Repair of a severe palm injury with anterolateral thigh and ilioinguinal flaps: A case report.

paythelady.612 shared this article with you from Inoreader Repair of a severe palm injury with anterolateral thigh and ilioinguinal flaps: A case report. Μέσω pubmed: "world j clin cases"... Related Articles Repair of a severe palm injury with anterolateral thigh and ilioinguinal flaps: A case report. World J Clin Cases. 2021 Jan 16;9(2):502-508 Authors: Gong HY, Sun XG, Lu LJ, Liu PC, Yu X Abstract BACKGROUND: In daily life and work, there are more and more patients with trauma to the hand, which often results in skin and soft tissue defects. Although there are many repair methods, the function and appearance of the fingers will be adversely affected if the repair is inadequate. CASE SUMMARY: In the present report we describe an 18-year-old male patient whose right hand was mangled by a machine. X-ray imaging showed that a right hand bone (middle finger) was absent and the alignment was poor. After hospitalization, he was diagnosed with a severe right hand injury, skin and soft tissue defects, partial finger defects, and a skin degloving injury. He underwent reconstructive surgery with anterolateral thigh and ilioinguinal flaps. After two repair operations, satisfactory results were obtained, including good fracture healing, good skin flap shape, and good wrist joint function. CONCLUSION: This case highlights the good effect of anterolateral thigh and ilioinguinal flaps repair technique on severe palm injury. PMID: 33521122 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Indirect inguinal hernia containing portosystemic shunt vessel: A case report.

paythelady.612 shared this article with you from Inoreader Indirect inguinal hernia containing portosystemic shunt vessel: A case report. Μέσω pubmed: "world j clin cases"... Related Articles Indirect inguinal hernia containing portosystemic shunt vessel: A case report. World J Clin Cases. 2021 Jan 16;9(2):509-515 Authors: Yura M, Yo K, Hara A, Hayashi K, Tajima Y, Kaneko Y, Fujisaki H, Hirata A, Takano K, Hongo K, Yoneyama K, Nakagawa M Abstract BACKGROUND: Inguinal hernia repair is one of the most common general surgical operations worldwide. We present a case of indirect inguinal hernia containing an expanded portosystemic shunt vessel. CASE SUMMARY: We report a 72-year-old man who had a 4 cm × 4 cm swelling in the right inguinal region, which disappeared with light manual pressure. Abdominal-pelvic computed tomography (CT) revealed a right inguinal hernia containing an expanded portosystemic shunt vessel, which had been noted for 7 years due to liver cirrhosis. We performed Lichtenstein's herniorrhaphy and identified the hernia sac as being indirect and the shunt vessel existing in the extraperitoneal cavity through the internal inguinal ring. Then, we found two short branches between the expanded shunt vessel and testicular vein in the middle part of the inguinal canal and cut these branches to allow the shunt vessel to return to the extraperitoneal cavity of the abdomen. The hernia sac was returned as well. We encountered no intraoperative complications. After discharge, groin seroma requiring puncture at the outpatient clinic was observed. CONCLUSION: If an inguinal hernia patient has portal hypertension, ultrasound should be used to determine the contents of the hernia. When atypical vessels are visualized, they may be shunt vessels and additional CT is recommended to ensure the selection of an adequate approach for safe hernia repair. PMID: 33521123 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Recurrent inverted papilloma coexisted with skull base lymphoma: A case report.

paythelady.612 shared this article with you from Inoreader Recurrent inverted papilloma coexisted with skull base lymphoma: A case report. Μέσω pubmed: "world j clin cases"... Related Articles Recurrent inverted papilloma coexisted with skull base lymphoma: A case report. World J Clin Cases. 2021 Jan 16;9(2):516-520 Authors: Hsu HJ, Huang CC, Chuang MT, Tien CH, Lee JS, Lee PH Abstract BACKGROUND: Inverted papilloma is an uncommon neoplasm in the nasal cavity. It is a histologically benign tumor, but has a high recurrence and local invasion rate. In addition, nasal or skull base lymphoma is another rare neoplasm. The coexistence of these two tumors in one case makes the diagnosis and related treatment difficult. CASE SUMMARY: We report a case of an immunocompetent patient, who had a history of inverted papilloma 20 years ago. The patient presented with an infiltrated mass lesion in the nasal cavity with extension to the frontal base. The repeated biopsies revealed inverted papilloma without any malignant transformation. After the patient underwent a frontobasal craniotomy with total tumor excision, the final pathological examination revealed nasal inverted papilloma coexisting with diffuse large B-cell lymphoma of the skull base. CONCLUSION: Based on this case report, while managing a case of an aggressive recurrent inverted papilloma, not only squamous cell carcinoma transformation, but also other invasive malignancy, such as lymphoma, should be considered. PMID: 33521124 [PubMed] View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Circulatory Histidine levels for the assessment of disease activity in Takayasu arteritis A targeted NMR basedserum metabolomics study

xlomafota.13 shared this article with you from Inoreader Circulatory Histidine levels for the assessment of disease activity in Takayasu arteritis A targeted NMR basedserum metabolomics study Via OMICS International Umesh Kumar View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Eosinophilic Esophagitis and IgG4: Is There a Relationship?

xlomafota.13 shared this article with you from Inoreader Eosinophilic Esophagitis and IgG4: Is There a Relationship? Via Latest Results for Digestive Diseases and Sciences Abstract Our knowledge of the pathophysiology of eosinophilic esophagitis is constantly evolving. There is significant association between eosinophilic esophagitis and atopy; however, multiple studies have refuted the role of IgE in its pathogenesis. Instead, new data have demonstrated an elevated IgG4 level in patients with eosinophilic esophagitis. We review the current understanding of eosinophilic esophagitis pathogenesis and highlight the increasing evidence for the role of IgG4. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty [Pharmacology]

xloma.fota13 shared this article with you from Inoreader Population Pharmacokinetic and Pharmacodynamic Target Attainment Analysis of Cefazolin in the Serum and Hip Joint Capsule of Patients Undergoing Total Hip Arthroplasty [Pharmacology] Via AAC Accepts: Articles Published Ahead of Print The objectives of this study were to evaluate the population pharmacokinetics of prophylactic cefazolin (CFZ) from its serum and hip joint capsule concentrations in patients undergoing total hip arthroplasty, and to establish pharmacodynamic target concentration exceeding the MIC for designing an effective dosing regimen for serum and the hip joint capsule. We analyzed 249 serum samples and 125 hip joint capsule samples from 125 individuals using a nonlinear mixed-effects model. The pharmacodynamic index target value obtained from our results indicates the probability of maintaining CFZ trough and hip joint capsule concentrations exceeding the MIC of 1 mg/L, to account for methicillin-susceptible S. aureus (MSSA). We estimated the population pharmacokinetics using a two-compartment model. The estimated population pharmacokinetic parameters were as follows: CL (L/h) = 1.46 x (CLcr (mL/min)/77)0.891, Vc (L) = 7.5, Q (L/h ) = 3.38, and VJC (L) = 36.1. The probability of achieving concentrations exceeding the MIC90 for MSSA was approximately 100% for serum and 100% for the hip joint capsule at 3 h after the initial dose. Our findings suggest that population-based parameters are useful for evaluating CFZ pharmacokinetics and that individual dosages should be determined based on the dosage regimen that achieves and maintains adequate tissue CFZ concentration. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Epidemic territorial spread of IncP-2-type VIM-2 carbapenemase-encoding megaplasmids in nosocomial Pseudomonas aeruginosa populations [Epidemiology and Surveillance]

xloma.fota13 shared this article with you from Inoreader Epidemic territorial spread of IncP-2-type VIM-2 carbapenemase-encoding megaplasmids in nosocomial Pseudomonas aeruginosa populations [Epidemiology and Surveillance] Via AAC Accepts: Articles Published Ahead of Print In 2003-04 first five VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa (MPPA) isolates with an In4-like integron In461 (aadB–blaVIM-2–aadA6) on conjugative plasmids were identified in three hospitals in Poland. In 2005-15 MPPA much expanded in the country, and as many as 80 isolates in a collection of 454 MPPA (~18%) had In461, being one of two most common MBL-encoding integrons. The organisms occurred in 49 hospitals in 33 cities of 11/16 main administrative regions. PFGE and MLST classified them into 55 pulsotypes and 35 STs, respectively, revealing their remarkable genetic diversity overall, with only a few small clonal clusters. The S1 nuclease/hybridization assays and mating of 63 representative isolates showed that ~85% of these had large In461-carrying plasmids of ~350-550 kb, usually self-transmitting with high efficiency (~10–1-10–2 per donor cell). The plasmids fr om 19 isolates were sequenced, and subjected to structural and SNP-based phylogenetic analysis. These formed a subgroup within a family of IncP-2-type megaplasmids, observed worldwide in pseudomonads from various environments and conferring resistance/tolerance to multiple stress factors, including antibiotics. Their microdiversity in Poland arose mainly from acquisition of different accessory fragments, as well as new resistance genes and multiplication of these. Short-read sequence and/or PCR mapping confirmed the In461-carrying plasmids in the remaining isolates to be the IncP-2 types. The study demonstrated a large-scale epidemic spread of multi-drug resistance plasmids in P. aeruginosa populations, creating an epidemiological threat. It contributes to the knowledge on IncP-2 types, which are interesting research objects in resistance epidemiology, environmental microbiology and biotechnology. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.