage requiring massive transfusion with eight or more units of red cells: A national cross-sectional study
BJOG: An International Journal of Obstetrics and Gynaecology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RGn7fY via IFTTT
The iTClamp in the management of prehospital haemorrhage
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Multicenter Evaluation of a 0-Hour/1-Hour Algorithm in the Diagnosis of Myocardial Infarction With High-Sensitivity Cardiac Troponin T
Annals of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RGn9EI via IFTTT
Skin glue reduces the failure rate of emergency department–inserted peripheral intravenous catheters: a randomized controlled trial
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Evaluation of emergency pediatric tracheal intubation by pediatric anesthesiologists on inpatient units and the emergency department
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Longer time to antibiotics and higher mortality among septic patients with non-specific presentations -a cross sectional study of Emergency Department patients indicating that a screening tool may improve identification
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RGn6sy via IFTTT
Effects of long axis in-plane versus short axis out-of-plane techniques during ultrasound-guided vascular access: Preliminary evidence
The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1RGn6c0 via IFTTT
CXCL5 signaling is a shared pathway of neuroinflammation and blood–brain barrier injury contributing to white matter injury in the immature brain
Journal of Neuroinflammation from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1URf0L8 via IFTTT
Accuracy of bedside ultrasonography for the diagnosis of finger fractures
The American Journal of Emergency Medicine from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1UReY63 via IFTTT
Interobserver reliability of the Schatzker and Luo classification systems for tibial plateau fractures
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Higher serum level of myoglobin could predict the more severity and poor outcome for patients with sepsis
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A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 49 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, […]
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Publication date: Available online 14 January 2016 Source:Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, […]
The Function of Naringin in Inducing Secretion of Osteoprotegerin and Inhibiting Formation of Osteoclasts
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Osteoporosis has become one of the most prevalent and costly diseases in the world. It is a metabolic disease characterized by reduction in bone mass due to an imbalance between bone formation and resorption. Osteoporosis causes fractures, prolongs bone healing, and impedes osseointegration of dental implants. Its pathological features include osteopenia, degradation of bone tissue […]
IJMS, Vol. 17, Pages 90: Function and Regulation of Heterotrimeric G Proteins during Chemotaxis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Chemotaxis, or directional movement towards an extracellular gradient of chemicals, is necessary for processes as diverse as finding nutrients, the immune response, metastasis and wound healing. Activation of G-protein coupled receptors (GPCRs) is at the very base of the chemotactic signaling pathway. Chemotaxis starts with binding of the chemoattractant to GPCRs at the cell-surface, which […]
IJMS, Vol. 17, Pages 105: Urine Aquaporin-2: A Promising Marker of Response to the Arginine Vasopressin Type-2 Antagonist, Tolvaptan in Patients with Congestive Heart Failure
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the concentrating and diluting ability of the kidney. The arginine vasopressin type-2 antagonist, tolvaptan, is a new-generation diuretic; it is especially indicated in patients with decompensated heart failure refractory to conventional […]
IJMS, Vol. 17, Pages 102: Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 50 δευτερόλεπτα
During the last few decades, improvements in the planning and application of radiotherapy in combination with surgery and chemotherapy resulted in increased survival rates of tumor patients. However, the success of radiotherapy is impaired by two reasons: firstly, the radioresistance of tumor cells and, secondly, the radiation-induced damage of normal tissue cells located in the […]
Langerhans Cell Histiocytosis of the Orbit: Spectrum of Disease and Risk of Central Nervous System Sequelae in Unifocal Cases
Langerhans Cell Histiocytosis of the Orbit: Spectrum of Disease and Risk of Central Nervous System Sequelae in Unifocal Cases: [image: image]Purpose: To describe the spectrum of disease extent and clinical response in Langerhans cell histiocytosis (LCH) presenting with orbital involvement and to determine if unifocal orbital disease increases the risk for central nervous system sequelae (CNS-LCH). Methods: Retrospective chart review of patients with orbital LCH representing a range of severity treated at the Children’s Hospital of Wisconsin from 2003 to 2011; analysis of current inte... περισσότερα »
Blepharospasm Treatment Patterns
A Survey of Current Blepharospasm Treatment Patterns Among Oculoplastic Surgeons: [image: image] Purpose: To determine the current practice pattern of ASOPRS members injecting onabotulinumtoxinA for Blepharospasm. Methods: An invitation to participate in a web-based, anonymous survey was sent to current members of American Society of Ophthalmic Plastic and Reconstructive Surgeons (ASOPRS) via e-mail. The survey consisted of 9 questions and used the Research Electronic Data Capture online application. Institutional Review board approval was obtained for this study. Results: Forty-one... περισσότερα »
Pleomorphic Adenoma With Prominent Clear Cell Myoepithelioma Component of the Lacrimal Gland
Pleomorphic Adenoma With Prominent Clear Cell Myoepithelioma Component of the Lacrimal Gland: [image: image] A case of a pleomorphic adenoma of the lacrimal gland with a prominent clear cell myoepitheliomatous component was reported. An 81-year-old Caucasian woman experienced a 2-month history of right supraorbital swelling and proptosis. Excisional biopsy revealed a multicomponent lesion including a stromal component featuring glandular structures made of small epithelioid and spindle cells and a trabecular component with small islands of vacuolated cells, displaced nuclei, and cl...περισσότερα »
Scanning Electron Microscopic Features of Nasolacrimal Silastic Stents Retained for Prolong Durations Following Dacryocystorhinostomy
Scanning Electron Microscopic Features of Nasolacrimal Silastic Stents Retained for Prolong Durations Following Dacryocystorhinostomy: [image: image]Purpose: The aims of this study were to examine the scanning electron microscopic features of silastic nasolacrimal duct stents retained for long durations following a dacryocystorhinostomy. Methods: A prospective interventional study was performed on stents retrieved from patients who were lost to follow up after a dacryocystorhinostomy with Crawford stent insertion. Long duration was defined as stents retrieved at a minimum of 1 year f... περισσότερα »
Histopathology and Immunophenotyping of Congenital Lacrimal (Anlage) Fistulae
Histopathology and Immunophenotyping of Congenital Lacrimal (Anlage) Fistulae: [image: image]Purpose: To report the histopathological and immuno histochemical features of congenital lacrimal fistulae. Methods: Retrospective chart review of all patients who underwent a fistulectomy for congenital lacrimal fistulae, over a 3-year period from a single surgeon’s (M.J.A.) database, were included in the study. A detailed lacrimal system evaluation was performed, and intraoperative findings were documented. The excised fistulae were studied using hematoxylin and eosin and periodic acid-Schi...περισσότερα »
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years: [image: image]Purpose: To review the published literature on management strategies for lacrimal gland carcinomas. Methods: Review of relevant articles in PubMed published in English from the year of 1970 through September 2014. Results: A review of literature suggests that treatment strategies for adenoid cystic carcinoma of lacrimal gland are varied, but local control does not necessarily prevent future delayed distant relapse. Tumor size and histologic features of lacrimal gland carcinoma seem ... περισσότερα »
Nasolacrimal System Aeration on Computed Tomographic Imaging: Sex and Age Variation
Nasolacrimal System Aeration on Computed Tomographic Imaging: Sex and Age Variation: [image: image]Purpose: To investigate variation in aeration of the nasolacrimal drainage system between age groups and genders, and to report the reliability of repeated aeration grading and nasolacrimal canal measurements on CT. Methods: Retrospective review of CT images from 92 individuals, 60 female and 32 male, was conducted by 3 independent reviewers for the presence of air within the nasolacrimal drainage system. Diameter and area measurements were also obtained at the smallest identifiable por...περισσότερα »
“Tag-Team” Orbital and Strabismus Surgeries with Immediate Reconstruction After Tumor Excision Metastatic to the Inferior Rectus
“Tag-Team” Orbital and Strabismus Surgeries with Immediate Reconstruction After Tumor Excision Metastatic to the Inferior Rectus: [image: image]Carcinoid tumors are rare, slow-growing, low-grade neuroendocrine tumors with a propensity for orbital metastatic spread. The typical treatment paradigm for localized orbital disease involves excision, adjuvant radiotherapy, and/or receptor-targeted chemotherapy, followed by delayed evaluation for reconstructive strabismus surgery. We present a 58-year-old female patient with carcinoid tumor metastatic to the right inferior rectus muscle who ...περισσότερα »
Resurfacing (CO2; Er:YAG) versus fractional (nonablative fractional laser [NAFL]; ablative fractional laser [AFL]) lasers : Acne scars may best be treated with the Er:YAG laser and AFL
Comparison of 4 Different Lasers for Acne Scars: Resurfacing and Fractional Lasers via British Association of Plastic Surgeons Publication date: Available online 7 January 2016 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Hi-Jin You, Deok-Woo Kim, Eul-Sik Yoon, Seung-Ha Park BackgroundAcne scars are common and cause cosmetic problems. There is a multitude of treatment options for acne scars, including dermabrasion, chemical peeling, and fillers, but the advent of laser technology has greatly improved treatment of acne scars. Although there are several laser... περισσότερα »
Adipose Tissue-Effect of Mechanical Force on Fat Tissue Engineering
Mechanobiology and Mechanotherapy of Adipose Tissue-Effect of Mechanical Force on Fat Tissue Engineering: Summary: Our bodies are subjected to various mechanical forces, which in turn affect both the structure and function of our bodies. In particular, these mechanical forces play an important role in tissue growth and regeneration. Adipocytes and adipose-derived stem cells are both mechanosensitive and mechanoresponsive. The aim of this review is to summarize the relationship between mechanobiology and adipogenesis. PubMed was used to search for articles using the following keyword... περισσότερα »
Infection in the Nasal Tip Caused by Acellular Dermal Matrix
Infection in the Nasal Tip Caused by Acellular Dermal Matrix: [image: image]Summary: A 19-year-old female patient visited our clinic for rhinoplasty. She complained about her low take-off point, which was apparent in profile view, and wanted slight tip projection. She refused additional cartilage harvesting from ears or ribs but consented to the use of homologous tissue, including acellular dermal matrix, for her dorsum and tip. Septoturbinoplasty was performed, and only a very small amount of septal cartilage could be harvested. It was used as both the columellar strut and the alar... περισσότερα »
Hyperspectral Imaging for Burn Depth Assessment
Hyperspectral Imaging for Burn Depth Assessment in an Animal Model: [image: image]Background: Differentiating between superficial and deep-dermal (DD) burns remains challenging. Superficial-dermal burns heal with conservative treatment; DD burns often require excision and skin grafting. Decision of surgical treatment is often delayed until burn depth is definitively identified. This study’s aim is to assess the ability of hyperspectral imaging (HSI) to differentiate burn depth. Methods: Thermal injury of graded severity was generated on the dorsum of hairless mice with a heated brass... περισσότερα »
The Role of Embryologic Fusion Planes in the Invasiveness and Recurrence of Basal Cell Carcinoma: A Classic Mix-Up of Causation and Correlation
The Role of Embryologic Fusion Planes in the Invasiveness and Recurrence of Basal Cell Carcinoma: A Classic Mix-Up of Causation and Correlation: [image: image]Background: The facial embryologic fusion planes as regions of mesenchymal and ectodermal fusion of the primordial facial processes during embryological development have been suggested to influence the spread, invasiveness, pathogenesis, and recurrence of cutaneous carcinoma. This study sought to establish whether basal cell carcinoma (BCC) originating in embryologic fusion planes has a greater propensity for earlier depth of ...περισσότερα »
Chronic Sclerosing Osteomyelitis of the Mandible Treated with Hemimandibulectomy and Fibular Free Flap Reconstruction
Chronic Sclerosing Osteomyelitis of the Mandible Treated with Hemimandibulectomy and Fibular Free Flap Reconstruction: [image: image]Summary: Primary chronic osteomyelitis of the mandible is a rare condition that presents with a long-standing chronic facial swelling over the mandible, pain with mastication, and trismus. With no clinically appreciated acute phase, the aetiology often remains unknown. Many patients achieve adequate symptom control with broad-spectrum antibiotics, hyperbaric oxygen therapy and surgical debridement, or decortication of bone sequestration. However, becau...περισσότερα »
A Multisite Study of Oral Clefts and Associated Abnormalities
A Multisite Study of Oral Clefts and Associated Abnormalities in Thailand: The Epidemiologic Data: [image: image] Background: This study aimed to obtain epidemiological data of birth incidences of cleft lips and/or cleft palates (CLP) in the Thai population with associated risk factors. Methods: The data were collected for a period of 12 months between 2003 and 2004 for infants’ deliveries with CLP and associated risk factors in all hospitals of 6 provinces from 4 regions of Thailand. The birth incidence, related factors with cleft birth, and linkage with geographical area were ana... περισσότερα »
A Natural Design in Female Hairline Correction Surgery
Novel Principles and Techniques to Create a Natural Design in Female Hairline Correction Surgery: [image: image]Background: Female hairline correction surgery is becoming increasingly popular. However, no guidelines or methods of female hairline design have been introduced to date. Methods: The purpose of this study was to create an initial framework based on the novel principles of female hairline design and then use artistic ability and experience to fine tune this framework. An understanding of the concept of 5 areas (frontal area, frontotemporal recess area, temporal peak, infrat...περισσότερα »
A Subglandular Breast Cerebrospinal Fluid Pseudocyst Following Postsurgical Shunt Migration
A Subglandular Breast Cerebrospinal Fluid Pseudocyst Following Postsurgical Shunt Migration: [image: image]Summary: Cerebrospinal fluid (CSF) drainage catheters have been associated with numerous complications in various anatomic locations, because of migration, infection, and obstruction. However, breast-related CSF shunt complications tend to occur infrequently or have seldom been reported in the empirical literature. Therefore, a case is presented detailing a breast pseudocyst caused by migration and subsequent coiling of a ventriculoperitoneal shunt in the right breast pocket. T...περισσότερα »
Superior sulcus filler injection is a nonsurgical method to rejuvenate the upper face
“Walk the Rim, Feel the Bone” Technique in Superior Sulcus Filling: [image: image]Summary: Superior sulcus filler injection is a nonsurgical method to rejuvenate the upper face. Blindness and stroke are devastating complications of facial filler injection. This study describes an injection technique that minimizes the risk of blindness and includes a case study demonstrating the cosmetic benefits of this procedure. To avoid retrograde injection of filler embolus into the ophthalmic artery, we advocate a “‘walk the rim, feel the bone” approach. Small boluses of hyaluronic acid filler... περισσότερα »
Collagen Structural Alterations Contribute to Stiffening of Tissue After Split-Thickness Skin Grafting
Collagen Structural Alterations Contribute to Stiffening of Tissue After Split-Thickness Skin Grafting: [image: cover.gif?v=1&s=4e06cdb9cbac42b01d5dfc71] Abstract The gold standard treatment for full thickness injuries of the skin is autologous split-thickness skin grafting. This involves harvesting the epidermis and superficial dermis from healthy skin and transplanting it onto the prepared wound bed. The donor site regenerates spontaneously, but the appendages and cellular components from the dermal layer are excluded from the graft. As a result, the new tissue is inferior; th... περισσότερα »
Microsensor and transcriptomic signatures of oxygen depletion in biofilms associated with chronic wounds
Microsensor and transcriptomic signatures of oxygen depletion in biofilms associated with chronic wounds: [image: cover.gif?v=1&s=4e06cdb9cbac42b01d5dfc71] Abstract Biofilms have been implicated in delayed wound healing, although the mechanisms by which biofilms impair wound healing are poorly understood. Many species of bacteria produce exotoxins and exoenzymes that may inhibit healing. In addition, oxygen consumption by biofilms and by the responding leukocytes, may impede wound healing by depleting the oxygen that is required for healing. In this study, we used oxygen microse... περισσότερα »
Lymphatic Vessel Grafting for Prevention of Venous Reflux into a Sclerotic Lymphatic Vessel in Supermicrosurgical Lymphaticovenular Anastomosis
Lymphatic Vessel Grafting for Prevention of Venous Reflux into a Sclerotic Lymphatic Vessel in Supermicrosurgical Lymphaticovenular Anastomosis: Treatment for progressive lymphedema refractory to conservative therapies is challenging. Several surgical treatments have been reported to be useful to improve the disease’s conditions, and lymphatic supermicrosurgery or supermicrosurgical lymphaticovenular anastomosis (LVA) is the least invasive one among them.1,2 In LVA, a lymphatic vessel is anastomosed to a vein an intima-to-intima coaptation manner to prevent post-anastomotic thrombos... περισσότερα »
The Short Mood and Feelings Questionnaire (SMFQ) for screening children and adolescents seeking plastic surgery
Brazilian Portuguese version of the Short Mood and Feelings Questionnaire (SMFQ) for screening children and adolescents seeking plastic surgery: The development of patient-reported outcome (PRO) measures to assess emotional state in children and adolescents seeking plastic surgery is important to determine whether the intervention is indicated or not. According to the American Society of Plastic Surgeons, nearly 236,000 cosmetic plastic surgeries were performed in adolescents aged between 13 and 19 in 2012.1 In Brazil, there was an increase of 141% in the number of plastic surgeries ... περισσότερα »
Using Frozen Section Margin Control Technique to Manage Non-melanomatous Skin Lesions in High Risk Sites
Using Frozen Section Margin Control Technique to Manage Non-melanomatous Skin Lesions in High Risk Sites: In the UK, non-melanoma skin cancers (NMSC) that are incompletely excised, recurrent or in sites high risk for incomplete excision are often offered Mohs micrographic surgery (MMS). Waiting times and geographical access for MMS are variable, impacting upon patient preference for other treatments. Our unit offers excision of such lesions under complete margin frozen section histological examination.
Timing Pediatric Ear Reconstruction: The Case for a Range of Options
Timing Pediatric Ear Reconstruction: The Case for a Range of Options: We would like to address the concerns about early ear reconstruction raised by Bulstrude et al.1 The authors state they agree there is significant psychological benefit to auricular reconstruction, but do not support the suggestion that undergoing surgery earlier than nine years of age may be a protective factor for children with microtia.2
Obstetrical Brachial Plexus Palsy: Can Excision of Upper Trunk Neuroma and Nerve Grafting Improve Function in Babies with Adequate Elbow Flexion at Nine Months of Age?
Obstetrical Brachial Plexus Palsy: Can Excision of Upper Trunk Neuroma and Nerve Grafting Improve Function in Babies with Adequate Elbow Flexion at Nine Months of Age?: Accepted indications for exploration in obstetrical brachial plexus palsy (OBPP) vary by center. Most agree that full elbow flexion against gravity at nine months of age implies high chance of spontaneous recovery and thus excludes a baby from surgical intervention. However, there are certain movements of the shoulder and forearm that may not be used frequently by the infant, but are extremely important functionally ... περισσότερα »
Basal cell carcinomata-risk factors for incomplete excision and results of re-excision
Basal cell carcinomata-risk factors for incomplete excision and results of re-excision: Re-excising incompletely excised basal cell carcinomas can be unsatisfactory when there is no residual tumour present. Recommended guidelines do suggest re-excision as a treatment modality however its value has been questioned due to low or variable residual tumour presence. We analysed our incomplete excisions and re-excision rates, and residual tumour presence over an 18-month period in a single unit.
PLGA based drug delivery systems – promising carriers for wound healing activity
PLGA based drug delivery systems – promising carriers for wound healing activity: Abstract Wound treatment remains one of the most prevalent and economically burdensome healthcare issues in the world. Current treatment options are limited and require repeated administrations which led to the development of new therapeutics to satisfy the unmet clinical needs. Many potent wound healing agents were discovered but most of them are fragile and/or sensitive to *in vivo* conditions. Poly (Lactic-co-Glycolic Acid) (PLGA) is a widely used biodegradable polymer approved by FDA and EMA as an... περισσότερα »
To recreate an acute cervicomandibular angle
Hyo neck lift: Preliminary report via Plastique Esthétique Publication date: Available online 11 January 2016 *Source:*Annales de Chirurgie Plastique Esthétique Author(s): C. Le Louarn BackgroundThe aim of neck lift is to recreate an acute cervicomandibular angle. Surgical neck rejuvenation typically is associated with posterosuperior traction on the platysma (PLA) with an anterior vertical PLA corset or a digastric corset. Medium-term instability can exist with these procedures.ObjectivesA novel platysmaplasty technique called the hyo neck lift is described and its surgical efficacy i...περισσότερα »
Semipermanent Volumization by an Absorbable Filler: Onlay Injection Technique to the Bone
Semipermanent Volumization by an Absorbable Filler: Onlay Injection Technique to the Bone: [image: image] Background: Hyaluronic acid (HA) fillers have become the most popular tool for wrinkle treatment and volumization, although HA is generally absorbed within 6–12 months and requires repeated treatments to maintain the effects. Methods: HA was injected onto the bone for volumization with a small 30-gauge needle to examine the long-lasting effects. Of the 63 Japanese patients with 97 treated sites followed up more than 12 months, 51 had HA injections for cosmetic purposes and 12 we...περισσότερα »
Bioprosthetic Tissue Matrices in Complex Reconstructions
Bioprosthetic Tissue Matrices in Complex Abdominal Wall Reconstruction: [image: image]Background: Complex abdominal defects are difficult problems encountered by surgeons in multiple specialties. Although current evidence supports the primary repair of these defects with mesh reinforcement, it is unclear which mesh is superior for any given clinical scenario. The purpose of this review was to explore the characteristics of and clinical relevance behind bioprosthetic tissue matrices in an effort to better clarify their role in abdominal wall reconstruction. Methods: We reviewed the pe... περισσότερα »
Management of Vascular Malformations
Management of Vascular Malformations: [image: image]Background: Even though vascular malformations are well categorized, further details are relatively unknown. Of treated patients regarding the frequency, demographic distributions, and other related factors by multivariate regression analyses in proportion to total vascular malformations, methods of treatment and how to manage them have not been elucidated thoroughly. Methods: From January 2006 to March 2012, consecutively treated patients with vascular anomalies were included in this investigation at least 1-year follow-up. Results...περισσότερα »
Mandibular Metastases of Papillary Thyroid Carcinoma Treated by Hemimandibulectomy and Costochondral Rib Graft
Mandibular Metastases of Papillary Thyroid Carcinoma Treated by Hemimandibulectomy and Costochondral Rib Graft: [image: image]Summary: Papillary thyroid carcinoma (PTC) is the most common and well-differentiated cancer of the thyroid. Unlike most cancers, spread to local lymph node does not worsen the survival rate of PTC, and complete resection of the metastases seems to be important and may have favorable effects on the prognosis. A 33-year-old woman was referred to our clinic with a mass involving the right angulus mandible. Incisional biopsy of the mass diagnosed follicular vari... περισσότερα »
Effects of Erythropoietin on Adipose Tissue: A Possible Strategy in Refilling
Effects of Erythropoietin on Adipose Tissue: A Possible Strategy in Refilling: [image: image]Background: The increased resorption and the difficulty of the fat graft take following autologous fat transplantation procedure are associated with reduced fat tissue revascularization and increased apoptosis of adipose cells. We suppose that the lipofilling procedure induces an inflammatory environment within the fat graft mass, whose evolution influences the efficacy of autologous fat graft survival. Erythropoietin (EPO) is a glycoprotein hormone known to exert angiogenetic and anti-infla... περισσότερα »
Surgical Treatment of Facial Infantile Hemangiomas: An Analysis Based on Tumor Characteristics and Outcomes.
Surgical Treatment of Facial Infantile Hemangiomas: An Analysis Based on Tumor Characteristics and Outcomes.: Background. Surgical treatment of infantile hemangiomas may definitively interfere in patient appearance. The use of an algorithm is essential to select best candidates. The objective of this study is to evaluate outcomes of surgical treatment based on tumor characteristics. Methods. Following an algorithm, 74 patients were surgically treated between 1997 and 2010. Demographic data, tumor characteristics, surgical approach and outcomes were evaluated. Results. Female to male ... περισσότερα »
Lengthening Temporalis Myoplasty for Single-Stage Smile Reconstruction in Children with Facial Paralysis.
Lengthening Temporalis Myoplasty for Single-Stage Smile Reconstruction in Children with Facial Paralysis.: No abstract available
Adipose stem cells isolated from excised burned tissue: is there potential for clinical use?.
Adipose stem cells isolated from excised burned tissue: is there potential for clinical use?.: Recent studies have shown the benefits of autologous fat grafting and adipose-derived regenerative cells in the treatment of burn wounds and scars. In patients presenting extensive burns, these therapies could be useful in the acute and chronic phases of wound healing. However, performing liposuction to harvest fat and isolate cells from these often critically ill patients is not an option. Some researchers collected burn surgical discards and isolated cells that showed multi-lineage diffe... περισσότερα »
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
Publication date: Available online 14 January 2016 *Source:*Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, nor for effects of electrical stimulation, such as spectral smearing as a function of stimulus intensity. In this paper, a neural model that accounts for stochastic firing, pa...περισσότερα »
Deszendierende nekrotisierende Mediastinitis
Deszendierende nekrotisierende Mediastinitis: Zusammenfassung HintergrundDie deszendierende nekrotisierende Mediastinitis (DNM) stellt einen interdisziplinären Notfall dar, bei dem ein odontogener oder oropharyngealer Infektfokus entlang präformierter zervikothorakaler Spatien auf das Mediastinum übergreift. Material und MethodenBei sieben Patienten wurde die Diagnose der DNM anhand pathognomonischer radiologischer Befunde in der Computertomographie gestellt und ein standardisiertes transzervikales und offenes transthorakales radikales Débridement durchgeführt. ErgebnisseIm...περισσότερα »
Hemifacial microsomia and Non-syndromic cleft lip/palate
Cleft characteristics and treatment outcomes in hemifacial microsomia compared to non-syndromic cleft lip/palate via Oral and Maxillofacial Surgery [image: alertIcon.gif] Publication date: Available online 6 January 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): K.M. Dentino, A. Valstar, B.L. Padwa The goal of this study was to describe the clinical characteristics and treatment outcomes of patients with hemifacial microsomia (HFM) and cleft lip/palate (CL/P), and to compare them to a historic cohort of patients with non-syndromic CL/P treated at the sa... περισσότερα »
Effects of platelet-rich plasma in association with bone grafts in maxillary sinus augmentation
Effects of platelet-rich plasma in association with bone grafts in maxillary sinus augmentation: a systematic review and meta-analysis via Oral and Maxillofacial Surgery Publication date: Available online 6 January 2016 *Source:*International Journal of Oral and Maxillofacial Surgery Author(s): C.A.A. Lemos, C.C. Mello, D.M. dos Santos, F.R. Verri, M.C. Goiato, E.P. Pellizzer This systematic review evaluated the effect on bone formation and implant survival of combining platelet-rich plasma (PRP) with bone grafts in maxillary augmentation. A comprehensive review of articles listed in th... περισσότερα »
The versatility of spandex photographic retractor for transoral surgical procedures
The versatility of spandex photographic retractor for transoral surgical procedures via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 7 January 2016 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): David P. Tauro, Uday Kiran Uppada The trend toward transoral access, be it for pathology or facial cosmetic surgery, has become increasingly popular over the last two decades with facial incisions being used more and more sporadically than otherwise. Transoral access because of its inherent limitations, re... περισσότερα »
Fluoride toothpaste supplemented with sodium hexametaphosphate reduces enamel demineralization in vitro
Fluoride toothpaste supplemented with sodium hexametaphosphate reduces enamel demineralization in vitro: Abstract ObjectiveThe aim of this study was to evaluate the effect of fluoride dentifrices combined with sodium hexametaphosphate (HMP) on enamel demineralization in vitro. Material and methodsEnamel bovine blocks were selected by initial surface hardness (SHi) and then divided into five experimental groups (*n* = 12): placebo (without fluoride and without HMP); 1100 ppm F (1100F); and 1100F associated with HMP at 0.5 % (1100HMP0.5%), 1 % (1100HMP1%), and 2 % of HMP (1100HM... περισσότερα »
Clear cell variant of intra-osseous calcifying epithelial odontogenic tumor
: a case report and review of the literature via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 14 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Katarina Rydin, Mats Sjöström, Gunnar Warfvinge We report a rare case of Clear cell calcifying epithelial odontogenic tumor (CCCEOT) and discuss its possibly aggressive behavior. CEOT is a rare benign, but locally aggressive odontogenic tumor and some authors have claimed that the biological behavior of the clear cell variant is even more aggres... περισσότερα »
Primary mucosal melanoma of the oral cavity
: Current therapy and future directions via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 14 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Ioannis Chatzistefanou, Antonia Kolokythas, Konstantonis Vahtsevanos, Konstantinos Antoniades IntroductionPrimary mucosal melanoma of the oral cavity is a highly aggressive malignancy of melanocytic origin. The aim of this study is to report a case series of oral mucosal melanomas and provide a review of the literature in regards to treatment guideli...περισσότερα »
First clinical application of a prompt gamma based in vivo proton range verification system
Publication date: Available online 13 January 2016 *Source:*Radiotherapy and Oncology Author(s): Christian Richter, Guntram Pausch, Steffen Barczyk, Marlen Priegnitz, Isabell Keitz, Julia Thiele, Julien Smeets, Francois Vander Stappen, Luca Bombelli, Carlo Fiorini, Lucian Hotoiu, Irene Perali, Damien Prieels, Wolfgang Enghardt, Michael Baumann Background and purposeTo improve precision of particle therapy, in vivo range verification is highly desirable. Methods based on prompt gamma rays emitted during treatment seem promising but have not yet been applied clinically. Here we report...περισσότερα »
Weight loss is associated with increased NAD(+)/SIRT1 expression but reduced PARP activity in white adipose tissue.
*Weight loss is associated with increased NAD(+)/SIRT1 expression but reduced PARP activity in white adipose tissue.* J Clin Endocrinol Metab. 2016 Jan 13;:jc20153054 Authors: Rappou E, Jukarainen S, Rinnankoski-Tuikka R, Kaye S, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Saunavaara V, Rissanen A, Virtanen KA, Pirinen E, Pietiläinen KH Abstract CONTEXT: Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) are two important NAD(+)-dependent enzyme families with opposing metabolic effects. Energy shortage increases NAD(+) biosynthesis and SIRT activity but reduces PARP ... περισσότερα »
Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.
*Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.* J Clin Endocrinol Metab. 2016 Jan 13;:jc20151710 Authors: Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, Torpy DJ Abstract OBJECTIVE: This clinical practice guideline addresses the diagnosis and treatment of primary adrenal insufficiency. PARTICIPANTS: The Task Force included a chair, selected by The Clinical Guidelines Subcommittee of the Endocrine Society, eight additional clinicians experienced with ... περισσότερα »
Gout.
*Gout.* Isr Med Assoc J. 2015 Nov;17(11):726 Authors: Peleg R, Treister-Goltzman Y PMID: 26757576 [PubMed - in process] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1nkTOCN via IFTTT
Osteoradionecrosis following treatment for Head and Neck Cancer and the effect of radiotherapy dosimetry
: The Guy’s and St Thomas Head and Neck Cancer Unit Experience via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 14 January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Francesca De Felice, Christopher Thomas, Vinod Patel, Steve Connor, Andriana Michaelidou, Chris Sproat, Jerry Kwok, Mary Burke, Damien Reilly, Mark McGurk, Ricard Simo, Andrew Lyons, Richard Oakley, Jean-Pierre Jeannon, Mary Lei, Teresa Guerrero Urbano ObjectivesTo analyse clinical features, dosimetric parameters and outcomes o... περισσότερα »
Does the intravenous administration of frusemide reduce endolymphatic hydrops?
Main ArticleDoes the intravenous administration of frusemide reduce endolymphatic hydrops?F Fiorinoa1 c1, B Mattellinia2, M Ventoa2, L Mazzocchina3, L Bianconia4 and F B Pizzinia5 a1 Department of Otolaryngology, Ospedale Mater Salutis – Azienda Unita Locale Socio Sanitaria 21, Legnago, Italy a2 Department of Otolaryngology, Ospedale di Fidenza, Azienda Unità Sanitaria Parma, Italy a3 Department of Otolaryngology, Ospedale Sacro Cuore, Negrar, Italy a4 Department of Otolaryngology, Ospedale Civile Maggiore – Azienda Ospedaliera Universitaria Integrata Verona, Italy a5 Department of Neu... περισσότερα »
Preservation of cochlear structures and hearing when using the Nucleus Slim Straight (CI422) electrode in children
Main ArticlePreservation of cochlear structures and hearing when using the Nucleus Slim Straight (CI422) electrode in childrenH Skarzynskia1a2 c1, M Matusiaka1a2, A Lorensa1a2, M Furmaneka1a2, A Pilkaa1a2 and P H Skarzynski a1a2a3a4 a1 Institute of Physiology and Pathology of Hearing, Warsaw, Poland a2 World Hearing Centre, Kajetany, Poland a3 Heart Failure and Cardiac Rehabilitation Department, Medical University of Warsaw, Poland a4 Institute of Sensory Organs, Kajetany, Poland Abstract Objective: In cochlear implantation, there are two crucial factors promoting hearing preservation: ... περισσότερα »
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies via Hearing Research Publication date: Available online 14 January 2016 *Source:*Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, nor for effects of electrical stimulation, such as spectral smearing ... περισσότερα »
HMGB1 IS INCREASED BY CFTR LOSS OF FUNCTION, IS LOWERED BY INSULIN AND INCREASES IN VIVO AT ONSET OF CFRD.
*HMGB1 IS INCREASED BY CFTR LOSS OF FUNCTION, IS LOWERED BY INSULIN AND INCREASES IN VIVO AT ONSET OF CFRD.* J Clin Endocrinol Metab. 2016 Jan 13;:jc20153730 Authors: Montanini L, Cirillo F, Smerieri A, Pisi G, Giardino I, d'Apolito M, Spaggiari C, Bernasconi S, Amarri S, Street ME Abstract CONTEXT: Cystic Fibrosis-Related Diabetes (CFRD) is associated with worsening of inflammation and infections, and the beginning of insulin treatment is debated. OBJECTIVES: To verify HMGB1 levels in CF patients according to glucose tolerance state, and analyze relationships with insulin secret... περισσότερα »
JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects.
*JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects.* J Clin Endocrinol Metab. 2016 Jan 13;:jc20153403 Authors: de Filippis T, Marelli F, Nebbia G, Porazzi P, Corbetta S, Fugazzola L, Gastaldi R, Vigone MC, Biffanti R, Frizziero D, Mandarà L, Prontera P, Salerno M, Maghnie M, Tiso N, Radetti G, Weber G, Persani L Abstract CONTEXT: The pathogenesis of congenital hypothyroidism (CH) is still largely unexplained. We previously reported that perturbations of the Notch pathway and knockdown of the ligand jagged1 cause a hyp...περισσότερα »
Weight loss is associated with increased NAD(+)/SIRT1 expression but reduced PARP activity in white adipose tissue.
*Weight loss is associated with increased NAD(+)/SIRT1 expression but reduced PARP activity in white adipose tissue.* J Clin Endocrinol Metab. 2016 Jan 13;:jc20153054 Authors: Rappou E, Jukarainen S, Rinnankoski-Tuikka R, Kaye S, Heinonen S, Hakkarainen A, Lundbom J, Lundbom N, Saunavaara V, Rissanen A, Virtanen KA, Pirinen E, Pietiläinen KH Abstract CONTEXT: Sirtuins (SIRTs) and poly(ADP-ribose) polymerases (PARPs) are two important NAD(+)-dependent enzyme families with opposing metabolic effects. Energy shortage increases NAD(+) biosynthesis and SIRT activity but reduces PARP ... περισσότερα »
Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.
*Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline.* J Clin Endocrinol Metab. 2016 Jan 13;:jc20151710 Authors: Bornstein SR, Allolio B, Arlt W, Barthel A, Don-Wauchope A, Hammer GD, Husebye ES, Merke DP, Murad MH, Stratakis CA, Torpy DJ Abstract OBJECTIVE: This clinical practice guideline addresses the diagnosis and treatment of primary adrenal insufficiency. PARTICIPANTS: The Task Force included a chair, selected by The Clinical Guidelines Subcommittee of the Endocrine Society, eight additional clinicians experienced with ... περισσότερα »
Gene therapy with IL-12 induced enhanced anti-tumor activity in fibrosarcoma mouse model.
*Gene therapy with IL-12 induced enhanced anti-tumor activity in fibrosarcoma mouse model.* Artif Cells Nanomed Biotechnol. 2016 Jan 13;:1-6 Authors: Razi Soofiyani S, Kazemi T, Lotfipour F, Mohammad Hosseini A, Shanehbandi D, Hallaj-Nezhadi S, Baradaran B Abstract Context Immunotherapy is among the most promising modalities for treatment of cancer. Recently, interleukin 12 (IL-12) has been used as an immunotherapeutic agent in cancer gene therapy. IL-12 can activate dendritic cells (DCs) and boost anti-tumor immune responses. Objective In the current study, we have investigated... περισσότερα »
Improving "lab-on-a-chip" techniques using biomedical nanotechnology: a review.
*Improving "lab-on-a-chip" techniques using biomedical nanotechnology: a review.* Artif Cells Nanomed Biotechnol. 2016 Jan 13;:1-6 Authors: Gorjikhah F, Davaran S, Salehi R, Bakhtiari M, Hasanzadeh A, Panahi Y, Emamverdy M, Akbarzadeh A Abstract Nanotechnology and its applications in biomedical sciences principally in molecular nanodiagnostics are known as nanomolecular diagnostics, which provides new options for clinical nanodiagnostic techniques. Molecular nanodiagnostics are a critical role in the development of personalized medicine, which features point-of care performance ...περισσότερα »
Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art.
*Emergence of liposome as targeted magic bullet for inflammatory disorders: current state of the art.* Artif Cells Nanomed Biotechnol. 2016 Jan 13;:1-12 Authors: Rahman M, Kumar V, Beg S, Sharma G, Katare OP, Anwar F Abstract Inflammatory diseases are considered to be highly dreadful ones responsible for higher mortality in the developed countries. This includes cancer, psoriasis, rheumatoid arthritis, and inflammatory bowel disease. The tremendous strides in the area of drug development to find newer molecules like non-steroidal and steroidal agents and immunosuppressant agents ...περισσότερα »
Budesonide-loaded solid lipid nanoparticles for pulmonary delivery: preparation, optimization, and aerodynamic behavior.
*Budesonide-loaded solid lipid nanoparticles for pulmonary delivery: preparation, optimization, and aerodynamic behavior.* Artif Cells Nanomed Biotechnol. 2016 Jan 13;:1-8 Authors: Esmaeili M, Aghajani M, Abbasalipourkabir R, Amani A Abstract Advantages of lipid nanoparticles for pulmonary applications are possibility of deep lung deposition with prolonged release and low toxicity. This study aimed to evaluate the effects of formulation and processing parameters on particle size of prepared SLNs. Budesonide-loaded solid lipid nanoparticles (BUD-SLNs) were prepared with different ... περισσότερα »
Eosinophilic esophagitis: search for noninvasive techniques for long-term monitoring
Eosinophilic esophagitis: search for noninvasive techniques for long-term monitoring: Eosinophilic esophagitis (EoE) is an immune-mediated disease characterized clinically by symptoms of esophageal dysfunction and histologically by a marked eosinophilic infiltrate of the esophageal epithelium in the absence of other causes of esophageal eosinophilia. EoE became increasingly recognized in the pediatric population in the mid-1990s and thereafter in adult patients. Over time, there has been an increase in awareness and possibly prevalence and incidence of EoE.1,2 Currently, the most re... περισσότερα »
AlloDerm Acellular Human Dermis Regenerative Tissue Matrix
Ophthalmic Plastic & Reconstructive Surgery - Current Issue Review of AlloDerm Acellular Human Dermis Regenerative Tissue Matrix in Multiple Types of Oculofacial Plastic and Reconstructive Surgery Bee, Youn-shen; Alonzo, Brock; Ng, John D. · Wednesday, January 13, 2016, 9:32 [image: image]Purpose: AlloDerm acellular human dermis is used for repair or replacement of damaged or inadequate skin tissue. It has been used successfully in multiple types of surgeries, including abdominal wall reconstruction, breast reconstruction, and head and neck reconstruction. Its application to ophthalmi...περισσότερα »
Pediatric Acute Dacryocystitis
Ophthalmic Plastic & Reconstructive Surgery - Current Issue Pediatric Acute Dacryocystitis Ali, Mohammad Javed · Wednesday, January 13, 2016, 9:32 [image: image]Purpose: To review and summarize the symptomatology, microbiology, special clinical entities, management, complications, and outcomes of pediatric acute dacryocystitis. Methods: The author performed a PubMed search of all articles published in English on acute dacryocystitis. Pediatric subpopulations of these articles were reviewed along with the scant literature of direct references to neonatal and pediatric acute dacryocysti...περισσότερα »
Antimicrobial Activity of ILTI, a Kunitz‐Type Trypsin Inhibitor from Inga laurina (SW.) Willd
Abstract Over the last few years, a growing number of proteinase inhibitors have been isolated from plants and particularly from seeds and have shown antimicrobial activity. A 20,000 Da serine peptidase inhibitor, named ILTI, was isolated from Inga laurina seeds and showed potent inhibitory enzymatic activity against trypsin. The aim of this study was to… Continue reading Antimicrobial Activity of ILTI, a Kunitz‐Type Trypsin Inhibitor from Inga laurina (SW.) Willd
The NIJ/IACP Partnership
This video, featuring NIJ Director Nancy Rodriguez and Hassan Aden of the International Association of Chiefs of Police (IACP), describes the partnership between NIJ and IACP and how the two organizations are linking what we know about what works in policing to the field. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Zxdc0H via IFTTT
NIJ’s Law Enforcement Advancing Data and Science (LEADS) Program
This video, featuring NIJ Director Nancy Rodriguez, Hassan Aden of the International Association of Chiefs of Police (IACP), and two scholars from the 2014 Law Enforcement Advancing Data and Science (LEADS) program, describes the LEADS program, how NIJ and IACP are building the next generation of law enforcement leadership, and how the program has benefited… Continue reading NIJ’s Law Enforcement Advancing Data and Science (LEADS) Program
Conviction of Family Annihilator Christopher Vaughn – Recorded Seminar at the NIJ 2015 Impression, Pattern and Trace Evidence Symposium
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Basics of Error Rates in Pattern Evidence – Recorded Seminar at the NIJ 2015 Impression, Pattern and Trace Evidence Symposium
Description not available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Zxd8Ol via IFTTT
Examination of Fibers, Hairs and Personal Lubricants – Recorded Seminar at the NIJ 2015 Impression, Pattern and Trace Evidence Symposium
Description not available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OsQqwi via IFTTT
Conducting a Retroactive Review of Hair Microscopy Cases as a Matter of Shared – Recorded Seminar at the NIJ 2015 Impression, Pattern and Trace Evidence Symposium
Description not available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OsQqfT via IFTTT
What Could Happen When Prosecutors Don’t Follow the Rules – Recorded Seminar at the NIJ 2015 Impression, Pattern and Trace Evidence Symposium
Description not available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1ZxdaWt via IFTTT
Use of Likelihood Ratios for Evidence Quantification in Forensic Applications – Recorded Seminar at the NIJ 2015 Impression, Pattern and Trace Evidence Symposium
Description not available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SPWNiH via IFTTT
Future of Forensics Plenary Session – Plenary Panel at the NIJ 2015 Impression, Pattern and Trace Evidence Symposium
Description not available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1SPWO68 via IFTTT
Superoxide anions produced by Streptococcus pyogenes group A-stimulated keratinocytes are responsible for cellular necrosis and bacterial growth inhibition
Innate Immunity current issue Superoxide anions produced by Streptococcus pyogenes group A-stimulated keratinocytes are responsible for cellular necrosis and bacterial growth inhibition Regnier, E., Grange, P. A., Ollagnier, G., Crickx, E., Elie, L., Chouzenoux, S., Weill, B., Plainvert, C., Poyart, C., Batteux, F., Dupin, N. · Thursday, January 14, 2016, 14:36 Gram-positive *Streptococcus pyogenes* (group A *Streptococcus* or GAS) is a major skin pathogen and interacts with keratinocytes in cutaneous tissues. GAS can cause diverse suppurative and inflammatory infections, such as cel...περισσότερα »
IJMS, Vol. 17, Pages 103: Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical […]
IJMS, Vol. 17, Pages 104: Fourier Transform Mass Spectrometry: The Transformation of Modern Environmental Analyses
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Unknown compounds in environmental samples are difficult to identify using standard mass spectrometric methods. Fourier transform mass spectrometry (FTMS) has revolutionized how environmental analyses are performed. With its unsurpassed mass accuracy, high resolution and sensitivity, researchers now have a tool for difficult and complex environmental analyses. Two features of FTMS are responsible for changing the […]
IJMS, Vol. 17, Pages 100: Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Iron is considered to play a key role in the development and progression of Multiple Sclerosis (MS). In particular, iron that accumulates in myeloid cells after the blood-brain barrier (BBB) seals may contribute to chronic inflammation, oxidative stress and eventually neurodegeneration. Magnetic resonance imaging (MRI) is a well-established tool for the non-invasive study of MS. […]
IJMS, Vol. 17, Pages 107: Erdr1 Suppresses Murine Melanoma Growth via Regulation of Apoptosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Melanoma, one of the aggressive cancers, is known to be resistant to chemotherapy. Because of its aggressive nature, effectively inducing apoptosis is necessary to treat melanoma. Erythroid differentiation regulator 1 (Erdr1) is known to be a stress-related survival factor exhibiting anti-cancer effects in several cancers. However, little is known about the functions and underlying mechanisms […]
Q Fever Manifested as Acalculous Cholecystitis.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Q Fever Manifested as Acalculous Cholecystitis. Isr Med Assoc J. 2015 Nov;17(11):714-6 Authors: Simons M, Heyman SN, Bursztyn M, Shalev O, Hiller N, Israel S PMID: 26757571 [PubMed – in process] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1RGveJC via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OQWfqW via […]
Lymphoma of the Right Atrium and Ventricle.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Lymphoma of the Right Atrium and Ventricle. Isr Med Assoc J. 2015 Nov;17(11):712-3 Authors: Chen S, Atlan K, Gilon D, Lotan C, Durst R PMID: 26757570 [PubMed – in process] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1PZSxdu via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PtfVgN via IFTTT
Hepatitis C Virus in Children: Deferring Treatment in Expectation of Direct-Acting Antiviral Agents.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Hepatitis C Virus in Children: Deferring Treatment in Expectation of Direct-Acting Antiviral Agents. Isr Med Assoc J. 2015 Nov;17(11):707-11 Authors: Granot E, Sokal EM Abstract The major route of hepatitis C virus (HCV) infection in the pediatric age group is vertical, with infection occurring in up to 5% of infants born to mothers positive for […]
Adenocarcinoma of the Gallbladder: Incidental Finding in Patients following Laparoscopic Sleeve Gastrectomy and Cholecystectomy.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Adenocarcinoma of the Gallbladder: Incidental Finding in Patients following Laparoscopic Sleeve Gastrectomy and Cholecystectomy. Isr Med Assoc J. 2015 Nov;17(11):703-6 Authors: Raziel A, Sakran N, Szold A, Sandbank J, Hershko D, Goitein D Abstract BACKGROUND: Gallbladder (GB) cancer is rare. Most cases are incidentally found in specimens after a cholecystectomy. Cholelithiasis is almost always present […]
Meningitis and Meningoencephalitis among Israel Defense Force Soldiers: 20 Years Experience at the Hadassah Medical Centers.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Meningitis and Meningoencephalitis among Israel Defense Force Soldiers: 20 Years Experience at the Hadassah Medical Centers. Isr Med Assoc J. 2015 Nov;17(11):697-702 Authors: Pikkel YY, Ben-Hur T, Eliahou R, Honig A Abstract BACKGROUND: Meningitis and meningoencephalitis pose major risks of morbidity and mortality. OBJECTIVES: To describe 20 years of experience treating infections of the central […]
JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects.
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
JAG1 loss-of-function variations as a novel predisposing event in the pathogenesis of congenital thyroid defects. J Clin Endocrinol Metab. 2016 Jan 13;:jc20153403 Authors: de Filippis T, Marelli F, Nebbia G, Porazzi P, Corbetta S, Fugazzola L, Gastaldi R, Vigone MC, Biffanti R, Frizziero D, Mandarà L, Prontera P, Salerno M, Maghnie M, Tiso N, Radetti […]
Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Estradiol rapidly regulates the activity of arcuate nucleus (ARH) proopiomelanocortin (POMC) neurons that project to the medial preoptic nucleus (MPN) to regulate lordosis. Orphanin FQ/nociceptin (OFQ/N) acts via opioid receptor-like (ORL)-1 receptors to inhibit these POMC neurons. Therefore, we tested the hypothesis that estradiol excites POMC neurons by rapidly attenuating inhibitory ORL-1 signaling in these […]
The Sensitivity of Heavy Precipitation to Horizontal Resolution, Domain Size, and Rain Rate Assimilation: Case Studies with a Convection-Permitting Model
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Australian Community Climate and Earth-System Simulator (ACCESS) is used to test the sensitivity of heavy precipitation to various model configurations: horizontal resolution, domain size, rain rate assimilation, perturbed physics, and initial condition uncertainties, through a series of convection-permitting simulations of three heavy precipitation (greater than 200 mm day−1) cases in different synoptic backgrounds. The larger disparity […]
A New Small Drifter for Shallow Water Basins: Application to the Study of Surface Currents in the Muggia Bay (Italy)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A new small drifter prototype for measuring current immediately below the free surface in a water basin is proposed in this paper. The drifter dimensions make it useful for shallow water applications. The drifter transmits its GPS location via GSM phone network. The drifter was used to study the trajectory of the surface current in […]
Modeling and Simulation of the Hydrogenation of α-Methylstyrene on Catalytically Active Metal Foams as Tubular Reactor Packing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
This work presents a one-dimensional reactor model for a tubular reactor packed with a catalytically active foam packing with a pore density of 30 PPI in cocurrent upward flow in the example of hydrogenation reaction of α-methylstyrene to cumene. This model includes material, enthalpy, and momentum balances as well as continuity equations. The model was solved […]
Synthesis of New Energetic Materials and Ionic Liquids Derived from Metronidazole
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Simple and efficient synthetic procedures were established for the preparation of new energetic covalent compounds, salts, and protonated ionic liquids based on the readily available antimicrobial agent metronidazole. Some of these materials exhibit the desirable properties of energetic materials and energetic ionic liquids, such as low vapor pressure, low melting point, good chemical and thermal […]
Prediction Accuracy in Multivariate Repeated-Measures Bayesian Forecasting Models with Examples Drawn from Research on Sleep and Circadian Rhythms
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In study designs with repeated measures for multiple subjects, population models capturing within- and between-subjects variances enable efficient individualized prediction of outcome measures (response variables) by incorporating individuals response data through Bayesian forecasting. When measurement constraints preclude reasonable levels of prediction accuracy, additional (secondary) response variables measured alongside the primary response may help to increase […]
Detection of Myofascial Herniation on Dynamic Sonography and Magnetic Resonance Imaging
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Muscle hernia is an uncommon cause of leg swelling. It can be detected in the early stages only if there is a high index of suspicion. It is common in lower extremity compared to the upper extremity. Tibialis anterior muscle in the leg is commonly involved. Dynamic sonography and magnetic resonance imaging (MRI) are the […]
Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 13 January 2016 Source:Free Radical Biology and Medicine Author(s): Shaun A. Mason, Paul A. Della Gatta, Rod J. Snow, Aaron P. Russell, Glenn D. Wadley Aim/hypothesisSkeletal muscle insulin resistance and oxidative stress are characteristic metabolic disturbances in people with type 2 diabetes. Studies in insulin resistant rodents show an improvement in […]
Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: March 2016 Source:Free Radical Biology and Medicine, Volume 92 Author(s): Vladimir F. Lazarev, Alina D. Nikotina, Pavel I. Semenyuk, Diana B. Evstafyeva, Elena R. Mikhaylova, Vladimir I. Muronetz, Maxim A. Shevtsov, Anastasia V. Tolkacheva, Anatoly V. Dobrodumov, Alexey L. Shavarda, Irina V. Guzhova, Boris A. Margulis Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is one of the […]
Oxidised LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Publication date: Available online 14 January 2016 Source:Free Radical Biology and Medicine Author(s): Deepika Awasthi, Sheela Nagarkoti, Amit Kumar, Megha Dubey, Abhishek Kumar Singh, Priya Pathak, Tulika Chandra, Manoj Kumar Barthwal, Madhu Dikshit Neutrophil extracellular traps (NETs) formation was initially linked with host defence and extracellular killing of pathogens. However, recent studies have highlighted their […]
Results from the phase 2 terrain trial of enzalutamide compared to bicalutamide in metastatic castration-resistant prostate cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Results from the Phase 2 TERRAIN trial of enzalutamide compared to bicalutamide in metastatic castration-resistant prostate cancer (mCRPC) were published in the Lancet Oncology. The article, titled, “Efficacy and Safety of Enzalutamide Versus… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Q7LHVm via IFTTT
Pitfalls and Solutions in Virtual Design of Nasoalveolar Molding Plates by Using CAD/CAM Technology – a Preliminary Clinical Study
Publication date: Available online 14 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Lucas M. Ritschl, Andrea Rau, Florian D. Güll, Benjamin diBora, Klaus-Dietrich Wolff, Markus Schönberger, Franz X. Bauer, Erich Wintermantel, Denys J. Loeffelbein Computer-assisted design and computer-aided manufacturing (CAD/CAM) technology in nasoalveolar molding (NAM) should save time and manpower and reduce family input in cases of cleft lip and palate.Intraoral casts from twelve infants with complete unilateral cleft lip and palate were taken immediately after birth (T... περισσότερα »
An anatomical study of the pathophysiology of carotid cavernous sinus fistula associated with Le Fort III osteotomy
Publication date: Available online 14 January 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Yuuki Uchida, Nobuyuki Mitsukawa, Shinsuke Akita, Kaneshige Satoh, Takane Suzuki, Chisato Mori Carotid-cavernous sinus fistula (CCF) is a rare complication occurring after the Le Fort osteotomy. We aimed to elucidate the cause of CCF in the Le Fort osteotomy.MethodsEleven fresh cadavers were used. After craniotomy, a Le Fort III bipartition osteotomy was then performed. On the left side, both the lateral wall of the maxilla and the pterygomaxillary junction (PMJ) were divid...περισσότερα »
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
Publication date: Available online 14 January 2016 *Source:*Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, nor for effects of electrical stimulation, such as spectral smearing as a function of stimulus intensity. In this paper, a neural model that accounts for stochastic firing, para...περισσότερα »
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
Publication date: Available online 14 January 2016 *Source:*Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, nor for effects of electrical stimulation, such as spectral smearing as a function of stimulus intensity. In this paper, a neural model that accounts for stochastic firing, para...περισσότερα »
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
Publication date: Available online 14 January 2016 *Source:*Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, nor for effects of electrical stimulation, such as spectral smearing as a function of stimulus intensity. In this paper, a neural model that accounts for stochastic firing, para...περισσότερα »
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
Publication date: Available online 14 January 2016 *Source:*Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, nor for effects of electrical stimulation, such as spectral smearing as a function of stimulus intensity. In this paper, a neural model that accounts for stochastic firing, para...περισσότερα »
A Neural-Based Vocoder Implementation for Evaluating Cochlear Implant Coding Strategies
Publication date: Available online 14 January 2016 *Source:*Hearing Research Author(s): Nawal El Boghdady, Andrea Kegel, Wai Kong Lai, Norbert Dillier Most simulations of cochlear implant (CI) coding strategies rely on standard vocoders that are based on purely signal processing techniques. However, these models neither account for various biophysical phenomena, such as neural stochasticity and refractoriness, nor for effects of electrical stimulation, such as spectral smearing as a function of stimulus intensity. In this paper, a neural model that accounts for stochastic firing, para...περισσότερα »
Q Fever Manifested as Acalculous Cholecystitis.
*Q Fever Manifested as Acalculous Cholecystitis.* Isr Med Assoc J. 2015 Nov;17(11):714-6 Authors: Simons M, Heyman SN, Bursztyn M, Shalev O, Hiller N, Israel S PMID: 26757571 [PubMed - in process] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1RGveJC via IFTTT
Lymphoma of the Right Atrium and Ventricle.
*Lymphoma of the Right Atrium and Ventricle.* Isr Med Assoc J. 2015 Nov;17(11):712-3 Authors: Chen S, Atlan K, Gilon D, Lotan C, Durst R PMID: 26757570 [PubMed - in process] from #PubMed 2 via ola Kala on Inoreader http://ift.tt/1PZSxdu via IFTTT
Hepatitis C Virus in Children: Deferring Treatment in Expectation of Direct-Acting Antiviral Agents.
*Hepatitis C Virus in Children: Deferring Treatment in Expectation of Direct-Acting Antiviral Agents.* Isr Med Assoc J. 2015 Nov;17(11):707-11 Authors: Granot E, Sokal EM Abstract The major route of hepatitis C virus (HCV) infection in the pediatric age group is vertical, with infection occurring in up to 5% of infants born to mothers positive for HCV-RNA. The natural course of pediatric HCV infection is characterized by a high rate of spontaneous clearance, an asymptomatic clinical course, and normal or mild histologic changes. Cirrhosis is reported in 1-2% of children, and pro... περισσότερα »
Adenocarcinoma of the Gallbladder: Incidental Finding in Patients following Laparoscopic Sleeve Gastrectomy and Cholecystectomy.
*Adenocarcinoma of the Gallbladder: Incidental Finding in Patients following Laparoscopic Sleeve Gastrectomy and Cholecystectomy.* Isr Med Assoc J. 2015 Nov;17(11):703-6 Authors: Raziel A, Sakran N, Szold A, Sandbank J, Hershko D, Goitein D Abstract BACKGROUND: Gallbladder (GB) cancer is rare. Most cases are incidentally found in specimens after a cholecystectomy. Cholelithiasis is almost always present when this diagnosis is made. Obesity is a known risk factor for gallstone formation and thus may be related to GB cancer. OBJECTIVES: To highlight the importance of evaluating the ...περισσότερα »
Meningitis and Meningoencephalitis among Israel Defense Force Soldiers: 20 Years Experience at the Hadassah Medical Centers.
*Meningitis and Meningoencephalitis among Israel Defense Force Soldiers: 20 Years Experience at the Hadassah Medical Centers.* Isr Med Assoc J. 2015 Nov;17(11):697-702 Authors: Pikkel YY, Ben-Hur T, Eliahou R, Honig A Abstract BACKGROUND: Meningitis and meningoencephalitis pose major risks of morbidity and mortality. OBJECTIVES: To describe 20 years of experience treating infections of the central nervous system in Israel Defense Force (IDF) soldiers, including the common presentations, pathogens and sequelae, and to identify risk groups among soldiers. METHODS: All soldiers who ... περισσότερα »
Visual Analogue Scales of Pain, Fatigue and Function in Patients with Various Rheumatic Disorders Receiving Standard Care.
*Visual Analogue Scales of Pain, Fatigue and Function in Patients with Various Rheumatic Disorders Receiving Standard Care.* Isr Med Assoc J. 2015 Nov;17(11):691-6 Authors: Levy O, Amit-Vazina M, Segal R, Tishler M Abstract BACKGROUND: Pain, fatigue and functional disability are common key outcomes in most rheumatologic disorders. While many studies have assessed the outcomes of specific disease states, few have compared the outcomes of various rheumatic diseases. OBJECTIVES: To assess how the intensity and rating of pain, fatigue and functional disability vary among groups of pa... περισσότερα »
Primary Ovarian Pregnancy: 43 Years Experience in a Single Institute and still a Medical Challenge.
*Primary Ovarian Pregnancy: 43 Years Experience in a Single Institute and still a Medical Challenge.* Isr Med Assoc J. 2015 Nov;17(11):687-90 Authors: Melcer Y, Smorgick N, Vaknin Z, Mendlovic S, Raziel A, Maymon R Abstract BACKGROUND: Despite awareness regarding tubal pregnancy, ovarian pregnancy still remains a diagnostic challenge. The correct diagnosis is most frequently made intraoperatively and requires histopathologic confirmation. Therefore, additional diagnostic measurements are needed for earlier and more accurate detection of ovarian pregnancies which will allow more r... περισσότερα »
Endothelial Function Assessment in Patients with Erectile Dysfunction.
*Endothelial Function Assessment in Patients with Erectile Dysfunction.* Isr Med Assoc J. 2015 Nov;17(11):682-6 Authors: Bahouth Z, Zreik R, Graif A, Nativ O, Halachmi S, Pillar G Abstract BACKGROUND: Erectile dysfunction (ED), a common problem in males of all ages, can be of organic, psychogenic or combined etiology. Organic ED is mainly caused by vascular and neurological disorders. One of the available tests for differentiating organic from inorganic ED is measuring penile tumescence and rigidity during the REM phase of sleep. However, this test lacks the ability to differenti...περισσότερα »
Role of Plain Abdominal Radiographs in the Evaluation of Patients with Non-Traumatic Abdominal Pain.
*Role of Plain Abdominal Radiographs in the Evaluation of Patients with Non-Traumatic Abdominal Pain.* Isr Med Assoc J. 2015 Nov;17(11):678-81 Authors: Zeina AR, Shapira-Rootman M, Mahamid A, Ashkar J, Abu-Mouch S, Nachtigal A Abstract BACKGROUND: Plain abdominal radiographs are still performed as a first imaging examination to evaluate abdominal pain in the emergency department (ED), despite uncertainty regarding their utility. OBJECTIVES: To describe the frequency and outcomes of the use of plain abdominal radiographs in the diagnosis of patients presenting with acute non-trau... περισσότερα »
Apparent Life-Threatening Events: Patients' Health Status at 5 Years of Age.
*Apparent Life-Threatening Events: Patients' Health Status at 5 Years of Age.* Isr Med Assoc J. 2015 Nov;17(11):673-7 Authors: Steiman B, Watemberg N Abstract BACKGROUND: The long-term significance of apparent life-threatening events (ALTE) has not been thoroughly studied. OBJECTIVES: To evaluate, at age 5 years, the health status of consecutive children diagnosed with ALTE in infancy. METHODS: Based on the diagnostic workup, patients were classified into two groups: a 'broad' evaluation group (at least one test/procedure related to each of the five main causes: infectious, metab...περισσότερα »
Atrial Tachycardia in Patients with Cryptogenic Stroke: Is there a Need For Anticoagulation?
*Atrial Tachycardia in Patients with Cryptogenic Stroke: Is there a Need For Anticoagulation?* Isr Med Assoc J. 2015 Nov;17(11):669-72 Authors: Fuchs T, Torjman A Abstract BACKGROUND: Brief episodes of atrial tachycardia are a common finding in the Holter monitor recordings of elderly patients. Episodes of atrial tachycardia may convert to atrial fibrillation. Current guidelines do not recommend anti-coagulant therapy in patients with atrial tachycardia and risk factors for embolism. OBJECTIVES: To assess the incidence of atrial tachycardia in a 24 hour Holter monitor recording ...περισσότερα »
In vitro effects of recombinant adenovirus-mediated bone morphogenetic protein 2/vascular endothelial growth factor 165 on osteogenic differentiation of bone marrow mesenchymal stem cells.
*In vitro effects of recombinant adenovirus-mediated bone morphogenetic protein 2/vascular endothelial growth factor 165 on osteogenic differentiation of bone marrow mesenchymal stem cells.* Artif Cells Nanomed Biotechnol. 2016 Jan 13;:1-7 Authors: Han TY, Liu XW, Liang N, Liu YE, Zhang YB, Zhou DP, Xiang LB Abstract Mouse bone marrow mesenchymal stem cells C3H10T1/2 were divided into Ad-BMP2 (bone morphogenetic protein 2) group, Ad-VEGF165 (vascular endothelial growth factor 165) group, Ad-VEGF165 + Ad-BMP2 group, empty adenovirus group and control group. BMP2 and VEGF165 were h... περισσότερα »
Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.
*Comparative assessment of humoral immune responses of aluminum hydroxide and oil-emulsion adjuvants in Influenza (H9N2) and Newcastle inactive vaccines to chickens.* Artif Cells Nanomed Biotechnol. 2016 Jan 13;:1-6 Authors: Jafari M, Moghaddam Pour M, Taghizadeh M, Masoudi S, Bayat Z Abstract Context Adjuvants are compounds used in the preparation of inactive vaccines to enhance the immune response. Aluminum hydroxide (alum) is one of the first compounds approved by the Food and Drug Administration, which is used as adjuvants in vaccine products for humans. Montanide ISA 70 is a... περισσότερα »
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