Current Opinion in Otolaryngology & Head and Neck Surgery

Published Ahead-of-Print The following 8 items were added to PAP on 8/31/2016. Review of adult laryngotracheal stenosis: pathogenesis, management, and outcomes. Rosow, David E.; Barbarite, Eric REVIEW: PDF Only Physical and virtual modelling of the head and neck for surgical simulation and training. Dirven, Steven; Allen, Jacqueline REVIEW: PDF Only Pediatric unilateral sensorineural hearing loss: implications and management. Dornhoffer, James R.; Dornhoffer, John L. REVIEW: PDF Only Editorial. Allen, Jacqui EDITORIAL: PDF Only Laryngeal framework surgery: current strategies. Hess, Markus M.; Fleischer, Susanne REVIEW: PDF Only Cricopharyngeal function or dysfunction: what's the deal?. Allen, Jacqui REVIEW: PDF Only Autoimmune swallowing disorders. Amos, Janine; Baron, Anthony; Rubin, Adam D. REVIEW: PDF Only Tissue engineering in the larynx and airway. Hertegård, Stellan REVIEW: PDF Only Current Opinion in Otolaryngology & Head and Neck Surgery

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

City, Culture and Society

City, Culture and Society  Volume 7, Issue 3 ,  Pages 123-196, September 2016  Editorial Board     Pages IFC    Original Research Articles Fragmentation and solidarity in the artistic milieu of contemporary Paris: A perspective from Emile Durkheim   Original Research Article  Pages 123-128  Christian Morgner  Rituals and the participation of urban form: Informal and formal image making processes   Original Research Article  Pages 129-138  Sukanya Krishnamurthy  Lost in protest, found in segregation: Divided cities in the light of the 2015 "Οχι" referendum in Greece   Original Research Article  Pages 139-148  Kostas Rontos, Efstathios Grigoriadis, Adele Sateriano, Maria Syrmali, Ioannis Vavouras, Luca Salvati  Spatialisation of selves: Religion and liveable spaces among Hindus and Muslims in the walled city of Ahmedabad, India   Original Research Article  Pages 149-154  Aparajita De  Commodification of art versus creativity: The Antagonist Art Movement in the expanding arts scene of New York City   Original Research Article  Pages 155-160  Ruth Trumble, Micheline van Riemsdijk  A typology of network city in a socio-economically disadvantaged region   Original Research Article  Pages 161-168  Yoon-Young Jeong, Tae-Heon Moon, Jung Hoon Han  An environmental and social approach in the modern architecture of Brazil: The work of Lina Bo Bardi   Original Research Article  Pages 169-185  Steffen Lehmann  Progressing urban development and life quality simultaneously   Original Research Article  Pages 186-193  Issa Ebrahimzadeh, Abdol Aziz Shahraki, Ali Akbar Shahnaz, Ayoub Manouchehri Myandoab    Urban Creativity Forum Urban regeneration & Valletta 2018     Pages 194-195  Karsten Xuereb

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182

6948891480

alsfakia@gmail.com

Effects of PTEN gene silencing on invasion and EMT in oral squamous carcinoma Tca8113 cells

Aim

To investigate the impact of silencing of the PTEN gene using siRNA on the invasion, proliferation, cell cycle, and epithelial-mesenchymal transition of the Tca8113 cell line.

Methods

The established Tca8113 cell model with siRNA interference to silence the PTEN gene was used. The transfection efficiency was examined by RT-qPCR and Western blot analysis. CCK-8 assay was utilized to analyze the proliferation of Tca8113 cells and cell invasion was evaluated using a transwell assay. The cell cycle distribution was analyzed by flow cytometry. The protein expression levels of the epithelial-mesenchymal transition (EMT) markers E-cadherin and Vimentin and the EMT-related proteins β-catenin and TGF-β1 were analyzed by Western blot.

Results

The expression level of PTEN was significantly reduced in the PTEN-siRNA group. The invasiveness and proliferation rate of Tca8113 cells in the PTEN-siRNA group were significantly greater than those of the control and negative control groups. The expression levels of E-cadherin and β-catenin were reduced, whereas the expression levels of vimentin and TGFβ-1 were elevated in the PTEN-siRNA group compared with those of control and negative groups. These results were significantly different.

Conclusion

The silencing of PTEN by siRNA increased the proliferation and promoted cell invasion of Tca8113 cells. PTEN gene silencing may accelerate the EMT in Tca8113 cells.

http://ift.tt/2bL80DK

Effects of honey use on the management of radio/chemotherapy-induced mucositis: a meta-analysis of randomized controlled trials

This meta-analysis aimed to assess the prophylactic effects of honey use on the management of radio/chemotherapy-induced mucositis. PubMed, Cochrane Library, Science Direct, China National Knowledge Infrastructure (CNKI), VIP (Chinese scientific journal database), and China Biology Medicine (CBM) were searched for relevant articles without language restriction. Two reviewers searched and evaluated the related studies independently. Statistical analyses were performed using Stata 11.0, calculating the pooled risk ratio (RR) with the corresponding 95% confidence interval (CI).

http://ift.tt/2bUlI4o

Effect of flap design on periodontal healing after impacted third molar extraction: a systematic review and meta-analysis

The extraction of an impacted third molar violates the surrounding soft and bony tissues. The surgeon's access to the tooth, for which there are various surgical approaches, has an important impact on the periodontium of the adjacent second molar. The aim of this review was to analyze the relationships between the different flap techniques and postoperative periodontal outcomes for the mandibular second molars (LM2) adjacent to the impacted mandibular third molars (LM3). An electronic search of MEDLINE and other databases was conducted to identify randomized controlled trials fulfilling the eligibility criteria.

http://ift.tt/2c3F76z

Analysis of Genetic and Non Genetic Risk Factors for Cisplatin Ototoxicity in Pediatric Patients

The aim of this study was to analyse the genetic and non genetic risk factors for cisplatin ototoxicity.

http://ift.tt/2co0eNh

Geographic variation in Medicare treatment costs and outcomes for advanced head and neck cancer

Head and neck cancer (HNC) refers to a heterogeneous group of malignancies that in the US afflicts 61,000 patients annually. The treatment of these diseases is complex and requires the input of several medical specialties and support services. While early stage HNC can be treated by single modality therapy, more advanced cases of disease require a multi-modality approach, which dramatically increases costs. Complex treatments result in a greater chance of variation in practice among providers and costs may vary substantially.

http://ift.tt/2cdH65r