Influence of glutamate-evoked pain and sustained elevated muscle activity on blood oxygenation in the human masseter muscle

This study aimed to investigate the effect of glutamate-evoked masseter muscle pain on intramuscular oxygenation during rest and sustained elevated muscle activity (SEMA). Seventeen healthy individuals participated in two sessions in which they were injected with glutamate and saline in random order. Each session was divided into three, 10-min periods. During the first (period 1) and the last (period 3) 10-min periods, participants performed five intercalated 1-min bouts of masseter SEMA with 1-min periods of 'rest'. At onset of the second 10-min period, glutamate (0.5 ml, 1 M; Ajinomoto, Tokyo, Japan) or isotonic saline (0.5 ml; 0.9%) was injected into the masseter muscle and the participants kept the muscle relaxed in a resting position for 10 min (period 2). The hemodynamic characteristics of the masseter muscle were recorded simultaneously during the experiment by a laser blood-oxygenation monitor. The results demonstrated that glutamate injections caused significant levels of self-reported pain in the masseter muscle; however, this nociceptive input did not have robust effects on intramuscular oxygenation during rest or SEMA tasks. Interestingly, these findings suggest an uncoupling between acute nociceptive activity and hemodynamic parameters in both resting and low-level active jaw muscles. Further studies are needed to explore the pathophysiological significance of blood-flow changes for persistent jaw-muscle pain conditions.

http://ift.tt/2h5E7OB

Nationwide French Study of RET Variants Detected from 2003 to 2013 Suggests a Possible Influence of Polymorphisms as Modifiers

Thyroid , Vol. 0, No. 0.


http://ift.tt/2h4LC8P

Most cited publications in oral and maxillofacial surgery: a bibliometric analysis

Abstract

Background

Citation is one of the most important forms of acknowledgment and recognition received by our peers in academia. This study identifies and characterizes the current topmost highly cited publications in journals specifically dedicated to the specialty. The purpose of this study is to identify, using the citation count, works that have made key contributions in the field and to provide insight into the direction the specialty has taken in the last 30 years.

Methods

Four journals that were dedicated to the field of oral and maxillofacial surgery (OMFS) were selected. The SCOPUS database was utilized to perform a citation analysis on the top 200 publications in the month of May, 2017. Each publication was individually reviewed for the number of citations, the source journal of the manuscript, its year of publications, the article type, the country of origin, the study type, and the level of evidence. We categorized every manuscript within a subspecialty.

Results

The number of citations ranged from 2824 to 118 over the last four decades. The majority of the manuscripts were published in the Journal of Oral and Maxillofacial Surgery (60.5%) followed by the International Journal of Oral and Maxillofacial Surgery (25%). Only 3% of these publications were of level I evidence. The most frequent field of publication was benign pathology (18.5%) followed by dental implantology (19%) and then craniomaxillofacial trauma (12%) and craniomaxillofacial deformities (12%). The majority of the publications were articles, of which 59.5% were case-control, case series, or cohort studies. Nine of the top 20 most cited articles and 12.5% of all the most cited papers were related to osteoradionecrosis, osteochemonecrosis, and bisphosphonates. The majority of these publications originated in the USA (44%), followed by Sweden (9.20%), the Netherlands and UK (7.76%), and Germany (5.82%).

Conclusion

Despite considerable advances in the quality of both clinical and laboratory research, only six level I studies were identified. Osteonecrosis/bisphosphonates and platelet-rich plasma were frequent topics indicating the recent interests in these fields. The USA has continued to play a major role in the research; however, there needs to be more international, multi-institutional cooperative collaborations.

http://ift.tt/2lQecQa

A case of traumatic infraorbital neuroma

Abstract

A 53-year-old Afghan man presented with a 12-month history of left proptosis, diplopia and facial swelling 20 years after a bomb blast injury. Magnetic resonance and computed tomography imaging revealed a well-circumscribed lesion centred within the left inferior orbit/superior maxillary sinus along with left orbital fracture. Histopathology and immunostaining of the debulked lesion were consistent with traumatic neuroma of the infraorbital nerve. Infraorbital neuromas have developed following orbital decompression surgeries but have not been reported previously following non-surgical trauma.

http://ift.tt/2ytnjMG

Most cited publications in oral and maxillofacial surgery: a bibliometric analysis

Abstract

Background

Citation is one of the most important forms of acknowledgment and recognition received by our peers in academia. This study identifies and characterizes the current topmost highly cited publications in journals specifically dedicated to the specialty. The purpose of this study is to identify, using the citation count, works that have made key contributions in the field and to provide insight into the direction the specialty has taken in the last 30 years.

Methods

Four journals that were dedicated to the field of oral and maxillofacial surgery (OMFS) were selected. The SCOPUS database was utilized to perform a citation analysis on the top 200 publications in the month of May, 2017. Each publication was individually reviewed for the number of citations, the source journal of the manuscript, its year of publications, the article type, the country of origin, the study type, and the level of evidence. We categorized every manuscript within a subspecialty.

Results

The number of citations ranged from 2824 to 118 over the last four decades. The majority of the manuscripts were published in the Journal of Oral and Maxillofacial Surgery (60.5%) followed by the International Journal of Oral and Maxillofacial Surgery (25%). Only 3% of these publications were of level I evidence. The most frequent field of publication was benign pathology (18.5%) followed by dental implantology (19%) and then craniomaxillofacial trauma (12%) and craniomaxillofacial deformities (12%). The majority of the publications were articles, of which 59.5% were case-control, case series, or cohort studies. Nine of the top 20 most cited articles and 12.5% of all the most cited papers were related to osteoradionecrosis, osteochemonecrosis, and bisphosphonates. The majority of these publications originated in the USA (44%), followed by Sweden (9.20%), the Netherlands and UK (7.76%), and Germany (5.82%).

Conclusion

Despite considerable advances in the quality of both clinical and laboratory research, only six level I studies were identified. Osteonecrosis/bisphosphonates and platelet-rich plasma were frequent topics indicating the recent interests in these fields. The USA has continued to play a major role in the research; however, there needs to be more international, multi-institutional cooperative collaborations.

http://ift.tt/2lQecQa

Antiandrogenic drugs, a therapeutic option for frontal fibrosing alopecia patients

http://ift.tt/2hDJzsI