Primeras experiencias con el dispositivo osteointegrado Ponto™ SuperPower

Publication date: Available online 17 December 2018

Source: Acta Otorrinolaringológica Española

Author(s): Tomás Pérez-Carbonell, Ignacio Pla-Gil, Antonio Morant-Ventura, Emilia Latorre-Monteagudo, M. Ignacia Pitarch-Ribas, Jaime Marco-Algarra

Resumen

Los dispositivos auditivos osteointegrados (DAO) Power y SuperPower presentan indicaciones para umbrales en vía ósea de 55 y 65 dB, respectivamente.

Realizamos un estudio observacional prospectivo de una serie de 6 casos con hipoacusia mixta en los que se realizó implantación del DAO Ponto™ SuperPower.

Se realizaron previo a la implantación y 6 meses tras la adaptación valoraciones tonales y verbales sin y con ruido de fondo (HINTS).

Todos los participantes mostraron mejoría en los resultados tonales y verbales, variando según el grado de hipoacusia contralateral. Cabe destacar los resultados verbales con ruido de fondo donde la mayoría de los pacientes obtuvieron una relación señal ruido entre 2 y 4 dB. Los resultados en los cuestionarios APHAB y GBI mostraron una reducción de la percepción del problema y una mejoría en la calidad de vida, respectivamente. Los resultados presentados reflejan la posibilidad de tratamiento de hipoacusias mixtas con el dispositivo DAO Ponto™ SuperPower.

Abstract

Osseointegrated hearing devices Power and SuperPower present indications for bone thresholds of 55 and 65 dB respectively.

We conducted a prospective observational study of a series of six cases with mixed hearing loss for whom implantation of the DAO Ponto™ Super-Power was performed.

Tonal and verbal evaluations without and with background noise (HINTS) were performed prior to implantation and six months after adaptation.

All the participants showed improvement in tonal and verbal results, varying according to the degree of contralateral hearing loss. The verbal results with background noise were noteworthy, where most of the patients obtained a signal-to-noise ratio between 2 and 4 dB. The results in the APHAB and GBI questionnaires showed a reduction in the perception of the problem and an improvement in quality of life respectively. The results presented reflect the possibility of treatment of mixed hearing loss with the Ponto™ SuperPower device.

https://ift.tt/2S9BaNV

Predictive value of the number of adverse reaction episodes for the IgE-mediated food allergy diagnosis

Publication date: Available online 17 December 2018

Source: Allergologia et Immunopathologia

Author(s): S. Miceli Sopo, G. Gurnari, S. Monaco, A. Romano, L. Liotti, B. Cuomo, I. Dello Iacono, L. Badina, G. Longo, M. Calvani, A. Giannone, C. Calabrò, G. Scala, M.C. Verga

Abstract

Introduction and objectives

The reproducibility of the adverse reaction increases the suggestiveness of a history of food allergy. However, the positive predictive value (PPV) of multiple adverse reaction episodes for the diagnosis of IgE-mediated food allergy is not known. This evaluation was the objective of our study.

Patients and methods

We retrospectively studied 180 children with a history of non-anaphylactic adverse reactions after the ingestion of a food. All children had the prick test positive for the offending food and performed the oral food challenge (OFC) within 12 months after the last adverse reaction episode (ARE). We have evaluated whether increasing the number of ARE increased the probability that the OFC would be positive (failed).

Results

93 patients (52%) presented one ARE, 49 (27%) presented two ARE, 24 (13%) presented three ARE, 14 (8%) patients presented ≥ four ARE. The OFC was positive in 94/180 (52%). The outcome of the OFC was found to be positively correlated with the number of ARE (OR = 1.56; 95% CI = 1.16–2.09; p = 0.003). A PPV = 100% was observed with a number of ARE ≥ five.

Conclusions

The number of ARE is an important predictor of the diagnosis of food allergy, although less than we would have imagined. The number of ARE could be used to increase the predictability of the diagnostic tests currently in use, to define clinical prediction rules alternative to OFC and easy to use in clinical practice.

https://ift.tt/2GzG6dY

Preterm birth is associated with higher prevalence of wheeze and asthma in a selected population of Japanese children aged three years

Publication date: Available online 17 December 2018

Source: Allergologia et Immunopathologia

Author(s): N. Takata, K. Tanaka, C. Nagata, M. Arakawa, Y. Miyake

Abstract

Background

The present cross-sectional study investigated the associations between low birthweight (LBW), high birthweight, preterm birth (PTB), postterm birth, small for gestational age (SGA), and large for gestational age (LGA) and the prevalence of wheeze and asthma in Japanese children aged three years (age range, 33–54 months; mean age, 38.7 months).

Methods

Study subjects were 6364 children. A questionnaire was used to collect all data. Wheeze and asthma were defined according to the criteria of the International Study of Asthma and Allergies in Childhood.

Results

The prevalence values of wheeze and asthma were 19.5% and 7.7%, respectively. Of the 6364 subjects, 8.8% were classified as LBW (<2500 g), 90.4% as normal birthweight, 0.8% as high birthweight (≥4000 g), 4.8% as PTB (<37 weeks), 94.8% as term birth, 0.4% as postterm birth (≥42 weeks), 7.8% as SGA (<10th percentile), 82.5% as appropriate for gestational age, and 9.7% as LGA (>90th percentile). Compared with term birth, PTB was independently positively associated with wheeze and asthma: the adjusted ORs (95% CI) were 1.47 (1.11–1.92) and 1.52 (1.02–2.20), respectively. An independent positive association was shown between PTB and wheeze only in boys; the interaction between PTB and sex was significant. Such an interaction between PTB and sex was not seen for asthma. No evident associations were observed between LBW, high birthweight, postterm birth, SGA, or LGA and wheeze or asthma.

Conclusions

This is the first study in Japan to show that PTB, but not LBW or SGA, was significantly positively associated with childhood wheeze and asthma.

https://ift.tt/2R4aiSh

Yogurt is tolerated by the majority of children with IgE-mediated cow's milk allergy

Publication date: Available online 17 December 2018

Source: Allergologia et Immunopathologia

Author(s): S. Monaco, G. Russo, A. Romano, L. Liotti, M.C. Verga, S. Miceli Sopo

Abstract

Background

Children with IgE-mediated cow's milk allergy (IgE-CMA) with gastrointestinal symptoms tolerate yogurt at 100%. Yogurt tolerance in children with IgE-CMA with urticaria and anaphylaxis was 7%.

Methods

We enrolled children with IgE-CMA with cutaneous, respiratory, gastrointestinal and anaphylactic symptoms. All performed prick by prick (PbP) and oral food challenge (OFC) with yogurt. Some children performed also an OFC with CM mixed with wheat flour and baked, baked liquid CM, parmesan.

Results

34 children were enrolled, 31/34 (91%) with systemic adverse reaction after ingestion of CM (systemic CMA), 3/34 (9%) with isolated contact urticaria (ICU CMA). PbP with yogurt was negative only in one patient. OFC with yogurt was passed (that is, the OFC was negative) by 20/31 (64%) of the children with systemic CMA. 10/11 (91%) of the patients who failed OFC (that is, the OFC was positive) with yogurt were positive to SPT with casein vs. 8/20 (40%) of the patients who passed it (p = 0.018). None of the 19 children who passed OFC with yogurt failed all OFC with processed CM forms other than yogurt that tested vs. 4/8 among those who failed OFC with yogurt (p = 0.006). The rub test with yogurt was negative in 1/3 (33%) of the patients with ICU CMA.

Conclusions

The results of our study are placed alongside others already present in the literature and concerning other methods of processing CM proteins and help to reduce the dietary restrictions of the majority of children with systemic IgE-CMA.

https://ift.tt/2Gnokdt

The microbiome and oral cancer: More questions than answers

Publication date: February 2019

Source: Oral Oncology, Volume 89

Author(s): Claire M. Healy, Gary P. Moran

Abstract

Recent advances in DNA sequencing technology have facilitated rapid advances in the analysis of the human microbiome and its role in human disease. Several studies have now shown that OSCC and some oral premalignant conditions are associated with alterations in the oral microbiome. These studies raise questions regarding the role of the oral microbiome in the progression of oral malignancies and whether microbiome change is a significant risk factor in the development of oral cancer. This short review summarises current knowledge in the field and highlights questions that require further investigation.

https://ift.tt/2EAj4lb

Free flaps in head and neck reconstruction in patients affected by vasculitis: To risk or not to risk?

Publication date: Available online 17 December 2018

Source: Oral Oncology

Author(s): Andrea Battisti, Valeria Bracciolini, Valentina Terenzi, Andrea Cassoni, Maria Teresa Fadda, Valentino Valentini

https://ift.tt/2EtAU8s

Cripto 1, a potential biomarker for oral squamous cell carcinoma

Publication date: Available online 17 December 2018

Source: Oral Oncology

Author(s): Anu Jain, Sumanth Mallupattu, Reetu Thakur, Sushmita Ghoshal, Arnab Pal

https://ift.tt/2EBpj8r