Endotypes in Chronic Rhinosinusitis: Biomarkers Based on a Mechanistic Insight for Targeted Treatment?

Chronic rhinosinusitis is an umbrella term for several phenotypes and mechanistically distinct inflammatory diseases of the nose and the paranasal sinuses affecting around 11% of the population in Europe and the USA. Approximately 20% of the patients present with uncontrolled disease despite adequate treatment, and revision surgery is common. While a clinical characterization alone does not improve treatment results, novel but expensive biologics have increasingly become available, but they require a better understanding of the mechanism. Mechanistic markers of disease may help to allocate the optimal drug to a patient, thus reducing undesirable side effects and avoiding unnecessary treatment and costs with respect to potential non-responders, thereby increasing responder rates and compliance.
ORL 2017;79:78-84

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BK Virus Encephalitis in HIV-Infected Patients: Case Report and Review

Encephalitis and meningitis due to BKPyV are unusual and emerging condition. Only a few cases of BKPyV encephalitis have been reported in hematopoietic stem cell transplant recipients, with the majority of cases presenting with concurrent hemorrhagic cystitis and HIV-infected patients. The authors report two HIV-infected patients with the diagnosis of BKPyV encephalitis and discuss the main clinical, diagnostic, and therapeutic aspects of this infection in patients with AIDS. Physicians should be aware to recognize the main clinical features and diagnose BKPyV central nervous infection in the setting of AIDS.

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Bilateral Mydriasis Secondary to Propofol Administration in a Patient With Hypertensive Cerebellar Hemorrhage.

No abstract available

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Cerebral Sinus Thrombosis in Parturient.

No abstract available

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Life-threatening Tachyarrhythmia Following Intra-Arterial Milrinone for Cerebral Vasospasm.

No abstract available

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Neuroanesthesiology Update.

We reviewed manuscripts published in 2016 that are related to the care of neurosurgical patients or the perioperative care of patients with neurological diseases. We address the broad categories of general neurosurgery and neuroanesthesiology, anesthetic neurotoxicity and neuroprotection, stroke, traumatic brain injury, and nervous system monitoring. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved

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Journal Club.

No abstract available

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