Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Δευτέρα 8 Ιουλίου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,

S100 Negative CD1a Positive Indeterminate Cell Histiocytosis, Sima Amin BS  Jordan Jamerson MD  Ronald...
S100 Negative CD1a Positive Indeterminate Cell Histiocytosis,Sima Amin BS  Jordan Jamerson MD  Ronald G. Tee MD  Palak Parekh MDFirst published: 06 July 2019 https://doi.org/10.1111/cup.13542This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cup.13542.ePDFPDFTOOLS...
Αλέξανδρος Γ. Σφακιανάκης
2m
Number of levels required to assess Breslow thickness in cutaneous invasive melanoma: An Observational...
Number of levels required to assess Breslow thickness in cutaneous invasive melanoma: An Observational StudyDr Jamie Bishop MBChB  Dr Ben Tallon MBChBFirst published: 03 July 2019 https://doi.org/10.1111/cup.13541This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cup.13541.ePDFPDFTOOLS...
Αλέξανδρος Γ. Σφακιανάκης
3m
An atypical pleomorphic lipomatous tumor arising on the cheek Alan S. Boyd M.D First published: 02...
An atypical pleomorphic lipomatous tumor arising on the cheekAlan S. Boyd M.DFirst published: 02 July 2019 https://doi.org/10.1111/cup.13540This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cup.13540.ePDFPDFTOOLS SHAREAbstractPathologists and dermatopathologists...
Αλέξανδρος Γ. Σφακιανάκης
3m
Malignant Melanoma with Metastatic Cartilaginous Transdifferentiation, a Case Report Juliett Berro ...
Malignant Melanoma with Metastatic Cartilaginous Transdifferentiation, a Case ReportJuliett Berro  Nour Abdul Halim  Chirine Khaled  Hazem I. AssiFirst published: 01 July 2019 https://doi.org/10.1111/cup.13539This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/cup.13539.ePDFPDFTOOLS...
Αλέξανδρος Γ. Σφακιανάκης
4m
Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern Simon F. Roy ...
Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction patternSimon F. Roy  Christine J. Ko  Gilbert W. Moeckel  Jennifer M. McniffFirst published: 03 June 2019 https://doi.org/10.1111/cup.13522Funding information ASDP, Grant/Award Number: Mentorship Award to Simon F. RoyRead the full textePDFPDFTOOLS SHAREAbstractBackgroundHypergranulotic dyscornification (HD) is a rarely reported histological reaction pattern that may be observed in solitary benign keratoses.Objective and...
Αλέξανδρος Γ. Σφακιανάκης
4m
The morphologic spectrum of germline‐mutated BAP1‐inactivated melanocytic tumors includes lesions with...
The morphologic spectrum of germline‐mutated BAP1‐inactivated melanocytic tumors includes lesions with conventional nevic melanocytes: A case report and review of literatureTimothy R. Wysozan  Sihem Khelifa  Kirsten Turchan  Ahmed K. AlomariFirst published: 17 June 2019 https://doi.org/10.1111/cup.13525Read the full textePDFPDFTOOLS SHAREAbstractGermline mutations in BRCA1‐associated protein 1 (BAP1) are associated with several neoplasms, including BAP1‐inactivated melanocytic tumors (BIMTs). BIMTs...
Αλέξανδρος Γ. Σφακιανάκης
4m
Plasmacytic cutaneous pathology: A review Noreen M. Walsh  Heinz Kutzner  Luis Requena  Lorenzo...
Plasmacytic cutaneous pathology: A reviewNoreen M. Walsh Heinz Kutzner Luis Requena Lorenzo CerroniFirst published: 16 May 2019https://doi.org/10.1111/cup.13499We review the spectrum of cutaneous disorders associated with inflammatory and neoplastic plasmacytic pathology. Because plasma cells are derived from B‐lymphocytes our overview includes discussion of certain lymphoplasmacytic proliferations. It is structured along histopathological lines, addressing conditions characterized by (a) cutaneous...
Αλέξανδρος Γ. Σφακιανάκης
4m
Primary cutaneous acral CD8+ T‐cell lymphoma of the ear: A case report Emma Ormerod  Timothy Murigu ...
Primary cutaneous acral CD8+ T‐cell lymphoma of the ear: A case reportEmma Ormerod  Timothy Murigu  Joya Pawade  Matthew Beasley  Giles DunnillFirst published: 30 May 2019 https://doi.org/10.1111/cup.13517Read the full textePDFPDFTOOLS SHAREAbstractPrimary cutaneous acral CD8+ T‐cell lymphoma (TCL) is a rare, distinct type of cutaneous TCL. Despite its worrisome histological appearance it has a benign clinical course. It is therefore important to recognize this as a distinct entity from other more...
Αλέξανδρος Γ. Σφακιανάκης
5m
Pain
Non-specific Low Back Pain: Inflammatory Profiles of Patients with Acute and Chronic PainBackground: The pathogenesis of low back pain (LBP) remains unclear. However, recent studies suggest that the inflammatory response may be inherent in spinal pain. Purpose: To discern inflammatory profiles in patients with non-specific acute and chronic low back pain (LBP) in relation to those in asymptomatic subjects. Methods: Peripheral blood samples were obtained from asymptomatic subjects and patients with...
Αλέξανδρος Γ. Σφακιανάκης
6m
Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation:...
Primary cutaneous biphasic sarcomatoid basal cell carcinoma with myoepithelial carcinoma differentiation: a new variant,Claudia Mestre‐Alagarda  Gema Nieto  Liria Terrádez  Carlos MonteagudoFirst published: 06 July 2019 https://doi.org/10.1111/cup.13543This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record....
Αλέξανδρος Γ. Σφακιανάκης
6m
Ethics and Professionalism Grand Rounds— Tuesday, July 23, 2019Against-Medical-Advice Discharges: What...
Ethics and ProfessionalismGrand Rounds—Tuesday, July 23, 2019Against-Medical-Advice Discharges: What They Can Teach us About Respecting Patient Rights and Preventing Patient HarmIn this live webinar, VHA healthcare professionals will learn how to manage ethical issues related to against-medical-advice, or "AMA" discharges.  Dr. David Alfandre and Dr. Virginia (Ashby) Sharpe of the National Center for Ethics in Health Care will discuss using a patient-centered approach to shared-decision making as...
Αλέξανδρος Γ. Σφακιανάκης
8m
Unfortunate Hand Positioning Yielding Inappropriate Defibrillator Shock: Another Paradigm of...
Unfortunate Hand Positioning Yielding Inappropriate Defibrillator Shock: Another Paradigm of a Guilty Association Between Patient Awareness and Occupational HazardAntoine KossaifyFirst Published July 1, 2019 Case Report https://doi.org/10.1177/1179547619861096Article information   Article InformationVolume: 12Article first published online: July 1, 2019; Issue published: January 1, 2019Received: May 12, 2019; Accepted: June 03, 2019 Antoine Kossaify1, 21Cardiology Division, Arrhythmia Unit, Holy...
Αλέξανδρος Γ. Σφακιανάκης
9m
Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn's Disease: A Case Report...
Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn's Disease: A Case ReportShow all authorsKanika Goel, Mark Bunker, Anna Balog, ...First Published July 3, 2019 Case Report https://doi.org/10.1177/1179547619858979Article information   Article InformationVolume: 12Article first published online: July 3, 2019; Issue published: January 1, 2019Received: May 10, 2019; Accepted: May 29, 2019 Kanika Goel, Mark Bunker, Anna Balog, Jan F SilvermanDepartment of Pathology, Allegheny General...
Αλέξανδρος Γ. Σφακιανάκης
10m
Mandibular Tori Limiting Treatment of Carcinoma of the Upper Aerodigestive Tract Christopher...
Mandibular Tori Limiting Treatment of Carcinoma of the Upper Aerodigestive TractChristopher M Low, Daniel L Price, Jan L KasperbauerFirst Published July 3, 2019 Case Report https://doi.org/10.1177/1179547619856599Article information   Article InformationVolume: 12Article first published online: July 3, 2019; Issue published: January 1, 2019Received: May 14, 2019; Accepted: May 20, 2019Christopher M Low, Daniel L Price, Jan L KasperbauerDepartment of Otolaryngology–Head and Neck Surgery, Mayo Clinic,...
Αλέξανδρος Γ. Σφακιανάκης
10m
Traumatic Lesion of the Brachial Artery in a Pediatric Patient: Treatment With Bioresorbable...
Traumatic Lesion of the Brachial Artery in a Pediatric Patient: Treatment With Bioresorbable Vascular ScaffoldShow all authorsFrancesca Tomei, Raffaella Berchiolli, Rosa Cervelli, ...First Published July 4, 2019 Case Report https://doi.org/10.1177/1179547619857074Article information   Article InformationVolume: 12Article first published online: July 4, 2019; Issue published: January 1, 2019Received: April 13, 2019; Accepted: May 22, 2019Francesca Tomei1, Raffaella Berchiolli1, Rosa Cervelli2, Irene...
Αλέξανδρος Γ. Σφακιανάκης
11m
Differences of FreeStyle Libre Flash Glucose Monitoring System and Finger Pricks on Clinical...
Differences of FreeStyle Libre Flash Glucose Monitoring System and Finger Pricks on Clinical Characteristics and Glucose Monitoring Satisfactions in Type 1 Diabetes Using Insulin PumpAyman A Al Hayek, Asirvatham A Robert, Mohamed A Al DawishFirst Published July 1, 2019 Research Article https://doi.org/10.1177/1179551419861102Article information   Article InformationVolume: 12Article first published online: July 1, 2019; Issue published: January 1, 2019Received: May 19, 2019; Accepted: June 07, 2019Ayman...
Αλέξανδρος Γ. Σφακιανάκης
12m
Management of an Unusual Intranasal Foreign Body Abutting the Cribriform Plate: A Case Report...
Management of an Unusual Intranasal Foreign Body Abutting the Cribriform Plate: A Case Report and Review of LiteratureMingyang L Gray, Catharine Kappauf, Satish GovindarajFirst Published July 1, 2019 Research Article https://doi.org/10.1177/1179550619858606Article information   Article InformationVolume: 12Article first published online: July 1, 2019; Issue published: January 1, 2019Received: May 16, 2019; Accepted: May 21, 2019 Mingyang L Gray,  Catharine Kappauf, Satish GovindarajDepartment of...
Αλέξανδρος Γ. Σφακιανάκης
12m
The Potential of Chinese Herbal Medicines in the Treatment of Cervical Cancer Show less...
The Potential of Chinese Herbal Medicines in the Treatment of Cervical CancerShow lessYi-Hsuan Hsiao, MD, PhD, Chiao-Wen Lin, PhD, Po-Hui Wang, MD, PhD, Min-Chien Hsin, PhD, Shun-Fa Yang, PhDFirst Published July 4, 2019 Review Article https://doi.org/10.1177/1534735419861693Article information   Article InformationVolume: 18Article first published online: July 4, 2019; Issue published: January 1, 2019Received: March 18, 2019; Revisions received: April 30, 2019; Accepted: June 03, 2019Yi-Hsuan Hsiao, MD,...
Αλέξανδρος Γ. Σφακιανάκης
13m
Regional Lymph Node Enlargement in Clinically Severe Cherubism Show less Yan Chen Wongworawat*, Daniel...
Regional Lymph Node Enlargement in Clinically Severe CherubismShow lessYan Chen Wongworawat*, Daniel Jack*, Jared C Inman, Fouad Abdelhalim, Camilla Cobb, Craig William Zuppan, Anwar RazaFirst Published July 4, 2019 Case Report https://doi.org/10.1177/2632010X19861107Article information   Article InformationVolume: 12Article first published online: July 4, 2019; Issue published: January 1, 2019 Yan Chen Wongworawat1*, Daniel Jack1*, Jared C Inman2, Fouad Abdelhalim3, Camilla Cobb1, Craig William...
Αλέξανδρος Γ. Σφακιανάκης
15m
Monostotic Fibrous Dysplasia of the Lumbar Spine With Secondary Features of Solid Variant Aneurysmal...
Monostotic Fibrous Dysplasia of the Lumbar Spine With Secondary Features of Solid Variant Aneurysmal Bone Cyst,Nolan Maloney and Konstantinos LinosAbstractFibrous dysplasia is a benign, mass-forming disease of bone composed of abnormal fibrous and osseous elements that can be accompanied by endocrine dysfunction, skin pigmentation, and intramuscular myxomas. It is usually encountered as a solitary lesion in the tibia or femur but can develop in any bone and can be unifocal or multifocal. Difficulty...
Αλέξανδρος Γ. Σφακιανάκης
17m
The combined effect of tranilast 8% liposomal gel on the final cosmesis of acne scarring in patients concomitantly treated by isotretinoin
: Prospective double blind split‐face studyA. Weinstein, A. Koren, E. Sprecher, E. Zur, J.N. Mehrabi, Ofir Artzi
Αλέξανδρος Γ. Σφακιανάκης
18m
British Association of Dermatologists (BAD) National Audit on Non‐Melanoma Skin Cancer Excision 2016...
British Association of Dermatologists (BAD) National Audit on Non‐Melanoma Skin Cancer Excision 2016 in collaboration with the Royal College of Pathologists,D. J. Keith, A. P. Bray, A. Brain, M. F. Mohd Mustapa, H. E. Barrett, S. Lane, M. Emmerich, A. Jakes, P. D. Barrett, D. A. R. de Berker
Αλέξανδρος Γ. Σφακιανάκης
19m
Should non‐selective non‐steroidal anti‐inflammatory drugs (NSAIDs) be avoided following dermatologic surgery?
 A critically appraised topic with a proposed approach to post‐operative analgesiaT. Watson Brown, S. Nelson, T. Nelson
Αλέξανδρος Γ. Σφακιανάκης
19m
Wheat‐dependent Exercise‐induced Anaphylaxis
 in Chinese People:A Clinical Research on 33 Cases with Antigenic Analysis of Wheat ProteinsY.‐q. Zhu, D.‐q. Wang, B. Liu, Y. Hu, Y.‐y. Shen, J.‐h. Xu, H. Tang
Αλέξανδρος Γ. Σφακιανάκης
19m
Abnormal expression of the co‐stimulatory molecule B7‐H3 in lichen simplex chronicus is associated with...
Abnormal expression of the co‐stimulatory molecule B7‐H3 in lichen simplex chronicus is associated with expansion of Langerhans cells,X. Feng, M. Yang, Z. Yang, Q. Qian, E. M. Burns, W. Min
Αλέξανδρος Γ. Σφακιανάκης
20m
Male genital lichen sclerosus and filaggrin,T. N. Shim, S. J. Brown, N. D. Francis, M. Dinneen, D. Hawkins, A....
Male genital lichen sclerosus and filaggrin,T. N. Shim, S. J. Brown, N. D. Francis, M. Dinneen, D. Hawkins, A. Muneer, S. Minhas, W. H. Irwin McLean, C. B. Bunker
Αλέξανδρος Γ. Σφακιανάκης
20m
Latin American Clinical Practice Guidelines on the Systemic Treatment of Psoriasis SOLAPSO – Sociedad...
Latin American Clinical Practice Guidelines on the Systemic Treatment of Psoriasis SOLAPSO – Sociedad Latinoamericana de Psoriasis (Latin American Psoriasis Society),Nora Kogan, Nélida Raimondo, Simon E. Gusis, Ariel Izcovich, Jorge A. Abarca Duran, Lilia Barahona‐Torres, Orestes Blanco, Gerardo B. Quintana, María C. Briones, Carla Castro, Evelyn G. Castro Vargas, Juan Criniti, Juan C. Diez de Medina, Manuel Franco, Minerva Gómez, Verónica P. Levrero, Jaime E. Martínez López, Fernando Valenzuela
Αλέξανδρος Γ. Σφακιανάκης
21m
Comparison of naproxen and Gelofen for Pain relief in lower third molar surgery
: A single-blinded randomized clinical trialEhsan Aliabadi, Saeid Tavanafar, Mehdi HayatiEuropean Journal of General Dentistry 2019 8(2):41-44Objectives: Third molar surgeries are a routine procedure in oral and maxillofacial surgery and its associated pain is bothersome to patients. The purpose of this study was to compare the analgesic effect of Gelofen and naproxen in lower third molar surgery. Materials and Methods: A single-blinded randomized clinical trial was designed, and patients were randomly...
Αλέξανδρος Γ. Σφακιανάκης
22m
General Dentistry
Treatment and prevention of oral mucositis: A literature reviewParas Ahmad, Usman Akhtar, Ahmed Chaudhry, Usman Rashid, Sarmad Saif, Jawaad Ahmed AsifEuropean Journal of General Dentistry 2019 8(2):23-28Oral health is a cardinal element of nutritional as well as systemic well-being and plays a substantial part in sustaining optimum general health condition. Various factors influence oral health including metabolic diseases such as endocrine, hematological, gastrointestinal, cutaneous, and neurological...
Αλέξανδρος Γ. Σφακιανάκης
23m
Treatment and prevention of oral mucositis
: A literature reviewParas Ahmad, Usman Akhtar, Ahmed Chaudhry, Usman Rashid, Sarmad Saif, Jawaad Ahmed AsifEuropean Journal of General Dentistry 2019 8(2):23-28Oral health is a cardinal element of nutritional as well as systemic well-being and plays a substantial part in sustaining optimum general health condition. Various factors influence oral health including metabolic diseases such as endocrine, hematological, gastrointestinal, cutaneous, and neurological diseases. The intent of this review...
Αλέξανδρος Γ. Σφακιανάκης
23m
Polydioxanone sheet as a rigid framework in skull‐base repair
: Our experience in thirteen patientsMohd Afiq Mohd Slim  Hussain Jasem  Louise Melia  Gerald McGarryFirst published: 19 June 2019 https://doi.org/10.1111/coa.13391Read the full textPDFTOOLS SHARE
Αλέξανδρος Γ. Σφακιανάκης
24m
The use of freeze‐dried retronasal stimuli to assess olfactory functionPooja Pal, Daniel Shepherd, Nazimah...
The use of freeze‐dried retronasal stimuli to assess olfactory functionPooja Pal, Daniel Shepherd, Nazimah Hamid, Michael J. HautusAbstractObjectivesTo evaluate a test of olfactory perception that uses freeze‐dried stimuli developed to rapidly release aromas capable of migrating to the olfactory mucosa retronasally.DesignValidation study.SettingPsychology and Chemistry Departments.ParticipantsFirst, 15 participants provided data for psychometric functions. Second, 70 participants made perceptual...
Αλέξανδρος Γ. Σφακιανάκης
25m
Preoperative electrophysiological analysis predicts preservation of hearing and facial nerve function following vestibular schwannoma surgery with continuous intraoperative neural monitoring
: clinical outcomes of twenty‐two casesMakoto Hosoya, Naoki Oishi, Takanori Nishiyama, Masaru Noguchi, Kento Kasuya, Noriomi Suzuki, Hidemi Miyazaki, Kaoru OgawaPreoperative electrophysiological analysis predicts preservation of hearing and facial nerve function following vestibular schwannoma surgery with reinforced continuous intraoperative monitoring.Setting the lower limit of the monitoring target amplitude in accordance with preoperative ENoG was associated with the preservation of facial nerve...
Αλέξανδρος Γ. Σφακιανάκης
25m
Transoral laser microsurgery using high‐flow nasal cannula oxygenation
: Our experience of 21 casesSusanne Flach, Azza Elhoweris, Samit Majumdar, Simon Crawley, Jaiganesh ManickavasagamAbstractOptimal access and visualisation is crucial during TLM, however, airway management can be challenging.Oxygenation via HFNC provides a safe and effective way for airway management during tubeless field anaesthesia in TLM.HFNC oxygenation during TLM is well tolerated and avoids risks associated with other methods of tubeless field anaesthesia.HFNC oxygenation during TLM should only...
Αλέξανδρος Γ. Σφακιανάκης
26m
Carbohydrate Availability as a Regulator of Energy Balance with Exercise We explore the novel hypothesis...
Carbohydrate Availability as a Regulator of Energy Balance with ExerciseWe explore the novel hypothesis that carbohydrate availability is involved in the regulation of energy balance with exercise, via hormonal and neural signals. We propose that carbohydrate availability could play a direct mechanistic role and partially explain previously-documented relationships between a more active lifestyle and tighter control of energy balance. Corresponding author: Javier T. Gonzalez, Department for Health,...
Αλέξανδρος Γ. Σφακιανάκης
27m
Transcallosal Control of Bilateral Actions The corpus callosum is an important neural structure for...
Transcallosal Control of Bilateral ActionsThe corpus callosum is an important neural structure for controlling and coordinating bilateral movements of the upper limbs; however, there remains a substantial lack of knowledge regarding its association with lower limb control. We argue that transcallosal structure is an integral neural mechanism underlying control of the lower limbs and callosal degradation is a key contributor to mobility declines. Corresponding Author: Brett W. Fling, Ph.D., Assistant...
Αλέξανδρος Γ. Σφακιανάκης
27m
Rapid-Onset Psychotic Symptoms After Interferon-β-1a Treatment of Multiple Sclerosis Huang, Jing-Syuan...
Rapid-Onset Psychotic Symptoms After Interferon-β-1a Treatment of Multiple SclerosisHuang, Jing-Syuan MD1,2; Chang, Chuan-Chia MD, PhD2; Tai, Yueh-Ming MD, PhD1,2; Huang, Chien-Peng MD3; Chen, Shyi-Jou MD, PhD4; Tzeng, Nian-Sheng MD2,5American Journal of Therapeutics: June 19, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/MJT.0000000000001017Letters to the Editor: PDF OnlyBUYPAPAuthor InformationArticle MetricsCopyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Αλέξανδρος Γ. Σφακιανάκης
28m
Pembrolizumab for PD-L1–Positive Breast Cancer Refractory to Chemotherapy Phan, Kim DO; Charif, Mahmoud...
Pembrolizumab for PD-L1–Positive Breast Cancer Refractory to ChemotherapyPhan, Kim DO; Charif, Mahmoud MDAmerican Journal of Therapeutics: June 18, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/MJT.0000000000001015Letters to the Editor: PDF OnlyBUYPAPAuthor InformationArticle MetricsCopyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Αλέξανδρος Γ. Σφακιανάκης
29m
Trametinib is a cancer drug. It is a MEK inhibitor drug with anti-cancer activity. It inhibits MEK1 and MEK2. Trametinib had good results for metastatic melanoma carrying the BRAF V600E mutation in a phase III clinical trial.
Trametinib-Associated BradycardiaAlhazmi, Luai MD1; Karim, Mohammad M. MD2; Al-Sarie, Mohammad MD3; Skeel, Roland MD4; Karim, Saima DO1American Journal of Therapeutics: June 20, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/MJT.0000000000000862Letters to the Editor: PDF OnlyBUYPAPAuthor InformationArticle MetricsCopyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Αλέξανδρος Γ. Σφακιανάκης
29m
Adalimumab, sold under the brand name Humira among others, is a medication used to treat rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, psoriasis, hidradenitis suppurativa, uveitis, and juvenile idiopathic arthritis.
Adalimumab-Associated Hemorrhagic PericarditisVyas, Rohit MD1; Adeel, Firas A. MD1; Sheikh, Taha MD1; Syed, Mubbasher MD1,2; Altorok, Nezam MD1,3American Journal of Therapeutics: June 21, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/MJT.0000000000001019Letters to the Editor: PDF OnlyBUYPAPAuthor InformationArticle MetricsCopyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Αλέξανδρος Γ. Σφακιανάκης
30m
Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical Trial...
Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical TrialBackground: Effect of nifedipine on pressure ulcer (PU) healing has not been evaluated in the human subjects yet. Study question: In this study, the effect of topical application of nifedipine 3% ointment on PU healing in critically ill patients was investigated. Study design: This was a randomized, double-blind, placebo-controlled clinical. Measures and outcomes: In this study, 200 patients with...
Αλέξανδρος Γ. Σφακιανάκης
32m
Turmeric-Associated Liver Injury, Turmeric is a flowering plant, Curcuma longa of the ginger family,...
Turmeric-Associated Liver Injury,Turmeric is a flowering plant, Curcuma longa of the ginger family, Zingiberaceae, the roots of which are used in cooking.Abdallah, Mohamed A. MD1; Abdalla, Abdelmohaymin MD1; Ellithi, Moataz MD1; Abdalla, Abubaker O. MD2; Cunningham, Arwyn G. DO3; Yeddi, Ahmed MD4; Rajendiran, Govarthanan MD5American Journal of Therapeutics: June 28, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/MJT.0000000000001025
Αλέξανδρος Γ. Σφακιανάκης
32m
Exercise and Sport Sciences
Amplified Neural Plasticity and Strength After StrokeFollowing stroke, sensorimotor brain networks and descending regulation are compromised but spinal interlimb neural connections remain morphologically intact. After cross-education strength and locomotion training, amplified neural plasticity and functional responses are observed in chronic stroke compared to neurologically intact participants. We hypothesize that post-stroke neuroplasticity is amplified because of the involvement of interlimb...
Αλέξανδρος Γ. Σφακιανάκης
33m
Propofol Infusion and Acute Pancreatitis: A ReviewBackground: Propofol is a short-acting anesthetic...
Propofol Infusion and Acute Pancreatitis: A ReviewBackground: Propofol is a short-acting anesthetic used to induce sedation in various ambulatory and inpatient surgical procedures. It is a US Food and Drug Administration approved lipid-based intravenous hypnotic agent, which has been used clinically for the induction and maintenance of anesthesia for over 3 decades. In addition to general anesthesia, it is used to sedate patients undergoing mechanical ventilation or short procedures such as endoscopy,...
Αλέξανδρος Γ. Σφακιανάκης
34m
Therapeutics
Propofol Infusion and Acute Pancreatitis: A ReviewBackground: Propofol is a short-acting anesthetic used to induce sedation in various ambulatory and inpatient surgical procedures. It is a US Food and Drug Administration approved lipid-based intravenous hypnotic agent, which has been used clinically for the induction and maintenance of anesthesia for over 3 decades. In addition to general anesthesia, it is used to sedate patients undergoing mechanical ventilation or short procedures such as endoscopy,...
Αλέξανδρος Γ. Σφακιανάκης
34m

General Dentistry

Treatment and prevention of oral mucositis: A literature review
Paras Ahmad, Usman Akhtar, Ahmed Chaudhry, Usman Rashid, Sarmad Saif, Jawaad Ahmed Asif

European Journal of General Dentistry 2019 8(2):23-28

Oral health is a cardinal element of nutritional as well as systemic well-being and plays a substantial part in sustaining optimum general health condition. Various factors influence oral health including metabolic diseases such as endocrine, hematological, gastrointestinal, cutaneous, and neurological diseases. The intent of this review is to highlight the treatment as well as prevention strategies for one of the most devastating repercussions of chemotherapy (CT) and radiotherapy (RT) on the oral cavity in the form of oral mucositis (OM). A review of literature was performed using relevant key words (”Mucositis” OR “Oral Mucositis” OR “Oral Stomatitis” AND “Treatment of Mucositis” OR “Treatment of Oral Mucositis” OR “Treatment of Oral Stomatitis” AND “Prevention of Mucositis” OR “Prevention of Oral Mucositis” OR “Prevention of Oral Stomatitis”) in prominent journals pertaining to Oncology and Dentistry (CA: A Cancer Journal for Clinicians, Cancer, Frontiers in Oncology, Journal of Clinical Oncology, and Oral Oncology). It is basically sequelae of CT, RT, and radiochemotherapy in patients suffering from malignant diseases as well as those who require hematopoietic stem cell transplants. In addition to its negative effects on the oral cavity and consequently on the overall quality of life, OM may lead to delay in cancer treatment which incriminates in a poor prognosis of the disease. 


Effect of liner on the marginal integrity of resin composite restorations after selective caries excavation: An In Vitro study
Shailaja Datta, Baranya Shrikrishna Suprabha, Ethel Suman, Ramya Shenoy, Arathi Rao, KP Nandita

European Journal of General Dentistry 2019 8(2):29-35

Aim: The aim of this study is to evaluate the effect of cavity liner on marginal adaptation and microleakage of resin composite restorations placed with and without selective caries excavation. Materials and Methods: Class II cavities were prepared in 64 extracted upper premolar teeth followed by microbiological caries induction to simulate deep carious lesions. Composite restorations were performed: Group 1A: without liner and Group 1B: with resin-modified glass ionomer liner after nonselective caries excavation; Group 2A: without liner and Group 2B: with resin-modified glass ionomer liner after selective caries excavation. Maximum gap thickness was measured using a scanning electron microscope to assess the marginal adaptation, and dye penetration method was used for microleakage assessment. Results: There was a statistically significant difference between the groups in maximum gap thickness based on the type of caries excavation (P < 0.001) but not for the placement of liner. Selective caries excavation groups had higher values at all margins. Microleakage between the groups was significantly different, both at the occlusal (P = 0.006) and gingival margins (P < 0.001), with Groups 2A and 2B showing higher microleakage. Conclusion: Resin composite restorations performed after selective caries excavation showed decreased marginal integrity and liner application did not contribute to any significant improvement in the same. 


Bulk-fill versus conventional composite: A comparative analysis on degree of conversion
Fernanda Ferreira de Albuquerque Jasse, Hélida Gomes de Oliveira Barud, Juliana Maria Capelozza Boaventura, Cristiane de Melo Alencar, Alexandre Gatti, Edson Alves de Campos

European Journal of General Dentistry 2019 8(2):36-40

Aim: This study aimed to determine the degree of conversion (DC) of two resin-based composites: a conventional nanohybrid composite and a bulk-fill flowable composite (SureFil® SDR™ flow). Materials and Methods: DC was evaluated at 1-, 2-, 3-, and 4-mm depths at varying irradiation times (20 and 40 s) by Fourier-transform infrared spectroscopy. Disc-shaped specimens of varying depths were prepared and photoactivated with a third-generation light-emitting diode light-curing unit. The specimens were stored for 24 h in the dark at ambient temperature and pulverized into a fine powder which was mixed with potassium bromide. After homogenization, the mixture pressed to form a pellet. All pellets were evaluated by an infrared spectrometer equipped with a triglycine sulfate detector using diffuse reflectance. The percentage of monomer conversion was determined from the ratio of the absorbance intensities of the aliphatic carbon–carbon double bonds (C = C) and the internal standard before and after the curing of the composite, represented by the aromatic carbon–carbon single bonds (C-C). Results: The DC data for the bulk-fill resin showed no significant difference (P > 0.05) for different irradiation depths, whereas for the conventional nanohybrid resins, statistical analyses revealed a significant result of the variables time and depth as well as the interaction between them. Conclusions: The results indicated that SDR™ achieves a 4-mm depth of cure with both 20- and 40-s light exposures. 


Comparison of naproxen and Gelofen for Pain relief in lower third molar surgery: A single-blinded randomized clinical trial
Ehsan Aliabadi, Saeid Tavanafar, Mehdi Hayati

European Journal of General Dentistry 2019 8(2):41-44

Objectives: Third molar surgeries are a routine procedure in oral and maxillofacial surgery and its associated pain is bothersome to patients. The purpose of this study was to compare the analgesic effect of Gelofen and naproxen in lower third molar surgery. Materials and Methods: A single-blinded randomized clinical trial was designed, and patients were randomly allocated into four groups (n = 20 cases in each group): pre-Gelofen group: 400 mg Gelofen 30 min preoperative and continuing every 6 h, Gelofen group: 400 mg Gelofen immediately postoperative and continuing every 6 h, pre-naproxen group: 500 mg naproxen 30 min preoperative and every 8 h, and naproxen group: 500 mg naproxen immediately postoperative and every 8 h. The pain intensity was recorded using the visual analog scale at 2, 6, 12, and 24 h after surgery. Results: Pain intensity decreased in a linear pattern in all groups after 2, 6, 12, and 24 h. In pre-naproxen group, pain decreased suddenly between 2 and 6 h, but after 6 h, pain relief was slower than other groups. The mean pain intensity at 2 h postoperative for the pre-naproxen group was significantly lower than Gelofen group, and at 6 h, it was less than all other groups. At 12 and 24 h after surgery, pain intensity in all groups was similar except for the Gelofen group. Conclusion: Under limitation of the present study, preoperative intake of naproxen showed more effective pain relief than other groups. 


Comparison of miller's classification of gingival recession defects with mahajan's classification of gingival recession defect: A reliability study
Ajay Mahajan, Kanwarjit Singh Asi, Deepa Rayast, Mayum Negi

European Journal of General Dentistry 2019 8(2):45-50

Background: Gingival recession is a common periodontal problem encountered in most populations. A number of classification systems are available to classify gingival recession defects (GRDs), but there has been a lack of consensus among the clinicians regarding the choice of classification system to classify GRDs. Recently, Miller's classification has been criticized owing to its inherent limitations. Mahajan's classification was proposed to eliminate the drawbacks of Miller's classification system. To the best of our knowledge, there has been no study testing or comparing the reliability of Miller's classification; therefore, the present study was done to compare the reliability of Miller's classification with Mahajan's classification. Materials and Methods: The sites selected for the study were classified for GRD according to either Miller's classification or Mahajan's classification by the two groups of four examiners. All the examiners were calibrated for the two classification systems and classified the selected sites accordingly. Kappa statistics was performed to analyze the intra- and interrater agreement among the four examiners. Results: A total of 609 gingival recession sites in 91 patients (49 males and 42 females) were classified. At the end of the study, Mahajan's classification had a higher intrarater (κ = 0.93–0.83) and interrater reliability (κ = 0.93) compared to Miller's classification for GRD for both intrarater (κ = 0.57–0.68) and interrater observations (κ = 0.66), respectively. Conclusions: Miller's classification system was less reliable than Mahajan's classification system. 


Pulp canal calcification associated with periapical lesion as dental trauma sequelae – Clinical-surgical treatment
Michelle Zardin Furich, Cristina Braga Xavier, Luis Eduardo Rilling Nova Cruz, Josu&#233 Martos

European Journal of General Dentistry 2019 8(2):51-54

The objective of this report is to describe a surgical treatment in a traumatized tooth presenting pulp canal calcification (PCC) and periapical pathology. Three months after a patient had suffered injuries by luxation in the right central mandibular incisor, complete calcification of root canals was radiographically observed in addition to a radiographic image compatible with apical periodontitis. The chosen treatment was endodontic surgery and apical root sealing with mineral trioxide aggregate endodontic cement. After 4 months, the tooth showed complete apical repair. We concluded that the endodontic surgery is a procedure specifically indicated for cases of impossibility of conventional endodontic treatment, as in teeth with PCC. 


Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Exercise and Sport Sciences

Amplified Neural Plasticity and Strength After Stroke
Following stroke, sensorimotor brain networks and descending regulation are compromised but spinal interlimb neural connections remain morphologically intact. After cross-education strength and locomotion training, amplified neural plasticity and functional responses are observed in chronic stroke compared to neurologically intact participants. We hypothesize that post-stroke neuroplasticity is amplified because of the involvement of interlimb neural connections that persist from our quadrupedal ancestry. Corresponding Author: E. Paul Zehr, Rehabilitation Neuroscience Laboratory, PO Box 3010 STN CSC, University of Victoria, Victoria, BC Canada, V8W 3P1, pzehr@uvic.ca; 1-250-721-8379 Acknowledgments: This research was supported by funding to Dr. E. Paul Zehr from the Heart and Stroke Foundation (British Columbia and Yukon) and the Natural Sciences and Engineering Research Council (NSERC) of Canada. Declaration of Interest: The authors declare that they have no conflict of interest regarding the publication of this paper. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. © 2019 American College of Sports Medicine

Transcallosal Control of Bilateral Actions
The corpus callosum is an important neural structure for controlling and coordinating bilateral movements of the upper limbs; however, there remains a substantial lack of knowledge regarding its association with lower limb control. We argue that transcallosal structure is an integral neural mechanism underlying control of the lower limbs and callosal degradation is a key contributor to mobility declines. Corresponding Author: Brett W. Fling, Ph.D., Assistant Professor – Health and Exercise Science Department, Assistant Professor – Molecular, Cellular & Integrative Neurosciences Program, Colorado State University, (970) 491-3451; Brett.Fling@colostate.edu Disclosure of funding: This work was supported in part by funding from a National Multiple Sclerosis Society Pilot Research Grant (PP-1708-29077) and a David Mahoney Neuroimaging Grant from the Dana Foundation. Conflict of interest: The authors have no conflicts to report. © 2019 American College of Sports Medicine

Macrophage Regulation of Muscle Regrowth from Disuse in Aging
Skeletal muscle immune cells, such as macrophages, are necessary for proper regrowth following muscle disuse. We suggest that the important role of macrophages concerning muscle regrowth following disuse is divergent compared to young mice (i.e. dysregulated) during the recovery period. Modulation of macrophages may be a promising future therapeutic target to enhance the impaired muscle growth during recovery from disuse in older adults. Corresponding author: M. J. Drummond, University of Utah, Department of Physical Therapy and Athletic Training, 520 Wakara Way, Salt Lake City, UT 84108-1213, USA. Email: micah.drummond@hsc.utah.edu Funding: This work was supported by the National Institute of Aging (R01AG050781, R21AG042699), the National Center for Complementary and Integrative Health (R01AT009268) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (F32AR072481). Authors declare no conflict of interest © 2019 American College of Sports Medicine

Perspectives for Progress - Female Athlete Triad and Relative Energy Deficiency in Sport: A Focus on Scientific Rigor
We examine the scientific evidence supporting The Female Athlete Triad and Relative Energy in Sport (RED-S) syndromes. More research is necessary to advance the understanding of both syndromes; however, it is premature to consider RED-S as an evidence-based syndrome. Future research should specifically define RED-S components, determine its clinical relevance, and establish the causality of relative energy deficiency on RED-S outcomes. Address for Correspondence: Nancy I. Williams, Sc.D., FACSM, FNAK, Professor and Head, Department of Kinesiology, Co-Director, Women's Health and Exercise Laboratory, The Pennsylvania State University, 276 Recreation Building, University Park, PA 16802. Email: niw1@psu.edu; Phone: 814-863-1163 Conflicts of interest; disclosure of funding: none © 2019 American College of Sports Medicine

Carbohydrate Availability as a Regulator of Energy Balance with Exercise
We explore the novel hypothesis that carbohydrate availability is involved in the regulation of energy balance with exercise, via hormonal and neural signals. We propose that carbohydrate availability could play a direct mechanistic role and partially explain previously-documented relationships between a more active lifestyle and tighter control of energy balance. Corresponding author: Javier T. Gonzalez, Department for Health, University of Bath, BA2 7AY, United Kingdom. Tel: 0(+44) 1225 38 5518; E-mail: J.T.Gonzalez@bath.ac.uk, ORCID ID: 0000-0002-9939-0074. Funding: No funding was received for the preparation of this manuscript. Conflicts of interest: J.T.G. has received research funding and/or has acted as a consultant for Arla Foods Ingredients, Lucozade Ribena Suntory, Kenniscentrum Suiker and Voeding, and PepsiCo. J.A.B. has received research funding and/or has acted as a consultant for GlaxoSmithKline, Lucozade Ribena Suntory, Kellogg's, Nestlé and PepsiCo and is a scientific advisor to the International Life Sciences Institute (ILSI). D.T. has received funding and acted as a consultant for Unilever. © 2019 American College of Sports Medicine

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Therapeutics

Propofol Infusion and Acute Pancreatitis: A Review
Background: Propofol is a short-acting anesthetic used to induce sedation in various ambulatory and inpatient surgical procedures. It is a US Food and Drug Administration approved lipid-based intravenous hypnotic agent, which has been used clinically for the induction and maintenance of anesthesia for over 3 decades. In addition to general anesthesia, it is used to sedate patients undergoing mechanical ventilation or short procedures such as endoscopy, transesophageal echocardiogram, and abscess drainage. An infrequent but serious complication of propofol is acute pancreatitis (AP), with potentially significant morbidity and possible mortality. In this review, we will discuss the proposed mechanisms of AP secondary to propofol, a number of reported cases, studies conducted, and treatment strategies. Areas of Uncertainty: There are several case reports in the literature that have shown an association between propofol and pancreatitis. The exact mechanism behind propofol-induced pancreatitis is not fully understood, but proposed mechanisms include hypertriglyceridemia (HTG), hypersensitivity, or direct pancreatic toxicity of the drug. Although the association of propofol and pancreatitis has not been proven conclusively, clinicians should be aware of this possible rare complication to prevent the devastating consequences of AP. Data Sources: We gathered articles on previously documented case reports and up-to-date studies on propofol-induced pancreatitis by searching databases such as PubMed and Google Scholar. Results: Based on previous studies and case reports, we suggest that propofol should be added to a list of drugs having a direct association with AP. Conclusions: Although, the mechanism of propofol-induced pancreatitis is not fully understood, and the causal relationship of propofol-induced hypertriglyceridemia or idiosyncratic drug reaction has remained unproven. Clinicians should be aware of the association between propofol and pancreatitis, and any patient presenting with abdominal pain after propofol infusion should be evaluated for AP and treated promptly to avoid complications. Address for correspondence: Post-Doctoral Research Fellow, Department of Surgery, Langone Medical Center, New York University, NYU Langone Health, Science Building, 435 E. 30th St, 4th Floor, New York, NY 10016. E-mail: usmanjutt898@gmail.com The authors have no conflicts of interest to declare. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Turmeric-Associated Liver Injury
No abstract available

Antimicrobial and Antineoplastic Properties of Sertraline
No abstract available

Topical Nifedipine for the Treatment of Pressure Ulcer: A Randomized, Placebo-Controlled Clinical Trial
Background: Effect of nifedipine on pressure ulcer (PU) healing has not been evaluated in the human subjects yet. Study question: In this study, the effect of topical application of nifedipine 3% ointment on PU healing in critically ill patients was investigated. Study design: This was a randomized, double-blind, placebo-controlled clinical. Measures and outcomes: In this study, 200 patients with stage I or II PU according to 2-digit Stirling Pressure Ulcer Severity Scale were randomized to receive topical nifedipine 3% ointment or placebo twice daily for 14 days. Changes in the size and stage of the ulcers were considered as primary outcome of the study. The stage of the ulcers at baseline and on day 7 and day 14 of study was determined by using 2-digit stirling scale. In addition, the surface area of the wounds was estimated by multiplying width by length. Results: In total, 83 patients in each group completed the study. The groups were matched for the baseline stage and size of PUs. Mean decrease in the stage of PU in the nifedipine group was significantly higher than the placebo group on day 7 (−1.71 vs. −0.16, respectively, P < 0.001) and day 14 (−0.78 vs. −0.09, respectively, P < 0.001). Furthermore, the mean decrease in the surface area of PU was significantly higher in the nifedipine group compared with the placebo group on day 7 (−1.44 vs. −0.32, respectively, P < 0.001) and day 14 (−2.51 vs. −0.24, respectively, P < 0.001) of study. Conclusions: Topical application of nifedipine 3% ointment for 14 days significantly improved the healing process of stage I or II PUs in critically ill patients. Address for correspondence: Professor of Clinical Pharmacy, Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran, Postal Code: 14176-14411, P O Box: 14155/6451. E-mail: Khalilih@sina.tums.ac.ir The authors have no conflicts of interest to declare. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.

Adalimumab-Associated Hemorrhagic Pericarditis
No abstract available

Role of Flumazenil in the Management of Hepatic Encephalopathy
No abstract available

Trametinib-Associated Bradycardia
No abstract available

Poor Response to Alirocumab in a Patient With Homozygous Familial Hypercholesterolemia
No abstract available

Rapid-Onset Psychotic Symptoms After Interferon-β-1a Treatment of Multiple Sclerosis
No abstract available

Pembrolizumab for PD-L1–Positive Breast Cancer Refractory to Chemotherapy
No abstract available

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480