Evaluation of the Neuroanatomical Basis of Olfactory Dysfunction

xlomafota13 shared this article with you from Inoreader Evaluation of the Neuroanatomical Basis of Olfactory Dysfunction Via JAMA Otolaryngology–Head & Neck Surgery Online First This cross-sectional study evaluates the role of the components of the olfactory pathway structures in impaired olfactory function. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Maternal Thyroid Hormone Programs Cardiovascular Functions in the Offspring

xlomafota13 shared this article with you from Inoreader Maternal Thyroid Hormone Programs Cardiovascular Functions in the Offspring Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Predictive Value of Serum Thyroglobulin for Structural Recurrence Following Lobectomy for Papillary Thyroid Carcinoma

xlomafota13 shared this article with you from Inoreader Predictive Value of Serum Thyroglobulin for Structural Recurrence Following Lobectomy for Papillary Thyroid Carcinoma Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thyroglossal Duct Cyst Located in the Thyroid Gland Misdiagnosed With Thyroid Carcinoma: A Case Report and Literature Review

xlomafota13 shared this article with you from Inoreader Thyroglossal Duct Cyst Located in the Thyroid Gland Misdiagnosed With Thyroid Carcinoma: A Case Report and Literature Review Via ear nose throat Ear Nose Throat J. 2021 Aug 26:1455613211040583. doi: 10.1177/01455613211040583. Online ahead of print. ABSTRACT The clinicopathologic features of thyroglossal duct cyst when it develops ectopically in the thyroid gland remain unclear because of its rarity, which makes diagnosis difficult. Clinical diagnosis and treatment should not disregard the possibility of thyroglossal cysts located in the thyroid gland. We here report the current case to prepare others and provide data for the diagnosis and treatment of this kind of disease. PMID:34433310 | DOI:10.1177/014556132110 40583 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

High-grade salivary gland cancer: is surgery followed by radiotherapy an adequate treatment to reach tumor control? Results from a tertiary referral centre focussing on incidence and management of distant metastases

xlomafota13 shared this article with you from Inoreader High-grade salivary gland cancer: is surgery followed by radiotherapy an adequate treatment to reach tumor control? Results from a tertiary referral centre focussing on incidence and management of distant metastases Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Aug 26. doi: 10.1007/s00405-021-07024-9. Online ahead of print. ABSTRACT PURPOSE: Salivary Gland cancer (SGC) is a rare and heterogenous group of tumors. Standard therapeutic options achieve high local but poor distant control rates, especially in high-grade SGC. The aim of this monocentric study was to evaluate patterns of recurrence and its treatment options (local ablative vs. systemic) in a homogenously treated patient population with high-grade SGC after surgery and radio(chemo)therapy. METHODS: Monocentric, retrospective study of patients with newly diagnosed high-grade salivary gland cancer. We retrospectively reviewed clinical reports from 69 patients with high-grade salivary gland cancer in a single-center audit. Survival rates were calculated using the Kaplan-Meier method and prognostic variables were analyzed (univariate analysis: log-rank test; multivariate analysis: Cox regression anal ysis). RESULTS: The median time of follow-up was 31 months. After 5 years, the cumulative overall survival was 65.2%, cumulative incidence of local recurrence was 7.2%, whereas the cumulative incidence of distant metastases was 43.5% after 5 years. 30 of 69 patients developed distant metastases during the time of follow-up, especially patients with adenoid cystic carcinoma, salivary duct carcinoma, adenocarcinoma NOS and acinic cell carcinoma with high-grade transformation. The most common type of therapy therefore was chemotherapy (50%). 85.7% of patients with local ablative therapy of distant metastases show disease progression during follow-up afterwards. CONCLUSION: With surgery and radio-chemotherapy, a high rate of loco-regional control is reached, but over 40% of patients develop distant metastases in the further follow-up which usually present a diffuse pattern involving in a diffuse metastases. Therefore, in the future, intensified interdisciplinary combination therapies even in the first-line treatment in certain subtypes of high-grade SGC should be investigated. PMID:34436631 | DOI:10.1007/s00405-021-07024-9 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Inhibitory gating of coincidence-dependent sensory binding in secondary auditory cortex

xlomafota13 shared this article with you from Inoreader Inhibitory gating of coincidence-dependent sensory binding in secondary auditory cortex Via cortical auditory Nat Commun. 2021 Jul 29;12(1):4610. doi: 10.1038/s41467-021-24758-6. ABSTRACT Integration of multi-frequency sounds into a unified perceptual object is critical for recognizing syllables in speech. This "feature binding" relies on the precise synchrony of each component's onset timing, but little is known regarding its neural correlates. We find that multi-frequency sounds prevalent in vocalizations, specifically harmonics, preferentially activate the mouse secondary auditory cortex (A2), whose response deteriorates with shifts in component onset timings. The temporal window for harmonics integration in A2 was broadened by inactivation of somatostatin-expressing interneurons (SOM cells), but not parvalbumin-expressing interneurons (PV cells). Importantly, A2 has functionally connected subnetworks of neurons preferentially encoding harmonic over inharmonic sounds. These subnetworks are stable across days and exist prior to experimental harmoni cs exposure, suggesting their formation during development. Furthermore, A2 inactivation impairs performance in a discrimination task for coincident harmonics. Together, we propose A2 as a locus for multi-frequency integration, which may form the circuit basis for vocal processing. PMID:34326331 | PMC:PMC8322099 | DOI:10.1038/s41467-021-24758-6 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Potential long-term developmental toxicity of in utero and lactational exposure to Triclocarban (TCC) in hampering ovarian folliculogenesis in rat offspring

xlomafota13 shared this article with you from Inoreader Potential long-term developmental toxicity of in utero and lactational exposure to Triclocarban (TCC) in hampering ovarian folliculogenesis in rat offspring Via histochem Acta Histochem. 2021 Aug 21;123(6):151772. doi: 10.1016/j.acthis.2021.151772. Online ahead of print. ABSTRACT Triclocarban (TCC), an antimicrobial compound commonly added to a wide range of household and personal hygiene care products, is one of the most prevalent endocrine-disrupting substances (EDS). This study was conducted to elucidate whether in utero and lactational exposure to TCC could adversely affect folliculogenesis and the onset of puberty in female rat offspring . Twenty pregnant Sprague Dawley rats were equally divided into Control and TCC dam groups (supplemented daily with drinking water enriched with 0.5 mg/L of TCC) from gestational day5 to postnatal day21 (PND21). Female offspring, 20 from control and 20 from TCC dams, were subdivided into 4 subgroups (PND21, PND28, PND35 & PND42). The day of vaginal opening and first estrous cycle were determined. Ovarian sections of the offspring were processed for H&E staining and for immunohistochemical expression of Ki67, Caspase-3 and androgen receptors (AR) on the granulosa cells of ovarian follicles. Follicular count and atretic index were assessed besides, serum estradiol, progesterone, FSH and LH, C-reactive protein (CRP), malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. TCC offspring exhibited a significant delay in the onset of puberty and impedance of normal transition of the primordial follicles to more developed ones with altered cyctoarchitecture. Also, TCC decreased follicular count, proliferation and gonado-somatic index while it increased atretic index, apoptosis and AR of the granulosa cells along with disturbance of the feminine hormonal profile and oxidant/antioxidant balance. This study highlighted the potential long-term consequences of in utero and lactational exposure to TCC on the postnatal development of the ovary in rat offspring. PMID:34428603 | DOI:10.1016/j.acthis.2021.151772 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.