Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τετάρτη 17 Φεβρουαρίου 2016

OtoRhinoLaryngology & Medicine,New Articles,February 17th,2016,a


Enquiring About Tolerance (EAT) study: Feasibility of an early allergenic food introduction regimen

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
Publication date: Available online 17 February 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Michael R. Perkin, Kirsty Logan, Tom Marrs, Suzana Radulovic, Joanna Craven, Carsten Flohr, Gideon Lack BackgroundThe influence of early exposure to allergenic foods on the subsequent development of food allergy remains uncertain.ObjectiveWe sought to determine the feasibility of the early introduction of multiple allergenic foods to exclusively breast-fed infants from 3 months of age and the effect on breastfeeding performance.MethodsWe performed a randomized controlle... περισσότερα »

Omega-3 fatty acids as an adjunct for periodontal therapy—a review

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
Abstract Objectives The aim of this article is to present an overview of omega-3 fatty acids, their anti-inflammatory properties and potential use as an adjunct for periodontal therapy. Materials and methods A general literature search was conducted to provide an overview of omega-3 fatty acids, their metabolism and anti-inflammatory properties. A more specific literature search of PubMed and EMBASE was conducted to identify articles dealing studies investigating the effects of omega-3 fatty acids in the treatment of periodontitis in animals and humans and included cross-sectiona... περισσότερα »

Persistent swollen lips

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Persistent swollen lips in a 12-year-old girl: A 12-year-old girl presented with a 3-month history of persistent lip swelling. The physical examination revealed marked enlargement of the lower lip and moderate swelling of the upper lip (Fig 1). She was otherwise healthy. A biopsy specimen of the lip was obtained, and it revealed nonnecrotizing granulomas (Fig 2). A complete blood cell count, chest radiograph, purified protein derivative skin test, antineutrophil cytoplasmic antibodies, and neutrophil function tests were negative. A colonoscopy revealed no significant findings.

Lack of promoter mutations in melanomas with extensive regression

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Lack of promoter mutations in melanomas with extensive regression: To the Editor: The recently discovered TERT promoter mutations have been shown to play an important role in melanoma pathogenesis.1 These mutations imply an increased gene expression, with the restoration of telomerase activity and the stabilization of telomeres length.2 Interestingly, some authors have described absence of telomerase activity and shortening of telomeres in regressing swine melanoma cell lines.3 Therefore, although most studies have focused on immunologic response to explain spontaneous regression, t... περισσότερα »

Meningeosis carcinomatosa

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 3 δευτερόλεπτα
Meningeosis carcinomatosa: Zusammenfassung HintergrundDer Befall der Hirnhäute im Rahmen von Karzinomen – Meningeosis carcinomatosa – ist eine in ihrer Häufigkeit unterschätzte Komplikation meist fortgeschrittener Erkrankungen. FragestellungEs werden Inzidenz und Mortalität der Menigeosis carcinomatosa, ihre klinische Präsentation, Diagnostik sowie die aktuellen Therapieempfehlungen dargestellt. Material und MethodeFür den vorliegenden Beitrag wurden die verfügbare Literatur ausgewertet, eigene Beobachtungen beschrieben sowie Grundlagenarbeiten und Expertenempfehlungen disk... περισσότερα »

Specific allergen immunotherapy for the treatment of atopic eczema

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Specific allergen immunotherapy for the treatment of atopic eczema: Abstract Background Specific allergen immunotherapy (SIT) is a treatment that may improve disease severity in people with atopic eczema (AE) by inducing immune tolerance to the relevant allergen. A high quality systematic review has not previously assessed the efficacy and safety of this treatment. Objectives To assess the effects of specific allergen immunotherapy (SIT), including subcutaneous, sublingual, intradermal, and oral routes, compared with placebo or a standard treatment in people with atopic e... περισσότερα »

Detoxification treatment in chronic headache associated with medication overuse

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Psychological factors associated with failure of detoxification treatment in chronic headache associated with medication overuse: Aim The aim of this study was to evaluate the psychological factors associated with a negative outcome following detoxification in a 2-month follow-up in medication-overuse headache. Methods All consecutive patients entering the detoxification program were analysed in a prospective, non-randomised fashion. Psychiatric conditions and personality characteristics were assessed using the Structured Clinical Interview for DSM-IV Disorders (SCID-I) and the Min... περισσότερα »

Subependymal giant cell astrocytoma (SEGA)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Subependymal giant cell astrocytoma (SEGA): a case report and review of the literature: Background: Subependymal giant cell astrocytoma is a rare tumor that occurs in the wall of the lateral ventricle and foramen of Monro and, rarely, in the third ventricle. It is one of the intracranial lesions found in tuberous sclerosis complex (which include subependymal nodules, cortical tubers, retinal astrocytoma and subependymal giant cell astrocytoma), but cases without such lesions have also been reported in the literature. It was described for the first time in 1908 by Vogt as part of the... περισσότερα »

Simultaneous and sequential hemorrhage of multiple cerebral cavernous malformations: a case report

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Simultaneous and sequential hemorrhage of multiple cerebral cavernous malformations: a case report: [image: sfx_links?getImage] Background: The etiology of cerebral cavernous malformation hemorrhage is not well understood. Causative physiologic parameters preceding hemorrhagic cavernous malformation events are often not reported. We present a case of an individual with sequential simultaneous hemorrhages in multiple cerebral cavernous malformations with a new onset diagnosis of hypertension.Case presentationA 42-year-old white man was admitted to our facility with worsening heada... περισσότερα »

Recurrent massive haemoptysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Non-bronchial collateral arising from the right vertebral artery: a rare cause of recurrent massive haemoptysis: Description A 48-year-old man with recurrent episodes of massive haemoptysis was referred to us for bronchial artery embolisation (BAE). He had been treated for pulmonary tuberculosis 6 years earlier. Chest X-ray showed a fibrocavitory lesion in the right upper lobe. A descending thoracic aortogram was carried out, which revealed neither hypertrophied bronchial arteries nor systemic collaterals. Bilateral pulmonary angiogram was normal. Selective injections of bronchial, ... περισσότερα »

Non-bronchial collateral arising from the right vertebral artery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Non-bronchial collateral arising from the right vertebral artery: a rare cause of recurrent massive haemoptysis: Description A 48-year-old man with recurrent episodes of massive haemoptysis was referred to us for bronchial artery embolisation (BAE). He had been treated for pulmonary tuberculosis 6 years earlier. Chest X-ray showed a fibrocavitory lesion in the right upper lobe. A descending thoracic aortogram was carried out, which revealed neither hypertrophied bronchial arteries nor systemic collaterals. Bilateral pulmonary angiogram was normal. Selective injections of bronchial, ... περισσότερα »

Partial Obstruction of the Endotracheal Tube by the Plastic Coating Sheared from a Stylet

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Partial Obstruction of the Endotracheal Tube by the Plastic Coating Sheared from a Stylet: A preterm with gestational age of 24 weeks was intubated at day of life 16. The intubation was done in a routine manner with the use of a stylet. It took a significant effort from the clinician to pull the stylet out after intubation. After intubation the respiratory status of the neonate deteriorated requiring significantly greater support. When ventilating and oxygenating the infant was getting progressively difficult, the decision was made to change the endotracheal tube (ETT). The cause for... περισσότερα »

Capillary haemangioma on the palate

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Capillary haemangioma on the palate: a diagnostic conundrum: Haemangiomas are benign tumours of blood vessel origin and are classified as capillary, cavernous or central. They appear as flat or raised reddish-blue lesions and are generally solitary, affecting women in younger age groups. The tumour may be slowly progressive, involving extensive portions of the superficial and deep blood vessels, and affect function, depending on location. They are common in the head and neck region but rarely in the oral cavity. Oral lesions generally appear on the lips, buccal mucosa and tongue, b... περισσότερα »

Pregnancy tumour of the external auditory canal

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Pregnancy tumour of the external auditory canal: treatment in clinic: We present the case of a 29-year-old woman with a symptomatic lobular capillary haemangioma (pregnancy tumour) arising from the external ear canal. A literature review shows this to be an uncommon lesion in a rare location. The lesion was successfully diagnosed and treated in clinic with complete resolution and no recurrence.

Hypokalaemia and drinking green tea

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Hypokalaemia and drinking green tea: a literature review and report of 2 cases: We report the association between excessive consumption of green tea and hypokalaemia in an Oriental couple. Both patients were asymptomatic and the abnormal electrolyte level was only detected on routine blood tests. When they were advised to reduce the consumption of green tea, the abnormally low potassium level was reversed. We have not found such an association reported in the medical literature. The health benefits of green tea consumption are well publicised but the potential side-effects of over... περισσότερα »

Spontaneous pituitary apoplexy during the second trimester of pregnancy, with sensory loss

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Spontaneous pituitary apoplexy during the second trimester of pregnancy, with sensory loss: A 32-year-old Hispanic woman at 23 weeks gestation presented with right-sided headache, associated with photophobia and right-sided numbness. She denied visual problems, menstrual irregularities and galactorrhoea. Examination revealed visual acuity 20/40 bilaterally with some blurriness on the left side, decreased right V1-V2 facial sensation and preserved 5/5 power, but decreased sensation over the entire right upper extremity (RUE) and right lower extremity (RLE) to touch and pinprick. Lab... περισσότερα »

Rivaroxaban and retropharyngeal haemorrhage

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Rivaroxaban and retropharyngeal haemorrhage: Haemorrhage is a well-known and accepted complication of anticoagulation. A retropharyngeal haemorrhage (RH) is a rare condition that without prompt recognition and management may result in fatal complications. We report a case of RH in a 67-year-old man anticoagulated with rivaroxaban for atrial fibrillation. The patient presented to the emergency department, with a two-day history of atraumatic right-sided neck swelling and associated progressive odynophagia, dysphagia and dysphonia. Rivaroxaban is a potent new oral anticoagulant that ... περισσότερα »

Primary high-grade neuroendocrine carcinoma emerging from an adenomatous polyp in the setting of familial adenomatous polyposis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Primary high-grade neuroendocrine carcinoma emerging from an adenomatous polyp in the setting of familial adenomatous polyposis: Familial adenomatous polyposis (FAP) is a rare inherited syndrome that is characterised by innumerable adenomas of the colon and rectum, a high risk of colorectal cancer and a variety of extracolonic manifestations. FAP presents as hundreds to thousands of colonic adenomas beginning in adolescence. The syndrome is associated with less than 1% of all colorectal cancer cases, but there is a nearly 100% lifetime risk of colorectal cancer in individuals with ... περισσότερα »

Omega-3 fatty acids as an adjunct for periodontal therapy—a review

Abstract Objectives The aim of this article is to present an overview of omega-3 fatty acids, their anti-inflammatory properties and potential use as an adjunct for periodontal therapy. Materials and methods A general literature search was conducted to provide an overview of omega-3 fatty acids, their metabolism and anti-inflammatory properties. A more specific literature search […]

Atelectasis After Endoscopic Resection: Relations and Prediction

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 7 δευτερόλεπτα
from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1QkNrwg via IFTTT

Knöcherne Tränenwegstenose und auffällige Hände als Hinweis auf eine Systemerkrankung

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1U7DCRZ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

A penny for our thoughts? Copper influx key to brain cell development

Researchers at Johns Hopkins have used a precision sensor in a chicken embryo to find dramatic differences in the use of copper between developing and fully mature neurons. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KWflfv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

TAxI shuttles protein cargo into spinal cord

A small peptide, TAxI, holds hope for administering treatments for motor neuron disorders via a muscle injection.A small peptide dubbed TAxI is living up to its name. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20DJMcv via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Researchers identify biomarker for early cognitive decline in Parkinson’s disease patients

Many patients with Parkinson’s Disease (PD) develop mild cognitive impairment (MCI) or dementia. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KWfkZ1 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

UT Southwestern scientists find potential treatment for Friedreich’s ataxia

Researchers at UT Southwestern Medical Center have identified synthetic RNA and DNA that reverses the protein deficiency causing Friedreich’s ataxia, a neurological disease for which there is… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20DJMcc via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

The Ethics of Cloud Computing

Abstract Cloud computing is rapidly gaining traction in business. It offers businesses online services on demand (such as Gmail, iCloud and Salesforce) and allows them to cut costs on hardware and IT support. This is the first paper in business ethics dealing with this new technology. It analyzes the informational duties of hosting companies that […]

Gender-Typed Play and Social Abilities in Boys and Girls: Are They Related?

Abstract In the present study, we tested whether children’s play with feminine toys is related to social abilities in which girls typically excel. We measured gender-typed toy play, empathy, and comforting skill in 80 Grade 1 children (about 6 years-old) in Hong Kong, China. Toy play was assessed with a standard observational paradigm; empathy, with […]

Editorial Board

Publication date: March 2016 Source:Journal of Cranio-Maxillofacial Surgery, Volume 44, Issue 3 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20DJNx3 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

EACMFS Prizes and Awards

Publication date: March 2016 Source:Journal of Cranio-Maxillofacial Surgery, Volume 44, Issue 3 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1KWfkrW via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Announcements

Publication date: March 2016 Source:Journal of Cranio-Maxillofacial Surgery, Volume 44, Issue 3 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20DJLoQ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Long-standing meningomyelocele can be a predictor of difficult airway and postoperative hypoventilation: challenge to the anaesthesiologist

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Long-standing meningomyelocele can be a predictor of difficult airway and postoperative hypoventilation: challenge to the anaesthesiologist: A 15-year-old female patient presented with severe pain in the abdomen and obstructive uropathy. She underwent Yang-Monti ileovesicostomy under general anaesthesia. She is a known case of long-standing meningomyelocele (MMC) and presented with its potential complications such as difficult airway and restrictive lung disease. We describe the successful anaesthetic management of a case of anticipated difficult airway and postoperative hypoventil... περισσότερα »

Detection of Merkel Cell Polyomavirus and Human Papillomavirus in Esophageal Squamous Cell Carcinomas and Non-Cancerous Esophageal Samples in Northern Iran

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 10 δευτερόλεπτα
Detection of Merkel Cell Polyomavirus and Human Papillomavirus in Esophageal Squamous Cell Carcinomas and Non-Cancerous Esophageal Samples in Northern Iran: AbstractHuman papillomavirus (HPV) infection is one of the hypothesized causes of esophageal squamous cell carcinoma (ESCC), but the etiological association remains uncertain. It was postulated that other infectious agents together with HPV may increase the risk of ESCC. The current investigation aimed to explore the presence of a new human tumor virus, Merkel cell polyomavirus (MCPyV), together with HPV in ESCC tumors and non... περισσότερα »

Thymustumoren

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Thymustumoren: Zusammenfassung HintergrundThymustumoren, d. h. Thymome, Thymuskarzinome und -karzinoide, sind mit einer Inzidenz von 0,13/100.000 Einwohnern eine sehr seltene Entität. Material und MethodenAnhand einer Literaturrecherche wurden neuere Erkenntnisse zur Epidemiologie, Klassifikationen und verschiedenen Therapieansätzen recherchiert. ErgebnisseDie sehr verschiedenen Tumoren können lange klinisch inapparent bleiben, die eigentlichen Thymome (A, AB, B1, B2, B3) können Paraneoplasien verursachen, und Thymuskarzinome wachsen sehr aggressiv. Die chirurgische Resekt... περισσότερα »

Ciliary transcription factors in cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Ciliary transcription factors in cancer - How understanding ciliogenesis can promote detection and prognosis of cancer types: Abstract Cilia play a plethora of roles in normal development and homeostasis as well as in disease. Their involvement in cell signaling processes and ability to inhibit cell cycle progression make them especially interesting subjects of investigation in the context of tumor formation and malignancy. Several key transcription factors regulate the transcriptional program in cilia formation and some of these (e.g. RFX factors and FOXJ1) are implicated in cance... περισσότερα »

The classification of frontal sinus pneumatization patterns by CT-based volumetry

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
The classification of frontal sinus pneumatization patterns by CT-based volumetry: Abstract PurposeWe aimed to define the classification of frontal sinus pneumatization patterns according to three-dimensional volume measurements. MethodsDatasets of 148 sides of 74 dry skulls were generated by the computerized tomography-based volumetry to measure frontal sinus volumes. The cutoff points for frontal sinus hypoplasia and hyperplasia were tested by ROC curve analysis and the validity of the diagnostic points was measured. ResultsThe overall frequencies were 4.1, 14.2, 37.2 and... περισσότερα »

The posterior pedicled inferior turbinate–nasoseptal flap: a potential combined flap for skull base reconstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
The posterior pedicled inferior turbinate–nasoseptal flap: a potential combined flap for skull base reconstruction: Abstract ObjectivesTo develop a combined pedicled flap comprising the mucoperiosteum and mucoperichondrium of the inferior turbinate, lateral nasal wall, nasal floor, and nasal septum based on the posterior lateral nasal artery, a branch of the sphenopalatine artery, for the reconstruction of skull base defects resulting from endoscopic expanded endonasal approaches. MethodsEleven fresh adult cadaver heads were dissected. Arterial distribution patterns of the infe... περισσότερα »

Brachial plexus 3D reconstruction from MRI with dissection validation: a baseline study for clinical applications

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Brachial plexus 3D reconstruction from MRI with dissection validation: a baseline study for clinical applications: Abstract PurposeThe present study aimed to establish a baseline for detailed 3D brachial plexus reconstruction from magnetic resonance imaging (MRI). Concretely, the goal was to determine the individual brachial plexus anatomy with maximum detail and accuracy achievable, as yet irrespective of whether the methods used could be economically and practically applied in the clinical setting. Materials and methodsSix embalmed cadavers were randomly taken for MRI imagin... περισσότερα »

Propofol reduces liver dysfunction caused by tumor necrosis factor-α production in Kupffer cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Propofol reduces liver dysfunction caused by tumor necrosis factor-α production in Kupffer cells: Abstract PurposeThe present study, conducted in rats, investigated whether propofol attenuates lipopolysaccharide (LPS)-triggered liver dysfunction via regulation of tumor necrosis factor (TNF)-α production in activated Kupffer cells. MethodsRats received LPS (500 μg/kg) under Urethane™ sedation (1 g/kg) in combination with propofol (5 mg/kg/h) or Intralipid™ from 1 h before to 6 h after LPS administration. Some rats were treated with 10 mg/kg gadolinium chloride (GdCl3) to induce... περισσότερα »

Carbamylated LL-37 as a modulator of the immune response

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Carbamylated LL-37 as a modulator of the immune response: Carbamylation of lysine residues and protein *N*-termini is an ubiquitous, non-enzymatic post-translational modification. Carbamylation at sites of inflammation is due to cyanate formation during the neutrophil oxidative burst and may target lysine residues within the antimicrobial peptide LL-37. The bactericidal and immunomodulatory properties of LL-37 depend on its secondary structure and cationic nature, which are conferred by arginine and lysine residues. Therefore, carbamylation may affect the biological functions of LL... περισσότερα »

Src kinases central to T-cell receptor signaling regulate TLR-activated innate immune responses from human T cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Src kinases central to T-cell receptor signaling regulate TLR-activated innate immune responses from human T cells: TLRs have a fundamental role in immunity. We have recently reported that stimulation of TLR2 and TLR5 in freshly isolated and activated human T cells with microbial ligands without concomitant activation through the TCR brings about secretion of neutrophil chemoattractant, CXCL8, and effector cytokine, IFN-, respectively. However, the mechanism of TLR signaling in T cells has not been worked out. Here, we show that the Src family kinases, p56lck (Lck) and p59fyn (Fyn)... περισσότερα »

Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Follicular regulatory T cells repress cytokine production by follicular helper T cells and optimize IgG responses in mice: Follicular helper T (Tfh) cells provide crucial help to germinal center B (GCB) cells for proper antibody production, and a specialized subset of regulatory T cells, follicular regulatory T (Tfr) cells, modulate this process. However Tfr-cell function in the GC is not well understood. Here, we define Tfr cells as a CD4+ Foxp3+ CXCR5hi PD-1hi CD25low TIGIThigh T-cell population. Furthermore, we have used a novel mouse model (“Bcl6FC”) to delete the Bcl6 gene in ... περισσότερα »

Hereditary angioedema : A novel missense mutation in the C1-inhibitor N-terminal domain

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Hereditary angioedema in a Jordanian family with a novel missense mutation in the C1-inhibitor N-terminal domain via ScienceDirect Publication: Molecular Immunology Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Saied A Jaradat, Sonia Caccia, Rifaat Rawashdeh, Motasem Melhem, Ali Al-Hawamdeh, Thomas Carzaniga, Hazem Haddad Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is an autosomal dominant disease caused by mutations in the SERPING1 gene. A Jordanian family, including 14 individuals with C1-INH-HAE clinical symptoms, was studied.... περισσότερα »

Crescentic flap for the reconstruction of the nose

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
after skin cancer resection via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 16 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): Federica Arginelli, Attilio Carlo Salgarelli, Barbara Ferrari, Amanda Losi, Pierantonio Bellini, Cristina Magnoni PurposeNon-melanoma skin cancers are the most frequent skin tumours; in 25.5% of cases, they are reported to affect the nasal area. For an excellent surgical outcome, first of all the radical excision of the lesion is important, with appropriate margins of healthy sk... περισσότερα »

Hodentorsion: TWIST-Score diagnostisch wegweisend

Schnell und sicher Ob einem akuten Skrotum eine Hodentorsion zugrunde liegt, lässt sich mit dem TWIST-Score schnell und sicher abschätzen. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oJnPge via IFTTT

Fourier-Transform Infrared Absorption Spectroscopy in Binary Hydrocarbon-Alcohol Single Droplet Evaporation

Broadband absorption spectroscopy, by way of FTIR, was used to investigate the vapor cloud of a single millimeter sized liquid droplet suspended by a syringe as it evaporates at standard conditions. Single beam data were collected every 8 seconds resulting in a time-resolved record. Species concentrations were tracked using their resonant absorption peaks and correlated […]

MD Anderson researchers propose new staging for HPV-related oropharyngeal cancer

Current staging system is inadequate; for the first time, research proves that staging based on nasopharyngeal ‘N’ categories offers more predictive value. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PFhUBy via IFTTT

Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis

This study compared the influence of type 2 diabetes on the occurrence of six periodontal pathogens in plaque samples of patients with and without chronic periodontitis. Levels of salivary MMP-8, MMP-9, RANKL, and OPG were also investigated. The study enrolled 31 patients with type 2 diabetes and chronic periodontitis (DM + CP), 29 with chronic […]

Evaluation of Malignancy Grade of Breast Cancer Using Perflubutane-Enhanced Ultrasonography

Publication date: Available online 16 February 2016 Source:Ultrasound in Medicine & Biology Author(s): Norio Masumoto, Takayuki Kadoya, Ai Amioka, Keiko Kajitani, Hideo Shigematsu, Akiko Emi, Kazuo Matsuura, Koji Arihiro, Morihito Okada Whether the contrast effects of perflubutane on contrast-enhanced ultrasonography can predict the malignancy grade of breast cancer is unknown. We analyzed associations between perfusion […]

Technical Challenges in Current PVS Research and Potential Solutions

Publication date: Available online 17 February 2016 Source:Journal of Acupuncture and Meridian Studies Author(s): Kyung Aih Kang, Claudio Maldonado, Vitaly Vodyanoy Since Bonghan Kim’s discovery of the Bonghan System (BHS) in the 1960s, numerous reports have suggested that the system is fundamental for maintaining mammalian life. The BHS is a circulatory system independent of the […]

Compounds of Natural Origin and Acupuncture for the Treatment of Diseases Caused by Estrogen Deficiency

Publication date: Available online 17 February 2016 Source:Journal of Acupuncture and Meridian Studies Author(s): Thakur Abhishek, Mandal C. Subhash, Banerjee Sugato A predominant number of diseases affecting women are related to female hormones. In most of the cases, these diseases are reported to be associated with menstrual problems. These diseases affect female reproductive organs like […]

Sphenoid Wing Meningioma with Extraocular Muscle Involvement Mimicking Idiopathic Orbital Inflammation.

Sphenoid Wing Meningioma with Extraocular Muscle Involvement Mimicking Idiopathic Orbital Inflammation.: Meningiomas are slow growing, typically benign, tumors originating from arachnoid cap cells. Specifically, sphenoid wing or spheno-orbital meningiomas infiltrate the lesser wing of the sphenoid, lateral orbital wall, and orbital roof with occasional extension to the superior orbital fissure, optic canal, anterior clinoid process, […]

Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos

Publication date: Available online 16 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): O. Vella, F. Cuny, L. Robard, C. Bazille IntroductionBenign osteoblastoma is a rare fibrous bone tumour observed in children. Very few cases involving the paranasal sinuses have been reported.SummaryA 10-year-old child presented with a 1-month history of right exophthalmos. […]

Editorial Board – FM1

Publication date: February 2016 Source:Journal of Acupuncture and Meridian Studies, Volume 9, Issue 1 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LtnYcA via IFTTT

Adult Ocular Adnexal Xanthogranulomatous Disease, Erdheim-Chester Disease, and IgG4-Related Disease of the Orbit/Ocular Adnexa.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Comparative Study of Clinical, Pathological, Radiological, and Genetic Features of Patients with Adult Ocular Adnexal Xanthogranulomatous Disease, Erdheim-Chester Disease, and IgG4-Related Disease of the Orbit/Ocular Adnexa.: Purpose: To compare and contrast the clinical, radiologic, pathologic, and genetic features of patients with ocular adnexal IgG4-related disease (IgG4-RD) and patients with adult ocular adnexal xanthogranulomatous disease (XG). Methods: This retrospective review study identified patients with histological evidence of either disease from records of the pathology... περισσότερα »

Upper Eyelid and Pupillary Effects of Topical Dilute Epinephrine.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Upper Eyelid and Pupillary Effects of Topical Dilute Epinephrine.: Purpose: Adrenergic medications may elevate the upper eyelid and dilate the pupil. The effects of topical phenylephrine on Muller's muscle have been well described. Dilute epinephrine (DE) is a sympathomimetic agent commonly administered in blepharoptosis surgery, and has been shown to elevate the upper eyelid margin when injected subcutaneously. The effects of DE applied topically to the eye, whether intentional or inadvertent during surgery have not been characterized. The purpose of this investigation was to quant... περισσότερα »

Powered Endoscopic Dacryocystorhinostomy in Adults Using the Lacrimal Symptom (Lac-Q) Questionnaire.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 18 δευτερόλεπτα
Assessing the Outcomes of Powered Endoscopic Dacryocystorhinostomy in Adults Using the Lacrimal Symptom (Lac-Q) Questionnaire.: Purpose: The objective of this study was to assess the quality of outcomes of powered endoscopic dacryocystorhinostomy using the lacrimal symptom (Lac-Q) questionnaire. Methods: Prospective interventional case series of 50 consecutive patients who underwent primary powered endoscopic dacryocystorhinostomy were included in the study. All the patients had stent placement which were removed at 4 weeks. The Lac-Q questionnaire was administered preoperatively a... περισσότερα »

Omega-3 fatty acids as an adjunct for periodontal therapy—a review

Abstract Objectives The aim of this article is to present an overview of omega-3 fatty acids, their anti-inflammatory properties and potential use as an adjunct for periodontal therapy. Materials and methods A general literature search was conducted to provide an overview of omega-3 fatty acids, their metabolism and anti-inflammatory properties. A more specific literature search […]

Brain Sciences, Vol. 6, Pages 7: Rumination and Rebound from Failure as a Function of Gender and Time on Task

Rumination is a trait response to blocked goals that can have positive or negative outcomes for goal resolution depending on where attention is focused. Whereas “moody brooding” on affective states may be maladaptive, especially for females, “reflective pondering” on concrete strategies for problem solving may be more adaptive. In the context of a challenging general […]

Brain Sciences, Vol. 6, Pages 6: The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS

Normal brain function is highly dependent on oxygen and nutrient supply and when the demand for oxygen exceeds its supply, hypoxia is induced. Acute episodes of hypoxia may cause a depression in synaptic activity in many brain regions, whilst prolonged exposure to hypoxia leads to neuronal cell loss and death. Acute inadequate oxygen supply may […]

Geoff Pfeifer: The New Materialism: Althusser, Badiou, and Žižek

from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QIkPat via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Life-World, Sub-Worlds, After-Worlds: The Various ‘Realnesses’ of Multiple Realities

Abstract This paper will discuss the correlation between the world of everyday life, finite provinces of meaning, and religion. To this end, the paper will start out by explaining Schutz’ considerations on “paramount reality” of the world of everyday life as well as the theory of “multiple realities” and “finite provinces of meaning”. Schutz’ considerations […]

Carotid atherosclerosis, cytomegalovirus infection, and cognitive decline in the very old: a community-based prospective cohort study

Abstract To investigate various risk factors of cognitive decline in the very old, we studied 494 subjects over 85 years old without diagnosis of dementia at baseline from the Tokyo Oldest Old Survey on Total Health, an ongoing, community-based cohort in Japan. Cognitive function was assessed at baseline and at 3-year follow-up using Mini-Mental State […]

Can More Sex Be The Answer For Reduced Throat Cancer Rates? – Latin Post

Latin Post Can More Sex Be The Answer For Reduced Throat Cancer Rates? Latin Post The study, which is published in JAMA Oncology last month, states that HPV-16 is a known cause of neck and throat cancers. When it is found in the oral cavity including the soft palate, tonsils and the tongue, it precedes […]

PVE students graduate from D.A.R.E. – Rapid City Journal

Rapid City Journal PVE students graduate from D.A.R.E. Rapid City Journal Drugs are also intoxicating ad some are even very addictive. For example, cigarettes have something in them that you can get addicted to and can give you sicknesses like lung cancer, heart disease, and tongue cancer. After smoking for a while you teeth … […]

With the men in turmoil, Louisville women’s basketball just keeps rolling – Card Chronicle

Card Chronicle With the men in turmoil, Louisville women’s basketball just keeps rolling Card Chronicle Last year Arica seemed to hang her head the most after a good tongue lashing, and it affected her play. There have been no signs of that her … at home in the Yum! Center at 7pm. The game is […]

Contents Vol. 25, 2015

J Mol Microbiol Biotechnol 2015;25:I-IV from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RMKwvq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Nodular Fasciitis of the Orbit

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Nodular Fasciitis of the Orbit: A Case Report Confirmed by Molecular Cytogenetic Analysis.: Nodular fasciitis is a benign fibroblastic proliferation typically found in the subcutaneous tissue or superficial fascia of the extremities that is often confused for malignancy. These lesions rarely occur on the eyelids and ocular adnexa and are seldom analyzed by ophthalmic pathologists. USP6 gene rearrangement has been recently demonstrated in nodular fasciitis and this rearrangement may lead to the formation of a fusion gene MYH9-USP6 in some cases. Herein, the authors describe a 38-year... περισσότερα »

Eyelid Mycetoma Masquerading as Sebaceous Carcinoma.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Eyelid Mycetoma Masquerading as Sebaceous Carcinoma.: A 56-year-old Asian woman presented with an upper eyelid mass. The lesion was exposed after eversion of the eyelid revealing a thickened tarsus with yellowish areas. Working diagnosis was sebaceous carcinoma. Biopsy was performed. Histopathological studies showed a mycotic eumycetoma with Splendore-Hoeppli phenomena and - microbiologic cultures grew Scedosporium apiospermum. The patient was started on voriconazole 200 mg po bid with adequate serum levels. A complete response was observed after 18 weeks of voriconazole therapy. To... περισσότερα »

Sphenoid Wing Meningioma with Extraocular Muscle Involvement Mimicking Idiopathic Orbital Inflammation.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Sphenoid Wing Meningioma with Extraocular Muscle Involvement Mimicking Idiopathic Orbital Inflammation.: Meningiomas are slow growing, typically benign, tumors originating from arachnoid cap cells. Specifically, sphenoid wing or spheno-orbital meningiomas infiltrate the lesser wing of the sphenoid, lateral orbital wall, and orbital roof with occasional extension to the superior orbital fissure, optic canal, anterior clinoid process, and middle cranial fossa where neurologic and ophthalmologic functions are impaired by compressive injury. The extraocular muscles are rarely involved. ... περισσότερα »

Antimicrobial activity of Butyl acetate, Ethyl acetate and Isopropyl alcohol on undesirable microorganisms in cosmetic products

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Antimicrobial activity of Butyl acetate, Ethyl acetate and Isopropyl alcohol on undesirable microorganisms in cosmetic products: Abstract Objective The microbiological contamination risk of a cosmetic product has to be assessed by the manufacturer, according to the composition, to determine whether microbiological testing is required. Certain ingredients in cosmetic formulations help to create an environment hostile towards microbial growth. In this study, the influence on microbial survival of some solvents used in nail varnisheswas evaluated. The purpose of this study was twofold... περισσότερα »

Association between Bethesda Categories and Ultrasound Features of Conventional Papillary Thyroid Carcinoma

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 28 δευτερόλεπτα
Publication date: Available online 16 February 2016 *Source:*Ultrasound in Medicine & Biology Author(s): Ga Ram Kim, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon The association between categories 3, 5 and 6 of the Bethesda System for Reporting Thyroid Cytopathology and the clinical and ultrasonography (US) features of conventional papillary thyroid carcinoma (PTC) was evaluated. We included 2005 patients diagnosed with conventional PTC at surgery and Bethesda categories 3, 5 and 6 at pre-operative US-guided fine-needle aspiration. Multinomial regression analysis was... περισσότερα »

Giving Children a Voice With Assistive Technology

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 32 δευτερόλεπτα
A child in the public school setting might benefit from various forms of assistive technology (AT). School-based SLPs should work as part of a team with parents, teacher(s) and private SLPs or other clinicians to determine the best use of AT in school as well as external environments like the home. So what is AT?… Continue reading Giving Children a Voice With Assistive Technology

The impact of causal attribution on stigmatizing attitudes toward a person who stutters

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 17 February 2016 *Source:*Journal of Communication Disorders Author(s): Michael P. Boyle PurposeThis study investigated the impact of providing low control (biological) and high control (psychobehavioral) causal explanations for stuttering on a variety of stigma related variables including blame, anger, social distance, stereotypes, dislike, sympathy, willingness to help, and perceptions of potential for recovery for a hypothetical person who stutters.MethodOne hundred and sixty-five university students read one of three vign... περισσότερα »

Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): O. Vella, F. Cuny, L. Robard, C. Bazille IntroductionBenign osteoblastoma is a rare fibrous bone tumour observed in children. Very few cases involving the paranasal sinuses have been reported.SummaryA 10-year-old child presented with a 1-month history of right exophthalmos. Clinical and radiological assessment demonstrated a heterogeneous tumour with bone components occupying all of the maxillary sinus. Initial histology was in favour of fibrous dyspl... περισσότερα »

Pulsatile tinnitus and a temporal bone mass

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D.T. Ginat, M.B. Gluth from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1oJcqgw via IFTTT

A rare cause of exophthalmos in children

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): N. Kolsi, Z. B-Rhaiem, J. Koubaa from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1oJcpJs via IFTTT

Parathyroid carcinoma presenting as mandibular ulceration

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 36 δευτερόλεπτα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Oukessou, M. Ait El Kerdoudi, H. El Attar, M. Mahtar from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/218khlr via IFTTT

Technical Challenges in Current PVS Research and Potential Solutions

Publication date: Available online 17 February 2016 Source:Journal of Acupuncture and Meridian Studies Author(s): Kyung Aih Kang, Claudio Maldonado, Vitaly Vodyanoy Since Bonghan Kim’s discovery of the Bonghan System (BHS) in the 1960s, numerous reports have suggested that the system is fundamental for maintaining mammalian life. The BHS is a circulatory system independent of the […]

Compounds of Natural Origin and Acupuncture for the Treatment of Diseases Caused by Estrogen Deficiency

Publication date: Available online 17 February 2016 Source:Journal of Acupuncture and Meridian Studies Author(s): Thakur Abhishek, Mandal C. Subhash, Banerjee Sugato A predominant number of diseases affecting women are related to female hormones. In most of the cases, these diseases are reported to be associated with menstrual problems. These diseases affect female reproductive organs like […]

Editorial Board – FM1

Publication date: February 2016 Source:Journal of Acupuncture and Meridian Studies, Volume 9, Issue 1 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LtnYcA via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Amblyopia: Can Laser Acupuncture Be an Option?

Publication date: Available online 17 February 2016 Source:Journal of Acupuncture and Meridian Studies Author(s): Marzio Vanzini, Michele Gallamini This paper describes the results of the treatment of amblyopia in young patients by using an unconventional laser-acupuncture technique. After satisfactory results had been obtained in the treatment of a 14-year-old amblyopic girl, the treatment was applied […]

International Scientific Acupuncture and Meridian Symposium 2015

Publication date: February 2016 Source:Journal of Acupuncture and Meridian Studies, Volume 9, Issue 1 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SxWt9i via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Recommended Articles

Publication date: February 2016 Source:Journal of Acupuncture and Meridian Studies, Volume 9, Issue 1 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LtnVNO via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Recommended Articles

Publication date: February 2016 Source:Journal of Acupuncture and Meridian Studies, Volume 9, Issue 1 from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SxWsCj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Brain Sciences, Vol. 6, Pages 7: Rumination and Rebound from Failure as a Function of Gender and Time on Task

Rumination is a trait response to blocked goals that can have positive or negative outcomes for goal resolution depending on where attention is focused. Whereas “moody brooding” on affective states may be maladaptive, especially for females, “reflective pondering” on concrete strategies for problem solving may be more adaptive. In the context of a challenging general […]

Brain Sciences, Vol. 6, Pages 6: The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS

Normal brain function is highly dependent on oxygen and nutrient supply and when the demand for oxygen exceeds its supply, hypoxia is induced. Acute episodes of hypoxia may cause a depression in synaptic activity in many brain regions, whilst prolonged exposure to hypoxia leads to neuronal cell loss and death. Acute inadequate oxygen supply may […]

Pattern identification of biomedical images with time series: Contrasting THz pulse imaging with DCE-MRIs

Publication date: Available online 16 February 2016 Source:Artificial Intelligence in Medicine Author(s): Xiao-Xia Yin, Sillas Hadjiloucas, Yanchun Zhang, Min-Ying Su, Yuan Miao, Derek Abbott ObjectiveWe provide a survey of recent advances in biomedical image analysis and classification from emergent imaging modalities such as terahertz (THz) pulse imaging (TPI) and dynamic contrast-enhanced magnetic resonance images (DCE-MRIs) […]

T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA+CD62L+), central memory (CM, CD45RA−CD62L+), effector memory (EM, CD45RA−CD62L−), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA+CD62L−) in 25 persons with biological and 7 with mechanical prosthesis compared with 48 apparently healthy volunteers. The relative and absolute number o... περισσότερα »

Diode endovascular laser treatment in venous malformations of the upper aerodigestive tract

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Diode endovascular laser treatment in venous malformations of the upper aerodigestive tract via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 15 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): François Simon, Nicolas Le Clerc, Didier Salvan, Elisabeth Sauvaget, Benoît Faucon, Michel Borsik, Philippe Herman, Annouk Bisdorff PurposeVenous malformations of the upper aerodigestive tract can cause pain, dysphagia, obstructive sleep apnea, and rarely bleeding. We studied 980-nm diode endovenous laser therapy.Ma... περισσότερα »

Oral diseases in pediatric HIV-infected populations

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
The global burden of oral diseases in pediatric HIV-infected populations: a workshop report: Objectives To achieve a comprehensive understanding about the global burden of oral diseases in HIV-infected children and to identify research needs. Materials and methods A literature search was conducted in PubMed (2009–2014) to address five questions: (i) prevalence of oral diseases in HIV-infected compared with uninfected children, (ii) impact of oral diseases on quality of life, (iii) effect of antiretroviral exposure *in utero* on craniofacial and dental development, (iv) important co... περισσότερα »

Human papilloma virus and other biologic markers in nasopharyngeal cancer

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Clinical implications of human papilloma virus and other biologic markers in nasopharyngeal cancer: Human papilloma virus (HPV) is associated with both the occurrence and prognosis of oropharyngeal cancer. However, few studies have examined the relationship between HPV and nasopharyngeal cancer (NPC). This study investigated the clinical implications of HPV and other molecular markers, including p16, p53, and epidermal growth factor receptor (EGFR), for NPC patients. from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/249U8VP via IFTTT

Infraorbital necrotising fasciitis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Infraorbital necrotising fasciitis: importance of rehabilitation in vulnerable patients: A 31-year-old woman presented to the accident and emergency department after a blunt force injury to the right side of her face from an alleged assault. She had mental health problems and a history of substance misuse. There was periorbital swelling, but all investigations were within normal limits. The next day her right eye swelled with pus and she had signs of acute sepsis (Fig. 1). She was diagnosed with necrotising fasciitis by the maxillofacial team, and immediately taken to the operating ... περισσότερα »

Natural position of the head

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
: review of two-dimensional and three-dimensional methods of recording via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 16 February 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): D. Cassi, C. De Biase, I. Tonni, M. Gandolfini, A. Di Blasio, M.G. Piancino Both the correct position of the patient's head and a standard system for the acquisition of images are essential for objective evaluation of the facial profile and the skull, and for longitudinal superimposition. The natural position of the head was introduced into or... περισσότερα »

Reaction of glass ionomer cements

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Evidence of a complex species controlling the setting reaction of glass ionomer cements via Dental Materials Publication date: Available online 15 February 2016 *Source:*Dental Materials Author(s): Brett Dickey, Richard Price, Daniel Boyd ObjectiveTo elucidate the mechanism(s) responsible for the profound impact germanium has on the setting reaction of zinc silicate glass ionomer cements (GICs).MethodsFive <45μm glass powder compositions (0.48-xSiO2, xGeO2, 0.36 ZnO, 0.16 CaO; where x=0.12, 0.24, 0.36, 0.48mol. fraction) were synthesized. Glass degradation was assessed under simulated... περισσότερα »

Systemic T Cells and Monocyte Characteristics in Patients with Denture Stomatitis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Systemic T Cells and Monocyte Characteristics in Patients with Denture Stomatitis: Abstract Purpose Chronic inflammatory disorders of the oral cavity, such as periodontitis, were recently linked to systemic immune activation. Since fungal oral infections have not yet been studied in this respect, the aim of our study is to determine whether the local inflammation caused by oral fungal infection of the palatal tissue (denture stomatitis—DS) is associated with the systemic inflammatory response. This question is becoming essential as the population ages. Materials and Methods Perip... περισσότερα »

Age-Related Changes in Binaural Interaction at Brainstem Level.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Age-Related Changes in Binaural Interaction at Brainstem Level.: Objectives: Age-related hearing loss hampers the ability to understand speech in adverse listening conditions. This is attributed to a complex interaction of changes in the peripheral and central auditory system. One aspect that may deteriorate across the lifespan is binaural interaction. The present study investigates binaural interaction at the level of the auditory brainstem. It is hypothesized that brainstem binaural interaction deteriorates with advancing age. Design: Forty-two subjects of various age participated... περισσότερα »

Impact of Hearing Aid Technology on Outcomes in Daily Life I: The Patients' Perspective.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Impact of Hearing Aid Technology on Outcomes in Daily Life I: The Patients' Perspective.: Objectives: One of the challenges facing hearing care providers when recommending hearing aids is the choice of device technology level. Major manufacturers market families of hearing aids that are described as spanning the range from basic technology to premium technology. Premium technology hearing aids include acoustical processing capabilities (features) that are not found in basic technology instruments. These premium features are intended to yield improved hearing in daily life compared w... περισσότερα »

Auditory Impairments in HIV-Infected Children.

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Auditory Impairments in HIV-Infected Children.: Objectives: In a cross-sectional study of human immunodeficiency virus (HIV)-infected adults, the authors showed lower distortion product otoacoustic emissions (DPOAEs) in HIV+ individuals compared with controls as well as findings consistent with a central auditory processing deficit in HIV+ adults on antiretroviral therapy. The authors hypothesized that HIV+ children would also have a higher prevalence of abnormal central and peripheral hearing test results compared with HIV- controls. Design: Pure-tone thresholds, DPOAEs, and tympan... περισσότερα »

Nasal function and dysfunction in exercise

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Review Article Nasal function and dysfunction in exercise A Walkera1 c1, P Surdaa1, M Rossitera2 and S Littlea1 a1 Department of ENT Surgery, St George's Hospital, London, UK a2 All Sports Medicine, Candover Clinic, Basingstoke and North Hampshire Hospital, Basingstoke, UK Abstract Background: There have been recent advances in our appreciation of the functional complementarity of the upper and lower airways. The unified airway begins at the nose: rather than acting merely as a conduit for air to the lungs, the nose and nasal cavity perform an important role in filtering, humidificat... περισσότερα »

Contents Vol. 25, 2015

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
J Mol Microbiol Biotechnol 2015;25:I-IV from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RMKwvq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mH8dZ0 via IFTTT

Active middle-ear implant fixation in an unusual place

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Clinical Record Active middle-ear implant fixation in an unusual place: clinical and audiological outcomes J F Polanskia1a2 c1, A D Soaresa1, Z M Dos Santosa1 and O L Mendonça Cruza1 a1 Department of Otolaryngology and Head and Neck Surgery, Federal University of São Paulo ('UNIFESP'), Curitiba, Brazil a2 Department of Otorhinolaryngology, Federal University of Parana, Curitiba, Brazil Abstract Objective: The Vibrant Soundbridge is an active middle-ear implant for hearing rehabilitation that is usually placed in the long process of the incus or round window. This study reports on th... περισσότερα »

Chemotherapy Modulates Intestinal Immune Gene Expression Including Surfactant Protein-D and Deleted in Malignant Brain Tumors 1 in Piglets

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
*Background:* Information about chemotherapy-induced intestinal gene expression may provide insight into the mechanisms underlying gut toxicity and help identify biomarkers and targets for intervention. *Methods:* We analyzed jejunal tissue from piglets subjected to two different, clinically relevant chemotherapy regimens: (1) busulfan plus cyclophosphamide (BUCY) and (2) doxorubicin (DOX). *Results:* Gene expression analysis identified 1,328 differentially expressed genes in the BUCY piglets and 594 in the DOX piglets, compared to controls. Similar changes in expression were found... περισσότερα »

A case of pharyngeal diphtheria in Germany, June 2015

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Abstract Background In June 2015, a 45-year-old man suffering from acute necrotic tonsillitis and throat phlegmon was hospitalized in Nuremberg, Germany. After emergency surgery the patient was initially treated with antibiotics. Results A throat swab grew a toxigenic *Corynebacterium diphtheriae* biovar mitis strain. The patient's vaccination status was not documented and the patient was tested serologically for anti-diphtheria antibodies showing no protective immunity. Extensive control investigations were performed by the local health department showing no likely source of his ... περισσότερα »

A Combination of Targeted Therapy with Chemotherapy Backbone Induces Response in a Treatment-Resistant Triple-Negative MCL1-Amplified Metastatic Breast Cancer Patient

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
After failure of anthracycline- and platinum-based therapy, no effective therapies exist for management of metastatic triple-negative breast cancer (TNBC). We report a case of metastatic TNBC harboring MCL1 amplification, as identified by comprehensive genomic profiling in the course of clinical care. *MCL1* is an antiapoptotic gene in the BCL2 family, and *MCL1* amplification is common in TNBC (at least 20%). A personalized dose-reduced regimen centered on a combination of sorafenib and vorinostat was implemented, based on preclinical evidence demonstrating treatment synergy in t... περισσότερα »

Parathyroid carcinoma presenting as mandibular ulceration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Parathyroid carcinoma presenting as mandibular ulceration via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 16 February 2016 [image: CT scan, coronal (A) and axial (B) section showing a neck mass displacing the ...] [image: Histological appearance of parathyroid carcinoma with the presence of vascular ...] *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Oukessou, M. Ait El Kerdoudi, H. El Attar, M. Mahtar from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http:/... περισσότερα »

Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): O. Vella, F. Cuny, L. Robard, C. Bazille IntroductionBenign osteoblastoma is a rare fibrous bone tumour observed in children. Very few cases involving the paranasal sinuses have been reported.SummaryA 10-year-old child presented with a 1-month history of right exophthalmos. Clinical and radiological assessment demonstrated a heterogeneous tumour with bone components occupying all of the maxillary sinus. Initial histology was in favour of fibrous dyspl... περισσότερα »

Sphenoid Wing Meningioma with Extraocular Muscle Involvement Mimicking Idiopathic Orbital Inflammation.

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 51 δευτερόλεπτα
Meningiomas are slow growing, typically benign, tumors originating from arachnoid cap cells. Specifically, sphenoid wing or spheno-orbital meningiomas infiltrate the lesser wing of the sphenoid, lateral orbital wall, and orbital roof with occasional extension to the superior orbital fissure, optic canal, anterior clinoid process, and middle cranial fossa where neurologic and ophthalmologic functions are impaired by compressive injury. The extraocular muscles are rarely involved. The authors present a rare case of an spheno-orbital meningioma causing extraocular muscle enlargement mi... περισσότερα »

Eyelid Mycetoma Masquerading as Sebaceous Carcinoma.

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 51 δευτερόλεπτα
A 56-year-old Asian woman presented with an upper eyelid mass. The lesion was exposed after eversion of the eyelid revealing a thickened tarsus with yellowish areas. Working diagnosis was sebaceous carcinoma. Biopsy was performed. Histopathological studies showed a mycotic eumycetoma with Splendore-Hoeppli phenomena and - microbiologic cultures grew Scedosporium apiospermum. The patient was started on voriconazole 200 mg po bid with adequate serum levels. A complete response was observed after 18 weeks of voriconazole therapy. To the best of our knowledge, this is the first publishe... περισσότερα »

Nodular Fasciitis of the Orbit: A Case Report Confirmed by Molecular Cytogenetic Analysis.

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 51 δευτερόλεπτα
Nodular fasciitis is a benign fibroblastic proliferation typically found in the subcutaneous tissue or superficial fascia of the extremities that is often confused for malignancy. These lesions rarely occur on the eyelids and ocular adnexa and are seldom analyzed by ophthalmic pathologists. USP6 gene rearrangement has been recently demonstrated in nodular fasciitis and this rearrangement may lead to the formation of a fusion gene MYH9-USP6 in some cases. Herein, the authors describe a 38-year-old woman with a 6-month history of a progressively enlarging mass beneath her right medial ... περισσότερα »

Assessing the Outcomes of Powered Endoscopic Dacryocystorhinostomy in Adults Using the Lacrimal Symptom (Lac-Q) Questionnaire.

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 51 δευτερόλεπτα
Purpose: The objective of this study was to assess the quality of outcomes of powered endoscopic dacryocystorhinostomy using the lacrimal symptom (Lac-Q) questionnaire. Methods: Prospective interventional case series of 50 consecutive patients who underwent primary powered endoscopic dacryocystorhinostomy were included in the study. All the patients had stent placement which were removed at 4 weeks. The Lac-Q questionnaire was administered preoperatively and at 4 weeks and 16 weeks following the surgery. Outcomes assessed were anatomical success, functional success, and changes in t... περισσότερα »

Upper Eyelid and Pupillary Effects of Topical Dilute Epinephrine.

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 51 δευτερόλεπτα
Purpose: Adrenergic medications may elevate the upper eyelid and dilate the pupil. The effects of topical phenylephrine on Muller's muscle have been well described. Dilute epinephrine (DE) is a sympathomimetic agent commonly administered in blepharoptosis surgery, and has been shown to elevate the upper eyelid margin when injected subcutaneously. The effects of DE applied topically to the eye, whether intentional or inadvertent during surgery have not been characterized. The purpose of this investigation was to quantify and compare the effects of topical DE and phenylephrine on upper... περισσότερα »

Comparative Study of Clinical, Pathological, Radiological, and Genetic Features of Patients with Adult Ocular Adnexal Xanthogranulomatous Disease, Erdheim-Chester Disease, and IgG4-Related Disease of the Orbit/Ocular Adnexa.

Alexandros G. SfakianakisστοΚοσμητική και Επανορθωτική ΧειρουργικήΠριν από 51 δευτερόλεπτα
Purpose: To compare and contrast the clinical, radiologic, pathologic, and genetic features of patients with ocular adnexal IgG4-related disease (IgG4-RD) and patients with adult ocular adnexal xanthogranulomatous disease (XG). Methods: This retrospective review study identified patients with histological evidence of either disease from records of the pathology department of our hospital from 1996 to 2014. Clinical, imaging, and a variety of histopathologic features were collected for 23 patients with IgG4-RD and 13 patients with XG. Next generation sequencing with a 50-gene cancer ... περισσότερα »

Effects of 36.6 GHz and static magnetic field on degree of endoreduplication in Drosophila melanogaster polytene chromosomes

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 51 δευτερόλεπτα
10.3109/09553002.2016.1137105<br>Liliia D. Dyka from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1mH09Yi via IFTTT

Exposure to electromagnetic field attenuates oxygen-glucose deprivation-induced microglial cell death by reducing intracellular Ca2+ and ROS

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 51 δευτερόλεπτα
10.3109/09553002.2016.1136851<br>Cao Nguyen Duong from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1mH09Y8 via IFTTT

Recruitment of Immune Cells into Inflamed Tissues: Consequences for Endothelial Barrier Integrity and Tissue Functionality

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 54 δευτερόλεπτα
from Infection via ola Kala on Inoreader http://ift.tt/1QkM40t via IFTTT

T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 54 δευτερόλεπτα
The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA+CD62L+), central memory (CM, CD45RA−CD62L+), effector memory (EM, CD45RA−CD62L−), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA+CD62L−) in 25 persons with biological and 7 with mechanical prosthesis compared with 48 apparently healthy volunteers. The relative and absolute number o... περισσότερα »

Ηλεκτρισμός εγκεφάλου – Επιληψία

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 1 ώρα
Ο εγκέφαλος διαθέτει, όσο οι νευρώνες του είναι ζωντανοί, ένα ηλεκτρικό φορτίο που κυκλοφορεί με τη «μορφή» βιοηλεκτρικού ρεύματος. Σε φυσιολογικές καταστάσεις ζωής, το ηλεκτρικό ρεύμα αυτό φροντίζει όχι μόνο για την ήρεμη λειτουργία του εγκεφάλου αλλά και τη διατήρηση της ύπαρξής του. Τοπικές ή γενικευμένες διαταραχές του βιοηλεκτρικού αυτού ρεύματος, προκαλούν άμεσα λειτουργικές διαταραχές […] [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=RTn83K72VgA:Jo_0A6cMTn0:gIN9vFwOq] from Neurology via xlomafota13 on Inoreader http://ift.tt/1U7n5NL via IFTTT

Diode endovascular laser treatment in venous malformations of the upper aerodigestive tract

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Diode endovascular laser treatment in venous malformations of the upper aerodigestive tract via ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery Publication date: Available online 15 February 2016 *Source:*Journal of Cranio-Maxillofacial Surgery Author(s): François Simon, Nicolas Le Clerc, Didier Salvan, Elisabeth Sauvaget, Benoît Faucon, Michel Borsik, Philippe Herman, Annouk Bisdorff PurposeVenous malformations of the upper aerodigestive tract can cause pain, dysphagia, obstructive sleep apnea, and rarely bleeding. We studied 980-nm diode endovenous laser therapy.Mat... περισσότερα »

Oral diseases in pediatric HIV-infected populations

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
The global burden of oral diseases in pediatric HIV-infected populations: a workshop report: Objectives To achieve a comprehensive understanding about the global burden of oral diseases in HIV-infected children and to identify research needs. Materials and methods A literature search was conducted in PubMed (2009–2014) to address five questions: (i) prevalence of oral diseases in HIV-infected compared with uninfected children, (ii) impact of oral diseases on quality of life, (iii) effect of antiretroviral exposure *in utero* on craniofacial and dental development, (iv) important co-... περισσότερα »

Human papilloma virus and other biologic markers in nasopharyngeal cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Clinical implications of human papilloma virus and other biologic markers in nasopharyngeal cancer: Human papilloma virus (HPV) is associated with both the occurrence and prognosis of oropharyngeal cancer. However, few studies have examined the relationship between HPV and nasopharyngeal cancer (NPC). This study investigated the clinical implications of HPV and other molecular markers, including p16, p53, and epidermal growth factor receptor (EGFR), for NPC patients.

Infraorbital necrotising fasciitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Infraorbital necrotising fasciitis: importance of rehabilitation in vulnerable patients: A 31-year-old woman presented to the accident and emergency department after a blunt force injury to the right side of her face from an alleged assault. She had mental health problems and a history of substance misuse. There was periorbital swelling, but all investigations were within normal limits. The next day her right eye swelled with pus and she had signs of acute sepsis (Fig. 1). She was diagnosed with necrotising fasciitis by the maxillofacial team, and immediately taken to the operating ... περισσότερα »

Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): O. Vella, F. Cuny, L. Robard, C. Bazille IntroductionBenign osteoblastoma is a rare fibrous bone tumour observed in children. Very few cases involving the paranasal sinuses have been reported.SummaryA 10-year-old child presented with a 1-month history of right exophthalmos. Clinical and radiological assessment demonstrated a heterogeneous tumour with bone components occupying all of the maxillary sinus. Initial histology was in favour of fibrous dyspl... περισσότερα »

Pulsatile tinnitus and a temporal bone mass

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D.T. Ginat, M.B. Gluth from #ORL via xlomafota13 on Inoreader http://ift.tt/1oJcqgw via IFTTT

Natural position of the head

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
: review of two-dimensional and three-dimensional methods of recording via British Journal of Oral and Maxillofacial Surgery Publication date: Available online 16 February 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): D. Cassi, C. De Biase, I. Tonni, M. Gandolfini, A. Di Blasio, M.G. Piancino Both the correct position of the patient's head and a standard system for the acquisition of images are essential for objective evaluation of the facial profile and the skull, and for longitudinal superimposition. The natural position of the head was introduced into ort... περισσότερα »

Reaction of glass ionomer cements

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Evidence of a complex species controlling the setting reaction of glass ionomer cements via Dental Materials Publication date: Available online 15 February 2016 *Source:*Dental Materials Author(s): Brett Dickey, Richard Price, Daniel Boyd ObjectiveTo elucidate the mechanism(s) responsible for the profound impact germanium has on the setting reaction of zinc silicate glass ionomer cements (GICs).MethodsFive &lt;45μm glass powder compositions (0.48-xSiO2, xGeO2, 0.36 ZnO, 0.16 CaO; where x=0.12, 0.24, 0.36, 0.48mol. fraction) were synthesized. Glass degradation was assessed under simulated ... περισσότερα »

Systemic T Cells and Monocyte Characteristics in Patients with Denture Stomatitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Systemic T Cells and Monocyte Characteristics in Patients with Denture Stomatitis: Abstract Purpose Chronic inflammatory disorders of the oral cavity, such as periodontitis, were recently linked to systemic immune activation. Since fungal oral infections have not yet been studied in this respect, the aim of our study is to determine whether the local inflammation caused by oral fungal infection of the palatal tissue (denture stomatitis—DS) is associated with the systemic inflammatory response. This question is becoming essential as the population ages. Materials and Methods Periphe... περισσότερα »

Age-Related Changes in Binaural Interaction at Brainstem Level.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Age-Related Changes in Binaural Interaction at Brainstem Level.: Objectives: Age-related hearing loss hampers the ability to understand speech in adverse listening conditions. This is attributed to a complex interaction of changes in the peripheral and central auditory system. One aspect that may deteriorate across the lifespan is binaural interaction. The present study investigates binaural interaction at the level of the auditory brainstem. It is hypothesized that brainstem binaural interaction deteriorates with advancing age. Design: Forty-two subjects of various age participated... περισσότερα »

Impact of Hearing Aid Technology on Outcomes in Daily Life I: The Patients' Perspective.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Impact of Hearing Aid Technology on Outcomes in Daily Life I: The Patients' Perspective.: Objectives: One of the challenges facing hearing care providers when recommending hearing aids is the choice of device technology level. Major manufacturers market families of hearing aids that are described as spanning the range from basic technology to premium technology. Premium technology hearing aids include acoustical processing capabilities (features) that are not found in basic technology instruments. These premium features are intended to yield improved hearing in daily life compared w... περισσότερα »

Auditory Impairments in HIV-Infected Children.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Auditory Impairments in HIV-Infected Children.: Objectives: In a cross-sectional study of human immunodeficiency virus (HIV)-infected adults, the authors showed lower distortion product otoacoustic emissions (DPOAEs) in HIV+ individuals compared with controls as well as findings consistent with a central auditory processing deficit in HIV+ adults on antiretroviral therapy. The authors hypothesized that HIV+ children would also have a higher prevalence of abnormal central and peripheral hearing test results compared with HIV- controls. Design: Pure-tone thresholds, DPOAEs, and tympan... περισσότερα »

Nasal function and dysfunction in exercise

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Review ArticleNasal function and dysfunction in exerciseA Walkera1 c1, P Surdaa1, M Rossitera2 and S Littlea1 a1 Department of ENT Surgery, St George's Hospital, London, UK a2 All Sports Medicine, Candover Clinic, Basingstoke and North Hampshire Hospital, Basingstoke, UK Abstract Background: There have been recent advances in our appreciation of the functional complementarity of the upper and lower airways. The unified airway begins at the nose: rather than acting merely as a conduit for air to the lungs, the nose and nasal cavity perform an important role in filtering, humidification... περισσότερα »

Active middle-ear implant fixation in an unusual place

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Clinical RecordActive middle-ear implant fixation in an unusual place: clinical and audiological outcomesJ F Polanskia1a2 c1, A D Soaresa1, Z M Dos Santosa1 and O L Mendonça Cruza1 a1 Department of Otolaryngology and Head and Neck Surgery, Federal University of São Paulo (‘UNIFESP’), Curitiba, Brazil a2 Department of Otorhinolaryngology, Federal University of Parana, Curitiba, Brazil Abstract Objective: The Vibrant Soundbridge is an active middle-ear implant for hearing rehabilitation that is usually placed in the long process of the incus or round window. This study reports on the un... περισσότερα »

A rare cause of exophthalmos in children

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): N. Kolsi, Z. B-Rhaiem, J. Koubaa from #ORL via xlomafota13 on Inoreader http://ift.tt/1oJcpJs via IFTTT

Parathyroid carcinoma presenting as mandibular ulceration

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Oukessou, M. Ait El Kerdoudi, H. El Attar, M. Mahtar from #ORL via xlomafota13 on Inoreader http://ift.tt/218khlr via IFTTT

The impact of causal attribution on stigmatizing attitudes toward a person who stutters

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: Available online 17 February 2016 *Source:*Journal of Communication Disorders Author(s): Michael P. Boyle PurposeThis study investigated the impact of providing low control (biological) and high control (psychobehavioral) causal explanations for stuttering on a variety of stigma related variables including blame, anger, social distance, stereotypes, dislike, sympathy, willingness to help, and perceptions of potential for recovery for a hypothetical person who stutters.MethodOne hundred and sixty-five university students read one of three vign... περισσότερα »

Parathyroid carcinoma presenting as mandibular ulceration

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Parathyroid carcinoma presenting as mandibular ulceration via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 16 February 2016 [image: CT scan, coronal (A) and axial (B) section showing a neck mass displacing the ...] [image: Histological appearance of parathyroid carcinoma with the presence of vascular ...] *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Oukessou, M. Ait El Kerdoudi, H. El Attar, M. Mahtar

Pulsatile tinnitus and a temporal bone mass

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Pulsatile tinnitus and a temporal bone mass via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D.T. Ginat, M.B. Gluth [image: a: axial CT image shows an expansile lytic lesion involving the left temporal ...]

A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Background. Extrarenal retroperitoneal angiomyolipomas are rare. Aim. To review the literature. Results. Angiomyolipomas, previously classified as hamartomas, are now classified as benign tumours. Thirty cases of primary retroperitoneal angiomyolipomas have been reported. Diagnosis of the disease upon is based radiological and pathological findings of triphasic features of (a) fat and (b) blood vessels and myoid tissue. Immunohistochemistry tends to be positive for HMB45, MART1, HHF35, calponin, NKI-C3, and CD117. The lesion is common in women. Treatment options have included the ... περισσότερα »

Salicylate-Induced Hearing Loss Trigger Structural Synaptic Modifications in the Ventral Cochlear Nucleus of Rats via Medial Olivocochlear (MOC) Feedback Circuit

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Lesion-induced cochlear damage can result in synaptic outgrowth in the ventral cochlear nucleus (VCN). Tinnitus may be associated with the synaptic outgrowth and hyperactivity in the VCN. However, it remains unclear how hearing loss triggers structural synaptic modifications in the VCN of rats subjected to salicylate-induced tinnitus. To address this issue, we evaluated tinnitus-like behavior in rats after salicylate treatment and compared the amplitude of the distortion product evoked otoacoustic emission (DPOAE) and auditory brainstem response (ABR) between control and ... περισσότερα »

Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer’s Disease-Diabetes Dual Therapy

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract At the present time, treatment of two most common degenerative disorders of elderly population i.e., Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD) is a major concern worldwide. As there are several evidences that proved strong linkages between these two disorders, the idea of using dual therapeutic agent for both the diseases might be considered as a good initiative. Earlier reports have revealed that oral anti-diabetic drugs such as peroxisome proliferator activated receptor γ (PPARγ) agonists (thiazolidinediones) when used in T2DM patients suffering from A... περισσότερα »

Production and Characterization of Polyhydroxyalkanoates and Native Microorganisms Synthesized from Fatty Waste

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Polyhydroxyalkanoates (PHAs) are biodegradable and biocompatible plastics. They are synthesized by a wide variety of microorganisms (i.e., fungi and bacteria) and some organisms such as plants, which share characteristics with petrochemical-based plastics. The most recent studies focus on finding inexpensive substrates and extraction strategies that allow reducing product costs, thus moving into a widespread market, the market for petroleum-based plastics. In this study, the production of polyhydroxybutyrate (PHB) was evaluated using the native strains, Bacillus megaterium, Bacill... περισσότερα »

Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): O. Vella, F. Cuny, L. Robard, C. Bazille IntroductionBenign osteoblastoma is a rare fibrous bone tumour observed in children. Very few cases involving the paranasal sinuses have been reported.SummaryA 10-year-old child presented with a 1-month history of right exophthalmos. Clinical and radiological assessment demonstrated a heterogeneous tumour with bone components occupying all of the maxillary sinus. Initial histology was in favour of fibrous dyspl... περισσότερα »

Fourier-Transform Infrared Absorption Spectroscopy in Binary Hydrocarbon-Alcohol Single Droplet Evaporation

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Broadband absorption spectroscopy, by way of FTIR, was used to investigate the vapor cloud of a single millimeter sized liquid droplet suspended by a syringe as it evaporates at standard conditions. Single beam data were collected every 8 seconds resulting in a time-resolved record. Species concentrations were tracked using their resonant absorption peaks and correlated with a multidimensional numerical model. The numerical model combined a Gaussian beam transmission through a temporally changing spherical vapor cloud with radial concentration gradients, informed by the law and in... περισσότερα »

T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA+CD62L+), central memory (CM, CD45RA−CD62L+), effector memory (EM, CD45RA−CD62L−), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA+CD62L−) in 25 persons with biological and 7 with mechanical prosthesis compared with 48 apparently healthy volunteers. The relative and absolute number o... περισσότερα »

Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Trophic factor treatment has been shown to improve the recovery of brain and spinal cord injury (SCI). In this study, we examined the effects of TSC1 (a combination of insulin-like growth factor 1 and transferrin) 4 and 8 h after SCI at the thoracic segment level (T12) in nestin-GFP transgenic mice. TSC1 treatment for 4 and 8 h increased the number of nestin-expressing cells around the lesion site and prevented Wallerian degeneration. Treatment with TSC1 for 4 h significantly increased heat shock protein (HSP)-32 and HSP-70 expression 1 and 2 mm from lesion site (both, ca... περισσότερα »

Benington schoolboy flies to the USA for specialist cancer treatment – Hertfordshire Mercury

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
*Benington schoolboy flies to the USA for specialist cancer treatment* *Hertfordshire Mercury* Brave schoolboy Benjamin Carter has flown out to the United States for a specialist *cancer* treatment not available in the UK. The 11-year-old, of Walkern Road, Benington, suffers from rhabdomyosarcoma (RMS), which affects the muscle tissue in his *larynx*. from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1QlkuKr via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LtlbA2 via IFTTT from #Med Blogs ... περισσότερα »

Pharmaceutics, Vol. 8, Pages 4: Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Cytochrome P450 drug metabolizing enzymes are implicated in personalized medicine for two main reasons. First, inter-individual variability in CYP3A4 expression is a confounding factor during cancer treatment. Second, inhibition or induction of CYP3A4 can trigger adverse drug–drug interactions. However, inflammation can downregulate CYP3A4 and other drug metabolizing enzymes and lead to altered metabolism of drugs and essential vitamins and lipids. Little is known about effects of inflammation on expression of CYP450 genes controlling drug metabolism in the skin. Therefore, we ana... περισσότερα »

Evaluation of Malignancy Grade of Breast Cancer Using Perflubutane-Enhanced Ultrasonography

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*Ultrasound in Medicine &amp; Biology Author(s): Norio Masumoto, Takayuki Kadoya, Ai Amioka, Keiko Kajitani, Hideo Shigematsu, Akiko Emi, Kazuo Matsuura, Koji Arihiro, Morihito Okada Whether the contrast effects of perflubutane on contrast-enhanced ultrasonography can predict the malignancy grade of breast cancer is unknown. We analyzed associations between perfusion parameters created from time–intensity curves based on enhancement intensity and temporal changes in contrast-enhanced ultrasonography and clinicopathologic factors... περισσότερα »

Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
This study compared the influence of type 2 diabetes on the occurrence of six periodontal pathogens in plaque samples of patients with and without chronic periodontitis. Levels of salivary MMP-8, MMP-9, RANKL, and OPG were also investigated. The study enrolled 31 patients with type 2 diabetes and chronic periodontitis (DM + CP), 29 with chronic periodontitis (CP), and 20 with type 2 diabetes (DM). Questionnaire-guided interviews were conducted and plaque index, bleeding on probing, and pocket depth were recorded. Polymerase chain reaction (PCR) was utilized to determine the prevale... περισσότερα »

Pulsatile tinnitus and a temporal bone mass

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D.T. Ginat, M.B. Gluth from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oJcqgw via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LtlHOx via IFTTT

Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): O. Vella, F. Cuny, L. Robard, C. Bazille IntroductionBenign osteoblastoma is a rare fibrous bone tumour observed in children. Very few cases involving the paranasal sinuses have been reported.SummaryA 10-year-old child presented with a 1-month history of right exophthalmos. Clinical and radiological assessment demonstrated a heterogeneous tumour with bone components occupying all of the maxillary sinus. Initial histology was in favour of fibrous dyspl... περισσότερα »

ESUS: Fire and forget? So einfach ist das nicht

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Kryptogener Insult Bis zu zwei Drittel der Patienten mit kryptogenem Schlaganfall entwickeln ein Vorhofflimmern – wenn man nur lange genug danach sucht. Sollte man die Suche also nicht besser lassen und gleich antikoagulieren? from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/218kh4X via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/249RCiq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LtlHOp via IFTTT

Parathyroid carcinoma presenting as mandibular ulceration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Oukessou, M. Ait El Kerdoudi, H. El Attar, M. Mahtar from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/218khlr via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/249SbsB via IFTTT

A rare cause of exophthalmos in children

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): N. Kolsi, Z. B-Rhaiem, J. Koubaa from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1oJcpJs via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LtlHOn via IFTTT

Parathyroid carcinoma presenting as mandibular ulceration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Oukessou, M. Ait El Kerdoudi, H. El Attar, M. Mahtar from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/218khlr via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LtlbzW via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/249Sbsv via IFTTT

Pulsatile tinnitus and a temporal bone mass

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D.T. Ginat, M.B. Gluth from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1oJcqgw via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LtldIa via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1LtlESV via IFTTT

GSE71559 Sexual polyploidization in Medicago sativa L.: impact on the phenotype, gene transcription and genome methylation

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
*Contributors* : Daniele Rosellini ; Nicoletta Ferradini ; Stefano Allegrucci ; Stefano Capomaccio ; Elisa D Zago ; Paola Leonetti ; Bachir Balech ; Riccardo Aversano ; Domenico Carputo ; Lara Reale ; Fabio Veronesi *Series Type* : Expression profiling by array *Organism* : Medicago sativa ; Medicago truncatula Polyploidization as the consequence of 2n gamete formation is a prominent mechanism in plant evolution. Studying its effects on the genome and its expression has both basic and applied interest. We crossed two diploid (2n=2x=16) M. sativa plants, a subsp. falcata seed parent ... περισσότερα »

The impact of causal attribution on stigmatizing attitudes toward a person who stutters

Publication date: Available online 17 February 2016 Source:Journal of Communication Disorders Author(s): Michael P. Boyle PurposeThis study investigated the impact of providing low control (biological) and high control (psychobehavioral) causal explanations for stuttering on a variety of stigma related variables including blame, anger, social distance, stereotypes, dislike, sympathy, willingness to help, and perceptions of potential […]

Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos

Publication date: Available online 16 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): O. Vella, F. Cuny, L. Robard, C. Bazille IntroductionBenign osteoblastoma is a rare fibrous bone tumour observed in children. Very few cases involving the paranasal sinuses have been reported.SummaryA 10-year-old child presented with a 1-month history of right exophthalmos. […]

Pulsatile tinnitus and a temporal bone mass

Publication date: Available online 16 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): D.T. Ginat, M.B. Gluth from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1oJcqgw via IFTTT

A rare cause of exophthalmos in children

Publication date: Available online 16 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): N. Kolsi, Z. B-Rhaiem, J. Koubaa from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1oJcpJs via IFTTT

Parathyroid carcinoma presenting as mandibular ulceration

Publication date: Available online 16 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Oukessou, M. Ait El Kerdoudi, H. El Attar, M. Mahtar from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/218khlr via IFTTT

Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Osteoblastoma of the maxillary sinus in a child presenting with exophthalmos via European Annals of Otorhinolaryngology, Head and Neck Diseases Publication date: Available online 16 February 2016 *Source:*European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): O. Vella, F. Cuny, L. Robard, C. Bazille IntroductionBenign osteoblastoma is a rare fibrous bone tumour observed in children. Very few cases involving the paranasal sinuses have been reported.SummaryA 10-year-old child presented with a 1-month history of right exophthalmos. Clinical and radiological assessment dem... περισσότερα »

Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer’s Disease-Diabetes Dual Therapy

Abstract At the present time, treatment of two most common degenerative disorders of elderly population i.e., Type 2 Diabetes Mellitus (T2DM) and Alzheimer’s disease (AD) is a major concern worldwide. As there are several evidences that proved strong linkages between these two disorders, the idea of using dual therapeutic agent for both the diseases might […]

Production and Characterization of Polyhydroxyalkanoates and Native Microorganisms Synthesized from Fatty Waste

Polyhydroxyalkanoates (PHAs) are biodegradable and biocompatible plastics. They are synthesized by a wide variety of microorganisms (i.e., fungi and bacteria) and some organisms such as plants, which share characteristics with petrochemical-based plastics. The most recent studies focus on finding inexpensive substrates and extraction strategies that allow reducing product costs, thus moving into a widespread market, […]

Salicylate-Induced Hearing Loss Trigger Structural Synaptic Modifications in the Ventral Cochlear Nucleus of Rats via Medial Olivocochlear (MOC) Feedback Circuit

Abstract Lesion-induced cochlear damage can result in synaptic outgrowth in the ventral cochlear nucleus (VCN). Tinnitus may be associated with the synaptic outgrowth and hyperactivity in the VCN. However, it remains unclear how hearing loss triggers structural synaptic modifications in the VCN of rats subjected to salicylate-induced tinnitus. To address this issue, we evaluated tinnitus-like […]

A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma

Background. Extrarenal retroperitoneal angiomyolipomas are rare. Aim. To review the literature. Results. Angiomyolipomas, previously classified as hamartomas, are now classified as benign tumours. Thirty cases of primary retroperitoneal angiomyolipomas have been reported. Diagnosis of the disease upon is based radiological and pathological findings of triphasic features of (a) fat and (b) blood vessels and myoid […]

Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration

Abstract Trophic factor treatment has been shown to improve the recovery of brain and spinal cord injury (SCI). In this study, we examined the effects of TSC1 (a combination of insulin-like growth factor 1 and transferrin) 4 and 8 h after SCI at the thoracic segment level (T12) in nestin-GFP transgenic mice. TSC1 treatment for […]

T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves

The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA+CD62L+), central memory (CM, CD45RA−CD62L+), effector memory (EM, CD45RA−CD62L−), and terminally differentiated […]

Pharmaceutics, Vol. 8, Pages 4: Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma

Cytochrome P450 drug metabolizing enzymes are implicated in personalized medicine for two main reasons. First, inter-individual variability in CYP3A4 expression is a confounding factor during cancer treatment. Second, inhibition or induction of CYP3A4 can trigger adverse drug–drug interactions. However, inflammation can downregulate CYP3A4 and other drug metabolizing enzymes and lead to altered metabolism of drugs […]

Fourier-Transform Infrared Absorption Spectroscopy in Binary Hydrocarbon-Alcohol Single Droplet Evaporation

Broadband absorption spectroscopy, by way of FTIR, was used to investigate the vapor cloud of a single millimeter sized liquid droplet suspended by a syringe as it evaporates at standard conditions. Single beam data were collected every 8 seconds resulting in a time-resolved record. Species concentrations were tracked using their resonant absorption peaks and correlated […]

Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis

This study compared the influence of type 2 diabetes on the occurrence of six periodontal pathogens in plaque samples of patients with and without chronic periodontitis. Levels of salivary MMP-8, MMP-9, RANKL, and OPG were also investigated. The study enrolled 31 patients with type 2 diabetes and chronic periodontitis (DM + CP), 29 with chronic […]

Evaluation of Malignancy Grade of Breast Cancer Using Perflubutane-Enhanced Ultrasonography

Publication date: Available online 16 February 2016 Source:Ultrasound in Medicine &amp; Biology Author(s): Norio Masumoto, Takayuki Kadoya, Ai Amioka, Keiko Kajitani, Hideo Shigematsu, Akiko Emi, Kazuo Matsuura, Koji Arihiro, Morihito Okada Whether the contrast effects of perflubutane on contrast-enhanced ultrasonography can predict the malignancy grade of breast cancer is unknown. We analyzed associations between perfusion […]

Neuropilin-2 promotes melanoma growth and progression in vivo.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
Tumor cell interactions with their microenvironment, and neighboring endothelial cells in particular, are critical for tumor cell survival and the metastatic process. Within the spectrum of tumors, melanomas are notorious for their ability to metastasize at a relatively early stage of development; however, little is known about the molecular pathways mediating this process. We recently performed a screen to assess critical mediators of melanoma metastasis by evaluating melanoma-endothelial cell communication. Neuropilin-2 (NRP2), a cell surface receptor involved in angiogenesis and ... περισσότερα »

Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
Unlike breast and thyroid cancer, the use of ultrasound (US)-guided fine needle aspiration cytology (FNAC) for preoperative staging is limited in melanoma. New US morphology criteria have shown that US-FNAC can correctly identify 50% of all involved sentinel nodes (SN) in melanoma patients before surgical excision. The aim of this study was to examine a new criterion: the echo-free island (EFI). A total of 1000 consecutively staged melanoma patients (Breslow thickness&gt;1 or from melanoma2 via als.fakia on Inoreader http://ift.tt/249GORp via IFTTT

Periprocedural Management of Direct Oral Anticoagulants: Comment on the 2015 American Society of Regional Anesthesia and Pain Medicine Guidelines.

Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 1 ώρα
No abstract available from Anaesthesia via ola Kala on Inoreader http://ift.tt/1OfV8fo via IFTTT

Neuropilin-2 promotes melanoma growth and progression in vivo.

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Tumor cell interactions with their microenvironment, and neighboring endothelial cells in particular, are critical for tumor cell survival and the metastatic process. Within the spectrum of tumors, melanomas are notorious for their ability to metastasize at a relatively early stage of development; however, little is known about the molecular pathways mediating this process. We recently performed a screen to assess critical mediators of melanoma metastasis by evaluating melanoma-endothelial cell communication. Neuropilin-2 (NRP2), a cell surface receptor involved in angiogenesis and ... περισσότερα »

Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity.

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Unlike breast and thyroid cancer, the use of ultrasound (US)-guided fine needle aspiration cytology (FNAC) for preoperative staging is limited in melanoma. New US morphology criteria have shown that US-FNAC can correctly identify 50% of all involved sentinel nodes (SN) in melanoma patients before surgical excision. The aim of this study was to examine a new criterion: the echo-free island (EFI). A total of 1000 consecutively staged melanoma patients (Breslow thickness&gt;1 or from melanoma2 via als.fakia on Inoreader http://ift.tt/249GORp via IFTTT

Salicylate-Induced Hearing Loss Trigger Structural Synaptic Modifications in the Ventral Cochlear Nucleus of Rats via Medial Olivocochlear (MOC) Feedback Circuit

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Lesion-induced cochlear damage can result in synaptic outgrowth in the ventral cochlear nucleus (VCN). Tinnitus may be associated with the synaptic outgrowth and hyperactivity in the VCN. However, it remains unclear how hearing loss triggers structural synaptic modifications in the VCN of rats subjected to salicylate-induced tinnitus. To address this issue, we evaluated tinnitus-like behavior in rats after salicylate treatment and compared the amplitude of the distortion product evoked otoacoustic emission (DPOAE) and auditory brainstem response (ABR) between control and ... περισσότερα »

Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Trophic factor treatment has been shown to improve the recovery of brain and spinal cord injury (SCI). In this study, we examined the effects of TSC1 (a combination of insulin-like growth factor 1 and transferrin) 4 and 8 h after SCI at the thoracic segment level (T12) in nestin-GFP transgenic mice. TSC1 treatment for 4 and 8 h increased the number of nestin-expressing cells around the lesion site and prevented Wallerian degeneration. Treatment with TSC1 for 4 h significantly increased heat shock protein (HSP)-32 and HSP-70 expression 1 and 2 mm from lesion site (both, ca... περισσότερα »

Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer’s Disease-Diabetes Dual Therapy

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract At the present time, treatment of two most common degenerative disorders of elderly population i.e., Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD) is a major concern worldwide. As there are several evidences that proved strong linkages between these two disorders, the idea of using dual therapeutic agent for both the diseases might be considered as a good initiative. Earlier reports have revealed that oral anti-diabetic drugs such as peroxisome proliferator activated receptor γ (PPARγ) agonists (thiazolidinediones) when used in T2DM patients suffering from A... περισσότερα »

Salicylate-Induced Hearing Loss Trigger Structural Synaptic Modifications in the Ventral Cochlear Nucleus of Rats via Medial Olivocochlear (MOC) Feedback Circuit

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Lesion-induced cochlear damage can result in synaptic outgrowth in the ventral cochlear nucleus (VCN). Tinnitus may be associated with the synaptic outgrowth and hyperactivity in the VCN. However, it remains unclear how hearing loss triggers structural synaptic modifications in the VCN of rats subjected to salicylate-induced tinnitus. To address this issue, we evaluated tinnitus-like behavior in rats after salicylate treatment and compared the amplitude of the distortion product evoked otoacoustic emission (DPOAE) and auditory brainstem response (ABR) between control and ... περισσότερα »

Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Trophic factor treatment has been shown to improve the recovery of brain and spinal cord injury (SCI). In this study, we examined the effects of TSC1 (a combination of insulin-like growth factor 1 and transferrin) 4 and 8 h after SCI at the thoracic segment level (T12) in nestin-GFP transgenic mice. TSC1 treatment for 4 and 8 h increased the number of nestin-expressing cells around the lesion site and prevented Wallerian degeneration. Treatment with TSC1 for 4 h significantly increased heat shock protein (HSP)-32 and HSP-70 expression 1 and 2 mm from lesion site (both, ca... περισσότερα »

Pharmaceutics, Vol. 8, Pages 4: Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Cytochrome P450 drug metabolizing enzymes are implicated in personalized medicine for two main reasons. First, inter-individual variability in CYP3A4 expression is a confounding factor during cancer treatment. Second, inhibition or induction of CYP3A4 can trigger adverse drug–drug interactions. However, inflammation can downregulate CYP3A4 and other drug metabolizing enzymes and lead to altered metabolism of drugs and essential vitamins and lipids. Little is known about effects of inflammation on expression of CYP450 genes controlling drug metabolism in the skin. Therefore, we ana... περισσότερα »

Hereditary angioedema in a Jordanian family with a novel missense mutation in the C1-inhibitor N-terminal domain

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Saied A Jaradat, Sonia Caccia, Rifaat Rawashdeh, Motasem Melhem, Ali Al-Hawamdeh, Thomas Carzaniga, Hazem Haddad Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is an autosomal dominant disease caused by mutations in the SERPING1 gene. A Jordanian family, including 14 individuals with C1-INH-HAE clinical symptoms, was studied. In the propositus and his parents, SERPING1 had four mutations leading to amino acid substitutions. Two are known polymorphic variants (c.167T&gt;C; p.Val34Ala and ... περισσότερα »

Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Paraskevas Iatropoulos, Marina Noris, Caterina Mele, Rossella Piras, Elisabetta Valoti, Elena Bresin, Manuela Curreri, Elena Mondo, Anna Zito, Sara Gamba, Serena Bettoni, Luisa Murer, Veronique Fremeaux-Bacchi, Marina Vivarelli, Francesco Emma, Erica Daina, Giuseppe Remuzzi BackgroundMembranoproliferative glomerulonephritis (MPGN) is an uncommon cause of chronic nephropathy recently reclassified into immunoglobulin-associated MPGN (Ig-MPGN) and C3 glomerulopathy (C3G). In this study we aimed: (1) to eva... περισσότερα »

Ηλεκτρισμός εγκεφάλου – Επιληψία

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 1 ώρα
Ο εγκέφαλος διαθέτει, όσο οι νευρώνες του είναι ζωντανοί, ένα ηλεκτρικό φορτίο που κυκλοφορεί με τη «μορφή» βιοηλεκτρικού ρεύματος. Σε φυσιολογικές καταστάσεις ζωής, το ηλεκτρικό ρεύμα αυτό φροντίζει όχι μόνο για την ήρεμη λειτουργία του εγκεφάλου αλλά και τη διατήρηση της ύπαρξής του. Τοπικές ή γενικευμένες διαταραχές του βιοηλεκτρικού αυτού ρεύματος, προκαλούν άμεσα λειτουργικές διαταραχές […] [image: iiQG?d=qj6IDK7rITs] [image: iiQG?i=RTn83K72VgA:Jo_0A6cMTn0:gIN9vFwOq] [image: 1Qld5uB] from Neurology via xlomafota13 on Inoreader http://ift.tt/1U7n5NL via IFTTT from #Med Blogs ... περισσότερα »

New Bismuth Germanate Oxide Nanoparticle Material for Biolabel Applications in Medicine

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Bismuth germanate (Bi4Ge3O12, BGO) has been the focus of several studies due to its scintillation properties. It has been employed as detector in scientific research and medicine, and herein we studied its possible biomedical applications. The photoluminescence properties of the uncoated and protein-coated nanoparticles were analyzed in different body fluids, at different pH. The nanoparticles… Continue reading New Bismuth Germanate Oxide Nanoparticle Material for Biolabel Applications in Medicine

DNA Modified with Metal Nanoparticles: Preparation and Characterization of Ordered Metal-DNA Nanostructures in a Solution and on a Substrate

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
DNA interaction with silver and aluminum nanoparticles in a solution has been investigated with the AFM, SEM, dynamic light scattering, viscometry, and spectral methods. The comparison of DNA interaction with nanoparticles synthesized by the reduction of Ag+ ions and with nanoparticles obtained by the electric discharge plasma method was done. DNA metallization in a solution… Continue reading DNA Modified with Metal Nanoparticles: Preparation and Characterization of Ordered Metal-DNA Nanostructures in a Solution and on a Substrate

Feasible Initial Population with Genetic Diversity for a Population-Based Algorithm Applied to the Vehicle Routing Problem with Time Windows

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
A stochastic algorithm for obtaining feasible initial populations to the Vehicle Routing Problem with Time Windows is presented. The theoretical formulation for the Vehicle Routing Problem with Time Windows is explained. The proposed method is primarily divided into a clustering algorithm and a two-phase algorithm. The first step is the application of a modified -means… Continue reading Feasible Initial Population with Genetic Diversity for a Population-Based Algorithm Applied to the Vehicle Routing Problem with Time Windows

Production and Characterization of Polyhydroxyalkanoates and Native Microorganisms Synthesized from Fatty Waste

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Polyhydroxyalkanoates (PHAs) are biodegradable and biocompatible plastics. They are synthesized by a wide variety of microorganisms (i.e., fungi and bacteria) and some organisms such as plants, which share characteristics with petrochemical-based plastics. The most recent studies focus on finding inexpensive substrates and extraction strategies that allow reducing product costs, thus moving into a widespread market,… Continue reading Production and Characterization of Polyhydroxyalkanoates and Native Microorganisms Synthesized from Fatty Waste

T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: naïve (N, CD45RA+CD62L+), central memory (CM, CD45RA−CD62L+), effector memory (EM, CD45RA−CD62L−), and terminally differentiated… Continue reading T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves

Fourier-Transform Infrared Absorption Spectroscopy in Binary Hydrocarbon-Alcohol Single Droplet Evaporation

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Broadband absorption spectroscopy, by way of FTIR, was used to investigate the vapor cloud of a single millimeter sized liquid droplet suspended by a syringe as it evaporates at standard conditions. Single beam data were collected every 8 seconds resulting in a time-resolved record. Species concentrations were tracked using their resonant absorption peaks and correlated… Continue reading Fourier-Transform Infrared Absorption Spectroscopy in Binary Hydrocarbon-Alcohol Single Droplet Evaporation

A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background. Extrarenal retroperitoneal angiomyolipomas are rare. Aim. To review the literature. Results. Angiomyolipomas, previously classified as hamartomas, are now classified as benign tumours. Thirty cases of primary retroperitoneal angiomyolipomas have been reported. Diagnosis of the disease upon is based radiological and pathological findings of triphasic features of (a) fat and (b) blood vessels and myoid… Continue reading A Review of the Literature on Extrarenal Retroperitoneal Angiomyolipoma

Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
This study compared the influence of type 2 diabetes on the occurrence of six periodontal pathogens in plaque samples of patients with and without chronic periodontitis. Levels of salivary MMP-8, MMP-9, RANKL, and OPG were also investigated. The study enrolled 31 patients with type 2 diabetes and chronic periodontitis (DM + CP), 29 with chronic… Continue reading Influence of Type 2 Diabetes on Prevalence of Key Periodontal Pathogens, Salivary Matrix Metalloproteinases, and Bone Remodeling Markers in Sudanese Adults with and without Chronic Periodontitis

Benington schoolboy flies to the USA for specialist cancer treatment – Hertfordshire Mercury

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Benington schoolboy flies to the USA for specialist cancer treatment Hertfordshire Mercury Brave schoolboy Benjamin Carter has flown out to the United States for a specialist cancer treatment not available in the UK. The 11-year-old, of Walkern Road, Benington, suffers from rhabdomyosarcoma (RMS), which affects the muscle tissue in his larynx. from #Head and Neck… Continue reading Benington schoolboy flies to the USA for specialist cancer treatment – Hertfordshire Mercury

ESUS: Fire and forget? So einfach ist das nicht

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Kryptogener Insult Bis zu zwei Drittel der Patienten mit kryptogenem Schlaganfall entwickeln ein Vorhofflimmern – wenn man nur lange genug danach sucht. Sollte man die Suche also nicht besser lassen und gleich antikoagulieren? from #Medicine-Sfakianakis via simeraentaxei on Inoreader http://ift.tt/218kh4X via IFTTT

A rare cause of exophthalmos in children

Publication date: Available online 16 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): N. Kolsi, Z. B-Rhaiem, J. Koubaa from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oJcpJs via IFTTT

Parathyroid carcinoma presenting as mandibular ulceration

Publication date: Available online 16 February 2016 Source:European Annals of Otorhinolaryngology, Head and Neck Diseases Author(s): Y. Oukessou, M. Ait El Kerdoudi, H. El Attar, M. Mahtar from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/218khlr via IFTTT

Reporting on Adverse Clinical Events

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1oJcmgL via IFTTT

ESUS: Fire and forget? So einfach ist das nicht

Kryptogener Insult Bis zu zwei Drittel der Patienten mit kryptogenem Schlaganfall entwickeln ein Vorhofflimmern – wenn man nur lange genug danach sucht. Sollte man die Suche also nicht besser lassen und gleich antikoagulieren? from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/218kh4X via IFTTT

Salicylate-Induced Hearing Loss Trigger Structural Synaptic Modifications in the Ventral Cochlear Nucleus of Rats via Medial Olivocochlear (MOC) Feedback Circuit

Abstract Lesion-induced cochlear damage can result in synaptic outgrowth in the ventral cochlear nucleus (VCN). Tinnitus may be associated with the synaptic outgrowth and hyperactivity in the VCN. However, it remains unclear how hearing loss triggers structural synaptic modifications in the VCN of rats subjected to salicylate-induced tinnitus. To address this issue, we evaluated tinnitus-like […]

Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration

Abstract Trophic factor treatment has been shown to improve the recovery of brain and spinal cord injury (SCI). In this study, we examined the effects of TSC1 (a combination of insulin-like growth factor 1 and transferrin) 4 and 8 h after SCI at the thoracic segment level (T12) in nestin-GFP transgenic mice. TSC1 treatment for […]

Kinetics and Molecular Docking Study of an Anti-diabetic Drug Glimepiride as Acetylcholinesterase Inhibitor: Implication for Alzheimer’s Disease-Diabetes Dual Therapy

Abstract At the present time, treatment of two most common degenerative disorders of elderly population i.e., Type 2 Diabetes Mellitus (T2DM) and Alzheimer’s disease (AD) is a major concern worldwide. As there are several evidences that proved strong linkages between these two disorders, the idea of using dual therapeutic agent for both the diseases might […]

Salicylate-Induced Hearing Loss Trigger Structural Synaptic Modifications in the Ventral Cochlear Nucleus of Rats via Medial Olivocochlear (MOC) Feedback Circuit

Abstract Lesion-induced cochlear damage can result in synaptic outgrowth in the ventral cochlear nucleus (VCN). Tinnitus may be associated with the synaptic outgrowth and hyperactivity in the VCN. However, it remains unclear how hearing loss triggers structural synaptic modifications in the VCN of rats subjected to salicylate-induced tinnitus. To address this issue, we evaluated tinnitus-like […]

Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration

Abstract Trophic factor treatment has been shown to improve the recovery of brain and spinal cord injury (SCI). In this study, we examined the effects of TSC1 (a combination of insulin-like growth factor 1 and transferrin) 4 and 8 h after SCI at the thoracic segment level (T12) in nestin-GFP transgenic mice. TSC1 treatment for […]

Pharmaceutics, Vol. 8, Pages 4: Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma

Cytochrome P450 drug metabolizing enzymes are implicated in personalized medicine for two main reasons. First, inter-individual variability in CYP3A4 expression is a confounding factor during cancer treatment. Second, inhibition or induction of CYP3A4 can trigger adverse drug–drug interactions. However, inflammation can downregulate CYP3A4 and other drug metabolizing enzymes and lead to altered metabolism of drugs […]

Pharmaceutics, Vol. 8, Pages 4: Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma

Cytochrome P450 drug metabolizing enzymes are implicated in personalized medicine for two main reasons. First, inter-individual variability in CYP3A4 expression is a confounding factor during cancer treatment. Second, inhibition or induction of CYP3A4 can trigger adverse drug–drug interactions. However, inflammation can downregulate CYP3A4 and other drug metabolizing enzymes and lead to altered metabolism of drugs […]

Hereditary angioedema in a Jordanian family with a novel missense mutation in the C1-inhibitor N-terminal domain

Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Saied A Jaradat, Sonia Caccia, Rifaat Rawashdeh, Motasem Melhem, Ali Al-Hawamdeh, Thomas Carzaniga, Hazem Haddad Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is an autosomal dominant disease caused by mutations in the SERPING1 gene. A Jordanian family, including 14 individuals with C1-INH-HAE clinical symptoms, was studied. […]

Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

Publication date: March 2016 Source:Molecular Immunology, Volume 71 Author(s): Paraskevas Iatropoulos, Marina Noris, Caterina Mele, Rossella Piras, Elisabetta Valoti, Elena Bresin, Manuela Curreri, Elena Mondo, Anna Zito, Sara Gamba, Serena Bettoni, Luisa Murer, Veronique Fremeaux-Bacchi, Marina Vivarelli, Francesco Emma, Erica Daina, Giuseppe Remuzzi BackgroundMembranoproliferative glomerulonephritis (MPGN) is an uncommon cause of chronic nephropathy recently reclassified […]

Diseases, Vol. 4, Pages 11: Antioxidants and Cardiovascular Risk Factors

Cardiovascular disease (CVD), the world’s primary cause of death and disability, represents a global health problem and involves a great public financial commitment in terms of both inability to work and pharmaceutical costs. CVD is characterized by a cluster of disorders, associated with complex interactions between multiple risk factors. The early identification of high cardiovascular […]

High-resolution dynamic CE-MRA of the thorax enabled by iterative TWIST reconstruction

Purpose To evaluate the clinical benefit of using a new iterative reconstruction technique fully integrated on a standard clinical scanner and reconstruction system using a TWIST acquisition for high-resolution dynamic three-dimensional contrast-enhanced MR angiography (CE-MRA). Methods Low-dose, high-resolution TWIST datasets of 11 patients were reconstructed using both standard GRAPPA-based reconstruction for reference and iterative reconstruction, […]

Reference-free single-pass EPI Nyquist ghost correction using annihilating filter-based low rank Hankel matrix (ALOHA)

Purpose MR measurements from an echo-planar imaging (EPI) sequence produce Nyquist ghost artifacts that originate from inconsistencies between odd and even echoes. Several reconstruction algorithms have been proposed to reduce such artifacts, but most of these methods require either additional reference scans or multipass EPI acquisition. This article proposes a novel and accurate single-pass EPI […]

Hereditary angioedema in a Jordanian family with a novel missense mutation in the C1-inhibitor N-terminal domain

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Saied A Jaradat, Sonia Caccia, Rifaat Rawashdeh, Motasem Melhem, Ali Al-Hawamdeh, Thomas Carzaniga, Hazem Haddad Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is an autosomal dominant disease caused by mutations in the SERPING1 gene. A Jordanian family, including 14 individuals with C1-INH-HAE clinical symptoms, was studied. In the propositus and his parents, SERPING1 had four mutations leading to amino acid substitutions. Two are known polymorphic variants (c.167T&gt;C; p.Val34Ala and ... περισσότερα »

Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Paraskevas Iatropoulos, Marina Noris, Caterina Mele, Rossella Piras, Elisabetta Valoti, Elena Bresin, Manuela Curreri, Elena Mondo, Anna Zito, Sara Gamba, Serena Bettoni, Luisa Murer, Veronique Fremeaux-Bacchi, Marina Vivarelli, Francesco Emma, Erica Daina, Giuseppe Remuzzi BackgroundMembranoproliferative glomerulonephritis (MPGN) is an uncommon cause of chronic nephropathy recently reclassified into immunoglobulin-associated MPGN (Ig-MPGN) and C3 glomerulopathy (C3G). In this study we aimed: (1) to eva... περισσότερα »

Effects of 36.6 GHz and static magnetic field on degree of endoreduplication in Drosophila melanogaster polytene chromosomes

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες
10.3109/09553002.2016.1137105<br>Liliia D. Dyka from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1mH09Yi via IFTTT

Exposure to electromagnetic field attenuates oxygen-glucose deprivation-induced microglial cell death by reducing intracellular Ca2+ and ROS

Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 2 ώρες
10.3109/09553002.2016.1136851<br>Cao Nguyen Duong from Anatomy Pathology via xlomafota13 on Inoreader http://ift.tt/1mH09Y8 via IFTTT

Hereditary angioedema in a Jordanian family with a novel missense mutation in the C1-inhibitor N-terminal domain

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 2 ώρες
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Saied A Jaradat, Sonia Caccia, Rifaat Rawashdeh, Motasem Melhem, Ali Al-Hawamdeh, Thomas Carzaniga, Hazem Haddad Hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE) is an autosomal dominant disease caused by mutations in the SERPING1 gene. A Jordanian family, including 14 individuals with C1-INH-HAE clinical symptoms, was studied. In the propositus and his parents, SERPING1 had four mutations leading to amino acid substitutions. Two are known polymorphic variants (c.167T&gt;C; p.Val34Ala and ... περισσότερα »

Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 2 ώρες
Publication date: March 2016 *Source:*Molecular Immunology, Volume 71 Author(s): Paraskevas Iatropoulos, Marina Noris, Caterina Mele, Rossella Piras, Elisabetta Valoti, Elena Bresin, Manuela Curreri, Elena Mondo, Anna Zito, Sara Gamba, Serena Bettoni, Luisa Murer, Veronique Fremeaux-Bacchi, Marina Vivarelli, Francesco Emma, Erica Daina, Giuseppe Remuzzi BackgroundMembranoproliferative glomerulonephritis (MPGN) is an uncommon cause of chronic nephropathy recently reclassified into immunoglobulin-associated MPGN (Ig-MPGN) and C3 glomerulopathy (C3G). In this study we aimed: (1) to eva... περισσότερα »

Ultrasound of the sentinel node in melanoma patients: echo-free island is a discriminatory morphologic feature for node positivity.

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 2 ώρες
Unlike breast and thyroid cancer, the use of ultrasound (US)-guided fine needle aspiration cytology (FNAC) for preoperative staging is limited in melanoma. New US morphology criteria have shown that US-FNAC can correctly identify 50% of all involved sentinel nodes (SN) in melanoma patients before surgical excision. The aim of this study was to examine a new criterion: the echo-free island (EFI). A total of 1000 consecutively staged melanoma patients (Breslow thickness&gt;1 or from thyroid via a.lsfakia on Inoreader http://ift.tt/249GORp via IFTTT

Maxillofacial trauma scoring systems: a review

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Injury from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SxBOCm via IFTTT

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