Rat model of chronic tympanic membrane perforation: A longitudinal histological evaluation of underlying mechanisms

Publication date: Available online 25 December 2016
Source:International Journal of Pediatric Otorhinolaryngology
Author(s): Allen Y. Wang, Lawrence J. Liew, Yi Shen, Jeffrey T. Wang, Magnus von Unge, Marcus D. Atlas, Rodney J. Dilley
ObjectiveTo evaluate histologically the progressive development and underlying mechanisms of chronic tympanic membrane perforation (TMP) in a rat model using a two-weeks ventilation tube (VT) treatment combined with topical application of mitomycin C/dexamethasone (VT-M/D), compared with normal tympanic membrane and acute TMPs.MethodsFifty male Sprague-Dawley rats were divided into three experimental groups: a normal control group (n = 5), an acute TMP group (n = 5) (i.e. 3 days post-myringotomy) and a VT-M/D group (n = 40). The TMs were regularly assessed by otoscopy. The normal control animals were sacrificed on day 0 and the acute TMP group was sacrificed 3 days post-myringotomy for histological and immunohistochemical evaluations. The VT-M/D group was sacrificed at various time points - 14 and 17 days, 3, 4, 6, 8 and 10 weeks.ResultsOn longitudinal histological examination, compared with normal TM and acute TMP, the perforation edges at the later time points illustrated thickened stratified squamous epithelium rimming around the edges, significant increase in keratin and collagen deposition, increased macrophage infiltration as well as reduced cellular proliferation. Three phases of TMP healing process were identified - the acute healing phase (3–17 days), the transition phase (3–4 weeks) and the chronic phase (6–10 weeks).ConclusionBased on the histological results of this study, the progressive development of chronic TMPs appeared to be associated with increased epidermal thickening, collagen and keratin deposition, macrophage infiltration and reduced cellular proliferation. After the 3–4 weeks of transition phase, the TMPs seemed to have transformed into a non-healing chronic TMP between 6 and 10 weeks.



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This second edition of “Fractures of the facial skeleton” is a soft cover book of 166 pages written for...

This second edition of "Fractures of the facial skeleton" is a soft cover book of 166 pages written for postgraduate students, trainees and practitioners dealing with facial trauma in the craniomaxillofacial region. It follows the first edition published in 2001. In 10 chapters dealing with well chosen facial trauma topics an excellent overview of the basics is provided including incidence, aetiology, general principles of treatment, emergency management of facial trauma, clinical features, imaging, treatment of hard and soft tissue injuries, post-operative care and complications.

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Corrigendum to “Oral microbiome, periodontitis and risk of head and neck cancer” [Oral Oncol. 53 (2016) 17–19]

The authors regret the error published on Page 17, Line 8. Please note the corrected statement: "Still, germ-free rats presented with lower acetaldehyde concentration, indicating that might exist a link between poor oral hygiene, alcohol consumption and increased risk of OCC [2,6]".

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Fractures of the Facial Skeleton, 2nd ed., M. Perry, A. Brown, P. Banks. Wiley Blackwell (2015), ISBN: 978-1-119-96766-8

Publication date: Available online 24 December 2016
Source:International Journal of Oral and Maxillofacial Surgery
Author(s): Eppo Wolvius




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Use of pentoxifylline and tocopherol in radiation-induced fibrosis and fibroatrophy

Radiation-induced fibrosis in the head and neck is a well-established pathophysiological process after radiotherapy. Recently pentoxifylline and tocopherol have been proposed as treatments to combat the late complications of radiation-induced fibrosis and a way of dealing with osteoradionecrosis. They both have a long history in the management of radiation-induced fibrosis at other anatomical sites. In this paper we review their use in sites other than the head and neck to illustrate the potential benefit that they offer to our patients.

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Star excursion balance test for assessment of dynamic instability of the ankle in patients after harvest of a fibular free flap: a two-centre study

We aimed to show that the star excursion balance test can identify instability in the ankle of patients who have had harvest of a fibular free flap. We compared the reach distance of the operated leg against that of the non-operated leg in 26 patients who had had harvest of the flap over a period of three years from August 2009 at two different centres. The goal of the test is to reach as far as possible with one leg in eight directions while balancing on the other. We also assessed the overall function of the operated leg using the Foot and Ankle Disability Index (FADI) and the American Orthopaedic Foot and Ankle Score (AOFAS).

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Postoperative radiotherapy for patients with oral squamous cell carcinoma with intermediate risk of recurrence: a case match study

Introduction/Aims: The purpose of this study was to determine the effect of postoperative radiotherapy (PORT) on recurrence and survival in patients with oral squamous cell carcinoma (OSCC) of intermediate risk of recurrence.

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