Radiography, Computed Tomography and Diagnostic Nasal Endoscopy (DNE)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Chronic rhinosinusitis is a common condition in medical practice. It is defined as inflammation of the mucosa of nose and paranasal sinuses, the fluids within these cavities, and/or the underlying bone that has been present with or without treatment for at least 12 weeks duration. In 1997, a detailed definition of the syndrome was […]
Huge Osteoclastoma of Hyoid Bone: A Case Report
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract Giant cell tumors (GCT) of hyoid bone are very rare, and only few individual cases were reported in literature. We present such a case of GCT arising from left cornu of hyoid bone. The patient underwent trans-cervical complete excision of the tumour. Postoperatively, patient did well without recurrence or metastasis for 2 years follow […]
Preventive Audiology: Screening for Hearing Impairment in Children Having Recurrent URTI
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract A late detection of hearing impairment in children can affect speech and language development. Otitis media with effusion (OME) associated with risk factors like recurrent upper respiratory tract infections (URTI) is considered the most common cause of silent hearing impairment among children. So this study was carried out to screen such at risk children […]
Audiological Profile in Primary Sjögren’s Syndrome in a Tertiary Care Setting and its Clinical Implic ations
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract This study aims to assess the frequency and the profile of hearing loss among patients with primary Sjögren’s syndrome in a tertiary care hospital in India and to look for an association between hearing loss and immunological parameters (anti-SSA antibody, anti-SSB antibody, anticardiolipin antibodies, complements C3 and C4). This prospective observational study was done […]
Study of Outcome of an Implanted Autologous Auricular Cartilage: A Preliminary Experimental Research in Rabbits
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Abstract To investigate the viability of the implanted crushed and uncrushed auricular cartilage graft with intact perichondrium with respect to macroscopic and microscopic parameters. Cartilage grafts from 8 white New Zealand rabbits were harvested from the right auricle, with intact perichondrial layers. There were two categories Pre implant and Post-implant and two types, mildly crushed […]
Launch of the Cancer and Obesity website
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
The International Agency for Research on Cancer (IARC) is pleased to announce the launch of the Cancer and Obesity website, which provides a variety of interactive tools for analysing and visualizing data on the estimated global burden of cancer in 2012 attributable to excess body weight (based on data previously published in the Lancet Oncology). […]
A Review on Breast Cancer Care in Africa
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Background: The global incidence of breast cancer (BC) is rising, especially in low- and middle-income countries. The purpose of this review is to summarize existing publications on BC care in Africa. Patients and Methods: A systematic search in MEDLINE and smaller databases was carried out to identify African studies on BC treatment, and an additional […]
PharmaNews
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Breast Care 2015;10:425-427 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/22drKRL via IFTTT
Editorial Board / Contents / Imprint / Guidelines for Authors
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Breast Care 2015;10:357-359 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/22drFh1 via IFTTT
Meetings and Conferences
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 26 δευτερόλεπτα
Breast Care 2015;10:429-430 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1k6ol50 via IFTTT
Frontal white matter changes and aggression in methamphetamine dependence
Frontal white matter changes and aggression in methamphetamine dependence: AbstractChronic methamphetamine (MA) use can lead to white matter (WM) changes and increased levels of aggression. While previous studies have examined WM abnormalities relating to cognitive impairment, associations between WM integrity and aggression in MA dependence remain unclear. Diffusion Tensor Imaging (DTI) was used to investigate WM changes in 40 individuals with MA dependence and 40 matched healthy controls. A region of interest (ROI) approach using tract based spatial statistics (TBSS) in FSL was p... περισσότερα »
Distance as a Barrier to Cancer Diagnosis and Treatment
Distance as a Barrier to Cancer Diagnosis and Treatment: Review of the Literature: The burden of travel from a patient’s residence to health care providers is an important issue that can influence access to diagnosis and treatment of cancer. Although several studies have shown that the travel burden can result in delays in diagnosis and treatment of many common cancers, its role appears underestimated in the treatment of patients in clinical practice. Therefore, we performed a review of the published data on the role of travel burden influencing four items: delay of diagnosis, adeq... περισσότερα »
Novel immunotherapies in lymphoid malignancies
Nature Reviews Clinical Oncology 13, 25 (2016). doi:10.1038/nrclinonc.2015.187 Authors: Connie Lee Batlevi, Eri Matsuki, Renier J. Brentjens & Anas Younes The success of the anti-CD20 monoclonal antibody rituximab in the treatment of lymphoid malignancies provided proof-of-principle for exploiting the immune system therapeutically. Since the FDA approval of rituximab in 1997, several novel strategies that harness …
Circadian rhythm influences genome-wide transcriptional responses to 131 I in a tissue-specific manner
Circadian rhythm influences genome-wide transcriptional responses to 131 I in a tissue-specific manner in mice: Abstract Background Circadian variation of gene expression is often neglected when ionizing radiation-induced effects are studied, whether in animal models or in cell culture. This study characterized diurnal variation of genome-wide transcriptional regulation and responses of potential biomarkers and signature …
Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle
Publication date: Available online 17 December 2015 Source:Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics Author(s): Olga E. Karpicheva, Armen O. Simonyan, Nadezhda V. Kuleva, Charles S. Redwood, Yurii S. Borovikov from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UIRlNu via IFTTT
Skin cancer: Nicotinamide reduces new skin cancer risk
Nature Reviews Clinical Oncology 13, 4 (2016). doi:10.1038/nrclinonc.2015.199 Author: Peter Sidaway Newly-published findings of a phase III trial, published in the New England Journal of Medicine, reveal that oral nicotinamide (vitamin B3) reduces the risk of new cancers in patients with a previous history of nonmelanoma skin cancers (NMSC), and is a safe (Source: Nature …
SEOM guidelines for the management of Malignant Melanoma 2015
SEOM guidelines for the management of Malignant Melanoma 2015: Abstract All melanoma patients must be confirmed histologically and resected according to Breslow. Sentinel node biopsy must be done when tumor is over 1 mm or if less with high-risk factors. Adjuvant therapy with interferon must be offered for patients with high-risk melanoma and in selected …
CD14 is a key organizer of microglial responses to CNS infection and injury
Microglia, innate immune cells of the CNS, sense infection and damage through overlapping receptor sets. Toll-like receptor (TLR) 4 recognizes bacterial lipopolysaccharide (LPS) and multiple injury-associated factors. We show that its co-receptor CD14 serves three non-redundant functions in microglia. First, it confers an up to 100-fold higher LPS sensitivity compared to peripheral macrophages to enable …
Population genetic testing for cancer susceptibility: founder mutations to genomes
Nature Reviews Clinical Oncology 13, 41 (2016). doi:10.1038/nrclinonc.2015.173 Authors: William D. Foulkes, Bartha Maria Knoppers & Clare Turnbull The current standard model for identifying carriers of high-risk mutations in cancer-susceptibility genes (CSGs) generally involves a process that is not amenable to population-based testing: access to genetic tests is typically regulated by health-care providers on the …
Carotid intima-medial thickness as a marker of radiation-induced carotid atherosclerosis
Carotid intima-medial thickness as a marker of radiation-induced carotid atherosclerosis: Arterial thickening is a precursor to atherosclerosis. Carotid intima-medial thickness (CIMT), a measure of arterial thickening, is a validated surrogate for prediction of cerebrovascular events. This study investigates CIMT as an early marker of radiation-induced carotid artery damage. from #Med Blogs by Alexandros G.Sfakianakis via …
What can we learn from oncology surgical trials?
Nature Reviews Clinical Oncology 13, 55 (2016). doi:10.1038/nrclinonc.2015.176 Authors: Serge Evrard, Pippa McKelvie-Sebileau, Cornelis van de Velde, Bernard Nordlinger & Graeme Poston Conducting high-quality prospective clinical trials in surgical oncology remains a challenge, and many seemingly well-designed trials lack this high quality because of inadequate recruitment accrual, lack of clinician interest, or evolution of treatment …
Comparison of weekly versus triweekly cisplatin delivered concurrently with radiation therapy in patients with locally advanced nasopharyngeal cancer: A multicenter randomized phase II trial (KCSG-HN10-02)
Comparison of weekly versus triweekly cisplatin delivered concurrently with radiation therapy in patients with locally advanced nasopharyngeal cancer: A multicenter randomized phase II trial (KCSG-HN10-02): Triweekly delivery of cisplatin concurrent with a course of radiation therapy (RT) has been the standard regimen for treatment of locally advanced nasopharyngeal carcinoma (NPC) despite a high level of …
Sonographic features of keratoacanthoma. May ultrasound be a useful tool to differentiate it from squamous cell carcinoma?
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/22cQGcc via IFTTT
POEMS syndrome initially presenting with acral dermatitis
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1ZfpHKs via IFTTT
Balancing Safety and Efficacy of EGFR Inhibitors in Patients With HNSCC
Balancing Safety and Efficacy of Epidermal Growth Factor Receptor Inhibitors in Patients With Squamous Cell Carcinoma of the Head and Neck: The epidermal growth factor receptor (EGFR) is overexpressed in more than 80% of squamous cell cancers of the head and neck (SCCHN). An evolving understanding of the role of EGFR in tumorigenesis has made the receptor an important therapeutic target in SCCHN. Several EGFR inhibitors (EGFRIs) are active in SCCHN, and their use is associated with improvement in progression-free survival and overall survival in various treatment settings. Neverthe...περισσότερα »
Ramosetron Versus Ondansetron in Combination With Aprepitant and Dexamethasone for the Prevention of Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting
Ramosetron Versus Ondansetron in Combination With Aprepitant and Dexamethasone for the Prevention of Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Randomized Phase III Trial, KCSG PC10-21: Background. A combination of serotonin receptor (5-hydroxytryptamine receptor type 3) antagonists, NK-1 receptor antagonist, and steroid improves the complete response (CR) of chemotherapy-induced nausea and vomiting (CINV) in cancer patients. Ramosetron’s efficacy in this triple combination regimen has not been investigated. This prospective, multicenter, single-blind... περισσότερα »
Abdominal Fat Distribution on Prognosis After Esophagectomy for Esophageal Squamous Cell Carcinoma
Clinical Impact of Abdominal Fat Distribution on Prognosis After Esophagectomy for Esophageal Squamous Cell Carcinoma: Abstract BackgroundExcessive visceral fat may promote cancer development and progression because of metabolic derangements. The purpose of this study was to clarify the impact of abdominal fat distribution on patient prognosis after esophagectomy for esophageal squamous cell carcinoma (ESCC). MethodsComputed tomography volumetry was performed in 150 patients who underwent curative esophagectomy for ESCC between 2012 and 2013. Visceral fat area (VFA) and subcuta... περισσότερα »
Therapeutic strategy for chylous leakage after esophagectomy: focusing on lymphangiography using lipiodol
Therapeutic strategy for chylous leakage after esophagectomy: focusing on lymphangiography using lipiodol: Abstract BackgroundConservative treatments are usually attempted for the management of post-esophagectomy chylous leakage. However, surgical intervention may be needed when the chylous leakage cannot be stopped using conservative treatments. For the therapeutic management of refractory chylous leakage, it is important to identify the leakage sites when deciding if surgical intervention is required. MethodsNine patients underwent lymphangiography for the treatment of refra... περισσότερα »
p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma
Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma: AbstractP38β, p38γ, and p38δ have been sporadically and scarcely reported to be involved in the carcinogenesis of cancers, compared with p38α isoform. However, little has been known regarding their clinicopathological significance and biological roles in esophageal squamous cell carcinoma (ESCC). Expression status of p38β, p38γ, and p38δ was assayed using immunohistochemistry with ESCC tissue microarray; ensuing clinicopathological significance was statistically ...περισσότερα »
CD14 is a key organizer of microglial responses to CNS infection and injury
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Microglia, innate immune cells of the CNS, sense infection and damage through overlapping receptor sets. Toll-like receptor (TLR) 4 recognizes bacterial lipopolysaccharide (LPS) and multiple injury-associated factors. We show that its co-receptor CD14 serves three non-redundant functions in microglia. First, it confers an up to 100-fold higher LPS sensitivity compared to peripheral macrophages to enable […]
Impaired Toll-like receptor 2-mediated Th1 and Th17/22 cytokines secretion in human peripheral blood mononuclear cells from patients with atopic dermatitis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Background: Impaired Toll-like receptor 2 (TLR2) function has been associated with the pathogenesis of atopic dermatitis (AD). However, there are only few studies reporting on the TLR2-induced immunological responses of circulating leucocytes of AD patients. We thus investigated the expression and secretion of Th1, Th2 and Th17/22 cytokines triggered by TLR2 ligands in human peripheral […]
Comparative Study on the Roles of the Number of Accelerations and Rotation Angle in the Treatment Maneuvers for Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Aims: This study aims to investigate the roles of the number of accelerations and rotation angle in the treatment of posterior semicircular canal benign paroxysmal positional vertigo (PC-BPPV). Methods: We enrolled 344 patients with unilateral PC-BPPV. Of these, 167 patients in the simple-step maneuver (SSM) group were accelerated twice and rotated 120° per step, whereas […]
IJMS, Vol. 16, Pages 30190-30203: Comparative Transcriptome Analysis of Genes Involved in GA-GID1-DELLA Regulatory Module in Symbiotic and Asymbiotic Seed Germination of Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae) is an endangered medicinal plant in China, also called “King Medicine”. Due to lacking of sufficient nutrients in dust-like seeds, orchid species depend on mycorrhizal fungi for seed germination in the wild. As part of a conservation plan for the species, research on seed germination is necessary. However, the molecular […]
IJMS, Vol. 16, Pages 30321-30341: FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
cFLIP (cellular FLICE-like inhibitory protein) is structurally related to caspase-8 but lacks proteolytic activity due to multiple amino acid substitutions of catalytically important residues. cFLIP protein is evolutionarily conserved and expressed as three functionally different isoforms in humans (cFLIPL, cFLIPS, and cFLIPR). cFLIP controls not only the classical death receptor-mediated extrinsic apoptosis pathway, but also […]
IJMS, Vol. 16, Pages 30223-30250: Applications of Micro-Fourier Transform Infrared Spectroscopy (FTIR) in the Geolog ical Sciences—A Review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Fourier transform infrared spectroscopy (FTIR) can provide crucial information on the molecular structure of organic and inorganic components and has been used extensively for chemical characterization of geological samples in the past few decades. In this paper, recent applications of FTIR in the geological sciences are reviewed. Particularly, its use in the characterization of geochemistry […]
IJMS, Vol. 16, Pages 30309-30320: Human Anti-Oxidation Protein A1M—A Potential Kidney Protection Agent in Peptide Receptor Radionuclide Therapy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 6 δευτερόλεπτα
Peptide receptor radionuclide therapy (PRRT) has been in clinical use for 15 years to treat metastatic neuroendocrine tumors. PRRT is limited by reabsorption and retention of the administered radiolabeled somatostatin analogues in the proximal tubule. Consequently, it is essential to develop and employ methods to protect the kidneys during PRRT. Today, infusion of positively charged […]
A novel therapeutic approach against B-cell non-Hodgkin’s lymphoma through co-inhibition of Hedgehog signaling pathway and autophagy
A novel therapeutic approach against B-cell non-Hodgkin’s lymphoma through co-inhibition of Hedgehog signaling pathway and autophagy: AbstractB-cell non-Hodgkin’s lymphoma (B-NHL) is one of the most common types of cancer in the world, with half of the patients dying due to the resistance or tolerance against the treatment. Thus, a novel therapeutic approach for B-NHL treatment was urgently needed. In this study, we investigated the potential of co-inhibition of Hedgehog signaling pathway (Hh) and autophagy in B-NHL therapy. We reported that vismodegib, an inhibitor of Hedgehog sig... περισσότερα »
Mechanisms of Esophageal Adenocarcinoma Formation
and Approaches to Chemopreventive Intervention via Seminars in Oncology Publication date: Available online 15 December 2015 *Source:*Seminars in Oncology Author(s): Ellen Richmond, Asad Umar The incidence of esophageal adenocarcinoma (EAC), a debilitating and highly lethal malignancy, has risen dramatically over the past 40 years in the U.S. and other Western countries.1 To reverse this trend, EAC prevention and early detection efforts by clinicians, academic researchers and endoscope manufacturers have targeted Barrett’s esophagus (BE), the widely accepted EAC precursor lesion. Data ...περισσότερα »
Evaluation of a wireless audio streaming accessory to improve mobile telephone performance of cochlear implant users
Volume 55, Issue 2, February 2016, pages 75-82<br>10.3109/14992027.2015.1095359<br>Jace Wolfe from #Audiology via ola Kala on Inoreader http://ift.tt/1T5TtxG via IFTTT
Ipilmumab and cranial radiation in metastatic melanoma patients
Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review: Abstract BackgroundIpilimumab improves survival in metastatic melanoma patients. This population frequently develops brain metastases, which have been associated with poor survival and are often treated with radiation. Therefore, outcomes following ipilimumab and radiation are of interest, especially given case reports and animal studies suggest combined treatment may generate abscopal responses outside the radiation field. FindingsWe reviewed sixteen consecutive melanoma patients who rec... περισσότερα »
Relationship between CK19 expression, deregulation of normal keratinocyte differentiation pattern and high risk-human papilloma virus infection in oral and oropharyngeal squamous cell carcinoma
Relationship between CK19 expression, deregulation of normal keratinocyte differentiation pattern and high risk-human papilloma virus infection in oral and oropharyngeal squamous cell carcinoma: Abstract BackgroundSimple epithelial keratins appear early during embryonic development and are expressed in non-stratified, ductal and pseudo-stratified epithelial tissues. CK19, the lowest molecular weight keratin, is also expressed in basal layer of squamous epithelia of mucosal surfaces. Previous studies have shown that High Risk-Human Papilloma Virus (HR-HPV) epithelial infection indu...περισσότερα »
FDA Approves Cobimetinib as Part of Drug Combination for Advanced Melanoma
FDA Approves Cobimetinib as Part of Drug Combination for Advanced Melanoma: On November 10, the Food and Drug Administration (FDA) approved the use of cobimetinib (Cotellic™) in combination with vemurafenib (Zelboraf®) to treat patients with metastatic melanoma. Both drugs block targets that act at different steps in the same signaling pathway, the mitogen-activated protein kinase, or MAPK, pathway. Cobimetinib inhibits the activity of an enzyme known as MEK, and vemurafenib inhibits the enzyme BRAF.
Angiotensin-(1-7) Decreases Cell Growth and Angiogenesis of Human Nasopharyngeal Carcinoma Xenografts
Angiotensin-(1-7) Decreases Cell Growth and Angiogenesis of Human Nasopharyngeal Carcinoma Xenografts: Angiotensin-(1-7) [Ang-(1-7)] is an endogenous, heptapeptide hormone acting through the Mas receptor (MasR), with anti-proliferative and anti-angiogenic properties. Recent studies have shown that Ang-(1-7) has an anti-proliferative action on lung adenocarcinoma cells and prostate cancer cells. In this study, we report that MasR levels were significantly upregulated in nasopharyngeal carcinoma (NPC) specimens and NPC cell lines. Viral vector-mediated expression of Ang-(1-7) dramati...περισσότερα »
Surgical techniques to prevent reflux esophagitis in proximal gastrectomy reconstructed by esophagogastrostomy with preservation of the lower esophageal sphincter, pyloric and celiac branches of the vagal nerve, and reconstruction of the new His angle for early proximal gastric cancer
Surgical techniques to prevent reflux esophagitis in proximal gastrectomy reconstructed by esophagogastrostomy with preservation of the lower esophageal sphincter, pyloric and celiac branches of the vagal nerve, and reconstruction of the new His angle for early proximal gastric cancer: Abstract PurposeThis article describes the surgical techniques to prevent reflux esophagitis (RE) after proximal gastrectomy reconstructed by esophagogastrostomy (PGE) preservation of the lower esophageal sphincter (LES) and both pyloric and celiac branches of the vagal nerve (PCVN), and reconstruct... περισσότερα »
AHNAK is downregulated in melanoma, predicts poor outcome, and may be required for the expression of functional cadherin-1.
AHNAK is downregulated in melanoma, predicts poor outcome, and may be required for the expression of functional cadherin-1.: The aim of this study was to further our understanding of the transformation process by identifying differentially expressed proteins in melanocytes compared with melanoma cell lines. Tandem mass spectrometry incorporating iTRAQ reagents was used as a screen to identify and comparatively quantify the expression of proteins in membrane-enriched samples isolated from primary human melanocytes or three melanoma cells lines. Real-time PCR was used to validate sign... περισσότερα »
Circadian rhythm influences genome-wide transcriptional responses to 131 I in a tissue-specific manner
Circadian rhythm influences genome-wide transcriptional responses to 131 I in a tissue-specific manner in mice: Abstract BackgroundCircadian variation of gene expression is often neglected when ionizing radiation-induced effects are studied, whether in animal models or in cell culture. This study characterized diurnal variation of genome-wide transcriptional regulation and responses of potential biomarkers and signature genes in normal mouse tissues at 24 h after i.v. administration of 131I. MethodsFemale BALB/c nude mice were i.v. injected with 90 kBq 131I at 9:00 a.m., 12:00...περισσότερα »
SEOM guidelines for the management of Malignant Melanoma 2015
SEOM guidelines for the management of Malignant Melanoma 2015: AbstractAll melanoma patients must be confirmed histologically and resected according to Breslow. Sentinel node biopsy must be done when tumor is over 1 mm or if less with high-risk factors. Adjuvant therapy with interferon must be offered for patients with high-risk melanoma and in selected cases radiotherapy can be added. Metastatic melanoma treatment is guided by mutational BRAF status. BRAF wild type patients must receive anti-PD1 therapy and BRAF mutated patients BRAF/MEK inhibitors or anti-PD1 therapy. Up to 10 ye... περισσότερα »
Carotid intima-medial thickness as a marker of radiation-induced carotid atherosclerosis
Carotid intima-medial thickness as a marker of radiation-induced carotid atherosclerosis: [image: gr1.sml] Arterial thickening is a precursor to atherosclerosis. Carotid intima-medial thickness (CIMT), a measure of arterial thickening, is a validated surrogate for prediction of cerebrovascular events. This study investigates CIMT as an early marker of radiation-induced carotid artery damage.
Comparison of weekly versus triweekly cisplatin delivered concurrently with radiation therapy in patients with locally advanced nasopharyngeal cancer: A multicenter randomized phase II trial (KCSG-HN10-02)
Comparison of weekly versus triweekly cisplatin delivered concurrently with radiation therapy in patients with locally advanced nasopharyngeal cancer: A multicenter randomized phase II trial (KCSG-HN10-02): [image: gr1.sml] Triweekly delivery of cisplatin concurrent with a course of radiation therapy (RT) has been the standard regimen for treatment of locally advanced nasopharyngeal carcinoma (NPC) despite a high level of concern regarding treatment-related complications. We conducted a randomized phase II study to compare weekly and triweekly cisplatin delivery during RT with ... περισσότερα »
Transitions in the Prophylaxis, Treatment and Care of Patients with Venous Thromboembolism
Transitions in the Prophylaxis, Treatment and Care of Patients with Venous Thromboembolism: Abstract IntroductionPatients experience numerous transitions, including changes in clinical status, pharmacologic treatment and prophylaxis, and progression through the physical locations of their healthcare setting as they advance through a venous thromboembolism (VTE) clinical experience. This review provides an overview of these transitions and highlights how they can impact clinical care. MethodsMajor public resources (PubMed, MEDLINE, and Google Scholar) were searched using variou... περισσότερα »
Effect of Thiocyanate on Iodine Status of Pregnant Women
Effect of Thiocyanate on Iodine Status of Pregnant Women: AbstractThe aim of this study was to assess the thyroid status of pregnant women on the basis of biochemical indicators and to evaluate the potential risk of developing iodine deficiency as a result of tobacco smoke exposure by assessing the association between urinary thiocyanate levels and the manifestation of iodine deficiency. The study included 219 pregnant women from the town of Plovdiv and Plovdiv District in Southern Bulgaria. The levels of urinary iodine, thyroid-stimulating hormone (TSH), free thyroxine (FT4), and ... περισσότερα »
B-Cell Disorders and Curcumin
B-Cell Disorders and Curcumin: Clinical studies with patients with early hematological malignancies (ie, monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, or stage 0/1 chronic lymphocytic leukemia) suggest that early intervention with curcumin, derived from the spice turmeric, may lead to prolonged survival and delay in progressive disease in some of these patients.
Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models identify second line combination therapies
Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models identify second line combination therapies: Purpose: To test second-line personalized medicine combination therapies, based on genomic and proteomic data, in patient-derived xenograft (PDX) models. Methods: We established 12 PDX from BRAF inhibitor progressed melanoma patients. Following expansion, PDX were analyzed using targeted sequencing and reverse phase protein arrays (RPPA). By using multi-arm pre-clinical trial designs, we identified efficacious precision medicine approaches. Resul...περισσότερα »
A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma
A single nucleotide polymorphism in the Epstein-Barr virus genome is strongly associated with a high risk of nasopharyngeal carcinoma: Epstein-Barr virus (EBV) commonly infects the general population and has been associated with nasopharyngeal carcinoma (NPC), which has a high incidence in certain regions. This study aimed to address how EBV ...
Selective A 3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity
Selective A 3 adenosine receptor agonist protects against doxorubicin-induced cardiotoxicity: Abstract PurposeDoxorubicin (DOX) is an effective anticancer drug; however, its clinical use is limited by its cardiotoxic effect. Adenosine was proved to mediate anti-inflammatory effects and protected from myocardial ischemia/reperfusion injury. So the present work was designed to examine the effectiveness of a selective A3 adenosine receptor agonist (Cl-IB-MECA) in DOX-induced cardiotoxicity and to elucidate the underlying mechanisms via studying its effect on different oxidative stres... περισσότερα »
Utility of epirubicin-incorporating micelle tagged with anti-tissue factor antibody clone with no anticoagulant effect
Utility of epirubicin-incorporating micelle tagged with anti-tissue factor antibody clone with no anticoagulant effect: Abstract Tissue factor (TF), an initiator of the extrinsic blood coagulation cascade, is over-expressed in different types of cancer. TF over-expression is also known as a poor prognostic factor in pancreatic cancer. We recently developed anti-TF antibody (clone1849)-conjugated epirubicin-incorporating micelles (NC-6300), and reported that this anti-TF1849-NC-6300 demonstrated enhanced antitumor activity against TF-high-expressed human pancreatic cancer cells, whe... περισσότερα »
Relationships between neurocognitive functioning, mood, and quality of life in patients with temporal lobe glioma
Relationships between neurocognitive functioning, mood, and quality of life in patients with temporal lobe glioma: Abstract Objective While neurocognitive functioning (NCF) and mood disturbance share a relationship with health-related quality of life (HRQOL), few studies have examined relationships between these constructs in glioma patients prior to treatment. Methods Newly diagnosed patients with glioma in the left (N = 73; 49% glioblastoma) or right (N = 30; 57% glioblastoma) temporal lobe completed neuropsychological testing and self-report measures of HRQOL (Functional Assessm... περισσότερα »
Infectious Mononucleosis, Other Infections, and Prostate-Specific Antigen Concentration as a Marker of Prostate Involvement During Infection
Infectious Mononucleosis, Other Infections, and Prostate-Specific Antigen Concentration as a Marker of Prostate Involvement During Infection: ABSTRACT Although Epstein-Barr virus has been detected in prostate tissue, no associations have been observed with prostate cancer in the few studies conducted to date. One possible reason for these null findings may be use of cumulative exposure measures that do not inform the timing of infection, i.e., childhood versus adolescence/early-adulthood when infection is more likely to manifest as infectious mononucleosis (IM). We sought to determi... περισσότερα »
Early experience with X-ray magnetic resonance fusion for low-flow vascular malformations in the pediatric interventional radiology suite
Early experience with X-ray magnetic resonance fusion for low-flow vascular malformations in the pediatric interventional radiology suite: AbstractThis technical innovation describes our experience using an X-ray magnetic resonance fusion (XMRF) software program to overlay 3-D MR images on real-time fluoroscopic images during sclerotherapy procedures for vascular malformations at a large pediatric institution. Five cases have been selected to illustrate the application and various clinical utilities of XMRF during sclerotherapy procedures as well as the technical limitations of thi... περισσότερα »
Expression of CD47 on human cancer cells profoundly increases tumor metastasis
Expression of mouse CD47 on human cancer cells profoundly increases tumor metastasis in murine models: Abstract BackgroundMany commonly used xenograft tumor models do not spontaneously metastasize to distant organs following subcutaneous or orthotopic implantation, limiting their usefulness in preclinical studies. It is generally believed that natural killer cells are the key component of the innate immune system in determining tumor metastatic potential in xenograft models. However, recent studies suggest that macrophages may play an important role, as resident macrophages can el...περισσότερα »
The impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy
The impact of the cumulative dose of cisplatin during concurrent chemoradiotherapy on the clinical outcomes of patients with advanced-stage nasopharyngeal carcinoma in an era of intensity-modulated radiotherapy: Abstract BackgroundThe impact of cumulative dose of cisplatin on clinical outcomes of nasopharyngeal carcinoma (NPC) patients who received intensity-modulated radiotherapy (IMRT) was evaluated. MethodsThis study included 491 consecutive patients with histologically confirmed NPC who were treated with concurrent chemoradiotherapy with IMRT. The patients were divided into... περισσότερα »
Choroidal metastases from thymic carcinoma during pregnancy
Choroidal metastases from thymic carcinoma during pregnancy: Case Report: Abstract BackgroundRare sites of metastases, atypical symptoms and paraneoplastic syndromes are often neglected or misinterpreted, especially when they represent early symptoms of an underlying malignant disease. Hence, an interdisciplinary approach to these patients is essential to avoid tumor progression and metastatic spread in order to provide curative treatment options to the patients. We here report the case of a young woman presenting with visual loss which led to diagnosis of a thymic carcinoma. C...περισσότερα »
Epirubicin: a new entry in the list of fetal cardiotoxic drugs?
Epirubicin: a new entry in the list of fetal cardiotoxic drugs? Intrauterine death of one fetus in a twin pregnancy. Case report and review of literature: Abstract BackgroundCurrent knowledge indicate that epirubicin administration in late pregnancy is almost devoid of any fetal cardiotoxicity. We report a twin pregnancy complicated by breast cancer in which epirubicin administration was causatively linked to the death of one twin who was small for gestational age (SGA) and in a condition of oligohydramnios and determined the onset of a transient cardiotoxicity of the surviving fe... περισσότερα »
Preoperative ultrasonography and serum thyroid-stimulating hormone on predicting central lymph node metastasis in thyroid nodules as or suspicious for papillary thyroid microcarcinoma
Preoperative ultrasonography and serum thyroid-stimulating hormone on predicting central lymph node metastasis in thyroid nodules as or suspicious for papillary thyroid microcarcinoma: AbstractThe purpose of this study was to describe the ultrasonography (US) image features and preoperative thyroid-stimulating hormone (TSH) level in patients with thyroid nodules read as or suspicious for papillary thyroid microcarcinoma (PTMC) on US-guided fine-needle aspiration biopsy (US-FNAB) and to identify the risk factors for central lymph node metastasis (CLNM) that can guide surgical strate...περισσότερα »
Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer
Invariant NKT cells are resistant to circulating CD15+ myeloid-derived suppressor cells in patients with head and neck cancer: Summary Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature and progenitor myeloid cells with an immunosuppressive role in various types of cancer, including head and neck squamous cell carcinoma (HNSCC). However, the effect on the host immune system, especially on invariant NKT (iNKT) cells with potent anti-tumor activity, remains unclear. In this study, we investigated the effects of circulating MDSC subsets on the periphera...περισσότερα »
Multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis
Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis: Abstract Multi-wall carbon nanotubes (MWCNTs) are flexible fibrous nanomaterial with high electrical and thermal conductivity. However, MWCNT 50 nm in diameter causes malignant mesothelioma (MM) in rodents, and thus the International Agency of Research on Cancer designated them as a possible human carcinogen. The molecular mechanism by which MWCNT causes MM is scarcely known. To elucidate the carcinogenic mechanisms of MWCNT in mesothelial cells, we used a variety of lysa... περισσότερα »
Identification of genomic mutations associated with clinical outcomes of induction chemotherapy in patients with head and neck squamous cell carcinoma
Identification of genomic mutations associated with clinical outcomes of induction chemotherapy in patients with head and neck squamous cell carcinoma: Abstract PurposeWe performed deep sequencing of target genes in head and neck squamous cell carcinoma (HNSCC) tumors to identify somatic mutations that are associated with induction chemotherapy (IC) response. MethodsPatients who were diagnosed with HNSCC were retrospectively identified. Patients who were treated with IC were divided into two groups: good responders and poor responders by tumor response and progression-free sur...περισσότερα »
As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma
As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma: Abstract BackgroundCysteine/histidine-rich 1 (CYHR1) was first discovered in a yeast two-hybrid screen with murine galectin-3, and no previous reports have described a relationship between the CYHR1 gene and human cancer. The current study evaluated the role and significance of CYHR1 in esophageal cancer. MethodsThe human esophageal squamous cell carcinoma (ESCC) cell line TE-8 and the CYHR1 knock-down cell line TE-8/small interfering (si)... περισσότερα »
Induction Chemotherapy With Cisplatin, 5-fluorouracil, {+/-} Docetaxel for Larynx Preservation
Long-term Results of a Multicenter Randomized Phase III Trial of Induction Chemotherapy With Cisplatin, 5-fluorouracil, {+/-} Docetaxel for Larynx Preservation: Background: The purpose of GORTEC 2000–01 was to compare the long-term efficacy and safety of induction chemotherapy with cisplatin (P) and 5-fluorouracil (F) with or without docetaxel (T) for larynx preservation. Methods: Operable patients with untreated stage III or IV larynx or hypopharynx invasive squamous cell carcinoma who required total laryngectomy were randomly assigned to three cycles of induction chemotherapy wit...περισσότερα »
Intrathecal Methotrexate After Developing Subacute Neurotoxicity
Rechallenging With Intrathecal Methotrexate After Developing Subacute Neurotoxicity in Children With Hematologic Malignancies: [image: cover.gif?v=1&s=86de6547f0744d5a90482061] Methotrexate is associated with neurologic side effects. It is recommended that patients who developed neurotoxicity be rechallenged with methotrexate, but little is known about the safety of this approach. We performed a chart review to identify patients who received high-dose or intrathecal (IT) methotrexate. Twenty-one of 298 patients (7%) experienced neurologic symptoms attributed to methotrexate trea...περισσότερα »
Neurocognitive effects of proton radiation therapy
Neurocognitive effects of proton radiation therapy in adults with low-grade glioma: AbstractTo understand neurocognitive effects of proton radiation therapy (PRT) in patients with low-grade glioma, we evaluated 20 patients who received this therapy prospectively and over 5 years with a comprehensive neuropsychological battery. 20 patients were evaluated at baseline and at yearly intervals for up to 5 years with a battery of neuropsychological measures that assessed intellectual, attention, executive, visuospatial and memory functions as well as mood and functional status. We evalua... περισσότερα »
Socioeconomic status, human papillomavirus, and overall survival in HNSCC
Socioeconomic status, human papillomavirus, and overall survival in head and neck squamous cell carcinomas in Toronto, Canada via ScienceDirect Publication: Cancer Epidemiology (open access) Publication date: February 2016 *Source:*Cancer Epidemiology, Volume 40 Author(s): K.P. Chu, S. Habbous, Q. Kuang, K. Boyd, M. Mirshams, F.-F. Liu, O. Espin-Garcia, W. Xu, D. Goldstein, J. Waldron, B. O’Sullivan, S.H. Huang, G. Liu BackgroundDespite universal healthcare in some countries, lower socioeconomic status (SES) has been associated with worse cancer survival. The influence of SES on head a... περισσότερα »
Changes in demography and in the risk factors to the predicted pattern of cancer mortality
Contribution of changes in demography and in the risk factors to the predicted pattern of cancer mortality among Spanish women by 2022 via ScienceDirect Publication: Cancer Epidemiology (open access) Publication date: February 2016 *Source:*Cancer Epidemiology, Volume 40 Author(s): Ramon Clèries, Maria Buxó, José M. Martínez, Josep A. Espinàs, Tadeusz Dyba, Josep M. Borràs BackgroundChanges in the burden of cancer mortality are expected to be observed among Spanish women. We predict those changes, in Spain, for breast cancer (BC), colorectal cancer (CRC), lung cancer (LC) and pancreati... περισσότερα »
Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes
Gene fusions in soft tissue tumors: Recurrent and overlapping pathogenetic themes: Gene fusions have been described in approximately one-third of soft tissue tumors (STT); of the 142 different fusions that have been reported, more than half are recurrent in the same histologic subtype. These gene fusions constitute pivotal driver mutations, and detailed studies of their cellular effects have provided important knowledge about pathogenetic mechanisms in STT. Furthermore, most fusions are strongly associated with a particular histotype, serving as ideal molecular diagnostic markers. ... περισσότερα »
Assessment of sural flap microcirculation
: Which position maintains the optimal perfusion? via British Association of Plastic Surgeons Publication date: Available online 17 December 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): Jens Rothenberger, Sabrina Krauss, Manuel Held, Christian Tschumi, Afshin Rahmanian-Schwarz, Hans-Eberhard Schaller, Patrick Jaminet BackgroundLimb elevation is a common practice to reduce edema and to increase venous drainage. Considering the anatomy of the sural flap with retrograde perfusion and hence potentially difficult blood outflow, the best angle to positioning... περισσότερα »
Risk factors for hypertrophic skin scarring
Currently known risk factors for hypertrophic skin scarring: A review via British Association of Plastic Surgeons Publication date: Available online 17 December 2015 *Source:*Journal of Plastic, Reconstructive & Aesthetic Surgery Author(s): L. Butzelaar, M.M.W. Ulrich, A.B. Mink van der Molen, F.B. Niessen, R.H.J. Beelen ObjectiveTo provide an overview of risk factors for hypertrophic scarring.BackgroundHypertrophic skin scarring remains a problem in medicine and causes considerable morbidity. Despite extensive research on this topic, the precise mechanism of excessive scarring is still...περισσότερα »
The PRISMA Checklist
Optimizing Quality of Systematic Reviews With the PRISMA Checklist by Ishii LE. via JAMA Facial Plastic Surgery Online First Optimizing Quality of Systematic Reviews With the PRISMA Checklist by Ishii LE. via JAMA Facial Plastic Surgery Online First In this issue of JAMA Facial Plastic Surgery, Lee et al describe adherence to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist for systematic reviews reported in plastic surgery. This study is timely because the number of systematic reviews in the facial plastic surgery literature continues to in... περισσότερα »
Defects in the buccal bone
Influence of preservation of the alveolar ridge on delayed implants after extraction of teeth with different defects in the buccal bone via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 17 December 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Chaoyuan Pang, Yuxiang Ding, Kaijin Hu, Hongzhi Zhou, Ruifeng Qin, Rui Hou Our aim was to evaluate the influence of preservation of the alveolar ridge on delayed implants with different defects in the buccal bone. We enrolled 60 patients who had one posterior mandibular tooth extr...περισσότερα »
Fibrin glue combined with OK-432 and bleomycin
Percutaneous sclerotherapy of arteriovenous malformations of the face using fibrin glue combined with OK-432 and bleomycin after embolisation via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 17 December 2015 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Xiao-peng Zhao, Zhi-quan Huang, Wei-liang Chen, You-yuan Wang, Zhao-yu Lin Congenital arteriovenous malformations (AVM) in the maxillofacial region are rare, but potentially life-threatening, vascular lesions. Here we review our experience of 13 patients with AVM of the faci...περισσότερα »
K6, K8, K16, K17, K19, Maspin, Syndecan-1 (CD138), α-SMA and Ki-67 in ameloblastoma and ameloblastic carcinoma
Immunohistochemical expression of K6, K8, K16, K17, K19, Maspin, Syndecan-1 (CD138), α-SMA and Ki-67 in ameloblastoma and ameloblastic carcinoma: diagnostic and prognostic correlations via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: Available online 17 December 2015 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Author(s): Rima A. Safadi, Basma F. Quda, Huda M. Hammad ObjectiveTo identify cut off values of markers that correlate with the histopathologic diagnosis of ameloblastic carcinoma (AC) and/or the increased recurrence ... περισσότερα »
Excision and Fat Grafting of Nasal Tip Dermoid Cysts Through an Open Rhinoplasty Approach.
Excision and Fat Grafting of Nasal Tip Dermoid Cysts Through an Open Rhinoplasty Approach.: Nasal tip dermoid cysts that are present in pediatric patients can be complicated by mass effect causing compression and distortion of underlying cartilaginous structures. The purpose of this report is to describe a single surgeon's technique and results of nasal tip dermoid cyst excision in pediatric patients through an open rhinoplasty approach followed by tip reconstruction and immediate fat grafting. A series of 3 pediatric patients presented with 1 to 1.5 cm nasal tip dermoid cysts that ...περισσότερα »
To evaluate the utility of 10 warning signs questionnaire in assessment of cognitive function among elderly people
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Sunil Kumar Raina, Vishav Chander Journal of Neurosciences in Rural Practice 2016 7(1):168-170 Introduction: Routine screening of high-risk elderly people for early cognitive impairment using mini-mental state examination (MMSE) and its modifications may be constrained by demographic and other variables. Warning signs (as reported by family/caregivers) may be a useful alternative. The present data analysis […]
The role of imaging in Hirayama disease
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Rosa Cortese, Isabella Laura Simone Journal of Neurosciences in Rural Practice 2016 7(1):5-6 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1IcZsQP via IFTTT
Commentary
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Soubhagya Ranjan Tripathy Journal of Neurosciences in Rural Practice 2016 7(1):131-132 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1k6i4q7 via IFTTT
Results of early cranial decompression as an initial approach for damage control therapy in severe traumatic brain injury in a hospital with limited resources
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
José D Charry, Andrés M Rubiano, Christine V Nikas, Juan C Ortíz, Juan C Puyana, Nancy Carney, P David Adelson Journal of Neurosciences in Rural Practice 2016 7(1):7-12 Introduction: Severe traumatic brain injury (sTBI) is a disease that generates significant mortality and disability in Latin America, and specifically in Colombia. The purpose of this study […]
Neurological manifestations of Graves’ disease: A case report and review of the literature
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Swayamsidha Mangaraj, Arun Kumar Choudhury, Binoy Kumar Mohanty, Anoj Kumar Baliarsinha Journal of Neurosciences in Rural Practice 2016 7(1):153-156 Graves’ disease (GD) is characterized by a hyperfunctioning thyroid gland due to stimulation of the thyroid-stimulating hormone receptor by autoantibodies directed against it. Apart from thyrotoxicosis, other clinical manifestations include ophthalmopathy, dermopathy, and rarely acropachy. GD […]
Hindi translation and evaluation of psychometric properties of Craig Hospital Inventory of Environmental Factors instrument in spinal cord injury subjects
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Sandeep Soni, Shefali Walia, Majumi Mohamad Noohu Journal of Neurosciences in Rural Practice 2016 7(1):13-22 Introduction: The Craig Hospital Inventory of Environmental Factors instrument (CHIEF) is one of the few tools to assess the environmental barriers. The purpose of this study was to translate long and short CHIEF into Hindi language, and to determine its […]
Subdural hematoma presenting as trigeminal neuralgia: A case report
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 33 δευτερόλεπτα
Sandro Zambito Marsala, Michele Pistacchi, Manuela Gioulis Journal of Neurosciences in Rural Practice 2016 7(1):179-181 from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1k6i2hK via IFTTT
Socio-demographic disadvantage and distant summary stage of cancer at diagnosis—A population-based study in New South Wales
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
Publication date: February 2016 Source:Cancer Epidemiology, Volume 40 Author(s): Hanna E. Tervonen, Richard Walton, David Roder, Hui You, Stephen Morrell, Deborah Baker, Sanchia Aranda BackgroundPast studies generally indicate that socio-demographic disadvantage is associated with lower cancer survival but evidence of an association with stage of cancer at diagnosis has been less consistent. This study examines […]
History of gonorrhea and prostate cancer in a population-based case–control study in Mexico
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
Publication date: February 2016 Source:Cancer Epidemiology, Volume 40 Author(s): Ruth Argelia Vázquez-Salas, Luisa Torres-Sánchez, Lizbeth López-Carrillo, Martín Romero-Martínez, Hugo A. Manzanilla-García, Carlos Humberto Cruz-Ortíz, Fernando Mendoza-Peña, Miguel Ángel Jiménez-Ríos, Francisco Rodríguez-Covarrubias, Narciso Hernández-Toríz, Othón Moreno-Alcázar We evaluated the association between a history of sexually transmitted diseases (STDs) and the risk for prostate cancer (PC) among […]
Socioeconomic status, human papillomavirus, and overall survival in head and neck squamous cell carcinomas in Toronto, Canada
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
Publication date: February 2016 Source:Cancer Epidemiology, Volume 40 Author(s): K.P. Chu, S. Habbous, Q. Kuang, K. Boyd, M. Mirshams, F.-F. Liu, O. Espin-Garcia, W. Xu, D. Goldstein, J. Waldron, B. O’Sullivan, S.H. Huang, G. Liu BackgroundDespite universal healthcare in some countries, lower socioeconomic status (SES) has been associated with worse cancer survival. The influence of […]
Low protein A20 in minor salivary glands is associated with lymphoma development in primary Sjögren’s syndrome
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
In conclusion, we found absent or weak protein A20 immunoreactivity in MSGs of patients with pSS with lymphomas. This finding indicates that protein A20 down‐regulation in lymphocytes might be a mechanism underlying lymphoma‐genesis in patients with pSS. This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 […]
Characterization of Th17 and FoxP3+ Treg cells in pediatric psoriasis patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PdcyyK via IFTTT
The phenotypic and functional features of human M2 macrophages generated under low serum conditions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Pdcy1S via IFTTT
Liver resident macrophages (Kupffer cells) share several functional antigens in common with endothelial cells
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PdcwXF via IFTTT
Dapsone hypersensitivity syndrome not related to G6PD deficiency
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with […]
Ovarian vein thrombosis in a polytrauma patient
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
A young mother presented to a major trauma centre following a road traffic collision. Her admission CT traumagram demonstrated liver and renal lacerations, spinal and pelvic fractures with no abnormalities of the ovarian veins. Her inpatient course was uncomplicated other than a sustained, isolated raised C reactive protein. CT of the abdomen 1 week after […]
Cryptococcal eosinophilic meningitis in a patient with sarcoidosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 36 δευτερόλεπτα
A 51-year-old African-American man with underlying pulmonary, hepatic and splenic sarcoidosis, reported a 3-day history of headache, neck stiffness and photophobia. He was not using medication for chronic sarcoidosis. Physical examination was significant for nuchal rigidity. Lumbar puncture revealed marked eosinophilia in the cerebrospinal fluid, which, on further analysis, demonstrated a positive cryptococcal antigen. HIV […]
Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV positive oropharyngeal cancer
Regional control is preserved after dose de-escalated radiotherapy to involved lymph nodes in HPV positive oropharyngeal cancer: Patients with HPV positive oropharyngeal squamous cell carcinoma (OPSCC) are known to have a significantly more favorable prognosis than their HPV negative counterparts [1]. The substantially better prognosis of these patients has created new challenges in determining the optimal treatment approach. While concurrent chemoradiotherapy to 70Gy is presently the standard of care for OPSCC, this recommendation is based on randomized clinical trials which were d...περισσότερα »
Genome-wide association studies (GWAS) for the Oral Metagenome
A New Association for the Oral Metagenome: Abstract Genome-wide association studies (GWAS) have been used extensively to catalogue human gene variation in health and disease. This approach can be extended to metagenome-wide association studies (MGWAS), in which changes in the total microbial gene content at a body site are correlated with a particular disease. Although MGWAS has been employed widely to identify key associations between the gut metagenome and disease, relatively few MGWAS have analysed the oral microbiota and these have generally focussed on dental caries and period... περισσότερα »
Psychological disorders and oral lichen planus
Psychological disorders and oral lichen planus: matched case-control study and literature review: Abstract Objective Oral lichen planus (OLP) may be linked to psychological disorders. This study investigated psychological factors associated with OLP. Methods A case-control study with incident OLP case patients and age-gender-socioeconomic status-matched controls, recruited from among relatives, accompanying persons, and departmental staff, investigated psychological traits using the Psychological General Well-Being Index-Short form. Common factor analysis was used to generate a set ...περισσότερα »
Clonazepam for symptom remission in burning mouth syndrome
Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta-analysis by Yuan Cui, Hao Xu, Fangman Chen, Jinli Liu, Lu Jiang, Yu Zhou, Qianming Chen via Oral Diseases Abstract Objectives Clonazepam has been used in the treatment of burning mouth syndrome (BMS) for several decades. We conducted a meta-analysis to investigate the efficacy of clonazepam in the treatment of BMS. Methods We conducted a search of the PubMed, Medline, EMBASE, Web of Science (TS), and the Cochrane Library databases for relevant studies that met our eligibility criteria (up to Sept... περισσότερα »
Hypertonic saline solution for management of parotid fistula
: A case report via ScienceDirect Publication: Journal of Oral Biology and Craniofacial Research Publication date: Available online 17 December 2015 *Source:*Journal of Oral Biology and Craniofacial Research Author(s): Ajaz A. Shah, Nahida Dar, Mohammed Israr Ul Khaliq, Tajamul Hakeem The management of parotid fistulae has been unsatisfactory in the past, and numerous methods of treatment with varying success and morbidity have been described. A case of parotid fistula caused by damage to glandular elements during a transparotid approach for a subcondylar fracture reduction is reporte...περισσότερα »
IJMS, Vol. 16, Pages 30251-30268: Short- and Long-Term Effects of Prenatal Exposure to Iron Oxide Nanoparticles: Influence of Surface Charge and Dose on Developmental and Reproductive Toxicity
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Iron oxide nanoparticles (NPs) are commonly utilized for biomedical, industrial, and commercial applications due to their unique properties and potential biocompatibility. However, little is known about how exposure to iron oxide NPs may affect susceptible populations such as pregnant women and developing fetuses. To examine the influence of NP surface-charge and dose on the developmental […]
IJMS, Vol. 16, Pages 30269-30308: Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Liver disease is highly prevalent in the world. Oxidative stress (OS) and inflammation are the most important pathogenetic events in liver diseases, regardless the different etiology and natural course. N-acetyl-l-cysteine (the active form) (NAC) is being studied in diseases characterized by increased OS or decreased glutathione (GSH) level. NAC acts mainly on the supply of […]
IJMS, Vol. 16, Pages 30204-30222: MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
MicroRNAs represent ~22 nt long endogenous small RNA molecules that have been experimentally shown to regulate gene expression post-transcriptionally. One main interest in miRNA research is the investigation of their functional roles, which can typically be accomplished by identification of mi-/mRNA interactions and functional annotation of target gene sets. We here present a novel method […]
IJMS, Vol. 16, Pages 30181-30189: Randomized Controlled Trial of Darbepoetin α Versus Continuous Erythropoietin Receptor Activator Injected Subcutaneously Once Every Four Weeks in Patients with Chronic Kidney Disease at the Pre-Dialysis Stage
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Continuous erythropoietin receptor activator (CERA) seems to maintain a stable hemoglobin (Hb) level because its half-life is longer than darbepoetin α (DA). Twenty chronic kidney disease (CKD) patients at the pre-dialysis stage who had been administered DA for over 24 weeks were randomly assigned to receive subcutaneous CERA or DA once every four weeks during […]
IJMS, Vol. 16, Pages 30342: Retraction: X. Ma et al. Hybrid Endovascular Repair in Aortic Arch Pathologies: A Retros pective Study. Int. J. Mol. Sci. 2010, 11, 4687–4696
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
We have been made aware that the figures and experimental data reported in the title paper [1] are duplicated in another publication by P. Bergeron [2]. […] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lWnF4a via IFTTT
Why a Science Writer Celebrates Winter Solstice
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
In the darkest time of year, religious rituals can help even non-believers see that life is a miracle.
Congratulations to ecancer Board Member Prof Cristina Stefan, first woman to take reins of @AORTIC_AFRICA https://t.co/ItRRRVTwvI
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Congratulations to ecancer Board Member Prof Cristina Stefan, first woman to take reins of @AORTIC_AFRICA https://t.co/ItRRRVTwvI from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/677830513516814340 via IFTTT
Exploring Change Processes in School-Based Mentoring for Bullied Children
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Abstract We examined change processes associated with the school-based, lunchtime mentoring of bullied children. We used data from a one-semester open trial of Lunch Buddy (LB) mentoring (N = 24) to examine changes in bullied children’s lunchtime peer relationships. We also tested whether these changes predicted key outcomes (i.e., peer victimization, social preference) post-mentoring. Results […]
Galena Biopharma to Sell ZuplenzB. (ondansetron) Oral Soluble Film, Completing … – CNNMoney
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Proactive Investors USA & Canada Galena Biopharma to Sell ZuplenzB. (ondansetron) Oral Soluble Film, Completing … CNNMoney “With the sale of Zuplenz, we are now fully focused on advancing our high value cancer immunotherapy clinical development pipeline, which is led by our Phase 3 product candidate, NeuVax™.” Mizuho Securities is acting as exclusive advisor to […]
Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol Biol. 2016;1386:135-179 Authors: Eberhardt M, Lai X, Tomar N, Gupta S, Schmeck B, Steinkasserer A, Schuler G, Vera J Abstract The understanding of the immune response is right now at the center of biomedical research. There are growing expectations […]
Superficial circumflex iliac artery perforator flap
imaging, anatomy, and clinical applications in oral maxillofacial reconstruction via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 18 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Yue He, Shufang Jin, Zhuowei Tian, Zao Fang, Chunyue Ma, Xiaofeng Tao, Yixin Zhang, Weiliu Qiu, Zhiyuan Zhang, Chenping Zhang PurposeTo assess the feasibility of superficial circumflex iliac artery perforator (SCIP) flap for oral maxillofacial reconstruction and evaluate computed tomography angiography (CTA) and color Doppler ...περισσότερα »
Zygomatic buttress block bone graft
A clinical study of the outcomes and complications associated with zygomatic buttress block bone graft for limited preimplant augmentation procedures via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 17 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Andreas Sakkas, Alexander Schramm, Winter Karsten, Nils-Claudius Gellrich, Frank Wilde PurposeThe aim of this study was to evaluate the possibility of using the zygomatic buttress as an intraoral bone harvesting donor site and determine the safety of this har...περισσότερα »
Bone-impacted fibular free flap
Bone-impacted fibular free flap: Long-term dental implant success and complications compared to traditional fibular free tissue transfer: Abstract Background The purpose of this study was to compare complications and dental implant success between the bone-impacted fibula free flap (BIFFF) and the traditional fibular free flap used in mandibular and midface reconstruction. Methods Retrospective review of all patients undergoing BIFFF or traditional fibular free flap reconstruction from 2001 to 2009 was undertaken. Complications related to the BIFFF and traditional fibular free flap s... περισσότερα »
Panitumumab monotherapy as second-line treatment in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
PRISM: Phase 2 trial with panitumumab monotherapy as second-line treatment in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: Abstract Background Panitumumab Regimen In Second-line Monotherapy of Head and Neck Cancer (PRISM) trial evaluated the safety and efficacy of panitumumab as second-line monotherapy in patients with recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN). Methods This was an open-label, single-arm, multicenter trial that enrolled patients with progressive disease or intolerance to first-line systemic ch...περισσότερα »
Tumor volume as a predictor of survival in human papillomavirus–positive oropharyngeal cancer
Tumor volume as a predictor of survival in human papillomavirus–positive oropharyngeal cancer: Abstract Background Increasing evidence exists that tumor volume may be a superior prognostic model than traditional TNM staging. It has been observed that oropharyngeal squamous cell carcinoma (oropharyngeal SCC) in the setting of human papillomavirus (HPV) positivity have a greater propensity for cystic nodal metastases, and, thus, presumably larger volume with relatively smaller primary tumors. The influence of HPV status on the predictive value of tumor volume is unknown. Methods Fift...περισσότερα »
Effect of training frequency on the learning curve on the da Vinci Skills Simulator
Effect of training frequency on the learning curve on the da Vinci Skills Simulator: Abstract Background The purpose of this study was to evaluate the effect of training on the performance outcome with the da Vinci Skills Simulator. Methods Forty novices were enrolled in a prospective training curriculum. Participants were separated into 2 groups. Group 1 performed 4 training sessions and group 2 had 2 training sessions over a 4-week period. Five exercises were performed 3 times consecutively. On the last training day, a new exercise was added. Results A significant skills gain from... περισσότερα »
Challenges in the Management of Laryngeal Stenosis
Challenges in the Management of Laryngeal Stenosis: AbstractLaryngeal stenosis is one of the most complex and challenging problems in the field of head and neck surgery. The management involves a multidisciplinary approach with multiple complex procedures. In this study we discuss our experience of laryngeal stenosis with regards to patient characteristics, cause and management. A retrospective analysis of 35 patients of laryngeal stenosis treated at a tertiary care centre was evaluated. Inclusion criteria were all patients with laryngeal stenosis who required surgical intervention...περισσότερα »
Results of Hearing Outcome According to the Alloplastic Ossicular Prosthesis Materials
Results of Hearing Outcome According to the Alloplastic Ossicular Prosthesis Materials: AbstractThe aim of this study is to compare the functional results and extrusion rates according to the type of ossciular alloplastic prosthesis. In this study, a retrospective analysis was performed. Sixty-one patients were involved in partial ossicular replacement (POR) cases and 70 patients were involved in total osscicular replacement (TOR) cases. In POR cases, Plastipore was used in 21 cases, hydroxyapatite in 20 cases, and titanium in 20 cases. In TOR cases, Plastipore was used in 20 cases... περισσότερα »
Low Grade Fibromyxoid Sarcoma in Oral Cavity
Low Grade Fibromyxoid Sarcoma in Oral Cavity: A Rare Case Report: AbstractLow-grade fibromyxoid sarcoma (LGFMS) is a rare, low-grade malignant soft tissue neoplasm. It is a distinctive variant of fibrosarcoma with a high metastasizing potential and sometimes long interval between tumor presentation and metastasis. It may present in any part of body. However in the region of the head and neck, they are seldom seen and hence easily misdiagnosed. We report the case of an 18-year-old female who developed a large mass in the left oral cavity. The tumor was excised. On pathology evaluati...περισσότερα »
Extracranial Head and Neck Schwannomas
Extracranial Head and Neck Schwannomas: Our Experience: AbstractSchwannomas are benign neoplasms of the peripheral nerves originating in the Schwann cells. They are rare and usually solitary, with clearly delimited capsules. They occur in the head and neck region in only 25 % of the cases, and may be associated with Von Recklinghausen’s disease. Schwannomas are always a diagnostic dilemma as they are asymptomatic for long time and histopathology is the gold standard for diagnosis. The present study retrospectively analysed data of 4 patients with schwannomas and reviewed the litera... περισσότερα »
To Avoid Stunning, Give Treatment Doses of Radioiodine-131 within Three Days after Completing the Diagnostic Scan or Wait Seven Days
To Avoid Stunning, Give Treatment Doses of Radioiodine-131 within Three Days after Completing the Diagnostic Scan or Wait Seven Days: Clinical Thyroidology Dec 2015, Vol. 27, No. 12: 341-343. [image: Free first page]
Thyroid Cancer Survivors Are at Increased Risk for Breast Cancer
Thyroid Cancer Survivors Are at Increased Risk for Breast Cancer: Clinical Thyroidology Dec 2015, Vol. 27, No. 12: 329-331. [image: Free first page]
Does Subclinical Thyroid Dysfunction Contribute to the Frailty Syndrome in Men over 65 Years of Age?
Frailty syndrome From Wikipedia, the free encyclopedia *Frailty* is a common geriatric syndrome that embodies an elevated risk of catastrophic declines in health and function among older adults. Frailty is a condition associated with ageing, and it has been recognized for centuries. As described by Shakespeare in *As You Like It*, "the sixth age shifts into the lean and slipper’d pantaloon, with spectacles on nose and pouch on side, his youthful hose well sav’d, a world too wide, for his shrunk shank…". The shrunk shank is a result of loss of muscle with aging. It is also a marker ... περισσότερα »
Maternal Subclinical Hypothyroidism as Well as Maternal Hyperthyroidism in Early Pregnancy May Increase the Risk of Offspring Having Difficulty with Mathematics
Maternal Subclinical Hypothyroidism as Well as Maternal Hyperthyroidism in Early Pregnancy May Increase the Risk of Offspring Having Difficulty with Mathematics: Clinical Thyroidology Dec 2015, Vol. 27, No. 12: 332-335. [image: Free first page]
Ablative Doses of Radioiodine Do Not Cause Permanent Leukopenia or Thrombocytopenia
Ablative Doses of Radioiodine Do Not Cause Permanent Leukopenia or Thrombocytopenia: Clinical Thyroidology Dec 2015, Vol. 27, No. 12: 344-345.
Subacute Thyroiditis Masquerading as Hyperemesis Gravidarum in Early Pregnancy
Subacute Thyroiditis Masquerading as Hyperemesis Gravidarum in Early Pregnancy: Clinical Thyroidology Dec 2015, Vol. 27, No. 12: 346-350. [image: Free first page]
Molecules, Vol. 20, Pages 22703-22717: Phenolic Assesment of Uncaria tomentosa L. (Cat’s Claw): Leaves, Stem, Bark and Wood Extracts
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
The phenolic composition of extracts from Uncaria tomentosa L. from different regions of Costa Rica was studied using advanced analytical techniques such as UPLC/TQ-ESI-MS and 13C-NMR. Samples from leaves, stems, bark and wood (n = 22) were subjected to extraction to obtain phenolic and alkaloid extracts, separately. Comparatively, higher values of total phenolic content were observed for leaves, stems and bark (225–494 gallic acid equivalents/g) than for wood extracts (40–167 gallic acid equivalents/g). A total of 32 non-flavonoid and flavonoid compounds were identified in the ph... περισσότερα »
Molecules, Vol. 20, Pages 22691-22702: Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3–2-carbamothioylhydrazonolup-20(29)-en-28-oic acid. from #Medicine via ola Kala on Inoreader http://ift... περισσότερα »
IJERPH, Vol. 12, Pages 16110-16123: A Spatial Framework to Map Heat Health Risks at Multiple Scales
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
In the last few decades extreme heat events have led to substantial excess mortality, most dramatically in Central Europe in 2003, in Russia in 2010, and even in typically cool locations such as Vancouver, Canada, in 2009. Heat-related morbidity and mortality is expected to increase over the coming centuries as the result of climate-driven global increases in the severity and frequency of extreme heat events. Spatial information on heat exposure and population vulnerability may be combined to map the areas of highest risk and focus mitigation efforts there. However, a mismatch in ... περισσότερα »
IJERPH, Vol. 12, Pages 16096-16109: Classifying Natural Waters with the Forel-Ule Colour Index System: Results, Applications, Correlations and Crowdsourcing
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 53 δευτερόλεπτα
Societal awareness of changes in the environment and climate has grown rapidly, and there is a need to engage citizens in gathering relevant scientific information to monitor environmental changes due to recognition that citizens are a potential source of critical information. The apparent colour of natural waters is one aspect of our aquatic environment that is easy to detect and an essential complementary optical water quality indicator. Here we present the results and explore the utility of the Forel-Ule colour index (FUI) scale as a proxy for different properties of natural wa... περισσότερα »
Unmet Needs at the Time of Emergency Department Discharge
[image: cover.gif?v=1&s=b888515e15f9341aaa636a46] Abstract Objectives Emergency department (ED) discharge requires conveying critical information in a time-limited and distracting setting. Limited health literacy may put patients at risk of incomplete comprehension, but the relationship between discharge communication needs and health literacy has not been well defined. The goal of this study was to characterize the variation in needs and preferences regarding the ED discharge process by health literacy, and identify novel ideas for process improvement from parents and patients. ...περισσότερα »
Endocrine disorders among long-term survivors of childhood head and neck rhabdomyosarcoma
Publication date: February 2016 *Source:*European Journal of Cancer, Volume 54 Author(s): S.C. Clement, R.A. Schoot, O. Slater, J.C. Chisholm, C. Abela, A.J.M. Balm, M.W. van den Brekel, W.B. Breunis, Y.C. Chang, R. Davila Fajardo, D. Dunaway, E. Gajdosova, M.N. Gaze, S. Gupta, B. Hartley, L.C.M. Kremer, M. van Lennep, G.A. Levitt, H.C. Mandeville, B.R. Pieters, P. Saeed, L.E. Smeele, S.D. Strackee, C.M. Ronckers, H.N. Caron, H.M. van Santen, J.H.M. Merks PurposeHead and neck rhabdomyosarcoma (HNRMS) survivors are at increased risk of developing pituitary dysfunction as an adverse e... περισσότερα »
Perioperative treatment and radical cystectomy for bladder cancer – a population based trend analysis of 10,338 patients in the Netherlands
Publication date: February 2016 *Source:*European Journal of Cancer, Volume 54 Author(s): Tom J.N. Hermans, Elisabeth E. Fransen van de Putte, Simon Horenblas, Valery Lemmens, Katja Aben, Michiel S. van der Heijden, Laurens V. Beerepoot, Rob H. Verhoeven, Bas W.G. van Rhijn BackgroundIn Europe, population-based data concerning perioperative treatment (PT) and radical cystectomy (RC) are lacking. We assessed temporal trends in PT (neoadjuvant chemotherapy [NAC], neoadjuvant radiotherapy [NAR], adjuvant chemotherapy [AC], adjuvant radiotherapy [AR]) and RC in the Netherlands and ident... περισσότερα »
Is there any benefit to adding adjuvant chemotherapy after concurrent chemoradiotherapy for nasopharyngeal carcinoma?
Publication date: Available online 17 December 2015 *Source:*European Journal of Cancer Author(s): Marie Yan, Alexander Kumachev, Kelvin K.W. Chan from Cancer via ola Kala on Inoreader http://ift.tt/1Jg6dfI via IFTTT
A phase II trial to evaluate the efficacy of fostamatinib in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL)
Publication date: February 2016 *Source:*European Journal of Cancer, Volume 54 Author(s): Ian W. Flinn, Nancy L. Bartlett, Kristie A. Blum, Kirit M. Ardeshna, Ann S. LaCasce, Christopher R. Flowers, Andrei R. Shustov, Kenneth S. Thress, Patrick Mitchell, Fred Zheng, Jeffrey M. Skolnik, Jonathan W. Friedberg PurposeTo assess the safety and efficacy of fostamatinib in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).Experimental designRelapsed or refractory DLBCL patients originally received the oral spleen tyrosine kinase inhibitor, fostamatinib in a two-arm...περισσότερα »
Risk factors for keratinocyte skin cancer in patients diagnosed with melanoma, a large retrospective study
Publication date: January 2016 *Source:*European Journal of Cancer, Volume 53 Author(s): Pablo Espinosa, Ruth M. Pfeiffer, Zaida García-Casado, Celia Requena, Maria Teresa Landi, Rajiv Kumar, Eduardo Nagore BackgroundMelanoma survivors are at an increased risk of developing other malignancies, including keratinocyte skin cancer (KSC). While it is known that many risk factors for melanoma also impact risk of KSC in the general population, no previous study has investigated risk factors for KSC development in melanoma patients.ObjectiveWe assessed associations of personal and clinical... περισσότερα »
Survival of patients with advanced metastatic melanoma: The impact of novel therapies
Publication date: January 2016 *Source:*European Journal of Cancer, Volume 53 Author(s): Selma Ugurel, Joachim Röhmel, Paolo A. Ascierto, Keith T. Flaherty, Jean Jacques Grob, Axel Hauschild, James Larkin, Georgina V. Long, Paul Lorigan, Grant A. McArthur, Antoni Ribas, Caroline Robert, Dirk Schadendorf, Claus Garbe The survival of advanced metastatic melanoma has been greatly improved within the past few years. New therapeutic strategies like kinase inhibitors for BRAF-mutant melanoma and immune checkpoint blockers proved to prolong survival times within clinical trials, and many o... περισσότερα »
Association of TIMP3 expression with vessel density, macrophage infiltration and prognosis in human malignant melanoma
Publication date: January 2016 *Source:*European Journal of Cancer, Volume 53 Author(s): Asha M. Das, Senada Koljenović, Charlotte M.C. Oude Ophuis, Thom van der Klok, Boris Galjart, Alex L. Nigg, Wiggert A. van Cappellen, Vincent Noordhoek Hegt, Winand N.M. Dinjens, Peggy N. Atmodimedjo, Cindy E. Vermeulen, Cornelis Verhoef, Alexander M.M. Eggermont, Timo L.M. ten Hagen AimsSeveral anti-tumour properties have been ascribed to the tissue inhibitor of matrix metalloproteinases-3 (TIMP3) gene, including inhibition of neovascularisation in tumour xenografts. Reduced protein expression h... περισσότερα »
Local molecular analysis of indeterminate thyroid nodules
Local molecular analysis of indeterminate thyroid nodules Abstract Background Thyroid nodules are common but only a minority are malignant. Molecular testing can assist in helping determine whether indeterminate nodules are suspicious for malignancy or benign. The objective of the study was to determine if the analysis of mutations (BRAF, NRAS, KRAS and HRAS) using readily available molecular techniques can help better classify indeterminate thyroid nodules. Methods A retrospective cohort of consecutive patients undergoing diagnostic thyroid surgery were analyzed for the pre... περισσότερα »
Adjuvant Radioactive iodine 133 ablation in papillary microcarcinoma of thyroid
“Adjuvant Radioactive iodine 133 ablation in papillary microcarcinoma of thyroid: Saudi Arabian experience Abstract Background Papillary Microcarcinoma (PMC) of thyroid is a rare type of differentiated thyroid cancer (DTC), which according to the World Health Organization measures 1.0 cm or less. The gold standard of treatment of PMC is still controversy. Our aim was to contribute in resolving the debate on the therapeutic choices of the surgical and adjuvant I-131 (RAI) treatment in PMC. Methods From 2000 to 2012, 326 patients were found to have PMC and were retrospective... περισσότερα »
Incidence of cutaneous malignant melanoma by socioeconomic status
Incidence of cutaneous malignant melanoma by socioeconomic status in Canada: 1992–2006 Abstract Background There are no nationwide studies documenting changes in cutaneous malignant melanoma incidence or association of incidence with socioeconomic status (SES) in Canada. We sought to determine whether melanoma incidence increased from 1992 to 2006 and if there was an association between SES and melanoma incidence. Additionally, we studied whether there was a correlation between province of residence and melanoma incidence. Methods Cases from the Canadian Cancer Registry we... περισσότερα »
Postnatal Neuroplasticity of Olfaction
A Critical Period in Postnatal Neuroplasticity of Olfaction: This pilot study examines olfactory deficits from early chronic tracheostomy following decannulation and explores whether there is a critical period in the postnatal development and neuroplasticity of olfaction. *Importance* There is controversy over whether a critical period in the development of olfaction exists, as there is in hearing and vision, whereby early stimulation of the olfactory nerve is necessary for normal olfactory performance later in life. Children who undergo tracheotomy early in life are deprived of... περισσότερα »
Dopamine Modulates the Activity of Sensory Hair Cells.
Dopamine Modulates the Activity of Sensory Hair Cells. J Neurosci. 2015 Dec 16;35(50):16494-16503 Authors: Toro C, Trapani JG, Pacentine I, Maeda R, Sheets L, Mo W, Nicolson T Abstract The senses of hearing and balance are subject to modulation by efferent signaling, including the release of dopamine (DA). How DA influences the activity of the …
Cryptococcal eosinophilic meningitis in a patient with sarcoidosis
A 51-year-old African-American man with underlying pulmonary, hepatic and splenic sarcoidosis, reported a 3-day history of headache, neck stiffness and photophobia. He was not using medication for chronic sarcoidosis. Physical examination was significant for nuchal rigidity. Lumbar puncture revealed marked eosinophilia in the cerebrospinal fluid, which, on further analysis, demonstrated a positive cryptococcal antigen. HIV …
Vitamin D3 enhances bactericidal activity of macrophage against Pseudomonas aeruginosa.
CONCLUSIONS: We show in this study that bioactive from of vitamin D [1,25-dihydroxyvitamin D3 (1,25D3)] can enhance M1 macrophage polarization and their bactericidal protective activity against P. aeruginosa. Future works would involve improving the treatment response through dose-dependent effect studies, both in ex vivo and in vivo models. PMID: 26655879 [PubMed – as supplied by …
MDM2 promotes rheumatoid arthritis via activation of MAPK and NF-κB.
In conclusion, MDM2 inhibition exhibits anti-inflammatory activity and MDM2 might be a new therapeutic target for RA. PMID: 26655743 [PubMed – as supplied by publisher] (Source: International Immunopharmacology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22dhKYR via IFTTT
Difficult diagnosis: internal herniation of the terminal ileum through the foramen of Winslow into the lesser sac
Herniation of the bowel through the foramen of Winslow is rare and accounts for 8% of all internal herniae. It typically presents clinically and biochemically as small bowel obstruction. It carries a high mortality as diagnosis is often delayed, despite bowel strangulation, as clinical signs are not typical and imaging may not be diagnostic. In …
A young man with extensor eruptive skin lesions
Description An obese 35-year-old man with a history of heavy alcohol consumption presented with non-pruritic papular skin eruptions of 3 months duration (figure 1). He was recently diagnosed to have type 2 diabetes, which was not well controlled (glycated haemoglobin, HbA1c 10.5%). Systemic examination was normal except for hepatomegaly. Serum biochemistry showed severe hypertriglyceridaemia (1550 …
Abdominal varicosities secondary to inferior vena cava filter thrombosis
Description A 43-year-old man with a medical history of multiple deep vein thrombosis and right inferior vena cava (IVC) filter placement, was evaluated for shortness of breath and venous claudication. Vital signs showed an O2 saturation of 90% on room air and a respiratory rate of 24 breaths/min. Physical examination revealed grossly dilated veins of …
Ziv-aflibercept: a novel option for the treatment of polypoidal choroidal vasculopathy
Polypoidal choroidal vasculopathy (PCV) is an exudative maculopathy usually treated using photodynamic therapy (PDT) and antivascular endothelial growth factor agents. However, these cases may sometimes be refractory to both PDT and ranibizumab or bevacizumab, and may have persistent intra-retinal fluid. Recently, studies have reported that aflibercept may be effective in such resistant cases. However, high …
Protective effect of EC-18, a synthetic monoacetyldiglyceride on lung inflammation in a murine model induced by cigarette smoke and lipopolysaccharide.
In conclusion, this study suggests that EC-18 has therapeutic potential for the treatment of chronic obstructive pulmonary disease. PMID: 26655742 [PubMed – as supplied by publisher] (Source: International Immunopharmacology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Ml0i8W via IFTTT
Closing faucets: the role of anti-angiogenic therapies in malignant pleural diseases
Abstract Malignant pleural effusion (MPE) represents 15–35 % of pleural effusions and markedly worsens the prognosis and quality of life of patients with cancer. Malignant mesothelioma (MM) and lung adenocarcinoma are the most frequent primary and secondary causes, respectively, of MPE. Effective treatments for cancer-related MPE are warranted in order to improve symptoms, reduce the …
Repetitive Transcranial Magnetic Stimulation and Tinnitus
Repetitive Transcranial Magnetic Stimulation and Tinnitus: *To the Editor* Regarding the recently published, randomized clinical trial by Folmer et al, using 1-Hz repetitive transcranial magnetic stimulation (rTMS) applied to the temporal cortex in patients with tinnitus for 10 days compared with placebo, the authors reported a significant reduction in tinnitus symptoms, the primary outcome measure. However, rTMS for tinnitus is still not significantly beneficial, so we have some considerations to share: [image: First page PDF preview]
Changing Patterns in Inpatient Pediatric Adenotonsillectomy
Changing Patterns in Inpatient Pediatric Adenotonsillectomy: This study of Nationwide Inpatient Sample data determines whether regionalization of inpatient pediatric adenotonsillectomies has occurred with respect to teaching hospital status and the proportion of patients using Medicaid as the primary payer. *Importance* Pediatric adenotonsillectomy is one of the most frequently performed procedures in the United States. Whereas several studies have focused on tonsillectomy techniques and outcomes, little is known about the overall changes in the distribution of care. Variations ... περισσότερα »
Reirradiation With MK-3475 (Pembrolizumab) in Locoregional Inoperable Recurrence or Second Primary Squamous Cell CA of the Head and Neck
Reirradiation With MK-3475 (Pembrolizumab) in Locoregional Inoperable Recurrence or Second Primary Squamous Cell CA of the Head and Neck: *Conditions*: Recurrent Head and Neck Cancer; Carcinoma, Squamous Cell of Head and Neck *Interventions*: Radiation: Reirradiation; Drug: MK-3475 *Sponsors*: Dan Zandberg; Merck Sharp & Dohme Corp. ArmsAssigned InterventionsExperimental: Reirradiation + MK-3475 Reirradiation 1.2 Gy BID for 5 days a week for 5 weeks with MK-3475 (Keytruda, pembrolizumab) 200mg intravenous every 3 weeks until 3 months post completion of reirradiation. R... περισσότερα »
Concurrent Chemotherapy for the Intermediate Risk Nasopharyngeal Carcinoma In Intensity-modulated Radiotherapy Era
Concurrent Chemotherapy for the Intermediate Risk Nasopharyngeal Carcinoma In Intensity-modulated Radiotherapy Era: *Condition*: Nasopharyngeal Carcinoma *Interventions*: Radiation: IMRT; Drug: Cisplatin *Sponsors*: Sun Yat-sen University; Guilin Medical University, China Currently, concurrent chemoradiotherapy with/without sequential chemotherapy is the standard treatment modality for intermediate risk NPC (stage II and T3N0M0) according to the National Comprehensive Cancer Network guideline. However these recommendations were based on the evidence in the two-dimension... περισσότερα »
SLC1A5 in the Development of Esophageal Cancer
Research on the Role of SLC1A5 in the Development of Esophageal Cancer: *Conditions*: Esophageal Cancer; Amino Acid Transport Disorder *Intervention*: Other: SLC1A5 expression *Sponsors*: Fourth Affiliated Hospital of Guangxi Medical University; Liuzhou Maternity and Child Healthcare Hospital Groups/CohortsAssigned Interventionscancer tissues SLC1A5 expression of esophageal cancer tissues from patients Other: SLC1A5 expression To observe the expression of SLC1A5 by immunohistochemistry and WesternBlot analysis. paired adjacent tissues SLC1A5 expression of paired adjacent e...περισσότερα »
Cisplatin Plus Docetaxel Versus Cetuximab, Cisplatin, and Docetaxel in Metastatic Nasopharyngeal Carcinoma
Cisplatin Plus Docetaxel Versus Cetuximab, Cisplatin, and Docetaxel in Metastatic Nasopharyngeal Carcinoma: *Condition*: Nasopharyngeal Carcinoma *Interventions*: Drug: Cetuximab; Drug: Cisplatin; Drug: Docetaxel; Drug: Capecitabine; Radiation: Radiotherapy *Sponsors*: Sun Yat-sen University; Chinese Southwest Oncology Group ArmsAssigned InterventionsActive Comparator: cisplatin and docetaxel Induction chemotherapy: Patients receive cisplatin and docetaxel intravenously on day 1 repeated every 3 weeks for 6 cycles. Concurrent chemoradiation: Patients who achieve comp... περισσότερα »
Investigation of Contralateral Arytenoid Sparing IMRT for T1a & T2a Larynx Cancer & Analysis of Post-treatment Laryngeal Function
Investigation of Contralateral Arytenoid Sparing IMRT for T1a & T2a Larynx Cancer & Analysis of Post-treatment Laryngeal Function: *Condition*: Laryngeal Neoplasms *Intervention*: Radiation: IMRT Radiation *Sponsor*: Fox Chase Cancer Center ArmsAssigned InterventionsExperimental: IMRT Radiation All subjects will be treated using IMRT with the standard fractionation for T1a glottic cancer at Fox Chase Cancer Center: 63 Gy in 28 fractions; 6 for T1a and 65.25 Gy in 29 fractions; 33 for T2a. Treatment will be followed by functional assessments performed at months 1,3,6,12,and 2...περισσότερα »
Patritumab or Placebo in Combination With Cetuximab and a Platinum Agent for Patients With Squamous Cell Cancer of the Head and Neck
A Clinical Trial Using Patritumab or Placebo in Combination With Cetuximab and a Platinum Agent for Patients With Squamous Cell Cancer of the Head and Neck: *Conditions*: Neoplasms by Site; Head and Neck Neoplasms; Squamous Cell Cancer of the Head and Neck *Interventions*: Drug: patritumab; Drug: Cetuximab; Drug: Cisplatin or carboplatin; Drug: placebo *Sponsors*: Daiichi Sankyo Inc.; Covance ArmsAssigned InterventionsExperimental: Patritumab/cetuximab/cisplatin or carboplatin Patritumab initial loading dose is 18 mg/kg IV over 60 minutes followed bya maintenanc... περισσότερα »
Thyroid Nodule Size, Bethesda Class, and Rate of Malignant Disease
Thyroid Nodule Size, Bethesda Class, and Rate of Malignant Disease: This medical record review demonstrates that large thyroid nodules (TNs) of any given Bethesda class are not associated with increased probability of malignant disease beyond that which is expected based on their cytological classification and suggest that smaller TNs pose a relatively increased risk of malignant disease. *Importance* The ability to accurately stratify patients with thyroid nodules (TNs) preoperatively is imperative because most TNs are benign. The reliability of fine-needle aspiration biopsy (... περισσότερα »
Gene Expression Classifier Testing for Patients With Thyroid Nodules
Gene Expression Classifier Testing for Patients With Thyroid Nodules: This study examines surgical decisions made for patients with indeterminate thyroid nodules who underwent gene expression classifier (GEC) testing and compares actual vs recommended treatments to determine the effects on management of GEC testing. *Importance* Commercial molecular testing, such as the gene expression classifier (GEC), is now being used in the work up of cytologically indeterminate thyroid nodules. While this test may be helpful in ruling out malignancy in a thyroid nodule, its effect on surgic...περισσότερα »
Fibroblast-Facilitated Head and Neck Cancer and Ficlatuzumab
Fibroblast-Facilitated Head and Neck Cancer and Ficlatuzumab: This Original Investigation demonstrates that neutralizing tumor-associated fibroblast–derived hepatocyte growth factor with ficlatuzumab effectively mitigates c-Met signaling and decreases HNSCC proliferation, migration, and invasion. *Importance* Ficlatuzumab can be used to treat head and neck squamous cell carcinoma (HNSCC) by inhibiting c-Met receptor-mediated cell proliferation, migration, and invasion. *Objective* To understand the effect of ficlatuzumab on HNSCC proliferation, migration, and invasion. *Design, Se...περισσότερα »
Sleep Studies in Children Who Snore
The Role of Sleep Studies in Children Who Snore: This clinical review examines sleep studies, the only validated method of diagnosing obstructive sleep apnea, and determines if they are essential for children with tonsillar hypertrophy who snore and have symptoms of sleep-disordered breathing. *Hypothesis* Sleep studies (ie, polysomnography) should be used in children who snore and exhibit symptoms of sleep-disordered breathing (SDB) to determine the presence and severity of obstructive sleep apnea (OSA).
A clinical study of the outcomes and complications associated with zygomatic buttress block bone graft for limited preimplant augmentation procedures
Publication date: Available online 17 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Andreas Sakkas, Alexander Schramm, Winter Karsten, Nils-Claudius Gellrich, Frank Wilde PurposeThe aim of this study was to evaluate the possibility of using the zygomatic buttress as an intraoral bone harvesting donor site and determine the safety of this harvesting procedure for later optimal positioning of dental implants in accordance with prosthodontic and functional principles.Material and MethodsA consecutive retrospective study was conducted on patients who had been... περισσότερα »
Change in mandibular body height at the site of a fixation plate in the advance (lengthening) and setback (shortening) sides after sagittal split ramus osteotomy
Publication date: Available online 17 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Koichiro Ueki, Kunio Yoshizawa, Akinori Moroi, Ran Iguchi, Akihiko Kosaka, Hiroumi Ikawa, Takamitsu Tsutsui, Yuriko Saida, Asami Hotta PurposeThe purpose of this study was to evaluate changes in mandibular body height at the site of a fixation plate in the advance (lengthening) and setback (shortening) sides after sagittal split ramus osteotomy (SSRO).Subjectsand Methods: The subjects were 49 patients (98 sides) who underwent bilateral SSRO surgery. The subjects were divide...περισσότερα »
Comparison of tooth-borne and hybrid devices in surgically assisted rapid maxillary expansion: a randomized clinical cone-beam computed tomography study
Publication date: Available online 17 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Emre Kayalar, Michael Schauseil, Samet Vasfi Kuvat, Ufuk Emekli, Sonmez Firatli purposeThe objective of this 2-arm, parallel, single-center trial was to compare the skeletal, dental, and periodontal effects of tooth-borne (TB) and hybrid devices in surgically assisted rapid maxillary expansion (SARME).materials and methodsTwenty consecutive patients (9 male and 11 female) with skeletal transverse maxillary deficiency seeking treatment at the Department of Orthodontics at I...περισσότερα »
„Narrow band imaging“ zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg
„Narrow band imaging“ zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg: ZusammenfassungDie verschiedenen Stadien des Tumorwachstums sind durch typische epitheliale, vaskuläre und sekundäre bindegewebige Veränderungen charakterisiert. Die Endoskopie mittels „narrow band imaging“ (NBI) stellt ein minimalinvasives bildgebendes Verfahren dar, das insbesondere vaskuläre Strukturen kontrastreicher darstellt als die Weißlichtendoskopie allein. In Kombination mit hochauflösenden Aufnahme- und Wiedergabeverfahren („high-definition television“,... περισσότερα »
Headaches of otolaryngological origin
Headaches of otolaryngological origin via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 18 December 2015 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D.T. Ginat, S.-K. Lee, F. Baroody [image: a and b: axial post-contrast sinus CT images in the soft tissue (a) and bone (b) ...]
Biostable electrospun microfibrous scaffolds mitigate hypertrophic scar contraction
in an immune-competent murine model via Acta Biomaterialia Publication date: Available online 17 December 2015 *Source:*Acta Biomaterialia Author(s): Elizabeth R. Lorden, Kyle J. Miller, Mohamed M. Ibrahim, Latif Bashirov, Ellen Hammett, Syandan Chakraborty, Carlos Quiles-Torres, M. Angelica Selim, Kam W. Leong, Howard Levinson Burn injuries in the United States account for over one million hospital admissions per year, with treatment estimated at four billion dollars. Of severe burn patients, 30-90% will develop hypertrophic scars (HSc). In this study, we evaluate the impact of an el... περισσότερα »
Platelet Lysate-based Pro-Angiogenic Nanocoatings
Platelet Lysate-based Pro-Angiogenic Nanocoatings via Acta Biomaterialia Publication date: Available online 17 December 2015 *Source:*Acta Biomaterialia Author(s): Sara M. Oliveira, Rogério P. Pirraco, Alexandra P. Marques, Vítor E. Santo, Manuela E. Gomes, Rui L. Reis, João F. Mano Human platelet lysate (PL) is a cost-effective and human source of autologous multiple and potent pro-angiogenic factors, such as vascular endothelial growth factor A (VEGF A), fibroblast growth factor b (FGF b) and angiopoietin-1. Nanocoatings previously characterized were prepared by layer-by-layer assemb... περισσότερα »
Perception of stochastic envelopes
by normal-hearing and cochlear-implant listeners via Hearing Research Publication date: Available online 17 December 2015 *Source:*Hearing Research Author(s): Philip A. Gomersall, Richard E. Turner, David M. Baguley, John M. Deeks, Hedwig E. Gockel, Robert P. Carlyon We assessed auditory sensitivity to three classes of temporal-envelope statistics (modulation depth, modulation rate, and comodulation) that are important for the perception of ‘sound textures’. The textures were generated by a probabilistic model that prescribes the temporal statistics of a selected number of modulation ...περισσότερα »
Promoting High Value, Patient-Centric Care with Alternative and Complementary Devices
Promoting High Value, Patient-Centric Care with Alternative and Complementary Devices: Today, I want to talk about some industry challenges and opportunities that are in front us as they relate to changes in the marketplace with the aging population and the influx of baby boomers. We will talk about some alternative and complementary devices, one of which is Hypersound, and why and how that might be a viable treatment option for patients.
Low-frequency sound exposure causes reversible long-term changes of cochlear transfer characteristics
Low-frequency sound exposure causes reversible long-term changes of cochlear transfer characteristics via Hearing Research Publication date: Available online 17 December 2015 *Source:*Hearing Research Author(s): Markus Drexl, Larissa Otto, Lutz Wiegrebe, Torsten Marquardt, Robert Gürkov, Eike Krause Intense, low-frequency sound presented to the mammalian cochlea induces temporary changes of cochlear sensitivity, for which the term ‘Bounce’ phenomenon has been coined. Typical manifestations are slow oscillations of hearing thresholds or the level of otoacoustic emissions. It has been s... περισσότερα »
Hemispheric lateralization in auditory imagery
Hearing it right: Evidence of via Hearing Research Publication date: Available online 17 December 2015 *Source:*Hearing Research Author(s): Giulia Prete, Daniele Marzoli, Alfredo Brancucci, Luca Tommasi An advantage of the right ear (REA) in auditory processing (especially for verbal content) has been firmly established in decades of behavioral, electrophysiological and neuroimaging research. The laterality of auditory imagery, however, has received little attention, despite its potential relevance for the understanding of auditory hallucinations and related phenomena. In Experiments ... περισσότερα »
[Muenster Parental Programme - Feedback from Parents : How do parents evaluate an early intervention programme for improving the communication with their baby or toddler with hearing impairment?]
*[Muenster Parental Programme - Feedback from Parents : How do parents evaluate an early intervention programme for improving the communication with their baby or toddler with hearing impairment?]* HNO. 2015 Dec 16; Authors: Glanemann R, Reichmuth K, Am Zehnhoff-Dinnesen A Abstract BACKGROUND: With the implementation of the UNHS, early educational services' existing concepts of early intervention have to be adapted to the situation and needs of families with a preverbal child who is deaf or hard of hearing. The Muenster Parental Programme (MPP), a module in early family-centered... περισσότερα »
Partial corrosion casting to assess cochlear vasculature in mouse models of presbycusis and CMV infection
Publication date: Available online 18 December 2015 *Source:*Hearing Research Author(s): Mattia Carraro, Albert H. Park, Robert V. Harrison Some forms of sensorineural hearing loss involve damage or degenerative changes to the stria vascularis and/or other vascular structures in the cochlea. In animal models, many methods for anatomical assessment of cochlear vasculature exist, each with advantages and limitations. One methodology, corrosion casting, has proved useful in some species, however in the mouse model this technique is difficult to achieve because digestion of non vascular... περισσότερα »
Large-scale phenotyping of noise-induced hearing loss
in 100 strains of mice via Hearing Research Publication date: Available online 17 December 2015 *Source:*Hearing Research Author(s): Anthony Myint, Cory H. White, Jeffrey D. Ohmen, Xin Li, Juemei Wang, Joel Lavinsky, Pezhman Salehi, Amanda L. Crow, Takahiro Ohyama, Rick A. Friedman A cornerstone technique in the study of hearing is the Auditory Brainstem Response (ABR), an electrophysiologic technique that can be used as a quantitative measure of hearing function. Previous studies have published databases of baseline ABR thresholds for mouse strains, providing a valuable resource for... περισσότερα »
Partial corrosion casting to assess cochlear vasculature
in mouse models of presbycusis and CMV infection via Hearing Research Publication date: Available online 18 December 2015 *Source:*Hearing Research Author(s): Mattia Carraro, Albert H. Park, Robert V. Harrison Some forms of sensorineural hearing loss involve damage or degenerative changes to the stria vascularis and/or other vascular structures in the cochlea. In animal models, many methods for anatomical assessment of cochlear vasculature exist, each with advantages and limitations. One methodology, corrosion casting, has proved useful in some species, however in the mouse model this...περισσότερα »
A young man with extensor eruptive skin lesions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Description An obese 35-year-old man with a history of heavy alcohol consumption presented with non-pruritic papular skin eruptions of 3 months duration (figure 1). He was recently diagnosed to have type 2 diabetes, which was not well controlled (glycated haemoglobin, HbA1c 10.5%). Systemic examination was normal except for hepatomegaly. Serum biochemistry showed severe hypertriglyceridaemia (1550 […]
Abdominal varicosities secondary to inferior vena cava filter thrombosis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Description A 43-year-old man with a medical history of multiple deep vein thrombosis and right inferior vena cava (IVC) filter placement, was evaluated for shortness of breath and venous claudication. Vital signs showed an O2 saturation of 90% on room air and a respiratory rate of 24 breaths/min. Physical examination revealed grossly dilated veins of […]
Long noncoding RNAs in lung cancer: what we know in 2015
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Lung cancer ranks as the first most common cancer and the first leading cause of cancer-related death in China and worldwide. Due to the difficulty in early diagnosis and the onset of cancer metastasis, the 5-year survival rate of lung cancer remains extremely low. Long noncoding RNAs (lncRNAs), which lacking protein-coding ability, have recently […]
Closing faucets: the role of anti-angiogenic therapies in malignant pleural diseases
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Malignant pleural effusion (MPE) represents 15–35 % of pleural effusions and markedly worsens the prognosis and quality of life of patients with cancer. Malignant mesothelioma (MM) and lung adenocarcinoma are the most frequent primary and secondary causes, respectively, of MPE. Effective treatments for cancer-related MPE are warranted in order to improve symptoms, reduce the […]
SEOM Guidelines 2015: a new era in the collaboration with the Spanish Cancer Research Cooperative Groups
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1mqzhfH via IFTTT
Dopamine Modulates the Activity of Sensory Hair Cells.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Dopamine Modulates the Activity of Sensory Hair Cells. J Neurosci. 2015 Dec 16;35(50):16494-16503 Authors: Toro C, Trapani JG, Pacentine I, Maeda R, Sheets L, Mo W, Nicolson T Abstract The senses of hearing and balance are subject to modulation by efferent signaling, including the release of dopamine (DA). How DA influences the activity of the […]
(Non-) invasive mapping of cortical language areas
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 17 December 2015 Source:Clinical Neurophysiology Author(s): Muthuraman Muthuraman, Gesa Hartwigsen, Sergiu Groppa from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1Rta7cS via IFTTT
Needle electromyography findings in patients with MATR3 mutation – a prospective study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 18 December 2015 Source:Clinical Neurophysiology Author(s): F. Hanisch, T. Kraya, T. Müller, M. Kornhuber from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1UIDB5o via IFTTT
Audiological Profile in Primary Sjögren’s Syndrome in a Tertiary Care Setting and its Clinical Implic ations
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract This study aims to assess the frequency and the profile of hearing loss among patients with primary Sjögren’s syndrome in a tertiary care hospital in India and to look for an association between hearing loss and immunological parameters (anti-SSA antibody, anti-SSB antibody, anticardiolipin antibodies, complements C3 and C4). This prospective observational study was done […]
Preventive Audiology: Screening for Hearing Impairment in Children Having Recurrent URTI
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract A late detection of hearing impairment in children can affect speech and language development. Otitis media with effusion (OME) associated with risk factors like recurrent upper respiratory tract infections (URTI) is considered the most common cause of silent hearing impairment among children. So this study was carried out to screen such at risk children […]
Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer Cell Research advance online publication, December 18 2015. doi:10.1038/cr.2015.150 Authors: Ke Chen, Jing Zhang, Zhongqiang Guo, Qin Ma, Zhengzheng Xu, Yuanyuan Zhou, Zhiying Xu, Zhongwu Li, Yiqiang Liu, Xiongjun Ye, Xuesong Li, Bifeng Yuan, Yuwen Ke, Chuan He, Liqun Zhou, Jiang Liu & […]
Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Birth of fertile bimaternal offspring following intracytoplasmic injection of parthenogenetic haploid embryonic stem cells Cell Research advance online publication, December 18 2015. doi:10.1038/cr.2015.151 Authors: Zhikun Li, Haifeng Wan, Guihai Feng, Leyun Wang, Zhengquan He, Yukai Wang, Xiu-Jie Wang, Wei Li, Qi Zhou & Baoyang Hu from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ObK4jU via IFTTT
MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder. Oral Oncol. 2015 Dec 7; Authors: Hung KF, Liu CJ, Chiu PC, Lin JS, Chang KW, Shih WY, Kao SY, Tu HF Abstract OBJECTIVES: MicroRNAs (miRNAs, miRs) have shown diagnostic and prognostic potential for oral cancer but their role in oral potentially malignant […]
Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Long-term patterns of relapse and survival following definitive intensity-modulated radiotherapy for non-endemic nasopharyngeal carcinoma. Oral Oncol. 2015 Dec 7; Authors: Setton J, Han J, Kannarunimit D, Wuu YR, Rosenberg SA, DeSelm C, Wolden SL, Jillian Tsai C, McBride SM, Riaz N, Lee NY Abstract BACKGROUND: We report treatment outcomes for a large non-endemic cohort of […]
The 10 most crucial things you can to do reduce your cancer risk – Netdoctor
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Netdoctor The 10 most crucial things you can to do reduce your cancer risk Netdoctor Alcohol is implicated in around 4% of the cases of cancer diagnosed within the UK every year, and is associated with cancer of the mouth and throat, oesphagus, larynx, breast, bowel and liver. When our bodies process alcohol, it’s converted […]
IJERPH, Vol. 12, Pages 16070-16081: A Survey of 42 Semi-Volatile Organic Contaminants in Groundwater along the Grand Canal from Hangzhou to Beijing, East China
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The status of organic pollution in groundwater in eastern China along the Grand Canal from Hangzhou to Beijing was evaluated. Forty-two semi-volatile organic contaminants were analyzed, including 16 polycyclic aromatic hydrocarbons (PAHs), seven polychlorinated biphenyls (PCBs), 12 organochlorine pesticides (OCPs) and seven organophosphorus pesticides (OPPs). Among the detected contaminants, PAHs were the most widespread compounds. […]
IJERPH, Vol. 12, Pages 16096-16109: Classifying Natural Waters with the Forel-Ule Colour Index System: Results, Applications, Correlations and Crowdsourcing
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Societal awareness of changes in the environment and climate has grown rapidly, and there is a need to engage citizens in gathering relevant scientific information to monitor environmental changes due to recognition that citizens are a potential source of critical information. The apparent colour of natural waters is one aspect of our aquatic environment that […]
IJERPH, Vol. 12, Pages 16082-16095: Anthropometric Status and Nutritional Intake in Children (6–9 Years) in Valencia (Spain): The ANIVA Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The aim of our study was to assess nutritional intake and anthropometric statuses in schoolchildren to subsequently determine nutritional adequacy with Spanish Dietary Reference Intake (DRIs). The ANIVA study, a descriptive cross-sectional study, was conducted in 710 schoolchildren (6–9 years) in 2013–2014 in Valencia (Spain). Children’s dietary intake was measured using 3-day food records, completed […]
IJERPH, Vol. 12, Pages 16060-16069: Associations between Dietary Factors and Self-Reported Physical Health in Chinese Scientific Workers
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Background: Scientific workers play an important role in the development of science and technology. However, evidence is lacking with regard to the associations between their dietary factors and their health-related quality of life (HRQOL). Methods: A cross-sectional survey was conducted among 775 scientific workers from multiple universities and institutes in the Southwest region of China. […]
IJERPH, Vol. 12, Pages 16110-16123: A Spatial Framework to Map Heat Health Risks at Multiple Scales
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In the last few decades extreme heat events have led to substantial excess mortality, most dramatically in Central Europe in 2003, in Russia in 2010, and even in typically cool locations such as Vancouver, Canada, in 2009. Heat-related morbidity and mortality is expected to increase over the coming centuries as the result of climate-driven global […]
Neonatal Transcutaneous Carbon Dioxide Monitoring—Effect on Clinical Management and Outcomes
BACKGROUND:This work aimed to compare frequency of blood gas measurements per day of mechanical ventilation, occurrence of extreme blood gas CO2 values, and clinical outcomes among ventilated neonates managed with and without transcutaneous carbon dioxide (PtcCO2) monitors. This work also measures agreement between simultaneous PtcCO2 and blood gas CO2 measurements and ascertains factors that affect agreement.METHODS:This is a cohort study with retrospective analysis comparing 5,726 blood gas measurements and clinical outcomes for 123 neonates intubated for >48 h before and after ... περισσότερα »
The Role of Mean Platelet Volume in Chronic Obstructive Pulmonary Disease Exacerbation
BACKGROUND:Studies have supported the correlation between mean platelet volume and COPD. However, there are limited data on the relationship between COPD exacerbation and mean platelet volume. We aimed to evaluate the mean platelet volume trend in patients with COPD exacerbation.METHODS:A total of 81 subjects, 62 men and 19 women, who were admitted to the hospital because of exacerbation of COPD during 9 months, were enrolled in this prospective observational study. The levels of mean platelet volume, C-reactive protein, complete blood count, and percent-of-predicted FEV1 were mea... περισσότερα »
Asthma Control Assessment Tools
Both the National Asthma Education and Prevention Program Expert Panel Report 3 and the 2015 Global Initiative for Asthma guidelines identify achieving and maintaining asthma control as goals of therapy, and they emphasize periodic assessment of asthma control once treatment is established. Accurate assessment of asthma control is difficult due to the complexity of asthma control and due to the limitations in the traditional methods of assessment, such as lung function tests, physician assessment, and patients' self-assessment. Relying solely on the role of lung function tests is ...περισσότερα »
Inhibition of CXCR4 and CXCR7 for reduction of cell proliferation and invasion in human endometrial cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract As one of the most common malignant cancers in female reproductive tract, endometrial cancer accounts for 20–30 % of the most frequent gynecological malignancy, which is originated from endometrial epithelial. The molecular mechanisms for the generation of endometrial cancer are up to now unclear, hindering the development of corresponding therapy. CXCR4 and CXCR7 were […]
MicroRNA-9 promotes proliferation of leukemia cells in adult CD34-positive acute myeloid leukemia with normal karyotype by downregulation of Hes1
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Acute myeloid leukemia (AML) is a group of heterogeneous hematopoietic malignancies sustained by leukemic stem cells (LSCs) that can resist treatment. Previously, we found that low expression of Hes1 was a poor prognostic factor for AML. However, the activation status of Hes1 and its regulation in LSCs and leukemic progenitors (LPs) as well as […]
Overexpression of interleukins IL-17 and IL-8 with poor prognosis in colorectal cancer induces metastasis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Current evidences indicated that a group of soluble mediators called chemokines is involved in tumor growth and metastasis. The association of IL-8 with tumor cell migration was previously found, and its expression was related to angiogenesis, tumor progression, and metastasis in many kinds of carcinomas in human and animal models. Furthermore, it has been […]
Tumor-suppressive microRNA-34a inhibits breast cancer cell migration and invasion via targeting oncogenic TPD52
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The tumor protein D52 (TPD52) is an oncogene overexpressed in breast cancer. Although the oncogenic effects of TPD52 are well recognized, how its expression and the role in migration/invasion is still not clear. This study tried to explore the regulative role of microRNA-34a (miR-34a), a tumor suppressive miRNA, on TPD52 expression in breast cancer. […]
Lessons from other diseases: granulomatous inflammation in leishmaniasis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract The Leishmania granuloma shares some, though not all, properties with that formed following mycobacterial infection. As a simplified, noncaseating granuloma composed of relatively few and largely mononuclear cell populations, it provides a tractable model system to investigate intra-granuloma cellular dynamics, immune regulation, and antimicrobial resistance. Here, the occurrence of granulomatous pathology across the spectrum […]
New options in adjuvant endocrine therapy in breast cancer.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
[New options in adjuvant endocrine therapy in breast cancer]. Bull Cancer. 2015 Dec 7; Authors: Saltel-Fulero A, Donnadieu A, Leman-Detours S, Cottu P Abstract Endocrine therapy is a compulsory step in the adjuvant management of early breast cancer expressing the estrogen receptor, by reducing as much as possible serum and tissue levels of estrogens. Tamoxifen […]
Cancers, Vol. 7, Pages 2466-2485: Oncogenic MicroRNAs: Key Players in Malignant Transformation
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or […]
Hearing it right: Evidence of hemispheric lateralization in auditory imagery
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 17 December 2015 Source:Hearing Research Author(s): Giulia Prete, Daniele Marzoli, Alfredo Brancucci, Luca Tommasi An advantage of the right ear (REA) in auditory processing (especially for verbal content) has been firmly established in decades of behavioral, electrophysiological and neuroimaging research. The laterality of auditory imagery, however, has received little attention, despite […]
Low-frequency sound exposure causes reversible long-term changes of cochlear transfer characteristics
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 17 December 2015 Source:Hearing Research Author(s): Markus Drexl, Larissa Otto, Lutz Wiegrebe, Torsten Marquardt, Robert Gürkov, Eike Krause Intense, low-frequency sound presented to the mammalian cochlea induces temporary changes of cochlear sensitivity, for which the term ‘Bounce’ phenomenon has been coined. Typical manifestations are slow oscillations of hearing thresholds or the […]
Perception of stochastic envelopes by normal-hearing and cochlear-implant listeners
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Publication date: Available online 17 December 2015 Source:Hearing Research Author(s): Philip A. Gomersall, Richard E. Turner, David M. Baguley, John M. Deeks, Hedwig E. Gockel, Robert P. Carlyon We assessed auditory sensitivity to three classes of temporal-envelope statistics (modulation depth, modulation rate, and comodulation) that are important for the perception of ‘sound textures’. The textures […]
Cryptococcal eosinophilic meningitis in a patient with sarcoidosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A 51-year-old African-American man with underlying pulmonary, hepatic and splenic sarcoidosis, reported a 3-day history of headache, neck stiffness and photophobia. He was not using medication for chronic sarcoidosis. Physical examination was significant for nuchal rigidity. Lumbar puncture revealed marked eosinophilia in the cerebrospinal fluid, which, on further analysis, demonstrated a positive cryptococcal antigen. HIV […]
Difficult diagnosis: internal herniation of the terminal ileum through the foramen of Winslow into the lesser sac
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Herniation of the bowel through the foramen of Winslow is rare and accounts for 8% of all internal herniae. It typically presents clinically and biochemically as small bowel obstruction. It carries a high mortality as diagnosis is often delayed, despite bowel strangulation, as clinical signs are not typical and imaging may not be diagnostic. In […]
Ziv-aflibercept: a novel option for the treatment of polypoidal choroidal vasculopathy
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Polypoidal choroidal vasculopathy (PCV) is an exudative maculopathy usually treated using photodynamic therapy (PDT) and antivascular endothelial growth factor agents. However, these cases may sometimes be refractory to both PDT and ranibizumab or bevacizumab, and may have persistent intra-retinal fluid. Recently, studies have reported that aflibercept may be effective in such resistant cases. However, high […]
A young man with extensor eruptive skin lesions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Description An obese 35-year-old man with a history of heavy alcohol consumption presented with non-pruritic papular skin eruptions of 3 months duration (figure 1). He was recently diagnosed to have type 2 diabetes, which was not well controlled (glycated haemoglobin, HbA1c 10.5%). Systemic examination was normal except for hepatomegaly. Serum biochemistry showed severe hypertriglyceridaemia (1550 […]
Abdominal varicosities secondary to inferior vena cava filter thrombosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Description A 43-year-old man with a medical history of multiple deep vein thrombosis and right inferior vena cava (IVC) filter placement, was evaluated for shortness of breath and venous claudication. Vital signs showed an O2 saturation of 90% on room air and a respiratory rate of 24 breaths/min. Physical examination revealed grossly dilated veins of […]
Angioleiomyoma of the larynx: beware the subglottic lesion
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Angioleiomyomas are a benign group of tumours rarely documented in the head and neck region. We present a case of a 47-year-old man attending the ear, nose and throat outpatient clinic, with a history of hoarseness over many years. Investigation revealed a left-sided subglottic lesion. He underwent microlaryngoscopy and biopsy, and the lesion was sent […]
Unusual pattern of neonatal hyperhidrosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Description A 10-day-old Caucasian boy presented at the emergency department with a history of excessive sweating in the last 3 days, especially during feedings (figure 1). Figure 1 Unilateral hyperhidrosis, requiring multiple changes of clothes. The red line illustrates the body’s midline. On presentation, the patient was systemically well without fever or irritability. A distinct […]
Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses.
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses. J Laryngol Otol. 2015 Dec 17;:1-7 Authors: Keilmann A, Bendel F, Nospes S, Lampe C, Läßig AK Abstract OBJECTIVE: This study aimed to: assess the mucosal alterations of the larynx and hypopharynx typical for mucopolysaccharidoses, in a standardised manner; compare the severity in […]
Metformin für Typ-1-Diabetiker?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Unklare Vorteile Eine Zusatztherapie mit Metformin führt bei übergewichtigen Jugendlichen mit Typ-1-Diabetes nicht zu einer besseren Blutzuckerkontrolle. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UICJh0 via IFTTT
Alkoholsucht therapieren – Darmkrebsrate senken
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Gastroenterologen rufen zum Handeln auf Alkohol gilt ja als einer der wichtigsten Risikofaktoren für Darmkrebs: Etwa jede 10. Erkrankung steht im Zusammenhang mit dem Konsum von Bier, Wein, Schnaps und anderen Spirituosen, erinnert die Deutsche Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/22dcaWr via IFTTT
Angiostrongylus cantonensis cathepsin B-like protease (Ac-cathB-1) is involved in host gut penetration
Authors: Ying Long, Binbin Cao, Liang Yu, Meks Tukayo, Chonglv Feng, Yinan Wang and Damin Luo.<br>Parasite Vol. 22 , page 37<br>Published online: 18/12/2015<br> Keywords: Lentiviral expression ; Angiostrongylus cantonensis ; Recombinant Ac-cathB-1 ; Protease.<img src="http://ift.tt/1Rt84FQ" height="1" width="1" alt=""> from #Medicine via ola Kala on Inoreader http://ift.tt/1UIz0jL via IFTTT
Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism
Abstract Channel block and permeation by cytoplasmic polyamines is a common feature of many cation-selective ion-channels. Although the channel block mechanism has been studied extensively, polyamine permeation has been considered less significant as it occurs at extreme positive membrane potentials. Here, we show that kainate receptor (KAR) heteromerization and association with auxiliary proteins, Neto1 and Neto2, attenuate polyamine block by enhancing blocker permeation. Consequently, polyamine permeation and unblock occur at more negative and physiologically-relevant membrane po... περισσότερα »
IJMS, Vol. 16, Pages 30204-30222: MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma
MicroRNAs represent ~22 nt long endogenous small RNA molecules that have been experimentally shown to regulate gene expression post-transcriptionally. One main interest in miRNA research is the investigation of their functional roles, which can typically be accomplished by identification of mi-/mRNA interactions and functional annotation of target gene sets. We here present a novel method "miRlastic", which infers miRNA-target interactions using transcriptomic data as well as prior knowledge and performs functional annotation of target genes by exploiting the local structure of th... περισσότερα »
IJMS, Vol. 16, Pages 30190-30203: Comparative Transcriptome Analysis of Genes Involved in GA-GID1-DELLA Regulatory Module in Symbiotic and Asymbiotic Seed Germination of Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae)
Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae) is an endangered medicinal plant in China, also called "King Medicine". Due to lacking of sufficient nutrients in dust-like seeds, orchid species depend on mycorrhizal fungi for seed germination in the wild. As part of a conservation plan for the species, research on seed germination is necessary. However, the molecular mechanism of seed germination and underlying orchid-fungus interactions during symbiotic germination are poorly understood. In this study, Illumina HiSeq 4000 transcriptome sequencing was performed to generate a... περισσότερα »
IJMS, Vol. 16, Pages 30181-30189: Randomized Controlled Trial of Darbepoetin α Versus Continuous Erythropoietin Receptor Activator Injected Subcutaneously Once Every Four Weeks in Patients with Chronic Kidney Disease at the Pre-Dialysis Stage
Continuous erythropoietin receptor activator (CERA) seems to maintain a stable hemoglobin (Hb) level because its half-life is longer than darbepoetin α (DA). Twenty chronic kidney disease (CKD) patients at the pre-dialysis stage who had been administered DA for over 24 weeks were randomly assigned to receive subcutaneous CERA or DA once every four weeks during 48 weeks. In both groups, the rate of achievement of target Hb level changed from 70% to 100% in weeks 0 to 48, with no significant difference between the groups. Compared with week 0, the Hb level was significantly increase...περισσότερα »
Effectiveness of Using Cellular Phones to Transmit Real-Time Shelter Morbidity Surveillance Data After Hurricane Sandy, New Jersey, October to November, 2012
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Research Articles Alice M. Shumate, Ellen E. Yard, Mary Casey-Lockyer, Andria Apostolou, Miranda Chan, Christina Tan, Rebecca S. Noe, Amy F. Wolkin Disaster Medicine and Public Health Preparedness, FirstView Article(s), 4 pages Abstract from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/22d7hfQ via IFTTT
Clinical Response, Outbreak Investigation, and Epidemiology of the Fungal Meningitis Epidemic in the United States: Systematic Review
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Review Articles Kaja M. Abbas, Nargesalsadat Dorratoltaj, Margaret L. O’Dell, Paige Bordwine, Thomas M. Kerkering, Kerry J. Redican Disaster Medicine and Public Health Preparedness, FirstView Article(s), 7 pages Abstract from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Nt7Iv3 via IFTTT
Multivariable analysis to determine if HIV-1 Tat dicysteine motif is associated with neurodevelopmental delay in HIV-infected children in Malawi
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
HIV-1 Tat protein is implicated in HIV-neuropathogenesis. Tat C31S polymorphism (TatCS) has been associated with milder neuropathology in vitro and in animal models but this has not been addressed in a cohort of … from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qu34AR via IFTTT
The John Bannon I knew – The Advertiser
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
The Advertiser The John Bannon I knew The Advertiser Unrequested, JC Bannon had become Winston Churchill during the War. Not an imitation, not mimicry, this was Churchill. Vast passages of War speeches rolled from his tongue, the nuance of Churchill, the grand sweep of phrase leading unto a crescendo at … from #AlexandrosSfakianakis via Alexandros […]
Giant basal cell carcinoma of the face: surgical management and challenges for reconstruction.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Giant basal cell carcinoma of the face: surgical management and challenges for reconstruction. J Laryngol Otol. 2015 Dec 17;:1-7 Authors: Maimaiti A, Mijiti A, Yarbag A, Moming A Abstract BACKGROUND: Giant basal cell carcinoma, in which the tumour measures 5 cm or greater in diameter, is a very rare skin malignancy that accounts for less […]
Healthcare provider contact for children with symptoms of sleep-disordered breathing: a population survey.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Healthcare provider contact for children with symptoms of sleep-disordered breathing: a population survey. J Laryngol Otol. 2015 Dec 17;:1-6 Authors: Gudnadottir G, Ehnhage A, Bende M, Andersson M, Cervin A, Cardell LO, Hellgren J Abstract BACKGROUND: Symptoms of sleep-disordered breathing in children, such as frequent snoring, apnoea and choking, may lead to health problems if […]
Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses. J Laryngol Otol. 2015 Dec 17;:1-7 Authors: Keilmann A, Bendel F, Nospes S, Lampe C, Läßig AK Abstract OBJECTIVE: This study aimed to: assess the mucosal alterations of the larynx and hypopharynx typical for mucopolysaccharidoses, in a standardised manner; compare the severity in […]
Simultaneous cochlear implantation and labyrinthectomy for advanced Ménière’s disease.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Simultaneous cochlear implantation and labyrinthectomy for advanced Ménière’s disease. J Laryngol Otol. 2015 Dec 17;:1-3 Authors: Heywood RL, Atlas MD Abstract BACKGROUND: Patients with Ménière’s disease can develop unaidable sensorineural hearing loss. Cochlear implantation has recently been utilised in this group with favourable results. A more challenging group are those with intractable vertigo, and they […]
Cancers, Vol. 7, Pages 2466-2485: Oncogenic MicroRNAs: Key Players in Malignant Transformation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
MicroRNAs (miRNAs) represent a class of non-coding RNAs that exert pivotal roles in the regulation of gene expression at the post-transcriptional level. MiRNAs are involved in many biological processes and slight modulations in their expression have been correlated with the occurrence of different diseases. In particular, alterations in the expression of miRNAs with oncogenic or […]
Gastrointestinal motility during sleep assessed by tracking of telemetric capsules combined with polysomnography – a pilot study.
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Gastrointestinal motility during sleep assessed by tracking of telemetric capsules combined with polysomnography – a pilot study. Clin Exp Gastroenterol. 2015;8:327-332 Authors: Haase AM, Fallet S, Otto M, Scott SM, Schlageter V, Krogh K Abstract Studies of gastrointestinal function during sleep are hampered by lack of applicable techniques. Recent development of a novel ambulatory telemetric […]
IJMS, Vol. 16, Pages 30223-30250: Applications of Micro-Fourier Transform Infrared Spectroscopy (FTIR) in the Geological Sciences—A Review
Fourier transform infrared spectroscopy (FTIR) can provide crucial information on the molecular structure of organic and inorganic components and has been used extensively for chemical characterization of geological samples in the past few decades. In this paper, recent applications of FTIR in the geological sciences are reviewed. Particularly, its use in the characterization of geochemistry and thermal maturation of organic matter in coal and shale is addressed. These investigations demonstrate that the employment of high-resolution micro-FTIR imaging enables visualization and ma...περισσότερα »
Comparison of Transcutaneous and Capillary Measurement of PCO2 in Hypercapnic Subjects
BACKGROUND:Measurement of PCO2 is vital in determining effective alveolar ventilation. However, obtaining capillary PCO2 by a skin prick of the earlobe is painful, and nocturnal measurements disturb sleep. End-expiratory measurement of PCO2 is also well established, but there is a low precision in predicting arterial or capillary CO2. The purpose of the study was to evaluate nocturnal measurement of noninvasive, transcutaneous PCO2 (PtcCO2) measurement in hypercapnic subjects.METHODS:In this prospective study, 31 subjects with chronic hypercapnic failure—in a stable phase of the u...περισσότερα »
Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation
BACKGROUND:An increasing number of centers are using active rehabilitation and ambulation for critically ill patients on extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation. This investigation assessed the economic impact at a single center of ambulatory versus non-ambulatory ECMO strategies as a bridge to lung transplantation.METHODS:We conducted a single-center retrospective cohort analysis of all subjects supported with ECMO as a bridge to lung transplantation (N = 9) from 2007 to 2012. Subjects who were rehabilitated while supported with ECMO before ... περισσότερα »
Applying the Transtheoretical Model to Physical Activity Behavior in Individuals With Non-Cystic Fibrosis Bronchiectasis
BACKGROUND:The transtheoretical model has been successful in promoting health behavior change in general and clinical populations. However, there is little knowledge about the application of the transtheoretical model to explain physical activity behavior in individuals with non-cystic fibrosis bronchiectasis. The aim was to examine patterns of (1) physical activity and (2) mediators of behavior change (self-efficacy, decisional balance, and processes of change) across stages of change in individuals with non-cystic fibrosis bronchiectasis.METHODS:Fifty-five subjects with non-cyst... περισσότερα »
Excess maternal fructose consumption increases fetal loss and impairs endometrial decidualization in mice
Endocrinology, Early Release. from Endocrinology via ola Kala on Inoreader http://ift.tt/1QQPXIm via IFTTT
High tumor glycine concentration is an adverse prognostic factor in locally advanced rectal cancer
Publication date: Available online 17 December 2015 *Source:*Radiotherapy and Oncology Author(s): Kathrine Røe Redalen, Beathe Sitter, Tone Frost Bathen, Krystyna K. Grøholt, Knut Håkon Hole, Svein Dueland, Kjersti Flatmark, Anne Hansen Ree, Therese Seierstad Background and purposeRecognizing the link between altered tumor metabolism and disease aggressiveness, this study aimed to identify associations between tumor metabolic profiles and therapeutic outcome in locally advanced rectal cancer (LARC).Materials and methodsPretreatment tumor metabolic profiles from 54 LARC patients rece... περισσότερα »
Carotid intima-medial thickness as a marker of radiation-induced carotid atherosclerosis
Publication date: Available online 17 December 2015 *Source:*Radiotherapy and Oncology Author(s): Dorothy M. Gujral, Benoy N. Shah, Navtej S. Chahal, Sanjeev Bhattacharyya, James Hooper, Roxy Senior, Kevin J. Harrington, Christopher M. Nutting PurposeArterial thickening is a precursor to atherosclerosis. Carotid intima-medial thickness (CIMT), a measure of arterial thickening, is a validated surrogate for prediction of cerebrovascular events. This study investigates CIMT as an early marker of radiation-induced carotid artery damage.Materials/methodsHead and neck cancer patients trea... περισσότερα »
Editorial Board
Publication date: December 2015 *Source:*Radiotherapy and Oncology, Volume 117, Issue 3 from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1T5upH6 via IFTTT
Superficial circumflex iliac artery perforator flap imaging, anatomy, and clinical applications in oral maxillofacial reconstruction
Publication date: Available online 18 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Yue He, Shufang Jin, Zhuowei Tian, Zao Fang, Chunyue Ma, Xiaofeng Tao, Yixin Zhang, Weiliu Qiu, Zhiyuan Zhang, Chenping Zhang PurposeTo assess the feasibility of superficial circumflex iliac artery perforator (SCIP) flap for oral maxillofacial reconstruction and evaluate computed tomography angiography (CTA) and color Doppler sonography (CDS) in mapping superficial circumflex iliac artery (SCIA) and its perforators.Material and MethodsFifteen patients were carried out surge...περισσότερα »
A clinical study of the outcomes and complications associated with zygomatic buttress block bone graft for limited preimplant augmentation procedures
Publication date: Available online 17 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Andreas Sakkas, Alexander Schramm, Winter Karsten, Nils-Claudius Gellrich, Frank Wilde PurposeThe aim of this study was to evaluate the possibility of using the zygomatic buttress as an intraoral bone harvesting donor site and determine the safety of this harvesting procedure for later optimal positioning of dental implants in accordance with prosthodontic and functional principles.Material and MethodsA consecutive retrospective study was conducted on patients who had been... περισσότερα »
Change in mandibular body height at the site of a fixation plate in the advance (lengthening) and setback (shortening) sides after sagittal split ramus osteotomy
Publication date: Available online 17 December 2015 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Koichiro Ueki, Kunio Yoshizawa, Akinori Moroi, Ran Iguchi, Akihiko Kosaka, Hiroumi Ikawa, Takamitsu Tsutsui, Yuriko Saida, Asami Hotta PurposeThe purpose of this study was to evaluate changes in mandibular body height at the site of a fixation plate in the advance (lengthening) and setback (shortening) sides after sagittal split ramus osteotomy (SSRO).Subjectsand Methods: The subjects were 49 patients (98 sides) who underwent bilateral SSRO surgery. The subjects were divide...περισσότερα »
Five putative nucleoside triphosphate diphosphohydrolase genes are expressed in Trichomonas vaginalis
*Trichomonas vaginalis* is a protozoan that parasitizes the human urogenital tract causing trichomoniasis, the most common non-viral sexually transmitted disease. The parasite has unique genomic characteristics such as a large genome size and expanded gene families. Ectonucleoside triphosphate diphosphohydrolase (E-NTPDase) is an enzyme responsible for hydrolyzing nucleoside tri- and diphosphates and has already been biochemically characterized in *T. vaginalis*. Considering the important role of this enzyme in the production of extracellular adenosine for parasite uptake, we eval...περισσότερα »
Restraining of reactive oxygen species promotes invasion of Listeria monocytogenes into glia cells
*Listeria monocytogenes* is a foodborne pathogen that could cause severe infection in the central nervous system of humans and animals. However, the molecular mechanism of the pathogenesis is not fundamentally assessed. This study aimed to analyze the role of reactive oxygen species (ROS) in *L. monocytogenes* during its invasion into glia cells. The ROS level in *L. monocytogenes* was manipulated using NAD(P)H oxidase inhibitor diphenyleneiodonium chloride (DPI) and ROS scavenger N-acetyl cysteine (NAC). Results showed that the invasiveness of *L. monocytogenes* was elevated when... περισσότερα »
Antibacterial properties of biosurfactants against selected Gram-positive and -negative bacteria
The antibacterial properties and ability to disrupt biofilms of biosurfactants (rhamnolipids, sophorolipids) and sodium dodecyl sulphate (SDS) in the presence and absence of selected organic acids were investigated. *Pseudomonas aeruginosa* PAO1 was inhibited by sophorolipids and SDS at concentrations >5% v/v, and the growth of *Escherichia coli* NCTC 10418 was also inhibited by sophorolipids and SDS at concentrations >5% and 0.1% v/v, respectively. *Bacillus subtilis* NCTC 10400 was inhibited by rhamnolipids, sophorolipids and SDS at concentrations >0.5% v/v of all three; the sam...περισσότερα »
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