IL-17A polymorphism and elevated IL-17A serum levels are associated with oral lichen planus

Abstract

Objective

The aim of this study was to evaluate the association of IL-17A G197A polymorphism and serum levels with oral lichen planus susceptibility and clinical presentation.

Subjects and Methods

Eighty three individuals diagnosed with oral lichen planus (OLP) and ninety nine healthy controls (C) were consecutively recruited. All participants had desquamating oral mucosal cells collected and DNA isolated for IL-17A (G197A) genotyping. Blood samples of 42 OLP individuals and 23 healthy controls were collected for evaluation of IL-17A serum levels.

Results

IL-17A G197A genotypes were associated with an increased chance of having OLP (GA/AAxGG, OR=3.44, IC95%=1.87–6.33, p<0.001). Overall A carriers (GA or AA) were more common in OLP (38.1%) than in C (20.2%) (OR=2.43, IC95%= 1.53–3.87, p<0.001). Serum levels of IL-17A were higher among patients with oral lichen planus than in healthy controls (reticular, p=0.0003; erosive, p<0.001), but no difference was found among the disease types.

Conclusions

IL-17A G197A is associated with a higher susceptibility of developing oral lichen planus and these patients seem to present a considerable increase of IL-17A serum levels. These findings suggest that Th17 cells, and IL-17A in particular, may play a pivotal role in oral lichen planus pathogenesis.

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Annual Scientific Meeting of Neuroanaesthesia and Critical Care Society of Great Britain and Ireland, 2017: A Report.

No abstract available

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High Flow Nasal Cannula, A Novel Approach to Airway Management in Awake Craniotomies.

No abstract available

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The risk ratio for development of hereditary sensorineural hearing loss in consanguineous marriage offspring

Publication date: October 2017
Source:International Journal of Pediatric Otorhinolaryngology, Volume 101
Author(s): Hossam Sanyelbhaa, Abdelmagied Kabel, Heba Abd El-Rehem Abo El-Naga, Ahmed Sanyelbhaa, Hatem Salem
ObjectivesThis study aims to define the relative risk of development of hearing loss in offspring of consanguineous marriages.Materials and methodsThis is a retrospective case-control study conducted in a tertiary referral center in Jeddah, KSA. The study group included 1600 probands (848 males, 752 females), with age range 0.5–12 years (6.6 ± 3.6). The study group comprised of two equal, age and sex matched subgroups; Hearing Loss (HL) group and Normal Hearing (NH) group. The children included in the HL group should have idiopathic or non syndromic genetic sensorineural hearing loss.ResultsThe HL Group comprised 800 children with variable degrees of sensorineural hearing loss. Profound and severe degrees of hearing loss were the most prevalent degrees (P <0.05%). The prevalence of consanguineous marriage offspring in the NH group was 42.5%, while in the HL group it was 68.9% (P < 0.05). The differences between both study subgroups regarding the distribution of different degrees of parental consanguinity (first, second, double first, and first once removed cousins) were insignificant (P > 0.05). The relative risk and 95% confidence interval (RR, 95% CI) for development of hearing loss in offspring of consanguineous marriage was 1.76 (95% CI 1.57–1.97, P < 0.001).ConclusionsThere was 76% increased risk for consanguineous marriage progeny to develop SNHL when compared to non consanguineous progeny.



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