Vitiligo and tumoral melanosis: signs of metastasis in a patient with melanoma

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Presence of the Merkel cell polyomavirus in Merkel cell carcinoma combined with squamous cell carcinoma in a patient with chronic arsenism

Summary

We present a case of Merkel cell carcinoma (MCC) coincident with squamous cell carcinoma (SCC) on the breast of a woman with chronic arsenism. This case demonstrates the distinct association of chronic arsenism with two different primary cutaneous carcinomas. Merkel cell polyomavirus (MCPyV) was identified in the lesional skin of the MCC but not in that of the SCC, suggesting there are different interactions of MCPyV in the pathogenesis of SCC and MCC related to arsenic. Physicians need to be vigilant in the occurrence of both SCC and MCC in patients with chronic arsenism. To our knowledge, this is the first study to show the presence of MCPyV in the MCC but not the SCC portion of an arsenic-induced tumour.

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ATA members elected to Endocrine Society Council 2017

Congratulations to ATA Members Susan J. Mandel, MD, MPH and Anthony Hollenberg, MD  who were elected to serve as Officers and Council for the Endocrine Society . Read More….

The post ATA members elected to Endocrine Society Council 2017 appeared first on American Thyroid Association.

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Stability of suxamethonium in pharmaceutical solution for injection by validated stability-indicating chromatographic method

To assess the stability of pharmaceutical suxamethonium (succinylcholine) solution for injection by validated stability-indicating chromatographic method in vials stored at room temperature.

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Agenesia nasal y otras malformaciones faciales: reporte de un caso de anomalía congénita y revisión de literatura

Publication date: Available online 22 October 2016
Source:Acta Otorrinolaringológica Española
Author(s): María del Carmen Navas-Aparicio, Cinthya Mora-Mesén




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Hypoparathyroidism following thyroidectomy: Predictive factors

Publication date: Available online 21 October 2016
Source:Acta Otorrinolaringológica Española
Author(s): Cristiana Coimbra, Francisco Monteiro, Pedro Oliveira, Leandro Ribeiro, Mário Giesteira de Almeida, Artur Condé
ObjectiveTo evaluate the incidence and predictive factors for transient and permanent hypocalcemia and hypoparathyroidism following thyroidectomy.MethodWe studied all the 162 patients that underwent thyroid surgery in the ENT department of the Centro Hospitalar Vila Nova Gaia/Espinho from January 2005 to December 2014. We reviewed pre-operative, 6h and 12h after surgery ionized calcium and PTH levels. All patients were reviewed and evaluated according to the following criteria: gender, age, thyroid function, histologic diagnosis of the specimen, surgery extension and presence or absence of hypoparathyroidism.ResultsThere were 31 (19.1%) cases of transient hypoparathyroidism and 8 (5%) of permanent hypoparathyroidism. No significant difference was found for transient hypoparathyroidism when patients were analyzed by gender. However, all cases of permanent hypoparathyroidism were observed in female individuals.Comparing hemithyroidectomy with all other surgical procedures, we found that extension of surgery was a great predictor of transient (p=0.0001) and permanent (p=0.001) hypoparathyroidism.Diagnosis of malignancy was a strong predictor of transient hypoparathyroidism (p=0.002). It was also associated with permanent hypoparathyroidism, although differences did not reach statistical significance (p=0.096).ConclusionExtension of surgery (total thyroidectomy) and diagnosis of malignancy are predictors of transient and permanent hypoparathyroidism.



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Diente ectópico intranasal

Publication date: Available online 21 October 2016
Source:Acta Otorrinolaringológica Española
Author(s): Paula Cruz Toro, Ignacio Clemente, Iván Domènech




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