Diagnostic challenge of desmoplastic melanoma
Desmoplastic melanoma (DM) is a rare variant of spindle-cell malignant melanoma. DM is easily misdiagnosed at an early stage because it can be confused with benign entities. Histological analysis, including careful attention to the presence of atypical spindle cells, as well as to lymphocytic aggregates in an abundant fibrotic stroma in the dermis, provides clues for diagnosis. The adjunction of an immunohistochemical panel, and particularly testing for S-100 protein, is needed for the final diagnosis. from melanoma2 via als.fakia on Inoreader http://ift.tt/1MDE21c via IFTTT
Diagnostic challenge of desmoplastic melanoma
Desmoplastic melanoma (DM) is a rare variant of spindle-cell malignant melanoma. DM is easily misdiagnosed at an early stage because it can be confused with benign entities. Histological analysis, including careful attention to the presence of atypical spindle cells, as well as to lymphocytic aggregates in an abundant fibrotic stroma in the dermis, provides clues for diagnosis. The adjunction of an immunohistochemical panel, and particularly testing for S-100 protein, is needed for the final diagnosis. from melanoma2 via als.fakia on Inoreader http://ift.tt/1MDE21c via IFTTT
CNS prophylaxis with intrathecal liposomal cytarabine
Central nervous system prophylaxis with intrathecal liposomal cytarabine in a subset of high-risk patients with diffuse large B-cell lymphoma receiving first line systemic therapy in a prospective trial: AbstractThe dissemination in the central nervous system (CNS) is an uncommon but fatal complication occurring in patients with diffuse large B-cell lymphoma (DLBCL). Standard prophylaxis has been demonstrated to reduce CNS relapse and improve survival rates. Intrathecal (IT) liposomal cytarabine allows maintaining elevated drug levels in the cerebrospinal fluid for an extended peri... περισσότερα »
Mantle Cell Lymphoma
[REVIEW ARTICLE]: Mantle cell lymphoma (MCL) is an uncommon subtype of non-Hodgkin lymphoma previously considered to have a poor prognosis. Large gains were made in the first decade of the new century when clinical trials established the importance of high-dose therapy and autologous stem-cell rescue and high-dose cytarabine in younger patients and the benefits of maintenance rituximab and bendamustine in older patients. In particular, greater depth of understanding of the molecular pathophysiology of MCL has resulted in an explosion of specifically targeted new efficacious agents.... περισσότερα »
Hearing Loss in Patients Who Received Cranial Radiation Therapy
for Childhood Cancer [Treatment-Related Complications]: Purpose Patients treated with cranial radiation therapy (RT) are at risk for sensorineural hearing loss (SNHL). Although SNHL is often characterized as a delayed consequence of anticancer therapy, longitudinal reports of SNHL in childhood cancer survivors treated with contemporary RT are limited. We report the incidence, onset, severity, and long-term trajectory of SNHL among children receiving RT. Potential risk factors for SNHL were also identified. Patients and Methods Serial audiologic testing was conducted on 235 pediatr... περισσότερα »
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma
Disintegrin and metalloproteinases (ADAMs) expression in gastroesophageal reflux disease and in esophageal adenocarcinoma: Abstract BackgroundClinically useful marker molecules for the progression of gastroesophageal reflux disease and Barrett’s esophagus (BE) to esophageal adenocarcinoma (EAC) are lacking. Many adenocarcinomas and inflammatory conditions exhibit increased expression of ADAMs, ‘a disintegrin and metalloproteinases’. MethodsWe assessed the expression of five ADAMs (9, 10, 12, 17, 19) in three esophageal cell lines (Het-1A, OE19, OE33) by RT-PCR and Western blot... περισσότερα »
Seven days in medicine: 23-29 March
Around the UKDoctors question UK’s FGM policySince 2015 anyone under 18 identified with female genital mutilation (FGM) in the United Kingdom must be reported to the police, but this mandatory… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PHraBK via IFTTT
Beyond the mainstream
“There is very little science in shaken baby syndrome. It’s become a label. We’re not there at the time of collapse. We don’t know if these babies have been shaken.” So said Waney Squier, the… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1VUZYHg via IFTTT
How to translate clinical trial results into gain in healthy life expectancy for individual patients
Summary pointsGain in disease-free life expectancy is a more intuitive measure of treatment effect than number needed to treat for lifelong treatment for chronically progressive conditionsTreatment… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PHr90F via IFTTT
Diabetes treatments and risk of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia: open cohort study in primary care
Objective To assess the risks of amputation, blindness, severe kidney failure, hyperglycaemia, and hypoglycaemia in patients with type 2 diabetes associated with prescribed diabetes drugs,… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1VUZUY4 via IFTTT
The Greater Manchester experiment
Clarification—In the third paragraph of this feature (BMJ 2016;352:i1611, doi:10.1136/bmj.i1611), we should have written that the Taking Charge strategy [for devolution of control of the health and… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PHr8d9 via IFTTT
A patient with muscle weakness
A 29 year old woman presented with symptoms of muscle weakness and difficulty swallowing. Physical examination showed swollen upper eyelids with a violaceous eruption (fig 1). The dorsal side of her… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1VUZSzp via IFTTT
Wnt-11 overexpression promoting the invasion of cervical cancer cells
Abstract Wnt-11 is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. However, Wnt-11 expression in cervical cancer has not been well investigated. The aim of this study was to investigate the role of Wnt-11 in cervical tumor proliferation and invasion. This study examined 24 normal cervical squamous epithelia,… Continue reading Wnt-11 overexpression promoting the invasion of cervical cancer cells
IJMS, Vol. 17, Pages 479: Different Serum Free Fatty Acid Profiles in NAFLD Subjects and Healthy Controls after Oral Fat Load
Background: Free fatty acid (FFA) metabolism can impact on metabolic conditions, such as obesity and nonalcoholic fatty liver disease (NAFLD). This work studied the increase in total FFA shown in NAFLD subjects to possibly characterize which fatty acids significantly accounted for the whole increase. Methods: 21 patients with NAFLD were selected according to specified criteria.… Continue reading IJMS, Vol. 17, Pages 479: Different Serum Free Fatty Acid Profiles in NAFLD Subjects and Healthy Controls after Oral Fat Load
IJMS, Vol. 17, Pages 476: The Honolulu Liver Disease Cluster at the Medical Center: Its Mysteries and Challenges
In 2013, physicians at the Honolulu Queen’s Medical Center (QMC) noticed that seven liver disease patients reported the use of OxyELITE Pro (OEP), a widely consumed dietary supplement (DS). Assuming a temporal association between OEP use and disease, they argued that OEP was the cause of this mysterious cluster. Subsequent reexamination, however, has revealed that… Continue reading IJMS, Vol. 17, Pages 476: The Honolulu Liver Disease Cluster at the Medical Center: Its Mysteries and Challenges
Prognostic Role of Multiple Lymphatic Basin Drainage in Sentinel Lymph Node-Negative Trunk Melanoma Patients:
A Multicenter Study from the Italian Melanoma Intergroup: Abstract BackgroundMultiple lymphatic basin drainage (MLBD) is frequently observed in patients with trunk melanoma undergoing sentinel lymph node (SLN) biopsy. Conflicting data regarding the prognostic association of MLBD in SLN-negative patients have been reported. This study aimed to investigate the prognostic role of MLBD in patients with negative SLN biopsy. MethodsRetrospective data from 656 melanoma patients who underwent a SLN biopsy (1991–2012) at six Italian centers were gathered in a multicenter database. MLBD ...περισσότερα »
Prognostic Significance of Lymph Node Ratio in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck
Prognostic Significance of Lymph Node Ratio in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck: Abstract BackgroundThe prognostic variables in patients with metastatic cutaneous nodal squamous cell carcinoma (SCC) are well documented; however, the relationship between lymph node ratio (LNR) and outcome is not well researched. LNR represents the ratio of positive lymph nodes to total excised lymph nodes. We analyzed the correlation between LNR and outcome in patients who have undergone surgery for metastatic cutaneous nodal SCC of the head and neck. MethodsAna...περισσότερα »
Angiosarcoma arising in the setting of chronic lymphedema
Stewart-Treves Syndrome: A Case Report and Review of the Literature: The Stewart-Treves syndrome is a rare and deadly entity, which is defined as angiosarcoma arising in the setting of chronic lymphedema. It typically presents in women who develop lymphedema in the upper extremity secondary to axillary lymph node dissection for breast cancer surgery. It is extremely uncommon in the lower extremities as a result of idiopathic chronic lymphedema. Here, we present the case of a 63-year-old female patient with idiopathic chronic lymphedema of the lower extremities having morbid obesity ...περισσότερα »
Submit to our new cross-journal thematic series, 'Advances in Neuroimaging'
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 11 δευτερόλεπτα
[image: BioMed Central – The Open Access Publisher] Cancer An update from BioMed Central March 2016 New Thematic Series: Advances in Neuroimaging An update from BioMed Central March 2016 Dear Dr Sfakianakis, We are pleased to invite you to submit to a new cross-journal thematic series. ------------------------------ Advances in Neuroimaging: Insights into Neurological and Psychiatric Disease [image: Advances in Neuroimaging: Insights into Neurological and Psychiatric Disease] The major goal of this series is to present an overview of state-of-the-art ad... περισσότερα »
Acrylamide in Food and Cancer Risk : Food and cigarette smoke are the major sources of acrylamide exposure : Potato chips and French fries
*- [image: Resize font]- [image: Print]- [image: Email]- [image: Facebook]- [image: Twitter]- [image: Google+]- ON THIS PAGE* - *What is acrylamide? * - *Is there acrylamide in food? * - *How does cooking produce acrylamide? * - *Is there anything in the cooking process that can be changed to lower dietary acrylamide exposure?* - *Should I change my diet? * - *Are there other ways humans are exposed to acrylamide? * - *Does acrylamide increase the risk of cancer?* - *What are other health effects of acrylamide?* - *Are acrylamide levels regulated? *... περισσότερα »
Inhibitory Effects of AVEMAR on Proliferation and Metastasis of Oral Cancer Cells
Inhibitory Effects of AVEMAR on Proliferation and Metastasis of Oral Cancer Cells: 10.1080/01635581.2016.1153668<br>Mei-Due Yang ABSTRACT Oral cancer is keeping its 4th rank on the death causing cancers among Taiwan males, and its metastatic and recurrent rates remain high and a life-threatening issue to the citizens. Fermented wheat germ extract (AVEMAR) is used in clinical cancer nutritional therapy in gastrointestinal cancers but not in oral cancer yet. In this study, the potential of AVEMAR to inhibit tumor proliferation and metastasis of oral cancer was first investigated. ... περισσότερα »
Long-Term Outcome Data in Patients following One Year's Use of a Fully Implantable Active Middle Ear Implant
This study examined the safety and efficacy of a fully implantable active middle ear (AMEI) system. Outcome measures assessed AMEI performance compared with an optimally fitted conventional hearing aid (CHA). Fifty adults with stable, symmetric moderate-to-severe sensorineural hearing loss were implanted at 9 ambulatory settings. Consonant-Nucleus-Consonant (CNC) words, Bamford-Kowel-Bench Speech in Noise test (BKB-SIN), Abbreviated Profile of Hearing Aid Benefit (APHAB), and unaided hearing thresholds in the implanted ear were compared to baseline measures obtained using a person... περισσότερα »
Sucralfate Mouth Wash in Prevention of 5-fluorouracil Induced Oral Mucositis
A Prospective, Randomized, Double-Blind, Controlled Trial: 10.1080/01635581.2016.1153666<br>Shahram Ala ABSTRACT Sucralfate has been used for the prevention and treatment of radiotherapy- and chemotherapy-induced stomatitis and mucositis in a number of studies, but the results are contradictory. To answer such discrepancies, the present study was designed to evaluate the efficacy of sucralfate mouthwash in prevention of 5-fluorouracil (5-FU)-induced oral mucositis in patients with gastrointestinal malignancies. Patients with gastrointestinal cancers receiving 5-FU-based chemothe...περισσότερα »
Molecules, Vol. 21, Pages 364: Physicochemical Properties of Defatted Rambutan (Nephelium lappaceum) Seed Flour after Alkaline Treatment
Rambutan seeds were subjected to SC-CO2 extraction at 35 MPa, 45 °C to obtain defatted rambutan seed flour. Its physicochemical properties before and after treatment with alakali solution using 0.075 N NaOH were investigated. Alkali-treated flour had a significant increment in bulk density, swelling power, water adsorption capacity, emulsion capacity and stability but a reduction in turbidity, solubility and oil absorption capacity. Pasting measurements showed peak viscosity, breakdown, setback and final viscosity increased significantly for the alkali-treated flour, while pasting... περισσότερα »
Proteomes, Vol. 4, Pages 14: The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease
The early diagnosis of Alzheimer's disease (AD) has become important to the reversal and treatment of neurodegeneration, which may be relevant to premature brain aging that is associated with chronic disease progression. Clinical proteomics allows the detection of various proteins in fluids such as the urine, plasma, and cerebrospinal fluid for the diagnosis of AD. Interest in lipidomics has accelerated with plasma testing for various lipid biomarkers that may with clinical proteomics provide a more reproducible diagnosis for early brain aging that is connected to other chronic di... περισσότερα »
Molecules, Vol. 21, Pages 437: Identification of Oxygenated Fatty Acid as a Side Chain of Lipo-Alkaloids in Aconitum carmichaelii by UHPLC-Q-TOF-MS and a Database
Lipo-alkaloid is a kind of C19-norditerpenoid alkaloid usually found in Aconitum species. Structurally, they contain an aconitane skeleton and one or two fatty acid moieties of 3–25 carbon chains with 1–6 unsaturated degrees. Analysis of the lipo-alkaloids in roots of Aconitum carmichaelii resulted in the isolation of six known pure lipo-alkaloids (A1–A6) and a lipo-alkaloid mixture (A7). The mixture shared the same aconitane skeleton of 14-benzoylmesaconine, but their side chains were determined to be 9-hydroxy-octadecadienoic acid, 13-hydroxy-octadecadienoic acid and 10-hydroxy-... περισσότερα »
Entropy, Vol. 18, Pages 121: A Kinetic Perspective on k - ϵ Turbulence Model and Corresponding Entropy Production
In this paper, we present an alternative derivation of the entropy production in turbulent flows, based on a formal analogy with the kinetic theory of rarefied gas. This analogy allows for proving that the celebrated k - ϵ model for turbulent flows is nothing more than a set of coupled BGK (Bhatnagar–Gross–Krook)-like equations with a proper forcing. This opens a novel perspective on this model, which may help in sorting out the heuristic assumptions essential for its derivation, such as the balance between turbulent kinetic energy production and dissipation. The entropy productio... περισσότερα »
Molecules, Vol. 21, Pages 432: On the High Sensitivity of the Electronic States of 1 nm Gold Particles to Pretreatments and Modifiers
In this paper, the effect of modifiers and pretreatments on the electronic states of 1 nm gold nanoparticles (AuNPs) supported on silica was systematically studied. AuNPs deposited on silica (particle size of 2–4 nm) modified with Ce, La and Fe oxides, were studied by FTIR of adsorbed CO after different redox treatments at 100, 300 and 500 °C. This study was conducted at room temperature to allow detecting the electronic states of gold, which is more likely involved in CO oxidation at the same temperature. AuNP size distribution was measured by HRTEM. It is shown that the electron...περισσότερα »
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
*Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. STUDY DESIGN: Prospective clinical study. SETTING: Multicenter, tertiary care hospitals. SUBJECTS AND METHODS: The age range of the 28 participants was 22 to 47 yea... περισσότερα »
Sudden-Onset Sensorineural Hearing Loss after Immunization: A Case-Centered Analysis.
*Sudden-Onset Sensorineural Hearing Loss after Immunization: A Case-Centered Analysis.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Baxter R, Lewis N, Bohrer P, Harrington T, Aukes L, Klein NP Abstract OBJECTIVE: Case reports of sudden sensorineural hearing loss (SSHL) following vaccines have led to concerns that vaccines may rarely cause hearing loss. Because of this concern, we analyzed for an association between SSHL and vaccinations. STUDY DESIGN: We used a case-centered method, equivalent to a case control design using immunization dates from all matched members of the ...περισσότερα »
Prevalence of Voice Disturbances in the Pediatric Craniofacial Patient Population.
*Prevalence of Voice Disturbances in the Pediatric Craniofacial Patient Population.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Fritz MA, Rickert SM Abstract OBJECTIVE: To report on the prevalence of voice disturbances in the pediatric craniofacial population and to prove that the pediatric Voice Handicap Index (pVHI) is a useful questionnaire for this unique population. STUDY DESIGN: Case series with chart review. SETTING: Tertiary care center. SUBJECTS: Pediatric patients seen by a pediatric otolaryngologist in a craniofacial clinic. METHODS: Consecutive patients (N = 366)... περισσότερα »
Survival and Prognosis for Malignant Tumors of Odontogenic Origin.
*Survival and Prognosis for Malignant Tumors of Odontogenic Origin.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Agarwal S, Mark J, Xie C, Ghulam E, Patil Y Abstract OBJECTIVE: Determine survival and factors affecting survival for patients with malignant tumors of odontogenic origin. STUDY DESIGN: Retrospective analysis of the National Cancer Institute's SEER database (Surveillance, Epidemiology, and End Results). SETTING: Tertiary medical center. SUBJECTS AND METHODS: All cases of malignant tumors of odontogenic origin were extracted from the SEER database for the period of 1... περισσότερα »
Resveratrol in lymphoid malignancies
Therapeutic potential of resveratrol in lymphoid malignancies.: Nutr Cancer. 2016 Mar 30;:1-9 Authors: Khan OS, Bhat AA, Krishnankutty R, Mohammad RM, Uddin S Abstract Natural products have always been sought as a dependable source for the cure of many fatal diseases including cancer. Resveratrol (RSV), a naturally occurring plant polyphenol, has been of recent research interest and is being investigated for its beneficial biological properties that include antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory activities. These effects are mainly mediated by cell cycl... περισσότερα »
Subclinical hyperthyroidism: First do no harm
Subclinical hyperthyroidism: First do no harm: Abstract The consequences of overt thyrotoxicosis, including an increased risk of cardiac dysrhythmias, cardiovascular disease and osteoporosis, are well recognised. It is the awareness of these adverse clinical outcomes in the longer term, coupled with the need to manage the unpleasant symptoms of thyrotoxicosis in the short term, that prompts intervention to render the patient euthyroid, either with antithyroid drugs, radioactive iodine or by surgery. However, the consequences of subclinical hyperthyroidism, defined biochemically as ... περισσότερα »
A tablet-interfaced high-resolution microendoscope with automated image interpretation for real-time evaluation of esophageal squamous cell neoplasia
A tablet-interfaced high-resolution microendoscope with automated image interpretation for real-time evaluation of esophageal squamous cell neoplasia: In recent years, high-resolution microendoscopy (HRME) has shown potential to improve screening for esophageal squamous cell neoplasia (ESCN). Furthering its utility in a clinical setting, especially in lower-resource settings, could be accomplished by reducing the size and cost of the system as well as incorporating the ability of real-time, objective feedback. This article describes a tablet-interfaced HRME with fully automated, rea...περισσότερα »
Per-oral endoscopic myotomy (with video)
Per-oral endoscopic myotomy (with video): The American Society for Gastrointestinal Endoscopy (ASGE) Technology Committee provides reviews of existing, new, or emerging endoscopic technologies that have an impact on the practice of GI endoscopy. Evidence-based methodology is used by performing a MEDLINE literature search to identify pertinent clinical studies on the topic as well as a U.S. Food and Drug Administration Center for Devices and Radiological Health (MAUDE) database search to identify the reported complications of a given technology.
Wnt-11 overexpression promoting the invasion of cervical cancer cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
Abstract Wnt-11 is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. However, Wnt-11 expression in cervical cancer has not been well investigated. The aim of this study was to investigate the role of Wnt-11 in cervical tumor proliferation and invasion. This study examined 24 normal cervical squamous epithelia, […]
Finding the optimal deconvolution algorithm for MR perfusion in carotid stenosis: Correlations with angiographic cerebral circulation time
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 24 δευτερόλεπτα
Publication date: Available online 30 March 2016 Source:Journal of Neuroradiology Author(s): Chung-Jung Lin, Sheng-Che Hung, Feng-Chi Chang, Wan-Yuo Guo, Chao-Bao Luo, Markus Kowarschik, Wei-Fa Chu, Adrian J.Y. Kang Liou PurposeThe aim of our study is to explore the impacts of different deconvolution algorithms on correlations between CBF, MTT, CBV, TTP, Tmax from MR perfusion (MRP) […]
Epithelioid Hemangioendothelioma: a Rare Primary Thyroid Tumor with Confirmation of WWTR1 and CAMTA1 Rearrangements
Epithelioid Hemangioendothelioma: a Rare Primary Thyroid Tumor with Confirmation of WWTR1 and CAMTA1 Rearrangements: Abstract We report a rare case of epithelioid hemangioendothelioma as a primary thyroid tumor. To our knowledge, there are only two prior unequivocal cases of primary thyroid epithelioid hemangioendothelioma reported in the English literature. This is the first case in the thyroid with molecular confirmation. KeywordsEpithelioid hemangioendothelioma Thyroid *WWTR1*-*CAMTA1* Vascular Sarcoma
Azelaic acid in melasma treatment
Comparison of efficacy of products containing azelaic acid in melasma treatment: Abstract Background Melasma is one of the most frequently diagnosed hyperpigmentation changes on the skin of women's faces. Nearly 30% of women using oral estrogen therapy struggle with this problem. A common way of reducing melasma is the application of azelaic acid products. Aim Comparison of efficacy of three dermocosmetic products, containing azelaic acid, in the reduction in melasma for women aged 35–55. Material and methods A group of 60 women diagnosed with melasma were divided into three even, t... περισσότερα »
Cutaneus findings in patients with predialysis chronic kidney disease : The most common cutaneous finding was xerosis (64.9%) followed by hair findings (41.4%), pruritus (19.2%), pigmentary changes (17.5%), nail findings (15.3%) and oral mucosal findings (9.3%).
Cutaneuos findings in patients with predialysis chronic kidney disease: Abstract Background Several cutaneous findings are seen in dialysis dependent chronic kidney disease (CKD) patients. However, there are only a few small studies on cutaneous findings in predialysis CKD patients. We aimed to determine cutaneous findings in predialysis CKD patients. Methods This was a cross-sectional study. Consecutive predialysis CKD patients from nephrology outpatient clinic in a university affiliated hospital were recruited to this study. Detailed dermatologic examination was performed by a sen...περισσότερα »
Sun tolerance in patients with erythropoietic protoporphyria
Influence of meteorological data on sun tolerance in patients with erythropoietic protoporphyria in France: Summary Background Erythropoietic protoporphyria (EPP) is a rare metabolic disorder, characterized by photosensitivity, caused by errors of the hæm biosynthetic pathway. Avoidance of sun exposure is recommended; however, some patients suggested a paradoxical improvement of symptoms when they move to sunny areas. Objectives In a national French study, we sought to investigate the influence of sun exposure on EPP symptoms. Methods We used a national transversal observational stu...περισσότερα »
Catastrophic blindness due to injection of steroid in the treatment of keloid scar
Possible way for reduction of reported catastrophic blindness due to injection of steroid in the treatment of keloid scar:
Ottawa 2016 and ANZAHPE Conference
*By Manasi Jiwrajka* The beautiful city of Perth on the Western Coast of Australia hosted the Ottawa 2016 and ANZAHPE conference this year. Delegates from the US, Canada, the UK, Netherlands, Indonesia, Hong Kong, China, South Africa, Australia and many other countries attended this conference. I downloaded the mobile app for this conference prior to my flight from Brisbane to Perth, and got a minute by minute update on the confer[image: edited_IMG_20160322_144637]ence. There were several important medical education themes addressed during this conference from simulation in the c...περισσότερα »
Fall frequency and associated factors among men and women with or at risk for HIV infection.
*Fall frequency and associated factors among men and women with or at risk for HIV infection.* HIV Med. 2016 Mar 29; Authors: Erlandson KM, Plankey MW, Springer G, Cohen HS, Cox C, Hoffman HJ, Yin MT, Brown TT Abstract OBJECTIVES: Falls and fall-related injuries are a major public health concern. HIV-infected adults have been shown to have a high incidence of falls. Identification of major risk factors for falls that are unique to HIV infection or similar to those in the general population will inform development of future interventions for fall prevention. METHODS: HIV-infected ... περισσότερα »
Application of the Transtheoretical Model to Physical Activity in Deaf Individuals.
Related Articles *Application of the Transtheoretical Model to Physical Activity in Deaf Individuals.* Adapt Phys Activ Q. 2015 Jul;32(3):223-40 Authors: Korologou S, Barkoukis V, Lazuras L, Tsorbatzoudis H Abstract The current study used the transtheoretical model (TTM) as a guiding theoretical framework to assess differences in processes of change, decisional balance, and self-efficacy among deaf individuals with different levels of physical activity. Overall, 146 participants (M age = 26.4 yr, SD = 4.28) completed anonymous questionnaires assessing the dimensions of the TTM, s... περισσότερα »
Oral oxybutynin for the treatment of hyperhidrosis
outcomes after one-year follow-up: Abstract Background/Objectives Although many treatments are available to address hyperhidrosis, the results are not always satisfactory. The aim of the study was to assess the effectiveness, optimal dosage regimen and long-term safety of oral oxybutynin in the treatment of hyperhidrosis. Methods A retrospective review was performed on 110 patients who underwent treatment for hyperhidrosis between February 2007 and December 2013. Their response to treatment was evaluated using the hyperhidrosis disease severity scale at baseline, 3 and 12 months. Ad...περισσότερα »
The quadrilobe flap for repairing defects of the nasal tip
Utility of the quadrilobe flap for repairing defects of the nasal tip: Abstract The quadrilobe flap allows the mobilisation of the skin of the upper nose and nasofacial sulcus to the distal nose while avoiding unfavourable tension vectors that would distort the free margin of the ala. We report our experience over the past 3 years in the first case series of quadrilobe flaps for repair of surgical defects on the nose.
Is there a need for non-drug treatments in headaches?
Is there a need for non-drug treatments in headaches?: Jean Schoenen Dear reader, Despite undisputed therapeutic breakthroughs in recent decades, migraine still ranks amongst the top ten human diseases with the greatest number of years lived with disability (1). Several factors explain this top ranking. First, as migraine does not decrease longevity, it can cause disability and needs to be managed during the greater part of the subject’s lifespan. Second, migraine is widely undertreated (2), and even the most disabled subjects may not consult with or not be informed by their practitioner ...περισσότερα »
Compressive Optic Neuropathy by Apical Cavernous Hemangioma
Improved Vision from Severe Compressive Optic Neuropathy by Apical Cavernous Hemangioma: A 59-year-old woman had a 1-year history of right vision loss. Her visual acuity was then 0.01 OD, and the critical flicker frequency (CFF) was 8 Hz OD. Goldmann perimetry examination showed inferior suppression of the right visual field center. Funduscopic examination revealed normal coloring of the right optic disc. Imaging studies showed an apical oval tumor. The optic nerve was compressed by both the tumor and the superior rectus muscle/levator palpebrae superioris complex. The tumor was dis...περισσότερα »
Long-Term Outcome Data in Patients following One Year’s Use of a Fully Implantable Active Middle Ear Implant
This study examined the safety and efficacy of a fully implantable active middle ear (AMEI) system. Outcome measures assessed AMEI performance compared with an optimally fitted conventional hearing aid (CHA). Fifty adults with stable, symmetric moderate-to-severe sensorineural hearing loss were implanted at 9 ambulatory settings. Consonant-Nucleus-Consonant (CNC) words, Bamford-Kowel-Bench Speech in Noise test (BKB-SIN), Abbreviated… Continue reading Long-Term Outcome Data in Patients following One Year’s Use of a Fully Implantable Active Middle Ear Implant
Finnes det barn i Norge uten rett på medisinsk behandling?
Yrkesetikk mot jus. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/234mK1l via IFTTT
Precision treatment for NF1 steps closer with mutation clues
A new study suggests the particular symptoms likely to arise in a person with neurofibromatosis type 1 may be determined by the particular mutation they have in their NF1 gene. from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1MDwziw via IFTTT
Fractional Flow Assessment for the Evaluation of Intracranial Atherosclerosis: A Feasibility Study
Purpose: Current studies on endovascular intervention for intracranial atherosclerosis select patients based on luminal stenosis. Coronary studies demonstrated that fractional flow measurements assess ischemia better than anatomical stenosis and can guide patient selection for intervention. We similarly postulated that fractional flow can be used to assess ischemic stroke risk. Methods: This was a feasibility study… Continue reading Fractional Flow Assessment for the Evaluation of Intracranial Atherosclerosis: A Feasibility Study
Management of Severe and Complex Hypopharyngeal and/or Laryngotracheal Stenoses by Various Open Surgical Procedures: A Retrospective Study of Seventeen Patients
Objective: To systematically study various surgical approaches for treating complex hypopharyngeal and/or laryngotracheal stenoses at a variety of sites and levels. Patients and Methods: We retrospectively analyzed the treatment of 17 patients with severe and complex hypopharyngeal and/or laryngotracheal stenosis at various sites and levels of severity. All of the 17 patients initially had a… Continue reading Management of Severe and Complex Hypopharyngeal and/or Laryngotracheal Stenoses by Various Open Surgical Procedures: A Retrospective Study of Seventeen Patients
New compounds may aid in development of targeted therapies for a rare paediatric cancer
Two recently discovered compounds have shown promise in preclinical studies for treating Ewing sarcoma, a rare cancer that predominantly affects children and adolescents. Both compounds suppress the activity of EWS-FLI1, which belongs to a class of… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UusyzG via IFTTT
Study confirms link between diabetes drug and increased risk of bladder cancer
The diabetes drug pioglitazone is associated with an increased risk of bladder cancer, finds a study published by The BMJ. The findings suggest that the risk increases with increasing duration of use and dose. No increased risk was seen for a similar… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RzBaiJ via IFTTT
Stable Voice Clusters Identified When Using the Maximum versus Minimum Intensity Curve in the Phonetogram
Objective: To examine whether the minimum as well as the maximum voice intensity (i.e. sound pressure level, SPL) curves of a voice range profile (VRP) are required when discovering different voice groups based on a clustering analysis. In this approach, no a priori labeling of voice types is used. Patients and Methods: VRPs of 194… Continue reading Stable Voice Clusters Identified When Using the Maximum versus Minimum Intensity Curve in the Phonetogram
“Infectious Enthusiasm!” “Larger than Life!” “That Laugh!” “That Smile!” In Loving Memory of Richard G.H. (Dick) Cotton
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
We present a collection of reminiscences and tributes from several of Dick Cotton’s colleagues and fellow Human Mutation editorial board members. Dick would have not even imagined people bothering with written accolades about himself, since he was all about others – and bringing others together toward a common humanitarian goal. That said, Dick would have […]
Long-Term Outcome Data in Patients following One Year’s Use of a Fully Implantable Active Middle Ear Implant
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
This study examined the safety and efficacy of a fully implantable active middle ear (AMEI) system. Outcome measures assessed AMEI performance compared with an optimally fitted conventional hearing aid (CHA). Fifty adults with stable, symmetric moderate-to-severe sensorineural hearing loss were implanted at 9 ambulatory settings. Consonant-Nucleus-Consonant (CNC) words, Bamford-Kowel-Bench Speech in Noise test (BKB-SIN), Abbreviated […]
Finnes det barn i Norge uten rett på medisinsk behandling?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
Yrkesetikk mot jus. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/234mK1l via IFTTT
Management of Severe and Complex Hypopharyngeal and/or Laryngotracheal Stenoses by Various Open Surgical Procedures: A Retrospective Study of Seventeen Patients
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
Objective: To systematically study various surgical approaches for treating complex hypopharyngeal and/or laryngotracheal stenoses at a variety of sites and levels. Patients and Methods: We retrospectively analyzed the treatment of 17 patients with severe and complex hypopharyngeal and/or laryngotracheal stenosis at various sites and levels of severity. All of the 17 patients initially had a […]
New compounds may aid in development of targeted therapies for a rare paediatric cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
Two recently discovered compounds have shown promise in preclinical studies for treating Ewing sarcoma, a rare cancer that predominantly affects children and adolescents. Both compounds suppress the activity of EWS-FLI1, which belongs to a class of… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UusyzG via IFTTT
Study confirms link between diabetes drug and increased risk of bladder cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
The diabetes drug pioglitazone is associated with an increased risk of bladder cancer, finds a study published by The BMJ. The findings suggest that the risk increases with increasing duration of use and dose. No increased risk was seen for a similar… from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RzBaiJ via IFTTT
Stable Voice Clusters Identified When Using the Maximum versus Minimum Intensity Curve in the Phonetogram
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 30 δευτερόλεπτα
Objective: To examine whether the minimum as well as the maximum voice intensity (i.e. sound pressure level, SPL) curves of a voice range profile (VRP) are required when discovering different voice groups based on a clustering analysis. In this approach, no a priori labeling of voice types is used. Patients and Methods: VRPs of 194 […]
Pyogenic Myositis
An unusual aetiology of back pain: We present the case of a healthy young man who developed pyogenic myositis, an infection that is rare in the USA. He had no prior medical conditions except for an obsessive-compulsive disorder and skin picking disorder resulting in multiple superficial skin infections. He presented to our hospital with acute back pain. He was found to be septic with fever, tachycardia and elevated white cell counts. Imaging revealed evidence of myositis in the gluteal region. He was treated with antibiotics and fully recovered. It is likely that the skin picking d... περισσότερα »
Three types of osseous dysplasia: periapical cemental dysplasia (PCD), focal cemento-osseous dysplasia (FCD) and florid osseous dysplasia (FOD)
Familial florid osseous dysplasia: a report with review of the literature: There are three types of osseous dysplasia: periapical cemental dysplasia (PCD), focal cemento-osseous dysplasia (FCD) and florid osseous dysplasia (FOD). While PCD is often observed in mandibular anterior teeth, FCD mainly affects mandibular posterior teeth. FOD, on the other hand, commonly involves both jaws. FOD is a type of sclerosing disease that is characterised by intense opaque masses and many areas with different densities. Genetic heritance of FOD is unusual, with only a few reported cases. We desc... περισσότερα »
Sickle Cell Disease, Headache, and Difficulty Speaking
Case 10-2016: A 22-Year-Old Man with Sickle Cell Disease, Headache, and Difficulty Speaking: Presentation of Case. Dr. Todd M. Herrington (Neurology): A 22-year-old right-handed man was admitted to this hospital because of the acute onset of headache and difficulty speaking. The patient had been well until approximately noon on the day of admission, when a dull, diffuse headache developed;…
Detection of Thyroid Transcription Factor 1 and Napsin A Expression in Lung Adenocarcinomas.
Ribonucleic Acid In Situ Hybridization Is a More Sensitive Method Than Immunohistochemistry... Arch Pathol Lab Med. 2016 Apr;140(4):332-340 Authors: Shi J, Liu H, Ma XJ, Chen Z, He MX, Luo Y, Lin F Abstract CONTEXT: -TTF-1 and napsin A immunomarkers have a crucial role in differentiating lung adenocarcinoma from lung squamous cell carcinoma and in identifying a primary lung adenocarcinoma when working on a tumor of unknown origin. OBJECTIVES: -To investigate the diagnostic sensitivity of ribonucleic acid in situ hybridization (RNAscope) in the detection of expression of these bio...περισσότερα »
Ossifying Fibromyxoid Tumor....Atypical Fibroxanthoma
Ossifying Fibromyxoid Tumor: An Update. by Bakiratharajan D, Rekhi B via Archives of pathology and laboratory medicine Arch Pathol Lab Med. 2016 Apr;140(4):371-375 Authors: Bakiratharajan D, Rekhi B Abstract Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain differentiation, initially described by Enzinger and colleagues. Until now, nearly 300 such cases have been reported worldwide. The histogenesis of these tumors remains controversial. These tumors show characteristic imaging findings and exhibit a spectrum of histopathologic features, including classic...περισσότερα »
Dexamethasone Does Not Inhibit Sugammadex Reversal After Rocuronium-Induced Neuromuscular Block.
Dexamethasone Does Not Inhibit Sugammadex Reversal After Rocuronium-Induced Neuromuscular Block.: BACKGROUND: Sugammadex is a relatively new molecule that reverses neuromuscular block induced by rocuronium. The particular structure of sugammadex traps the cyclopentanoperhydrophenanthrene ring of rocuronium in its hydrophobic cavity. Dexamethasone shares the same steroidal structure with rocuronium. Studies in vitro have demonstrated that dexamethasone interacts with sugammadex, reducing its efficacy. In this study, we investigated the clinical relevance of this interaction and its i... περισσότερα »
Predictors of Difficult Intubation with the Bonfils Rigid Fiberscope.
Predictors of Difficult Intubation with the Bonfils Rigid Fiberscope.: BACKGROUND: Endotracheal intubation is commonly performed via direct laryngoscopy (DL). However, in certain patients, DL may be difficult or impossible. The Bonfils Rigid Fiberscope(R) (BRF) is an alternative intubation device, the design of which raises the question of whether factors that predict difficult DL also predict difficult BRF. We undertook this study to determine which demographic, morphologic, and morphometric factors predict difficult intubation with the BRF. METHODS: Four hundred adult patients sch... περισσότερα »
Commercial Pulse Oximeter Sonifications
The Sounds of Desaturation: A Survey of Commercial Pulse Oximeter Sonifications.: BACKGROUND: The pulse oximeter has been a standard of care medical monitor for >25 years. Most manufacturers include a variable-pitch pulse tone in their pulse oximeters. Research has shown that the acoustic properties of variable-pitch tones are not standardized. In this study, we surveyed the properties of pulse tones from 21 pulse oximeters, consisting of 1 to 4 instruments of 11 different models and 8 brands. Our goals were to fully document the sounds over saturation values 0% to 100%, test whethe...περισσότερα »
Asthma in Urban Children
: Epidemiology, Environmental Risk Factors, and the Public Health Domain: AbstractAsthma is the most commonly reported chronic condition of childhood in developed countries, with 6.5 million children affected in the USA. A disparate burden of childhood asthma is seen among socioeconomically disadvantaged youth, often concentrated in urban areas with high poverty rates. Host factors that predispose a child to asthma include atopy, male gender, parental history of asthma, and also race, ethnicity, and genetic and epigenetic susceptibilities. Environmental factors, such as improved hy...περισσότερα »
Paternally transmitted genetic variant effect on asthma plus rhinitis : DNA methylation within melatonin receptor 1A (MTNR1A)
mediates paternally transmitted genetic variant effect on asthma plus rhinitis via Allergy and Clinical Immunology Publication date: Available online 30 March 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Chloé Sarnowski, Catherine Laprise, Giovanni Malerba, Miriam F. Moffatt, Marie-Hélène Dizier, Andréanne Morin, Quentin B. Vincent, Klaus Rohde, Jorge Esparza-Gordillo, Patricia Margaritte-Jeannin, Liming Liang, Young-Ae Lee, Jean Bousquet, Valérie Siroux, Pier Franco Pignatti, William O. Cookson, Mark Lathrop, Tomi Pastinen, Florence Demenais, Emmanuelle Bouzig...περισσότερα »
Cell attachment and proliferation of osteoblast-like MG63 cells on silk fibroin membrane for guided bone regeneration
Cell attachment and proliferation of osteoblast-like MG63 cells on silk fibroin membrane for guided bone regeneration: Abstract BackgroundThe aim of this study is to verify the feasibility of using silk fibroin (SF) as a potential membrane for guided bone regeneration (GBR). MethodsVarious cellular responses (i.e., cell attachment, viability, and proliferation) of osteoblast-like MG63 cells cultured on an SF membrane were quantified. After culturing on an SF membrane for 1, 5, and 7 days, the attachment and surface morphology of MG63 cells were examined by optical and scanning ... περισσότερα »
Craniofacial development and hypodontia in patients with Down syndrome
The relationship between craniofacial development and hypodontia in patients with Down syndrome: Background/objective: Hypodontia is often seen in people with Down syndrome (DS). In the normal population, persons with hypodontia have a shorter cranial base and a hypoplastic maxilla, leading to a skeletal Class III tendency and a reduced face height. The purpose of this study was to examine craniofacial morphology in patients with DS at different ages and the influence of hypodontia on their craniofacial morphology. Materials and methods: A comparative cross-sectional study was cond...περισσότερα »
Rating nasolabial appearance on three-dimensional images in cleft lip and palate
: a comparison with standard photographs: Background/Objective: Judgement of nasolabial aesthetics in cleft lip and palate (CLP) is a vital component of assessment of treatment outcome. It is usually performed based on two-dimensional (2D) facial photographs. An increasing use of three-dimensional (3D) imaging warrants an assessment if 3D images can substitute 2D photographs during aesthetic evaluation. The aim of this study was to compare reliability of rating nasolabial appearance on 3D images and standard 2D photographs in prepubertal children. Methods: Forty subjects (age: 8.8–...περισσότερα »
Anterior crossbite
A cost minimization analysis of early correction of anterior crossbite--a randomized controlled trial: Objective: Economic evaluations provide an important basis for allocation of resources and health services planning. The aim of this study was to evaluate and compare the costs of correcting anterior crossbite with functional shift, using fixed or removable appliances (FA or RA) and to relate the costs to the effects, using cost-minimization analysis. Design, Setting, and Participants: Sixty-two patients with anterior crossbite and functional shift were randomized in blocks of 10.... περισσότερα »
Stability of Class II fixed functional appliance therapy
a systematic review and meta-analysis: Objectives: To systematically search for scientific evidence concerning the stability of treatment (Tx) results achieved by means of Class II fixed functional appliance therapy and to assess possible differences between appliances. Search Methods: An electronic search of databases and orthodontic journals was carried out (until December 2013), with supplemental hand searching. In addition to the *names* of all identified appliances, the term *fixed functional* was used in combination with each of the following search terms: *long-term, post-Tx... περισσότερα »
Fixed functional appliances in patients with Class II malocclusion
: a systematic review and meta-analysis: Objective: To assess the treatment effects of fixed functional appliances (FFAs) in treated versus untreated Class II patients by means of lateral cephalometric radiographs. Search methods: Unrestricted electronic search of 18 databases and additional manual searches up to October 2014. Selection criteria: Prospective randomized and non-randomized controlled trials reporting on cephalometric angular measurements of Class II patients treated with FFAs and their matched untreated controls. Data collection and analysis: Skeletal, dental, and... περισσότερα »
The anterior component of occlusal force revisited
: direct measurement and theoretical considerations: Background: The anterior component of occlusal force (ACF), considered to result from the mesial inclination of teeth relative to the occlusal plane, has been estimated by indirectly measuring contact point tightness (CPT) through interproximal insertion of metal strips. ACF has been observed concurrently with a posterior component, whose theoretical origin is difficult to explain. Objectives: Evaluate ACF by measuring CPT directly, and integrate current data to propose a theoretical basis for ACF. Materials and methods: The sa...περισσότερα »
Bonded versus banded rapid palatal expander followed by facial mask therapy
: analysis on digital dental casts: Objectives: To compare the dental effects produced by a bonded versus a banded expander combined with facial mask (FM) in patients with Class III malocclusion by means of digital dental casts. Materials and methods: Two groups of patients with Class III malocclusion and maxillary transverse deficiency in the deciduous or early mixed dentition were selected. The first group consisted of 25 subjects (12 females; 13 males) with a mean age of 7.4 years (SD 1.2 years) treated with a bonded expander and FM. The second group consisted of 25 subjects (13...περισσότερα »
The Cementocyte
An Osteocyte Relative?: Cementum is a mineralized tissue covering the tooth root that functions in tooth attachment and posteruptive adjustment of tooth position. During formation of the apically located cellular cementum, some cementoblasts become embedded in the cementoid matrix and become cementocytes. As apparently terminally differentiated cells embedded in a mineralized extracellular matrix, cementocytes are part of a select group of specialized cells, also including osteocytes, hypertrophic chondrocytes, and odontoblasts. The differentiation and potential function(s) of cem... περισσότερα »
Community-level risk of oral diseases for planning public dental services
Developing a model to assess community-level risk of oral diseases for planning public dental services in Australia: Abstract BackgroundPoor oral health is a chronic condition that can be extremely costly to manage. In Australia, publicly funded dental services are provided to community members deemed to be eligible—those who are socio-economically disadvantaged or determined to be at higher risk of dental disease. Historically public dental services have nominally been allocated based on the size of the eligible population in a geographic area. This approach has been largely inad...περισσότερα »
Tonsillar microbiota in children with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) syndrome.
Tonsillar microbiota in children with PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and adenitis) syndrome.: Eur J Clin Microbiol Infect Dis. 2016 Mar 30; Authors: Tejesvi MV, Uhari M, Tapiainen T, Pirttilä AM, Suokas M, Lantto U, Koivunen P, Renko M Abstract Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a childhood febrile syndrome of unknown origin that is often cured with tonsillectomy. We aimed to compare the bacterial microbiota of the tonsils removed from PFAPA patients with those of controls. We used next-generation sequencing technolo... περισσότερα »
Hypopharyngeal and/or Laryngotracheal Stenoses
Management of Severe and Complex Hypopharyngeal and/or Laryngotracheal Stenoses by Various Open Surgical Procedures: A Retrospective Study of Seventeen Patients: *Objective:* To systematically study various surgical approaches for treating complex hypopharyngeal and/or laryngotracheal stenoses at a variety of sites and levels. *Patients and Methods:* We retrospectively analyzed the treatment of 17 patients with severe and complex hypopharyngeal and/or laryngotracheal stenosis at various sites and levels of severity. All of the 17 patients initially had a tracheostomy. Thirteen had f... περισσότερα »
Conditioned Play Audiometry
* It Should Be All Fun and Games: * Author Information *Dr. Wolfe, left, is the director of audiology at Hearts for Hearing and an adjunct assistant professor at the University of Oklahoma Health Sciences Center and Salus University. Ms. Smith, center, is a founder and the executive director of Hearts for Hearing in Oklahoma City, where Dr. Neumann, right, is a clinical audiologist and deaf education consultant at Hearts for Hearing in Oklahoma City.* *As hearing health professionals, we are often confined to the clinic all day, every day of the week, and can find ourselves longin... περισσότερα »
Cystic Fibrosis : Hearing loss
*Hearing Loss Risk Factors for Cystic Fibrosis Patients: * Author Information *Dr. Steyger is a professor Otolaryngology – Head & Neck Surgery at the Oregon Health & Science University. Dr. Garinis is a research associate in the Oregon Hearing Research Center (OHRC).* *Cystic fibrosis (CF) is a life-threatening autosomal recessive genetic disorder characterized by poor cellular ion regulation and water balance leading to poor mucous transport from the lungs and other organs. CF-related illnesses are often caused by bacterial lung infections, such as Pseudomonas aeruginosa, or methi...περισσότερα »
Asymmetric Hearing Loss
*Symptom: Asymmetric Hearing Loss: * *[image: image]* Author Information *Dr. Djalilian is director of neurotology and skull base surgery and associate professor of otolaryngology and biomedical engineering at the University of California, Irvine.* *A 23-year-old man comes in for a hearing evaluation. He states that he plans to enlist with the Coast Guard and wants to check his hearing before he goes in for his physical. He feels that the hearing in his left ear may be slightly worse than that in the right ear. He denies any recent history of ear infection. He had ear surgery for ... περισσότερα »
Outcomes and lessons learned from a randomized controlled trial to reduce healthcare utilization during the first year after spinal cord injury rehabilitation: Telephone counseling vs. Usual Care
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 46 δευτερόλεπτα
Publication date: Available online 30 March 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Jessica L. Mackelprang, Jeanne M. Hoffman, Chris Garbaccio, Charles H. Bombardier ObjectiveTo describe the outcomes and lessons learned from a trial of telephone counseling to reduce medical complications and healthcare utilization, and to improve psychosocial outcomes during the first year after spinal cord injury (SCI).DesignSingle-site, single blind, randomized (1:1) controlled trial comparing usual care plus telephone counseling (TC) to usual care (UC). Outcomes ...περισσότερα »
Molecular imaging of movement disorders.
*Molecular imaging of movement disorders.* World J Radiol. 2016 Mar 28;8(3):226-239 Authors: Lizarraga KJ, Gorgulho A, Chen W, De Salles AA Abstract Positron emission tomography measures the activity of radioactively labeled compounds which distribute and accumulate in central nervous system regions in proportion to their metabolic rate or blood flow. Specific circuits such as the dopaminergic nigrostriatal projection can be studied with ligands that bind to the pre-synaptic dopamine transporter or post-synaptic dopamine receptors (D1 and D2). Single photon emission computerized ...περισσότερα »
Subclinical hyperthyroidism: First do no harm.
*Subclinical hyperthyroidism: First do no harm.* Clin Endocrinol (Oxf). 2016 Mar 29; Authors: Mitchell AL, Pearce SH Abstract The consequences of overt thyrotoxicosis, including an increased risk of cardiac dysrhythmias, cardiovascular disease and osteoporosis, are well recognised. It is the awareness of these adverse clinical outcomes in the longer term, coupled with the need to manage the unpleasant symptoms of thyrotoxicosis in the short term, that prompts intervention to render the patient euthyroid, either with antithyroid drugs, radioactive iodine or by surgery. However, th... περισσότερα »
Preserving Parathyroid Gland Vasculature to Reduce Post-thyroidectomy Hypocalcemia.
*Preserving Parathyroid Gland Vasculature to Reduce Post-thyroidectomy Hypocalcemia.* World J Surg. 2016 Mar 30; Authors: Park I, Rhu J, Woo JW, Choi JH, Kim JS, Kim JH Abstract BACKGROUND: The failure to preserve parathyroid function in patients who have undergone total thyroidectomy is of major concern, because hypocalcemia is difficult to prevent and remains a common postoperative complication. Here, we describe procedures designed to preserve the vasculature supplying the parathyroid glands and examine both recent outcomes and retrospective reports of results obtained prior t... περισσότερα »
Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII+PTEN-glioblastoma in vivo.
*Combination of an anti-EGFRvIII antibody CH12 with Rapamycin synergistically inhibits the growth of EGFRvIII+PTEN-glioblastoma in vivo.* Oncotarget. 2016 Mar 26; Authors: Xu W, Bi Y, Kong J, Zhang J, Wang B, Li K, Tian M, Pan X, Shi B, Gu J, Jiang H, Kong X, Li Z Abstract There are still unmet medical needs for the treatment of glioblastoma (GBM), the most frequent and aggressive brain tumor worldwide. EGFRvIII, overexpressed in approximately 30% of GBM, has been regarded as a potential therapeutic target. In this study, we demonstrated that CH12, an anti-EGFRvIII monoclonal ant... περισσότερα »
Neuraminidase-1: A novel therapeutic target in multistage tumorigenesis.
*Neuraminidase-1: A novel therapeutic target in multistage tumorigenesis.* Oncotarget. 2016 Mar 27; Authors: Haxho F, Neufeld RJ, Szewczuk MR Abstract Several of the growth factors and their receptor tyrosine kinases (RTK) such as epidermal growth factor (EGF), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), nerve growth factor (NGF) and insulin are promising candidate targets for cancer therapy. Indeed, tyrosine kinase inhibitors (TKI) have been developed to target these growth factors and their receptors, and have...περισσότερα »
Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1.
*Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1.* Oncotarget. 2016 Mar 25; Authors: Chen JY, Li CF, Chu PY, Lai YS, Chen CH, Jiang SS, Hou MF, Hung WC Abstract Alterations of histone methylation dynamically regulated by methyltransferases and demethylases are frequently found in human cancers. Here, we showed that expression of lysine demethylase 2A (KDM2A) is markedly increased in human breast cancer and its overexpression is associated with tumor progression and poor prognosis. Knockdown of KDM2A in breast cancer cells reduced ... περισσότερα »
R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells.
*R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells.* J Vasc Res. 2016 Mar 31;52(5):347-359 Authors: Sawada J, Li F, Komatsu M Abstract R-Ras is a Ras family small GTPase that is highly expressed in mature functional blood vessels in normal tissues. It inhibits pathological angiogenesis and promotes vessel maturation and stabilization. Previous studies suggest that R-Ras affects cellular signaling in endothelial cells, pericytes and smooth-muscle cells to regulate vessel formation and remodeling in adult tissues. R-Ras suppresses VEGF-in...περισσότερα »
DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Publication date: Available online 30 March 2016 Source:Journal of Allergy and Clinical Immunology Author(s): Chloé Sarnowski, Catherine Laprise, Giovanni Malerba, Miriam F. Moffatt, Marie-Hélène Dizier, Andréanne Morin, Quentin B. Vincent, Klaus Rohde, Jorge Esparza-Gordillo, Patricia Margaritte-Jeannin, Liming Liang, Young-Ae Lee, Jean Bousquet, Valérie Siroux, Pier Franco Pignatti, William O. Cookson, Mark Lathrop, Tomi Pastinen, Florence […]
Long-Term Outcome Data in Patients following One Year’s Use of a Fully Implantable Active Middle Ear Implant
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
This study examined the safety and efficacy of a fully implantable active middle ear (AMEI) system. Outcome measures assessed AMEI performance compared with an optimally fitted conventional hearing aid (CHA). Fifty adults with stable, symmetric moderate-to-severe sensorineural hearing loss were implanted at 9 ambulatory settings. Consonant-Nucleus-Consonant (CNC) words, Bamford-Kowel-Bench Speech in Noise test (BKB-SIN), Abbreviated […]
Precision treatment for NF1 steps closer with mutation clues
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
A new study suggests the particular symptoms likely to arise in a person with neurofibromatosis type 1 may be determined by the particular mutation they have in their NF1 gene. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1MDwziw via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Fractional Flow Assessment for the Evaluation of Intracranial Atherosclerosis: A Feasibility Study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Purpose: Current studies on endovascular intervention for intracranial atherosclerosis select patients based on luminal stenosis. Coronary studies demonstrated that fractional flow measurements assess ischemia better than anatomical stenosis and can guide patient selection for intervention. We similarly postulated that fractional flow can be used to assess ischemic stroke risk. Methods: This was a feasibility study […]
Management of Severe and Complex Hypopharyngeal and/or Laryngotracheal Stenoses by Various Open Surgical Procedures: A Retrospective Study of Seventeen Patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Objective: To systematically study various surgical approaches for treating complex hypopharyngeal and/or laryngotracheal stenoses at a variety of sites and levels. Patients and Methods: We retrospectively analyzed the treatment of 17 patients with severe and complex hypopharyngeal and/or laryngotracheal stenosis at various sites and levels of severity. All of the 17 patients initially had a […]
Developing a model to assess community-level risk of oral diseases for planning public dental services in Australia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Abstract Background Poor oral health is a chronic condition that can be extremely costly to manage. In Australia, publicly funded dental services are provided to community members deemed to be eligible—those who are socio-economically disadvantaged or determined to be at higher risk of dental disease. Historically public dental services have nominally been allocated based on […]
Studies of Influenza A/H1N1 A/Tomsk/13/2010 Virus Topology during Development of Infectious Process in Mammals
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Influenza A/H1N1 A/Tomsk/13/2010 virus registered in Siberia in 2010 proved to be an extremely pathogenic strain. Dynamic study of the topology of this influenza virus strain in the lungs, liver, kidneys, lymph nodes, and great vessels of infected mice was carried out. Influenza A virus was detected by immunohistochemical methods in cells of different histogenesis […]
64Cu-ATSM therapy targets regions with activated DNA repair and enrichment of CD133+ cells in an HT-29 tumor model: Sensitization with a nucleic acid antimetabolite
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Publication date: 28 June 2016 Source:Cancer Letters, Volume 376, Issue 1 Author(s): Yukie Yoshii, Takako Furukawa, Hiroki Matsumoto, Mitsuyoshi Yoshimoto, Yasushi Kiyono, Ming-Rong Zhang, Yasuhisa Fujibayashi, Tsuneo Saga 64Cu-diacetyl-bis (N4-methylthiosemicarbazone) (64Cu-ATSM) is a potential theranostic agent targeting the over-reduced state under hypoxia within tumors. Recent clinical Cu-ATSM positron emission tomography studies have revealed a correlation […]
Gankyrin activates mTORC1 signaling by accelerating TSC2 degradation in colorectal cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Publication date: 28 June 2016 Source:Cancer Letters, Volume 376, Issue 1 Author(s): Xiaoyu Qin, Xinxin Wang, Feng Liu, Laura E. Morris, Xiaowen Wang, Bin Jiang, Yanjie Zhang Gankyrin is overexpressed in some malignancies. However its roles in colorectal carcinogenesis and underlying mechanisms remain largely unexplored. Here we report that gankyrin promotes the initiation and development […]
Differentiation therapy of hepatocellular carcinoma by inhibiting the activity of AKT/GSK-3β/β-catenin axis and TGF-β induced EMT with sophocarpine
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 48 δευτερόλεπτα
Publication date: 28 June 2016 Source:Cancer Letters, Volume 376, Issue 1 Author(s): Ping-Ping Zhang, Pei-Qin Wang, Chun-Ping Qiao, Qing Zhang, Jun-Ping Zhang, Fei Chen, Xin Zhang, Wei-Fen Xie, Zong-Li Yuan, Zhao-Shen Li, Yue-Xiang Chen Hepatocellular carcinoma progression is thought to be driven by cancer stem cells (CSCs). No clinical trial has, as yet, shown convincing […]
Plantar Pressure Measurements and Running-related Injury
: A Systematic Review of Methods and Possible Associations via Gait & Posture Publication date: Available online 30 March 2016 *Source:*Gait & Posture Author(s): Robert Mann, Laurent Malisoux, Axel Urhausen, Kenneth Meijer, Daniel Theisen Pressure-sensitive measuring devices have been identified as appropriate tools for measuring an array of parameters during running. It is unclear which biomechanical characteristics relate to running-related injury (RRI) and which data-processing techniques are most promising to detect this relationship. This systematic review aims to identify pertine...περισσότερα »
Multi-Session Balance and Gait Training with Multi-Modal Biofeedback
Benefits of Multi-Session Balance and Gait Training with Multi-Modal Biofeedback in Healthy Older Adults via Gait & Posture Publication date: Available online 30 March 2016 *Source:*Gait & Posture Author(s): Shannon B. Lim, Brian C. Horslen, Justin R. Davis, John H.J. Allum, Mark G. Carpenter Real-time balance-relevant biofeedback from a wearable sensor can improve balance in many patient populations, however, it is unknown if balance training with biofeedback has lasting benefits for healthy older adults once training is completed and biofeedback removed. This study was designed to d... περισσότερα »
Sensors, Vol. 16, Pages 464: SACRB-MAC: A High-Capacity MAC Protocol for Cognitive Radio Sensor Networks in Smart Grid
The Cognitive Radio Sensor Network (CRSN) is considered as a viable solution to enhance various aspects of the electric power grid and to realize a smart grid. However, several challenges for CRSNs are generated due to the harsh wireless environment in a smart grid. As a result, throughput and reliability become critical issues. On the other hand, the spectrum aggregation technique is expected to play an important role in CRSNs in a smart grid. By using spectrum aggregation, the throughput of CRSNs can be improved efficiently, so as to address the unique challenges of CRSNs in a s... περισσότερα »
Photonics, Vol. 3, Pages 15: An Energy-Efficient High-Throughput Mesh-Based Photonic On-Chip Interconnect for Many-Core Systems
Future high-performance embedded and general purpose processors and systems-on-chip are expected to combine hundreds of cores integrated together to satisfy the power and performance requirements of large complex applications. As the number of cores continues to increase, the employment of low-power and high-throughput on-chip interconnect fabrics becomes imperative. In this work, we present a novel mesh-based photonic on-chip interconnect, named PHENIC-II, for future high-performance many-core systems. The novel architecture is based on an energy-efficient non-blocking photonic s... περισσότερα »
Fractional Flow Assessment for the Evaluation of Intracranial Atherosclerosis: A Feasibility Study
*Purpose:* Current studies on endovascular intervention for intracranial atherosclerosis select patients based on luminal stenosis. Coronary studies demonstrated that fractional flow measurements assess ischemia better than anatomical stenosis and can guide patient selection for intervention. We similarly postulated that fractional flow can be used to assess ischemic stroke risk. *Methods:* This was a feasibility study to assess the technical use and safety of applying a pressure guidewire to measure fractional flow across intracranial stenoses. Twenty patients with severe intracran... περισσότερα »
Fully Implantable Active Middle Ear Implant
Long-Term Outcome Data in Patients following One Year's Use of a Fully Implantable Active Middle Ear Implant: This study examined the safety and efficacy of a fully implantable active middle ear (AMEI) system. Outcome measures assessed AMEI performance compared with an optimally fitted conventional hearing aid (CHA). Fifty adults with stable, symmetric moderate-to-severe sensorineural hearing loss were implanted at 9 ambulatory settings. Consonant-Nucleus-Consonant (CNC) words, Bamford-Kowel-Bench Speech in Noise test (BKB-SIN), Abbreviated Profile of Hearing Aid Benefit (APHAB), an... περισσότερα »
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
*Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. STUDY DESIGN: Prospective clinical study. SETTING: Multicenter, tertiary care hospitals. SUBJECTS AND METHODS: The age range of the 28 participants was 22 to 47 yea... περισσότερα »
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
*Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. STUDY DESIGN: Prospective clinical study. SETTING: Multicenter, tertiary care hospitals. SUBJECTS AND METHODS: The age range of the 28 participants was 22 to 47 yea... περισσότερα »
Long-Term Outcome Data in Patients following One Year's Use of a Fully Implantable Active Middle Ear Implant
This study examined the safety and efficacy of a fully implantable active middle ear (AMEI) system. Outcome measures assessed AMEI performance compared with an optimally fitted conventional hearing aid (CHA). Fifty adults with stable, symmetric moderate-to-severe sensorineural hearing loss were implanted at 9 ambulatory settings. Consonant-Nucleus-Consonant (CNC) words, Bamford-Kowel-Bench Speech in Noise test (BKB-SIN), Abbreviated Profile of Hearing Aid Benefit (APHAB), and unaided hearing thresholds in the implanted ear were compared to baseline measures obtained using a person... περισσότερα »
Management of Severe and Complex Hypopharyngeal and/or Laryngotracheal Stenoses by Various Open Surgical Procedures: A Retrospective Study of Seventeen Patients
*Objective:* To systematically study various surgical approaches for treating complex hypopharyngeal and/or laryngotracheal stenoses at a variety of sites and levels. *Patients and Methods:* We retrospectively analyzed the treatment of 17 patients with severe and complex hypopharyngeal and/or laryngotracheal stenosis at various sites and levels of severity. All of the 17 patients initially had a tracheostomy. Thirteen had failed the previous laser lysis and/or dilation treatment. Given the high severity and complexity of stenosis, all of these patients were treated by open surgical ...περισσότερα »
Increasing aphasia treatment intensity in an acute inpatient rehabilitation program: A feasibility study.
*Increasing aphasia treatment intensity in an acute inpatient rehabilitation program: A feasibility study.* Aphasiology. 2016 May 1;30(5):542-565 Authors: Carpenter J, Cherney LR Abstract BACKGROUND: Intensity of therapy is a critical factor influencing outcomes in aphasia. However, there are many barriers to increasing treatment intensity for those with acute/subacute aphasia including the demands of the inpatient medical facilities and the endurance of the participants. Nevertheless, with some modifications to its original procedures, evidence suggests that Constraint Induced L...περισσότερα »
Asking 'What about' questions in chronic illness self-management meetings.
*Asking 'What about' questions in chronic illness self-management meetings.* Patient Educ Couns. 2016 Mar 16; Authors: Fasulo A, Zinken J, Zinken K Abstract OBJECTIVES: This study investigates 'What about' questions asked by patients in the course of diabetes self-management groups led by nurses, and explores their functions in these empowerment-informed settings. METHODS: Conversation Analysis of 24 video-recorded sessions of a Start Insulin Group Programme for patients with type 2 diabetes, in a diabetes centre in the South of England. The groups included 2-7 patients and were l...περισσότερα »
Comparison of Newborn Hearing Screening in Well-Baby Nursery and NICU: A Study Applied to Reduce Referral Rate in NICU.
Related Articles *Comparison of Newborn Hearing Screening in Well-Baby Nursery and NICU: A Study Applied to Reduce Referral Rate in NICU.* PLoS One. 2016;11(3):e0152028 Authors: Li PC, Chen WI, Huang CM, Liu CJ, Chang HW, Lin HC Abstract OBJECTIVES: To determine whether newborn hearing screening in a well-baby nursery (WBN) and neonatal intensive care unit (NICU) nursery: 1) meet three targeted, screening, referral, and diagnostic follow-up rates; 2) compare the average age of diagnosis for infants admitted to the WIN and NICU; and 3) determine prevalence of hearing loss in neona...περισσότερα »
Treatment for dysphagia (swallowing difficulties) in hereditary ataxia.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Treatment for dysphagia (swallowing difficulties) in hereditary ataxia.* Cochrane Database Syst Rev. 2015;11:CD010169 Authors: Vogel AP, Keage MJ, Johansson K, Schalling E Abstract BACKGROUND: Hereditary ataxias are a heterogeneous group of disorders resulting in progressive inco-ordination. Swallowing impairment, also known as dysphagia, is a common and potentially life threatening sequel of disease progression. The incidence and nature of dysphagia in these conditions is largely unknown. The loss of an effective... περισσότερα »
Development and validation of Australian aphasia rehabilitation best practice statements using the RAND/UCLA appropriateness method.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Development and validation of Australian aphasia rehabilitation best practice statements using the RAND/UCLA appropriateness method.* BMJ Open. 2015;5(7):e007641 Authors: Power E, Thomas E, Worrall L, Rose M, Togher L, Nickels L, Hersh D, Godecke E, O'Halloran R, Lamont S, O'Connor C, Clarke K Abstract OBJECTIVES: To develop and validate a national set of best practice statements for use in post-stroke aphasia rehabilitation. DESIGN: Literature review and statement validation ... περισσότερα »
The Pulmonary Pathology Society's Future: Busy and Bright.
*The Pulmonary Pathology Society's Future: Busy and Bright.* Arch Pathol Lab Med. 2016 Apr;140(4):302 Authors: Allen TC PMID: 27028390 [PubMed - as supplied by publisher] from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1TksTUm via IFTTT
Pathology Residents Are Not "Trainees".
*Pathology Residents Are Not "Trainees".* Arch Pathol Lab Med. 2016 Apr;140(4):301 Authors: Geller SA PMID: 27028389 [PubMed - as supplied by publisher] from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1RMR34u via IFTTT
Pathology Reports: A Second Look.
*Pathology Reports: A Second Look.* Arch Pathol Lab Med. 2016 Apr;140(4):300 Authors: Novis DA PMID: 27028388 [PubMed - as supplied by publisher] from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1TksTE6 via IFTTT
[Underlying Mechanisms and Management of Refractory Gastroesophageal Reflux Disease].
Related Articles *[Underlying Mechanisms and Management of Refractory Gastroesophageal Reflux Disease].* Korean J Gastroenterol. 2015 Aug;66(2):70-4 Authors: Lee KJ Abstract The prevalence of gastroesophageal reflux disease (GERD) in South Korea has increased over the past 10 years. Patients with erosive reflux disease (ERD) shows better response to proton pump inhibitors (PPIs) than those with non-erosive reflux disease (NERD). NERD is a heterogeneous condition, showing pathological gastroesophageal reflux or esophageal hypersensitivity to reflux contents. NERD patients with pat...περισσότερα »
Living with oropharyngeal dysphagia: effects of bolus modification on health-related quality of life--a systematic review.
[image: http:--production.springer.de-OnlineReso] Related Articles *Living with oropharyngeal dysphagia: effects of bolus modification on health-related quality of life--a systematic review.* Qual Life Res. 2015 Oct;24(10):2447-56 Authors: Swan K, Speyer R, Heijnen BJ, Wagg B, Cordier R Abstract PURPOSE: Difficulty swallowing, oropharyngeal dysphagia, is widespread among many patient populations (such as stroke and cancer groups) and aged community-dwelling individuals. It is commonly managed with bolus modification: altering food (usually cutting, mashing or puréeing) or fluids (... περισσότερα »
The Pulmonary Pathology Society's Future: Busy and Bright.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
*The Pulmonary Pathology Society's Future: Busy and Bright.* Arch Pathol Lab Med. 2016 Apr;140(4):302 Authors: Allen TC PMID: 27028390 [PubMed - as supplied by publisher] from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1TksTUm via IFTTT
Pathology Residents Are Not "Trainees".
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
*Pathology Residents Are Not "Trainees".* Arch Pathol Lab Med. 2016 Apr;140(4):301 Authors: Geller SA PMID: 27028389 [PubMed - as supplied by publisher] from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1RMR34u via IFTTT
Pathology Reports: A Second Look.
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 57 δευτερόλεπτα
*Pathology Reports: A Second Look.* Arch Pathol Lab Med. 2016 Apr;140(4):300 Authors: Novis DA PMID: 27028388 [PubMed - as supplied by publisher] from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1TksTE6 via IFTTT
Ribonucleic Acid In Situ Hybridization Is a More Sensitive Method Than Immunohistochemistry in Detection of Thyroid Transcription Factor 1 and Napsin A Expression in Lung Adenocarcinomas.
*Ribonucleic Acid In Situ Hybridization Is a More Sensitive Method Than Immunohistochemistry in Detection of Thyroid Transcription Factor 1 and Napsin A Expression in Lung Adenocarcinomas.* Arch Pathol Lab Med. 2016 Apr;140(4):332-340 Authors: Shi J, Liu H, Ma XJ, Chen Z, He MX, Luo Y, Lin F Abstract CONTEXT: -TTF-1 and napsin A immunomarkers have a crucial role in differentiating lung adenocarcinoma from lung squamous cell carcinoma and in identifying a primary lung adenocarcinoma when working on a tumor of unknown origin. OBJECTIVES: -To investigate the diagnostic sensitivity of...περισσότερα »
Preserving Parathyroid Gland Vasculature to Reduce Post-thyroidectomy Hypocalcemia.
*Preserving Parathyroid Gland Vasculature to Reduce Post-thyroidectomy Hypocalcemia.* World J Surg. 2016 Mar 30; Authors: Park I, Rhu J, Woo JW, Choi JH, Kim JS, Kim JH Abstract BACKGROUND: The failure to preserve parathyroid function in patients who have undergone total thyroidectomy is of major concern, because hypocalcemia is difficult to prevent and remains a common postoperative complication. Here, we describe procedures designed to preserve the vasculature supplying the parathyroid glands and examine both recent outcomes and retrospective reports of results obtained prior t... περισσότερα »
Immunotherapy for Non-Small Cell Lung Cancer - Finally a Hint of Hope.
*Immunotherapy for Non-Small Cell Lung Cancer - Finally a Hint of Hope.* Rev Recent Clin Trials. 2016 Mar 30; Authors: Recondo G, Recondo G, Galanternik F, Greco M, de la Vega M, Cantón ED, Valsecchi ME Abstract Lung cancer is a major public health problem worldwide and the leading cause of cancerrelated mortality in developed countries. Significant advances have been made especially with the discovery of targeted agents. However, only a small proportion of patients carry activating mutations; until recently conventional chemotherapy and angiogenesis inhibitors were the preferred...περισσότερα »
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs.
*Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs.* J Enzyme Inhib Med Chem. 2016 Mar 30;:1-7 Authors: Jabłońska-Trypuć A, Matejczyk M, Rosochacki S Abstract The main group of enzymes responsible for the collagen and other protein degradation in extracellular matrix (ECM) are matrix metalloproteinases (MMPs). Collagen is the main structural component of connective tissue and its degradation is a very important process in the development, morphogenesis, tissue remodeling, and repair. Typical stru... περισσότερα »
Clinical Trials of Antiangiogenesis Therapy in Recurrent/Persistent and Metastatic Cervical Cancer.
*Clinical Trials of Antiangiogenesis Therapy in Recurrent/Persistent and Metastatic Cervical Cancer.* Oncologist. 2016 Mar 29; Authors: Alldredge JK, Tewari KS Abstract BACKGROUND: Treatment options for women with metastatic, persistent, or recurrent cervical cancer are limited and thus the disease portends a poor prognosis. It is critical to understand the pathophysiology of cervical cancer to better delineate therapeutic targets. The development of antiangiogenic therapies and their subsequent analysis in rigorous therapeutic trials have redefined current management strategies ... περισσότερα »
Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial.
*Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial.* Lancet. 2016 Mar 12;387(10023):1066-74 Authors: Ledermann JA, Embleton AC, Raja F, Perren TJ, Jayson GC, Rustin GJ, Kaye SB, Hirte H, Eisenhauer E, Vaughan M, Friedlander M, González-Martín A, Stark D, Clark E, Farrelly L, Swart AM, Cook A, Kaplan RS, Parmar MK, ICON6 collaborators Abstract BACKGROUND: Angiogenesis is a validated clinical target in advanced epithelial ovarian cancer. Cediranib is an oral antiangiogenic vascular endothelial...περισσότερα »
A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer.
Related Articles *A Selenium Containing Inhibitor for the Treatment of Hepatocellular Cancer.* Pharmaceuticals (Basel). 2016;9(2) Authors: Tagaram HR, Desai D, Li G, Liu D, Rountree CB, Gowda K, Berg A, Amin S, Staveley-O'Carroll KF, Kimchi ET Abstract Hepatocellular carcinoma (HCC) is the third most deadly cancer in the world. New treatment strategies are desperately needed due to limited standard therapies. Activation of the Erk, Akt, and STAT3pathways is implicated in the prognosis of HCC. The Se,Se'-1,4-phenylenebis(1,2-ethanediyl) bisisoselenourea (PBISe), is a selenium-co...περισσότερα »
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors.
Related Articles *A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors.* J Vis Exp. 2016;(109) Authors: Stacker SA, Halford MM, Roufail S, Caesar C, Achen MG Abstract The analysis of receptor tyrosine kinases and their interacting ligands involved in vascular biology is often challenging due to the constitutive expression of families of related receptors, a broad range of related ligands and the difficulty of dealing with primary cultures of specialized endothelial cells. Here we describe a bioassay for the detection of ligands to the vascular endothelial ... περισσότερα »
Intravitreal bevacizumab for choroidal metastases: the key to efficacy is simultaneous administration of systemic therapy.
[image: http:--http://ift.tt/1feGv2I] Related Articles *Intravitreal bevacizumab for choroidal metastases: the key to efficacy is simultaneous administration of systemic therapy.* Eye (Lond). 2015 Dec;29(12):1629 Authors: Singh N, Bansal R, Behera D, Gupta A PMID: 26381096 [PubMed - indexed for MEDLINE] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1onUirE via IFTTT
Comment on 'Failure of intravitreal bevacizumab in the treatment of choroidal metastasis'.
[image: http:--http://ift.tt/1feGv2I] Related Articles *Comment on 'Failure of intravitreal bevacizumab in the treatment of choroidal metastasis'.* Eye (Lond). 2015 Dec;29(12):1628-9 Authors: Kourie HR, Antoun J, Kattan J PMID: 26381095 [PubMed - indexed for MEDLINE] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1VUVuAz via IFTTT
Multiple Myeloma--Better Drugs Ask for More Stringent Evaluations.
[image: http:--oncology.jamanetwork.com-images-P] Related Articles *Multiple Myeloma--Better Drugs Ask for More Stringent Evaluations.* JAMA Oncol. 2015 Sep;1(6):754-5 Authors: Sonneveld P PMID: 26181637 [PubMed - indexed for MEDLINE] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1M9mlUu via IFTTT
Biosynthesis of silver nanoparticles using Aeromonas sp. THG-FG1.2 and its antibacterial activity against pathogenic microbes.
*Biosynthesis of silver nanoparticles using Aeromonas sp. THG-FG1.2 and its antibacterial activity against pathogenic microbes.* Artif Cells Nanomed Biotechnol. 2016 Mar 30;:1-7 Authors: Singh H, Du J, Yi TH Abstract Silver nanoparticles were prepared through green route with the aid of Aeromonas sp. THG-FG1.2 as reductant. Visual observation, ultraviolet-visible spectroscopy, transmission electron microscopy, elemental mapping, energy dispersive X-ray spectroscopy, selected area diffraction pattern (SAED), and X-ray diffraction (XRD) were used to characterize the synthesized sil...περισσότερα »
Supra-thyroid alar cartilage approach for the complete resection of laryngeal submucosal tumors and postoperative voice quality.
[image: http:--production.springer.de-OnlineReso] Related Articles *Supra-thyroid alar cartilage approach for the complete resection of laryngeal submucosal tumors and postoperative voice quality.* Eur Arch Otorhinolaryngol. 2015 Oct;272(10):2907-13 Authors: Ueha R, Nito T, Sakamoto T, Fujimaki Y, Yamauchi A, Yamasoba T Abstract Various surgical approaches for the treatment of laryngeal submucosal tumors have been reported. Endoscopic excision is indicated for small lesions, while external approaches are recommended for larger tumors. This report introduces a supra-thyroid alar ca... περισσότερα »
Outcomes and lessons learned from a randomized controlled trial to reduce healthcare utilization during the first year after spinal cord injury rehabilitation: Telephone counseling vs. Usual Care
Publication date: Available online 30 March 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Jessica L. Mackelprang, Jeanne M. Hoffman, Chris Garbaccio, Charles H. Bombardier ObjectiveTo describe the outcomes and lessons learned from a trial of telephone counseling to reduce medical complications and healthcare utilization, and to improve psychosocial outcomes during the first year after spinal cord injury (SCI).DesignSingle-site, single blind, randomized (1:1) controlled trial comparing usual care plus telephone counseling (TC) to usual care (UC). Outcomes ...περισσότερα »
Management Strategies for Skull Base Inverted Papilloma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Management Strategies for Skull Base Inverted Papilloma.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Grayson JW, Khichi SS, Cho DY, Riley KO, Woodworth BA Abstract OBJECTIVE: Inverted papilloma attached to the ventral skull base presents a surgical dilemma because surgical removal of the bony pedicle is critical to decrease risk of recurrence. The objective of this study is to evaluate the effectiveness of endoscopic management of skull base inverted papilloma. STUDY DESIGN: Case series with planned data collection. SETTING: Tertiary medical center. SUBJECTS: Patients with s... περισσότερα »
Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma.
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
*Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Brady JS, Marchiano E, Kam D, Baredes S, Eloy JA, Park RC Abstract OBJECTIVE: Laryngeal cancer most commonly arises from the glottis. Comparable outcomes in survival have been shown in patients with early glottic squamous cell carcinoma treated with either surgery or radiotherapy. STUDY DESIGN AND SETTING: Administrative database study. SUBJECTS AND METHODS: The US National Cancer Institute's SEER database (Surveillance, Epidemiology, and En... περισσότερα »
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
*Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. STUDY DESIGN: Prospective clinical study. SETTING: Multicenter, tertiary care hospitals. SUBJECTS AND METHODS: The age range of the 28 participants was 22 to 47 yea... περισσότερα »
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
*Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. STUDY DESIGN: Prospective clinical study. SETTING: Multicenter, tertiary care hospitals. SUBJECTS AND METHODS: The age range of the 28 participants was 22 to 47 yea... περισσότερα »
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
*Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. STUDY DESIGN: Prospective clinical study. SETTING: Multicenter, tertiary care hospitals. SUBJECTS AND METHODS: The age range of the 28 participants was 22 to 47 yea... περισσότερα »
The Pursuit of Otolaryngology Subspecialty Fellowships.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Pursuit of Otolaryngology Subspecialty Fellowships. Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Wilson MN, Vila PM, Cohen DS, Carter JM, Lawlor CM, Davis KS, Raol NP Abstract OBJECTIVES: To examine otolaryngology resident interest in subspecialty fellowship training and factors affecting interest over time and over the course of residency training STUDY DESIGN: Cross-sectional […]
Human Papillomavirus Vaccination Counseling in Pediatric Training: Are We Discussing Otolaryngology-Related Manifestations?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Human Papillomavirus Vaccination Counseling in Pediatric Training: Are We Discussing Otolaryngology-Related Manifestations? Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Gnagi SH, Gnagi FT, Schraff SA, Hinni ML Abstract OBJECTIVE: Demonstrate the need for increased education regarding otolaryngology-related manifestations of human papillomavirus (HPV). Highlight a need to incorporate otolaryngology-related manifestations of HPV in vaccine counseling. […]
Peritonsillar Abscess: Complication of Acute Tonsillitis or Weber’s Glands Infection?
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Peritonsillar Abscess: Complication of Acute Tonsillitis or Weber’s Glands Infection? Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Klug TE, Rusan M, Fuursted K, Ovesen T Abstract OBJECTIVE: To review the literature concerning the 2 primary hypotheses put forth to explain the pathogenesis of peritonsillar abscess: «the acute tonsillitis hypothesis» (peritonsillar abscess is a complication […]
Laryngeal Preservation in Glottic Cancer: A Comparison of Hospital Charges and Morbidity among Treatment Options.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Laryngeal Preservation in Glottic Cancer: A Comparison of Hospital Charges and Morbidity among Treatment Options. Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Mandelbaum RS, Abemayor E, Mendelsohn AH Abstract OBJECTIVE: When total laryngectomy is not required, organ preservation surgery or radiotherapy is considered the standard of care for primary glottic cancer. These accepted treatment […]
Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Survival Impact of Initial Therapy in Patients with T1-T2 Glottic Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Brady JS, Marchiano E, Kam D, Baredes S, Eloy JA, Park RC Abstract OBJECTIVE: Laryngeal cancer most commonly arises from the glottis. Comparable outcomes in survival have been shown in patients with early glottic […]
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring. Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients […]
Sudden-Onset Sensorineural Hearing Loss after Immunization: A Case-Centered Analysis.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sudden-Onset Sensorineural Hearing Loss after Immunization: A Case-Centered Analysis. Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Baxter R, Lewis N, Bohrer P, Harrington T, Aukes L, Klein NP Abstract OBJECTIVE: Case reports of sudden sensorineural hearing loss (SSHL) following vaccines have led to concerns that vaccines may rarely cause hearing loss. Because of this […]
Prevalence of Voice Disturbances in the Pediatric Craniofacial Patient Population.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Prevalence of Voice Disturbances in the Pediatric Craniofacial Patient Population. Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Fritz MA, Rickert SM Abstract OBJECTIVE: To report on the prevalence of voice disturbances in the pediatric craniofacial population and to prove that the pediatric Voice Handicap Index (pVHI) is a useful questionnaire for this unique population. […]
Survival and Prognosis for Malignant Tumors of Odontogenic Origin.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Survival and Prognosis for Malignant Tumors of Odontogenic Origin. Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Agarwal S, Mark J, Xie C, Ghulam E, Patil Y Abstract OBJECTIVE: Determine survival and factors affecting survival for patients with malignant tumors of odontogenic origin. STUDY DESIGN: Retrospective analysis of the National Cancer Institute’s SEER database (Surveillance, […]
Effects of Memantine on Aminoglycoside-Induced Apoptosis of Spiral Ganglion Cells in Guinea Pigs.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Effects of Memantine on Aminoglycoside-Induced Apoptosis of Spiral Ganglion Cells in Guinea Pigs. Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Kim BY, Bae WY, Hur DY, Kim JR, Koh TK, Lee TH, Park GB Abstract OBJECTIVE: To explore whether memantine, an N-methyl-D-aspartate receptor antagonist, exerts a neuroprotective effect against apoptosis of spiral ganglion cells […]
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
*Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. STUDY DESIGN: Prospective clinical study. SETTING: Multicenter, tertiary care hospitals. SUBJECTS AND METHODS: The age range of the 28 participants was 22 to 47 yea... περισσότερα »
Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.
*Olfactory and Gustatory Functions after Anterior Palatoplasty in Patients with Primary Snoring.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Saglam O, Altundag A, Cayonu M, Salihoglu M, Azizli E, Dursun E, Cetin B Abstract OBJECTIVE: In this study, we investigated the chemical senses (namely, olfaction), the 4 basic tastes, and umami taste in patients who underwent anterior palatoplasty (AP) for primary snoring. STUDY DESIGN: Prospective clinical study. SETTING: Multicenter, tertiary care hospitals. SUBJECTS AND METHODS: The age range of the 28 participants was 22 to 47 yea... περισσότερα »
Stable Voice Clusters Identified When Using the Maximum versus Minimum Intensity Curve in the Phonetogram
*Objective:* To examine whether the minimum as well as the maximum voice intensity (i.e. sound pressure level, SPL) curves of a voice range profile (VRP) are required when discovering different voice groups based on a clustering analysis. In this approach, no a priori labeling of voice types is used. *Patients and Methods:* VRPs of 194 (84 male and 110 female) professional singers were registered and processed. Cluster analysis was performed with the use of features related to (1) both the maximum and minimum SPL curves and (2) the maximum SPL curve only. *Results:* Features related...περισσότερα »
Student life - Make your voice heard.
*Student life - Make your voice heard.* Nurs Stand. 2016 Mar 30;30(31):66 Authors: Day-Calder M Abstract There will be times in life when you find it difficult to stand up for yourself, and so it can be easy to get into the habit of doing anything to avoid confrontation. PMID: 27027203 [PubMed - as supplied by publisher] from Speech via xlomafota13 on Inoreader http://ift.tt/1RMUEzH
Prevalence of Voice Disturbances in the Pediatric Craniofacial Patient Population.
*Prevalence of Voice Disturbances in the Pediatric Craniofacial Patient Population.* Otolaryngol Head Neck Surg. 2016 Mar 29; Authors: Fritz MA, Rickert SM Abstract OBJECTIVE: To report on the prevalence of voice disturbances in the pediatric craniofacial population and to prove that the pediatric Voice Handicap Index (pVHI) is a useful questionnaire for this unique population. STUDY DESIGN: Case series with chart review. SETTING: Tertiary care center. SUBJECTS: Pediatric patients seen by a pediatric otolaryngologist in a craniofacial clinic. METHODS: Consecutive patients (N = 366)... περισσότερα »
Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial.
*Cediranib in patients with relapsed platinum-sensitive ovarian cancer (ICON6): a randomised, double-blind, placebo-controlled phase 3 trial.* Lancet. 2016 Mar 12;387(10023):1066-74 Authors: Ledermann JA, Embleton AC, Raja F, Perren TJ, Jayson GC, Rustin GJ, Kaye SB, Hirte H, Eisenhauer E, Vaughan M, Friedlander M, González-Martín A, Stark D, Clark E, Farrelly L, Swart AM, Cook A, Kaplan RS, Parmar MK, ICON6 collaborators Abstract BACKGROUND: Angiogenesis is a validated clinical target in advanced epithelial ovarian cancer. Cediranib is an oral antiangiogenic vascular endothelial...περισσότερα »
What Is 'Normal?' Evaluating Vital Signs.
*What Is 'Normal?' Evaluating Vital Signs.* Nephrol Nurs J. 2016 Jan-Feb;43(1):49-58; quiz 59 Authors: Van Kuiken D, Huth MM Abstract PROBLEM: Vital sign (VS) assessment and monitoring are often routinely scheduled whether they are needed or not. This practice led pediatric nurse leaders to voice concerns about the frequenty of VS at a National Summit for Pediatric and Adolescent Evidence-Based Practice. A search of databases yielded no direct evidence regarding frequency. However, we determined that before this question could be adequately addressed, we first needed answers to t...περισσότερα »
Increasing aphasia treatment intensity in an acute inpatient rehabilitation program: A feasibility study.
*Increasing aphasia treatment intensity in an acute inpatient rehabilitation program: A feasibility study.* Aphasiology. 2016 May 1;30(5):542-565 Authors: Carpenter J, Cherney LR Abstract BACKGROUND: Intensity of therapy is a critical factor influencing outcomes in aphasia. However, there are many barriers to increasing treatment intensity for those with acute/subacute aphasia including the demands of the inpatient medical facilities and the endurance of the participants. Nevertheless, with some modifications to its original procedures, evidence suggests that Constraint Induced L...περισσότερα »
Asking 'What about' questions in chronic illness self-management meetings.
*Asking 'What about' questions in chronic illness self-management meetings.* Patient Educ Couns. 2016 Mar 16; Authors: Fasulo A, Zinken J, Zinken K Abstract OBJECTIVES: This study investigates 'What about' questions asked by patients in the course of diabetes self-management groups led by nurses, and explores their functions in these empowerment-informed settings. METHODS: Conversation Analysis of 24 video-recorded sessions of a Start Insulin Group Programme for patients with type 2 diabetes, in a diabetes centre in the South of England. The groups included 2-7 patients and were l...περισσότερα »
Comparison of Newborn Hearing Screening in Well-Baby Nursery and NICU: A Study Applied to Reduce Referral Rate in NICU.
Related Articles *Comparison of Newborn Hearing Screening in Well-Baby Nursery and NICU: A Study Applied to Reduce Referral Rate in NICU.* PLoS One. 2016;11(3):e0152028 Authors: Li PC, Chen WI, Huang CM, Liu CJ, Chang HW, Lin HC Abstract OBJECTIVES: To determine whether newborn hearing screening in a well-baby nursery (WBN) and neonatal intensive care unit (NICU) nursery: 1) meet three targeted, screening, referral, and diagnostic follow-up rates; 2) compare the average age of diagnosis for infants admitted to the WIN and NICU; and 3) determine prevalence of hearing loss in neonat...περισσότερα »
Treatment for dysphagia (swallowing difficulties) in hereditary ataxia.
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Treatment for dysphagia (swallowing difficulties) in hereditary ataxia.* Cochrane Database Syst Rev. 2015;11:CD010169 Authors: Vogel AP, Keage MJ, Johansson K, Schalling E Abstract BACKGROUND: Hereditary ataxias are a heterogeneous group of disorders resulting in progressive inco-ordination. Swallowing impairment, also known as dysphagia, is a common and potentially life threatening sequel of disease progression. The incidence and nature of dysphagia in these conditions is largely unknown. The loss of an effective ... περισσότερα »
Development and validation of Australian aphasia rehabilitation best practice statements using the RAND/UCLA appropriateness method.
[image: http:--highwire.stanford.edu-icons-exter] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Development and validation of Australian aphasia rehabilitation best practice statements using the RAND/UCLA appropriateness method.* BMJ Open. 2015;5(7):e007641 Authors: Power E, Thomas E, Worrall L, Rose M, Togher L, Nickels L, Hersh D, Godecke E, O'Halloran R, Lamont S, O'Connor C, Clarke K Abstract OBJECTIVES: To develop and validate a national set of best practice statements for use in post-stroke aphasia rehabilitation. DESIGN: Literature review and statement validation u... περισσότερα »
Inner Speech: Development, Cognitive Functions, Phenomenology, and Neurobiology.
[image: http:--content.apa.org-images-shared-Ful] [image: http:--http://ift.tt/1Fkw4zC] Related Articles *Inner Speech: Development, Cognitive Functions, Phenomenology, and Neurobiology.* Psychol Bull. 2015 Sep;141(5):931-65 Authors: Alderson-Day B, Fernyhough C Abstract Inner speech-also known as covert speech or verbal thinking-has been implicated in theories of cognitive development, speech monitoring, executive function, and psychopathology. Despite a growing body of knowledge on its phenomenology, development, and function, approaches to the scientific study of inner speech ... περισσότερα »
The language skeleton after dissecting meaning: A functional segregation within Broca's Area.
[image: http:--linkinghub.elsevier.com-ihub-imag] Related Articles *The language skeleton after dissecting meaning: A functional segregation within Broca's Area.* Neuroimage. 2015 Jul 1;114:294-302 Authors: Goucha T, Friederici AD Abstract Broca's area is proposed as a crucial brain area for linguistic computations. Language processing goes beyond word-level processing, also implying the integration of meaningful information (semantics) with the underlying structural skeleton (syntax). There is an on-going debate about the specialisation of the subregions of Broca's area-Brodmann ... περισσότερα »
Development and characterization of surface engineered PPI dendrimers for targeted drug delivery.
*Development and characterization of surface engineered PPI dendrimers for targeted drug delivery.* Artif Cells Nanomed Biotechnol. 2016 Mar 30;:1-12 Authors: Kaur A, Jain K, Mehra NK, Jain NK Abstract In this study, we reported folate-conjugated polypropylene imine dendrimers (FA-PPI) as efficient carrier for model anticancer drug, methotrexate (MTX), for pH-sensitive drug release, selective targeting to cancer cells, and anticancer activity. In the in vitro drug release studies this nanoconjugate of MTX showed initial rapid release followed by gradual slow release, and the drug... περισσότερα »
GO-PEG as a drug nanocarrier and its antiproliferative effect on human cervical cancer cell line.
*GO-PEG as a drug nanocarrier and its antiproliferative effect on human cervical cancer cell line.* Artif Cells Nanomed Biotechnol. 2016 Mar 30;:1-6 Authors: Bikhof Torbati M, Ebrahimian M, Yousefi M, Shaabanzadeh M Abstract The graphene oxide nanosheets can act as a nanocarrier for the delivery of therapeutic agents. The PEGylated GO has high solubility, good stability, and more biocompatibility in physiological solutions. In this study, the anticancer effects of synthesized GO-PEG as a drug nanocarrier evaluated to estimate the synergistic cytotoxic effect of drugs loaded on thi... περισσότερα »
Recommended European Society of Parenteral and Enteral Nutrition protein and energy intakes and weight loss in patients with head and neck cancer.
*Recommended European Society of Parenteral and Enteral Nutrition protein and energy intakes and weight loss in patients with head and neck cancer.* Head Neck. 2016 Mar 29; Authors: Giles KH, Kubrak C, Baracos VE, Olson K, Mazurak VC Abstract BACKGROUND: Information regarding attenuation of weight loss in patients with head and neck cancer consuming energy and protein intakes at levels recommended by the European Society of Parenteral and Enteral Nutrition (ESPEN) is limited. METHODS: Newly diagnosed patients with head and neck cancer (n = 38) consuming food orally had weight and ...περισσότερα »
Let Them Eat Fish--Reply.
[image: http:--oncology.jamanetwork.com-images-P] Related Articles *Let Them Eat Fish--Reply.* JAMA Oncol. 2015 Sep;1(6):841 Authors: Daenen LG, Voest EE PMID: 26355866 [PubMed - indexed for MEDLINE] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/1SoKsha via IFTTT
Let Them Eat Fish.
[image: http:--oncology.jamanetwork.com-images-P] Related Articles *Let Them Eat Fish.* JAMA Oncol. 2015 Sep;1(6):840-1 Authors: Baracos V PMID: 26355864 [PubMed - indexed for MEDLINE] from #PubMed 1 via ola Kala on Inoreader http://ift.tt/25y7egz via IFTTT
Visually impaired individuals, safety perceptions and traumatic events: a qualitative study of hazards, reactions and coping.
*Visually impaired individuals, safety perceptions and traumatic events: a qualitative study of hazards, reactions and coping.* Disabil Rehabil. 2016 Mar 30;:1-6 Authors: Saur R, Hansen MB, Jansen A, Heir T Abstract PURPOSE: To explore the types of risks and hazards that visually impaired individuals face, how they manage potential threats and how reactions to traumatic events are manifested and coped with. METHOD: Participants were 17 visually impaired individuals who had experienced some kind of potentially traumatic event. Two focus groups and 13 individual interviews were cond...περισσότερα »
