Influence of Sex and Age on Ratings of Confidence and Relevance in Continuing Certification Longitudinal Assessment – A Pilot Study

alexandrossfakianakis shared this article with you from Inoreader Influence of Sex and Age on Ratings of Confidence and Relevance in Continuing Certification Longitudinal Assessment – A Pilot Study Via American Journal of Physical Medicine & Rehabilitation - Published Ahead-of-Print Objective Longitudinal assessments use spaced repetition of items to facilitate learning. Algorithms selecting repetition items can prioritize various properties for future presentation. The purpose of this pilot study is to evaluate the relationship between participant ratings of item-specific confidence and/or practice relevance and participant age, sex, and response correctness. Design Prospective quality improvement study of 403 American Board of Physical Medicine and Rehabilitation (ABPMR) diplomates with time-limited certificates. Participants answered 20 items quarterly over four quarters, rating each item on its relevance to their practice and their confidence in their response. Results The relationship between sex and ratings of response confidence was significant, with women less likely than men to be confident in their responses, regardless of correctness. Younger physicians were significantly more confident in their responses and rated items as more practice relevant. Conclusion Women physicians were less confident than men in their item-specific confidence ratings, regardless of correctness, on the ABPMR continuing certification longitudinal knowledge assessment. Older physicians were less confident in their responses than younger physicians. The findings supported the ABPMR prioritization of response correctness and practice relevance, rather than response confidence, to select items for spaced repetition in ABPMR's continuing certification longitudinal assessment. Disclosure: employed by the American Board of Physical Medicine and Rehabilitation Mikaela M. Raddatz, PhD, American Board of Physical Medicine and Rehabilitation, Rochester, Minnesota. Disclosure: employed by the American Board of Physical Medicine and Rehabilitation Lawrence R. Robinson, MD, Division of Physical Medicine and Rehabilitation, University of Toronto, Toronto, Ontario, Canada. Disclosure: no disclosures No funding was received for this study. Corresponding author: Carolyn L. Kinney, MD, American Board of Physical Medicine and Rehabilitation, 3015 Allegro Park Ln SW, Rochester, MN 55902. Phone : 502-282-1776, Extension 1743. Email : ckinney@abpmr.org. Fax: 507-282-9242 Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

How does the measurement of disability in low back pain map unto the International Classification of Functioning, Disability and Health (ICF)? A scoping review of the manual medicine literature

alexandrossfakianakis shared this article with you from Inoreader How does the measurement of disability in low back pain map unto the International Classification of Functioning, Disability and Health (ICF)? A scoping review of the manual medicine literature Via American Journal of Physical Medicine & Rehabilitation - Published Ahead-of-Print The objective of this study was to catalogue items from instruments used to measure functioning, disability, and contextual factors in patients with low back pain (LBP) treated with manual medicine (manipulation and mobilization) according to the International Classification of Functioning, Disability and Health (ICF). This catalogue will be used to inform the development of an ICF-based assessment schedule for LBP patients treated with manual medicine. In this scoping review we systematically searched MEDLINE, Embase, PsycINFO and CINAHL. We identified instruments (questionnaires, clinical tests, single questions) used to measure functioning, disability and contextual factors, extracted the relevant items and then linked these items to the ICF. We included 95 articles and identified 1510 meaningful concepts. All but 70 items were linked to the ICF. Of the concepts linked to the ICF, body functions accounted for 34.7%, body structures accounted for 0%, activities and participation accounted for 41%, environmental factors accounted for 3.6%, and personal factors accounted for 16%. Most items used to measure functioning and disability in LBP patient treated with manual medicine focus on body functions, and activities and participation. The lack of measures that address environmental factors warrants further investigation. Corresponding author: Pierre Côté, UOIT-CMCC Centre for Disability Prevention and Rehabilitation, University of Ontario Institute of Technology, Oshawa, Canada. Pierre.Cote@uoit.ca The project received funding from: The European Centre for Chiropractic Research Excellence (ECCRE), Contract No. 19-2017-NO-EA And ELiB – et liv i bevegelse, Oslo, Norway, Reference No. 234068-2500 Richard Nicol has a financial relationship with ELIB, as a consultant. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Developing a Framework for Designing and Deploying Technology-Assisted Rehabilitation Post Stroke: A Qualitative Study

alexandrossfakianakis shared this article with you from Inoreader Developing a Framework for Designing and Deploying Technology-Assisted Rehabilitation Post Stroke: A Qualitative Study Via American Journal of Physical Medicine & Rehabilitation - Published Ahead-of-Print Objective Many unmet rehabilitation needs of patients with stroke can be addressed effectively using technology. However, technological solutions have not yet been seamlessly incorporated into clinical care. The purpose of this pilot study was to examine how to bridge the gaps between the recovery process, technology, and clinical practice to impact stroke rehabilitation meaningfully. Design Semi-structured interviews using a grounded theory approach with purposive sampling of 17 diverse expert providers in acute care, inpatient, and outpatient stroke rehabilitation settings. Common themes were identified from qualitative analyses of the transcribed conversations to develop a guiding framework from the emerging concepts. Results Four core themes emerged that addressed major barriers in stroke rehabilitation and technology-assisted solutions to overcome these barriers: 1) accessibility to quality rehabilitation, 2) adaptability to patient differences, 3) accountability or compliance with rehabilitation, and 4) engagement with rehabilitation. Conclusion The results suggest a four-pronged framework, the A3E framework which stands for Accessibility, Adaptability, Accountability and Engagement, to comprehensively address existing barriers in providing rehabilitation services. This framework can guide technology developers and clinicians in designing and deploying technology-assisted rehabilitation solutions for post-stroke rehabilitation, particularly using tele-rehabilitation. Corresponding author: Preeti Raghavan, MD, Address: 600 North Wolfe Street, Phipps Bldng. Suite 182, Baltimore, MD 21287. Phone number: 410-955-0703. Email: praghav3@jhmi.edu Acknowledgement of Funding: This work is supported in part by the National Science Foundation grants DRK-12 DRL: 1417769, ITEST DRL: 1614085, and RET Site EEC: 1542286; and NY Space Grant Consortium grant 76156-10488. Conflict(s)-of-Interest/Disclosure(s): All authors have completed the ICMJE uniform disclosure and declare no support from any organization for the submitted work; VK and PR have an issued patent on Game-based Sensorimotor Rehabilitator; PR reports consulting for Mirrored Motion Works, Inc., outside the submitted work. No other relationships or activities appear to have influenced the submitted work. Anna Palumbo is in training. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Circular RNA circTP63 enhances estrogen receptor-positive breast cancer progression and malignant behaviors through the miR-873-3p/FOXM1 axis

alexandrossfakianakis shared this article with you from Inoreader Circular RNA circTP63 enhances estrogen receptor-positive breast cancer progression and malignant behaviors through the miR-873-3p/FOXM1 axis Via Anti-Cancer Drugs - Published Ahead-of-Print Circular RNAs (circRNAs) have been shown to play a functional role in a variety of cancers. However, few studies on circRNAs in estrogen receptor-positive breast cancer have been conducted. Here, we investigated the role of circRNA circTP63 in estrogen receptor-positive breast cancer progression and malignant behaviors. First, we observed increased expression of circTP63 in MCF7 cells relative to normal human mammary epithelial cell lines, such as DU4475 and MCF-10A, and the changed oncogenicity of MCF7 cells correlated with circTP63 overexpression and downregulation. Interestingly, a series of gain- and loss-of-function assays revealed that a higher level of FOXM1 was closely associated with MCF7 malignant behaviors induced by circTP63 overexpression. Further investigations showed that c ircTP63 sponged to miR-873-3p, which targeted FOXM1 mRNA and inhibited its expression. Mechanistically, circTP63 binds to miR-873-3p and prevents the targeting of FOXM1, thus inducing the progression and malignant behaviors of estrogen receptor-positive breast cancer, such as cell proliferation, cell cycle dysregulation, invasion, migration and even tumor growth. CircTP63 might be a potential biomarker or target to treat estrogen receptor-positive breast cancer patients in the future. Received 2 July 2020 Revised form accepted 25 September 2020 Supplemental Digital Content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website, www.anti-cancerdrugs.com. Correspondence to Yue-e Xu, Department of Thyroid and Breast Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, 62 Huaihai Road(S), Huai'an 223002, China, Tel: +86 15195387009; e-mail: yueexu1206@163.com Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

S-allylcysteine induces cytotoxic effects in two human lung cancer cell lines via induction of oxidative damage, downregulation of Nrf2 and NF-κB, and apoptosis

alexandrossfakianakis shared this article with you from Inoreader S-allylcysteine induces cytotoxic effects in two human lung cancer cell lines via induction of oxidative damage, downregulation of Nrf2 and NF-κB, and apoptosis Via Anti-Cancer Drugs - Published Ahead-of-Print In this study, we investigated the putative cytotoxic effect elicited by the garlic-derived compound S-allylcysteine (SAC) in two human cancer cell lines (HCC827 and NCI-H1975) in order to develop an experimental approach to the therapeutic potential of this molecule for lung cancer. Cells were incubated for 24, 48 and 72 h in the presence of SAC (10 or 20 mM), which resulted in a concentration- and time-dependent decrease in cell viability and culture confluence in both cell lines. These effects were contrasted with – and validated through – those observed in an immortalized but nontumorigenic epithelial cell line from human bronchial epithelium (BEAS-2B, negative control) and an adenocarcinoma human alveolar basal epithelial cell line (A549, positive control). SAC (20� �mM at 72 h) also increased the oxidative damage to lipids, augmented apoptosis, and decreased the expression of the nuclear factor erythroid 2-related factor 2 (Nrf2) and the nuclear factor kappa B (NF-κB) proteins in HCC827 and NCI-H1975 cells. Our results establish the efficacy of SAC in reducing malignant growth and proliferation of lung tumor cells. This effect is mediated by the induction of oxidative damage associated with the downregulation of Nrf2 and NF-κB and their corresponding signaling pathways. Received 26 August 2020 Revised form accepted 4 October 2020 Correspondence to Ana Laura Colín-González, PhD, Banco de Tumores, Instituto Nacional de Cancerología, S.S.A., Av. San Fernando # 22, Tlalpan, CDMX 14080, México, Tel: +5255 5628 0400 (x18113); e-mail: laura_coling@yahoo.com.mx Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cryptochrome 1 is modulated by blue light in human keratinocytes and exerts positive impact on human hair growth

alexandrossfakianakis shared this article with you from Inoreader Cryptochrome 1 is modulated by blue light in human keratinocytes and exerts positive impact on human hair growth Via Wiley: Experimental Dermatology: Table of Contents Abstract Photoactivation of cryptochrome‐family proteins by blue light is a well‐established reaction regulating physiology of plants, fungi, bacteria, insects and birds, while impact of blue light on cryptochrome synthesis and/or activity in human non‐visual cells remains unknown. Here, we show that 453 nm blue light induces cryptochrome 1 (CRY1) accumulation in human keratinocytes and the hair follicle. CRY1 is prominently expressed in the human anagen hair follicle, including epithelial stem cells. Specific silencing of CRY1 promotes catagen, while stimulation of CRY1 by KL001 prolongs anagen ex vivo by altering the expression of genes involved in apoptosis and proliferation. Together, our study identifies a role for CRY1 in sustaining human hair growth. Previously we demonstrated positive effects of 453 nm blue light on hair growth ex vivo. Taken all together, our study suggests that CRY1 might mediate blue light dependent positive effects on hair growth. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Overexpression of Fgf8 in the epidermis inhibits hair follicle development

alexandrossfakianakis shared this article with you from Inoreader Overexpression of Fgf8 in the epidermis inhibits hair follicle development Via Wiley: Experimental Dermatology: Table of Contents Abstract The hair follicle is a classical model for studying epithelial‐mesenchymal interactions. Given the critical role of fibroblast growth factor 8 (Fgf8) in embryonic development, we generated a mouse model that overexpresses Fgf8 specifically in the epidermis. Interestingly, these mutant mice exhibited stunted, smaller bodies and severe hypotrichosis. Histological analysis showed that the hair follicles in the mutants were arrested at stage 2 of hair development. The density of hair follicles in the mutant mice was also lower compared to that in the control mice. Overexpression of Fgf8 inhibited the proliferation of epidermal cells and simultaneously promoted apoptosis, leading to the arrest of hair follicle development. Further analysis showed that sonic hedgehog (Shh) and bone morphogenetic protein 4 (Bmp4) were downregulated and upregulated, respectively. To summarize, our study demonstrates that FGF signaling plays an important role in the regulation of hair folli cle development. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.