Allergic Contact Dermatitis Evaluation: Strategies for the Preschooler

Abstract

Purpose of Review

The environment for the developing children is complex as they are exposed to a variety of activities and settings where potential environmental allergens may be encountered. Recent evidence supports the clinical benefit of patch testing young children suffering from recalcitrant dermatitis. While patch testing has been recently approved by the Food and Drug Administration in children ages 6–18 years old, patch testing strategies for young children of preschool age (between 2 and 6 years old) have yet to be defined.

Recent Findings

Allergic contact dermatitis is underdiagnosed among pediatric patients, particularly those suffering from concomitant atopic dermatitis as the interplay between the two diseases is complex. Recent reports in literature supported the clinical value, safety, and efficacy of patch testing pediatric patients.

Summary

This review provides an overview of specific pediatric allergens, special considerations, practical modifications, and systematic exposure-driven guidance approaches toward patch testing preschoolers.

https://ift.tt/2n0fAxx

Periodontitis may modulate long-non coding RNA expression

Publication date: Available online 1 August 2018

Source: Archives of Oral Biology

Author(s): Fausto Sánchez-Muñoz, Gustavo Martínez-Coronilla, Ana Gabriela Leija-Montoya, Ulises Rieke-Campoy, Rosa Angelina Lopez-Carrasco, María de Lourdes Montaño-Pérez, Ernesto Beltrán-Partida, Yolanda Bojórquez-Anaya, Nicolas Serafin-Higuera, Javier González-Ramírez

Abstract

Periodontitis is a chronic inflammatory disease that compromises the integrity of the periodontium. Despite extensive research involving periodontitis, the detailed mechanisms underlying periodontal inflammation remain unclear. However, new important expression regulators have been emerging, such as non-coding RNAs, which are important determinants in the molecular control of the inflammatory process. Taking into consideration the vital role of non-coding RNAs, we determined for the first time the expression profiles of different long non-coding RNAs (lncRNAs) that are implicated in inflammation. In this study, we take periodontal samples of healthy subjects, patients with gingivitis and with periodontitis. In both disease groups, the lncRNA OIP5-AS1 expression levels were lower than levels in healthy subjects (P < 0.05). This study reveals new insights into the relative levels of OIP5-AS1 lncRNA in healthy, gingivitis and periodontal tissue, which may have important applications as a potential biomarker with protagonist activity in the development and manifestation of destructive periodontitis.

https://ift.tt/2Oxq3wQ

Long-Term Therapy with Corticosteroids in Nasal Polyposis: A Bone Metabolism Assessment

Abstract

Chronic rhinosinusitis associated with nasal polyposis (RSCwNP) affects 4% of the general population. As chronic condition, it requires chronic pharmacological treatment, whereas the surgical approach becomes necessary in obstructive and/or complicated cases. Intranasal and systemic corticosteroids (CS) represent the "Gold Standard" treatment for RSCwNP. The present study aimed to evaluate the side effects of prednisone in a group of patients with RSCwNP treated with long-term CS. In particular, attention was focused on bone disorders (osteopenia and osteoporosis) and prospective fracture risk increase. Forty patients (26 females, mean age 55.70 ± 14.03 years) affected by RSCwNP have been enrolled. Control group included 40 healthy subjects (17 females, mean age 56.37 ± 13.03 years). Nasal endoscopy, skin prick tests, nasal cytology, and bone densitometry were evaluated in all subjects. The likelihood of impaired bone metabolism (osteopenia or osteoporosis) was superimposable in both groups. Within RSCwNP group, no parameter was statistically significant in predicting a metabolism alteration.

https://ift.tt/2n08nxl

Periodontitis may modulate long-non coding RNA expression

Publication date: Available online 1 August 2018

Source: Archives of Oral Biology

Author(s): Fausto Sánchez-Muñoz, Gustavo Martínez-Coronilla, Ana Gabriela Leija-Montoya, Ulises Rieke-Campoy, Rosa Angelina Lopez-Carrasco, María de Lourdes Montaño-Pérez, Ernesto Beltrán-Partida, Yolanda Bojórquez-Anaya, Nicolas Serafin-Higuera, Javier González-Ramírez

Abstract

Periodontitis is a chronic inflammatory disease that compromises the integrity of the periodontium. Despite extensive research involving periodontitis, the detailed mechanisms underlying periodontal inflammation remain unclear. However, new important expression regulators have been emerging, such as non-coding RNAs, which are important determinants in the molecular control of the inflammatory process. Taking into consideration the vital role of non-coding RNAs, we determined for the first time the expression profiles of different long non-coding RNAs (lncRNAs) that are implicated in inflammation. In this study, we take periodontal samples of healthy subjects, patients with gingivitis and with periodontitis. In both disease groups, the lncRNA OIP5-AS1 expression levels were lower than levels in healthy subjects (P < 0.05). This study reveals new insights into the relative levels of OIP5-AS1 lncRNA in healthy, gingivitis and periodontal tissue, which may have important applications as a potential biomarker with protagonist activity in the development and manifestation of destructive periodontitis.

https://ift.tt/2Oxq3wQ

FIMARAD : la filière de santé maladies rares en dermatologie

Publication date: Available online 31 July 2018

Source: Annales de Dermatologie et de Vénéréologie

Author(s): C. Bodemer, C. Taïeb, D. Vidaud, S. Ingen-Housz-Orob, R. Gène

https://ift.tt/2OwCI3b

Assessing severity of anaphylaxis: a data-driven comparison of 23 instruments

The severity of an allergic reaction can range from mild local symptoms to anaphylactic shock. To score this, a number of instruments have been developed, although heterogeneous in design and purpose. Severity...

https://ift.tt/2mYwuMS

Case report: Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine

Abstract

A 62-year-old woman who underwent surgery to treat pancreatic cancer provided written, informed consent to undergo adjuvant therapy with gemcitabine, tegafur, and uracil. However, this was stopped after only 14 days due to Grade 4 neutropenia. She was then started on vaccine therapy with Survivin 2B peptide (SVN-2B) including IFA and INF-α. Although metastatic lung tumors were identified and resected at 82 months after surgery, the patient has remained free of new or relapsed disease for 12 years thereafter. Tetramer and ELISPOT assays revealed the continuous circulation of SVN-2B-restricted cytotoxic T-lymphocytes (CTLs) in her peripheral blood, and CTL clones had specific activity for SVN-2B at 12 years after surgery. The adverse effects of the peptide vaccination were tolerable and comprised low-grade headache, nausea, and fatigue. A prognosis beyond 10 years in the face of pancreatic cancer with distant metastasis is extremely rare. This experience might indicate the value of cancer vaccination therapy.

https://ift.tt/2Kf8yyj