Corrigendum to “Management Challenges in a Child with Chronic Hyponatremia: Use of V2 Receptor Antagonist”

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Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice

Publication date: Available online 1 July 2017
Source:Allergology International
Author(s): Ken Fukuda, Waka Ishida, Yosuke Harada, Yuhya Wakasa, Hidenori Takagi, Fumio Takaiwa, Atsuki Fukushima
BackgroundWe have previously shown that prophylactic oral administration of transgenic rice seeds expressing hypoallergenic modified antigens suppressed the development of allergic conjunctivitis induced by Japanese cedar pollen. We have now investigated the efficacy of oral immunotherapy with such transgenic rice for established allergic conjunctivitis in mice.MethodsBALB/c mice were sensitized with two intraperitoneal injections of Japanese cedar pollen in alum, challenged with pollen in eyedrops, and then fed for 16 days with transgenic rice seeds expressing modified Japanese cedar pollen allergens Cry j 1 and Cry j 2 or with nontransgenic rice seeds as a control. They were then challenged twice with pollen in eyedrops, with clinical signs being evaluated at 15 min after the first challenge and the eyes, blood, spleen, and lymph nodes being isolated at 24 h after the second challenge.ResultsThe number of eosinophils in the conjunctiva and the clinical score for conjunctivitis were both significantly lower in mice fed the transgenic rice than in those fed nontransgenic rice. Oral vaccination with transgenic rice seeds also resulted in a significant increase in the production of IFN-γ by splenocytes, whereas it had no effect on the number of CD4⁺CD25⁺Foxp3⁺ regulatory T cells in the spleen or submandibular or mesenteric lymph nodes.ConclusionsOral administration of transgenic rice seeds expressing hypoallergenic allergens ameliorated allergic conjunctivitis in the established setting. Such a rice-based edible vaccine is potentially both safe and effective for oral immunotherapy in individuals with allergic conjunctivitis.



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Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature

Sertoli-Leydig Cell Tumors (SLCTs) make up

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Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.

Palate perforation differentiates cocaine-induced midline destructive lesions from granulomatosis with polyangiitis.

Acta Otorhinolaryngol Ital. 2017 Jun 30;:

Authors: Trimarchi M, Bondi S, Della Torre E, Terreni MR, Bussi M

Abstract
Cocaine abuse occasionally causes extensive destruction of the osteocartilaginous structures of the nose, sinuses and palate, which mimics the clinical picture of other diseases associated with necrotising midfacial lesions. The differentiation of cocaine-induced midline destructive lesions (CIMDL) and limited granulomatosis with polyangiitis (GPA) may be difficult, particularly if patients do not readily admit substance abuse. We studied 10 patients with CIMDL and palate perforation referred to our Unit between 2002 and 2015. All cases underwent nasal endoscopy, sinus CT or MRI and ANCA test. In 8 patients, a nasal biopsy was performed. The PubMed database was searched to review all cases of palate perforation described in patients affected by CIMDL or GPA. All 10 cases presented with septal perforation and inferior turbinate destruction. We found hard palate perforation in 7 patients, soft palate perforation in 2 patients, and perforation of both in one patient. ANCA testing was negative in 8 patients and positive in 2, with C-ANCA and P-ANCA specificity, respectively. A review of the English literature identified palate perforation in 5 patients with GPA and in 73 patients with CIMDL. The presence of palate perforation in patients with MDL may represent a clinical marker that strongly favors CIMDL over GPA.

PMID: 28663599 [PubMed - as supplied by publisher]

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Cost-effectiveness strategies in OSAS management: a short review.

Cost-effectiveness strategies in OSAS management: a short review.

Acta Otorhinolaryngol Ital. 2017 Jun 30;:

Authors: Toraldo DM, Passali D, Sanna A, De Nuccio F, Conte L, De Benedetto M

Abstract
Obstructive sleep apnoea (OSAS) is an underdiagnosed chronic disease with a high prevalence in adults. It is becoming a significant social problem, since it is associated with a worsening in quality of life and increase in mortality. The cost-effectiveness ratio of diagnostic and therapeutic management of OSAS is a strategic issue to counteract the expected increasing demand of objective testing. OSAS patients with any clinical evidence of comorbidities must be studied using simplified and less expensive systems such as Home Sleep Testing (HST). On the other hand, Sleep Laboratory Polysomnography (PSG) is the gold standard to manage OSAS patients with comorbidities. It should be pointed out that the use of HST can lead to incorrect diagnosis in poorly selected OSAS subjects. This short review discusses various topics for the proper diagnosis and treatment of OSAS in view of epidemiological factors and results in terms of costs and social benefit of the disease. Whatever the strategy chosen and/or the organisational model adopted for managing OSAS, it cannot and should not take into account only cost-effectiveness. Long-term prospective studies evaluating cost-effectiveness ratios and outcomes of OSAS treatment of hospital management models versus home care models are needed.

PMID: 28663598 [PubMed - as supplied by publisher]

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Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.

Prognostic factors in head and neck cancer: a 10-year retrospective analysis in a single-institution in Italy.

Acta Otorhinolaryngol Ital. 2017 Jun 30;:

Authors: Cadoni G, Giraldi L, Petrelli L, Pandolfini M, Giuliani M, Paludetti G, Pastorino R, Leoncini E, Arzani D, Almadori G, Boccia S

Abstract
This study was undertaken to evaluate the association between demographics, lifestyle habits, and clinical data and overall survival (OS), recurrence and second primary cancer (SPC) in patients with first primary head and neck cancer (HNC). We retrospectively reviewed data from 482 patients treated at the "Agostino Gemelli" Teaching Hospital, Rome, between 2002-2012 for primary HNC. Individual parameters were evaluated for association with specific outcomes such as OS, cancer recurrence and second primary cancer (SPC) appearance using hazard ratios (HR) and 95% confidence intervals (CIs). Five-year OS was 60.6% for all HNC cases, 49.0% for oral cavity, 54.8% for oropharynx, 50.0% for hypopharynx and 63.4% for larynx. Predictors of OS were older age (HR = 1.04; 95% CI: 1.02-1.05) and advanced tumour stage (HR = 2.00; 95% CI: 1.41-2.84). The risk of recurrence was associated with drinking 8-14 drinks per week (HR = 1.73; 95% CI: 1.00-2.97). The risk of developing SPC increased with advanced tumour stage (HR = 2.75; 95% CI: 1.39-5.44) and with smoking for more than 40 years (HR = 3.68; 95% CI: 1.10-12.30). OS differed among HNC sites. Increasing age was an unfavourable predictor of HNC OS. Tumour stage was a prognostic factor both for OS and for risk of developing SPC. Alcohol and tobacco consumption were prognostic factors for recurrence and SPC, respectively.

PMID: 28663597 [PubMed - as supplied by publisher]

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Epinephrine use for anaphylaxis: Too seldom, too late

During the past 20 years, food allergy has dramatically increased, with a concomitant increased risk for anaphylaxis.1 Anaphylaxis is "a serious allergic reaction that is rapid in onset and may cause death."2 Foods are one of the common causes of anaphylaxis3 over medications and insect stings, and food allergy has become a worldwide concern. Anaphylaxis is inadequately treated most of the time4 because of inconsistent signs and symptoms; anaphylaxis can manifest differently in the same person, even when triggered by the same allergen.

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