T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

Abstract

T-cell/histiocyte-rich large B-cell lymphoma (THRBCL) is an uncommon subtype of non-Hodgkin's lymphoma. It is a predominant nodal neoplasm; however, extranodal sites, such as the spleen, liver and bone marrow, can be involved at diagnosis. However, only one case of primary THRLBCL in the jaws have been reported. We herein describe a 29-year-old female patient who presented with a swelling of the right mandible that had grown rapidly over the previous 2 months. Periapical and panoramic radiographs showed a multilocular osteolytic lesion located in the mandibular periapical region of the canine and premolar teeth and molar region. Preoperative examination and incisional biopsy were performed. Immunohistochemistry was applied to confirm the diagnosis of THRBCL in the jaw. The treatment consisted of CHOP therapy and radiotherapy. After complete tumor remission following initial treatment, additional sites of the disease appeared in the lung, abdomen and long bones. The patient died within 2 months. THRLBCL is an uncommon and aggressive malignant neoplasm that can involve the jaws, mimicking a periapical disease.

https://ift.tt/2zM2kWz

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

Abstract

T-cell/histiocyte-rich large B-cell lymphoma (THRBCL) is an uncommon subtype of non-Hodgkin's lymphoma. It is a predominant nodal neoplasm; however, extranodal sites, such as the spleen, liver and bone marrow, can be involved at diagnosis. However, only one case of primary THRLBCL in the jaws have been reported. We herein describe a 29-year-old female patient who presented with a swelling of the right mandible that had grown rapidly over the previous 2 months. Periapical and panoramic radiographs showed a multilocular osteolytic lesion located in the mandibular periapical region of the canine and premolar teeth and molar region. Preoperative examination and incisional biopsy were performed. Immunohistochemistry was applied to confirm the diagnosis of THRBCL in the jaw. The treatment consisted of CHOP therapy and radiotherapy. After complete tumor remission following initial treatment, additional sites of the disease appeared in the lung, abdomen and long bones. The patient died within 2 months. THRLBCL is an uncommon and aggressive malignant neoplasm that can involve the jaws, mimicking a periapical disease.

https://ift.tt/2zM2kWz

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

Abstract

T-cell/histiocyte-rich large B-cell lymphoma (THRBCL) is an uncommon subtype of non-Hodgkin's lymphoma. It is a predominant nodal neoplasm; however, extranodal sites, such as the spleen, liver and bone marrow, can be involved at diagnosis. However, only one case of primary THRLBCL in the jaws have been reported. We herein describe a 29-year-old female patient who presented with a swelling of the right mandible that had grown rapidly over the previous 2 months. Periapical and panoramic radiographs showed a multilocular osteolytic lesion located in the mandibular periapical region of the canine and premolar teeth and molar region. Preoperative examination and incisional biopsy were performed. Immunohistochemistry was applied to confirm the diagnosis of THRBCL in the jaw. The treatment consisted of CHOP therapy and radiotherapy. After complete tumor remission following initial treatment, additional sites of the disease appeared in the lung, abdomen and long bones. The patient died within 2 months. THRLBCL is an uncommon and aggressive malignant neoplasm that can involve the jaws, mimicking a periapical disease.

https://ift.tt/2zM2kWz

The subtleties of stress: A comparative analysis of skeletal lesions between the medieval and post‐medieval black friars cemetery population (13th To 17th Centuries)

International Journal of Osteoarchaeology, Volume 0, Issue ja, -Not available-.


https://ift.tt/2L1wJW4

Diagnostik und Therapie von Tränenwegserkrankungen

Zusammenfassung

Hintergrund

Leitsymptom einer Tränenabflussstörung ist die Epiphora. Der Leidensdruck der Patenten durch das permanent tränende Auge ist sehr hoch.

Ziel der Arbeit

Es wird ein strukturierter Überblick über die gängigen diagnostischen und therapeutischen Optionen gegeben.

Material und Methoden

Die wichtigsten diagnostischen und therapeutischen Ansätze werden anhand der aktuellen Literatur und eigenen Erfahrungen beleuchtet.

Ergebnisse

Die Anamnese ist wichtigster Schlüssel zur Diagnose. Durch Inspektion und Palpation der Lid- und Tränensackregion kann der Verdacht auf eine Tränenabflussstörung erhärtet werden. Hierbei sind Untersuchungen der Tränenproduktion, der Qualität der Tränen und der Beschaffenheit der Augenoberfläche hilfreich. Als wichtigste diagnostische Maßnahme ist die Sondierung und Spülung der ableitenden Tränenwege (TNW) bedeutsam. Die Therapie richtet sich nach der zugrunde liegenden Pathologie. Die Behandlung der konnatalen Dakryostenose folgt einem strukturierten Stufenkonzept. Eine Epiphora im Erwachsenenalter ohne Zeichen einer Dakryozystitis kann zumeist durch transkanalikuläre Operationstechniken behandelt werden. Im Fall einer chronischen Dakryozystitis kommt neben der Dakryoendoskopie die Dakryozystorhinostomie in Betracht. Verletzungen der TNW erfordern eine zeitnahe Sanierung unter Einsatz von TNW-Intubationstechniken. TNW-Tumoren sind histologisch zu klassifizieren, um eine gezielte Therapie im Rahmen eines interdisziplinären Managements zu ermöglichen.

Schlussfolgerung

Die ophthalmologische Basisdiagnostik wird durch Spezialuntersuchungen befundabhängig ergänzt. Die stetige Weiterentwicklung vorhandener diagnostischer und therapeutischer Optionen ermöglicht eine zunehmend individualisierte Behandlung der Patienten.

https://ift.tt/2L1wp9O

Transoral Robotic Surgery for Oropharyngeal Cancer

Transoral robotic surgery has shown significant promise in the management of oropharyngeal cancer since its description in 2007. The oncological efficacy of this procedure has been proven in several single-centre studies, multicentre collaborative publications and systematic reviews. The rapid take-up of transoral robotic surgery shows greater acceptance by professionals and is associated with a relatively short learning curve. This overview discusses the rationale and principles underlying the use of transoral robotic surgery in primary and recurrent oropharyngeal cancer and the emerging role for this technique in diagnosing the unknown primary site, and summarizes ongoing research in this field.
ORL

https://ift.tt/2uEUmst

Effects of family environment features on cochlear-implanted children

Abstract

Purpose

The role of cochlear implant in deaf children development is well-known. However, the results are highly variable and depend on several factors. The most important role belongs to the family, family environment in which the child develops. The aim of the study was to evaluate the features of the family environment in which cochlear-implanted children develop.

Methods

The questionnaire "Family Environment Scale" was sent to 108 families who had cochlear-implanted child with more than 6 months of experience. One of the parents was asked to fill out the questionnaire which also included general information about the child and the family.

Results

A total of 58 families responded to the questionnaire and accepted to participate in the study. Mean values were higher compared with normal families in the areas of cohesion, expressiveness, intellectual-cultural orientation and organization, but the cohesion and organization score mean value exceeded the normal values (between 40 and 60). The independence and the conflict areas had lower values than normal families but did not exceed the lower limit of normal (40).

Conclusions

The relationship between the family and the auditory-verbal development potential of the cochlear-implanted child is obvious. However, further studies are needed to establish correlations between the characteristics of the family environment and the level of auditory-verbal and psycho-cognitive development of the cochlear-implanted child so we can act on the family environment through education or therapy, to get maximum benefit with these children.

https://ift.tt/2Lhl9oU