Journal of Antibiotics

Alexandros Sfakianakis

Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

TABLE OF CONTENTS Volume 70, Issue 6 (June 2017) In this issue Original Articles Notes Also new  AOP   Sign up for e-alerts   Recommend to your library   Web feed    Subscribe ORIGINAL ARTICLES Top Trienylfuranol A and trienylfuranone A–B: metabolites isolated from an endophytic fungus, Hypoxylon submoniticulosum, in the raspberry Rubus idaeus Kevin M N Burgess, Ashraf Ibrahim, Dan Sørensen and Mark W Sumarah J Antibiot 2017 70: 721-725; advance online publication, March 1, 2017; 10.1038/ja.2017.18 Abstract | Full Text OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum Catalina F Pérez Hemphill, Parichat Sureechatchaiyan, Matthias U Kassack, Raha S Orfali, Wenhan Lin, Georgios Daletos and Peter Proksch J Antibiot 2017 70: 726-732; advance online publication, March 8, 2017; 10.1038/ja.2017.21 Abstract | Full Text Ghanamycins A and B, two novel γ-butyrolactones from marine-derivedstreptomyces ghanaensis TXC6-16 Jia-hui Xu, Kang-bo Gu, Dao-Jing Zhang, Yuan-Guang Li and Li Tian J Antibiot 2017 70: 733-736; advance online publication, March 15, 2017; 10.1038/ja.2017.37 Abstract | Full Text Bioactive secondary metabolites produced by an endophytic fungusGaeumannomyces sp. JS0464 from a maritime halophyte Phragmites communis Changyeol Lee, Soonok Kim, Wei Li, Sunghee Bang, Hanna Lee, Hyun-Jung Lee, Eun-Young Noh, Jung-Eun Park, Woo Young Bang and Sang Hee Shim J Antibiot 2017 70: 737-742; advance online publication, March 29, 2017; 10.1038/ja.2017.39 Abstract | Full Text Two new polyketides from the ascomycete fungus Leptosphaeria sp. Jie Lin, Renlei Wang, Guohua Xu, Zhengfeng Ding, Xueshen Zhu, Erwei Li and Ling Liu J Antibiot 2017 70: 743-746; advance online publication, February 15, 2017; 10.1038/ja.2017.5 Abstract | Full Text Streptomyces euryhalinus sp. nov., a new actinomycete isolated from a mangrove forest Kaushik Biswas, Jayanta D Choudhury, Riddhi Mahansaria, Malay Saha and Joydeep Mukherjee J Antibiot 2017 70: 747-753; advance online publication, February 8, 2017; 10.1038/ja.2017.3 Abstract | Full Text In vitro antibacterial activity of MGDG-palmitoyl from Oscillatoria acuminataNTAPC05 against extended-spectrum β-lactamase producers Abdul Azees Parveez Ahamed, Mohammed Uddin Rasheed, Kalilurrahuman Peer Muhamed Noorani, Nazar Reehana, Subramanian Santhoshkumar, Yousuff Mohamed Mohamed Imran, Naiyf S Alharbi, Chinnathambi Arunachalam, Sulaiman Ali Alharbi, Mohammad Abdulkader Akbarsha and Nooruddin Thajuddin J Antibiot 2017 70: 754-762; advance online publication, April 5, 2017; 10.1038/ja.2017.40 Abstract | Full Text Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candidaalbicans biofilm formation and hyphal growth Jie Wang, Qi-Feng Yao, Muhammad Amin, Xu-Hua Nong, Xiao-Yong Zhang and Shu-Hua Qi J Antibiot 2017 70: 763-770; advance online publication, April 5, 2017; 10.1038/ja.2017.45 Abstract | Full Text Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya and Kazuhisa Sekimizu J Antibiot 2017 70: 771-774; advance online publication, February 15, 2017; 10.1038/ja.2017.7 Abstract | Full Text The efficacy of different anti-microbial metals at preventing the formation of, and eradicating bacterial biofilms of pathogenic indicator strains Natalie Gugala, Joe A Lemire and Raymond J Turner J Antibiot 2017 70: 775-780; advance online publication, February 15, 2017; 10.1038/ja.2017.10 Abstract | Full Text Formal synthesis of Thienamycin Michał Pieczykolan, Bartłomiej Furman and Marek Chmielewski J Antibiot 2017 70: 781-787; advance online publication, April 5, 2017; 10.1038/ja.2017.44 Abstract | Full Text NOTES Top Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample Bin Yang, Huaming Tao, Xiao-Chu Qin, Zhen Wang, Junde Dong, Xiuping Lin, Xuefeng Zhou, Jian-Lin Li, Zheng-Chao Tu and Yonghong Liu J Antibiot 2017 70: 788-790; advance online publication, January 25, 2017; 10.1038/ja.2016.169 Full Text Acremopeptin, a new peptaibol from Acremonium sp. PF1450 Masatomi Iijima, Masahide Amemiya, Ryuichi Sawa, Yumiko Kubota, Takao Kunisada, Isao Momose, Manabu Kawada and Masakatsu Shibasaki J Antibiot 2017 70: 791-794; advance online publication, February 15, 2017; 10.1038/ja.2017.15 Full Text New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066 Mingwei Sun, Xiaotong Chen, Wenjun Li, Chunhua Lu and Yuemao Shen J Antibiot 2017 70: 795-797; advance online publication, April 5, 2017; 10.1038/ja.2017.46 Full Text Identification of tirandamycins as specific inhibitors of the futalosine pathway Yasushi Ogasawara, Kensuke Kondo, Ayumi Ikeda, Rikako Harada and Tohru Dairi J Antibiot 2017 70: 798-800; advance online publication, March 1, 2017; 10.1038/ja.2017.22 Full Text Molecular epigenetic approach activates silent gene cluster producing dimeric bis-spiro-azaphilones in Chaetomium globosum CBS148.51 Meng-Hua Wang, Tao Jiang, Gang Ding, Shu-Bin Niu, Xue-Wei Wang, Meng Yu, Yu-Cheng Gu, Qiu-Bo Zhang, Jia-Huan Chen, Hong-Mei Jia and Zhong-Mei Zou J Antibiot 2017 70: 801-804; advance online publication, March 1, 2017; 10.1038/ja.2017.4 Full Text Conjugative ESBL plasmids differ in their potential to rescue susceptible bacteria via horizontal gene transfer in lethal antibiotic concentrations Sari Mattila, Pilvi Ruotsalainen, Ville Ojala, Timo Tuononen, Teppo Hiltunen and Matti Jalasvuori J Antibiot 2017 70: 805-808; advance online publication, March 29, 2017; 10.1038/ja.2017.41 Full Text Biochemical characterization of CTX-M-166, a new CTX-M β-lactamase produced by a commensal Escherichia coli isolate Vera Manageiro, Rafael Graça, Eugénia Ferreira, Lurdes Clemente, Richard Bonnet and Manuela Caniça J Antibiot 2017 70: 809-810; advance online publication, April 5, 2017; 10.1038/ja.2017.42 Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events

Targeting the programmed cell death-1 pathway in rheumatoid arthritis

Publication date: Available online 29 May 2017
Source:Autoimmunity Reviews
Author(s): Sabina Sandigursky, Gregg J. Silverman, Adam Mor
Since the introduction of TNF-α inhibitors and other biologic agents, the clinical outcome for many treated rheumatoid arthritis patients has significantly improved. However, there are still a substantial proportion of patients that are intolerant, or have inadequate responses, with current agents that have become the standards of care. While the majority of these agents are designed to affect the inflammatory features of the disease, there are also agents in the clinic that instead target lymphocyte subsets (e.g., rituximab) or interfere with lymphocyte co-receptor signaling pathways (e.g., abatacept). Due in part to their ability to orchestrate downstream inflammatory responses that lead to joint damage and disease progression, pathogenic expansions of T and B lymphocytes are appreciated to play key roles in the pathogenesis of rheumatoid arthritis. New insights into immune regulation have suggested novel approaches for the pharmacotherapeutic targeting of lymphocytes. In this review, we discuss deepening insights into human genetics and our understanding of the interface with rheumatoid arthritis pathogenesis providing a strong rationale for exploiting the co-inhibitory receptor programmed cell death-1 signaling pathway as a better approach for the treatment of this chronic, often progressive destructive joint disease.



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Auto-antibodies and cancer in Systemic Sclerosis

Publication date: Available online 29 May 2017
Source:Autoimmunity Reviews
Author(s): Maaike Boonstra, Tom W.J. Huizinga, Jeska K. de Vries-Bouwstra




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Hematopoietic stem cell transplantation in autoimmune disorders: From immune-regulatory processes to clinical implications

Publication date: Available online 29 May 2017
Source:Autoimmunity Reviews
Author(s): Margit Zeher, Gábor Papp, Britt Nakken, Peter Szodoray
Autoimmune diseases are characterized by the development of autoreactive T- and B-cells targeting self-antigens, which eventually can result in chronic and persistent organ damage. The autologous hematopoietic stem cell transplantation (AHSCT) opened new avenues in the treatment of patients with severe, treatment-resistant autoimmune diseases. This paper reviews the immune-regulatory mechanisms behind AHSCT, and also summarizes the experiences of clinical practice related to the therapy in organ-specific and systemic autoimmune diseases.It seems that the intricate interplay of various immune competent cells with regulatory capacity control in a synergistic manner the repopulated immune system after AHSCT, which potentially leads to a significant clinical improvement in certain autoimmune diseases. However, the widespread use of AHSCT was intrinsically limited, due to the serious side-effects of conditioning treatment and relatively high treatment-related mortality; moreover, the development of new effective and safe therapeutic approaches and the dawn of biological agents further limited its indications in the last decade. Nevertheless, with an appropriate patient selection and increased experience of transplant centres, the risks can be minimized, and AHSCT remained still a reasonable choice in multiple sclerosis and systemic sclerosis when the conventional therapy failed and further progression of disease is inevitable.



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The combination of overweight and smoking increases the severity of androgenetic alopecia

Abstract

Introduction

Even though androgenetic alopecia (AGA) is the most common type of alopecia, factors associated with AGA severity have been poorly investigated.

Objectives

The objective of our study was to investigate risk factors for AGA severity among a Caucasian population.

Methods

A cross-sectional study was conducted among AGA subjects in the outpatient clinic of a reference hospital for skin diseases in Rome, Italy. A total of 351 Caucasian subjects with AGA, mean age 35.6 years, were enrolled in the study. Information on educational level, family history of AGA, diet, alcohol consumption, the presence of chronic diseases, the use of pills including dietary supplements, BMI, and smoking was collected by a face-to-face interview using standardized questionnaires. Norwood and Ludwig classifications were used to assess the degree of AGA.

Results

Subjects with a BMI of 25 or more and current smokers had circa six times an increased risk of having moderate or severe AGA (OR: 6.72; 95% CI: 2.57–17.6). In the multivariate model, after controlling for gender, age, education, dyslipidemia, dietary supplements, and wine consumption, the effect of high BMI and smoking (OR: 5.96; 95% CI: 1.65–21.5) on AGA severity remained. Only age and gender, besides the effect of BMI and smoking, remained statistically significant in the multivariate model while education, the presence of dyslipidemia, dietary supplements, and wine consumption did not remain statistically significant.

Conclusions

Our study shows that the combination of overweight and smoking is associated with an increased severity of androgenetic alopecia.

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Warfarin-induced skin necrosis accompanied by aggravation of vasculitis in a patient with cutaneous arteritis

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Erratum

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