Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Παρασκευή 19 Μαΐου 2017

Immune cell signaling in autoimmune diseases

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Publication date: Available online 19 May 2017
Source:Clinical Immunology
Author(s): George C. Tsokos, Noel R. Rose
On September 20, 2016 the American Autoimmune Related Disease Association convened a selected group of16 experts in Washington DC to discuss current issues and future directions of research in autoimmune diseases from the cell signaling perspective. The major topics considered included new findings on the follicular T cell cells in mice, their metabolic patterns and their control by the newly discovered T follicular regulatory cells. Current work on the metabolic pathways deemed important for the function of T cells was presented. The broader implications of these studies on our understanding of human and murine T regulatory cell and current aspects of B cell biology, innate immunity and organ damage were discussed. This document should provide the reader with a quick update on these topics and help instigate novel studies.



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Decrease of blood anti-α1,3 Galactose Abs levels in multiple sclerosis (MS) and clinically isolated syndrome (CIS) patients

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Publication date: July 2017
Source:Clinical Immunology, Volume 180
Author(s): L. Le Berre, J. Rousse, P.-A. Gourraud, B.-M. Imbert-Marcille, A. Salama, G. Evanno, G. Semana, A. Nicot, E. Dugast, P. Guérif, C. Adjaoud, T. Freour, S. Brouard, F. Agbalika, R. Marignier, D. Brassat, D.-A. Laplaud, E. Drouet, V. Van Pesch, J.-P. Soulillou
The etiology of multiple sclerosis (MS) remains elusive. Among the possible causes, the increase of anti-Neu5Gc antibodies during EBV primo-infection of Infectious mononucleosis (IMN) may damage the integrity of the blood-brain barrier facilitating the transfer of EBV-infected B cells and anti-EBV T cell clones in the brain.We investigated the change in titers of anti-Neu5Gc and anti-α1,3 Galactose antibodies in 49 IMN, in 76 MS, and 73 clinically isolated syndrome (CIS) patients, as well as age/gender-matched healthy individuals.Anti-Gal and anti-Neu5Gc are significantly increased during IMN (p=0.02 and p<1.10−4 respectively), but not in acute CMV primo-infection. We show that, whereas there was no change in anti-Neu5Gc in MS/CIS, the two populations exhibit a significant decrease in anti-Gal (combined p=2.7.10−3), in contrast with patients with non-MS/CIS central nervous system pathologies.Since anti-Gal result from an immunization against α1,3 Gal, lacking in humans but produced in the gut, our data suggest that CIS and MS patients have an altered microbiota or an altered response to this microbiotic epitope.



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Publication date: Available online 18 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Peter K. Smith, Madhan Masilamani, Xiu-Min Li, Hugh A. Sampson




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Polyfunctionality of bona fide resident lung CD69+ natural killer cells

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Publication date: Available online 18 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Baptiste Hervier, Isabelle Cremer, Vincent Vieillard




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Publication date: Available online 18 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Nicole Marquardt, Hans-Gustaf Ljunggren, Jakob Michaëlsson




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Additional effects of dietary advanced glycation end products

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Publication date: Available online 18 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Jeffrey D. Miller




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Cockroach Allergy and Urban Asthma

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Publication date: Available online 19 May 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Peyton A. Eggleston




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