An unusual giant isolated mucosal malignant melanoma of nasal cavity – A case report

Publication date: Available online 12 November 2016
Source:Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Author(s): Santosh Kumar Swain, Mahesh Chandra Sahu
The mucosal malignant melanoma arises from the melanocytes present in the mucosal membrane. It carries a poor prognosis due to local recurrence, neck node involvement and distant metastasis, making it difficult to identify the possible treatment. The key and critical issue for the management of the malignant melanoma of the nasal cavity is early diagnosis in order to start primary modality of treatment like surgical excision and radiotherapy with adequate follow up. We report a case of malignant melanoma of the nasal cavity in a 65years old male with presentation of recurrent epistaxis and nasal obstruction. Rarity of this isolated lesion confined to nasal cavity with a giant size warrants its attention for reporting this case.



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Epidermal growth factor receptor (EGFR) pathway polymorphisms as predictive markers of cetuximab toxicity in locally advanced head and neck squamous cell carcinoma (HNSCC) in a Spanish population

Publication date: December 2016
Source:Oral Oncology, Volume 63
Author(s): J. Fernández-Mateos, R. Seijas-Tamayo, R. Mesía, M. Taberna, M. Pastor Borgoñón, E. Pérez-Ruiz, J.C. Adansa Klain, S. Vázquez Fernández, E. del Barco Morillo, A. Lozano, R. González Sarmiento, J.J. Cruz-Hernández
ObjectivesTo examine the relationship between polymorphisms of the epidermal growth factor receptor (EGFR) pathway and toxicity in head and neck squamous cell carcinoma (HNSCC) patients treated with cetuximab.Material and methodsMulticenter, retrospective, observational pilot study which included 110 patients with histologically-confirmed human papillomavirus (HPV) negative HNSCC in locally advanced stages (III-IVA-B) and who were treated with chemotherapy and radiotherapy plus cetuximab between 2003 and 2013. Genetic analyses for single nucleotide polymorphisms (SNP) in genes EGFR, CCDN1, FCGR2A, FCGR3A and KRAS-LCS6 were performed though available allelic discrimination assay and/or polymerase chain reaction-restriction fragment length polymorphism methods.ResultsAcneiform rash was observed in 55.5% of patients, dry skin in 45.5% and pruritus in 20.9%. A significant association with dry skin and global cetuximab-related toxicity was observed for the KRAS-LCS6 (rs61764370) variant (p<0.05); carriers of the G allele (genotypes TG+GG) in the dominant model were observed to have a decreased susceptibility of developing dry skin (OR=0.287 [95%CI=0.119–0.695]). Carriers of the A (GA+AA) allele for EGFR (rs2227983) showed a decreased risk of suffering from pruritus (OR=0.345 [0.124–0.958]). Similarly, KRAS (rs1801274) was related with lower global cetuximab-related toxicity (OR=0.266 [0.114–0.622]).ConclusionThis pilot study provides preliminary evidence supporting genetic variation of EGFR (rs2227983), KRAS (rs61764370) and FCGR2A (rs180127) as useful biomarkers for predicting reduced skin toxicity in HNSCC patients treated with a cetuximab-based therapy. Alternative therapeutic options should be explored for these patients.



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Reply

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Hadi Maazi, Yuzo Suzuki, Jae Jung, Omid Akbari




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A possible differential role of autophagy in asthma?

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Ulaganathan Mabalirajan




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Proficient DNA repair in house dust mite–induced asthma?

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Rakhshinda Rehman, Ulaganathan Mabalirajan




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Hematopoietic Stem Cell Transplant in Patients with Activated PI3K Delta Syndrome

Publication date: Available online 12 November 2016
Source:Journal of Allergy and Clinical Immunology
Author(s): Zohreh Nademi, Mary A. Slatter, Christopher C. Dvorak, Benedicte Neven, Alain Fischer, Felipe Suarez, Claire Booth, Kanchan Rao, Alexandra Laberko, Julia Rodina, Yves Bertrand, Sylwia Kołtan, Robert Dębski, Terence Flood, Mario Abinun, Andrew R. Gennery, Sophie Hambleton, Stephan Ehl, Andrew J. Cant




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Two Different Life-Threatening Cases: Presenting with Torticollis

Acquired torticollis can be the result of several different pathological mechanisms. It is generally related to trauma, tumors, and inflammatory processes of the cervical muscles, nerves, and vertebral synovia. Although upper respiratory tract and neck inflammation are common causes of acute febrile torticollis in children, diseases with as yet undefined relationships may also result in torticollis. This is the case of spinal arachnoid cyst and pneumonia.

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