miRNA – rola i znaczenie w astmie oskrzelowej

Publication date: Available online 1 August 2017
Source:Alergologia Polska - Polish Journal of Allergology
Author(s): Maksymilian Ziaja, Rafał Pawliczak
Chronic inflammatory airway diseases, including asthma, are a significant health problem and previous treatment methods seem to be insufficient. There is a lack of effective therapies which are adjusted to treat all classes in terms of severity, and it is probably caused by insufficient understanding of molecular mechanisms involved in its occurrence. Small non-coding microRNA molecules in response to environmental factors lead to modulate gene expression. They regulate many processes associated with physiologic functions of the immune system. Researches showed crucial role of miRNA in pathogenesis of asthma and the other chronic inflammatory airway diseases. Despite the link of microRNA with pathogenesis of inflammatory airway diseases, the role of these molecules is still unclear. More detailed knowledge of the impact of miRNA molecules on the development of bronchial asthma would allow us to better understand the genesis process and might influence the effectiveness of the bronchial asthma treatment.



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Role of metastasectomy and chemotherapy in carcinoma of uterine cervix

Squamous cell carcinoma of uterine cervix is potentially a curable disease; however, many patients treated with definitive chemoradiotherapy develop distant metastases, with few of them having a single metastatic deposit. There are no guidelines for the treatment of patients with oligometastatic cervical cancer.

We present a case of a patient with International Federation of Gynecology and Obstetrics (FIGO) Stage IIB squamous cell carcinoma of uterine cervix. She was successfully treated with concurrent chemoradiotherapy with definitive intent. One year later, she developed a solitary pulmonary nodule for which she underwent resection followed by chemotherapy. She is free of any local or distant disease at 5 years of regular follow-up.

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Diagnosis of acrodermatitis enteropathica in resource limited settings

Acrodermatitis enteropathica (AE) is a rare inherited zinc deficiency that usually manifests in infancy within days in cases of bottlefed infants and days to weeks after weaning in breastfed infants. It is characterised by diarrhoea, dermatitis, alopecia and systemic symptoms. We report a case of acquired nutritional AE in a 6-month-old female infant who had diarrhoeal episodes and the characteristic dermatitis lesions in the acral and anogenital regions. She responded dramatically to oral zinc supplementation.

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Paget-Schroetter syndrome complicated by an incidental pulmonary embolism

A young man presented with the severe right upper limb swelling following a heavy weight lifting that was thought to be caused by a biceps tendon rupture. However, subsequent investigations confirmed the diagnosis of Paget-Schroetter syndrome that was associated with an incidental pulmonary embolism. The patient underwent a successful thrombolysis followed by a surgical thoracic outlet decompression. Overall, the patient has made a good recovery.

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Self-medication complicating pseudo membranous conjunctivitis

We aim to highlight the prevalence of using local medications for curing eye ailments in a rural population and the harmful consequence of resultant disease, ranging from something as mild as conjunctivitis to sight-threatening conditions. This case report will address one such incidence where in a local village, the doctor known as a registered medical practitioner) in the rural community, uses local remedies for his conjunctivitis and ends up in a condition where he cannot see anything beyond perceiving light. The membrane removal and treatment with topical antibiotic cured his infection, restoring complete recovery of vision. This incidence inspired the local village doctor to become an eye health educator. He was motivated to spread awareness about the ill effects of self-medication on eye health. He is also determined to bring all blind people and others who need eye care from his remote village to our centre.

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An illusion of septic shock: acute generalised exanthematous pustulosis with multiorgan dysfunction

Acute generalised exanthematous pustulosis (AGEP) is a rare cutaneous eruption, most often caused by commonly used antibiotics. It is characterised by an acute onset of non-follicular sterile pustular rash and erythema within hours or days of drug exposure and usually resolves spontaneously within 1–2 weeks once the drug is discontinued. Haemodynamic involvement in the form of shock is rare. Here, we present a severe case of AGEP, manifesting with systemic involvement and haemodynamic instability resulting in shock with multiorgan dysfunction. The associated drugs were erythromycin and fluconazole with a possible combined effect of these two drugs that resulted in systemic involvement. Our patient improved markedly, both haemodynamically and dermatologically, after discontinuation of the drugs and with systemic steroid therapy.

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Percutaneous valve in valve in the tricuspid position in a patient with Tetralogy of Fallot

Here, we describe a case of a successful percutaneous insertion of a transcatheter 29 mm Edwards Sapien XT valve into a tricuspid valve in a patient with repaired tetralogy of fallot.

Similar procedures have been performed with the Edwards Sapien valve and Melody valves; however, this is the first case described in the literature of an Edwards Sapien valve used in a patient with Tetralogy of Fallot.

With procedural safety being demonstrated, this case illustrates an important alternative treatment option for patients with congenital heart disease. Although long-term data is required to compare its efficacy with surgically replaced valves, percutaneous procedures can serve as a delay to surgical valve replacement which over a patients' lifetime with congenital heart disease, can minimise the amount of invasive surgeries and potential complications.

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