Head and Neck Medicine by Alexandros G.Sfakianakis: OtoRhinoLaryngology & Medicine,New Articles,January 22nd,2016

Παρασκευή 22 Ιανουαρίου 2016

OtoRhinoLaryngology & Medicine,New Articles,January 22nd,2016

Robot-Assisted Stereoelectroencephalography

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 λεπτό

Technique, Results, and Complications Related to Robot-Assisted Stereoelectroencephalography: BACKGROUND: Robot-assisted stereoelectroencephalography (SEEG) may represent a simplified, precise, and safe alternative to the more traditional SEEG techniques. OBJECTIVE: To report our clinical experience with robotic SEEG implantation and to define its utility in the management of patients with medically refractory epilepsy. METHODS: The prospective observational analyses included all patients with medically refractory focal epilepsy who underwent robot-assisted stereotactic placement of ...περισσότερα »

Delayed Facial Palsy After Vestibular Schwannoma Resection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Incidence and Risk Factors of Delayed Facial Palsy After Vestibular Schwannoma Resection: BACKGROUND: Preservation of facial nerve function following vestibular schwannoma surgery is a high priority. Even those patients with normal to near-normal function in the early postoperative period remain at risk for delayed facial palsy (DFP). OBJECTIVE: To evaluate the incidence and prognosis of DFP and to identify risk factors for its occurrence. METHODS: A retrospective cohort study of 489 patients who underwent vestibular schwannoma resection at our institution between 2000 and 2014. Dela...περισσότερα »

Lymphatics in the Brain?!

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 2 δευτερόλεπτα

Lymphatics in the Brain?!: That the brain lacks lymphatic drainage is a well-established dogma and an early lesson for medical students and residents. Although robust lymphatics in the central nervous system are indeed lacking, elements of neuroanatomy remain open to refinement. Indeed, 2 excellent publications by Aspelund et al1 and Louveau et al2 recently reported the existence of lymphatic structures in the brain, subsequently labeled the brain drain.3 Although descriptions of a lymphatic system in the brain have previously been reported, these studies were not intensively di... περισσότερα »

Parental support has positive effect on children’s eating behaviours

fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα

Drivers of Dashboard Development (3-D): A Curricular Continuous Quality Improvement Approach.

Problem: Undergraduate medical education (UME) programs are seeking systematic ways to monitor and manage their educational performance metrics and document their achievement of external goals (e.g., Liaison Committee on Medical Education [LCME] accreditation requirements) and internal objectives (institution-specific metrics). In other continuous quality improvement (CQI) settings, summary dashboard reports have been used to evaluate and […]

MRT verbessert nicht die Demenzvorhersage

Kritisch gelesen Das Ergebnis des MRT-Befundes verbessert die mögliche Früherkennung einer Demenz im Vergleich zu klinischen Risikofaktoren nicht, wie eine Studie belegt. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1OBbS4l via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1RY0IuO via […]

An Innovative Blended Preclinical Curriculum in Clinical Epidemiology and Biostatistics: Impact on Student Satisfaction and Performance.

Problem: There is little understanding of the impact of teaching clinical epidemiology and biostatistics in a flipped or blended format. At Stanford University School of Medicine, the quantitative medicine (QM) curriculum for first-year students was redesigned to use a blended format, in response to student feedback. Approach: The blended QM curriculum introduced in 2013 integrated […]

Psoriasis, Exanthem oder Karzinom?

Hartnäckiger, geröteter Herd am Genitale Bei einem 56-jährigen, ansonsten gesunden Mann besteht seit Jahren ein unregelmäßig konfigurierter, geröteter, gering erosiver Herd an der Glans penis und dem angrenzenden inneren Präputialraum. Subjektive Beschwerden hat der Patient nicht. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RXWPpR via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & […]

Is There a Consensus on Consensus Methodology? Descriptions and Recommendations for Future Consensus Research.

The authors of this article reviewed the methodology of three common consensus methods: nominal group process, consensus development panels, and the Delphi technique. The authors set out to determine how a majority of researchers are conducting these studies, how they are analyzing results, and subsequently the manner in which they are reporting their findings. The […]

Autophagy-related gene 5 and Wnt5 signaling pathway requires differentiation of embryonic stem cells into odontoblast-like cells

Publication date: Available online 21 January 2016 Source:Experimental Cell Research Author(s): Nobuaki Ozeki, Makio Mogi, Naoko Hase, Taiki Hiyama, Hideyuki Yamaguchi, Rie Kawai, Ayami Kondo, Toru Matsumoto, Kazuhiko Nakata We previously confirmed a unique and unanticipated role for an α2 integrin, extracellular matrix metalloproteinase inducer (Emmprin), and matrix metalloproteinase (MMP)-3-mediated signaling cascade, in driving the […]

Tools to Assess Behavioral and Social Science Competencies in Medical Education: A Systematic Review.

Purpose: Behavioral and social science (BSS) competencies are needed to provide quality health care, but psychometrically validated measures to assess these competencies are difficult to find. Moreover, they have not been mapped to existing frameworks, like those from the Liaison Committee on Medical Education (LCME) and Accreditation Council for Graduate Medical Education (ACGME). This systematic […]

99mTc-anti-TNF-{alpha} antibody for the imaging of disease activity in pulmonary sarcoidosis

Infliximab, a monoclonal antibody directed against tumour necrosis factor (TNF)-α, is used in the treatment of refractory sarcoidosis. However, the clinical response is variable and a tool to select responders beforehand is highly desirable. In this study we evaluated scintigraphy with technetium-99m (99mTc)-labelled infliximab for the imaging of disease activity in patients with pulmonary sarcoidosis. […]

Giving Context to the Physician Competency Reference Set: Adapting to the Needs of Diverse Populations.

Delineating the requisite competencies of a 21st-century physician is the first step in the paradigm shift to competency-based medical education. Over the past two decades, more than 150 lists of competencies have emerged. In a synthesis of these lists, the Physician Competency Reference Set (PCRS) provided a unifying framework of competencies that define the general […]

Spontaneous Improvement of Chiari I Malformation and Syringomyelia in a Patient With Cystic Fibrosis: Case Report

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Spontaneous Improvement of Chiari I Malformation and Syringomyelia in a Patient With Cystic Fibrosis: Case Report: [image: image]BACKGROUND AND IMPORTANCE: Syringomyelia is highly associated with Chiari I malformation, but the pathophysiologic mechanism of syrinx formation and its relation to downward cerebellar tonsillar displacement remains elusive. Cough, Valsalva maneuver, and other physiological strains transiently exacerbate the clinical symptoms of these conditions, exert profound effects on the flow dynamics across the craniospinal junction, and are thought to play an import...περισσότερα »

Identifying and Managing Local Anesthetic Allergy in Dermatologic Surgery.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα

Identifying and Managing Local Anesthetic Allergy in Dermatologic Surgery.: BACKGROUND: Local anesthetic (LA) allergy is a concern for dermatologic surgeons given the large number of procedures performed yearly with LAs. Many patients also have anxiety about past or potential anesthesia allergy. OBJECTIVE: This article will review the symptoms of IgE-mediated allergic reactions, the prevalence of IgE-mediated LA allergy, discuss common mimics of LA, and propose a practical approach for diagnostic and therapeutic options for LA allergy for the dermatologic surgeon in practice. MATERIAL...περισσότερα »

These new articles for The Journal of Clinical Endocrinology & Metabolism are available online

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 4 δευτερόλεπτα

These new articles for The Journal of Clinical Endocrinology & Metabolism are available online ------------------------------ Early Release The Journal of Clinical Endocrinology & Metabolism ------------------------------ [image: Journal of Clinical Endocrinology & Metabolism masthead] ------------------------------ ------------------------------ The Journal of Clinical Endocrinology & Metabolism Home Page Current Issue Past Issues ------------------------------ ------------------------------ ------------------------------ ------------------------------ Impact of long-term poor and ... περισσότερα »

Angiolymphoid hyperplasia with eosinophilia in parotid gland

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 8 δευτερόλεπτα

Angiolymphoid hyperplasia with eosinophilia in parotid gland: A diagnostic challenge: *Bifica Sofia Lyngdoh, Anadi Roy Chowdhury, Soumya Ghatak, Gautam Bandyopadhyay* Archives of International Surgery 2015 5(4):217-219 Angiolymphoid hyperplasia with eosinophilia (ALHE) rarely involves the parotid glands or other major glands. ALHE and Kimura's disease (KD) share many clinical and histopathological features. Ill-defined, deeply seated lesions involving the parotid glands are frequently observed in KD, and only three cases of intraparotid ALHE have been reported in the literature.... περισσότερα »

The pure tone audiogram assessment

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα

The pure tone audiogram assessment of the students of a special school for deaf in Kaduna: *Iliyasu Yunusa Shuaibu, Aminu Bakari, Abdulazeez Ahmed, Mohammed Aminu Usman* Archives of International Surgery 2015 5(4):206-209 Background: Hearing impairment in children is an important public health problem. Children with hearing impairment are educated in special schools (schools for the deaf) and in our locality all are assumed to be deaf without necessarily subjecting them to audiological evaluation in some cases. The objective of this study was to identify the cause of hearing im... περισσότερα »

Focal Cingulum Injury by Minor and Direct Head Trauma: A Diffusion Tensor Tractography Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Focal Cingulum Injury by Minor and Direct Head Trauma: A Diffusion Tensor Tractography Study: [image: image]

Evaluation of a smartphone human activity recognition application

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα

Evaluation of a smartphone human activity recognition application with able-bodied and stroke participants: Mobile health monitoring using wearable sensors is a growing area of interest. As the world’s population ages and locomotor capabilities decrease, the ability to report on a person’s mobility activities outsid...

Toxoplasmosis Encephalitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Presentation and Rehabilitation In A Patient With Toxoplasmosis Encephalitis: A Case Study and Review: Toxoplasma gondii is an opportunistic infection that often presents in the setting of acquired immunodeficiency syndrome (AIDS). The infection can cause severe and potentially fatal encephalitis due to the reactivation of latent infections in the setting of immune suppression. Diagnosing toxoplasmosis encephalitis in immunocompromised patients is often difficult because the signs and symptoms can be non-specific, but making a diagnosis of TE is even more challenging in a patient wh...περισσότερα »

Endovascular Treatment of Stroke, Oral Anticoagulant–associated Intracerebral Hemorrhage, and Treatment of Extracranial Dissection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα

Endovascular Treatment of Stroke, Oral Anticoagulant–associated Intracerebral Hemorrhage, and Treatment of Extracranial Dissection: [image: rccm.201506-1152rr.fp.png_v03] American Journal of Respiratory and Critical Care Medicine, Volume 193, Issue 2, Page 210-212, January 15, 2016.

The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

The Impact of Obstructive Sleep Apnea and Tobacco Smoking on Endothelial Function: *Background:* Endothelial dysfunction has been recognized to occur in the context of obstructive sleep apnea (OSA) or tobacco smoking. However, the deleterious effect on vascular function with concurrence of both conditions is largely unknown. *Objective:* To investigate whether the concurrence of OSA and smoking poses an additive detriment to endothelial dysfunction. *Methods:* Chinese men without a history of chronic medical illness were invited to complete a questionnaire including smoking pack-yea...περισσότερα »

Hemoptysis in Leukocytoclastic Vasculitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα

An Unusual Spectacle of Hemoptysis in Leukocytoclastic Vasculitis: [image: image]

Melatonin attenuated adipogenesis through reduction of the CCAAT/enhancer binding protein beta by regulating the glycogen synthase 3 beta in human mesenchymal stem cells

Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 17 δευτερόλεπτα

Abstract Adipogenic differentiation is characterized by an increase in two major transcription factors: peroxisome proliferator-activated receptor gamma (PPARγ) and the CCAAT/enhancer binding protein alpha (C/EBPα). These two signals are influenced by C/EBPβ and C/EBPδ and cross-regulate each other's expression during the initial stages of adipogenesis. Melatonin has been known to act as not only a direct scavenger of free radicals but also an inhibitor of glycogen synthase kinase 3β (GSK-3β). Here, we report that melatonin inhibits the adipogenic differentiation of human mesenchym...περισσότερα »

Diseases, Vol. 4, Pages 6: Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

Colorectal cancer is one of the main causes of cancer-related mortality in the developed world. Carcinogenesis is a multistage process conventionally defined by the initiation, promotion and progression stages. Natural polyphenolic compounds can act as highly effective antioxidant and chemo-preventive agents able to interfere at the three stages of cancer. Cocoa has been demonstrated to counteract oxidative stress and to have a potential capacity to interact with multiple carcinogenic pathways involved in inflammation, proliferation and apoptosis of initiated and malignant cells. ...περισσότερα »

Surface activation of CNT Webs towards layer by layer assembly of Biosensors

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα

[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02547H, Paper Mustafa M Musameh, Chi Huynh, Mark Hicky, Ilias Louis Kyratzis Several surface activation methods such as chemical, electrochemical and plasma have been used for enhancing the electrochemical performance of carbon based electrodes for various applications. However, some of these surface... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1nCohw9 via IFTTT

Surface activation of CNT Webs towards layer by layer assembly of Biosensors

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 δευτερόλεπτα

Parental support has positive effect on children’s eating behaviours

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 22 δευτερόλεπτα

Parental support programmes in areas with the greatest needs can have a positive effect on the consumption of unhealthy food and drink and on weight increases in obese children. This according to a randomised study conducted by Karolinska Institutet and the Stockholm County Council published in the International Journal of Behavioural Nutrition and Physical Activity. Even though school-based programmes promoting healthy eating and physical activity and preventing overweight have had a demonstrable effect, more knowledge is needed on how to best involve the children's parents. The ...περισσότερα »

Percutaneous Dilatational Tracheostomy With Direct Bronchoscopic Guidance for Thoracic Transplant Recipients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα

Safety and Efficiency of Percutaneous Dilatational Tracheostomy With Direct Bronchoscopic Guidance for Thoracic Transplant Recipients: BACKGROUND:Percutaneous dilatational tracheostomy (PDT) is the standard airway access in critically ill patients who require prolonged mechanical ventilation. However, the literature lacks reports about the effectiveness and safety of this procedure in thoracic organ transplant recipients, who have increased risks of bleeding and infection.METHODS:We retrospectively reviewed the records of subjects who underwent thoracic organ transplantation at our ... περισσότερα »

Traffic-related air pollution and alveolar nitric oxide in southern California children

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα

Mechanisms for the adverse respiratory effects of traffic-related air pollution (TRAP) have yet to be established. We evaluated the acute effects of TRAP exposure on proximal and distal airway inflammation by relating indoor nitric oxide (NO), a marker of TRAP exposure in the indoor microenvironment, to airway and alveolar sources of exhaled nitric oxide (FeNO). […]

Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα

The effects of pneumococcal conjugated vaccines (PCVs) need to be investigated. In Stockholm County, Sweden, PCV7 was introduced in the childhood immunisation programme in 2007 and changed to PCV13 in 2010. Over 90% of all invasive isolates during 2005–2014 (n=2336) and carriage isolates, 260 before and 647 after vaccine introduction, were characterised by serotyping, molecular […]

Outcome of patients with right heart thrombi: the Right Heart Thrombi European Registry

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα

Our aim was the assessment of the prognostic significance of right heart thrombi (RiHT) and their characteristics in pulmonary embolism in relation to established prognostic factors. 138 patients (69 females) aged (mean±sd) 62±19 years with RiHT were included into a multicenter registry. A control group of 276 patients without RiHT was created by propensity scoring […]

Characterization of high risk melanoma patients in Austria

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 32 δευτερόλεπτα

Summary Background Risk of melanoma is determined by genetic and exogenous factors. Only a few studies included both characteristics in a comprehensive multivariable analysis. Objective To find determinants of high risk melanoma patients in Austria, including phenotype, genotype and lifestyle characteristics in comprehensive analyses. Methods: 1668 melanoma patients from the M3 case-control study were studied. […]

Calculation of cut-off values based on the ABSIS and PDAI pemphigus scoring systems for defining moderate, significant and extensive types of pemphigus

Abstract Background Two pemphigus severity scores, Autoimmune-Bullous-Skin-Disorder-Intensity-Score (ABSIS) and Pemphigus-Disease-Area-Index (PDAI), have been proposed to provide an objective measure of disease activity. However, the use of these scores in clinical practice is limited by the absence of cut-off values which allow differentiation between moderate, significant and extensive types of pemphigus. Objective To calculate cut-off values […]

A Randomized Phase 2b Trial of Baricitinib, an Oral JAK1/JAK2 Inhibitor, in Patients with Moderate-to-Severe Psoriasis

Oral alitretinoin treatment in patients with palmoplantar pustulosis inadequately responding to standard topical treatment: a randomised Phase II study

Diagnostic challenges in the work up of hypereosinophilia: pitfalls in bone marrow core biopsy interpretation

Abstract The FIP1L1-PDGFRA (FP) fusion gene is identified in a substantial proportion of patients with eosinophilia-associated myeloproliferative neoplasms (MPN-eo) who subsequently achieve rapid and durable remissions on imatinib. In the initial diagnostic work-up of hypereosinophilia (HE), histologic and immunohistochemical evaluation of a bone marrow (BM) core biopsy is considered essential for the differentiation between reactive […]

Serum midkine as a biomarker for malignancy, prognosis, and chemosensitivity in head and neck squamous cell carcinoma

Thyrotropin-secreting pituitary adenomas: epidemiology, diagnosis, and management

Abstract Inappropriate secretion of TSH was first described in 1960 in a patient with evidence of hyperthyroidism and expanded sella on imaging. It was later found that a type of pituitary adenoma that secretes TSH (thyrotropinoma) was the underlying cause. The objective of the present review article is to summarize data on the epidemiology, pathogenesis, […]

Calculation of cut-off values based on the ABSIS and PDAI pemphigus scoring systems for defining moderate, significant and extensive types of pemphigus

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 33 δευτερόλεπτα

A Randomized Phase 2b Trial of Baricitinib, an Oral JAK1/JAK2 Inhibitor, in Patients with Moderate-to-Severe Psoriasis

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 33 δευτερόλεπτα

Abstract Background The safety and efficacy of baricitinib, an oral JAK1/JAK2 inhibitor, in patients with moderate-to-severe psoriasis was evaluated in a randomized, double-blind, placebo-controlled, dose-ranging phase 2b study. Methods Patients were randomized (n=271) to receive placebo or oral baricitinib at 2, 4, 8, or 10 mg once daily for 12 weeks (Part A). Dose adjustment for 12 additional weeks was based on percentage improvement in Psoriasis Area and Severity Index (PASI) score. Objectives Primary endpoint was PASI-75 at 12 weeks for North American patients (n=238); seco... περισσότερα »

Oral alitretinoin treatment in patients with palmoplantar pustulosis inadequately responding to standard topical treatment: a randomised Phase II study

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 33 δευτερόλεπτα

Abstract Background Palmoplantar pustulosis (PPP) is an inflammatory, debilitating skin disease. Topical drugs and systemic immunosuppressive agents are often ineffective. Previous uncontrolled studies have suggested that alitretinoin could be a meaningful treatment option for PPP. Objectives The primary objective of the study was to determine response to alitretinoin for the treatment of PPP based on the palmoplantar pustulosis area and severity index (PPPASI) after 24 weeks of treatment. Methods Phase II, randomised, double-blind, placebo-controlled, multicentre study. Adult ... περισσότερα »

Early tissue reaction in the tension zone of PDL during orthodontic tooth movement

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 34 δευτερόλεπτα

Publication date: Available online 21 January 2016 *Source:*Archives of Oral Biology Author(s): A. Tsuge, K. Noda, Y. Nakamura ObjectiveThe aim of the study was to examine the early tissue reaction in the tension zone of periodontal ligament (PDL) during orthodontic tooth movement.DesignUpper first molars of rats were moved buccally with fixed appliances. The PDL in the tension zone was examined histologically, immunohistochemically and at a molecular level after 24hours, 3days and 7 days.ResultsAfter 24hours of orthodontic force loading, the periodontal space appeared considerably ... περισσότερα »

Use of Radiation Therapy in Locally Advanced Pancreatic Cancer Improves Survival: A SEER Database Analysis.

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 35 δευτερόλεπτα

Objectives: Although both radiation therapy and chemotherapy are frequently used to treat locally advanced pancreatic cancer (LAPC) patients, the role of radiation therapy remains controversial with data evaluating its efficacy mostly derived from small randomized trials. In this study, we evaluate the survival benefit of radiation therapy using SEER dataset in patients with LAPC. Materials and Methods: The SEER Registry dataset from 2004 to 2011 was queried to identify LAPC (TNM stage III) patients. Patients with survival from Cancer via ola Kala on Inoreader http://ift.tt/1ZGd0XA ... περισσότερα »

PAX2, PAX8 and CDX2 Expression in Metastatic Mucinous, Primary Ovarian Mucinous and Seromucinous Tumors and Review of the Literature

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 35 δευτερόλεπτα

Abstract Ovarian cancer is the most common cause of gynecologic cancer death. Both morphologically and immunohistochemically, metastatic mucinous tumors are the best mimickers of mucinous ovarian tumors; its pathogenesis still remains a mystery. PAX2 and PAX8 immunohisyochemistries are useful for differentiating numerous primary tumour types from metastatic ones. There are few studies in literature about PAX expressions in mucinous and seromucinous tumors. None of these are takes into account the histologic type (whether it is seromucinous or mucinous) or the metastatic origin. Wi... περισσότερα »

Comparison of Sagittal FSE T2, STIR, and T1-Weighted Phase-Sensitive Inversion Recovery in the Detection of Spinal Cord Lesions in MS at 3T [SPINE]

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 40 δευτερόλεπτα

BACKGROUND AND PURPOSE: Determining the diagnostic accuracy of different MR sequences is essential to design MR imaging protocols. The purpose of the study was to compare 3T sagittal FSE T2, STIR, and T1-weighted phase-sensitive inversion recovery in the detection of spinal cord lesions in patients with suspected or definite MS. MATERIALS AND METHODS: We performed a retrospective analysis of 38 patients with suspected or definite MS. Involvement of the cervical and thoracic cord segments was recorded on sagittal FSE T2, STIR, and T1-weighted phase-sensitive inversion recovery s...περισσότερα »

Smoking Does Not Affect Occlusion Rates and Morbidity-Mortality after Pipeline Embolization for Intracranial Aneurysms [INTERVENTIONAL]

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 40 δευτερόλεπτα

BACKGROUND AND PURPOSE: Smoking is a major risk factor for patients with intracranial aneurysms, yet the effects of smoking on outcomes of aneurysm with flow-diverter treatment remain unknown. We studied the impact of smoking on long-term angiographic and clinical outcomes after flow-diverter treatment of intracranial aneurysms. MATERIALS AND METHODS: We retrospectively reviewed data from patients treated with the Pipeline Embolization Device and included in the International Retrospective Study of the Pipeline Embolization Device, the Pipeline for Uncoilable or Failed Aneurysm...περισσότερα »

Management of Sleep Disorders in Children With Neurodevelopmental Disorders: A Review

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Management of Sleep Disorders in Children With Neurodevelopmental Disorders: A Review: Neurodevelopmental disorders (NDDs) are defined as a group of disorders caused by changes in early brain development, resulting in behavioral and cognitive alterations in sensory and motor systems, speech, and language. NDDs affect approximately 1–2% of the general population. Up to 80% of children with NDDs are reported to have disrupted sleep; subsequent deleterious effects on daytime behaviors, cognition, growth, and overall development of the child are commonly reported. Examples of NDDs disc... περισσότερα »

Same strategy for pitfalls of radiotherapy in different anatomical districts

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract Oral mucositis (OM) and radiodermatitis (RD) are serious side effects of radiotherapy (RT), often leading to its suspension, need for analgesics, and enteral/parenteral nutrition. Laser therapy is becoming a recommended treatment option. This prospective study aimed at demonstrating the beneficial effect of class IV laser therapy (HPLT) on RT-induced OM, an off-label use of HPLT to treat RD in breast cancer patients. Fifty-three cancer patients, during/after RT and/or chemotherapy (CT), affected by OM, were treated with HPLT during four consecutive days (970 ± 15 nm, 5 W ...περισσότερα »

A novel approach for in-office tooth bleaching with 6 % H 2 O 2 /TiO_N and LED/laser system—a controlled, triple-blinded, randomized clinical trial

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract The purpose of this randomized, parallel, triple-blinded clinical trial was to compare efficacy and tooth sensitivity (TS) after use of an in-office bleaching agent of 6 % hydrogen peroxide containing nanoparticles of nitrogen-doped titanium oxide (HP6) vs. 35 % hydrogen peroxide (HP35). Forty-eight volunteers were randomly divided either a HP6 or HP35. Two clinical sessions were performed with an interval of 7 days between them for each group. In each session, two consecutive applications of each bleaching agent were performed and activated by a hybrid LED/laser light. E... περισσότερα »

Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract Clinical experiences with non-ablative fractional erbium glass laser therapy have demonstrated promising results for dermal remodelling and for the indications of striae, surgical scars and acne scars. So far, molecular effects on human skin following treatment with these laser systems have not been elucidated. Our aim was to investigate laser-induced effects on skin morphology and to analyse molecular effects on gene regulation. Therefore, human three-dimensional (3D) organotypic skin models were irradiated with non-ablative fractional erbium glass laser systems enabling ... περισσότερα »

The long-term effect of 1550 nm erbium:glass fractional laser in acne vulgaris

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract We evaluated the short-term and long-term effects of the 1550 nm erbium:glass (Er:glass) fractional laser in the treatment of facial acne vulgaris. Forty-five (9 male and 36 female) acne patients were treated 4 times at 4-week intervals with the following parameters: 169 spot density and 15–30 mJ/cm2 fluence. There was no control group. The laser spots were adjustable (maximum overlap: 20 %) according to the treatment area, and delivered in rows in order to cover all the face. Clinical photographs were taken. The IGA scores and lesion counts were performed for each treatme... περισσότερα »

Evaluation of different laser wavelengths on ablation lesion and residual thermal injury in intervertebral discs of the lumbar spine

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract Laser discectomy or nucleotomy is an increasingly important method for less invasive procedures of column, but the ideal kind of laser is still not established. As the wavelength is an important parameter for water absorption, this study was performed to investigate the action of the laser emission in the near infrared (808 to 1908 nm) region in the context of surgical procedures for percutaneous intervertebral disc decompression (nucleotomy). Forty intervertebral discs from pigs lumbar spines were irradiated with laser (*λ* = 808, 980, 1470 and 1908 nm), 1-s on/off time ... περισσότερα »

Sustained effects of blue light on Streptococcus mutans in regrown biofilm

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract In prior studies, exposure of *Streptococcus mutans* in biofilm to blue light using high fluences of up to 680 J/cm2 did not interfere with bacterial capability to reform an initial biofilm; however, a delayed antibacterial effect was observed. Our aim was to determine the sustained effecttts of blue light-emitting diode (LED) curing light on the pathogenicity of the newly formed biofilm. *S. mutans* were grown to form biofilm that was exposed to blue light (wavelengths, 460–480 nm) for 1, 3, and 7 min (equivalent to 37, 112, and 262 J/cm2, respectively). Then, bacteria w... περισσότερα »

Low-intensity red and infrared lasers affect mRNA expression of DNA nucleotide excision repair in skin and muscle tissue

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract Lasers emit light beams with specific characteristics, in which wavelength, frequency, power, fluence, and emission mode properties determine the photophysical, photochemical, and photobiological responses. Low-intensity lasers could induce free radical generation in biological tissues and cause alterations in macromolecules, such as DNA. Thus, the aim of this work was to evaluate excision repair cross-complementing group 1 (ERCC1) and excision repair cross-complementing group 2 (ERCC2) messenger RNA (mRNA) expression in biological tissues exposed to low-intensity lasers. ... περισσότερα »

LLLT for the management of patients with ankylosing spondylitis

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract This study aimed to compare the effectiveness of the combined low-level laser therapy (LLLT) and passive stretching with combined placebo LLLT laser and the same passive stretching exercises in patients suffering from Αnkylosing spondylitis. Forty-eight patients suffering from Αnkylosing spondylitis participated in the study and were randomized into two groups. Group A (*n* = 24) was treated with a *λ* = 820 Ga-Al-As laser CW, with power intensity = 60 mW/cm2, energy per point in each session = 4.5 J, total energy per session = 27.0 J, in contact with specific points tech...περισσότερα »

Mitochondrial dependent oxidative stress in cell culture induced by laser radiation at 1265 nm

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 40 δευτερόλεπτα

Abstract Photodynamic therapy is the main technique applied for surface carcinoma treatment. This technique employs singlet oxygen generated via a laser excited photosensitizer as a main damaging agent. However, prolonged sensitivity to intensive light, relatively low tissue penetration by activating light the cost of photosensitizer (PS) administration can limit photodynamic therapy applications. Early was reported singlet oxygen generation without photosensitizer induced by a laser irradiation at the wavelength of 1250–1270 nm. Here, we study the dynamics of oxidative stress, DN... περισσότερα »

Autophagy-related gene 5 and Wnt5 signaling pathway requires differentiation of embryonic stem cells into odontoblast-like cells

Study Finds Beedi Smoking Is a Risk Factor for Gastric Cancer – India West

India West Study Finds Beedi Smoking Is a Risk Factor for Gastric Cancer India West THIRUVANANTHAPURAM — Beedi, which has been known for a long time to be a source of cancers of the lung and oral cavity, is also a causative risk factor for gastric malignancy, says a study by the Regional Cancer Centre […]

Identification of Suitable Endogenous Normalizers for qRT-PCR Analysis of Plasma microRNA Expression in Essential Hypertension

Abstract Circulating microRNAs (miRNAs) are promising biomarkers for many diseases. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) is a gold standard for miRNA expression profiling that requires proper data normalization. Since there is no universal normalizer, it is recommended to evaluate normalizers under every experimental condition. This study describes the identification of suitable endogenous normalizer(s) […]

Biotechnology Towards Energy Crops

Abstract New crops are gradually establishing along with cultivation systems to reduce reliance on depleting fossil fuel reserves and sustain better adaptation to climate change. These biological assets could be efficiently exploited as bioenergy feedstocks. Bioenergy crops are versatile renewable sources with the potential to alternatively contribute on a daily basis towards the coverage of […]

Intermittent fasting favored the resolution of Salmonella typhimurium infection in middle-aged BALB/c mice

Abstract Intermittent fasting (IF) reportedly increases resistance and intestinal IgA response to Salmonella typhimurium infection in mature mice. The aim of this study was to explore the effect of aging on the aforementioned improved immune response found with IF. Middle-aged male BALB/c mice were submitted to IF or ad libitum (AL) feeding for 40 weeks […]

Spanish teacher faces third cancer with grace – East Oregonian (subscription)

East Oregonian (subscription) Spanish teacher faces third cancer with grace East Oregonian (subscription) Her older students traveled down this road with their teacher two years ago when a tumor was discovered in her sinuses. This time, it popped up as breast cancer. When Youngman learned she would face yet another cancer battle, she gently informed […]

Inhibition of Rho-Associated Protein Kinase Increases the Angiogenic Potential of Mesenchymal Stem Cell Aggregates via Paracrine Effects

Tissue Engineering Part A , Vol. 0, No. 0. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PIj1xF via IFTTT

Congress could expand Downwinders’ compensation – The Daily Courier

The Daily Courier Congress could expand Downwinders’ compensation The Daily Courier … lymphomas (other than Hodgkin’s disease); or primary cancer of the lung, small intestine, brain, thyroid, pancreas, colon, female breast, bile ducts, ovary, male breast, gall bladder, pharynx, esophagus, salivary gland, liver (except if cirrhosis … and more » from #AlexandrosSfakianakis via Alexandros G.Sfakianakis […]

Osteoradionekrose des Sternoklavikulargelenks

Zusammenfassung Hintergrund/Fragestellung Das Auftreten einer Osteoradionekrose nach Bestrahlung im Kopf-Hals-Bereich ist eine seltene, aber gefürchtete Spätkomplikation im Rahmen einer Radiotherapie. Die Lokalisation der Osteoradionekrose im Sternoklavikulargelenk wurde bisher selten beschrieben. Material und Methoden Es handelt sich um eine retrospektive Studie unter Einbezug aller Patienten, welche in den letzten 5 Jahren an der Klinik der Autoren […]

Validation of the contralateral side as reference for selecting radial head implant sizes

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 50 δευτερόλεπτα

Abstract Purpose In arthroplasty of comminuted radial head fractures, the contralateral radial head diameter can be used as reference for implant selection. However, potential bilateral asymmetry may result in a mismatch of the implant with the native bone. Therefore, our purpose was to evaluate anatomical right-to-left differences of radial head diameters. We also compared conventional two-dimensional (2D) with three-dimensional (3D) measurements. Methods We used bilateral CT-scans from 25 intact proximal radius pairs of right-handed adult subjects to obtain 50 3D radial head mo... περισσότερα »

Parental support has positive effect on children’s eating behaviours

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 50 δευτερόλεπτα

Serum midkine as a biomarker for malignancy, prognosis, and chemosensitivity in head and neck squamous cell carcinoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 50 δευτερόλεπτα

Abstract Improved therapies for individuals with head and neck squamous cell carcinoma (HNSCC) may be developed by identification of appropriate biomarkers. The aim of this study was to evaluate the usefulness of serum midkine measurement as a biomarker for HNSCC. Pretreatment serum midkine concentrations were measured in 103 patients with HNSCC and 116 control individuals by enzyme-linked immunosorbent assay. Midkine expression in tumor tissues from 33 patients with HNSCC who underwent definitive surgical resection without preoperative treatment was examined by immunohistochemist... περισσότερα »

The impact of mammographic screening on the surgical management of breast cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 50 δευτερόλεπτα

Background and Objectives Mammographic screening has been shown to result in downward stage migration, reflected by smaller tumor sizes and less extensive nodal involvement. National guidelines restrict screening recommendations in women age 40–49. The purpose of this study is to evaluate the specific impact of mammographic screening patterns on the surgical management of breast cancer in women aged 40–49. Methods The study is a population-based retrospective review of the Vermont Breast Cancer Surveillance System of women aged 40–49 with a diagnosis of breast cancer. Tumor stag...περισσότερα »

Early tissue reaction in the tension zone of PDL during orthodontic tooth movement

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 51 δευτερόλεπτα

Study Finds Beedi Smoking Is a Risk Factor for Gastric Cancer – India West

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

Fatal phenytoin-induced Stevens–Johnson syndrome in an elderly person

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

Fatal phenytoin-induced Stevens–Johnson syndrome in an elderly person with metastatic lung carcinoma: 2016-01-19T11-03-46Z Source: National Journal of Physiology, Pharmacy and Pharmacology Asha Madaiah, Hema Narasimhe Gowda. Health-care providers must be cautious about the adverse effects of drugs, especially StevensJohnson syndrome, which is a potentially fatal condition. Several drugs are at high risk of inducing StevensJohnson… Continue reading Fatal phenytoin-induced Stevens–Johnson syndrome in an elderly person

Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

This document reviews 1) the measurement properties of commonly used exercise tests in patients with chronic respiratory diseases and 2) published studies on their utilty and/or evaluation obtained from MEDLINE and Cochrane Library searches between 1990 and March 2015. Exercise tests are reliable and consistently responsive to rehabilitative and pharmacological interventions. Thresholds for clinically important… Continue reading Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement

Oral hygienic practices and oral health status among school children

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

Study of oral hygienic practices and oral health status among school children in Jabalpur, Madhya Pradesh: a cross-sectional study: 2016-01-20T10-38-04Z Source: International Journal of Community Medicine and Public Health Shashi Prabha Tomar, Pradeep Kumar Kasar, Rajesh Tiwari. Background: Oral hygiene should be educated and practiced at early age as it is one of the determinants… Continue reading Oral hygienic practices and oral health status among school children

A review of national guidelines for management of COPD in Europe

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

The quality of care can be improved by the development and implementation of evidence-based treatment guidelines. Different national guidelines for chronic obstructive pulmonary disease (COPD) exist in Europe and relevant differences may exist among them. This was an evaluation of COPD treatment guidelines published in Europe and Russia in the past 7 years. Each guideline… Continue reading A review of national guidelines for management of COPD in Europe

Traffic-related air pollution and alveolar nitric oxide in southern California children

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

Outcome of patients with right heart thrombi: the Right Heart Thrombi European Registry

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

A previous genome-wide linkage scan of bronchial hyperresponsiveness (BHR) in the French Epidemiological study on the Genetics and Environment of Asthma (EGEA) families, performed in the presence of a genexearly-life environmental tobacco smoke (ETS) exposure interaction, showed the strongest interaction in the 17p11 region where linkage was detected only among unexposed siblings. Our goal was… Continue reading Interaction between the DNAH9 gene and early smoke exposure in bronchial hyperresponsiveness

Rapid identification of Streptococcus pneumoniae in blood cultures by using the ImmuLex, Slidex and Wellcogen latex agglutination tests and the BinaxNOW antigen test

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 59 δευτερόλεπτα

Abstract Rapid identification of Streptococcus pneumoniae in blood culture (BC) bottles is important for early directed antimicrobial therapy in pneumococcal bacteraemia. We evaluated a new latex agglutination (LA) test on BC bottles, the ImmuLex™ S. pneumoniae Omni (Statens Serum Institut, Denmark), and compared the performance with the Slidex® pneumo-Kit (bioMérieux, France) and the Wellcogen™ S.… Continue reading Rapid identification of Streptococcus pneumoniae in blood cultures by using the ImmuLex, Slidex and Wellcogen latex agglutination tests and the BinaxNOW antigen test

Spontaneous Retropharyngeal Hematoma

Spontaneous Retropharyngeal Hematoma from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1ZG9RqN via IFTTT

Brainlab Cranial Image-Guided Surgery (IGS) System: Class I Recall – Navigation Inaccuracy

Brainlab Cranial Image-Guided Surgery (IGS) System: Class I Recall – Navigation Inaccuracy: Audience: Risk Manager, Surgery [Posted 01/15/2016] ISSUE: Brainlab is recalling the Cranial IGS System due to potential inaccuracies in the display by the navigation system compared to the patient anatomy. This could lead to inaccurate,… from #Med Blogs by Alexandros G.Sfakianakis via Alexandros […]

Chrysin alleviates allergic inflammation and airway remodeling

in a murine model of chronic asthma via ScienceDirect Publication: International Immunopharmacology Publication date: March 2016 Source:International Immunopharmacology, Volume 32 Author(s): Jing Yao, Mingzi Jiang, Yunshi Zhang, Xing Liu, Qiang Du, Ganzhu Feng Asthma is a chronic airway inflammatory disorder and progresses mainly due to airway remodeling. Chrysin, a natural flavonoid, has been reported to […]

The Role and Immunobiology of Eosinophils in the Respiratory System: a Comprehensive Review

Abstract The eosinophil is a fully delineated granulocyte that disseminates throughout the bloodstream to end-organs after complete maturation in the bone marrow. While the presence of eosinophils is not uncommon even in healthy individuals, these granulocytes play a central role in inflammation and allergic processes. Normally appearing in smaller numbers, higher levels of eosinophils in […]

Stent Retriever Thrombectomy of Small Caliber Intracranial Vessels Using pREset LITE: Safety and Efficacy

Abstract Purpose Few devices are approved for thrombectomy of distal vessel branches, and clinical experience is limited. Here we report our experience with pREset LITE for thrombectomy of small intracranial vessels. Methods From an institutional database we selected consecutive patients treated with pREset LITE for an occlusion of small (≤ 2 mm), intracranial target vessels. Recanalization […]

Anaphylaxis following a transvaginal ultrasound

Polyethylene glycol is a ubiquitous, water-soluble, organic compound found in a wide variety of commercially available products. While generally a benign substance, in rare instances, it can induce hypersensitivity reactions. Herein, we describe a case of anaphylaxis to polyethylene glycol-containing lubricating gel used for a transvaginal ultrasound. This case highlights the importance of early recognition […]

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea

The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness

Human African trypanosomiasis due to Trypanosoma brucei rhodesiense is invariably fatal if untreated with up to 12.3 million people at a risk of developing the disease in Sub-Saharan Africa. The disease is characterized by a wide spectrum of clinical presentation coupled with differences in disease progression and severity. While the factors determining this varied response […]

Photodynamic therapy with periodic renewal of the photosensitizer on intracanal Enterococcus faecalis biofilms

Monitoring the effectiveness of via ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy Publication date: Available online 18 January 2016 Source:Photodiagnosis and Photodynamic Therapy Author(s): Janir Alves Soares, Suelleng Maria Cunha Santos Soares, Carlos Augusto Santos Sésar, Maria Auxiliadora Roque de Carvalho, Manoel Brito-Júnior, Gerdal Roberto de Sousa, Betânia Maria Soares, Luiz de Macêdo Farias Background and […]

Angry Posture

Angry Posture via ScienceDirect Publication: Journal of Bodywork and Movement Therapies Publication date: Available online 18 January 2016 Source:Journal of Bodywork and Movement Therapies Author(s): Jose Luis Rosário, Maria Suely Bezerra Diógenes, Rita Mattei, José Roberto Leite Postural abnormalities can affect the emotions and vice-versa. The aim of the present study was to investigate the […]

Nouvelles thérapeutiques de la mucoviscidose ciblant le gène ou la protéine CFTR

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Nouvelles thérapeutiques de la mucoviscidose ciblant le gène ou la protéine CFTR via Revue des Maladies Respiratoires Publication date: Available online 21 January 2016 *Source:*Revue des Maladies Respiratoires Author(s): D. Hubert, S. Bui, C. Marguet, V. Colomb-Jung, M. Murris-Espin, H. Corvol, A. Munck IntroductionLe traitement de la mucoviscidose est resté longtemps symptomatique. Des thérapeutiques ciblant la protéine CFTR défectueuse commencent à être disponibles.État des connaissancesLes résultats de la thérapie génique restent modestes mais une étude clinique récente montre un ...περισσότερα »

Airway surfactant protein D (SP-D) deficiency in adults with severe asthma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Airway surfactant protein D (SP-D) deficiency in adults with severe asthma: Background Surfactant protein D (SP-D) is an essential component of the innate immune defence against pathogens within the airways. In addition SP-D regulates allergic inflammation and promotes the removal of apoptotic cells. SP-D dysregulation is evident in several pulmonary diseases. Our aim was to investigate whether airway and serum levels of SP-D are altered in treatment-resistant severe asthma. Methods SP-D concentrations were measured in matched serum and bronchoalveolar lavage (BAL) samples collecte... περισσότερα »

Valsalva Maneuver in Pulmonary Arterial Hypertension: Susceptibility to Syncope and Autonomic Dysfunction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Valsalva Maneuver in Pulmonary Arterial Hypertension: Susceptibility to Syncope and Autonomic Dysfunction: Background Primary arterial hypertension (PAH) patients are routinely instructed to avoid performing the Valsalva maneuver for fear of syncope or sudden cardiac death. The mechanism of this has not been elucidated. We conducted a case-control trial of 9 PAH patients and 15 healthy controls to determine if systemic hemodynamic changes during the Valsalva maneuver in PAH patients invoke greater susceptibility to syncope than healthy controls using metrics commonly employed in au...περισσότερα »

Transdermal fentanyl patch for post operative pain relief

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Double blind randomized comparative study of transdermal fentanyl patch for post operative pain relief in major abdominal surgery as a component of multimodal analgesic therapy: 2016-01-16T11-58-32Z *Source:* International Journal of Basic & Clinical Pharmacology Kalyani Surya Dhanalakshmi Sangineni, Anuradha Deolalkar, S. C. Parakh, D. Dharma Rajuloo. Background: There are various methods of alleviating post-operative pain, multimodal analgesia is the recommended practice. Fentanyl patch can also be used in the management of acute postoperative pain. We have done a study to compa... περισσότερα »

Evaluation of cranial sonography indicies in infants and neonates

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Evaluation of cranial sonography indicies in infants and neonates: 2016-01-16T10-37-40Z *Source:* International Journal of Medical Science and Public Health Vittal Prasad Chinta. Background: Current ultrasound technology allows for evaluation of neonates and infants in the intensive care nursery with virtually no risk. Noninvasive, rapid evaluation of brain in the neonate and infants with reproducible results is now feasible with real-time high-resolution cranial sonography through anterior fontanelle. Objectives: To evaluate the role of cranial sonography in neonates and infants... περισσότερα »

Necrotising fasciitis secondary to varicella in a 14 month old child.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Necrotising fasciitis secondary to varicella in a 14 month old child.: 2016-01-17T03-12-06Z *Source:* Case Study and Case Report Nikhil S Challawar, Sandeep R Prangavane, Parth V Agrawal. Varicella zoster is a common and benign condition in pediatric age group . Necrotizing fasciitis is a very rare complication of varicella. However its knowledge aids in prompt diagnosis, early surgical management and prevention of a life threatening condition. We present a case here highlighting the importance of its early diagnosis.

Fatal phenytoin-induced Stevens–Johnson syndrome in an elderly person

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Fatal phenytoin-induced Stevens–Johnson syndrome in an elderly person with metastatic lung carcinoma: 2016-01-19T11-03-46Z *Source:* National Journal of Physiology, Pharmacy and Pharmacology Asha Madaiah, Hema Narasimhe Gowda. Health-care providers must be cautious about the adverse effects of drugs, especially StevensJohnson syndrome, which is a potentially fatal condition. Several drugs are at high risk of inducing StevensJohnson syndrome including allopurinol, sulfonamides, cephalosporins, quinolones, phenytoin, carbamazepine, and nonsteroidal anti-inflammatory drugs. Owing to h... περισσότερα »

Oral hygienic practices and oral health status among school children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Study of oral hygienic practices and oral health status among school children in Jabalpur, Madhya Pradesh: a cross-sectional study: 2016-01-20T10-38-04Z *Source:* International Journal of Community Medicine and Public Health Shashi Prabha Tomar, Pradeep Kumar Kasar, Rajesh Tiwari. Background: Oral hygiene should be educated and practiced at early age as it is one of the determinants of the health state later in ones life. Considering the fact that there is the rise in the number of dental problems in school going children, the present study was undertaken to find out the oral hygi...περισσότερα »

Parathyroidectomy Decreases Insulin Resistance Index in Patients with Primary Hyperparathyroidism

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Parathyroidectomy Decreases Insulin Resistance Index in Patients with Primary Hyperparathyroidism: AbstractPrimary hyperparathyroidism (PHPT) has been considered a cause of insulin resistance (IR) and impaired glucose metabolism. However, there are conflicting results related with the recovery of insulin resistance in patients with PHPT following curative parathyroidectomy. Our aim is to evaluate the effects of curative parathyroidectomy on IR in patients with PHPT. This is a prospective interventional study. Twenty-one consecutive patients with symptomatic PHPT were included into ...περισσότερα »

Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis—a Case Report

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Malignant Proliferating Trichilemmal Tumour of the Scalp with Intra-Cranial Extension and Lung Metastasis—a Case Report: AbstractMalignant proliferating trichilemmal tumour (MPTT) is a rare cutaneous tumour predominantly affecting the scalp, eyelids, neck and face of elderly women. It is a large, solitary, multilobulated lesion that may arise within a pilar cyst. These tumours are largely benign, often cystic and are characterized by trichilemmal keratinisation. However at times, the tumour has an aggressive clinical course and a propensity for distant metastasis. We report a case ... περισσότερα »

Factors that drive team participation in surgical safety checks

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Factors that drive team participation in surgical safety checks: a prospective study: Abstract BackgroundTeam-based group communications using checklists are widely advocated to achieve shared understandings and improve patient safety. Despite the positive effect checklists have on collaborations and reduced postoperative complications, their use has not been straightforward. Previous research has described contextual factors that impact on the implementation of checklists, however there is limited understanding of the issues that impede team participation in checklist use in surg... περισσότερα »

Spontaneous Retropharyngeal Hematoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Spontaneous Retropharyngeal Hematoma

Brainlab Cranial Image-Guided Surgery (IGS) System: Class I Recall - Navigation Inaccuracy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Brainlab Cranial Image-Guided Surgery (IGS) System: Class I Recall - Navigation Inaccuracy: Audience: Risk Manager, Surgery [Posted 01/15/2016] ISSUE: Brainlab is recalling the Cranial IGS System due to potential inaccuracies in the display by the navigation system compared to the patient anatomy. This could lead to inaccurate,...

Chrysin alleviates allergic inflammation and airway remodeling

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

in a murine model of chronic asthma via ScienceDirect Publication: International Immunopharmacology Publication date: March 2016 *Source:*International Immunopharmacology, Volume 32 Author(s): Jing Yao, Mingzi Jiang, Yunshi Zhang, Xing Liu, Qiang Du, Ganzhu Feng Asthma is a chronic airway inflammatory disorder and progresses mainly due to airway remodeling. Chrysin, a natural flavonoid, has been reported to possess multiple biologic activities, including anti-inflammation, anti-oxidation and anti-proliferation. The present study aimed to investigate whether chrysin could relieve aller... περισσότερα »

Photodynamic therapy with periodic renewal of the photosensitizer on intracanal Enterococcus faecalis biofilms

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Monitoring the effectiveness of via ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy Publication date: Available online 18 January 2016 *Source:*Photodiagnosis and Photodynamic Therapy Author(s): Janir Alves Soares, Suelleng Maria Cunha Santos Soares, Carlos Augusto Santos Sésar, Maria Auxiliadora Roque de Carvalho, Manoel Brito-Júnior, Gerdal Roberto de Sousa, Betânia Maria Soares, Luiz de Macêdo Farias Background and objectivePhotodynamic therapy (PDT) can to eliminate microorganisms in root canal. However, the parameters for disinfection remain undefined. This stu... περισσότερα »

Quantum interference in heterogeneous superconducting-photonic circuits on a silicon chip

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Article Scaling photonic quantum information processing approaches remains challenging for integrated quantum optics. Here, Schuck et al. develop a hybrid superconducting-photonic circuit system to show how quantum interference and single-photon detectors can be combined in a scalable fashion on a silicon chip. Nature Communications doi: 10.1038/ncomms10352 Authors: C. Schuck, X. Guo, L. Fan, X. Ma,… Continue reading Quantum interference in heterogeneous superconducting-photonic circuits on a silicon chip

Visual detection technique for efficient screening and isolation of Salmonella based on a novel enrichment assay using chromatography membrane

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Abstract To detect Salmonella more efficiently and isolate strains more easily, a novel and simple detection method that uses an enrichment assay and two chromogenic reactions on a chromatography membrane was developed. Grade 3 chromatography paper is used as functionalized solid phase support (SPS), which contains specially optimized medium. One reaction for screening is based… Continue reading Visual detection technique for efficient screening and isolation of Salmonella based on a novel enrichment assay using chromatography membrane

Sex- and Age-Specific Reference Values and Cutoff Points for TPOAb: Tehran Thyroid Study

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1S8Cyfi via IFTTT

Conformation and dynamics of the ligand shell of a water-soluble Au102 nanoparticle

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Article The core structure of inorganic nanoparticles, stabilized by a passivating layer of organic molecules, is often known but information about the organic layer is tougher to derive. Here, the authors use NMR and computational methods to probe the ligand disorder and visualize possible ligand conformations. Nature Communications doi: 10.1038/ncomms10401 Authors: Kirsi Salorinne, Sami Malola,… Continue reading Conformation and dynamics of the ligand shell of a water-soluble Au102 nanoparticle

Uncommon TERT Promoter Mutations in Pediatric Thyroid Cancer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Thyroid , Vol. 0, No. 0. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Nosh8q via IFTTT

Dispensing behaviour of pharmacies in prescription drug markets

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Publication date: Available online 21 January 2016 Source:Health Policy Author(s): Dennis Guhl, Tom Stargardt, Udo Schneider, Katharina Fischer ObjectiveWe aim to investigate pharmacies’ dispensing behaviour under the existing dispensing regulations in Germany.MethodsUsing administrative data, we performed a cross-sectional retrospective study to analyse whether the competitive environment and pharmacy characteristics, i.e., organisation, lead to dispensing choices… Continue reading Dispensing behaviour of pharmacies in prescription drug markets

Consumer preferences for over-the-counter drug retailers in the reregulated Swedish pharmacy market

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Publication date: Available online 22 January 2016 Source:Health Policy Author(s): Helle Håkonsen, Karolina Andersson Sundell, Johan Martinsson, Tove Hedenrud Following a large regulatory reform in 2009, which ended the state’s pharmacy monopoly, non-pharmacy retailers in Sweden today sell certain over-the-counter (OTC) drugs. The aim of this study was to investigate consumer preferences regarding OTC drug… Continue reading Consumer preferences for over-the-counter drug retailers in the reregulated Swedish pharmacy market

Manipulating Majorana zero modes on atomic rings with an external magnetic field

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα

Article Majorana fermions, particles which are their own antiparticles, are predicted to exist in systems combining superconductivity and topologically non-trivial band structure. Here, the authors propose means to create and manipulate such excitations in one-dimensional chains of adatoms on superconducting surfaces. Nature Communications doi: 10.1038/ncomms10395 Authors: Jian Li, Titus Neupert, B. Andrei Bernevig, Ali Yazdani… Continue reading Manipulating Majorana zero modes on atomic rings with an external magnetic field

Angry Posture

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Angry Posture via ScienceDirect Publication: Journal of Bodywork and Movement Therapies Publication date: Available online 18 January 2016 *Source:*Journal of Bodywork and Movement Therapies Author(s): Jose Luis Rosário, Maria Suely Bezerra Diógenes, Rita Mattei, José Roberto Leite Postural abnormalities can affect the emotions and vice-versa. The aim of the present study was to investigate the existence of a relationship between subjective anger and body posture in 28 women, aged between 20 and 39 years, with a normal body mass index (or underweight) and an absence of neurological, ps... περισσότερα »

GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies: Summary*Background* Integrin signaling is an attractive target for anti-cancer treatment. GLPG0187 is a broad spectrum integrin receptor antagonist (IRA). GLPG0187 inhibited tumor growth and metastasis in mouse models. *Methods* We aimed to determine the Recommended Phase II Dose (RP2D) and to assess safety and tolerability of continuous i.v. infusion in patients with advanced malignant solid tumors. ... περισσότερα »

EQ-5D Utilities in Chronic Spontaneous/Idiopathic Urticaria

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

EQ-5D Utilities in Chronic Spontaneous/Idiopathic Urticaria: Abstract ObjectivesTo obtain utility estimates suitable for use in economic models for chronic spontaneous (idiopathic) urticaria (CSU). MethodsPatient-level data from three randomized clinical trials—ASTERIA I, ASTERIA II and GLACIAL—were analysed. Health states were derived from the Urticaria Activity Score over 7 days (UAS7); higher scores denote greater activity. The health state score ranges were urticaria free: 0; well-controlled urticaria: 1–6; mild urticaria: 7–15; moderate urticaria: 16–27; and severe urticar... περισσότερα »

Antimicrobial photodynamic therapy in the management of chronic periodontitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Patients' perceptions of via ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy Publication date: Available online 21 January 2016 *Source:*Photodiagnosis and Photodynamic Therapy Author(s): Joseph Betsy, Chandra Sekhar Prasanth, Kamalasanan Vijayakumari Baiju, Janam Prasanthila, Narayanan Subhash The aim of this study is to evaluate patients' perception of antimicrobial photodynamic therapy (aPDT) in the management of chronic periodontitis. 90 patients (51 females and 39 males) with untreated localized chronic periodontitis were randomly assigned to receive SRP with aP... περισσότερα »

ALA-PDT inhibits proliferation and promotes apoptosis of SCC cells through STAT3 Signal Pathway

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

ALA-PDT inhibits proliferation and promotes apoptosis of SCC cells through STAT3 Signal Pathway via ScienceDirect Publication: Photodiagnosis and Photodynamic Therapy Publication date: Available online 21 January 2016 *Source:*Photodiagnosis and Photodynamic Therapy Author(s): Li Qiao, Zhusong Mei, Zhiyong Yang, Xinji Li, Hong Cai, Wei Liu The previous studies suggest that apoptosis of carcinoma cells led by photodynamics is mainly intrinsic apoptosis, but whether the extrinsic pathway is involved in the treatment of carcinoma by photodynamic therapy is not confirmed. This research inve... περισσότερα »

Single nucleotide polymorphisms in DNA repair genes and the risk of laryngeal cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

: A meta-analysis via Biomedicine & Pharmacotherapy Publication date: March 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 78 Author(s): Fujun Li, Jing Wang, Ming Chen Laryngeal cancer is the most common type of head and neck cancer with poor prognosis and high relapse rate. Several genes involved in DNA repair pathways have been identified for their potential role in laryngeal cancer risk. However, the results remain inconclusive. The aim of this study was to investigate the association between polymorphisms of XRCC1 Arg399Gln, XRCC3 Thr241Met, and XPD Lys751Gln and laryngeal can... περισσότερα »

Antibody-Drug Conjugates: A Clinical Pharmacy Perspective on an Emerging Cancer Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Antibody-Drug Conjugates: A Clinical Pharmacy Perspective on an Emerging Cancer Therapy: Antibody-drug conjugates (ADCs) combine highly specific monoclonal antibodies with potent cytotoxic drugs. Their synergy allows for targeted delivery of toxic drugs to cancer cells while sparing systemic exposure. In this review, we focus on the history and clinical applications of ADCs approved by the U.S. Food and Drug Administration (FDA) for the treatment of cancer and highlight new ADCs in the drug development pipeline. Three ADCs have received FDA approval thus far. Gemtuzumab ozogamicin,...περισσότερα »

Graves' Disease Pharmacotherapy in Women of Reproductive Age

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Graves' Disease Pharmacotherapy in Women of Reproductive Age: Graves' disease is an autoimmune disorder in which inappropriate stimulation of the thyroid gland results in unregulated secretion of thyroid hormones resulting in hyperthyroidism. Graves' disease is the most common cause of autoimmune hyperthyroidism during pregnancy. Treatment options for Graves' disease include thioamide therapy, partial or total thyroidectomy, and radioactive iodine. In this article, we review guideline recommendations for Graves' disease treatment in women of reproductive age including the recent gu...περισσότερα »

Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 1 ώρα

Summary Neonatal exposure to monosodium glutamate (MSG) induces circadian disorders in several physiological and behavioural processes regulated by the suprachiasmatic nucleus (SCN). The objective of this study was to evaluate the effects of neonatal exposure to MSG on locomotor activity, and on morphology, cellular density and expression of proteins, as evaluated by optical density (OD), of vasopressin (VP)-, vasoactive intestinal polypeptide (VIP)- and glial fibrillary acidic protein (GFAP)-immunoreactive cells in the SCN. Male Wistar rats were used: the MSG group was subcutaneo...περισσότερα »

Adrenal and extra-adrenal functions of ACTH

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

The pituitary adrenocorticotropic hormone (ACTH) plays a pivotal role in homeostasis and stress response and is thus the major component of the hypothalamo-pituitary-adrenal (HPA) axis. After a brief summary of ACTH production from proopiomelanocortin (POMC) and on the ACTH receptor properties, the first part of the review covers the roles of ACTH in steroidogenesis and […]

How to Reduce Head CT Orders in Children with Hydrocephalus Using the Lean Six Sigma Methodology: Experience at a Major Quaternary Care Academic Children’s Center PEDIATRICS

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

BACKGROUND AND PURPOSE: Lean Six Sigma methodology is increasingly used to drive improvement in patient safety, quality of care, and cost-effectiveness throughout the US health care delivery system. To demonstrate our value as specialists, radiologists can combine lean methodologies along with imaging expertise to optimize imaging elements-of-care pathways. In this article, we describe a Lean […]

Manipulating Majorana zero modes on atomic rings with an external magnetic field

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

4π-periodic Josephson supercurrent in HgTe-based topological Josephson junctions

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Article A material weakly linking two superconductors may itself exhibit superconductivity whilst its material properties strongly influence the nature of the supercurrent. Here, the authors identify a supercurrent with p -wave symmetry in such a Josephson junction made of topologically non-trivial material. Nature Communications doi: 10.1038/ncomms10303 Authors: J. Wiedenmann, E. Bocquillon, R. S. Deacon, S. […]

Pin1At regulates PIN1 polar localization and root gravitropism

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Article Asymmetric transport of auxin allows plants to orient growth of their roots towards gravity. Here, the authors show that the peptidyl-prolyl cis/trans isomerase Pin1At contributes to root gravitropism and propose that it acts by altering the polarity of the PIN1 auxin transport protein. Nature Communications doi: 10.1038/ncomms10430 Authors: Wanyan Xi, Ximing Gong, Qiaoyun Yang, […]

The novel tumour suppressor Madm regulates stem cell competition in the Drosophila testis

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Article Stem cell competition mediates the balance between tissue homeostasis and tumour formation, but how this occurs is unclear. Here, Singh et al. show that the tumour suppressor Mlfl-adaptor molecule regulates the balance between germline stem cell and somatic cyst stem cell growth in the Drosophila testis niche. Nature Communications doi: 10.1038/ncomms10473 Authors: Shree Ram […]

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Article Direct visualisation of heterogeneous cell populations in live animals has been challenging. Here, the authors optimize cell transplantation into optically clear immune-deficient zebrafish, and use intravital imaging to track and to assess functional diversity of individual cancer cells in vivo . Nature Communications doi: 10.1038/ncomms10358 Authors: Qin Tang, John C. Moore, Myron S. Ignatius, […]

Engineered Mott ground state in a LaTiO3+δ/LaNiO3 heterostructure

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Article Interfaces between two dissimilar transition metal oxides can exhibit emergent strongly correlated electronic and magnetic states due to charge transfer and electronic reconfiguration. Here, the authors synthesize and investigate an exotic Mott ground state in LaTiO 3+δ /LaNiO 3 heterostructures. Nature Communications doi: 10.1038/ncomms10418 Authors: Yanwei Cao, Xiaoran Liu, M. Kareev, D. Choudhury, S. […]

Conformation and dynamics of the ligand shell of a water-soluble Au102 nanoparticle

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Article Decrease in Apolipoprotein C-III (ApoC-III) yields a cardioprotective lipoprotein profile. Here, Valleix et al. reveal a novel ApoC-III variant conferring low plasma ApoC-III concentration and cardioprotection despite renal insufficiency, and, unexpectedly, causing dominant hereditary systemic amyloidosis due to its fibrillogenic nature. Nature Communications doi: 10.1038/ncomms10353 Authors: Sophie Valleix, Guglielmo Verona, Noémie Jourde-Chiche, Brigitte Nédelec, […]

Anaphylaxis following a transvaginal ultrasound

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

The role of cytokines in the pathogenesis and staging of Trypanosoma brucei rhodesiense sleeping sickness

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Myeloid Acyl-CoA:cholesterol acyltransferase 1 deficiency reduces lesion macrophage content and suppresses atherosclerosis progression Lipids

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Acyl-CoA:cholesterol acyltransferase 1 (Acat1) converts cellular cholesterol to cholesteryl esters and is considered as a drug target for treating atherosclerosis. However, in mouse models for atherosclerosis, global Acat1 knockout (Acat1-/-) did not prevent lesion development; Acat1-/- increased apoptosis within lesion, and led to several additional undesirable phenotypes including hair loss, dry eye, leukocytosis, xanthomatosis, and […]

Circadian clock in a mouse colon tumor regulates intracellular iron levels to promote tumor progression Metabolism

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Iron is an important biological catalyst and is critical for DNA synthesis during cell proliferation. Cellular iron uptake is enhanced in tumor cells to support increased DNA synthesis. Circadian variations in DNA synthesis and proliferation have been identified in tumor cells, but their relationship with intracellular iron levels is unclear. In this study, we identified […]

Interaction of Bacillus subtilis Polynucleotide Phosphorylase and RNase Y: Structural Mapping and Effect on mRNA Turnover RNA

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Polynucleotide phosphorylase (PNPase), a 3′-to-5′ phosphorolytic exoribonuclease, is thought to be the primary enzyme responsible for turnover of Bacillus subtilis mRNA. The role of PNPase in B. subtilis mRNA decay has been analyzed previously by comparison of mRNA profiles in a wild-type strain vs. a strain that is deleted for pnpA, the gene encoding PNPase. […]

Modulation of DNA Polymerase Noncovalent Kinetic Transitions by Divalent Cations Enzymology

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Replicative DNA polymerases (DNAPs) require divalent metal cations for phosphodiester bond formation in the polymerase site and for hydrolytic editing in the exonuclease site. Me2+ ions are intimate architectural components of each active site, where they are coordinated by a conserved set of amino acids and functional groups of the reaction substrates. Therefore Me2+ ions […]

NANOG binds to GLI proteins and represses Hedgehog-mediated transcription Gene Regulation

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

The Hedgehog (HH) signaling pathway is essential for the maintenance and response of several types of stem cells. To study the transcriptional response of stem cells to HH signaling, we searched for proteins binding to GLI proteins, the transcriptional effectors of the HH pathway in mouse embryonic stem (ES) cells. We find that both GLI3 […]

A systematic investigation of structure/function requirements for the apolipoprotein A-I – lecithin cholesterol acyltransferase interaction loop of HDL Molecular Bases of Disease

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

The interaction of lecithin-cholesterol acyl transferase (LCAT) with apolipoprotein A-I (apoA-I) plays a critical role in high-density lipoprotein HDL maturation. We previously identified a highly solvent-exposed apoA-I loop domain (L159-L170) in nascent HDL, the so-called ‘solar flare’ (SF) region, and proposed it serves as an LCAT docking site (Wu et al, Nat Struct Mol Biol […]

Protein kinase A (PKA) Type I interacts with P-Rex1, a Rac guanine nucleotide exchange factor: Effect on PKA localization and P-Rex1 signaling Cell Biology

sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα

Morphology of migrating cells is regulated by Rho GTPases and fine-tuned by protein interactions and phosphorylation. PKA affects cell migration potentially through spatio-temporal interactions with regulators of Rho GTPases. Here we show that endogenous regulatory (R) subunit of type I PKA interacts with P-Rex1, a Rac guanine nucleotide exchange factor that integrates chemotactic signals. Type […]

Isolated bony syngnathia

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 1 ώρα

Publication date: Available online 20 January 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Sanjeev Kumar, Bharat Bhati, Pankaj Kukreja, Vijay Mishra, Alok Bhatnagar from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1NnKIKo via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Image-guided Cryoablation of Head, Neck and Spine Tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Image-guided Cryoablation of Head, Neck and Spine Tumors: *Conditions*: Head and Neck Neoplasms; Malignant Neoplasm of Vertebral Column *Interventions*: Procedure: Cryoablation; Device: Biopsy *Sponsor*: Dana-Farber Cancer Institute ArmsAssigned InterventionsExperimental: Image-guided cryoablation +/- biopsy - MRI/PET/CT imaging in the Advanced Multimodality Image Guided Operating (AMIGO) suite used to place cryoablation needle(s) into target lesion (Mean: 3 cryoprobes, Range: 1-10). - MR/PET/CT imaging in the AMIGO suite will monitor two 15-minute freeze ...περισσότερα »

The loss of cerebral spinal fluid and hence the drop in intracranial pressure can result in hearing loss and cranial nerve palsy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Sudden Sensorineural Hearing Loss after Orthopedic Surgery under Combined Spinal and Epidural Anesthesia: Postoperative hearing loss following nonotologic surgery is rare. For patients undergoing subarachnoid anesthesia, the loss of cerebral spinal fluid and hence the drop in intracranial pressure can result in hearing loss and cranial nerve palsy. We report a case in which a patient sustained orthopedic surgery under combined spinal and epidural anesthesia complicated by severe and persistent sensorineural hearing loss. This report is a reminder that postoperative sudden sensorineu...περισσότερα »

Sudden Sensorineural Hearing Loss after Orthopedic Surgery under Combined Spinal and Epidural Anesthesia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Getting the Most From Cochlear Implants

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Getting the Most From Cochlear Implants: It is no longer true that cochlear implantation is considered successful if the device simply provides some access between a deaf person and the surrounding auditory world. Our expectations for implants have grown so much that we now aspire for them to create or restore normal or near-normal hearing. As binaural creatures, we intuitively grasp that this goal requires bilateral, rather than unilateral, implantation to achieve the same advantages of sound localization and improved hearing in noise that 2 ears provide to normal listeners. [i... περισσότερα »

Mastoid Mass With Associated Pulmonary Cystic Lesions

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Mastoid Mass With Associated Pulmonary Cystic Lesions: A young woman had otalgia, intermittent rotary vertigo, protrusion of the auricle, and mastoid erythema and tenderness; CT revealed an expansile mass in the mastoid cavity and multiple bilateral cystic lesions and reticular nodular densities. What is your diagnosis? [image: First page PDF preview]

Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma.Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC diagnosis but is not associated with differences in survival outcomes.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Prognosis and Clinical Outcomes of Mucoepidermoid Carcinoma: This medical record review examines whether the CRTC1/MAML2 fusion transcript is associated with disease stage, tumor grade, and survival in patients with mucoepidermoid carcinoma. *Importance* The *CRTC1/MAML2* fusion transcript, which arises from the *CRTC1/MAML2*translocation, is a molecular marker unique to mucoepidermoid carcinoma (MEC), the most common malignant tumor of the salivary gland. The extent to which the transcript influences disease features and patient survival is unclear. *Objective* To determine wh... περισσότερα »

Mercury resistance transposons in Bacilli strains from different geographical regions

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

Sixty-five spore-forming mercury-resistant bacteria were isolated from natural environments worldwide in order to understand the acquisition of additional genes by and dissemination of mercury resistance transposons across related Bacilli genera by horizontal gene movement. PCR amplification using a single primer complementary to the inverted repeat (IR) sequence of Tn*MERI1*-like transposons showed that 12 of 65 isolates had a transposon-like structure. There were four types of amplified fragments: Tn*5084*, Tn*5085*, Tnd*MER3* (a newly identified deleted transposon-like fragment... περισσότερα »

Pseudomonas putida KT2440 markerless gene deletion using a combination of {lambda} Red recombineering and Cre/loxP site-specific recombination

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα

*Pseudomonas putida* KT2440 is a saprophytic, environmental microorganism that plays important roles in the biodegradation of environmental toxic compounds and production of polymers, chemicals, and secondary metabolites. Gene deletion of KT2440 usually involves cloning of the flanking homologous fragments of the gene of interest into a suicide vector followed by transferring into KT2440 via tri-parental conjugation. Selection and counterselection steps are then employed to generate gene deletion mutant. However, these methods are tedious and are not suitable for the manipulation ...περισσότερα »

Comparison of Bilateral and Unilateral Cochlear Implantation in Adults

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Comparison of Bilateral and Unilateral Cochlear Implantation in Adults: This clinical trial examines the benefits of simultaneous bilateral cochlear implantation compared with unilateral cochlear implantation in adults with postlingual deafness. *Importance* The cost of bilateral cochlear implantation (BCI) is usually not reimbursed by insurance companies because of a lack of well-designed studies reporting the benefits of a second cochlear implant. *Objective* To determine the benefits of simultaneous BCI compared with unilateral cochlear implantation (UCI) in adults with postl... περισσότερα »

Persistent Temporal Bone Lesion After Vestibular Schwannoma Resection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Persistent Temporal Bone Lesion After Vestibular Schwannoma Resection: Two years after a woman underwent a retrosigmoid approach for gross resection of a vestibular schwannoma, follow-up imaging revealed residual tumor growth and a region of enhancing tissue involving the left mastoid and jugular foramen. What is your diagnosis? [image: First page PDF preview]

The impact of topical and systemic enoxaparin sodium use on traumatic tympanic membrane perforation and myringosclerosis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

The impact of topical and systemic enoxaparin sodium use on traumatic tympanic membrane perforation and myringosclerosis: AbstractThe objective of this study is to investigate the effect of topical and systemic enoxaparin sodium on the healing pattern of experimentally induced tympanic membrane perforation and formation of myringosclerosis. A total of 24 Wistar-Albino strain rats were included in the study. Standard myringotomies were performed on each rat. In the first group, isotonic serum physiologic was dropped on external ear canal (control group). Topical enoxaparin was dropp...περισσότερα »

Treatment of ameloblastoma and ameloblastic carcinoma with radiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Treatment of ameloblastoma and ameloblastic carcinoma with radiotherapy: AbstractThe purpose of this study is to report our institutional experience using radiotherapy in the treatment of ameloblastoma and ameloblastic carcinoma. Three patients with ameloblastoma and 3 patients with ameloblastic carcinoma were treated with radiotherapy alone (2 patients) or surgery and postoperative radiotherapy (4 patients) at the University of Florida between 1973 and 2007. Follow-up ranged from 4.0 to 13.1 years with a median of 7.8 years. Radiotherapy complications were scored using the Common ...περισσότερα »

Meniere's disease: importance of socioeconomic and environmental factors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Re: Meniere's disease: importance of socioeconomic and environmental factors: I read with great interest the recent article by Simo et al. [1] and applaud their efforts to further elucidate the descriptive epidemiology of Meniere’s disease. Although not perfect, large administrative databases offer the most cost effective way to attempt to define the disease burden in relatively rare diseases.

Uncommon TERT Promoter Mutations in Pediatric Thyroid Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Uncommon TERT Promoter Mutations in Pediatric Thyroid Cancer: Thyroid , Vol. 0, No. 0. Author information Ali S. Alzahrani,1,2 Ebtesam Qasem,1 Avaniyapuram Kannan Murugan,1 Hindi N. Al-Hindi,3 Dania AlKhafaji,2 Mai Almohanna,1 Mingzhao Xing,4 Doha Alhomaidah ,5 and Meshael AlSwailem1 1Department of Molecular Oncology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. 2Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. 3Department of Pathology & Laboratory Medicine, King Faisal Specialist Hospital & Research Centre... περισσότερα »

Sex- and Age-Specific Reference Values and Cutoff Points for TPOAb

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Sex- and Age-Specific Reference Values and Cutoff Points for TPOAb: Tehran Thyroid Study: Thyroid , Vol. 0, No. 0. Author information Atieh Amouzegar,1 Mahmood Bakhtiyari,1,2 Mohammad Ali Mansournia,2 Ali Etemadi,1 Ladan Mehran,1Maryam Tohidi,3 and Fereidoun Azizi1 1Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 3Prevention of Metabolic Disorder Research Center, Research Insti... περισσότερα »

Osteoradionekrose des Sternoklavikulargelenks

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα

Osteoradionekrose des Sternoklavikulargelenks: Zusammenfassung Hintergrund/FragestellungDas Auftreten einer Osteoradionekrose nach Bestrahlung im Kopf-Hals-Bereich ist eine seltene, aber gefürchtete Spätkomplikation im Rahmen einer Radiotherapie. Die Lokalisation der Osteoradionekrose im Sternoklavikulargelenk wurde bisher selten beschrieben. Material und MethodenEs handelt sich um eine retrospektive Studie unter Einbezug aller Patienten, welche in den letzten 5 Jahren an der Klinik der Autoren aufgrund einer Osteoradionekrose des Sternoklavikulargelenks behandelt wurden. Therap...περισσότερα »

Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Issue Information - Journal Information

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1P9pTrN via IFTTT

Issue Information - TOC

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1PrRO1O via IFTTT

Clinical evaluation of panel testing by next-generation sequencing (NGS) for gene mutations in myeloid neoplasms

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Background: Genomic techniques in recent years have allowed the identification of many mutated genes important in the pathogenesis of acute myeloid leukemia (AML). Together with cytogenetic aberrations, these gene mutations are powerful prognostic markers in AML and can be used to guide patient management, for example selection of optimal post-remission therapy. The mutated genes also hold promise as therapeutic targets themselves. We evaluated the applicability of a gene panel for the detection of AML mutations in a diagnostic molecular pathology laboratory. Methods: Fifty patien...περισσότερα »

SSTR2 promoter hypermethylation is associated with the risk and progression of laryngeal squamous cell carcinoma in males

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα

Background: Somatostatin receptor 2 (SSTR2) encodes somatostatin receptor that can inhibit the cell proliferation of solid tumors. Promoter hypermethylation is likely to silence the expression of SSTR2. The goal of our study was to investigate the association between SSTR2 promoter methylation and the risk and progression of laryngeal carcinoma. Methods: In the current study, tumor tissues and their adjacent non-tumor tissues were collected from a total of 87 laryngeal squamous cell carcinoma (LSCC) male patients. DNA methylation levels of nine SSTR2 promoter CpGs were measured us... περισσότερα »