! ORL via Alexandros G.Sfakianakis on Inoreader: Normal Taste Acceptance and Preference of PANX1 Knockout Mice

! ORL via Alexandros G.Sfakianakis on Inoreader

Normal Taste Acceptance and Preference of PANX1 Knockout Mice Aug 18th 2015, 00:08, by Tordoff, M. G., Aleman, T. R., Ellis, H. T., Ohmoto, M., Matsumoto, I., Shestopalov, V. I., Mitchell, C. H., Foskett, J. K., Poole, R. L. Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.

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