Overcoming Vaccine Hesitancy Around Bell Palsy in Otolaryngology–Head and Neck Surgery—Reply

xlomafota13 shared this article with you from Inoreader Overcoming Vaccine Hesitancy Around Bell Palsy in Otolaryngology–Head and Neck Surgery—Reply Via JAMA Otolaryngology–Head & Neck Surgery Current Issue In Reply We thank the authors of the Letter to the Editor for stimulating further discussion. Tamaki et al explored the relationship between COVID-19 and the COVID-19 vaccine on Bell palsy (BP). Patients were counted as having Bell palsy if they received a diagnosis of International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) code G51.0. Granular patient-level data may be lacking in an analysis of this magnitude, and it was not possible to differentiate persistent or recurrent BP. Likewise, it is difficult to accurately quality check the accuracy of coding without the benefit of reviewing clinical data. We plan to expand on our work with further analysis. We agree that research using large databases may be at risk for misclassification. However, such databases can be an effective resource i n studying rare pathologies, especially in specific populations such as those who have had COVID-19 or received the COVID-19 vaccination. Our propensity score matched analysis suggests that rates of BP are higher in patients who are positive for COVID-19 and this incidence exceeds the reported incidence of BP with the COVID-19 vaccine. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Dermatomyositis With Carcinoma of Unknown Primary Disease

xlomafota13 shared this article with you from Inoreader Dermatomyositis With Carcinoma of Unknown Primary Disease Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This case report describes a unique case of dermatomyositis in a patient with carcinoma of unknown primary cancer in the head and neck in which neck dissection was a preceding treatment. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Falls Among People With Bilateral Vestibulopathy

xlomafota13 shared this article with you from Inoreader Falls Among People With Bilateral Vestibulopathy Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This review examines the current knowledge and applied methods on fall incidence, causes, and injuries in bilateral vestibulopathy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Secondary Syphilis Presenting as Recurrent Oral Mucocutaneous Lesions

xlomafota13 shared this article with you from Inoreader Secondary Syphilis Presenting as Recurrent Oral Mucocutaneous Lesions Via ear nose throat Ear Nose Throat J. 2022 Feb 10:1455613221078179. doi: 10.1177/01455613221078179. Online ahead of print. NO ABSTRACT PMID:35142533 | DOI:10.1177/01455613221078179 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma

xlomafota13 shared this article with you from Inoreader Irradiated fibroblasts increase interleukin-6 expression and induce migration of head and neck squamous cell carcinoma Via Head and neck squamous cell carcinoma by Shinsuke Suzuki, Satoshi Toyoma, Yohei Kawasaki, Takechiyo Yamada Background Cytotoxic effects of radiation play an important role in the treatment of head and neck cancer. However, irradiation is known to lead to the migration of various cancer cells, including those of head and neck cancer. Recently, fibroblasts in the cancer microenvironment have been reported to be involved in this mechanism. Nevertheless, the mechanism underlying migration of head and neck cancer cells remains unclear. Herein, we aimed to elucidate this migration mechanism induced by irradiation in terms of the interaction of head and neck cancer cells with fibroblasts. Methods We used the head and neck squamous cell carcinoma (HNSCC) cell lines SAS and FaDu as well as fibroblast cell lines. These cells were irradiated and their viability was compared. In fibroblasts, changes in interleukin-6 (IL-6) secretion caused by irradiation were measured by enzyme-linked immunosorbent assay (ELISA). The cell migration ability of cancer cells was evaluated via a migration assay using a semipermeable membrane. HNSCC cells were cocultured with irradiated and nonirradiated fibroblasts, and their migration ability under each condition was compared. We also examined the effect of IL-6 on the migration of HNSCC cells. Furthermore, to investigate the effect of fibroblast-derived IL-6 on the migration ability of HNSCC cells, we conducted a coculture study using IL-6 neutralizing antibody. Results Irradiation reduced the survival of HNSCC cells, whereas fibroblasts were resistant to irradiation. Irradiation also increased IL-6 secretion by fibroblasts. Migration of HNSCC cells was enhanced by coculture with fibroblasts and further enhanced by coculture with irradiated fibroblasts. We also confirmed that the migration of HNSCC cells was induced by IL-6. The enhanced migration of cancer cells caused by coculturing with fibroblasts was canceled by the IL-6 neutralizing antibody. Conclusion These results show that fibroblasts survive irradiation and indu ce the migration ability of HNSCC cells through increased secretion of IL-6. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cover Image

xlomafota13 shared this article with you from Inoreader Cover Image Via Head & Neck The cover image is based on the Education A novel method to reconstruct right recurrent laryngeal nerve by transforming into nonrecurrent laryngeal nerve: The end-to-free vagal laryngeal branch end anastomosis by Yu-Long Wang et al., https://doi.org/10.1002/hed.26942. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Facial landmark‐guided surface matching for image‐to‐patient registration with an RGB‐D camera

xlomafota13 shared this article with you from Inoreader Facial landmark‐guided surface matching for image‐to‐patient registration with an RGB‐D camera Via The International Journal of Medical Robotics and Computer Assisted Surgery Abstract Background Fiducial marker-based image-to-patient registration is the most common way in image-guided neurosurgery, which is labour-intensive, time consuming, invasive and error prone. Methods We proposed a method of facial landmark-guided surface matching for image-to-patient registration using an RGB-D camera. Five facial landmarks are localised from preoperative magnetic resonance (MR) images using deep learning and RGB image using Adaboost with multi-scale block local binary patterns, respectively. The registration of two facial surface point clouds derived from MR images and RGB-D data is initialised by aligning these five landmarks and further refined by weighted iterative closest point algorithm. Results Phantom experiment results show the target registration error is less than 3 mm when the distance from the camera to the phantom is less than 1000 mm. The registration takes less than 10 s. Conclusions The proposed method is comparable to the state-of-the-arts in terms of the accuracy yet more time-saving and non-invasive. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.