Effects of N2O narcosis on the contraction and repayment of an oxygen debt., Here’s why the drug that..
Switch to one email a week Unsubscribe from daily digest Hi Alexandros G. Sfakianakis, This daily digest contains latest stories from the sites you've added on Feedspot. View All New Stories Feedspot review RSS Reader App The first 25 results of your Europe PMC Search Remove Effects of N2O narcosis on the contraction and repayment of an oxygen debt. 5 days ago . Save . Twitter No abstract supplied. Read More → Oral Cancer News Remove Here's why the drug that helped Jimmy Carter get 'cancer-free' is such a big deal by Oral Cancer Foundation News Team - A, 10 ho... περισσότερα »
Lithium Battery Diaper Ulceration
Abstract We report a case of lithium battery diaper ulceration in a 16-month-old girl. Gastrointestinal and ear, nose, and throat lesions after lithium battery ingestion have been reported, but skin involvement has not been reported to our knowledge. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1HUhCXv via IFTTT
Eruptive Hypomelanosis in a Young Child as a “Paraviral Exanthem”
Abstract We recently reported a wave of nine children with a novel paraviral exanthem, which we have termed eruptive hypomelanosis. We subsequently witnessed a second wave of children with this exanthem and present a patient here to alert clinicians. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1HUhCXp via IFTTT
Acquired Epidermodysplasia Verruciformis Associated with Human Papilloma Virus Type 14 in a Small Bowel Transplanted Child—A Case Report
Abstract A 3-year-old African American girl taking sirolimus and tacrolimus for a small bowel transplantation presented with hypopigmented macules and papules throughout her trunk. A biopsy diagnosed epidermodysplasia verruciformis (EV) that was found to be associated with human papillomavirus (HPV) type 14 according to polymerase chain reaction analysis. There are few cases of acquired EV in the setting of organ transplantation. Although there is no standardized treatment for acquired EV, prevention and surveillance for transformation to squamous cell carcinoma are primary concer... περισσότερα »
Gaucher Disease Type 2 Presenting with Collodion Membrane and Blueberry Muffin Lesions
Abstract Collodion membrane is most closely associated with forms of autosomal recessive congenital ichthyosis, but the differential diagnosis includes many other less common etiologies. Herein we present a case of Gaucher disease (GD) type 2 in a neonate presenting with collodion membrane in addition to blueberry muffin lesions. The clinical presentation and etiology of GD and the differential diagnoses for collodion membrane and blueberry muffin lesions are briefly reviewed. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1U1PGlI via IFTTT
Neonatal Blue Light Phototherapy and Melanocytic Nevus Count in Children: A Systematic Review and Meta-Analysis of Observational Studies
Abstract Background Neonatal blue light phototherapy (NBLP) is an established method of managing neonatal hyperbilirubinemia. Approximately 5% of newborns are exposed to NBLP. Evidence of whether NBLP predisposes to the development of melanocytic nevi later in life has been conflicting. Objectives The goal of the current study was to conduct a systematic review and meta-analysis to quantitatively assess the effect of NBLP on melanocytic nevus count. Methods We searched for observational studies in Medline, EMBASE, and the Cochrane Central Register from their inception to April ...περισσότερα »
These new articles for Endocrinology are available online
These new articles for Endocrinology are available online ------------------------------ Early Release Endocrinology ------------------------------ [image: Endocrinology masthead] ------------------------------ ------------------------------ Endocrinology Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Unique Distal Enhancers Linked to the Mouse Tnfsf11 Gene Direct Tissue-Specific and Inflammation-induced Expression of RANKL M. Onal, et al. | Endocrinology | Dec 8, 2015Ph... περισσότερα »
KI-coordinated EU network establishes cancer partnerships
EurocanPlatform, an EU-funded network coordinated by Karolinska Institutet, held its last meeting in Brussels in November. The outcome was new collaborative ventures between cancer centres in Europe designed to transfer scientific discoveries from lab to clinic. Five years ago, 28 leading European cancer research institutions and cancer organisations came together in an EU-funded venture called the EurocanPlatform project in order to advance both research into and the treatment of the disease by coordinating European cancer research, sharing infrastructure and participating in joi... περισσότερα »
Link between PCOS in the mother and autism in the child
Children born to mothers with polycystic ovarian syndrome, PCOS, are at an increased risk of developing autism spectrum disorders, according to a new epidemiological study from Karolinska Institutet. The findings, which are published in the journal Molecular Psychiatry, support the notion that exposure to sex hormones early in life may be important for the development of autism in both sexes. The new study is the first report that demonstrates a link between maternal polycystic ovarian syndrome, PCOS, and autism spectrum disorders, ASD, in children. ASD represent a range of neurod...περισσότερα »
The stereotactic frame for biopsies of cerebellar and brainstem lesions
Oblique positioning of via World Neurosurgery Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Johanna Quick-Weller, Stephan Duetzmann, Bedjan Behmanesh, Volker Seifert, Lutz M. Weise, Gerhard Marquardt Highlights Frame based stereotactic biopsy and resulting diagnosis has a high impact on further treatment of patients. Cerebellar and brainstem lesions were not easy to access in the past due to pins, hampering the surgeon’s access. Oblique positioning of the stereotactic frame allows safe and straightforward approach to cerebellar and brainstem... περισσότερα »
Facial Nerve Outcome and Tumor Control Rate as a Function of Degree of Resection in Treatment of Large Acoustic Neuromas: Preliminary Report of the Acoustic Neuroma Subtotal Resection Study.
Facial Nerve Outcome and Tumor Control Rate as a Function of Degree of Resection in Treatment of Large Acoustic Neuromas: Preliminary Report of the Acoustic Neuroma Subtotal Resection Study.: BACKGROUND: Patients with large vestibular schwannomas are at high risk of poor facial nerve (cranial nerve VII [CNVII]) function after surgery. Subtotal resection potentially offers better outcome, but may lead to higher tumor regrowth. OBJECTIVE: To assess long-term CNVII function and tumor regrowth in patients with large vestibular schwannomas. METHODS: Prospective multicenter nonrandomized co... περισσότερα »
Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage
Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis.: BACKGROUND: The prevalence of hypothalamic-pituitary dysfunction after aneurysmal subarachnoid hemorrhage has not been precisely determined, and conflicting results have been reported in the literature. OBJECTIVE: To perform a systematic review and meta-analysis investigating the prevalence of pituitary insufficiency after aneurysmal subarachnoid hemorrhage and to focus on basal serum and dynamic test differences. METHODS: The prevalence of pituitary dysfunction was quantified at 3 ... περισσότερα »
Radiation Therapy for Residual or Recurrent Atypical Meningioma
Radiation Therapy for Residual or Recurrent Atypical Meningioma: The Effects of Modality, Timing, and Tumor Pathology on Long-Term Outcomes.: BACKGROUND: Optimal use of stereotactic radiosurgery (SRS) vs external beam radiation therapy (EBRT) for treatment of residual/recurrent atypical meningioma is unclear. OBJECTIVE: To analyze features associated with progression after radiation therapy. METHODS: Fifty radiation-naive patients who received SRS or EBRT for residual and/or recurrent atypical meningioma were examined for predictors of progression using Cox regression and Kaplan-Meie...περισσότερα »
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation: AbstractTargeting the tumor microenvironment focusing on immune cells has recently become a standard of care for some tumors. Indeed, antibodies blocking immune checkpoints (e.g., anti-CTLA-4 and anti-PD1 mAbs) have been approved by regulatory agencies for the treatment of some solid tumors based upon successes in many clinical trials. Although tumor metabolism has always attracted the attention of tumor biologists, only recently have oncologists renewed their interest in this field of tumor ...περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma: AbstractRecombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cell...περισσότερα »
Functional asymmetry in sensory discrimination in visually blind and its association to braille reading
Functional asymmetry in sensory discrimination in visually blind and its association to braille reading: 2015-12-08T22-49-59Z *Source:* International Journal of Research in Medical Sciences Rohan P.Choraghe, Chitra Pillai. Background: In health, human somatosensory modality is symmetrically distributed. But highly specialised functions like skilled movements, visual sensation while reading show lateralisation. In visually blind population somatosensory modality is used for specialised function like braille reading. Thus present study was undertaken to assess somatosensory modality... περισσότερα »
Analysis of characteristics of semantics of spoken language in normally developing Hindi speaking children
Analysis of characteristics of semantics of spoken language in normally developing Hindi speaking children: 2015-12-08T22-49-59Z *Source:* International Journal of Research in Medical Sciences Anjali R. Kant, Bisma S. Dafadar, Arun A. Banik. Background: There appears to be a lack of database of and dearth of studies focusing on the characteristics of semantics in Hindi speaking school aged children. Such a data base will be useful for building vocabulary for language disordered children and for constructing AAC boards for non-verbal children. Hence, it is essential to study the cha... περισσότερα »
Seroprevalence of hepatitis B antigenemia
Seroprevalence of hepatitis B antigenemia among dental students in a private South Indian dental institution: 2015-12-08T22-49-59Z *Source:* International Journal of Research in Medical Sciences Bhuvan Nagpal, Usha Hegde, Madhuri Kulkarni. Background: Hepatitis B is the most important infectious occupational disease for the dental health care workers (DHCWs). DHCWs frequently come in contact with blood and saliva and hence are at risk for Hepatitis B virus (HBV) exposure. Studies indicate that DHCWs, through occupational exposure, may have a 10 times greater risk of becoming a chro...περισσότερα »
The prevalence of anti-thyroid peroxidase antibodies in subclinical and clinical hypothyroid patients
The prevalence of anti-thyroid peroxidase antibodies in subclinical and clinical hypothyroid patients: 2015-12-08T22-49-59Z *Source:* International Journal of Research in Medical Sciences Jayashankar C.A., Avinash S., Shashidharan B., Vijaya Sarathi., Shruthi K.R., Nikethan D., Harshavardhan J.. Background: Subclinical hypothyroidism is a state of mild thyroid failure and is essentially a laboratory diagnosis with elevated serum thyroid stimulating hormone (TSH) and a normal free thyroxine (FT4) concentration. The main objective of study is to evaluate the prevalence of anti-thyroi... περισσότερα »
Oral administration of Lactobacillus paracasei NCC 2461 for the modulation of grass pollen allergic rhinitis
Oral administration of Lactobacillus paracasei NCC 2461 for the modulation of grass pollen allergic rhinitis: a randomized, placebo-controlled study during the pollen season: Background: The efficacy of Lactobacillus paracasei NCC 2461 in modulating allergic rhinitis was previously evaluated in two exploratory clinical studies. Oral administration with NCC 2461 reduced specific subjective symptoms following nasal provocation tests with controlled grass pollen allergen concentrations. Our aim was to confirm the anti-allergic effect of NCC 2461 in grass pollen allergic subjects exposed... περισσότερα »
Triplication of 16p12.1p12.3 associated with developmental and growth delay and distinctive facial features
Triplication of 16p12.1p12.3 associated with developmental and growth delay and distinctive facial features: The 16p12 region is particularly prone to genomic disorders due to the large number of low copy repeats [Martin et al., 2004; Nature 432:988–994]. We report two unrelated patients with de novo triplication of 16p12.1p12.3 who had developmental delay and similar facial features. Patient 1 is a 4-year-old male with a congenital heart anomaly, bilateral cryptorchidism, chronic constipation, and developmental delay. Patient 2 is a 12-year-old female with prenatally diagnosed hyd... περισσότερα »
Gemcitabine in patients previously treated with platinum-containing chemotherapy for refractory thymic carcinoma: radiographic assessment using the RECIST criteria and the ITMIG recommendations
Gemcitabine in patients previously treated with platinum-containing chemotherapy for refractory thymic carcinoma: radiographic assessment using the RECIST criteria and the ITMIG recommendations: Abstract BackgroundThe key drugs for chemotherapy of thymic carcinoma are gradually being revealed in phase II and conventional retrospective studies. Gemcitabine is regarded as one of these key drugs according to the findings of clinical trials in which it was combined with capecitabine. However, the activity of single-agent gemcitabine concerning refractory thymic carcinoma remains uncle...περισσότερα »
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups
Gene-based pleiotropy across migraine with aura and migraine without aura patient groups: Introduction It is unclear whether patients diagnosed according to International Classification of Headache Disorders criteria for migraine with aura (MA) and migraine without aura (MO) experience distinct disorders or whether their migraine subtypes are genetically related. Aim Using a novel gene-based (statistical) approach, we aimed to identify individual genes and pathways associated both with MA and MO. Methods Gene-based tests were performed using genome-wide association summary statis... περισσότερα »
Pedicled partial thickness clavicular graft for oromandibular reconstruction
Pedicled partial thickness clavicular graft for oromandibular reconstruction via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 121, Issue 1 Author(s): Wenquan Zhao, Jianhua Liu, Dong Wei, Junhua Xu, Huiming Wang ObjectiveTo report our experience on pedicled partial-thickness clavicular graft (PPCG) for oromandibular reconstruction.Study DesignPPCG was used for oromandibular reconstruction after tumor resection in 23 patients with early-stage gingival carcinoma ... περισσότερα »
Intraoperative frozen sections
The influence of intraoperative frozen section analysis in patients with total or extended maxillectomy via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 121, Issue 1 Author(s): James Murphy, Amal Isaiah, Jeffrey S. Wolf, Joshua E. Lubek BackgroundIntraoperative frozen sections and final pathology may influence treatment with regards to intraoperative and postoperative treatments, respectively.Study DesignA retrospective study comparing intraoperative frozen s...περισσότερα »
Head and neck trauma
Predictors of mortality, hospital utilization, and the role of race in outcomes in via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 121, Issue 1 Author(s): Mark Jesin, Stephanie Rashewsky, Michael Shapiro, William Tobler, Suresh Agarwal, Peter Burke, Andrew Salama ObjectiveA retrospective cross-sectional analysis was undertaken to determine the impact of race and insurance status on trauma outcomes in patients admitted to a Level I trauma center following he... περισσότερα »
Swollen and ulcerated maxillary gingivae
Swollen and ulcerated maxillary gingivae via Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology Publication date: January 2016 *Source:*Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 121, Issue 1 Author(s): Amarpreet Sabharwal, Karthik Ganapathi, Michael N. Hatton, Alfredo Aguirre Swollen and ulcerated maxillary gingivae Amarpreet Sabharwal, BDS, MS,a Karthik Ganapathi, MBBS, PhD,b Michael N. Hatton, DDS, MS,c and Alfredo Aguirre, DDS, MSd University at Buffalo, The State University of New York, Buffalo, New York, and Columbia University Medical Cen... περισσότερα »
Platelet-rich fibrin on bone regeneration in diabetics
Evaluation of the effects of platelet-rich fibrin on bone regeneration in diabetic rabbits: This study aimed to investigate the effect of platelet-rich fibrin on bone regeneration in critical size defects in the calvaria of diabetic rabbits. AbstractObjectives This study aimed to investigate the effect of platelet-rich fibrin on bone regeneration in critical size defects in the calvaria of diabetic rabbits. Study Design In total, 40 male New Zealand rabbits, were divided into two groups a non-diabetic control group (Group A) and a diabetic experimental group (Group B). Two bicorti... περισσότερα »
Free Flap Reconstruction for Patients with Bisphosphonate Related Osteonecrosis of the Jaws after Mandibulectomy
Free Flap Reconstruction for Patients with Bisphosphonate Related Osteonecrosis of the Jaws after Mandibulectomy: Bisphosphonate related osteonecrosis of the jaws (BRONJ) is a recognised unwanted effect of these drugs which affect bone remodelling. Treatment options range from conservative approaches through local bone debridement to free flap reconstruction following segmental resection. This current study aims to evaluate clinical outcomes after microvascular tissue transfer in BRONJ patients.
The Gorham-Stout syndrome is a rare condition in which spontaneous, progressive resorption of bone occurs
Case Report: Gorham-Stoute Syndrome with Involvement of Majority of Mandible, and Partial Maxillary, Temporal and Zygomatic Bones: AbstractThe Gorham-Stout syndrome is a rare condition in which spontaneous, progressive resorption of bone occurs. The diagnosis is based on clinical, radiological and histopathological findings after excluding other etiologies and as a result it is often delayed. We present the case of a 21-year-old male diagnosed with Gorham-Stout syndrome with involvement of the majority of the mandible, partial involvement of right maxillary, temporal and zygomatic ... περισσότερα »
Osteotomising the fibular free flap
Osteotomising the fibular free flap: an anatomical perspective: Multiple osteotomies with the help of 3-dimensional planning have improved the accuracy of reconstructions, and the reliability and versatility of the fibular free flap is well recognised. To investigate the periosteal blood supply of the fibula and to define safe limits for the size of bony segments, we performed a cadaveric study on 10 fresh frozen lower limbs using a combined barium latex mixture. We modelled cuts at intervals of 1.0, 1.5, and 2.0cm, and assessed the number of periosteal vessels.
Description of total population hospital admissions for cleft lip and/or palate
Description of total population hospital admissions for cleft lip and/or palate in Australia: Abstract BackgroundOrofacial clefts are a group of frequently observed congenital malformations often requiring multiple hospital admissions over the lifespan of affected individuals. The aim of this study was to describe the total-population hospital admissions with principal diagnosis of cleft lip and/or palate in Australia over a 10 year period. MethodsData for admissions to hospitals were obtained from the Australian Institute of Health and Welfare National Hospital Morbidity Databa... περισσότερα »
Statistical considerations on prognostic models for glioma
Given the lack of beneficial treatments in glioma, there is a need for prognostic models for therapeutic decision making and life planning. Recently several studies defining subtypes of glioma have been published. Here, we review the statistical considerations of how to build and validate prognostic models, explain the models presented in the current glioma literature, and discuss advantages and disadvantages of each model. The 3 statistical considerations to establishing clinically useful prognostic models are: study design, model building, and validation. Careful study design he... περισσότερα »
interNational Anaplastic Thyroid Cancer Tissue Bank and Database (iNATT)
interNational Anaplastic Thyroid Cancer Tissue Bank and Database (iNATT): *Condition*: Anaplastic Thyroid Cancer *Intervention*: Other: Tissue, blood and clinical data collection *Sponsor*: Velindre NHS Trust Anaplastic thyroid cancer has historically proven very difficult to research due to a combination of its rarity and the associated short survival period for those affected. In 2009, 2340 patients in the UK were diagnosed with thyroid cancer with 70-90 expected to be the anaplastic subtype 1,2. For these patients average life expectancy is in the range of 2-6 months wit... περισσότερα »
Patritumab in Combination With Cetuximab and a Platinum Containing Therapy for Patients With Head and Neck Cancer
A Study Using Patritumab in Combination With Cetuximab and a Platinum Containing Therapy for Patients With Head and Neck Cancer: *Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: patritumab; Drug: Cetuximab; Drug: Cisplatin; Drug: Carboplatin *Sponsor*: Daiichi Sankyo Inc. The purpose of this study is to test a study drug called patritumab. Patritumab may work when combined with other medications that are approved in the UK for treating Squamous Cell Carcinoma of the Head and Neck (SCCHN), called cetuximab, cisplatin or carboplatin. It i... περισσότερα »
interNational Anaplastic Thyroid Cancer Tissue Bank and Database (iNATT)
interNational Anaplastic Thyroid Cancer Tissue Bank and Database (iNATT): *Condition*: Anaplastic Thyroid Cancer *Intervention*: Other: Tissue, blood and clinical data collection *Sponsor*: Velindre NHS Trust Anaplastic thyroid cancer has historically proven very difficult to research due to a combination of its rarity and the associated short survival period for those affected. In 2009, 2340 patients in the UK were diagnosed with thyroid cancer with 70-90 expected to be the anaplastic subtype 1,2. For these patients average life expectancy is in the range of 2-6 months wit... περισσότερα »
DCE-MRI-based Dose Escalation for Poor-prognosis and Neck Cancer
Randomized Phase II Study of DCE-MRI-based Dose Escalation for Poor-prognosis and Neck Cancer: *Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: Cisplatin; Drug: Carboplatin; Radiation: IMRT (Intensity-Modulated Radiation Therapy); Radiation: Boost Radiation to Hypoperfused Volumes *Sponsor*: University of Michigan Cancer Center This study aims to improve locoregional control of poor prognosis Head and Neck Cancer (HNC) patients by selectively escalating the radiotherapy dose to subvolumes of tumor likely to be resistant to standard Radi...περισσότερα »
The better to eat you with: the comparative feeding morphology of phocid seals (Pinnipedia, Phocidae)
Abstract One adaptation crucial to the survival of mammalian lineages that secondarily transitioned from land to water environments was the ability to capture and consume prey underwater. Phocid seals have evolved diverse feeding strategies to feed in the marine environment, and the objectives of this study were to document the specialized feeding morphologies and identify feeding strategies used by extant phocids. This study used principal component analysis (PCA) to determine the major axes of diversification in the skull for all extant phocid taxa and the recently extinct Carib... περισσότερα »
The better to eat you with: the comparative feeding morphology of phocid seals (Pinnipedia, Phocidae)
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 45 δευτερόλεπτα
Abstract One adaptation crucial to the survival of mammalian lineages that secondarily transitioned from land to water environments was the ability to capture and consume prey underwater. Phocid seals have evolved diverse feeding strategies to feed in the marine environment, and the objectives of this study were to document the specialized feeding morphologies and identify feeding strategies used by extant phocids. This study used principal component analysis (PCA) to determine the major axes of diversification in the skull for all extant phocid taxa and the recently extinct Carib... περισσότερα »
Effects of Mulligan's Technique in Subjects With Shoulder Impingement Syndrome
Effects of Mulligan's Technique in Subjects With Shoulder Impingement Syndrome: *Condition*: Shoulder Impingement Syndrome *Interventions*: Other: Mobilization with Movement (MWM) condition/ Sham condition; Other: Sham condition/ Mobilization with Movement (MWM) condition *Sponsors*: Universidade Federal de Sao Carlos; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Participants will be initially assessed for their suitability for inclusion in the study and will undergo a physical screening of the affected shoulder and cervical spine by an experienced physi...περισσότερα »
Valproic Acid Plus Cisplatin and Cetuximab in Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck
Valproic Acid Plus Cisplatin and Cetuximab in Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck: *Condition*: Squamous Cell Carcinoma of the Head and Neck *Interventions*: Drug: Valproic Acid; Drug: Cisplatin; Drug: Cetuximab *Sponsor*: National Cancer Institute, Naples *Recruiting* - verified December 2015 V-CHANCE is a phase 2, trial exploring the feasibility and the activity of valproic acid (VPA) in combination with the standard cisplatin-cetuximab combination in patients with recurrent/metastatic squamous cell carcinoma of the head and neck, nev... περισσότερα »
Bestimmung elastischer Eigenschaften von Plattenepithelkarzinomzellen mittels Rasterkraftmikroskopie
Bestimmung elastischer Eigenschaften von Plattenepithelkarzinomzellen mittels Rasterkraftmikroskopie: Laryngo-Rhino-Otol DOI: 10.1055/s-0035-1564213 Einleitung: Maligne und benigne Zellen unterscheiden sich nach bisherigen Untersuchungen durch ihre Kern-Plasma-Relation und an Hand ihrer Elastizität. Zur Messung dieser mechanischen Zelleigenschaft eignet sich die Anwendung eines Rasterkraftmikroskops. Wenn Zellen verschiedener Dignität ein unterschiedliches Resonanzverhalten zeigen, weil sie eine andere Elastizität besitzen, wäre eine selektive Ablation von spezifischen Gewebearten... περισσότερα »
Zur Beurteilung der Therapieerfolge bei dysphonen Patienten
Zur Beurteilung der Therapieerfolge bei dysphonen Patienten: Laryngo-Rhino-Otol DOI: 10.1055/s-0041-107560 Einleitung: Die multidimensionale Stimmdiagnostik gilt als Goldstandard in der Stimmmedizin. Zur standardisierten Evaluation wurde diesbezüglich ein Protokoll der Europäisch Laryngologischen Gesellschaft (ELS-Protokoll) vorgeschlagen. Hinsichtlich der Beurteilung von Therapieverläufen liegen nach wie vor wenige Daten vor. Material und Methoden: 276 Patienten (136 mit phonochirurgischer Operation, 81 mit Stimmtherapie und 59 als stimmgesunde Kontrollgruppe) wurden hinsichtlich ...περισσότερα »
Primäre Parotiskarzinome: Einfluss einer zweizeitigen Operation auf das onkologisches Outcome
Primäre Parotiskarzinome: Einfluss einer zweizeitigen Operation auf das onkologisches Outcome: Laryngo-Rhino-Otol DOI: 10.1055/s-0041-107559 Hintergrund: Parotiskarzinome stellen eine seltene Form der Kopf-Hals-Malignome dar. Fortgeschrittene Malignome werden meist als solche erkannt, wohingegen frühe Tumorstadien aufgrund fehlender Malignitätszeichen teils erst nach erfolgter Parotidektomie diagnostiziert werden. In der vorliegenden Studie wird untersucht, ob dieses ungeplante 2-zeitige Vorgehen einen negativen Einfluss auf das Outcome hat. Material und Methoden: Die Studie umfass... περισσότερα »
Nasennebenhöhlenoperation mit gleichzeitiger Rhinoplastik – Indikation, Risiken und Chancen
Nasennebenhöhlenoperation mit gleichzeitiger Rhinoplastik – Indikation, Risiken und Chancen: Laryngo-Rhino-Otol DOI: 10.1055/s-0041-108264 Hintergrund: Bei zunehmendem Nachweis einer, auch subklinischen, chronischen Sinusitis (CRS) durch verbesserte bildgebende Verfahren (CT, DVT) und wachsender Nachfrage vieler Patienten nach einer Korrektur ihrer äußeren Nase aus funktioneller oder kosmetischer Indikation stellt sich nicht selten die Frage nach einer Kombinationsoperation. Patienten und Methoden: Bei 55 Patienten mit chronischer Sinusitis und Deformität des äußeren Nasenskeletts ... περισσότερα »
Chemosensorisch evozierte Atemänderungen während zweier Propofol-induzierter Sedierungsstadien
Chemosensorisch evozierte Atemänderungen während zweier Propofol-induzierter Sedierungsstadien: Laryngo-Rhino-Otol DOI: 10.1055/s-0041-108262 Hintergrund: Die affektive Valenz eines Riechreizes wird in seiner respiratorischen Antwort kodiert. Unangenehme Gerüche verkürzen im Wach- und Schlafzustand die Dauer der Inspiration des ersten Reizatemzuges. Unter medikamentös induzierter Sedierung ist das bisher nicht untersucht worden. Material und Methoden: 13 ASA 1/2-Patienten beiderlei Geschlechts wurden unter Überwachung der Vitalfunktionen während „tiefer“ (EEG-basierter Bispektraler... περισσότερα »
Tratamiento quirúrgico del schwannoma vestibular
. Revisión de 420 casos via Acta Otorrinolaringológica Española Publication date: Available online 8 December 2015 *Source:*Acta Otorrinolaringológica Española Author(s): Miguel Ángel Arístegui Ruiz, Ricardo José González-Orús Álvarez-Morujo, Carlos Martín Oviedo, Fernando Ruiz-Juretschke, Roberto García Leal, Bartolomé Scola Yurrita Introducción y objetivosEl schwannoma vestibular es el tumor más frecuente en el ángulo ponto-cerebeloso. El objetivo de nuestro estudio es reflejar nuestra experiencia en el tratamiento quirúrgico de este tumor.Material y métodosEstudio retrospectivo de 4...περισσότερα »
Stabilization of Total Ossicular Replacement Prosthesis Using Cartilage “shoe” Graft
Stabilization of Total Ossicular Replacement Prosthesis Using Cartilage “shoe” Graft: We aimed to determine the effect of a cartilage shoe graft placed between the foot of the TORP and the stapes footplate on hearing improvement and long-term displacement rates. AbstractPurpose We aimed to determine the effect of a cartilage shoe graft placed between the foot of the TORP and the stapes footplate on hearing improvement and long-term displacement rates. Materials-Methods Patients underwent TORP ossiculoplasty were divided into two groups. The TORP-alone group consisted of 32 patient... περισσότερα »
The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trial
The use of volatile anesthetic agents for long-term critical care sedation (VALTS): study protocol for a pilot randomized controlled trial: Background: Sedatives are administered to 85 % of intensive care unit (ICU) patients. The most commonly used sedatives are intravenous benzodiazepines and propofol. These agents are associated with over-sedation in 40 to 60 % of patients, which can lead to prolonged intubation, delirium and drug-induced hypotension. Evidence is increasing that volatile anesthetic agents are associated with faster extubation times, improved cardiovascular stability... περισσότερα »
Malignant meningitis secondary to oesophageal adenocarcinoma presenting with sensorineural hearing loss: a series of three cases and discussion of the literature
Malignant meningitis secondary to oesophageal adenocarcinoma presenting with sensorineural hearing loss: a series of three cases and discussion of the literature: AbstractMalignant meningitis may rarely present to the otolaryngologist. We report our experience with 3 patients presenting with sudden, progressive bilateral sensorineural hearing loss secondary to malignant meningitis. The primary tumour in all 3 cases was oesophageal adenocarcinoma. All 3 cases were notable for the rapidity of the patients’ clinical deterioration; the interval from presentation to death ranged from 21... περισσότερα »
Gelatin Facial Skin Simulator for Cutaneous Reconstruction
Gelatin Facial Skin Simulator for Cutaneous Reconstruction: Reconstruction of facial defects can be an intimidating endeavor, especially to resident physicians. When local flap reconstruction is preferred, design of the optimal flap can be a difficult choice. Poor selection can lead to unsightly scarring as well as increased morbidity. A low-cost, easy-to-fabricate gelatin prosthetic facial skin simulator is presented to offer training experience in wound closure, local tissue rearrangement, and facial defect reconstruction for resident instruction. In conjunction with a didactic l... περισσότερα »
Shared Decision Making and Choice for Elective Surgical Care: A Systematic Review
Shared Decision Making and Choice for Elective Surgical Care: A Systematic Review: Objective Shared decision making (SDM), an integrative patient-provider communication process emphasizing discussion of scientific evidence and patient/family values, may improve quality care delivery, promote evidence-based practice, and reduce overuse of surgical care. Little is known, however, regarding SDM in elective surgical practice. The purpose of this systematic review is to synthesize findings of studies evaluating use and outcomes of SDM in elective surgery. Data Sources PubMed, Cochrane ...περισσότερα »
Obstructive Sleep Apnea and Gastroesophageal Reflux
Obstructive Sleep Apnea and Gastroesophageal Reflux: A Multivariate Population-Level Analysis: Objectives Previous studies investigating the relationship between gastroesophageal reflux (GER) and obstructive sleep apnea (OSA) demonstrate mixed results and have had limited capacity to control for concurrent confounders. Our objectives were to (1) determine if GER is significantly associated with OSA when simultaneously adjusting for the presence of other potentially confounding conditions and (2) quantify the magnitude of any such association that exists. Study Design Cross-section...περισσότερα »
Decision Making for Children with Obstructive Sleep Apnea without Tonsillar Hypertrophy
Decision Making for Children with Obstructive Sleep Apnea without Tonsillar Hypertrophy: Objective Evidence-based medicine is the gold standard practice model for patient management. Our aim was to determine whether decisions made by pediatric subspecialists regarding management of obstructive sleep apnea in children without tonsillar hypertrophy adhered to this model or were based on clinical experiences. Study Design Single-institution prospective study. Setting Multidisciplinary upper airway center in an academic pediatric hospital. Subjects and Methods Twelve pediatric subsp...περισσότερα »
Incidence of Visualization of the Glossopharyngeal Nerve after Pediatric Tonsillectomy
Incidence of Visualization of the Glossopharyngeal Nerve after Pediatric Tonsillectomy: The objective was to determine the incidence of exposure of the lingual branch of the glossopharyngeal nerve during tonsillectomy with a retrospective review of surgical findings in 138 children who underwent total tonsillectomy at a tertiary medical center. Age, sex, surgical indication, tonsil size, congenital abnormalities, operative time, and surgical findings indicating the presence or absence of the glossopharyngeal nerve in the tonsillar fossa were recorded. Statistical analysis was perf... περισσότερα »
TeamSTEPPS (Team Strategies and Tools to Enhance Performance and Patient Safety) on operating room efficiency for the otolaryngology service
How Does TeamSTEPPS Affect Operating Room Efficiency?: Objective To evaluate the effect of TeamSTEPPS (Team Strategies and Tools to Enhance Performance and Patient Safety) on operating room efficiency for the otolaryngology service at a tertiary care medical center. Study Design Retrospective database review. Setting Otolaryngology department at tertiary care medical center. Subjects and Methods To assess the impact of implementing an evidence-based patient safety initiative, TeamSTEPPS, on operating room efficiency in the otolaryngology department, the operative times, time lost...περισσότερα »
Predicting Dental Caries Outcomes in Children: A "Risky" Concept
In recent years, unprecedented gains in the understanding of the biology and mechanisms underlying human health and disease have been made. In the domain of oral health, although much remains to be learned, the complex interactions between different systems in play have begun to unravel: host genome, oral microbiome with its transcriptome, proteome and metabolome, and more distal influences, including relevant behaviors and environmental exposures. A reasonable expectation is that this emerging body of knowledge can help improve the oral health and optimize care for individuals and...περισσότερα »
FT-Raman Spectroscopy Study of the Remineralization of Microwave-Exposed Artificial Caries
Dental caries is a microbially mediated disease that can result in significant tooth structure degradation. Although the preponderance of lesions is treated by surgical intervention, various strategies have been developed for its noninvasive management. Here, we use a novel approach for noninvasive treatment based on killing *Streptococcus mutans* with high-frequency microwave energy (ME). The rationale for this approach is based on modulating the pH of caries to a physiological state to enable spontaneous tooth remineralization from exogenous sources. In the present study, after ... περισσότερα »
MRI/MRS as a surrogate marker for clinical progression in GM1 Gangliosidosis
Background GM1 gangliosidosis is a lysosomal storage disorder caused by mutations in GLB1, encoding β-galactosidase. The range of severity is from type I infantile disease, lethal in early childhood, to type III adult onset, resulting in gradually progressive neurological symtpoms in adulthood. The intermediate group of patients has been recently classified as having type II late infantile subtype with onset of symptoms at one to three years of age or type II juvenile subtype with symptom onset at 2–10 years. To characterize disease severity and progression, six Late infantile an... περισσότερα »
Triplication of 16p12.1p12.3 associated with developmental and growth delay and distinctive facial features
The 16p12 region is particularly prone to genomic disorders due to the large number of low copy repeats [Martin et al., 2004; Nature 432:988–994]. We report two unrelated patients with de novo triplication of 16p12.1p12.3 who had developmental delay and similar facial features. Patient 1 is a 4-year-old male with a congenital heart anomaly, bilateral cryptorchidism, chronic constipation, and developmental delay. Patient 2 is a 12-year-old female with prenatally diagnosed hydronephrosis, hepatobiliary disease, failure to thrive, and developmental delay. Distinctive facial features ... περισσότερα »
Diversity and Divergence of Dinofagellate Histone Proteins
Histone proteins and the nucleosomal organization of chromatin are near-universal eukaroytic features, with the exception of dinoflagellates. Previous studies have suggested that histones do not play a major role in the packaging of dinoflagellate genomes, although several genomic and transcriptomic surveys have detected a full set of core histone genes. Here, transcriptomic and genomic sequence data from multiple dinoflagellate lineages are analyzed, and the diversity of histone proteins and their variants characterized, with particular focus on their potential posttranslational ... περισσότερα »
A Genome-Wide Screen with Nicotinamide to Identify Sirtuin-Dependent Pathways in Saccharomyces cerevisiae
Sirtuins are evolutionarily conserved NAD-dependent deacetylases that catalyze the cleavage of NAD+ into nicotinamide (NAM), which can act as a pan-sirtuin inhibitor in unicellular and multicellular organisms. Sirtuins regulate processes such as transcription, DNA damage repair, chromosome segregation and longevity extension in yeast and metazoans. The founding member of the evolutionarily conserved sirtuin family, *SIR2*, was first identified in budding yeast. Subsequent studies led to the identification of four yeast *SIR2* homologs *HST1*, *HST2*, *HST3*, and *HST4*. Understand...περισσότερα »
Assessment of Abdominal Fat Graft to Repair Anterior Skull Base after Malignant Sinonasal Tumor Extirpation
Assessment of Abdominal Fat Graft to Repair Anterior Skull Base after Malignant Sinonasal Tumor Extirpation: Objective Adult abdominal fat, which is known to contain pluripotent stem cells, is frequently used to treat cerebrospinal fluid leak. The aim of this study was to assess the efficacy and reliability of abdominal fat graft to close large skull base defects after extirpation of malignant sinonasal tumors. Study Design Case series with chart review performed between 2009 and 2014. Subjects and Methods Twenty-nine cases were included of consecutive patients who were suffering ... περισσότερα »
Experimental validation of a topology optimized acoustic cavity
Experimental validation of a topology optimized acoustic cavity: This paper presents the experimental validation of an acoustic cavity designed using topology optimization with the goal of minimizing the sound pressure locally for monochromatic excitation. The presented results show good agreement between simulations and measurements. The effect of damping, errors in the production of the cavity, and variations in operating frequency is discussed and the importance of taking these factors into account in the modeling process is highlighted.
Level dependence of the nonlinear-distortion component of distortion-product otoacoustic emissions in humansa)
Level dependence of the nonlinear-distortion component of distortion-product otoacoustic emissions in humansa): Distortion-product otoacoustic emissions (DPOAEs) emerge when presenting two primary tones with different frequencies f1 and f2 to the cochlea and are commonly used in diagnosis and research to evaluate the functional state of the cochlea. Optimal primary-tone stimulus levels accounting for the different level dependencies of the traveling-wave amplitudes of the two primary tones near the f2-tonotopic place on the basilar membrane are often used to maximize DPOAE amplitud...περισσότερα »
Inter-individual changes in cortical bone three-dimensional microstructure and elastic coefficient have opposite effects on radial sound speed
Inter-individual changes in cortical bone three-dimensional microstructure and elastic coefficient have opposite effects on radial sound speed: Knowledge about simultaneous contributions of tissuemicrostructure and elastic properties on ultrasound speed in cortical bone is limited. In a previous study, porosities and elastic coefficients of cortical bone in human femurs were shown to change with age. In the present study, influences of inter-individual and site-dependent variation in cortical bone microstructure and elastic properties on radial speed of sound(SOS; at 4, 6, and 8 MH... περισσότερα »
Voice Disorder Management Competencies: A Survey of School-Based Speech-Language Pathologists in Nebraska
Voice Disorder Management Competencies: A Survey of School-Based Speech-Language Pathologists in Nebraska: Purpose The purpose of this survey was to determine the self-perceived competence levels in voice disorders of practicing school-based speech-language pathologists (SLPs) and identify correlated variables. Method Participants were 153 master's level, school-based SLPs with a Nebraska teaching certificate and/or licensure who completed a survey, including demographic information and a 25-item voice disorders competency checklist. Results Findings indicated school-based SLPs d... περισσότερα »
A Quasi-Universal Nonword Repetition Task as a Diagnostic Tool for Bilingual Children Learning Dutch as a Second Language
A Quasi-Universal Nonword Repetition Task as a Diagnostic Tool for Bilingual Children Learning Dutch as a Second Language: Purpose This study evaluated a newly developed quasi-universal nonword repetition task (Q-U NWRT) as a diagnostic tool for bilingual children with language impairment (LI) who have Dutch as a 2nd language. The Q-U NWRT was designed to be minimally influenced by knowledge of 1 specific language in contrast to a language-specific NWRT with which it was compared. Method One hundred twenty monolingual and bilingual children with and without LI participated (30 per... περισσότερα »
Relations Between the Intelligibility of Speech in Noise and Psychophysical Measures of Hearing Measured in Four Languages Using the Auditory Profile Test Battery
Relations Between the Intelligibility of Speech in Noise and Psychophysical Measures of Hearing Measured in Four Languages Using the Auditory Profile Test Battery: The aim of the present study was to determine the relations between the intelligibility of speech in noise and measures of auditory resolution, loudness recruitment, and cognitive function. The analyses were based on data published earlier as part of the presentation of the Auditory Profile, a test battery implemented in four languages. Tests of the intelligibility of speech, resolution, loudness recruitment, and lexical... περισσότερα »
Role of stem cells during diabetic liver injury
Abstract Diabetes mellitus is one of the most severe endocrine metabolic disorders in the world that has serious medical consequences with substantial impacts on the quality of life. Type 2 diabetes is one of the main causes of diabetic liver diseases with the most common being non-alcoholic fatty liver disease. Several factors that may explain the mechanisms related to pathological and functional changes of diabetic liver injury include: insulin resistance, oxidative stress and endoplasmic reticulum stress. The realization that these factors are important in hepatocyte damage and ... περισσότερα »
Predicting Dental Caries Outcomes in Children: A "Risky" Concept
In recent years, unprecedented gains in the understanding of the biology and mechanisms underlying human health and disease have been made. In the domain of oral health, although much remains to be learned, the complex interactions between different systems in play have begun to unravel: host genome, oral microbiome with its transcriptome, proteome and metabolome, and more distal influences, including relevant behaviors and environmental exposures. A reasonable expectation is that this emerging body of knowledge can help improve the oral health and optimize care for individuals and...περισσότερα »
FT-Raman Spectroscopy Study of the Remineralization of Microwave-Exposed Artificial Caries
Dental caries is a microbially mediated disease that can result in significant tooth structure degradation. Although the preponderance of lesions is treated by surgical intervention, various strategies have been developed for its noninvasive management. Here, we use a novel approach for noninvasive treatment based on killing *Streptococcus mutans* with high-frequency microwave energy (ME). The rationale for this approach is based on modulating the pH of caries to a physiological state to enable spontaneous tooth remineralization from exogenous sources. In the present study, after ... περισσότερα »
Relations Between the Intelligibility of Speech in Noise and Psychophysical Measures of Hearing Measured in Four Languages Using the Auditory Profile Test Battery
The aim of the present study was to determine the relations between the intelligibility of speech in noise and measures of auditory resolution, loudness recruitment, and cognitive function. The analyses were based on data published earlier as part of the presentation of the Auditory Profile, a test battery implemented in four languages. Tests of the intelligibility of speech, resolution, loudness recruitment, and lexical decision making were measured using headphones in five centers: in Germany, the Netherlands, Sweden, and the United Kingdom. Correlations and stepwise linear regr... περισσότερα »
Unintended pregnancies observed with combined use of the levonorgestrel contraceptive implant and efavirenz-based antiretroviral therapy: a three-arm pharmacokinetic evaluation over 48 weeks
Compared to an ART-naive group, women receiving efavirenz-based ART had significantly lower levonorgestrel pharmacokinetics, following its release from a subdermal implant. An unexpected high pregnancy rate (3/20, 15%) occurred in the efavirenz group, highlighting the clinical significance of this interaction. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/21NJbrW via IFTTT
Multicolored words:Uncovering the relationship between reading mechanisms and synesthesia
Publication date: Available online 8 December 2015 *Source:*Cortex Author(s): Laura J. Blazej, Ariel M. Cohen-Goldberg Grapheme-color and lexical-color synesthesia, the association of colors with letters and words, respectively, are some of the most commonly studied forms of synesthesia, yet relatively little is known about how synesthesia arises from and interfaces with the reading process. To date, synesthetic experiences in reading have only been reported in relation to a word's graphemes and meaning. We present a case study of WBL, a 21-year old male who experiences synesthetic ...περισσότερα »
Rates and Predictors of Seizure Freedom With Vagus Nerve Stimulation for Intractable Epilepsy.
BACKGROUND: Neuromodulation-based treatments have become increasingly important in epilepsy treatment. Most patients with epilepsy treated with neuromodulation do not achieve complete seizure freedom, and, therefore, previous studies of vagus nerve stimulation (VNS) therapy have focused instead on reduction of seizure frequency as a measure of treatment response. OBJECTIVE: To elucidate rates and predictors of seizure freedom with VNS. METHODS: We examined 5554 patients from the VNS therapy Patient Outcome Registry, and also performed a systematic review of the literature including ... περισσότερα »
Defining a Standardized Approach for the Bedside Insertion of Temporal Horn External Ventricular Drains: Procedure Development and Case Series.
BACKGROUND: A trapped temporal horn can be emergently decompressed by inserting a bedside temporal horn external ventricular drain (tEVD). However, no standardized method for this procedure has been described. OBJECTIVE: To identify methods for bedside tEVD insertion, and determine the safest, most accurate, and most easily standardized approach. METHODS: Volumetric images of 20 patients with trapped temporal horns were analyzed. Three tEVD approaches (perpendicular, lateral, and medial) were defined, along with standardized insertion points and external landmarks for trajectory gui... περισσότερα »
Acute Kidney Injury After Craniotomy Is Associated With Increased Mortality: A Cohort Study.
BACKGROUND: Acute kidney injury (AKI) is a serious postoperative complication. OBJECTIVE: To determine whether AKI in patients after craniotomy is associated with heightened 30-day mortality. METHODS: We performed a 2-center, retrospective cohort study of 1656 craniotomy patients who received critical care between 1998 and 2011. The exposure of interest was AKI defined as meeting RIFLE (Risk, Injury, Failure, Loss of Kidney Function, and End-stage Kidney Disease) class risk, injury, and failure criteria, and the primary outcome was 30-day mortality. Adjusted odds ratios were estimat...περισσότερα »
A Reappraisal of Anterior Communicating Artery Aneurysms: A Case for Stent-Assisted Embolization.
BACKGROUND: Wide-necked anterior communicating artery aneurysms represent a subset of lesions with challenging endovascular treatment despite new endoluminal and intrasaccular devices. OBJECTIVE: To assess the long-term clinical and angiographic outcomes of stent-assisted embolization for wide-necked anterior communicating artery aneurysms. METHODS: Between March 2008 and March 2014, 32 patients with unruptured wide-necked AComm aneurysms were treated using stent-assisted embolization. The Glasgow Outcome Scale was reviewed at the time of discharge and at latest follow-up. Ischemic ... περισσότερα »
Radiation Therapy for Residual or Recurrent Atypical Meningioma: The Effects of Modality, Timing, and Tumor Pathology on Long-Term Outcomes.
BACKGROUND: Optimal use of stereotactic radiosurgery (SRS) vs external beam radiation therapy (EBRT) for treatment of residual/recurrent atypical meningioma is unclear. OBJECTIVE: To analyze features associated with progression after radiation therapy. METHODS: Fifty radiation-naive patients who received SRS or EBRT for residual and/or recurrent atypical meningioma were examined for predictors of progression using Cox regression and Kaplan-Meier analyses. RESULTS: Thirty-two patients (64%) received adjuvant radiation after subtotal resection, 12 patients (24%) received salvage radia...περισσότερα »
Thoracic Myoepithelial Tumors: A Pathologic and Molecular Study of 8 Cases With Review of the Literature.
Thoracic myoepithelial tumors (MTs) are a rare group of tumors showing predominant or exclusive myoepithelial differentiation. They are poorly characterized from both a morphologic and genetic standpoint, in particular features that separate benign from malignant behavior. We examined the histologic and immunohistochemical features of 8 primary thoracic MTs and performed fluorescence in situ hybridization for EWSR1, FUS, PLAG1, and HMGA2, as well as several partner genes. Half (4/8) of the MTs occurred in large airways, and 3 had infiltrative borders. All cases showed immunoreactivi... περισσότερα »
Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST.
Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of NF1, CDKN2A, and polycomb repressive complex 2 component genes (Embryonic Ectoderm Development [EED] and Suppressor of Zeste 12 [SUZ12]). Mutations in EED and SUZ12 induce loss of trimethylation at lysine 27 of histone 3 (H3K27me3), with subsequent aberrant transcriptional activation of polycomb repressive complex 2-repressed homeobox master regulators. These findings prompted us to investigate the performance of an anti-H3K27me3 monoclonal antibody clone C36B11 as an immunohistochemical marker f... περισσότερα »
Lower Female Genital Tract Tumors With Adenoid Cystic Differentiation: P16 Expression and High-risk HPV Detection.
Lower female genital tract tumors with adenoid cystic differentiation are rare, and data on their relationship with high-risk human papillomavirus (HPV) are limited. Here we report the clinicopathologic features from a case series. Tumors with adenoid cystic differentiation, either pure or as part of a carcinoma with mixed differentiation, arising in the lower female genital tract were evaluated by means of immunohistochemical analysis for p16 expression and in situ hybridization using 1 or more probes for high-risk HPV (a high-risk probe covering multiple types, a wide-spectrum pro... περισσότερα »
Pituitary Dysfunction After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-analysis.
BACKGROUND: The prevalence of hypothalamic-pituitary dysfunction after aneurysmal subarachnoid hemorrhage has not been precisely determined, and conflicting results have been reported in the literature. OBJECTIVE: To perform a systematic review and meta-analysis investigating the prevalence of pituitary insufficiency after aneurysmal subarachnoid hemorrhage and to focus on basal serum and dynamic test differences. METHODS: The prevalence of pituitary dysfunction was quantified at 3 to 6 months and >6 months after aneurysmal subarachnoid hemorrhage. Proportions were transformed with ... περισσότερα »
Book Review: Top 3 Differentials in Neuroradiology: A Case Review.
No abstract available from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1NaJeGx via IFTTT
Facial Nerve Outcome and Tumor Control Rate as a Function of Degree of Resection in Treatment of Large Acoustic Neuromas: Preliminary Report of the Acoustic Neuroma Subtotal Resection Study.
BACKGROUND: Patients with large vestibular schwannomas are at high risk of poor facial nerve (cranial nerve VII [CNVII]) function after surgery. Subtotal resection potentially offers better outcome, but may lead to higher tumor regrowth. OBJECTIVE: To assess long-term CNVII function and tumor regrowth in patients with large vestibular schwannomas. METHODS: Prospective multicenter nonrandomized cohort study of patients with vestibular schwannoma >=2.5 cm who received gross total resection, near total resection, or subtotal resection. Patients received radiation if tumor remnant showe... περισσότερα »
The Pipeline Embolization Device: Long-term outcome data flows in
Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Michael M. McDowell, Rafey A. Feroze, Andrew F. Ducruet from Neurology via xlomafota13 on Inoreader http://ift.tt/1m9GVLb via IFTTT
Oblique positioning of the stereotactic frame for biopsies of cerebellar and brainstem lesions
Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Johanna Quick-Weller, Stephan Duetzmann, Bedjan Behmanesh, Volker Seifert, Lutz M. Weise, Gerhard Marquardt from Neurology via xlomafota13 on Inoreader http://ift.tt/1m9GVL5 via IFTTT
Neuroinflammation after Subarachnoid Hemorrhage: A consolidated theory?
Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Leonardo C. Welling, Mariana S. Welling, Manoel J. Teixeira, Eberval G. Figueiredo from Neurology via xlomafota13 on Inoreader http://ift.tt/1m9GX5E via IFTTT
Flow diverters for Treatment of Intracranial Aneurysms: Technical and Clinical Updates
Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Krishna Amuluru, Fawaz Al-Mufti, Paul Inder Singh, Charles Prestigiacomo, Chirag Gandhi from Neurology via xlomafota13 on Inoreader http://ift.tt/1M2lrVt via IFTTT
SEEG, Happy Anniversary!
Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Francesco Cardinale, Jorge González-Martínez, Giorgio Lo Russo from Neurology via xlomafota13 on Inoreader http://ift.tt/1M2lu3p via IFTTT
From Patchell to Brown: An Evidence-Based Evolution of the Role of Radiotherapy on the Management of Brain Metastases
Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Bruno C. Flores, Ankur R. Patel, Robert D. Timmerman, Samuel L. Barnett from Neurology via xlomafota13 on Inoreader http://ift.tt/1M2lrEX via IFTTT
Primary intracranial epidermoid carcinoma with diffuse leptomeningeal carcinomatosis: Report of two cases
Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Amol Raheja, Ilyas M. Eli, Christian A. Bowers, Cheryl Ann Palmer, William T. Couldwell BackgroundMalignant degeneration of epidermoid cyst (EC) with accompanying leptomeningeal carcinomatosis (LC) at presentation is extremely rare. We add two cases to the literature, including the first case of primary brainstem involvement with simultaneous diffuse LC, and discuss clinical and radiological cues to differentiate benign and malignant epidermoid tumors for early diagnosis.Case descriptionA 54-ye...περισσότερα »
Epistemology and Brain Arteriovenous Malformations
Publication date: Available online 8 December 2015 *Source:*World Neurosurgery Author(s): Robert Ecker from Neurology via xlomafota13 on Inoreader http://ift.tt/1m9GTTx via IFTTT
Congenital Ichthyosiform Erythroderma Superimposed with Chronic Dermatophytosis: A Report of Three Siblings
Abstract Congenital ichthyosiform erythroderma is an autosomal recessive ichthyosis characterized by severe scaling and erythroderma. We report a family of three siblings who were all born with a collodion membrane and presented with diffuse scaling and pruritus. All three children subsequently developed chronic cutaneous dermatophyte infections requiring oral antifungals. One child developed superinfection with methicillin-resistant *Staphylococcus aureus* requiring antibiotics. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1PXuuic via IFTTT
"Killing Two Birds With One Stone": Antineoplastic Immunosuppression.
No abstract available from Allergy\Immunology via ola Kala on Inoreader http://ift.tt/1NFsUPD via IFTTT
The Intestinal Microbiome and the Liver Transplant Recipient: What We Know and What We Need to Know.
The intestinal microbiome and immune system are in close symbiotic relationship in health. Gut microbiota plays a role in many chronic liver diseases and cirrhosis. However, alterations in the gut microbiome after liver transplantation and the implications for liver transplant recipients are not well understood and rely mainly on experimental animal studies. Recent advances in molecular techniques have identified that increased intestinal permeability, decreased beneficial bacteria, and increased pathogenic species may play important roles in the early posttransplant period. The ass... περισσότερα »
Marked improvement of neuropsychiatric symptoms following control of allergy symptoms with the use of humanized murine anti-IgE antibody (omalizumab) in 2 patients with severely limited expressive language
[image: s13223-015-0105-x-1.gif] Flare-up of allergic rhinitis has been implicated in worsening neuropsychiatric symptoms such as hyperactivity and anxiety in the general population, mostly supported by epidemiological data. However, it is unknown how such respiratory allergy symptoms affect behavioral symptoms in patients with intellectual disability and limited expressive language. These patients may express more severe behavioral symptoms partly due to frustration and anxiety, being under-diagnosed and undertreated secondary to a lack of proper communication means. Herein, we pr...περισσότερα »
Thoracic Myoepithelial Tumors: A Pathologic and Molecular Study of 8 Cases With Review of the Literature.
Thoracic myoepithelial tumors (MTs) are a rare group of tumors showing predominant or exclusive myoepithelial differentiation. They are poorly characterized from both a morphologic and genetic standpoint, in particular features that separate benign from malignant behavior. We examined the histologic and immunohistochemical features of 8 primary thoracic MTs and performed fluorescence in situ hybridization for EWSR1, FUS, PLAG1, and HMGA2, as well as several partner genes. Half (4/8) of the MTs occurred in large airways, and 3 had infiltrative borders. All cases showed immunoreactivi... περισσότερα »
Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST.
Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of NF1, CDKN2A, and polycomb repressive complex 2 component genes (Embryonic Ectoderm Development [EED] and Suppressor of Zeste 12 [SUZ12]). Mutations in EED and SUZ12 induce loss of trimethylation at lysine 27 of histone 3 (H3K27me3), with subsequent aberrant transcriptional activation of polycomb repressive complex 2-repressed homeobox master regulators. These findings prompted us to investigate the performance of an anti-H3K27me3 monoclonal antibody clone C36B11 as an immunohistochemical marker f... περισσότερα »
A constellation scaling approach to vector perturbation for adaptive modulation in MU-MIMO
Li, A; Masouros, C; (2015) A constellation scaling approach to vector perturbation for adaptive modulation in MU-MIMO. IEEE Wireless Communications Letters , 4 (3) pp. 289-292. 10.1109/LWC.2015.2410271 . Green open access from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1lO2Kzk via IFTTT
Physiological phenotyping of dementias using emotional sounds
Fletcher, PD; Nicholas, JM; Shakespeare, TJ; Downey, LE; Golden, HL; Agustus, JL; Clark, CN; Fletcher, PD; Nicholas, JM; Shakespeare, TJ; Downey, LE; Golden, HL; Agustus, JL; Clark, CN; Mummery, CJ; Schott, JM; Crutch, SJ; Warren, JD; - view fewer (2015) Physiological phenotyping of dementias using emotional sounds. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring , 1 (2) pp. 170-178. 10.1016/j.dadm.2015.02.003 . Green open access from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1XV5j4l via IFTTT
Efficient integration of synaptic events by NMDA receptors in three-dimensional neuropil
Zheng, K; Rusakov, DA; (2015) Efficient integration of synaptic events by NMDA receptors in three-dimensional neuropil. Biophysical Journal , 108 (10) pp. 2457-2464. 10.1016/j.bpj.2015.04.009 . Green open access from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1lO2EYF via IFTTT
KI-coordinated EU network establishes cancer partnerships
EurocanPlatform, an EU-funded network coordinated by Karolinska Institutet, held its last meeting in Brussels in November. The outcome was new collaborative ventures between cancer centres in Europe designed to transfer scientific discoveries from lab to clinic. Five years ago, 28 leading European cancer research institutions and cancer organisations came together in an EU-funded venture called the EurocanPlatform project in order to advance both research into and the treatment of the disease by coordinating European cancer research, sharing infrastructure and participating in joi... περισσότερα »
Link between PCOS in the mother and autism in the child
Children born to mothers with polycystic ovarian syndrome, PCOS, are at an increased risk of developing autism spectrum disorders, according to a new epidemiological study from Karolinska Institutet. The findings, which are published in the journal Molecular Psychiatry, support the notion that exposure to sex hormones early in life may be important for the development of autism in both sexes. The new study is the first report that demonstrates a link between maternal polycystic ovarian syndrome, PCOS, and autism spectrum disorders, ASD, in children. ASD represent a range of neurod...περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Abstract Recombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cells and K-562 human erythroblasts; this was accompanied with increased transport of the endogenous HSP70 to the plasma membrane. Important... περισσότερα »
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation
Abstract Targeting the tumor microenvironment focusing on immune cells has recently become a standard of care for some tumors. Indeed, antibodies blocking immune checkpoints (e.g., anti-CTLA-4 and anti-PD1 mAbs) have been approved by regulatory agencies for the treatment of some solid tumors based upon successes in many clinical trials. Although tumor metabolism has always attracted the attention of tumor biologists, only recently have oncologists renewed their interest in this field of tumor biology research. This has highlighted the possibility to pharmacologically target rate-li... περισσότερα »
Low intratumoral regulatory T cells and high peritumoral CD8 + T cells relate to long-term survival in patients with pancreatic ductal adenocarcinoma after pancreatectomy
Abstract The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Recent studies have focused on the role of lymphocytes in the PDAC microenvironment. Using immunohistochemistry, our study explored the clinical significance of intratumoral or peritumoral CD4+Foxp3+ regulatory T cells (Tregs) and CD8+ T cells in the tumor microenvironment and analyzed their relation to the prognosis of PDAC in a consecutive series of 92 patients after resection. CD8+ T cells were more frequently seen within peritumoral sites, while CD4+Foxp3+ Tregs were more frequent within ...περισσότερα »
Improving cancer immunotherapy with DNA methyltransferase inhibitors
Abstract Immunotherapy confers durable clinical benefit to melanoma, lung, and kidney cancer patients. Challengingly, most other solid tumors, including ovarian carcinoma, are not particularly responsive to immunotherapy, so combination with a complementary therapy may be beneficial. Recent findings suggest that epigenetic modifying drugs can prime antitumor immunity by increasing expression of tumor-associated antigens, chemokines, and activating ligands by cancer cells as well as cytokines by immune cells. This review, drawing from both preclinical and clinical data, describes s... περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Abstract Recombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cells and K-562 human erythroblasts; this was accompanied with increased transport of the endogenous HSP70 to the plasma membrane. Important... περισσότερα »
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation
Abstract Targeting the tumor microenvironment focusing on immune cells has recently become a standard of care for some tumors. Indeed, antibodies blocking immune checkpoints (e.g., anti-CTLA-4 and anti-PD1 mAbs) have been approved by regulatory agencies for the treatment of some solid tumors based upon successes in many clinical trials. Although tumor metabolism has always attracted the attention of tumor biologists, only recently have oncologists renewed their interest in this field of tumor biology research. This has highlighted the possibility to pharmacologically target rate-li... περισσότερα »
Countering Staphylococcus Overgrowth During Patch Testing in Children with Moderate to Severe Atopic Dermatitis
Abstract Background Patients with moderate to severe atopic dermatitis (AD) often have a concurrent diagnosis of contact dermatitis, but patch testing in these patients presents a unique set of challenges. Barrier impairment and *Staphylococcus aureus* colonization and infection, along with the sealed occlusion that takes place during the patch testing procedure, can create an optimal environment for bacterial overgrowth. Aims To identify patients at risk for *S. aureus* overgrowth during patch testing and provide pre- and peripatch testing interventions to aid clinicians in obt... περισσότερα »
Linear Morphea Mimicking Lichen Striatus in Its Early Presentation
Abstract Linear morphea and lichen striatus are distinct conditions that have been linked in only one previous case report. We describe two patients with facial lichen striatus preceding linear morphea at the same site. A possible pathogenic relationship is discussed. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1NhjVk4 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1R8RoDj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qe1LWi v... περισσότερα »
Pillowcase Baby: A Laser Teaching Tool for Dermatology Residents
Abstract Laser therapy is an important treatment modality in pediatric dermatology, and its efficacy relies on the provider's proper use of the laser device. We describe a simple yet effective teaching tool that can be used to train dermatology residents prior to their using lasers on actual patients. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1NhjSF0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lNrZSA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on ...περισσότερα »
Low intratumoral regulatory T cells and high peritumoral CD8 + T cells relate to long-term survival in patients with pancreatic ductal adenocarcinoma after pancreatectomy
Abstract The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Recent studies have focused on the role of lymphocytes in the PDAC microenvironment. Using immunohistochemistry, our study explored the clinical significance of intratumoral or peritumoral CD4+Foxp3+ regulatory T cells (Tregs) and CD8+ T cells in the tumor microenvironment and analyzed their relation to the prognosis of PDAC in a consecutive series of 92 patients after resection. CD8+ T cells were more frequently seen within peritumoral sites, while CD4+Foxp3+ Tregs were more frequent within ...περισσότερα »
Low intratumoral regulatory T cells and high peritumoral CD8 + T cells relate to long-term survival in patients with pancreatic ductal adenocarcinoma after pancreatectomy
Abstract The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Recent studies have focused on the role of lymphocytes in the PDAC microenvironment. Using immunohistochemistry, our study explored the clinical significance of intratumoral or peritumoral CD4+Foxp3+ regulatory T cells (Tregs) and CD8+ T cells in the tumor microenvironment and analyzed their relation to the prognosis of PDAC in a consecutive series of 92 patients after resection. CD8+ T cells were more frequently seen within peritumoral sites, while CD4+Foxp3+ Tregs were more frequent within ...περισσότερα »
Improving cancer immunotherapy with DNA methyltransferase inhibitors
Abstract Immunotherapy confers durable clinical benefit to melanoma, lung, and kidney cancer patients. Challengingly, most other solid tumors, including ovarian carcinoma, are not particularly responsive to immunotherapy, so combination with a complementary therapy may be beneficial. Recent findings suggest that epigenetic modifying drugs can prime antitumor immunity by increasing expression of tumor-associated antigens, chemokines, and activating ligands by cancer cells as well as cytokines by immune cells. This review, drawing from both preclinical and clinical data, describes s... περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Abstract Recombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cells and K-562 human erythroblasts; this was accompanied with increased transport of the endogenous HSP70 to the plasma membrane. Important... περισσότερα »
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation
Abstract Targeting the tumor microenvironment focusing on immune cells has recently become a standard of care for some tumors. Indeed, antibodies blocking immune checkpoints (e.g., anti-CTLA-4 and anti-PD1 mAbs) have been approved by regulatory agencies for the treatment of some solid tumors based upon successes in many clinical trials. Although tumor metabolism has always attracted the attention of tumor biologists, only recently have oncologists renewed their interest in this field of tumor biology research. This has highlighted the possibility to pharmacologically target rate-li... περισσότερα »
Improving cancer immunotherapy with DNA methyltransferase inhibitors
Abstract Immunotherapy confers durable clinical benefit to melanoma, lung, and kidney cancer patients. Challengingly, most other solid tumors, including ovarian carcinoma, are not particularly responsive to immunotherapy, so combination with a complementary therapy may be beneficial. Recent findings suggest that epigenetic modifying drugs can prime antitumor immunity by increasing expression of tumor-associated antigens, chemokines, and activating ligands by cancer cells as well as cytokines by immune cells. This review, drawing from both preclinical and clinical data, describes s... περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Abstract Recombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cells and K-562 human erythroblasts; this was accompanied with increased transport of the endogenous HSP70 to the plasma membrane. Important... περισσότερα »
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation
Abstract Targeting the tumor microenvironment focusing on immune cells has recently become a standard of care for some tumors. Indeed, antibodies blocking immune checkpoints (e.g., anti-CTLA-4 and anti-PD1 mAbs) have been approved by regulatory agencies for the treatment of some solid tumors based upon successes in many clinical trials. Although tumor metabolism has always attracted the attention of tumor biologists, only recently have oncologists renewed their interest in this field of tumor biology research. This has highlighted the possibility to pharmacologically target rate-li... περισσότερα »
Low intratumoral regulatory T cells and high peritumoral CD8 + T cells relate to long-term survival in patients with pancreatic ductal adenocarcinoma after pancreatectomy
Abstract The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Recent studies have focused on the role of lymphocytes in the PDAC microenvironment. Using immunohistochemistry, our study explored the clinical significance of intratumoral or peritumoral CD4+Foxp3+ regulatory T cells (Tregs) and CD8+ T cells in the tumor microenvironment and analyzed their relation to the prognosis of PDAC in a consecutive series of 92 patients after resection. CD8+ T cells were more frequently seen within peritumoral sites, while CD4+Foxp3+ Tregs were more frequent within ...περισσότερα »
Improving cancer immunotherapy with DNA methyltransferase inhibitors
Abstract Immunotherapy confers durable clinical benefit to melanoma, lung, and kidney cancer patients. Challengingly, most other solid tumors, including ovarian carcinoma, are not particularly responsive to immunotherapy, so combination with a complementary therapy may be beneficial. Recent findings suggest that epigenetic modifying drugs can prime antitumor immunity by increasing expression of tumor-associated antigens, chemokines, and activating ligands by cancer cells as well as cytokines by immune cells. This review, drawing from both preclinical and clinical data, describes s... περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Abstract Recombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cells and K-562 human erythroblasts; this was accompanied with increased transport of the endogenous HSP70 to the plasma membrane. Important... περισσότερα »
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation
Abstract Targeting the tumor microenvironment focusing on immune cells has recently become a standard of care for some tumors. Indeed, antibodies blocking immune checkpoints (e.g., anti-CTLA-4 and anti-PD1 mAbs) have been approved by regulatory agencies for the treatment of some solid tumors based upon successes in many clinical trials. Although tumor metabolism has always attracted the attention of tumor biologists, only recently have oncologists renewed their interest in this field of tumor biology research. This has highlighted the possibility to pharmacologically target rate-li... περισσότερα »
Countering Staphylococcus Overgrowth During Patch Testing in Children with Moderate to Severe Atopic Dermatitis
Abstract Background Patients with moderate to severe atopic dermatitis (AD) often have a concurrent diagnosis of contact dermatitis, but patch testing in these patients presents a unique set of challenges. Barrier impairment and *Staphylococcus aureus* colonization and infection, along with the sealed occlusion that takes place during the patch testing procedure, can create an optimal environment for bacterial overgrowth. Aims To identify patients at risk for *S. aureus* overgrowth during patch testing and provide pre- and peripatch testing interventions to aid clinicians in obt... περισσότερα »
Linear Morphea Mimicking Lichen Striatus in Its Early Presentation
Abstract Linear morphea and lichen striatus are distinct conditions that have been linked in only one previous case report. We describe two patients with facial lichen striatus preceding linear morphea at the same site. A possible pathogenic relationship is discussed. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1NhjVk4 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1R8RoDj via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Qe1LWi v... περισσότερα »
Pillowcase Baby: A Laser Teaching Tool for Dermatology Residents
Abstract Laser therapy is an important treatment modality in pediatric dermatology, and its efficacy relies on the provider's proper use of the laser device. We describe a simple yet effective teaching tool that can be used to train dermatology residents prior to their using lasers on actual patients. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1NhjSF0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lNrZSA via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on ...περισσότερα »
Low intratumoral regulatory T cells and high peritumoral CD8 + T cells relate to long-term survival in patients with pancreatic ductal adenocarcinoma after pancreatectomy
Abstract The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Recent studies have focused on the role of lymphocytes in the PDAC microenvironment. Using immunohistochemistry, our study explored the clinical significance of intratumoral or peritumoral CD4+Foxp3+ regulatory T cells (Tregs) and CD8+ T cells in the tumor microenvironment and analyzed their relation to the prognosis of PDAC in a consecutive series of 92 patients after resection. CD8+ T cells were more frequently seen within peritumoral sites, while CD4+Foxp3+ Tregs were more frequent within ...περισσότερα »
Low intratumoral regulatory T cells and high peritumoral CD8 + T cells relate to long-term survival in patients with pancreatic ductal adenocarcinoma after pancreatectomy
Abstract The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Recent studies have focused on the role of lymphocytes in the PDAC microenvironment. Using immunohistochemistry, our study explored the clinical significance of intratumoral or peritumoral CD4+Foxp3+ regulatory T cells (Tregs) and CD8+ T cells in the tumor microenvironment and analyzed their relation to the prognosis of PDAC in a consecutive series of 92 patients after resection. CD8+ T cells were more frequently seen within peritumoral sites, while CD4+Foxp3+ Tregs were more frequent within ...περισσότερα »
Improving cancer immunotherapy with DNA methyltransferase inhibitors
Abstract Immunotherapy confers durable clinical benefit to melanoma, lung, and kidney cancer patients. Challengingly, most other solid tumors, including ovarian carcinoma, are not particularly responsive to immunotherapy, so combination with a complementary therapy may be beneficial. Recent findings suggest that epigenetic modifying drugs can prime antitumor immunity by increasing expression of tumor-associated antigens, chemokines, and activating ligands by cancer cells as well as cytokines by immune cells. This review, drawing from both preclinical and clinical data, describes s... περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Abstract Recombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cells and K-562 human erythroblasts; this was accompanied with increased transport of the endogenous HSP70 to the plasma membrane. Important... περισσότερα »
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation
Abstract Targeting the tumor microenvironment focusing on immune cells has recently become a standard of care for some tumors. Indeed, antibodies blocking immune checkpoints (e.g., anti-CTLA-4 and anti-PD1 mAbs) have been approved by regulatory agencies for the treatment of some solid tumors based upon successes in many clinical trials. Although tumor metabolism has always attracted the attention of tumor biologists, only recently have oncologists renewed their interest in this field of tumor biology research. This has highlighted the possibility to pharmacologically target rate-li... περισσότερα »
Improving cancer immunotherapy with DNA methyltransferase inhibitors
Abstract Immunotherapy confers durable clinical benefit to melanoma, lung, and kidney cancer patients. Challengingly, most other solid tumors, including ovarian carcinoma, are not particularly responsive to immunotherapy, so combination with a complementary therapy may be beneficial. Recent findings suggest that epigenetic modifying drugs can prime antitumor immunity by increasing expression of tumor-associated antigens, chemokines, and activating ligands by cancer cells as well as cytokines by immune cells. This review, drawing from both preclinical and clinical data, describes s... περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Abstract Recombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cells and K-562 human erythroblasts; this was accompanied with increased transport of the endogenous HSP70 to the plasma membrane. Important... περισσότερα »
Cholesterol metabolites and tumor microenvironment: the road towards clinical translation
Abstract Targeting the tumor microenvironment focusing on immune cells has recently become a standard of care for some tumors. Indeed, antibodies blocking immune checkpoints (e.g., anti-CTLA-4 and anti-PD1 mAbs) have been approved by regulatory agencies for the treatment of some solid tumors based upon successes in many clinical trials. Although tumor metabolism has always attracted the attention of tumor biologists, only recently have oncologists renewed their interest in this field of tumor biology research. This has highlighted the possibility to pharmacologically target rate-li... περισσότερα »
Low intratumoral regulatory T cells and high peritumoral CD8 + T cells relate to long-term survival in patients with pancreatic ductal adenocarcinoma after pancreatectomy
Abstract The prognosis for pancreatic ductal adenocarcinoma (PDAC) remains extremely poor. Recent studies have focused on the role of lymphocytes in the PDAC microenvironment. Using immunohistochemistry, our study explored the clinical significance of intratumoral or peritumoral CD4+Foxp3+ regulatory T cells (Tregs) and CD8+ T cells in the tumor microenvironment and analyzed their relation to the prognosis of PDAC in a consecutive series of 92 patients after resection. CD8+ T cells were more frequently seen within peritumoral sites, while CD4+Foxp3+ Tregs were more frequent within ...περισσότερα »
Improving cancer immunotherapy with DNA methyltransferase inhibitors
Abstract Immunotherapy confers durable clinical benefit to melanoma, lung, and kidney cancer patients. Challengingly, most other solid tumors, including ovarian carcinoma, are not particularly responsive to immunotherapy, so combination with a complementary therapy may be beneficial. Recent findings suggest that epigenetic modifying drugs can prime antitumor immunity by increasing expression of tumor-associated antigens, chemokines, and activating ligands by cancer cells as well as cytokines by immune cells. This review, drawing from both preclinical and clinical data, describes s... περισσότερα »
Phloretin increases the anti-tumor efficacy of intratumorally delivered heat-shock protein 70 kDa (HSP70) in a murine model of melanoma
Abstract Recombinant HSP70 chaperone exerts a profound anticancer effect when administered intratumorally. This action is based on the ability of HSP70 to penetrate tumor cells and extract its endogenous homolog. To enhance the efficacy of HSP70 cycling, we employed phloretin, a flavonoid that enhances the pore-forming activity of the chaperone on artificial membranes. Phloretin increased the efficacy of HSP70 penetration in B16 mouse melanoma cells and K-562 human erythroblasts; this was accompanied with increased transport of the endogenous HSP70 to the plasma membrane. Important... περισσότερα »
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