Improvement of osseointegration of Ti–6Al–4V ELI alloy orthodontic mini-screws through anodization, cyclic pre-calcification, and heat treatments

paythelady.61 shared this article with you from Inoreader Improvement of osseointegration of Ti–6Al–4V ELI alloy orthodontic mini-screws through anodization, cyclic pre-calcification, and heat treatments Via Progress in Orthodontics - Latest Articles Mini-screws are widely used as temporary anchorages in orthodontic treatment, but have the disadvantage of showing a high failure rate of about 10%. Therefore, orthodontic mini-screws should have high biocompa... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Does social support predict increased use of dental services in older men?

paythelady.61 shared this article with you from Inoreader Does social support predict increased use of dental services in older men? Via Australian Dental Journal Abstract Background Past research on social support and dental visits in older people has been limited by cross-sectional design, limited social support dimensions, and non-representative samples. Methods Data came from men with natural teeth completing Waves 3 and 4 of the Concord Health and Ageing in Men Project (CHAMP) in Sydney, Australia. The relationship between social support at Wave 3 (2011-2012) and at least one dental visit per year at Wave 4 (2014-2016) was examined by Poisson regression. Social support was measured by structural (marital status, living arrangements, family support, social interaction) and functional (social support satisfaction) domains. Results There were 673 men analysed. Structural and functional social support were not associated with the pattern of usual dental visits five years later in univariable or multivariable analyses. The only consistent significant factor was income source, with older men who had other sources of income more likely to regularly visit the dentist than older men solely reliant on the pension for income (PR: 1.31, 95% CI: 1.13 – 1.52). Conclusions We found no differences in the pattern of usual dental visits between older men with different levels and types of social support. For older Australian men, income source seems to be the most important determinant of regular dental visits. © 2022 Australian Dental Association View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Sclerostin in Periodontal Ligament: Homeostatic Regulator in Biophysical Force‐Induced Tooth Movement

paythelady.61 shared this article with you from Inoreader Sclerostin in Periodontal Ligament: Homeostatic Regulator in Biophysical Force‐Induced Tooth Movement Via Journal of Clinical Periodontology Abstract Aim This study elucidates the role of sclerostin in periodontal ligament (PDL) as a homeostatic regulator in biophysical force-induced tooth movement (BFTM). Materials and Methods BFTM was performed in rats, followed by microarray, immunofluorescence, in situ hybridization, and real-time PCR for detection and identification of the molecules. The periodontal space was analyzed via micro-computed tomography. Effects on osteoclastogenesis and bone resorption were evaluated in mouse bone marrow-derived cells. In vitro human PDL cells were subjected to biophysical forces. Results In the absence of BFTM, sclerostin was hardly detected in the periodontium except the PDL and alveolar bone in the furcation region and apex of the molar roots. However, sclerostin was upregulated in the PDL in vivo by adaptable force, which induced typical transfiguration without changes in periodontal space as well as in vitro PDL cells under compression and tension. In contrast, the sclerostin level was unaffected by heavy force, which caused severe degeneration of the PDL and narrowed periodontal space. Sclerostin inhibited osteoclastogenesis and bone resorption, which corroborates the accelerated tooth movement by the heavy force. Conclusions Sclerostin in PDL may be a key homeostatic molecule in the periodontium and a biological target for the therapeutic modulation of BFTM. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Effect of Selective Carboplatin-Induced Inner Hair Cell Loss on Temporal Integration in Chinchillas

paythelady.61 shared this article with you from Inoreader Effect of Selective Carboplatin-Induced Inner Hair Cell Loss on Temporal Integration in Chinchillas Via Latest Results for Journal of the Association for Research in Otolaryngology Abstract Integration of acoustic information over time is essential for processing complex stimuli, such as speech, due to its continuous variability along the time domain. In both humans and animals, perception of acoustic stimuli is a function of both stimulus intensity and duration. For brief acoustic stimuli, as duration increases, thresholds decrease by approximately 3 dB for every doubling in duration until stimulus duration reaches 500 ms, a phenomenon known as temporal integration. Although hearing loss and damage to outer hair cells (OHC) have been shown to alter temporal integration in some studies, the role of cochlear inner hair cells (IHC) on temporal integration is unknown. Because IHC transmit nearly all acoustic information to the central auditory system and are believed to code both intensity and timing information, these sensory cells likely play a critical role in temporal integration. To test the hypothesis that selective IHC loss degrades th e temporal integration function, behaviorally trained chinchillas were treated with carboplatin, a drug known to selectively destroy IHC with little to no effect on OHC in this species. Pure-tone thresholds were assessed across frequencies (1, 2, 4, 8, 12 kHz) as a function of signal duration (500, 100, 50, 10, and 5 ms). Baseline testing showed a significant effect of duration on thresholds. Threshold decreased as a function of increasing duration, as expected. Carboplatin treatment (75 mg/kg) produced a moderate to severe loss of IHC (45–85%) with little-to-no loss of OHC. Contrary to our hypothesis, post-carboplatin temporal integration thresholds showed no significant differences from baseline regardless of stimulus duration or frequency. These data suggest that few IHC are necessary for temporal integration of simple stimuli. Temporal integration may be sensitive to loss of OHC and loss of cochlear non-linearities but does not appear to be sensitive to selectiv e IHC loss. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Modification of an extended total temporomandibular joint replacement (eTMJR) classification system

paythelady.61 shared this article with you from Inoreader Modification of an extended total temporomandibular joint replacement (eTMJR) classification system Via British Journal of Oral and Maxillofacial Surgery The aims of this paper were to validate a modification of an extended total temporomandibular joint replacement (eTMJR) classification system and develop a classification schematic for ease of reference. High volume TMJ surgeons were asked to score 20 separate eTMJR devices using the updated classification system and inter-rater variability was calculated. Using the modified classification system developed, a Conger's kappa (k) coefficient of 0.53 was returned, suggesting moderate to good levels of agreement. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Allergische Reaktionen auf Bioimplantate

paythelady.61 shared this article with you from Inoreader Allergische Reaktionen auf Bioimplantate Via Latest Results for HNO Zusammenfassung Hintergrund Bioimplantate werden im HNO-Bereich vielfältig eingesetzt, am häufigsten in der rekonstruktiven Gesichtschirurgie, bei Cochleaimplantaten (CI), knochenverankerten Hörgeräten, PORP/TORP-Prothesen („partial ossicular replacement prosthesis", „total ossicular replacement prosthesis"), aber auch u. a. bei Paukendrainagen, Larynxkanülen, Stimmprothesen nach Laryngektomie und auch bei „HNO-nahen" Eingriffen als dentale Implantate in der Zahnmedizin. Methoden In einer Literatursuche wurde die Immunologie allergischer Reaktionen auf Bioimplantate analysiert und die vorhandene Evidenz ermittelt durch Recherchen in den Datenbanken Medline, PubMed sowie den nationalen und internationalen Studien- und Leitlinienregistern und der Cochrane Library. Es wurden Humanstudien berücksichtigt, die im Zeitraum bis einschließlich 12/2021 publiziert wurden. Ergebnis Basierend auf der internationalen Literatur und bisheriger Erfahrungen wird eine Übersicht über Allergien auf Bioimplantate in der HNO-Heilkunde gegeben. Schlussfolgerungen HNO-Ärzte sollten bei Einbringen allogener Materialien immer auch an die Möglichkeit allergischer Reaktionen denken – insbesondere auch, aber nicht nur – bei Bioimplantaten. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Spezielle Tumorentitäten im Kopf-Hals-Bereich

paythelady.61 shared this article with you from Inoreader Spezielle Tumorentitäten im Kopf-Hals-Bereich Via Latest Results for HNO Zusammenfassung Hintergrund In den letzten Jahren zeigt sich auch bei den speziellen Tumorentitäten im Kopf-Hals-Bereich eine zunehmende Studiendynamik. Bei den onkologischen Tagungen der American Society of Clinical Oncology (ASCO) und European Society for Medical Oncology (ESMO) 2021 wurden einige Studien vorgestellt, welche Änderungen im klinischen Alltag von Nasopharynxkarzinom, Speicheldrüsenkarzinom und Schilddrüsenkarzinom erwarten lassen. Ziel der Arbeit Zukünftige Therapieneuerungen spezieller HNO-Tumorentitäten wurden nach Sichtung der auf den Tagungen ASCO 2021 und ESMO 2021 präsentierten klinischen Studien abgeschätzt. Material und Methoden Es erfolgte eine systematische Analyse der präsentierten klinischen Phase-II- und -III-Studien zur Behandlung von Nasopharynx‑, Speicheldrüsen- und Schilddrüsenkarzinomen. Unter Berücksichtigung der aktuellen Therapiestandards wurden die Ergebnisse bezüglich ihrer potenziell klinischen Bedeutung eingeordnet. Ergebnisse und Diskussion In der kurativen Therapie von fortgeschrittenen Nasopharynxkarzinomen ist eine adjuvante Therapie mit Capecitabin nach primärer Radiochemotherapie als neuer Standard zu diskutieren. In der palliativen Therapie von Nasopharynxkarzinomen ist eine zunehmende Rolle von Immuntherapien zu prognostizieren. Rezidivierte/metastasierte Speicheldrüsenkarzinome werden bei Vorliegen molekularer angreifbarer Zielläsionen mit zielgerichteten Substanzen teilweise sehr effektiv behandelt. Immuntherapien spielen aktuell eine untergeordnete Rolle, scheinen sie nur bei wenigen Patienten mit Speicheldrüsenkarzinomen effektiv zu sein, die sich aktuell durch prädiktive Marker nicht verlässlich identifizieren lassen. Patienten mit radioiodrefraktären differenzierten Schilddrüsenkarzinom profitieren nach Versagen einer VEGFR-TKI-Therapie („vascular endothelial growth factor receptor", Tyrosinkinaseinhibitor) von einer Therapie mit dem Multi-TKI Cabozantinib. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.