Phonosurgery Training in Human Larynx Preserved with Thiel’s Embalming Method

xlomafota13 shared this article with you from Inoreader Phonosurgery Training in Human Larynx Preserved with Thiel's Embalming Method Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Background: To describe the suitability of larynges preserved with Thiel's embalming method for phonosurgery training. Methods: A training model for phonosurgery techniques simulating vocal pathology and glottal insufficiency is developed to compare and evaluate the perception of embalmed vocal cords through a voluntary and anonymous survey rated on a scale of 1–5. A total of 10 residents and young otolaryngologists participated in the surgical training in phon osurgery. Results: Ten larynges preserved in formalin and 10 Thiel's embalmed larynges were used for the investigation. Phonosurgery procedures were performed following microflap and injection laryngoplasty techniques. The larynges preserved with Thiel's method demonstrated vocal cords that maintain their pliability and good tissue quality allowing a sensation of realism compared to the living body and providing suitable conditions for realistic laryngeal training. Participants held a positive experience, believed them to be useful and that these models of embalmed larynges were similar to the clinical setting and improved skills and confidence in performing phonosurgery. Conclusions: The human larynges embalmed with Thiel's method maintain the pliability of the vocal cords, thus representing a unique model to practice and reproduce training for endolaryngeal procedures without the risks of contamination, anatomical variation, or rigidity of other m odels. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cancerous and non-neoplastic stem cells in the stomach similarly express CD44 and CD133

xlomafota13 shared this article with you from Inoreader Cancerous and non-neoplastic stem cells in the stomach similarly express CD44 and CD133 Via histochem Acta Histochem. 2021 Sep 10;123(7):151787. doi: 10.1016/j.acthis.2021.151787. Online ahead of print. ABSTRACT CD44 and CD133 have been considered as cancer stem cell (CSC) markers. Stem cell markers are rarely described in healthy stomach tissues. However, the clinicopathological and prognostic value of CD44 and CD133 in gastric cancer remains controversial. This study investigated the expression of CD44 and CD133 in gastric cancer and non-neoplastic gastric mucosa. We used samples of primary gastric adenocarcinomas (n = 69), metastatic lymph nodes (n = 30), intestinal metaplasia (n = 17), and histologically normal gastric tissues of surgical margins (n = 54). The expression of CD44 and CD133 were studied in samples by immunohistochemistry. Fisher's exact test and a logistic regression model were used in this study. CD44 expression was observed in 12% of samples with intestinal metaplasia, 20% with lymph node metastases, 22% with normal mucosa, to 30% of samples with primary tumors. Most of these positive tumors showed immunostaining in less than 4% of cancerous cells, mainly in the diffuse type. CD133 expression was observed in 7% (intestinal metaplasia) to 46% (normal mucosa). In the positive cases of cancer (24%), in most of them, less than 3% of cells were marked. CD44 and CD133 expression in the histologically normal gastric mucosa was restricted to the deeper regions of the gastric crypts at the level where stem cells and progenitor cells are usu ally found. CD44 and CD133 expression occurs in few gastric cancer cells, mainly in diffuse carcinomas, and are expressed in histologically normal gastric mucosae. None of the markers are specific for cancer and are also present in intestinal metaplasia and the normal mucosa. PMID:34517259 | DOI:10.1016/j.acthis.2021.151787 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The influence of age on the anatomical variability of sciatic nerve divisions in the thigh: an ultrasound study

xlomafota13 shared this article with you from Inoreader The influence of age on the anatomical variability of sciatic nerve divisions in the thigh: an ultrasound study Via radiol anat Surg Radiol Anat. 2021 Sep 13. doi: 10.1007/s00276-021-02824-4. Online ahead of print. ABSTRACT PURPOSE: The Sciatic Nerve Division (SND) into the Common Peroneal Nerve and Tibial Nerve presents a great anatomical variability in its location in the thigh, but the influence of age on it has not been fully addressed. METHODS: Anatomical distances from greater trochanter to SND and from SND to popliteal crease were obtained by ultrasound examination in 60 children (age 1- 12 years) and 60 adult patients (age 13-80 years) who were scheduled for programmed surgery. A sciatic nerve/thigh coefficient [Greater Trochanter-SND/(Greater Trochanter-popliteal crease)*100] and its coefficient of variation (standard deviation/mean*100) were calculated. Greater Trochanter-SND and SND-Popliteal crease were also correlated with patients´ age, weight and height. RESULTS: There were statistically significant differences between children and adult in Greater Trochanter-SND (20.5 ± 5,5 vs 33.9 ± 2.7; p < 0.0001) and in SND-Popliteal (4.9 ± 2.1 vs 6.7 ± 1.6; p < 0.0001) distances measured in cm. There were also statistically significant differences between children and adults in Sciatic nerve/thigh coefficient (80% vs 83%; p < 0.0001) and its index of variation (8.1% vs 4.8%; p < 0.0001). In children, both Greater Trochanter-SND and SND-Popliteal distances were strongly correlated with age (r2 = 0.868 and r2 = 0.261, respectively; p < 0.0001), weight (r2 = 0.778 and r2 = 0.278, respectively; p < 0.0001) and height (r2 = 0.898 and r2 = 0.225, respectively; p < 0.0001). However, in older patients, only Greater Trochanter-SND distance was statistically correlated with height (r2 = 0.372; p = 0.0001) and not with age or weight; SND-Popliteal distance did not show statistically relevant correlation, either. CONCLUSION: Children presented even more anatomical variability than adults in sciatic nerve division due to the growth of both the proximal and distal nervous structures of the thigh before 12 years of age. PMID:34515831 | DOI:10.1007/s00276-021 -02824-4 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Post-dural puncture pseudomeningocele ('arachnoid bleb'): An underrecognized etiology of spontaneous intracranial hypotension symptomatology

xlomafota13 shared this article with you from Inoreader Post-dural puncture pseudomeningocele ("arachnoid bleb"): An underrecognized etiology of spontaneous intracranial hypotension symptomatology Via leak of cerebrospinal fluid Clin Imaging. 2021 Sep 7;80:377-381. doi: 10.1016/j.clinimag.2021.08.023. Online ahead of print. ABSTRACT Spontaneous intracranial hypotension (SIH) is an important secondary cause of a persistent headache syndrome, classically presenting as sudden onset debilitating positional headaches related to reduced intracranial cerebrospinal fluid (CSF) volume. Current understanding of SIH pathogenesis recognizes three underlying etiologies: dural tear, meningeal diverticulum, and CSF-venous fistula, with a fourth broad category of indeterminate/unknown etiologies. Post-dural puncture headache (PDPH) is a well-known and common complication of dural puncture, typically remitting spontaneously within two weeks of onset or with autologous epidural blood patch, though with some patients developing complex and difficult to manage chronic PDPH. Herein, we present a case of chronic PDPH resulting in SIH symptomatology secondary to a post-dural puncture pseud omeningocele, or "arachnoid bleb," successfully treated with curative surgical intervention. Increasing awareness of additional potential etiologies of SIH symptomatology will allow for improved detection for targeted definitive therapy, ultimately improving patient outcomes including quality of life in this debilitating and difficult to manage secondary headache syndrome. PMID:34517304 | DOI:10.1016/j.clinimag.2021.08.023 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Tracheoesophageal fistula and pharyngoesophageal stenosis repair by double skin paddle radial forearm flap

xlomafota13 shared this article with you from Inoreader Tracheoesophageal fistula and pharyngoesophageal stenosis repair by double skin paddle radial forearm flap Via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 14 September 2021 Source: European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): V. Poissonnet, D. Culie, C. Rouanet, A. Bozec View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children

xlomafota13 shared this article with you from Inoreader Comparing the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Sep 14. doi: 10.1007/s00405-021-07049-0. Online ahead of print. ABSTRACT INTRODUCTION: In this study we aimed to compare the efficacy of peritonsillar injection of bupivacaine and intravenous acetaminophen on post-tonsillectomy pain in children. MATERIALS AND METHODS: In this randomized double-blind clinical trial study 60 children with ASA = I-II aged 5-12 years undergoing tonsillectomy were involved. The first group received bupivacaine at a dose of 0.1 mg/kg that was injected into the bed and the anterior crease of each tonsil. The second group was given intravenous acetaminophen at a dose of 12.5 mg/kg. The patient's pain score at 10, 30, 60 min after his/her admission to recovery room and 120, 240 and 360 min after the surgery was recorded using CHEOPS. Patient's sedation score, nausea or vomiting, the time of the first request for analgesia and the time of starting oral feeding were recorded and analyzed too. RESULTS: There was no significant differences in mean age (p value = 0.44), gender (p value = 0.79), weight (p value = 0.36), height (p value = 0.17), anesthesia duration (p.value = 0.85) and surgery duration (p.value = 0.73) between two groups. Postoperative pain was significantly less in the bupivacaine group at 240 and 360 min after the surgery. The mean sedation score was higher in the bupivacaine group but not significantly. There was no significant difference between groups regarding the nausea and vomiting, the first analgesics request time and the start time of oral feeding. CONCLUSION: According to the results of the present study, since administration of peritonsillar bupivacaine compared to acetaminophen had a better effect on managing postoperative pain and improving sedation and also since no complications were reported; therefore, peritonsillar infiltration with bupivacaine is suggested for pediatric tonsillectomy. PMID:34518906 | DOI:10.1007/s00405-021-07049-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Positionspapier: Hinweise zur Patienteninformation und -aufklärung vor Anwendung von Biologika bei chronischer Rhinosinusitis mit Nasenpolypen (CRSwNP) – Teil 2: Omalizumab – Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC)

xlomafota13 shared this article with you from Inoreader Positionspapier: Hinweise zur Patienteninformation und -aufklärung vor Anwendung von Biologika bei chronischer Rhinosinusitis mit Nasenpolypen (CRSwNP) – Teil 2: Omalizumab – Empfehlungen des Ärzteverbandes Deutscher Allergologen (AeDA) und der Deutschen Gesellschaft für HNO-Heilkunde, Kopf- und Halschirurgie (DGHNOKHC) Via Laryngo-Rhino-Otologie Laryngorhinootologie DOI: 10.1055/a-1592-0316 Hintergrund Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) ist eine multifaktorielle entzündliche Erkrankung, oftmals auf der Grundlage einer Typ-2-Inflammation. Für die Behandlung von Patienten mit einer schweren Ausprägung ohne ausreichendes Ansprechen auf die Standardtherapie mit topischen nasalen Steroiden und/oder Zustand nach endonasaler Operation sind als Biologika aktuell Dupilumab und Omalizumab für die Therapie zugelassen. Nachdem wir in einer früheren Publikation für Dupilumab bereits entsprechende Hinweise gegeben haben, ist das Ziel der vorliegenden Arbeit die Standardisierung von Patienteninformation und -aufklärung vor einer Therapie mit Omalizumab. Methoden Auf Grundlage des aktuellen Wissensstandes zur Immunologie der CRSwNP und zu den erwünschten und möglichen unerwünschten Wirkungen von Omalizumab werden Empfehlungen für die Patienteninformation entwickelt. Ergebnisse Basierend auf der internationalen Literatur, der aktuellen Fachinformation und Erfahrungen aus der praktischen Anwendung und den derzeitigen Pharmakovigilanz-Daten hat ein Expertengremium Empfehlungen für die Patienteninformation und -aufklärung zur Anwendung von Omalizumab bei CRSwNP entwickelt und auf dieser Grundlage einen Patienteninformations- und Aufklärungsbogen erstellt. Schlussfolgerung Die Information und Einwilligung des Patienten wird vor der Verordnung bzw. Verabreichung von allen Biologika, damit auch Omalizumab, empfohlen. Das vorliegende Positionspapier enthält wichtige Informationen zur praktischen Umsetzung und einen Vorschlag für eine Patienteninformation. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.