Heterogeneity in Positive Predictive Value of RAS Mutations in Cytologically Indeterminate Thyroid Nodules

Thyroid, Ahead of Print.


https://ift.tt/2k4QIDx

Identification of a Recurrent LMO7–BRAF Fusion in Papillary Thyroid Carcinoma

Thyroid, Ahead of Print.


https://ift.tt/2rNkOyF

Predominantly cystic clear cell renal cell carcinoma and multilocular cystic renal neoplasm of low malignant potential form a low-grade spectrum

Abstract

Multilocular cystic renal cell carcinoma has been recently excluded from clear cell renal cell carcinoma (CCRCC) category and re-designated as multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) due to its uniformly good outcomes. While strict distinction between MCRNLMP from predominantly cystic CCRCC (pc-CCRCC) is being emphasized, the significance of extensive true cystic component in CCRCC has not been investigated. Herein, we analyzed 57 MCRNLMP, 69 pc-CCRCC, and 46 non-cystic CCRCC. There were no statistically significant differences between the three subtypes in age, gender, and laterality. ISUP grades were 1 (73%) or 2 (27%) for MCRNLMP; for pc-CCRCC were 1 (31%), 2 (60%), and 3 (9%); and for non-cystic CCRCC were 1 (9%), 2 (52%), 3 (26%), and 4 (13%). MCRNLMP were either pT stage 1 (91%) or 2 (9%), pT stages for pc-CCRCC were 1 (92.5%), 2 (1.5%), and 3 (6%) and for non-cystic CCRCC were 1 (58.7%), 2 (6.5%), and 3 (34.8%). None of MCRNLMP patients developed recurrences or metastases, and only 1 contralateral kidney tumor and 1 metastasis developed in pc-CCRCC. In contrast, 19 patients with non-cystic CCRCC developed metastases (5-year PFS 58%, CI 38.3–73.5%), and 1 patient died of disease. Monosomy 3 was common in both MCRNLMP (3/3) and pc-CCRCC (6/7). This large series of MCRNLMP confirms its indolent behavior, shows that pc-CCRCC has significantly better prognosis than non-cystic CCRCC and may define the lower grade spectrum of CCRCC. We recommend that the presence and extent of CCRCC cystic component should be documented in the pathology report.

https://ift.tt/2rL6TZO

Allergen‐specific immunotherapy induces regulatory T cells in an atopic dermatitis mouse model

Allergy, EarlyView.


https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13465?af=R

Incidence of pediatric atopic dermatitis following thymectomy: A Danish register study

Allergy, EarlyView.


https://onlinelibrary.wiley.com/doi/abs/10.1111/all.13457?af=R

A Commentary on: “Effects of Regular Physical Activity on the Cognitive Performance of Type 2 Diabetic Patients: A systematic Review” by Podolski et al. (Metab Syndr Relat Disord 2017;15:481–493)

Metabolic Syndrome and Related Disorders, Ahead of Print.


https://ift.tt/2Irb30l

La charte éthique et déontologique des facultés de médecine et d’odontologie françaises

Publication date: June 2018
Source:Annales françaises d'Oto-rhino-laryngologie et de Pathologie Cervico-faciale, Volume 135, Issue 3
Author(s): O. Laccourreye, H. Maisonneuve




https://ift.tt/2IuTlsw