Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Δευτέρα 14 Μαρτίου 2016

OtoRhinoLaryngology & Medicine,New Articles,March 14th,2016


Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 15 δευτερόλεπτα
*Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk.*Radiother Oncol. 2016 Mar 9;Authors: Dean JA, Welsh LC, McQuaid D, Wong KH, Aleksic A, Dunne E, Islam MR, Patel A, Patel P, Petkar I, Phillips I, Sham J, Newbold KL, Bhide SA, Harrington KJ, Gulliford SL, Nutting CMAbstractBACKGROUND AND PURPOSE: Current oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of the oral mucosa is likely to improve these ...περισσότερα »

Recurrent G12V pathogenic mutation in adenomatoid odontogenic tumours

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 15 δευτερόλεπτα
The adenomatoid odontogenic tumour (AOT) is a non-aggressive encapsulated tumour, being usually diagnosed in association with an unerupted permanent maxillary canine [1,2]. There are scarce reports of multiple AOTs [3–5] and a patient with Schimmelpenning syndrome (SS) with AOT was reported [6]. SS is characterized by sebaceous nevi, associated with ipsilateral abnormalities of the central nervous system, resulting from postzygotic autosomal dominant HRAS or KRAS lethal mutations that survive by somatic mosaicism [7].from #ORL via xlomafota13 on Inoreader http://ift.tt/1YLbC7gvi...περισσότερα »

The linea aspera as a rotational landmark: an anatomical MRI-based study.

Alexandros G. SfakianakisστοHead and NeckΠριν από 33 δευτερόλεπτα
*The linea aspera as a rotational landmark: an anatomical MRI-based study.*Surg Radiol Anat. 2016 Mar 12;Authors: Reple G, Felden A, Feydy A, Anract P, Biau DAbstractPURPOSE: The linea aspera can be used as a landmark to assess the rotation of the distal femoral epiphysis when performing an endoprostheses. However, no study has assessed the reliability of this landmark. We therefore asked whether the linea aspera could be used as a rotational landmark for positioning distal femoral knee megaprostheses. MATERIALS: This is an anatomic MRI-based study of 50 femurs (27 subjects). ...περισσότερα »

Personalized treatment of advanced non-small-cell lung cancer in routine clinical practice.

Alexandros G. SfakianakisστοHead and NeckΠριν από 36 δευτερόλεπτα
*Personalized treatment of advanced non-small-cell lung cancer in routine clinical practice.*Cancer Metastasis Rev. 2016 Mar 12; Authors: Pirker R, Filipits MAbstractPersonalized treatment of patients with advanced non-small-cell lung cancer based on clinical and molecular tumor features has entered clinical routine practice. The 2015 pathological classification of lung cancer mandates immunohistochemical and molecular analysis. Therapeutic strategies focused on inhibition of angiogenesis and growth factor receptor signaling. Inhibitors of angiogenesis and monoclonal antibodie...περισσότερα »

Morphological Continuum of mucocele like tumor with its Diagnostic Dilemmas – A Case Report with Cytohistological Correlation

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 2 δευτερόλεπτα
2016-03-14T03-30-38Z*Source:* The Southeast Asian Journal of Case Report and ReviewDr.Neelam Sood, Dr.Priyanka Bhatia Soni. Introduction: A Mucocele-like tumor is a rare breast lesion, characterized by mucin-filled cysts and extravasated mucin present in the adjacent stroma. First described by Rosen as a benign entity, it is now considered as a continuum of different pathological lesions, ranging from benign ductal hyperplasias , atypical ductal hyperplasia , ductal carcinoma in situ and mucinous carcinomas. Case presentation: We describe a case of Mucocele like tumor of the breas...περισσότερα »

Atmosphere, Vol. 7, Pages 45: Soot Nanoparticles Could Partake in Nucleation of Biogenic Particles in the Atmosphere: Using Fullerene as a Model Compound

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 3 δευτερόλεπτα
The detection of existence of fullerenes (C60 and C70) makes it necessary to explore whether soot nanoparticles can participate in new nanometer-sized particle formation and growth in the atmosphere. This study describes a theoretical investigation at multiple levels on the role of the fullerenes (as model compounds to represent nanoparticles of soot) in the formation of complexes with a common atmospheric nucleating precursor (sulfuric acid, SA) and a biogenic organic acid (cis-pinonic acid, CPA), as well as initial growth of nano-sized biogenic aerosols. Quantum chemical density...περισσότερα »

Micromachines, Vol. 7, Pages 48: Experimental Analysis of Porosity and Permeability in Pressed Paper

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 3 δευτερόλεπτα
In this paper, we report an analysis of pressed paper in terms of porosity and permeability. Previously, we reported a pressed paper that exhibits decreased porosity and permeability. Additionally, its applications into programmed sample delivery as well as flow rate control were reported. However, there is a need for a theoretical analysis of pressed paper in terms of porosity and permeability for a more precise design principle and its applications because porosity and permeability are important factors in determining fluidic behavior. Here, we propose a theoretical model for an...περισσότερα »

Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 3 δευτερόλεπτα
*Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk.*Radiother Oncol. 2016 Mar 9;Authors: Dean JA, Welsh LC, McQuaid D, Wong KH, Aleksic A, Dunne E, Islam MR, Patel A, Patel P, Petkar I, Phillips I, Sham J, Newbold KL, Bhide SA, Harrington KJ, Gulliford SL, Nutting CMAbstractBACKGROUND AND PURPOSE: Current oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of the oral mucosa is likely to improve these ...περισσότερα »

Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Assessment of fully-automated atlas-based segmentation of novel oral mucosal surface organ-at-risk.*Radiother Oncol. 2016 Mar 9;Authors: Dean JA, Welsh LC, McQuaid D, Wong KH, Aleksic A, Dunne E, Islam MR, Patel A, Patel P, Petkar I, Phillips I, Sham J, Newbold KL, Bhide SA, Harrington KJ, Gulliford SL, Nutting CMAbstractBACKGROUND AND PURPOSE: Current oral mucositis normal tissue complication probability models, based on the dose distribution to the oral cavity volume, have suboptimal predictive power. Improving the delineation of the oral mucosa is likely to improve these ...περισσότερα »

Personalized treatment of advanced non-small-cell lung cancer in routine clinical practice.

Alexandros G. SfakianakisστοHead and NeckΠριν από 6 δευτερόλεπτα
*Personalized treatment of advanced non-small-cell lung cancer in routine clinical practice.*Cancer Metastasis Rev. 2016 Mar 12; Authors: Pirker R, Filipits MAbstractPersonalized treatment of patients with advanced non-small-cell lung cancer based on clinical and molecular tumor features has entered clinical routine practice. The 2015 pathological classification of lung cancer mandates immunohistochemical and molecular analysis. Therapeutic strategies focused on inhibition of angiogenesis and growth factor receptor signaling. Inhibitors of angiogenesis and monoclonal antibodie...περισσότερα »

Shell-isolated nanoparticle-enhanced Raman spectroscopy study of the adsorption behaviour of DNA bases on Au(111) electrode surfaces

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 9 δευτερόλεπτα
[image: CrossMark.jpg]*Analyst*, 2016, Accepted Manuscript*DOI*: 10.1039/C6AN00180G, PaperBao-Ying Wen, Xi Jin, Yue Li, Ya-Hao Wang, Chaoyu Li, Miao-Miao Liang, Rajapandiyan Panneerselvam, qingchi xu, De-Yin Wu, Zhilin Yang, Jian-Feng Li, Zhong-qun TianFor the first time, we used electrochemical shell-isolated nanoparticle-enhanced Raman spectroscopy (EC-SHINERS) technique to in-situ characterize the adsorption behaviour of four DNA bases (adenine, guanine, thymine, and cytosine) on atomically...The content of this RSS Feed (c) The Royal Society of Chemistryfrom BioChemistry ...περισσότερα »

Rational control of nano-scale metal-catalysts for biomass conversion

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 9 δευτερόλεπτα
[image: CrossMark.jpg]*Chem. Commun.*, 2016, Accepted Manuscript*DOI*: 10.1039/C6CC00336B, Feature ArticleYunzhu Wang, Sudipta De, Ning YanNano-scale metal particles have huge potential due to their wide and diverse catalytic applications. Recently, they have shown numerous applications in the field of biomass conversion. The proposed contribution is... The content of this RSS Feed (c) The Royal Society of Chemistryfrom BioChemistry via xlomafota13 on Inoreader http://ift.tt/1UseAwPvia IFTTT

Deposition, Patterning, and Utility of Conductive Materials for the Rapid Prototyping of Chemical and Bioanalytical Devices

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 9 δευτερόλεπτα
[image: CrossMark.jpg]*Analyst*, 2016, Accepted Manuscript*DOI*: 10.1039/C6AN00210B, MinireviewLeyla Soleymani, Christine GabardoRapid prototyping is a critical step in the product development cycle of miniaturized chemical and bioanalytical devices, often categorized as lab-on-a-chip devices, biosensors, and micro-total analysis systems. While high throughput...The content of this RSS Feed (c) The Royal Society of Chemistryfrom BioChemistry via xlomafota13 on Inoreader http://ift.tt/1RhsBrFvia IFTTT

Absence of Flexor Carpi Radialis during an Elective Carpometacarpal Arthroplasty of the Thumb: A Rare Anatomical Variation

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 11 δευτερόλεπτα
Purpose. We present an extremely rare anatomical variation of unilateral flexor carpi radialis (FCR) absence. This rare anatomical variation posed a clinical dilemma to us and we highlight the importance of the surgeon being aware of this anatomical variation of an important structure both as a reconstruction tool and as an anatomical landmark. Methods. This anatomical variation of the unilaterally absent FCR was found upon dissection during a carpometacarpal arthroplasty of the thumb. Results. Upon the discovery of an absent FCR tendon, we proceeded with a simple trapeziectomy. C...περισσότερα »

The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.

Alexandros G. SfakianakisστοThe OesophagusΠριν από 12 δευτερόλεπτα
*The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective.*Dig Dis Sci. 2016 Mar 12;Authors: To H, Clemons NJ, Duong CP, Trainer AH, Phillips WAAbstractBarrett's esophagus (BE) is intestinal metaplasia of the lower esophagus and a precursor lesion for esophageal adenocarcinoma (EAC). Both are important health issues as they have rising incidences in the Western world. Improving the management of BE relies on understanding the underlying biology of this disease, but the exact biological mechanisms have been difficult to determine. BE is generally though...περισσότερα »

HPV status is associated with altered PIWI-interacting RNA expression pattern in head and neck cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
HPV status is associated with altered PIWI-interacting RNA expression pattern in head and neck cancer: Head and neck squamous cell carcinoma (HNSCC) affects over 550,000 patients worldwide each year [1]. Tobacco and alcohol consumption, together with human papillomavirus (HPV) infection are the main etiological factors [2–4]. Many studies have found that patients with HPV-positive HNSCC have a better prognosis, with increased survival and less chance of recurrence [5–7]. However, there have been contradictory reports showing either no or poor associations with outcome. Nevertheless, ...περισσότερα »

Atmosphere, Vol. 7, Pages 44: Weather and Tourism: Thermal Comfort and Zoological Park Visitor Attendance

Weather events have the potential to greatly impact business operations and profitability, especially in outdoor-oriented economic sectors such as Tourism, Recreation, and Leisure (TRL). Although a substantive body of work focuses on the macroscale impacts of climate change, less is known about how daily weather events influence attendance decisions, particularly relating to the physiological thermal […]

Atmosphere, Vol. 7, Pages 45: Soot Nanoparticles Could Partake in Nucleation of Biogenic Particles in the Atmosphere: Using Fullerene as a Model Compound

The detection of existence of fullerenes (C60 and C70) makes it necessary to explore whether soot nanoparticles can participate in new nanometer-sized particle formation and growth in the atmosphere. This study describes a theoretical investigation at multiple levels on the role of the fullerenes (as model compounds to represent nanoparticles of soot) in the formation […]

Atmosphere, Vol. 7, Pages 43: Reconstructing Fire Records from Ground-Based Routine Aerosol Monitoring

Long-term fire records are important to understanding the trend of biomass burning and its interactions with air quality and climate at regional and global scales. Traditionally, such data have been compiled from ground surveys or satellite remote sensing. To obtain aerosol information during a fire event to use in analyzing air quality, we propose a […]

Atmosphere, Vol. 7, Pages 44: Weather and Tourism: Thermal Comfort and Zoological Park Visitor Attendance

Weather events have the potential to greatly impact business operations and profitability, especially in outdoor-oriented economic sectors such as Tourism, Recreation, and Leisure (TRL). Although a substantive body of work focuses on the macroscale impacts of climate change, less is known about how daily weather events influence attendance decisions, particularly relating to the physiological thermal […]

Atmosphere, Vol. 7, Pages 45: Soot Nanoparticles Could Partake in Nucleation of Biogenic Particles in the Atmosphere: Using Fullerene as a Model Compound

The detection of existence of fullerenes (C60 and C70) makes it necessary to explore whether soot nanoparticles can participate in new nanometer-sized particle formation and growth in the atmosphere. This study describes a theoretical investigation at multiple levels on the role of the fullerenes (as model compounds to represent nanoparticles of soot) in the formation […]

Atmosphere, Vol. 7, Pages 43: Reconstructing Fire Records from Ground-Based Routine Aerosol Monitoring

Long-term fire records are important to understanding the trend of biomass burning and its interactions with air quality and climate at regional and global scales. Traditionally, such data have been compiled from ground surveys or satellite remote sensing. To obtain aerosol information during a fire event to use in analyzing air quality, we propose a […]

Researchers suggest blueberries could be used to fight Alzheimer’s

Two small-scale studies into the effects of freeze-dried blueberry powder suggest that the berries could help improve brain function and cognitive performance in some older adults. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SMcEzh via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Researchers suggest blueberries could be used to fight Alzheimer’s

Two small-scale studies into the effects of freeze-dried blueberry powder suggest that the berries could help improve brain function and cognitive performance in some older adults. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SMcEzh via IFTTT

Pathologic Fracture in Osteosarcoma: Association with poorer overall survival

Publication date: Available online 14 March 2016 Source:European Journal of Surgical Oncology (EJSO) Author(s): Abhijeet Ashok Salunke, Jaymin Shah, Nayan Gupta, Jyotindra Pandit from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RZgine via IFTTT

Cancers, Vol. 8, Pages 35: Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy

Tumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of proteins between the nucleus and cytoplasm is complex. It occurs through nuclear pores and exported proteins […]

Margin to tumor thickness ratio – A predictor of local recurrence and survival in oral squamous cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Margin to tumor thickness ratio – A predictor of local recurrence and survival in oral squamous cell carcinoma: Surgical resection is the mainstay of treatment for oral squamous cell carcinoma (OSCC). Satisfactory oncologic resections require negative and adequate resection margins. A microscopic margin of 5mm has traditionally been accepted as adequate for various oral cavity sub-sites [1,2]. This definition, however, of adequate surgical resection remains controversial as some authors propose 2mm to be sufficient [3] while others advocate for more than 7mm [4]. Ch’ng et al. [5] an...περισσότερα »

Toxicities and early outcomes in a phase 1 trial of photodynamic therapy for premalignant and early stage head and neck tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Toxicities and early outcomes in a phase 1 trial of photodynamic therapy for premalignant and early stage head and neck tumors: Photodynamic therapy (PDT) uses a photosensitizing agent and light to kill cells, involving delivery of a photosensitizer or photosensitizer precursor followed by illumination at a specific wavelength of light. The appeal of PDT in oncology has been that photosensitizers such as Photofrin are retained in tumor tissues for longer periods compared to normal tissue. The selectivity of photosensitizer for diseased tissue, as well as the ability to target the li...περισσότερα »

Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 14 δευτερόλεπτα
Assessment of voice, speech, and related quality of life in advanced head and neck cancer patients 10-years+ after chemoradiotherapy: In patients with advanced head and neck cancer (HNC), both the tumor and its treatment with combined chemoradiotherapy (CRT) can adversely impact voice and speech outcomes. In patients with cancers of the oral cavity and oropharynx, destructive effects of the tumor will mainly affect patients’ articulation and/or speech, whereas in laryngeal cancer patients, the tumor often has negative effects on voice quality [1,2]. Treatment effects of (chemo-) rad...περισσότερα »

Staging significance of bone invasion in small-sized (4cm or less) oral squamous cell carcinoma as defined by the American Joint Committee on Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Staging significance of bone invasion in small-sized (4cm or less) oral squamous cell carcinoma as defined by the American Joint Committee on Cancer: According to the 2010 American Joint Committee on Cancer (AJCC) [1], primary oral squamous cell carcinoma (OSCC) patients with medullary bone invasion should be defined as T4a. Some studies show that OSCC bone invasion has a significant effect on survival in univariate analysis [2,3]. Furthermore, infiltrative bone invasion was shown to be associated with patient prognosis after correcting for the effects of other variables [4].

Evidence for a stabilization of incidence rates for base of tongue and tonsil carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Evidence for a stabilization of incidence rates for base of tongue and tonsil carcinoma in the U.S. white population: Increasing age-standardized incidence rates (ASIRs) for oropharyngeal (OP) squamous cell carcinomas (SCC), have been reported using cancer registries in many western countries, although the time periods and factors involved differ [1–4]. In East Germany, however, ASIRs for OPSCC did not increase after 2008 (through 2011) for males [4]. It was also noted [4] that previously rising ASIRs had stabilized from 2000–2006 to 2007–2012 in Stockholm County, Sweden, for SCC of...περισσότερα »

Human papilloma virus and other biologic markers in nasopharyngeal cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Clinical implications of human papilloma virus and other biologic markers in nasopharyngeal cancer: Human papilloma virus (HPV) is associated with both the occurrence and prognosis of oropharyngeal cancer. However, few studies have examined the relationship between HPV and nasopharyngeal cancer (NPC). This study investigated the clinical implications of HPV and other molecular markers, including p16, p53, and epidermal growth factor receptor (EGFR), for NPC patients.

Salivary secretory leukocyte protease inhibitor (SLPI) and HNC

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Salivary secretory leukocyte protease inhibitor (SLPI) and head and neck cancer: The Cancer Prevention Study II Nutrition Cohort: Head and neck cancer (HNC) is the eighth most common cancer worldwide [1], arising in the epithelial lining of the oral cavity, pharynx, and larynx. Lifestyle risk factors include tobacco and alcohol consumption, although human papillomavirus (HPV) infection has recently emerged as a contributing factor, especially at the oropharynx [2,3]. Although early-stage cancers have a favorable prognosis, there are no reliable methods for the early detection of HNC...περισσότερα »

Cetuximab in recurrent/metastatic disease of squamous cell carcinoma of head and neck

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Emergence of long-term surviving patients with the introduction of Cetuximab in recurrent/metastatic disease of squamous cell carcinoma of head and neck: Approximately 30% of all patients diagnosed with Squamous Cell Carcinoma of the Head and Neck (SCCHN) will ultimately have recurrent disease or distant metastasis that render them unable to receive radical treatment. Systemic palliative therapy is then the treatment of choice, achieving a median overall survival of 10months with the combination of chemotherapy (CT) and Cetuximab [1].

Polymorphous low-grade adenocarcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Polymorphous low-grade adenocarcinoma: A Danish national study: Polymorphous low-grade adenocarcinoma (PLGA) is a slow-growing salivary gland malignancy with a non-aggressive behaviour [1]. PLGA is predominantly found in females in their sixth to seventh decade, and it most commonly arises in the minor salivary glands, with more than half of cases involving the palate [2]. It can also occur in minor salivary glands in the rest of the upper aero-digestive tract, as well as in major salivary glands [1,3]. PLGA accounts for approximately 25% of all intraoral malignant salivary gland tu...περισσότερα »

RNA in-situ hybridization is a practical and effective method for determining HPV status of oropharyngeal squamous cell carcinoma including discordant cases that are p16 positive by immunohistochemistry but HPV negative by DNA in-situ hybridization

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
RNA in-situ hybridization is a practical and effective method for determining HPV status of oropharyngeal squamous cell carcinoma including discordant cases that are p16 positive by immunohistochemistry but HPV negative by DNA in-situ hybridization: High-risk human papillomavirus (HPV) has been confirmed as a causative agent in a subset of head and neck squamous cell carcinomas characterized by origin from the oropharynx, a unique demographic profile, and improved clinical outcomes compared to non-HPV-related squamous cell carcinoma [1–4]. Accordingly, HPV status has become a powerf...περισσότερα »

From flat into concave shape in soft tissue free flaps in oral cavity reconstruction: The origami technique

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
From flat into concave shape in soft tissue free flaps in oral cavity reconstruction: The origami technique: The reconstruction of the head and neck post oncological resection poses a challenge using conventional methods. Flap reconstruction has become commonplace in these types of reconstructions where it must accomplish and fulfil mainly seven purposes: adequate wound coverage, prevention of infections, sealing of dead spaces, functional restoration, provide enough volume to restore the entire defect, protect the underlying structures during postoperative radiotherapy and lastly p...περισσότερα »

Intra-operative radiation therapy (IORT) in recurrent head and neck cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Intra-operative radiation therapy (IORT) in recurrent head and neck cancer: Intraoperative radiotherapy (IORT) an innovative technique that assures the delivery of radiation immediately after surgical resection and thus directly on tumor bed, without the necessity of excessive radiation protection measures. The clinical data regarding the use of IORT in head and neck cancer are little and a comprehensive and evidence-based analysis of recurrent head and neck cancer is still pending. Despite an aggressive multidisciplinary management, in head and neck cancer it is difficult to achiev...περισσότερα »

Dendritic cells generated from peripheral blood monocytes (Mo-DCs) and stimulated with laryngeal cancer cell lysates are not good enough in stimulating anti-tumor immunity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Dendritic cells generated from peripheral blood monocytes (Mo-DCs) and stimulated with laryngeal cancer cell lysates are not good enough in stimulating anti-tumor immunity: The use of immunotherapy as an adjuvant traditional treatment could prevent metastasis and give a chance for longer survival of cancer patients. It is known that the dendritic cells are the most effective antigen presenting cells (APC) and are the only APCs which activate innate T cells, therefore, they may involve additional forces to attack the cancerous cells [3]. The purpose of the use of immunotherapy is to ...περισσότερα »

Positive frozen section margins predict local recurrence in R0-resected squamous cell carcinoma of the head and neck

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Positive frozen section margins predict local recurrence in R0-resected squamous cell carcinoma of the head and neck: Initial surgery with a clear resection of the primary tumour followed by adjuvant radio-(chemo)therapy in advanced stages remains the gold standard therapy for head neck squamous cell carcinoma [1–3]. Several former reports have emphasized the importance of clear surgical margins for recurrence-free and disease-specific survival [4–6]. In discussion however is the optimal width of surgical margins. Currently resection margins are mostly categorized in involved (<1mm),...περισσότερα »

Recurrent G12V pathogenic mutation in adenomatoid odontogenic tumours

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Recurrent G12V pathogenic mutation in adenomatoid odontogenic tumours: The adenomatoid odontogenic tumour (AOT) is a non-aggressive encapsulated tumour, being usually diagnosed in association with an unerupted permanent maxillary canine [1,2]. There are scarce reports of multiple AOTs [3–5] and a patient with Schimmelpenning syndrome (SS) with AOT was reported [6]. SS is characterized by sebaceous nevi, associated with ipsilateral abnormalities of the central nervous system, resulting from postzygotic autosomal dominant HRAS or KRAS lethal mutations that survive by somatic mosaicism...περισσότερα »

Rhinosinusal Inflammation and High Mobility Group Box 1 Protein: A New Target for Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Rhinosinusal Inflammation and High Mobility Group Box 1 Protein: A New Target for Therapy: *Background/Aims:* High mobility group box 1 (HMGB1) is a protein belonging to the class of damage-associated molecular pattern molecules, which activates innate immunity and powerful inflammatory factors. The aim of this review is to show the importance of HMGB1 in the pathogenesis of nasal inflammatory diseases and to suggest that inhibition of HMGB1 may be an innovative therapeutic target. *Methods:* We used immunohistochemistry to study whether HMGB1 increases in chronic rhinosinusitis wit...περισσότερα »

AOSpine Masters Series, Volume 4: Adult Spinal Deformities, Luiz Roberto Vialle, Lawrence G. Lenke, Kenneth M.C. Cheung. Thieme, New York, NY (2015)

Publication date: May 2016 Source:World Neurosurgery, Volume 89 Author(s): Daniel M. Sciubba from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/24ZzDvt via IFTTT

Family with hearing loss accompanied by compound heterozygous mutations in LOXHD1

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Clinical characteristics of a Japanese via Auris Nasus LarynxPublication date: Available online 10 March 2016*Source:*Auris Nasus LarynxAuthor(s): Shujiro B. Minami, Hideki Mutai, Kazunori Namba, Hirozazu Sakamoto, Tatsuo MatsunagaObjectiveTo report two novel LOXHD1 mutations, including missense mutations and the clinical features of the patients.MethodsWe studied a three-generation Japanese family with hearing loss. Targeted next-generation sequencing was used for genetic analysis. Conditional orientation response audiometry and pure tone audiometry were used to assess hearing. ...περισσότερα »

Er:Yag Laser Treatment of Simple Snorers in an Outpatient Setting

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 19 δευτερόλεπτα
Er:Yag Laser Treatment of Simple Snorers in an Outpatient Setting: *Objective:* Snoring occurs as a result of soft tissue vibration caused by a partial upper airway collapse during sleep. This study evaluated the effectiveness and potential adverse side effects associated with the use of a nonsurgical, erbium-doped yttrium aluminum garnet (Er:YAG) laser treatment for patients with snoring conditions. *Materials and Methods:* In total, 33 patients with different degrees of snoring were analyzed retrospectively. All patients received three NightLase™ Er:YAG laser treatments. Results w...περισσότερα »

An Imaging Study in Patients With Thyroid Cancer or Head and Neck Cancer With Pertechnetate Made in a Cyclotron (C-PERT)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
An Imaging Study in Patients With Thyroid Cancer or Head and Neck Cancer With Pertechnetate Made in a Cyclotron (C-PERT): *Conditions*: Thyroid Neoplasms; Head and Neck Neoplasms*Interventions*: Drug: C-PERT; Drug: G-PERT*Sponsors*: AHS Cancer Control Alberta; Cross Cancer InstituteDoctors at the Cross Cancer Institute have developed a new method of producing 99mTc Pertechnetate in a cyclotron unit. A study done at the Cross Cancer Institute in 2011 with ten patients using this imaging agent showed that it was safe and produced images with the same pattern as gener...περισσότερα »

Reference-Free Assessment of Speech Intelligibility Using Bispectrum of an Auditory Neurogram

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Reference-Free Assessment of Speech Intelligibility Using Bispectrum of an Auditory Neurogram: Sensorineural hearing loss occurs due to damage to the inner and outer hair cells of the peripheral auditory system. Hearing loss can cause decreases in audibility, dynamic range, frequency and temporal resolution of the auditory system, and all of these effects are known to affect speech intelligibility. In this study, a new reference-free speech intelligibility metric is proposed using 2-D neurograms constructed from the output of a computational model of the auditory periphery. The resp...περισσότερα »

Long-term Voice Outcomes of Early Thyroplasty for Unilateral Vocal Fold Paralysis Following Aortic Arch Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Long-term Voice Outcomes of Early Thyroplasty for Unilateral Vocal Fold Paralysis Following Aortic Arch Surgery: Objective:To describe this institution’s experience with and the long-term outcomes of early type 1 thyroplasty for unilateral vocal fold paralysis (UVFP) following surgery on the aortic arch.Study Design:Retrospective chart review with telephone questionnaire.Setting:Academic tertiary care center.Subjects and Methods:Three hundred forty-eight patients with UVFP following surgery on the aortic arch since 1999 were identified; 40 were available for follow-up. Th...περισσότερα »

Compound Motor Action Potential Quantifies Recurrent Laryngeal Nerve Innervation in a Canine Model

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Compound Motor Action Potential Quantifies Recurrent Laryngeal Nerve Innervation in a Canine Model: Objective:The compound motor action potential (CMAP) is the summated action potential from multiple muscle fibers activated by a single nerve impulse. The utility of laryngeal muscle CMAP for quantifying innervation following recurrent laryngeal nerve (RLN) injury was investigated.Method:In a series of 21 canine hemi-laryngeal preparations, RLNs were exposed and a stimulating electrode placed. Maximum CMAP amplitudes and area under the curve from the thyroarytenoid (TA) muscles we...περισσότερα »

Effects of steam inhalation on voice quality-related acoustic measures

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Effects of steam inhalation on voice quality-related acoustic measures: Objectives/HypothesisTo investigate the effects of steam inhalation using a facial steamer on voice quality-related acoustic measures.Study DesignProspective outcome research: single-blinded experimental study.MethodsForty-five vocally healthy female subjects ranging in age from 18 to 30 years (Mean age: 22.41 years; standard deviation [SD]: 8.91) participated in the study. Phonation samples were recorded under three different conditions in triplicate: baseline recording, immediately after mouth breathing (d...περισσότερα »

Bilateral vestibulopathy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Diverse clinical and laboratory manifestations of bilateral vestibulopathy: Objectives/HypothesisTo identify the clinical and laboratory characteristics of bilateral vestibulopathy (BVP) on the video head impulse test (vHIT).Study DesignRetrospective chart analysis.MethodsDuring 23 months, 1,789 patients with dizziness underwent vHIT in our tertiary referral hospital. Of these patients, 65 (3.6%) patients had bilaterally positive catch-up saccades. Based on the caloric test, 15 (group 1) had bilateral caloric weakness, 13 (group 2) had unilateral caloric weakness, and 37 (group ...περισσότερα »

Effect of vocal fold asymmetries on glottal flow

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Effect of vocal fold asymmetries on glottal flow: Objectives/HypothesisVoice disorders, such as unilateral vocal fold paralysis or paresis, and vocal fold scarring feature structural asymmetries of the vocal folds. Studies on how structural asymmetries affect voice has mostly been limited to computational simulations and experiments on mechanical models. The purpose of the current study is to examine the effects of asymmetries in left–right position, height, and length of the vocal folds on the intraglottal flow characteristics, as well as acoustics in the canine larynx model. Stu...περισσότερα »

Predictors of survival in parotid small cell carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Predictors of survival in parotid small cell carcinoma: A study of 344 cases: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisWe sought to better characterize patient, tumor, and long-term survival characteristics of parotid small cell carcinoma (SmCC) with the National Cancer Database (NCDB). Study DesignRetrospective database review.MethodsWe reviewed the NCDB (1998–2012) for all cases of parotid SmCC. Relevant demographic, tumor, and survival variables were extracted and analyzed. Cox multivariate regression was performed to identify prognosticators....περισσότερα »

External bioresorbable airway rigidification to treat refractory localized tracheomalacia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
External bioresorbable airway rigidification to treat refractory localized tracheomalacia: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisOur study evaluates the efficacy of extraluminal bioresorbable plates to treat refractory localized airway malacia in patients undergoing corrective surgery for complex multilevel laryngotracheal stenosis.Study DesignRetrospective case series. MethodsSecondary malacic airway segments were characterized (severity, site, type) by a dynamic transnasal flexible laryngotracheobronchoscopy before surgery. Extraluminal bior...περισσότερα »

Cutaneous facial defects

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
An innovative photographic database for cutaneous facial defects: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisTo construct an easy-to-use server-based database that stores photographs of patients undergoing reconstructive surgery for cutaneous facial defects and organizes them in a manner best suited for rapid search and education.Study DesignAn institutional review board-approved user-modifiable database was designed using OnBase software (Hyland Software Inc., Westlake, OH) to store both the photographs of patients undergoing reconstructive surgery ...περισσότερα »

Percutaneous steroid injection for treating benign vocal fold lesions: A prospective study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Long-term efficacy of percutaneous steroid injection for treating benign vocal fold lesions: A prospective study: Objectives/HypothesisThis study assessed the long-term efficacy and recurrence rates of percutaneous steroid injections (PSIs) for benign vocal fold lesions. Study DesignProspective clinical study.MethodsA prospective human clinical trial was performed from October 2008 to September 2014 at Soonchunhyang University Hospital, Bucheon, Korea. Percutaneous steroid injection was performed in 84 consecutive patients with small benign vocal fold lesions, such as vocal fold ...περισσότερα »

Clinical risk assessment model for pediatric obstructive sleep apnea

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Clinical risk assessment model for pediatric obstructive sleep apnea: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisTo develop a clinical risk prediction model that identifies children with obstructive sleep apnea (OSA) in a clinical setting by examining the symptoms, physical status, and OSA-18 questionnaire results.DesignSingle institutional, cross-sectional study.MethodsChildren aged 2 to 18 years with symptoms of OSA were enrolled. Pediatric OSA was diagnosed through full-night polysomnography. Clinical data, namely demographics, symptoms, OSA-18 ...περισσότερα »

Practice variations in voice treatment selection following vocal fold mucosal resection

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Practice variations in voice treatment selection following vocal fold mucosal resection: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisTo characterize initial voice treatment selection following vocal fold mucosal resection in a Medicare population.Study DesignRetrospective analysis of a large, nationally representative Medicare claims database.MethodsPatients with > 12 months of continuous Medicare coverage who underwent a leukoplakia- or cancer-related vocal fold mucosal resection (index) procedure during calendar years 2004 to 2009 were studied. T...περισσότερα »

First results of a novel adjustable-length ossicular reconstruction prosthesis in temporal bones

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
First results of a novel adjustable-length ossicular reconstruction prosthesis in temporal bones: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisThe performance of an ossicular replacement prosthesis (ORP) is influenced by its alignment and appropriate tension between the tympanic membrane and the stapes footplate. A novel ORP with a flexible element that potentially allows for length adjustment in situ is presented and tested for acoustic performance.Study DesignLaser Doppler vibrometry in fresh human cadaveric temporal bones was used to test the acou...περισσότερα »

Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Effect of saline inhalation on vocal fold epithelial morphology evaluated by optical coherence tomography: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/Hypothesis Examination of tissue structures by optical coherence tomography (OCT) has been shown to be useful on mucous membranes of the vocal folds, but so far its application to the human larynx has been limited because it is technically cumbersome and usually needs to be performed with sedation. Here a newly developed, noninvasive combined laryngoscopy and OCT procedure is described and its suitability for ambu...περισσότερα »

Propensity score analysis of endoscopic and open approaches to malignant paranasal and anterior skull base tumor outcomes

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Propensity score analysis of endoscopic and open approaches to malignant paranasal and anterior skull base tumor outcomes: Objectives/HypothesisMalignant sinonasal and skull base tumors are now being resected using an endoscopic technique, but there has been controversy regarding the oncologic safety of this approach. Various studies have compared the outcomes from endoscopic surgery to those from open techniques; however, all have been limited by substantial differences in the patient populations receiving each approach. In this study we compare outcomes of open and endoscopic te...περισσότερα »

The ototronix MAXUM middle ear implant for severe high-frequency sensorineural hearing loss: Preliminary results

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
The ototronix MAXUM middle ear implant for severe high-frequency sensorineural hearing loss: Preliminary results: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisTo report the preliminary results of the Ototronix MAXUM middle ear implant for treatment of severe high-frequency sensorineural hearing loss.Study DesignCase series with chart review.MethodsSix consecutive ears with severe high-frequency sensorineural hearing loss (≥75 dB HL at 2, 3, and 4 kHz) and poor aided word recognition performance (≤60% single words) underwent implantation of the MAXUM ...περισσότερα »

Sialendoscopy-assisted surgery and the chronic obstructive sialadenitis symptoms questionnaire: A prospective study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Sialendoscopy-assisted surgery and the chronic obstructive sialadenitis symptoms questionnaire: A prospective study: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisTo prospectively assess symptoms of obstructive sialadenitis before and after sialendoscopy-assisted salivary duct surgery (SASDS) using the chronic obstructive sialadenitis symptoms (COSS) questionnaire to determine and predict impact of interventions.Study DesignProspective cohort study.MethodsAdult patients with chronic obstructive sialadenitis who underwent SASDS were asked to complete ...περισσότερα »

The efficacy of combination therapy for idiopathic sudden sensorineural hearing loss

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
The efficacy of combination therapy for idiopathic sudden sensorineural hearing loss: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisThe aim of this study was to compare the hearing results of patients with idiopathic sudden sensorineural hearing loss (ISSNHL) who initially were treated with either a combination therapy of systemic steroids (SS) and intratympanic steroid injection (IT-S) or SS only.MethodsThe study followed a retrospective case-control design. One-hundred five patients who were diagnosed with ISSNHL and required treatment via admission...περισσότερα »

Nonstimulated rabbit phonation model: Cricothyroid approximation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 20 δευτερόλεπτα
Nonstimulated rabbit phonation model: Cricothyroid approximation: [image: cover.gif?v=1&s=91b5c09aa476055defd12367]Objectives/HypothesisTo describe a nonstimulated in vivo rabbit phonation model using an Isshiki type IV thyroplasty and uninterrupted humidified glottal airflow to produce sustained audible phonation.Study DesignProspective animal study.MethodsSix New Zealand white breeder rabbits underwent a surgical procedure involving an Isshiki type IV thyroplasty and continuous airflow delivered to the glottis. Phonatory parameters were examined using high-speed laryngeal...περισσότερα »

Cancers, Vol. 8, Pages 35: Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 22 δευτερόλεπτα
Tumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of proteins between the nucleus and cytoplasm is complex. It occurs through nuclear pores and exported proteins need a nuclear export signal (NES) to bind to nuclear exportin proteins, including CRM1 (Chromosomal Region Maintenance protein 1), and the energy for this process is provided by the RanGTP/RanGDP gradient. Due to the loss of DNA repa...περισσότερα »

Acute trauma factor associations with suicidality across the first 5 years after traumatic brain injury

Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Publication date: Available online 14 March 2016 *Source:*Archives of Physical Medicine and RehabilitationAuthor(s): Matthew R. Kesinger, Shannon B. Juengst, Hillary Bertisch, Janet P. Niemeier, Jason W. Krellman, Mary Jo Pugh, Raj G. Kumar, Jason L. Sperry, Patricia M. Arenth, Jesse R. Fann, Amy K. WagnerObjectiveTo determine whether severities of head and extra-cranial injuries (ECI) were associated with suicidal ideation (SI) or suicide attempt (SA) after traumatic brain injury (TBI).DesignFactors associated with SI and SA were assessed in this inception cohort study using data ...περισσότερα »

Toxics, Vol. 4, Pages 7: Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in a Mexican-American Cohort: Variability in Early and Late Pregnancy

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
People are exposed to phthalates through their wide use as plasticizers and in personal care products. Many phthalates are endocrine disruptors and have been associated with adverse health outcomes. However, knowledge gaps exist in understanding the molecular mechanisms associated with the effects of exposure in early and late pregnancy. In this study, we examined the relationship of eleven urinary phthalate metabolites with isoprostane, an established marker of oxidative stress, among pregnant Mexican-American women from an agricultural cohort. Isoprostane levels were on average 2...περισσότερα »

Atmosphere, Vol. 7, Pages 45: Soot Nanoparticles Could Partake in Nucleation of Biogenic Particles in the Atmosphere: Using Fullerene as a Model Compound

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
The detection of existence of fullerenes (C60 and C70) makes it necessary to explore whether soot nanoparticles can participate in new nanometer-sized particle formation and growth in the atmosphere. This study describes a theoretical investigation at multiple levels on the role of the fullerenes (as model compounds to represent nanoparticles of soot) in the formation of complexes with a common atmospheric nucleating precursor (sulfuric acid, SA) and a biogenic organic acid (cis-pinonic acid, CPA), as well as initial growth of nano-sized biogenic aerosols. Quantum chemical density...περισσότερα »

Micromachines, Vol. 7, Pages 48: Experimental Analysis of Porosity and Permeability in Pressed Paper

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
In this paper, we report an analysis of pressed paper in terms of porosity and permeability. Previously, we reported a pressed paper that exhibits decreased porosity and permeability. Additionally, its applications into programmed sample delivery as well as flow rate control were reported. However, there is a need for a theoretical analysis of pressed paper in terms of porosity and permeability for a more precise design principle and its applications because porosity and permeability are important factors in determining fluidic behavior. Here, we propose a theoretical model for an...περισσότερα »

Acute trauma factor associations with suicidality across the first 5 years after traumatic brain injury

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Publication date: Available online 14 March 2016 *Source:*Archives of Physical Medicine and RehabilitationAuthor(s): Matthew R. Kesinger, Shannon B. Juengst, Hillary Bertisch, Janet P. Niemeier, Jason W. Krellman, Mary Jo Pugh, Raj G. Kumar, Jason L. Sperry, Patricia M. Arenth, Jesse R. Fann, Amy K. WagnerObjectiveTo determine whether severities of head and extra-cranial injuries (ECI) were associated with suicidal ideation (SI) or suicide attempt (SA) after traumatic brain injury (TBI).DesignFactors associated with SI and SA were assessed in this inception cohort study using data ...περισσότερα »

Serum uric acid levels during leprosy reaction episodes

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Background. Leprosy reactions are acute inflammatory episodes that occur mainly in the multibacillary forms of the disease. The reactions are classified as type 1 (reverse reaction) or type 2 (erythema nodosum leprosum). Leprosy-associated oxidative stress has been widely demonstrated. Several recent studies have shown uric acid (UA) to have antioxidative effects under pathologic conditions. The objective of this study was to assess serum levels of UA in patients with leprosy reactions, with the aim of monitoring their levels before and after treatment, compared with levels in lep...περισσότερα »

Reproductive biology of the biofuel plant Jatropha curcas in its center of origin

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
In this work, we studied the main characteristics of flowering, reproductive system and diversity of pollinators for the biofuel plant Jatropha curcas (L.) in a site of tropical southeastern Mexico, within its center of origin. The plants were monoecious with inflorescences of unisexual flowers. The male flowers produced from 30625016 pollen grains (266–647 per anther). The plants produced fruits with both geitonogamy and xenogamy, although insect pollination significantly increased the number and quality of fruits. A high diversity of flower visiting insects (36 species) was foun...περισσότερα »

Reducing bias in population and landscape genetic inferences: the effects of sampling related individuals and multiple life stages

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
In population or landscape genetics studies, an unbiased sampling scheme is essential for generating accurate results, but logistics may lead to deviations from the sample design. Such deviations may come in the form of sampling multiple life stages. Presently, it is largely unknown what effect sampling different life stages can have on population or landscape genetic inference, or how mixing life stages can affect the parameters being measured. Additionally, the removal of siblings from a data set is considered best-practice, but direct comparisons of inferences made with and wit...περισσότερα »

The effect of ribosomal protein S15a in lung adenocarcinoma

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Background: RPS15A (Ribosomal Protein S15A) promotes mRNA/ribosome interactions in translation. It is critical for the process of eukaryotic protein biosynthesis. Recently, aberrantly expressed RPS15A was found in the hepatitis virus and in malignant tumors. However, the role of RPS15A has not been fully revealed on the development of lung cancer. Method: In this study, a Tissue Microarray (TMA) of primary lung adenocarcinoma tissue specimens was carried out. Furthermore, to further investigate the function of RPS15A in lung cancer, RPS15A-specific short hairpin RNA (shRNA) expres...περισσότερα »

The role of sex and age in the architecture of intrapopulation howler monkey-plant networks in continuous and fragmented rain forests

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
We evaluated the structure of intrapopulation howler monkey-plant interactions by focusing on the plant species consumed by different sex and age classes in continuous and fragmented forests in southern Mexico. For this we used network analysis to evaluate the impact of fragmentation on howler population traits and on resource availability and food choice. A total of 37 tree and liana species and seven plant items (bark, immature fruits, flowers, mature fruits, immature leaves, mature leaves and petioles) were consumed, but their relative consumption varied according to sex and ag...περισσότερα »

Palatability and pharmacokinetics of flunixin when administered to sheep through feed

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Applying analgesics to feed is a potentially easy method of providing pain-relief to sheep and lambs that undergo painful husbandry procedures. To be effective, the medicated feed needs to be readily accepted by sheep and its consumption needs to result in therapeutic concentrations of the drug. In the present experiment, pelleted feed was supplemented with flunixin (4.0 mg/kg live weight) and offered to eight sheep. To test the palatability of flunixin, the individually penned sheep were offered normal feed and feed supplemented with flunixin in separate troughs for two consecuti...περισσότερα »

A new species of Psychrophrynella (Amphibia, Anura, Craugastoridae) from the humid montane forests of Cusco, eastern slopes of the Peruvian Andes

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
We describe a new species of Psychrophrynella from the humid montane forest of the Department Cusco in Peru. Specimens were collected at 2,670–3,165 m elevation in the Área de Conservación Privada Ukumari Llakta, Japumayo valley, near Comunidad Campesina de Japu, in the province of Paucartambo. The new species is readily distinguished from all other species of Psychrophrynella but P. bagrecito and P. usurpator by possessing a tubercle on the inner edge of the tarsus, and from these two species by its yellow ventral coloration on abdomen and limbs. Furthermore, the new species is l...περισσότερα »

Scientific publications in nursing journals from Mainland China, Taiwan, and Hong Kong: a 10-year survey of the literature

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Background: China has witnessed remarkable progress in scientific performance in recent years. However, the quantity and quality of nursing publications from three major regions (Mainland China, Taiwan, and Hong Kong) have not been reported. This study aimed to investigate the characteristics of scientific research productivity from Mainland China, Taiwan, and Hong Kong in the field of nursing. Methods: Articles published in the 110 nursing journals originating from Mainland China, Taiwan, and Hong Kong between 2005 and 2014 were retrieved from the Web of Science. The total number...περισσότερα »

ColoFinder: a prognostic 9-genes signature improve prognosis for 871 stage II and III colorectal cancer patients

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Colorectal cancer (CRC) is the heterogeneous disease with a high mortality rate, and still lacks an effective treatment. Our goal is to develop a robust prognosis model for predicting the prognosis in CRC patients. In this study, 871 stage II and III CRC samples were collected from six gene expression profilings. ColoFinder was developed using 9-genes signature based Random Survival Forest (RSF) prognosis model. The 9-genes signature recurrence score was derived with 5-fold cross validation to test the association with relapse-free survival and the value of AUC was gained with 0.8...περισσότερα »

Computational inference of H3K4me3 and H3K27ac domain length

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Background. Recent epigenomic studies have shown that the length of a DNA region covered by an epigenetic mark is not just a byproduct of the assaying technologies and has functional implications for that locus. For example, expanded regions of DNA sequences that are marked by enhancer-specific histone modifications, such as acetylation of histone H3 lysine 27 (H3K27ac) domains coincide with cell-specific enhancers, known as super or stretch enhancers. Similarly, promoters of genes critical for cell-specific functions are marked by expanded H3K4me3 domains in the cognate cell type...περισσότερα »

Biosensors, Vol. 6, Pages 8: Aryl Diazonium Chemistry for the Surface Functionalization of Glassy Biosensors

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Nanostring resonator and fiber-optics-based biosensors are of interest as they offer high sensitivity, real-time measurements and the ability to integrate with electronics. However, these devices are somewhat impaired by issues related to surface modification. Both nanostring resonators and photonic sensors employ glassy materials, which are incompatible with electrochemistry. A surface chemistry approach providing strong and stable adhesion to glassy surfaces is thus required. In this work, a diazonium salt induced aryl film grafting process is employed to modify a novel SiCN gla...περισσότερα »

A hepatitis C virus envelope polymorphism confers resistance to neutralization by polyclonal sera and broadly neutralizing monoclonal antibodies

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Journal of Virologyfrom #Medicine via ola Kala on Inoreader http://ift.tt/1pGbASevia IFTTT

Efficacy of direct-acting antiviral combination for patients with HCV genotype 1 infection and severe renal impairment or end-stage renal disease

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Gastroenterologyfrom #Medicine via ola Kala on Inoreader http://ift.tt/22f0nWKvia IFTTT

Elevated serum gamma-glutamyltransferase predicts advanced histological liver damage in chronic hepatitis b

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Discovery Medicinefrom #Medicine via ola Kala on Inoreader http://ift.tt/1pGbAS8via IFTTT

Colectomy rates in patients with ulcerative colitis following treatment with infliximab or ciclosporin: a systematic literature review

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
European Journal of Gastroenterology & Hepatologyfrom #Medicine via ola Kala on Inoreader http://ift.tt/22f0nWwvia IFTTT

Multidrug resistance protein 4 is a critical protein associated with the antiviral efficacy of nucleos(t)ide analogues

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 22 δευτερόλεπτα
Liver Internationalfrom #Medicine via ola Kala on Inoreader http://ift.tt/1pGbARXvia IFTTT

AOSpine Masters Series, Volume 4: Adult Spinal Deformities, Luiz Roberto Vialle, Lawrence G. Lenke, Kenneth M.C. Cheung. Thieme, New York, NY (2015)

Alexandros G. SfakianakisστοΝευρολογία κ' ΝευροχειρουργικήΠριν από 24 δευτερόλεπτα
[image: alertIcon.gif]Publication date: May 2016 *Source:*World Neurosurgery, Volume 89Author(s): Daniel M. Sciubbafrom Neurology via xlomafota13 on Inoreader http://ift.tt/24ZzDvtvia IFTTT

Interactions of subglottal pressure and neuromuscular activation on fundamental frequency and intensity

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Interactions of subglottal pressure and neuromuscular activation on fundamental frequency and intensity: Objectives/HypothesisFundamental frequency (F0) and intensity sound pressure level (SPL) of voice are controlled by intrinsic laryngeal muscle (ILM) activation and subglottal pressure (Psub). Their interactions were investigated. MethodsIn an in vivo canine model, the thyroarytenoid (TA), lateral cricoarytenoid/interarytenoid (LCA/IA), and cricothyroid (CT) muscles were independently activated from threshold to maximal contraction by neuromuscular stimulation in various combina...περισσότερα »

Necrotizing Periodontal Diseases in Children

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Necrotizing Periodontal Diseases in Children: A Literature Review and Adjustment of Treatment.:J Trop Pediatr. 2016 Mar 10; Authors: Marty BM, Palmieri J, Noirrit-Esclassan E, Vaysse F, Bailleul-Forestier IAbstractNecrotizing ulcerative gingivitis, sometimes observed in young children, may lead to necrotizing stomatitis and noma. Therefore, its interception is a necessity and a challenge for the paediatric practitioners. First, this article aims to propose a systematic review of recent literature on the use of local antiseptic and antibiotic prescription in this particular per...περισσότερα »

Postoperative Oral Fluid Intake as a Predictor of Postoperative Emergency Department Visits After Pediatric Tonsillectomy.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 28 δευτερόλεπτα
Investigation of Postoperative Oral Fluid Intake as a Predictor of Postoperative Emergency Department Visits After Pediatric Tonsillectomy.:JAMA Otolaryngol Head Neck Surg. 2016 Mar 10;Authors: Rohlfing ML, Wistermayer PR, Bungo TM, Mims JW, Kirse DJAbstractImportance: This study contributes novel data on the association between oral fluid intake before discharge and adverse outcomes following tonsillectomy in pediatric patients. These data contribute to evidence-based, safe, and cost-effective decision making regarding discharge.Objective: To determine whether the quantity o...περισσότερα »

Hearing preservation technique in cochlear implant

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
Outcomes review of modern via Auris Nasus Larynx Publication date: Available online 11 March 2016*Source:*Auris Nasus Larynx Author(s): Sally Nguyen, François Cloutier, Daniel Philippon, Mathieu Côté, Richard Bussières, Douglas D. BackousIntroductionPreservation of residual hearing in cochlear implantation is a main concern for patients and otologists. New electrode arrays as well as development of minimally invasive technique have allowed the expansion of indication criteria for cochlear implantation. The loss of residual low-frequency hearing is thought to be the result of many fa...περισσότερα »

High-speed digital imaging : Vocal-fold vibration of patients with Reinke's edema

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
observed using high-speed digital imagingvia Auris Nasus LarynxPublication date: Available online 11 March 2016*Source:*Auris Nasus LarynxAuthor(s): Takeshi Watanabe, Kenichi Kaneko, Koichi Sakaguchi, Haruo TakahashiObjectiveWe aimed to assess the vocal-fold vibration of patients with moderate-to-severe Reinke's edema using high-speed digital imaging (HSDI) and videostroboscopy and to confirm HSDI usefulness in examining the vocal folds with Reinke's edema.MethodsWe examined the vocal folds of seven patients (six severe and one moderate; six females and one male; aged 55–74 year...περισσότερα »

Predictors of overall survival in human papillomavirus-associated oropharyngeal cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 29 δευτερόλεπτα
using the National Cancer Data Basevia ScienceDirect Publication: Oral OncologyPublication date: May 2016*Source:*Oral Oncology, Volume 56Author(s): Arya Amini, Jagar Jasem, Bernard L. Jones, Tyler P. Robin, Jessica D. McDermott, Shilpa Bhatia, David Raben, Antonio Jimeno, Daniel W. Bowles, Sana D. KaramObjectivesThis study identifies clinical characteristics associated with HPV-positive oropharynx squamous cell carcinoma (OPSCC) and evaluates predictors of overall survival (OS) in HPV-positive patients undergoing definitive treatment within the National Cancer Data Base (NCDB).Ma...περισσότερα »

Biosensors, Vol. 6, Pages 8: Aryl Diazonium Chemistry for the Surface Functionalization of Glassy Biosensors

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 31 δευτερόλεπτα
Nanostring resonator and fiber-optics-based biosensors are of interest as they offer high sensitivity, real-time measurements and the ability to integrate with electronics. However, these devices are somewhat impaired by issues related to surface modification. Both nanostring resonators and photonic sensors employ glassy materials, which are incompatible with electrochemistry. A surface chemistry approach providing strong and… Continue reading Biosensors, Vol. 6, Pages 8: Aryl Diazonium Chemistry for the Surface Functionalization of Glassy Biosensors

Kronisk utmattelsessyndrom og erfaring med «Lightning Process»

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 31 δευτερόλεπτα
Årsaken til ME er uavklart og omstridt, og behandlingsmulighetene er begrensede, men mange som har deltatt på kurset Lightning Process har rapportert om positiv effekt. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1pp8ulw via IFTTT

Cancers, Vol. 8, Pages 35: Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 31 δευτερόλεπτα
Tumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of proteins between the nucleus and cytoplasm is complex. It occurs through nuclear pores and exported proteins… Continue reading Cancers, Vol. 8, Pages 35: Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy

Recurrent KRAS G12V pathogenic mutation in adenomatoid odontogenic tumours

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
*Recurrent KRAS G12V pathogenic mutation in adenomatoid odontogenic tumours**via ScienceDirect Publication: Oral Oncology* *Publication date: Available online 12 March 2016Source:Oral OncologyAuthor(s): Carolina Cavalieri Gomes, Sílvia Ferreira de Sousa, Grazielle Helena Ferreira de Menezes, Alessandra Pires Duarte, Thaís dos Santos Fontes Pereira, Rennan Garcia Moreira, Wagner Henriques de Castro, Rolando A.R. Villacis, Silvia Regina Rogatto, Marina Gonçalves Diniz, Ricardo Santiago Gomez**[HTML] από nih.gov* *Recurrent *GNAS *mutations *define an unexpected pathway for pancreati...περισσότερα »

Epidemiology of Low-Risk Human Papillomavirus

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 31 δευτερόλεπτα
Epidemiology of Low-Risk Human Papillomavirus: AbstractInfection with low-risk human papillomaviruses (HPVs), mostly type 6 and 11, in the upper respiratory tract causes recurrent respiratory papillomatosis (RRP). Despite a relatively low incidence rate, RRP imposes significant morbidity upon affected patients and an enormous financial burden on the healthcare system. RRP can be further categorized into juvenile-onset RRP and adult-onset RRP, depending on the onset age. They may associate with different risk factors and incidence rates. Here, we review the epidemiology of RRP cause...περισσότερα »

Acute trauma factor associations with suicidality across the first 5 years after traumatic brain injury

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Publication date: Available online 14 March 2016 *Source:*Archives of Physical Medicine and RehabilitationAuthor(s): Matthew R. Kesinger, Shannon B. Juengst, Hillary Bertisch, Janet P. Niemeier, Jason W. Krellman, Mary Jo Pugh, Raj G. Kumar, Jason L. Sperry, Patricia M. Arenth, Jesse R. Fann, Amy K. WagnerObjectiveTo determine whether severities of head and extra-cranial injuries (ECI) were associated with suicidal ideation (SI) or suicide attempt (SA) after traumatic brain injury (TBI).DesignFactors associated with SI and SA were assessed in this inception cohort study using data ...περισσότερα »

Elevated serum gamma-glutamyltransferase predicts advanced histological liver damage in chronic hepatitis b

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Discovery Medicinefrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1pGbAS8via IFTTT

Colectomy rates in patients with ulcerative colitis following treatment with infliximab or ciclosporin: a systematic literature review

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
European Journal of Gastroenterology & Hepatologyfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/22f0nWwvia IFTTT

Multidrug resistance protein 4 is a critical protein associated with the antiviral efficacy of nucleos(t)ide analogues

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Liver Internationalfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1pGbARXvia IFTTT

Shedding of hepatitis C virus in semen of HIV-infected men

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Open Forum Infectious Diseasesfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/22f0lOqvia IFTTT

Utility of a molecular pre-screening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Annals of Oncologyfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1pGbABzvia IFTTT

Prevalence, characteristics, and survival of children with esophageal atresia: A 32-year population-based study including 1,417,724 consecutive newborns

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Birth Defects Research Part A: Clinical and Molecular Teratologyfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/22f0ktTvia IFTTT

Patient-reported outcomes in Asian patients with chronic hepatitis c treated with ledipasvir and sofosbuvir

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Medicinefrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1pGbABvvia IFTTT

Confocal laser endomicroscopy in ulcerative colitis: a longitudinal study of endomicroscopic changes and response to medical therapy

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Gastrointestinal Endoscopyfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/22f0l14via IFTTT

Faecal chitinase 3-like 1 is a reliable marker as accurate as faecal calprotectin in detecting endoscopic activity in adult patients with inflammatory bowel diseases

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Alimentary Pharmacology and Therapeuticsfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1pGbzh3via IFTTT

Diabetic biomarkers and the risk of proximal or distal gastric cancer

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Journal of Gastroenterology and Hepatologyfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1pGbxpwvia IFTTT

Coeliac disease in adolescence: Coping strategies and personality factors affecting compliance with gluten-free diet

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Appetitefrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/22f0hOMvia IFTTT

Should surveillance for liver cancer be modified in hepatitis C patients after treatment-related cirrhosis regression?

AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 33 δευτερόλεπτα
Liver Internationalfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1pGbz0Avia IFTTT

Defining the Surgical Limits of Adenoidectomy so as to Prevent Recurrence of Adenoids

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Defining the Surgical Limits of Adenoidectomy so as to Prevent Recurrence of Adenoids: AbstractThis study aims to define the surgical boundaries of adenoidectomy by demonstrating that recurrence of adenoids and its symptoms can be avoided if a complete adenoidectomy is performed, by following these surgical limits. A prospective descriptive study was carried out at Speciality ENT Hospital, Mumbai, India. Endoscopic adenoidectomy was performed in 83 patients using coblation technology. In all patients, adenoids were removed superiorly till the periosteum over the body of sphenoid; ...περισσότερα »

Voluminous Myoepithelioma of the Minor Salivary Glands Involving the Base of the Tongue

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Voluminous Myoepithelioma of the Minor Salivary Glands Involving the Base of the Tongue: Myoepithelioma is an extremely rare tumour subtype and diagnosis is based on a wide variation of cellular morphology. FNAC specimens do not always suffice for a definitive differential diagnosis which depends on histology and immunohistochemistry of the lesion. Case Presentation. A 54-year-old female came to our attention with dysphagia and dyslalia of 6-month standing. Ear, Nose, and Throat (ENT) examination revealed a voluminous mass on the right portion of the base of her tongue, where postco...περισσότερα »

Effect of Preoperative Nerve Block on Postthyroidectomy Headache and Cervical Pain: A Randomized Prospective Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Effect of Preoperative Nerve Block on Postthyroidectomy Headache and Cervical Pain: A Randomized Prospective Study: The aim of the current study was to investigate the efficacy of greater occipital nerve (GON) block and bilateral superficial cervical plexuses (BSCP) blocks in alleviating postoperative occipital headache and posterior neck pain after thyroidectomy. This randomized prospective study consisted of 75 women undergoing total thyroidectomy. Patients were randomized into three groups: Group I (): patients receiving GON, Group II (): patients receiving bilateral (BSCP) block...περισσότερα »

Significance of Interleukin-6 in Papillary Thyroid Carcinoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 33 δευτερόλεπτα
Significance of Interleukin-6 in Papillary Thyroid Carcinoma: This study sought to reveal the significance of IL-6 in papillary thyroid carcinoma by determining its circulating levels, tumoral protein, and mRNA expressions. As compared to the healthy individuals, serum IL-6 was significantly higher in patients with benign thyroid diseases and PTC. Further, its level was significantly higher in PTC patients as compared to patients with benign thyroid diseases. ROC curves also confirmed a good discriminatory efficacy of serum IL-6 between healthy individuals and patients with benign th...περισσότερα »

Chronic Periodontitis and Erectile Dysfunction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 34 δευτερόλεπτα
Relationship between Chronic Periodontitis and Erectile Dysfunction: A Narrative Review: Objective. To conduct a descriptive literature review on research studies investigating the association between chronic periodontitis (CP) and erectile dysfunction (ED). Methods. Cohort studies, case-control studies, cross-sectional studies, randomized control trials, and animal studies up to July 2015 that studied the relationship between CP and ED were reviewed and reported. Data sources included PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov. The themes “periodontal disease” and “er...περισσότερα »

AOSpine Masters Series, Volume 4: Adult Spinal Deformities, Luiz Roberto Vialle, Lawrence G. Lenke, Kenneth M.C. Cheung. Thieme, New York, NY (2015)

Publication date: May 2016 Source:World Neurosurgery, Volume 89 Author(s): Daniel M. Sciubba from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/24ZzDvt via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Kronisk utmattelsessyndrom og erfaring med «Lightning Process»

Årsaken til ME er uavklart og omstridt, og behandlingsmulighetene er begrensede, men mange som har deltatt på kurset Lightning Process har rapportert om positiv effekt. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1pp8ulw via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Cancers, Vol. 8, Pages 35: Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy

Tumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of proteins between the nucleus and cytoplasm is complex. It occurs through nuclear pores and exported proteins […]

Cancers, Vol. 8, Pages 35: Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy

Tumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of proteins between the nucleus and cytoplasm is complex. It occurs through nuclear pores and exported proteins […]

Acute trauma factor associations with suicidality across the first 5 years after traumatic brain injury

Publication date: Available online 14 March 2016 Source:Archives of Physical Medicine and Rehabilitation Author(s): Matthew R. Kesinger, Shannon B. Juengst, Hillary Bertisch, Janet P. Niemeier, Jason W. Krellman, Mary Jo Pugh, Raj G. Kumar, Jason L. Sperry, Patricia M. Arenth, Jesse R. Fann, Amy K. Wagner ObjectiveTo determine whether severities of head and extra-cranial injuries […]

Hospitals and GPs are offered incentives to reduce antibiotic prescribing

GPs and hospitals in England will be given incentives to reduce the number of antibiotics they prescribe, in an effort to tackle the growing problem of antibiotic resistance.NHS England announced… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QXlMfV via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Rates of prophylactic mastectomy triple in decade, study shows

The rates of prophylactic mastectomy more than tripled from 2002 to 2012 in a US cohort of women with invasive breast cancer despite this option offering no significant survival benefit over breast… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1V5VoFJ via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

IJERPH, Vol. 13, Pages 313: Exploring Associations between Problematic Internet Use, Depressive Symptoms and Sleep Disturbance among Southern Chinese Adolescents

The primary aim of this study was to examine associations between problematic Internet use, depression and sleep disturbance, and explore whether there were differential effects of problematic Internet use and depression on sleep disturbance. A total of 1772 adolescents who participated in the Shantou Adolescent Mental Health Survey were recruited in 2012 in Shantou, China. […]

Viruses, Vol. 8, Pages 79: Characterization of Intra-Type Variants of Oncogenic Human Papillomaviruses by Next-Generation Deep Sequencing of the E6/E7 Region

Different human papillomavirus (HPV) types are characterized by differences in tissue tropism and ability to promote cell proliferation and transformation. In addition, clinical and experimental studies have shown that some genetic variants/lineages of high-risk HPV (HR-HPV) types are characterized by increased oncogenic activity and probability to induce cancer. In this study, we designed and validated […]

BacterioFiles 243 – Fungal Friends Facilitate Phytoextraction (feat. Cat Adams)

This episode: A conversation with Cat Adams about how fungi help plants clean up toxic zinc nanoparticles in soil! (14.6 MB, 16 minutes) Show notes: from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1SLX0Uu via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Acute trauma factor associations with suicidality across the first 5 years after traumatic brain injury

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Publication date: Available online 14 March 2016 *Source:*Archives of Physical Medicine and RehabilitationAuthor(s): Matthew R. Kesinger, Shannon B. Juengst, Hillary Bertisch, Janet P. Niemeier, Jason W. Krellman, Mary Jo Pugh, Raj G. Kumar, Jason L. Sperry, Patricia M. Arenth, Jesse R. Fann, Amy K. WagnerObjectiveTo determine whether severities of head and extra-cranial injuries (ECI) were associated with suicidal ideation (SI) or suicide attempt (SA) after traumatic brain injury (TBI).DesignFactors associated with SI and SA were assessed in this inception cohort study using data ...περισσότερα »

Pathologic Fracture in Osteosarcoma: Association with poorer overall survival

Publication date: Available online 14 March 2016 Source:European Journal of Surgical Oncology (EJSO) Author(s): Abhijeet Ashok Salunke, Jaymin Shah, Nayan Gupta, Jyotindra Pandit from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1RZgine via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Cancers, Vol. 8, Pages 35: Mechanisms of Nuclear Export in Cancer and Resistance to Chemotherapy

Tumour suppressor proteins, such as p53, BRCA1, and ABC, play key roles in preventing the development of a malignant phenotype, but those that function as transcriptional regulators need to enter the nucleus in order to function. The export of proteins between the nucleus and cytoplasm is complex. It occurs through nuclear pores and exported proteins […]

Algorithms, Vol. 9, Pages 20: The Iterative Solution to Discrete-Time H∞ Control Problems for Periodic Systems

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
This paper addresses the problem of solving discrete-time H ∞ control problems for periodic systems. The approach for solving such a type of equations is well known in the literature. However, the focus of our research is set on the numerical computation of the stabilizing solution. In particular, two effective methods for practical realization of the known iterative processes are described. Furthermore, a new iterative approach is investigated and applied. On the basis of numerical experiments, we compare the presented methods. A major conclusion is that the new iterative approac...περισσότερα »

Atmosphere, Vol. 7, Pages 43: Reconstructing Fire Records from Ground-Based Routine Aerosol Monitoring

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Long-term fire records are important to understanding the trend of biomass burning and its interactions with air quality and climate at regional and global scales. Traditionally, such data have been compiled from ground surveys or satellite remote sensing. To obtain aerosol information during a fire event to use in analyzing air quality, we propose a new method of developing a long-term fire record for the contiguous United States using an unconventional data source: ground-based aerosol monitoring. Assisted by satellite fire detection, the mass concentration, size distribution, an...περισσότερα »

Energies, Vol. 9, Pages 194: Predictive Control Applied to a Solar Desalination Plant Connected to a Greenhouse with Daily Variation of Irrigation Water Demand

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
The water deficit in the Mediterranean area is a known matter severely affecting agriculture. One way to avoid the aquifers' exploitation is to supply water to crops by using thermal desalination processes. Moreover, in order to guarantee long-term sustainability, the required thermal energy for the desalination process can be provided by solar energy. This paper shows simulations for a case study in which a solar multi-effect distillation plant produces water for irrigation purposes. Detailed models of the involved systems are the base of a predictive controller to operate the de...περισσότερα »

Animals, Vol. 6, Pages 21: Updating Animal Welfare Thinking: Moving beyond the “Five Freedoms” towards “A Life Worth Living”

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
The Five Freedoms have had major impact on animal welfare thinking internationally. However, despite clear initial statements that the words 'freedom from' should indicate 'as free as possible from', the Freedoms have come to be represented as absolute or fundamental freedoms, even rights, by some animal advocate and other groups. Moreover, a marked increase in scientific understanding over the last two decades shows that the Freedoms do not capture the more nuanced knowledge of the biological processes that is germane to understanding animal welfare and which is now available to ...περισσότερα »

Algorithms, Vol. 9, Pages 19: Review of Recent Advances in the Application of the Wavelet Transform to Diagnose Cracked Rotors

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Wavelet transform (WT) has been used in the diagnosis of cracked rotors since the 1990s. At present, WT is one of the most commonly used tools to treat signals in several fields. Understandably, this has been an area of extensive scientific research, which is why this paper aims to summarize briefly the major advances in the field since 2008. The present review considers advances in the use and application of WT, the selection of the parameters used, and the key achievements in using WT for crack diagnosis.from #Medicine via ola Kala on Inoreader http://ift.tt/1QQPXqZMedicine by ...περισσότερα »

Remote Sensing, Vol. 8, Pages 241: Monitoring Riverbank Erosion in Mountain Catchments Using Terrestrial Laser Scanning

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Sediment yield is a key factor in river basins management due to the various and adverse consequences that erosion and sediment transport in rivers may have on the environment. Although various contributions can be found in the literature about sediment yield modeling and bank erosion monitoring, the link between weather conditions, river flow rate and bank erosion remains scarcely known. Thus, a basin scale assessment of sediment yield due to riverbank erosion is an objective hard to be reached. In order to enhance the current knowledge in this field, a monitoring method based on...περισσότερα »

Shedding of hepatitis C virus in semen of HIV-infected men

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Open Forum Infectious Diseasesfrom #Medicine via ola Kala on Inoreader http://ift.tt/22f0lOqvia IFTTT

Utility of a molecular pre-screening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Annals of Oncologyfrom #Medicine via ola Kala on Inoreader http://ift.tt/1pGbABzvia IFTTT

Prevalence, characteristics, and survival of children with esophageal atresia: A 32-year population-based study including 1,417,724 consecutive newborns

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Birth Defects Research Part A: Clinical and Molecular Teratologyfrom #Medicine via ola Kala on Inoreader http://ift.tt/22f0ktTvia IFTTT

Patient-reported outcomes in Asian patients with chronic hepatitis c treated with ledipasvir and sofosbuvir

Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 1 ώρα
Medicinefrom #Medicine via ola Kala on Inoreader http://ift.tt/1pGbABvvia IFTTT

Safety of Intra-arterial Catheter Directed Thrombolysis: Does Level of Care Matter?

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Publication date: Available online 14 March 2016 *Source:*European Journal of Vascular and Endovascular SurgeryAuthor(s): L. Koraen-Smith, M. Wängberg, C. Montán, P. Gillgren, C.-M. WahlgrenObjectivesThe aim was to assess whether the level of care influenced the safety related outcomes of catheter directed thrombolysis (CDT) for patients presenting with limb ischaemia and dialysis access thrombosis.MethodsThis was a retrospective cohort study. All consecutive patients at two tertiary referral centres for vascular surgery undergoing CDT for limb ischaemia and dialysis access thromb...περισσότερα »

20Q: Tinnitus and Hyperacusis - Beyond the Ear

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα
As auditory neuroscientists, we are mainly concerned with the way in which the different dimensions of sound (e.g., intensity, frequency and time) activate specific regions of the peripheral or central auditory system. We become "auditory-centric" and ignore the fact that most regions of the central auditory pathway receive inputs and send outputs to many nonauditory centers involved with emotion, memory, body position, vision, touch and likely many other regions. By integrating many different types of information, we are able to carry out complex activities such as turning our he...περισσότερα »

Enterococcus Growth on Eelgrass (Zostera marina); Implications for Water Quality

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Enterococci are fecal indicator bacteria used to monitor fecal pollution of recreational waters. When enterococci levels exceed health standards, fecal pollution is assumed as the cause. Enterococci growing on plants limit their usefulness as fecal indicator bacteria. Here we examined enterococcal growth on eelgrass in Mission Bay, CA where enterococci levels have exceeded water quality thresholds. 69 eelgrass samples were collected from six sites, shaken to remove enterococci attached to plant surfaces and the eluant filtered onto culture media. Isolates were then identified to s...περισσότερα »

Hospitals and GPs are offered incentives to reduce antibiotic prescribing

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
GPs and hospitals in England will be given incentives to reduce the number of antibiotics they prescribe, in an effort to tackle the growing problem of antibiotic resistance.NHS England announced… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QXlMfV via IFTTT

Rates of prophylactic mastectomy triple in decade, study shows

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
The rates of prophylactic mastectomy more than tripled from 2002 to 2012 in a US cohort of women with invasive breast cancer despite this option offering no significant survival benefit over breast… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1V5VoFJ via IFTTT

IJERPH, Vol. 13, Pages 313: Exploring Associations between Problematic Internet Use, Depressive Symptoms and Sleep Disturbance among Southern Chinese Adolescents

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
The primary aim of this study was to examine associations between problematic Internet use, depression and sleep disturbance, and explore whether there were differential effects of problematic Internet use and depression on sleep disturbance. A total of 1772 adolescents who participated in the Shantou Adolescent Mental Health Survey were recruited in 2012 in Shantou, China.… Continue reading IJERPH, Vol. 13, Pages 313: Exploring Associations between Problematic Internet Use, Depressive Symptoms and Sleep Disturbance among Southern Chinese Adolescents

Viruses, Vol. 8, Pages 79: Characterization of Intra-Type Variants of Oncogenic Human Papillomaviruses by Next-Generation Deep Sequencing of the E6/E7 Region

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Different human papillomavirus (HPV) types are characterized by differences in tissue tropism and ability to promote cell proliferation and transformation. In addition, clinical and experimental studies have shown that some genetic variants/lineages of high-risk HPV (HR-HPV) types are characterized by increased oncogenic activity and probability to induce cancer. In this study, we designed and validated… Continue reading Viruses, Vol. 8, Pages 79: Characterization of Intra-Type Variants of Oncogenic Human Papillomaviruses by Next-Generation Deep Sequencing of the E6/E7 Region

The complexity of daily life walking in older adult community-dwelling fallers and non-fallers

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Publication date: Available online 13 March 2016 Source:Journal of Biomechanics Author(s): Espen A.F. Ihlen, Aner Weiss, Alan Bourke, Jorunn L. Helbostad, Jeffrey M. Hausdorff Complexity of human physiology and physical behavior has been suggested to decrease with aging and disease and make older adults more susceptible to falls. The present study investigates complexity in daily… Continue reading The complexity of daily life walking in older adult community-dwelling fallers and non-fallers

Hitachi signs biopsy deal with MedCom

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Hitachi Medical Systems Europe has signed an agreement with MedCom to distribute… Read more on AuntMinnieEurope.com Related Reading: Hitachi Aloka debuts Arietta V70 with enhanced elastography functions Hitachi unveils new ultrasound system Fujifilm, Hitachi sign distribution deal Hitachi launches new version of Oasis at ECR Xograph forms alliance with Hitachi from #ORL-AlexandrosSfakianakis via simeraentaxei on… Continue reading Hitachi signs biopsy deal with MedCom

U.K. research could advance MRI lung scans

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
British researchers have developed a process using specially treated krypton… Read more on AuntMinnieEurope.com Related Reading: MRI lung perfusion looks set for broader clinical use from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QXekkW via IFTTT

ESTI reschedules meeting for Krakow in October

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
After canceling its annual meeting in Istanbul due to concerns over security,… Read more on AuntMinnieEurope.com Related Reading: Security concerns lead to cancellation of ESTI 2016 ESTI prepares for joint meeting in Spain ESTI: New 3D tool displays promise for rib evaluations ESTI prepares for annual meeting in Amsterdam from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader… Continue reading ESTI reschedules meeting for Krakow in October

Percutaneous cryoablation of hepatic tumors: Long-term experience of a large U.S. series

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Association of financial strain with symptom burden and quality of life for patients with lung or colorectal cancer

Journal of Clinical Oncologyfrom Gastroenterology via xlomafota13 on Inoreader http://ift.tt/1QRYFGQvia IFTTT

The genetics of drug efficacy: opportunities and challenges

Nature Reviews Genetics. doi:10.1038/nrg.2016.12 Authors: Matthew R. Nelson, Toby Johnson, Liling Warren, Arlene R. Hughes, Stephanie L. Chissoe, Chun-Fang Xu & Dawn M. Waterworthfrom Genetics via xlomafota13 on Inoreader http://ift.tt/1nIgPPIvia IFTTT

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