Anlotinib for the Treatment of Patients with Locally Advanced or Metastatic Medullary Thyroid Cancer

Thyroid, Ahead of Print.


https://ift.tt/2CIDQNJ

Fear of Recurrence and View of Life Affect Health-Related Quality of Life in Patients with Differentiated Thyroid Carcinoma: A Prospective Swedish Population-Based Study

Thyroid, Ahead of Print.


https://ift.tt/2qd4K95

Progestogen Hypersensitivity: presentation and natural history

To review the published medical literature on the clinical presentation, risk factors, and natural history of hypersensitivity reactions to progestogens.

https://ift.tt/2SjtNnI

Associations of unsafe, unsupportive and underdeveloped neighborhoods with atopic dermatitis in US children

Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting 12.97% of US children1 and 7% of US adults.2 Emotional factors, e.g. anxiety and stress, can also exacerbate AD flares and influence the course of disease.3,4 AD also poses a significant financial burden on society and negatively impacts patient and family quality of life.5,6 However, the relationship between childhood AD and neighborhood conditions has yet to be examined.

https://ift.tt/2z7hwKo

Co-existent TBX1 Mutation and Chromosomal 20q13.13-q13.2 Duplication in an Infant with Abnormal TREC Newborn Screening

An eight day old male, term infant of a diabetic mother with patent ductus arteriosus was transferred from an outlying facility for surgical management of truncus arteriosus (TA), coarctation of the aorta, hypoplastic aortic arch, and anomalous origin of the right subclavian artery. The newborn also had absent thymic shadow on chest radiograph, hypocalcemia, and abnormal newborn screening (NBS) for severe combined immunodeficiency (SCID) measuring T cell receptor rearrangement circles (TRECs); threshold cycle (Ct) was 36.86 (Normal <36).

https://ift.tt/2Sl15CU

Markers of systemic involvement and death in hospitalized cancer patients with severe cutaneous adverse reactions

Cancer patients have increased risk of severe cutaneous adverse reactions, without reliable biomarkers to identify predisposition for associated morbidity and mortality. In hospitalized cancer patients with morbilliform rash, elafin, IL-6, TNF-α were associated with mortality. IL-6, IL-10 were associated with drug-related systemic involvement. These biomarkers may guide future therapeutic research.

https://ift.tt/2PZSZhE

A Phase 2, Randomized Dose-Finding Study of Tapinarof (GSK2894512 Cream) for the Treatment of Plaque Psoriasis

Novel topical treatments for psoriasis have not been developed for many years. Tapinarof, a therapeutic AhR modulating agent, is a potential new treatment option for psoriasis patients. Tapinarof, delivered in a 1% cream, achieved ≥75% improvement in Psoriasis Area and Severity Index in 60% of patients treated once daily.

https://ift.tt/2O6XpRT