Accuracy of fine needle aspiration cytology of thyroid lesion with corresponding histopathology: A single institutional experience

Nasar Alwahaibi, Jawhara Alsalami, Usha Rani Bai, Ritu Lakhtakia

Thyroid Research and Practice 2016 13(3):140-143

Aim: The aim of this study was to evaluate and compare the accuracy of fine needle aspiration cytology (FNAC) in the diagnosis of thyroid lesions with the final histopathologic diagnosis in the surgical specimens. Materials and Methods: A retrospective study was performed over an 11-year-period at Sultan Qaboos University Hospital, Sultanate of Oman. The records of all patients who had undergone FNAC and subsequent surgery for thyroid cancer were included. Cytological diagnosis was classified into five categories: Unsatisfactory, benign, papillary carcinoma, undifferentiated thyroid carcinoma, and suspicious for malignancy. Histopathological diagnosis was classified into two categories: Papillary carcinoma and other thyroid carcinomas. Results: A total of 1460 cases of FNAC thyroid were retrieved. Female to male ratio was 6.3:1, and the mean age was 43.4 years. There were 20 papillary carcinomas, two undifferentiated thyroid carcinomas, and 118 suspicious for malignancy representing 9.6% of all cases. Of these 140 FNAC cases, subsequent histopathologic diagnosis found in only 95 cases. Papillary carcinoma was seen in 83.16% followed by follicular and medullary types with a rate of 12.6% and 2.1%, respectively. Conclusion: The findings of this study showed that FNAC is a sensitive method for the diagnosis of thyroid lesion if cytological yield is adequate and papillary carcinoma is the most common type of thyroid cancer in our institution.

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Pulmonary hypertension: The thyroid connection

Pooja Prakash Prabhu, GD Ravindran, Jyothi Idiculla

Thyroid Research and Practice 2016 13(3):144-145

A 52-year-old female presented with exertional dyspnea and swelling of feet for 3 weeks. On examination, she was found to have tachycardia and hypertension, with a small goiter visible on her neck. All routine investigations were normal. Echocardiogram (ECHO) revealed moderate tricuspid regurgitation and severe pulmonary hypertension (PHTN). Pulmonary function tests were normal. There was no evidence of pulmonary embolism on computed tomography pulmonary angiogram. Immunology workup was negative. She was diagnosed to have hyperthyroidism, and a technetium-99 scan of the thyroid was suggestive of Graves' disease. She was treated with radio-iodine. And is euthyroid and asymptomatic. A repeat ECHO confirmed resolution of PHTN. This case is being reported to highlight the need to detect and treat hyperthyroidism, which can cause resolution of PHTN.

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Autoimmune thyroid disorder and recurrent depression: Clinicians must be aware of the links

Karishma Rupani, Avinash De Sousa, Nilesh Shah

Thyroid Research and Practice 2016 13(3):146-147



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Thyroid abnormalities and suicidality in patients with first-episode schizophrenia

Samir Kumar Praharaj

Thyroid Research and Practice 2016 13(3):147-148



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Author reply

Avinash De Sousa

Thyroid Research and Practice 2016 13(3):149-149



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Antidiabetic and hypolipidemic activities of Algerian Pistachia lentiscus L. leaves extract in alloxan-induced diabetic rats

Publication date: January 2017
Source:South African Journal of Botany, Volume 108
Author(s): A. Cherbal, M. Kebieche, E.m. Yilmaz, Z. Aydoğmuş, L. Benzaouia, M. Benguessoum, M. Benkedidah, K. Madani
AimThe current study was designed to investigate the antidiabetic and hypolipidemic properties of the 80% methanolic leaves extract of Pistachia lentiscus L., a medicinal plant commonly used in Algerian folk medicine for the treatment of diabetes.MethodsWe evaluated the effects of P. lentiscus L. leaves extract on blood glucose, cholesterol, triglycerides and insulin levels in alloxan-induced diabetic rats. The effects of the extract on α-amylase, sucrase and glucose uptake by yeast cells in vitro were also evaluated. For qualitative determination of biologically active compounds, RP-HPLC analysis of the extract was carried out.ResultsP. lentiscus L. extract exhibited a significant decrease in blood glucose as well as cholesterol and triglyceride levels and caused a significant increase in plasma insulin. In addition, it significantly increased glucose uptake in yeast cells and inhibited α-amylase and sucrase activities.ConclusionBased on its strong antidiabetic activity, P. lentiscus L. extract appears to be a potential herb for the treatment of diabetes and can be further explored for isolating the active component(s).



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Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors

Publication date: January 2017
Source:Archives of Oral Biology, Volume 73
Author(s): Marcelo Anderson Barbosa Nascimento, Cassiano Francisco Weege Nonaka, Carlos Augusto Galvão Barboza, Roseana de Almeida Freitas, Leão Pereira Pinto, Lélia Batista de Souza
ObjectivesThe present study evaluated the immunohistochemical expression of BMP-2 and BMP-4 and of their receptors (BMPR-IA and BMPR-II) in solid ameloblastoma (SA), unicystic ameloblastoma (UA) and adenomatoid odontogenic tumor (AOT) in order to obtain a better understanding of their role in the development and biological behavior of these tumors.DesignThis study analyzed these proteins in 30 cases of SA, 10 cases of UA, and 30 cases of AOT. Immunoexpression was evaluated in the parenchyma and stroma by attributing the following scores: 0, no stained cells; 1, ≤10%; 2, >10% and ≤25%; 3, >25% and ≤50%; 4, >50% and ≤75%.; 5, >75% stained cells.ResultsIn SAs, positive correlations were observed between the stromal and parenchymal expression of BMP-2 (p<0.001) and between the stromal expression of BMP-2 and BMP-4 (p=0.020), as well as between the stromal expression of BMPR-II and BMP-4 (p=0.001) and the stromal and parenchymal expression of BMPR-II (p<0.001). In UAs, correlations were detected between the stromal and parenchymal expression of BMP-4 (p=0.035) and between the stromal expression of BMP-4 and BMPR-IA (p=0.022). In AOTs, analysis of immunoexpression in the parenchyma revealed positive correlations between all proteins.ConclusionBMPs and their receptors play an important role in the differentiation and development of ameloblastomas and AOTs, but may not explain the different biological behaviors of these lesions. The positive correlation observed in AOTs might be related to the formation of mineralized material in this tumor.



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