Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Κυριακή 15 Μαΐου 2022

Systematic Review of CT Angiography in Guiding Management in Pediatric Oropharyngeal Trauma

alexandrossfakianakis shared this article with you from Inoreader
Systematic Review of CT Angiography in Guiding Management in Pediatric Oropharyngeal Trauma

The utility of CT angiography (CTA) in children with minor appearing oropharyngeal trauma is controversial. This article is a systematic review of the changes in diagnosis and treatment based on CTA results in pediatric patients with oropharyngeal trauma.


Objectives

Pediatric oropharyngeal trauma is common. Although most cases resolve uneventfully, there have been reports of internal carotid artery injury leading to devastating neurovascular sequelae. There is significant controversy regarding the utility of CT angiography (CTA) in children with seemingly minor oropharyngeal trauma. The goal of this study was to appraise changes in diagnosis and treatment based on CTA results.

Methods

A comprehensive search of PubMed, Embase, CINAHL, Scopus, the Cochrane Ear, Nose and Throat Disorders Group Trials Register, and the ClinicalTrials.gov database was performed following PRISMA guidelines.

Results

The search yielded 5,078 unique abstracts, of which 8 articles were included. A total of 662 patients were included, with 293 having any CT head/neck imaging, and 255 with CTA. Eleven injuries/abnormalities of the carotid were found on CTAs, comprising edema around the carotid (n = 8), potential intimal tear (n = 1), carotid spasm (n = 1), and carotid compression (n = 1). The pooled proportion of imaging findings on CTA that could lead to changes in clinical management was 0.00 (95% CI 0.00–0.43). Angiography was obtained in 10 patients, in 6 cases due to abnormal CTA. Angiography identified 1 patient with vessel spasm and two patients with carotid intima disruption without thrombus. No patient underwent vascular repair or suffered cerebrovascular injury.

Conclusion

Imaging with CTA yielded radiological abnormalities in a few instances. These results do not support the routine use of CTA in screening pediatric oropharyngeal trauma when balanced against the risk of radiation, as it rarely resulted in management changes and was not shown to improve outcomes.

Level of Evidence

N/A Laryngoscope, 2022

View on Web

Pharmacological and clinical monitoring in children with acute lymphoblastic leukemia treated with a biogeneric PEG‐l‐asparaginase product

alexandrossfakianakis shared this article with you from Inoreader

Abstract

Background

l-Asparaginase (ASP) plays a crucial role in the treatment of childhood acute lymphoblastic leukemia (ALL). Currently, different ASP products are available in the market, including both native and pegylated drugs. Several biogeneric Escherichia coli ASP (GEN-ASP) products have been developed in response to shortages and expensiveness of the native E. coli ASP innovator compounds, but some concerns have been raised about their quality. Recently, a number of generic pegylated ASP products (GEN-PEG-ASP) have been marketed to substitute for the innovator product (PEG-ASP).

Methods

Clinical courses and serum asparaginase activity (SAA) levels were monitored in 12 children with ALL, who were treated in our institution with two doses of a GEN-PEG-ASP product, given IV at 2500 IU/m2 during the remission induction phase. Results were compared with those obtained in a reference cohort of 35 patients treated in our institution, who received the innovator PEG-ASP product at same dosage and within the same chemotherapy background.

Results

Compared to the reference cohort treated with PEG-ASP, SAA levels were significantly lower in the 12 patients receiving GEN-PEG-ASP (p < .0001); a higher proportion of ASP-associated hypersensitivity reactions (2/12 vs. 0/35; p = .061) and silent inactivation (3/12 vs. 0/35; p = .014) were observed in comparison with the reference cohort.

Conclusions

Our results highlighted different pharmacological profiles and different rates of hypersensitivity reactions and silent inactivation in the GEN-PEG-ASP cohort compared to those treated with the innovator product. Our findings suggest that a rigorous clinical attention and a thorough pharmacological monitoring are advisable in patients treated with GEN-PEG-ASP products.

View on Web

Macroscopic Extranodal Extension In Oral Squamous Cell Carcinoma‐A Subgroup With Poor Survival

alexandrossfakianakis shared this article with you from Inoreader

Background

Oral cancer portends a significant cause of morbidity and mortality worldwide. Cervical lymph node metastasis with extranodal extension (ENE) is associated with a poor prognosis. There has been accumulating evidence regarding the extent of ENE to be associated with prognosis and survival.

Aim

This observational study was performed to analyze the prognostic implication of macroscopic and microscopic ENE in metastatic cervical lymph nodes of oral cavity cancer patients.

Methods

A total of 92 oral cavity cancer patients with pathologically detected ENE were included in this study. Both the groups (macroscopic and microscopic ENE) were compared in terms of overall survival and disease-free survival by using Kaplan –Meier. The pattern of failure was determined by Fischer's exact test. Univariate and multivariate analyses were calculated to determine the significant risk factors of death.

Results

The 2 years of disease-free survival and overall survival rates for the whole cohort were 51.2% and 53.9% respectively. The 2-year survival rate for the microscopic group (≤2 mm) and macroscopic (>2 mm) was 72.6% and 0% respectively, while the distant failure rate in the microscopic ENE group and macroscopic ENE group was 44.83% and 22.22% respectively (p-value = 0.026).

Conclusions

Macroscopic ENE (>2 mm) in oral cavity squamous cell cancer represents an aggressive entity with early regional and distant failure as compared to microscopic ENE (≤2 mm). Thus, macroscopic ENE (>2 mm) warrants a distinct subgroup with special consideration for intensification of treatment.

Level of Evidence

3 Laryngoscope, 2022

View on Web

Temporal lobe myxoid glioneuronal tumor, PDGFRA p.K385L‐mutant with DNA methylation confirmation

alexandrossfakianakis shared this article with you from Inoreader
View on Web

Association of oral bacteria with oral hygiene habits and self‐reported gingival bleeding

alexandrossfakianakis shared this article with you from Inoreader

Abstract

Aims

To describe associations of gingival bacterial composition and diversity with self-reported gingival bleeding and oral hygiene habits in a Norwegian regional-based population.

Material and methods

We explored gingival fluid microbiome composition (16S amplicon sequencing) in 484 adult participants (47% females, median age, 28 years) in the RHINESSA study in Bergen, Norway. We explored bacterial diversity and abundance differences by Community Periodontal Index (CPI) score, self-reported frequency of gingival bleeding and oral hygiene habits.

Results

Gingival bacterial diversity increased with increasing frequency of self-reported gingival bleeding, with higher Shannon diversity index for 'always' β = 0.51 and 'often' β = 0.75 (p < 0.001) compared to 'never' gingival bleeding. Frequent gingival bleeding was associated with higher abundance of several bacteria, such as Porphyromonas endodontalis, Treponema denticola, and Fretibacterium spp, but lower abundance of bacteria within the gram-positive phyla, Firmicutes and Actinobacteria. Flossing and rinsing with mouth wash twice daily was associated with higher total abundance of bacteria in the Proteobacteria phylum, but with lower bacterial diversity compared to those who never flossed or never used mouth wash.

Conclusion

A high frequency of self-reported gingival bleeding was associated with higher bacterial diversity than that found in participants reporting no gingival bleeding, and with higher total abundance of known periodontal pathogens such as Porphyromonas spp, Treponema spp, and Bacteriodes spp.

View on Web

Psychological risk indicators for peri‐implantitis: a cross‐sectional study

alexandrossfakianakis shared this article with you from Inoreader

Abstract

Aim

The aim of this analytical cross-sectional study was to evaluate the association between peri-implantitis and psychological distress, and potentially related/mediating factors such as general health, bruxism and lifestyle factors.

Material and methods

Patients having received dental implants at a private practice in the Netherlands between January 2011 and January 2014 were recalled on a 5-year clinical and radiographic follow-up examination. Presence of peri-implantitis was examined and patients completed questionnaires measuring psychological distress (Symptom Checklist-90), bruxism, general health and lifestyle factors. Associations between the self-reported factors and peri-implantitis were analyzed with univariable and multivariable logistic regression models.

Results

A total of 230 patients (with 347 implants) were included in the analysis. Prevalence of (mild to severe) peri-implantitis was 30% (69 patients). Variables that showed a significant univariable association with peri-implantitis (p<0.10) were: SCL-90 subdomain depression, smoking, current medical treatment and lung problems. In the multivariable regression analysis, only the variable depression was significantly associated with peri-implantitis (p<0.05).

Conclusions

The presence of depressive symptoms is a risk indicator for peri-implantitis. Recognizing the potential negative impact of depressive symptoms may allow for better identification of high risk patients.

View on Web

Comparison Between the STANDARD™ F S. pneumoniae Ag FIA and BinaxNOW S. pneumoniae Antigen Card for Detection of Streptococcus pneumoniae Urinary Antigen

alexandrossfakianakis shared this article with you from Inoreader

1-s2.0-S0732889322X00047-cov150h.gif

Publication date: Available online 15 May 2022

Source: Diagnostic Microbiology and Infectious Disease

Author(s): Hui-Jin Yu, Tae Yeul Kim, Hyang Jin Shim, Sun Ae Yun, Ji-Youn Kim, On Kyun Kang, Hee Jae Huh, Nam Yong Lee

View on Web