HMGB1 Binding to the RAGE Receptor Contributes to the Pathogenesis of Asthma

Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.


https://ift.tt/2BV0X9f

HMGB1 Binding to the RAGE Receptor Contributes to the Pathogenesis of Asthma

Pediatric Allergy, Immunology, and Pulmonology, Ahead of Print.


https://ift.tt/2PH0ZEr

Carnitine palmitoyltransferase type 2 deficiency: novel mutation in a Native South American family with whole-body muscle magnetic resonance imaging findings: two case reports

The myopathic form of carnitine palmitoyltransferase type II deficiency is an inherited autosomal recessive metabolic myopathy usually starting in childhood. Most reports have been on European and Japanese pop...

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Early‐onset neutropenia after rituximab therapy for bullous pemphigoid

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2oflPhx

Scarring alopecia with follicular papules in a father and his daughter

Clinical and Experimental Dermatology, EarlyView.


https://ift.tt/2Nokyjk

Behavior of Buccal Mucosal Squamous Cell Carcinoma: A Retrospective Study of 53 Carcinomas of This Anatomical Region

Cranial Maxillofac Trauma Reconstruction
DOI: 10.1055/s-0038-1668583

The main aim of the present report is to study the pattern of distribution of cervical metastasis in buccal mucosa cancer and to discuss the various therapeutic options available. Fifty-three patients with squamous cell carcinoma of the buccal mucosa treated with tumorectomy and selective neck dissection were included in the study. We also studied the relationship between specific pathological features and overall survival. Level Ib was the most affected level, followed by level IIa. T stage, N stage, N involvement tumor thickness, extracapsular spread (ECS), and vascular invasion were associated with poorer outcomes regarding overall survival (p < 0.001). Carcinoma of the buccal mucosa should be treated aggressively from the early stages. A large tumorectomy of the primary tumor is required to reduce the number of local recurrences. Moreover, we recommend performing a supraomohyoid neck dissection even in cT1N0 if there is a suspicion that the tumor thickness may be greater than 0.4 cm. The high risk of local recurrence obliges protection of the neck from a future cervical recurrence even in T1 small tumors. This could reduce the risk of cervical involvement during the follow-up and improve overall survival rates.
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Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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FDA Clears First Tretinoin Lotion for Acne (Altreno)

Tretinoin 0.05% lotion provided the proven efficacy of tretinoin in a generally well-tolerated formulation; skin dryness, pain, swelling, irritation, and peeling were reported in 4% of patients or less in clinical trials.
FDA Approvals

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