Exposure to Higher Concentrations of Particulate Matter Air Pollution Associated with Higher Incidence of Papillary Thyroid Cancer

xlomafota13 shared this article with you from Inoreader Exposure to Higher Concentrations of Particulate Matter Air Pollution Associated with Higher Incidence of Papillary Thyroid Cancer Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 9, Page 414-417, September 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thyroid Cancer Risk in Relation to Thyroid Nodule Location

xlomafota13 shared this article with you from Inoreader Thyroid Cancer Risk in Relation to Thyroid Nodule Location Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 9, Page 394-396, September 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thyrotropin-Receptor Antibody Positivity Does Not Correlate with Type 1 or Type 2 Amiodarone-Induced Thyrotoxicosis Phenotype

xlomafota13 shared this article with you from Inoreader Thyrotropin-Receptor Antibody Positivity Does Not Correlate with Type 1 or Type 2 Amiodarone-Induced Thyrotoxicosis Phenotype Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 9, Page 388-390, September 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hypothyroidism May Increase the Risk of Developing Dementia, at Least in Younger People

xlomafota13 shared this article with you from Inoreader Hypothyroidism May Increase the Risk of Developing Dementia, at Least in Younger People Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 9, Page 383-387, September 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Leaving the perfusion zones? Individualized flap design in 100 free DIEP and ms-TRAM flaps for autologous breast reconstruction using indocyanine green angiography

xlomafota13 shared this article with you from Inoreader Leaving the perfusion zones? Individualized flap design in 100 free DIEP and ms-TRAM flaps for autologous breast reconstruction using indocyanine green angiography Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Aug 17:S1748-6815(21)00377-6. doi: 10.1016/j.bjps.2021.08.002. Online ahead of print. ABSTRACT BACKGROUND: There is still no consensus regarding the ideal zoning in abdominal-based autologous breast reconstruction using free DIEP or ms-TRAM flaps. In particular, the perfusion pattern of the flap according to the number of perforators used and their location remains controversial. In this study, the perfusion of free DIEP and ms-TRAM flaps is assessed intraoperatively and analyzed with regard to different perfusion patterns. METHODS: A retrospective analysis of 100 free flaps for breast reconstruction was performed. Following complete flap harvest, we used indocyanine green angiography for perfusion analysis. By applying two different contour levels, DIEP flaps with lateral or medial perforators and ms-TRAM flaps were assessed for their respective perfusion patterns. RESULTS: No statistica lly significant differences were found in the size of the perfusion area between the different flap types when applying the contour level of 20% (p >0.05). For the contour level of 30%, however, statistically significant differences were found between DIEP flaps with medially or laterally located perforators (p = 0.038). Laterally or medially located perforators in DIEP flaps showed no significant differences in their ability to cross the midline (contour level 20%, p = 0.068; contour level 30%, p = 0.058). CONCLUSION: Considering the variability of the perfusion of the abdominal wall and the high sensitivity of indocyanine green angiography for their detection, the abdominal zonings play a minor role. By using intraoperative indocyanine green angiography, a precise and patient-specific free flap surgery for autologous breast reconstruction is possible independent of perforator location. PMID:34511387 | DOI:10.1016/j.bjps.2021.08.002 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Multiplex Thyroid-Specific Assay for Quantification of Circulating Thyroid Cell-Free RNA in Plasma of Thyroid Cancer Patients

xlomafota13 shared this article with you from Inoreader A Multiplex Thyroid-Specific Assay for Quantification of Circulating Thyroid Cell-Free RNA in Plasma of Thyroid Cancer Patients Via radioactive iodine Front Genet. 2021 Aug 25;12:721832. doi: 10.3389/fgene.2021.721832. eCollection 2021. ABSTRACT BACKGROUND: The standard of care for thyroid cancer management is thyroidectomy and adjuvant radioactive iodine (RAI). There is a paucity of clinical tool that quantifies residual thyroid volume reliably for precise adjuvant RAI dosing. Serum thyroglobulin (TG), tumour marker for thyroid cancer, takes 4 weeks for complete clearance due to its long half-life, and might be undetectable in 1 2% of structural disease patients. It detects recurrence with a sensitivity of 19-40%, mainly attributed to issue of TG antibody interference with TG immunometric assay. We hypothesise that the quantity of thyroid-specific cell-free RNA (cfRNA) is indicative of amount of thyroid tissues, and that during thyroid surgery, cfRNA levels decrease accordingly. METHODS: We identified 11 biologically significant and highly expressed thyroid-specific targets from Human Protein Atlas and literature. To assess for a fall in thyroid-specific cfRNA level, we recruited 16 patients undergoing thyroid surgery or RAI for malignant or benign thyroid disease, and tracked longitudinal trend of cfRNA. To assess the utility of cfRNA in detecting metastatic thyroid cancer, cfRNA of 11 patients at intermediate to high risk of recurrence was measured during surveillance and at time of clinical recurrence. RESULTS: The multiplex assay was capable of amplifying and quantifying multiple thyroid-spe cific genes in a single reaction. The selected targets were amplified successfully from RNA extracted directly from the thyroid (positive control), indicating that they were highly expressed within thyroid tissue. These cfRNAs were present in plasma, in amounts quantifiable using qRT-PCR. Four cfRNA transcripts (TPO, GFRA2, IVD, TG) fell post-treatment in more than 50% of cohort. The thyroid peroxidase (TPO) cfRNA fell post-therapy in 63% of cohort by 80%, as early as 1 day post-treatment, supporting the potential role as early indicator of remnant thyroid tissue volume. We demonstrated the clinical relevance of circulating TPO cfRNA by tracking temporal changes in setting of peri-treatment, recurrence, and TG Ab positive state. CONCLUSION: Using a multiplex pre-amplification approach, the TPO cfRNA was a potential biomarker that can track residual thyroid mass. It can be further optimised for quantification of thyroid volume to guide RAI doses and for detection of thyroid can cer recurrence. PMID:34512731 | PMC:PMC8425593 | DOI:10.3389/fgene.2021.721832 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Magnetic resonance imaging‐based radiogenomics analysis for predicting prognosis and gene expression profile in advanced nasopharyngeal carcinoma

xlomafota13 shared this article with you from Inoreader Magnetic resonance imaging‐based radiogenomics analysis for predicting prognosis and gene expression profile in advanced nasopharyngeal carcinoma Via Head & Neck Abstract Background To establish a radiomics nomogram for survival prediction and determine if genomic data were related to radiomics signature in advanced nasopharyngeal carcinoma (NPC). Methods Radiomics features were extracted from contrast-enhanced T1-weighted images (CE-T1WI) in 316 patients. A progression-free survival (PFS) nomogram was developed and validated by the combination of the radiomics signature and clinicopathologic factors. Whole transcriptomics sequencing was performed in pretreatment tumor samples; correlation of gene expression and radiomics signature was further investigated. Results A 24-feature-combined radiomics signature was highly correlated with PFS; its integration with clinical predictors showed good prediction performance in the training and the validation cohort (C-index: 0.80 and 0.73). A significant correlation was observed between certain gene expression and Rad-score, especially the mRNA expression of CDKL2, PLIN5, and SPAG1. Conclusion As a noninvasive method, the MRI-based radiomics signature might enable the pretreatment prediction of prognosis and gene expressions profile in advanced NPC. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.