Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τετάρτη 9 Μαρτίου 2016

OtoRhinoLaryngology & Medicine,New Articles,March 9th,2016,a


Outcomes of an International Audiology Service-Learning Study-Abroad Program

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 4 δευτερόλεπτα
Outcomes of an International Audiology Service-Learning Study-Abroad Program: PurposeThe purpose of this study was to evaluate students' academic and civic learning, with particular interest in cultural competence, gained through participation in the Speech, Language, and Hearing Sciences in Zambia study-abroad program. MethodTwelve female students participated in the program. Quantitative data collected included pre- and postprogram administration of the Public Affairs Scale (Levesque-Bristol & Cornelius-White, 2012) to measure changes in participants' civic learning. Qualitat...περισσότερα »

Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Impedance Changes and Fibrous Tissue Growth after Cochlear Implantation Are Correlated and Can Be Reduced Using a Dexamethasone Eluting Electrode: Background The efficiency of cochlear implants (CIs) is affected by postoperative connective tissue growth around the electrode array. This tissue formation is thought to be the cause behind post-operative increases in impedance. Dexamethasone (DEX) eluting CIs may reduce fibrous tissue growth around the electrode array subsequently moderating elevations in impedance of the electrode contacts.Methods For this study, DEX was incorpora...περισσότερα »

Cross-Modal and Intra-Modal Characteristics of Visual Function and Speech Perception Performance in Postlingually Deafened, Cochlear Implant Users

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Cross-Modal and Intra-Modal Characteristics of Visual Function and Speech Perception Performance in Postlingually Deafened, Cochlear Implant Users: Evidence of visual-auditory cross-modal plasticity in deaf individuals has been widely reported. Superior visual abilities of deaf individuals have been shown to result in enhanced reactivity to visual events and/or enhanced peripheral spatial attention. The goal of this study was to investigate the association between visual-auditory cross-modal plasticity and speech perception in post-lingually deafened, adult cochlear implant (CI) use...περισσότερα »

Stereotactic LINAC-Radiosurgery for Glomus Jugulare Tumors

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Stereotactic LINAC-Radiosurgery for Glomus Jugulare Tumors: A Long-Term Follow-Up of 27 Patients: Background The optimal treatment of glomus jugulare tumors (GJTs) remains controversial. Due to the critical location, microsurgery still provides high treatment-related morbidity and a decreased quality of life. Thus, we performed stereotactical radiosurgery (SRS) for the treatment of GJTs and evaluated the long-term outcome.Methods Between 1991 and 2011, 32 patients with GJTs underwent SRS using a linear accelerator (LINAC) either as primary or salvage therapy. Twenty-seven patie...περισσότερα »

Dangerous practices with coal-burning stoves inside the home accounted for the majority of CO poisoning incidents. Community health centers should provide instruction to and supervision of residents on proper installation and use of home heating stoves as well as inspection of installation.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Risk Factors for Non-Occupational Carbon Monoxide Poisoning: Anshan Prefecture, Liaoning Province, China, 2011–2012: Background Carbon monoxide (CO) poisoning can be fatal but is preventable. From October 2010 to February 2011, Anshan Prefecture reported 57 cases of non-occupational CO poisoning in District A, with two deaths. We conducted an investigation to identify risk factors and recommend preventive measures.Methods We defined a possible case of non-occupational CO poisoning as onset of at least two of the following symptoms: fatigue, headache, dizziness, nausea, vomitin...περισσότερα »

Primary Hyperventilation in the Emergency Department: A First Overview

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Primary Hyperventilation in the Emergency Department: A First Overview: Background Primary hyperventilation is defined as a state of alveolar ventilation in excess of metabolic requirements, leading to decreased arterial partial pressure of carbon dioxide. The primary aim of this study was to characterise patients diagnosed with primary hyperventilation in the ED.Methods Our retrospective cohort study comprised adult (≥16 years) patients admitted to our ED between 1 January 2006 and 31 December 2012 with the primary diagnosis of primary (=psychogenic) hyperventilation.Result...περισσότερα »

Risk Factors for Prolonged Treatment of Whiplash-Associated Disorders

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Risk Factors for Prolonged Treatment of Whiplash-Associated Disorders: Objectives Whiplash-associated disorders (WAD) are the most common injuries that are associated with car collisions in Japan and many Western countries. However, there is no clear evidence regarding the potential risk factors for poor recovery from WAD. Therefore, we used an online survey of the Japanese population to examine the association between potential risk factors and the persistence of symptoms in individuals with WAD.Materials and Methods An online survey was completed by 127,956 participants, inclu...περισσότερα »

Patterns of Adverse Drug Reactions in Different Age Groups

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Patterns of Adverse Drug Reactions in Different Age Groups: Analysis of Spontaneous Reports by Community Pharmacists: Purpose To evaluate the clinical manifestations and causative drugs associated with adverse drug reactions (ADRs) spontaneously reported by community pharmacists and to compare the ADRs by age.Methods ADRs reported to the Regional Pharmacovigilance Center of the Korean Pharmaceutical Association by community pharmacists from January 2013 to June 2014 were included. Causality was assessed using the WHO-Uppsala Monitoring Centre system. The patient population was c...περισσότερα »

Mal de debarquement syndrome (MdDS) is a disorder of chronic self-motion perception that occurs though entrainment to rhythmic background motion, such as from sea voyage, and involves the perception of low-frequency rocking that can last for months or years.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Voxel Based Morphometry Alterations in Mal de Debarquement Syndrome: Background Mal de debarquement syndrome (MdDS) is a disorder of chronic self-motion perception that occurs though entrainment to rhythmic background motion, such as from sea voyage, and involves the perception of low-frequency rocking that can last for months or years. The neural basis of this persistent sensory perception abnormality is not well understood.Methods We investigated grey matter volume differences underlying persistent MdDS by performing voxel-based morphometry on whole brain and pre-specified ROI...περισσότερα »

Human Vection Perception Using Inertial Nulling and Certainty Estimation: The Effect of Migraine History

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Human Vection Perception Using Inertial Nulling and Certainty Estimation: The Effect of Migraine History: Vection is an illusory perception of self-motion that can occur when visual motion fills the majority of the visual field. This study examines the effect of the duration of visual field movement (VFM) on the perceived strength of self-motion using an inertial nulling (IN) and a magnitude estimation technique based on the certainty that motion occurred (certainty estimation, CE). These techniques were then used to investigate the association between migraine diagnosis and the str...περισσότερα »

Prevalence and Predictors of Somatic Symptoms among Child and Adolescents with Probable Posttraumatic Stress Disorder

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
A Cross-Sectional Study Conducted in 21 Primary and Secondary Schools after an Earthquake: Purpose To explore the prevalence rates and predictors of somatic symptoms among child and adolescent survivors with probable posttraumatic stress disorder (PTSD) after an earthquake.Methods A total of 3053 students from 21 primary and secondary schools in Baoxing County were administered the Patient Health Questionnaire-13 (PHQ-13), a short version of PHQ-15 without the two items about sexuality and menstruation, the Children's Revised Impact of Event Scale (CRIES), and the self-made Ea...περισσότερα »

Period Prevalence of Dizziness and Vertigo in Adolescents

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Period Prevalence of Dizziness and Vertigo in Adolescents: Objectives To assess the period prevalence and severity of dizziness and vertigo in adolescents.Methods In 1661 students in 8th-10th grade in twelve grammar schools in Munich, Germany information on vertigo/dizziness was assessed by a questionnaire in the class room setting. Three month prevalence of dizziness/vertigo was estimated; symptoms were categorized as orthostatic dizziness, spinning vertigo, swaying vertigo or unspecified dizziness. Duration of symptoms and impact on daily life activities were assessed.Result...περισσότερα »

Persistent Postural-Perceptual Dizziness: A Matter of Higher, Central Dysfunction?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Persistent Postural-Perceptual Dizziness: A Matter of Higher, Central Dysfunction?: Objective Persistent postural-perceptual dizziness (PPPD) is the most common vestibular disorder in the age group between 30 and 50 years. It is considered to be based on a multisensory maladjustment involving alterations of sensory response pattern including vestibular, visual and motion stimuli. Previous data supported a link between vestibular and pain mechanism. The aim of the study was to investigate whether other sensory inputs such as pain stimuli might be altered in terms of a more widesprea...περισσότερα »

Neurosensory Symptom Complexes after Acute Mild Traumatic Brain Injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Neurosensory Symptom Complexes after Acute Mild Traumatic Brain Injury: Mild Traumatic Brain Injury (mTBI) is a prominent public health issue. To date, subjective symptom complaints primarily dictate diagnostic and treatment approaches. As such, the description and qualification of these symptoms in the mTBI patient population is of great value. This manuscript describes the symptoms of mTBI patients as compared to controls in a larger study designed to examine the use of vestibular testing to diagnose mTBI. Five symptom clusters were identified: Post-Traumatic Headache/Migraine, Na...περισσότερα »

Oculomotor Deficits after Chemotherapy in Childhood

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Oculomotor Deficits after Chemotherapy in Childhood: Advances in the diagnosis and treatment of pediatric malignancies have substantially increased the number of childhood cancer survivors. However, reports suggest that some of the chemotherapy agents used for treatment can cross the blood brain barrier which may lead to a host of neurological symptoms including oculomotor dysfunction. Whether chemotherapy at young age causes oculomotor dysfunction later in life is unknown. Oculomotor performance was assessed with traditional and novel methods in 23 adults (mean age 25.3 years, trea...περισσότερα »

Arterial Spin Labeling Perfusion Study in the Patients with Subacute Mild Traumatic Brain Injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Arterial Spin Labeling Perfusion Study in the Patients with Subacute Mild Traumatic Brain Injury: Background This study uses a MRI technique, three-dimension pulse continuous arterial spin labeling (3D-PCASL), to measure the patient’s cerebral blood flow (CBF) at the subacute stage of mild traumatic brain injury (MTBI) in order to analyze the relationship between cerebral blood flow and neurocognitive deficits.Objective To provide the relationship between cortical CBF and neuropsychological dysfunction for the subacute MTBI patients.Methods After MTBI, perfusion MR imaging...περισσότερα »

Tinnitus Self-Efficacy and Other Tinnitus Self-Report Variables in Patients With and Without Post-Traumatic Stress Disorder.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Tinnitus Self-Efficacy and Other Tinnitus Self-Report Variables in Patients With and Without Post-Traumatic Stress Disorder.: Objective: Individuals with tinnitus and co-occurring psychological conditions typically rate their tinnitus as more disturbing than individuals without such comorbidities. Little is known about how tinnitus self-efficacy, or the confidence that individuals have in their abilities to successfully manage the effects of tinnitus, is influenced by mental or psychological health (PH) status. The purpose of this study was to examine the influence of psychological ...περισσότερα »

A Wide-diameter Bone-anchored Hearing Implant and a Surgical Technique With Tissue Preservation.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Clinical Outcome of a Wide-diameter Bone-anchored Hearing Implant and a Surgical Technique With Tissue Preservation.: Objective: To investigate the clinical outcome of a surgical technique with tissue preservation for a wide bone-anchored hearing implant concerning postoperative complications, skin reactions, implant loss, and implant stability.Study Design: Consecutive, prospective case series.Setting: Tertiary referral center.Patients: Twenty-four adult patients with normal skin quality were enrolled. Intervention(s): Implantation of bone-anchored implant was performed using a...περισσότερα »

Psychiatric Disorders in Intractable Peripheral Vertiginous Patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Quantitative Analysis of Psychiatric Disorders in Intractable Peripheral Vertiginous Patients: A Prospective Study.: Objective: To investigate the correlation between psychological disorder and vestibular dysfunction in patients suffering from intractable peripheral vertigo.Study Design: Prospective study.Setting: In-patients in a university hospital.Methods: Prospective design of 26 intractable peripheral vertiginous patients with peripheral vestibular dysfunction and 20 controls recruited from the EENT hospital. Hospital Anxiety and Depression scale, Self-rating Anxiety scale,...περισσότερα »

Endoscopic Keyhole Middle Fossa Craniotomy Approach to the Superior Semicircular Canal.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 5 δευτερόλεπτα
Cadaveric Study of an Endoscopic Keyhole Middle Fossa Craniotomy Approach to the Superior Semicircular Canal.: Objective: Demonstrate that an endoscopic keyhole approach to the middle cranial fossa is technically feasible for repair of semicircular canal dehiscence.Study Design: Cadaveric technical feasibility/methods development study.Setting: Tertiary care military medical center.Patients: Three fresh cadaveric heads (six sides). Intervention(s): Endoscopic minimally invasive approach to the middle cranial fossa using the Medtronic Fusion Guidance system.Main Outcome Measure(...περισσότερα »

Disrupted Functional Brain Connectome in Unilateral Sudden Sensorineural Hearing Loss

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
Disrupted Functional Brain Connectome in Unilateral Sudden Sensorineural Hearing Lossvia Hearing ResearchPublication date: Available online 9 March 2016*Source:*Hearing ResearchAuthor(s): Haibo Xu, Wenliang Fan, Xueyan Zhao, Jing Li, Wenjuan Zhang, Ping Lei, Yuan Liu, Haha Wang, Huamao Cheng, Hong ShiSudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and verti...περισσότερα »

Impulse noise injury prediction based on the cochlear energy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 6 δευτερόλεπτα
Impulse noise injury prediction based on the cochlear energyvia Hearing ResearchPublication date: Available online 9 March 2016*Source:*Hearing ResearchAuthor(s): Brissi Zagadou, Philemon Chan, Kevin Ho, David ShelleyThe current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk correlate (DRC). The m...περισσότερα »

Injury grade is a predictor of aortic-related death among patients with blunt thoracic aortic injury

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Journal of Vascular Surgeryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SySdWk

Cerebral oximetry and capnography in excessive hyperventilated pediatric increase ICP patients: case series demonstrating the physiologic premise, excessive hyperventilation leads to decreased regional cerebral blood flow and oxygenation

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The American Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcovD

Efficacy of simulation application SimMon for emergency response training

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The American Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SySbxN

Knowledge about Hepatitis C Virus Infection and Acceptability of Testing in the 1945–1965 Birth Cohort (Baby Boomers) Presenting to a Large Urban Emergency Department: A Pilot Study

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcofa

Orbital compartment syndrome due to acute hemorrhage within an orbital lymphatic malformation: emergency treatment with percutaneous sclerotherapy

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Journal of Vascular and Interventional Radiology from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SySdFK

A quick and easy delirium assessment for non-physician research personnel

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The American Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SySdpo

Postoperative negative pressure therapy significantly reduces flap complications in distally based peroneus brevis flaps: Experiences from 74 cases

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Injuryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcmUH

The impact of transfer on pediatric trauma outcomes

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Journal of Pediatric Surgeryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SySb0D

Prevalence of marijuana use disorders in the United States between 2001-2001 and 2012-2013

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcnIe

Outcomes of basic versus advanced life support for out-of-hospital medical emergencies

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SySaKh

Improved identification of sternal injuries with multi-detector computed tomography (MDCT): sagittal reconstructions

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Clinical Imagingfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcmDZ

Comparison of the VivaSight™ single lumen endotracheal tube and the Macintosh laryngoscope for emergency intubation by experienced paramedics in a standardized airway manikin with restricted access. A randomized, crossover trial

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The American Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SyScSg

Progesterone for traumatic brain injury: a meta-narrative review of randomized controlled trials

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
World Neurosurgeryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcmDV

Analgesic adherence in recently discharged trauma patients: An integrative literature review

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Pain Management Nursingfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SyScBM

The impact of a preauthorization policy on the after-hours utilization of emergency department computed tomography imaging

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Academic Radiologyfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcnrD

Early trends among seven recommendations from the choosing wisely campaign

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SyS9Gg

Prevalence of chronic compartment syndrome of the legs: Implications for clinical diagnostic criteria and therapy

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Scandinavian Journal of Painfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcmns

Post-trauma mortality increase at age 60: a cut-off for defining elderly?

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
The American Journal of Surgeryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1SySad8

Impact of an emergency department observation unit management algorithm for atrial fibrillation

Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Journal of the American Heart Associationfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1QLcm74

Tough to Swallow: Esophageal Food Impaction from Esophageal Amyloidosis

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 11 δευτερόλεπτα
from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/1pfUvytvia IFTTT

Patterns of lymphatic spread and the management of eyelid carcinomas

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Patterns of lymphatic spread and the management of eyelid carcinomasvia Auris Nasus LarynxPublication date: Available online 7 March 2016*Source:*Auris Nasus LarynxAuthor(s): Kazuki Hashimoto, Ryuji Yasumatsu, Satoshi Toh, Hideki Shiratsuchi, Takamasa Yoshida, Kazuo Nishiyama, Hiroshi Yoshikawa, Torahiko Nakashima, Takashi NakagawaObjectiveEyelid carcinomas are rare, and the management strategy of regional lymph node metastasis linked to eyelid carcinomas has not been standardized to date. The aim of the present study was to analyze the patterns of regional metastasis and to asses...περισσότερα »

Tracheoesophageal fistula length decreases over time

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Tracheoesophageal fistula length decreases over time: AbstractThe objectives of this study were to demonstrate that the length of the tracheoesophageal voice prosthesis changes over time and to determine whether the prosthesis length over time increased, decreased, or showed no predictable change in size. A retrospective chart review was performed at a tertiary care referral center. Patients who underwent either primary or secondary tracheoesophageal puncture between January 2006 and August 2014 were evaluated. Patients were excluded if the tracheoesophageal prosthesis size was not...περισσότερα »

Extracorporeal Perfusion of Microvascular Free Flaps

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
Extracorporeal Perfusion of Microvascular Free Flaps: *Conditions*: Perfusion; Complication of Perfusion*Intervention*: Procedure: Perfusion of flaps by a special bypass system*Sponsor*: Technische Universität MünchenThe perfusion of microvascular free flaps is inevitable for completion of reconstruction in the head and neck area. In some patients microvascular anastomosis is impossible because of arteriosclerotic changes, different oncological interventions, and consecutive vessel depletion at the neck. The aim of the project is to establish an innovative system for e...περισσότερα »

The Oral Cavity as a Source of Febrile Neutropenia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 13 δευτερόλεπτα
The Oral Cavity as a Source of Febrile Neutropenia: *Conditions*: Febrile Neutropenia; Solid Tumors; Dental Infection; Oral Infection*Intervention*: *Sponsor*: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Febrile neutropenia (FN) is a clinically important adverse effect of myelosuppressive chemotherapy. If patients present with FN, attention is focussed on well-recognized sites of origin of infection: the airways, urinary tracts, and skin. However, infections can be only documented clinically in about two-third of febrile episodes, whereas a cau...περισσότερα »

Long noncoding RNAs related to the odontogenic potential of dental mesenchymal cells in mice

Alexandros G. SfakianakisστοΚοσμητική ΟδοντοΙατρική και ΓναθοΧειρουργικήΠριν από 14 δευτερόλεπτα
Publication date: Available online 8 March 2016 *Source:*Archives of Oral BiologyAuthor(s): Yunfei Zheng, Lingfei Jia ObjectivesThe purpose of this study is to identify the lncRNAs that are associated with the odontogenic potential in mouse dental mesenchymal cells.DesignThe odontogenic potential of dental mesenchymal cells was found to be lost in the course of in vitro culture, so the lncRNA profiles were subsequently compared between freshly-isolated and cultured dental mesenchymal cells using RNA-sequencing. A co-expression analysis of differentially expressed lncRNAs and coding...περισσότερα »

Eye lens dosimetry in anesthesiology: a prospective study

Alexandros G. SfakianakisστοThyroid Disorders by Alexandros G.SfakianakisΠριν από 15 δευτερόλεπτα
Abstract The eye lens is one of the most sensitive organs for radiation injury and exposure might lead to radiation induced cataract. Eye lens dosimetry in anesthesiology has been published in few clinical trials and an active debate about the causality of radiation induced cataract is still ongoing. Recently, the International Commission on Radiological Protection (ICRP) recommended a reduction in the annual dose limit for occupational exposure for the lens of the eye from 150 to 20 mSv, averaged over a period of 5 years, with the dose in a single year not exceeding 50 mSv. This ...περισσότερα »

Phase 2 Trial of Lenvatinib (E7080) in Subjects With Iodine-131 Refractory Differentiated Thyroid Cancer to Evaluate Whether an Oral Starting Dose of 20 mg or 14 mg Daily Will Provide Comparable Efficacy to a 24 mg Starting Dose, But Have a Better Safety Profile

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
Phase 2 Trial of Lenvatinib (E7080) in Subjects With Iodine-131 Refractory Differentiated Thyroid Cancer to Evaluate Whether an Oral Starting Dose of 20 mg or 14 mg Daily Will Provide Comparable Efficacy to a 24 mg Starting Dose, But Have a Better Safety Profile: *Condition*: Thyroid Cancer*Interventions*: Drug: Lenvatinib; Drug: Lenvatinib matching placebo *Sponsor*: Eisai Inc.This is a multicenter, randomized, double-blind study being conducted as a postmarketing requirement to the US Food and Drug Administration (FDA) to evaluate whether there is a lower starting dosa...περισσότερα »

Combination Therapies Using an Intratympanic Polymer Gel Delivery System

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 15 δευτερόλεπτα
in the Guinea Pig Animal Model: A Safety Studyvia International Journal of Pediatric OtorhinolaryngologyPublication date: Available online 7 March 2016*Source:*International Journal of Pediatric OtorhinolaryngologyAuthor(s): Douglas Sidell, Jonette A. Ward, Angad Pordal, Carson Quimby, Michel Nassar, Daniel I. ChooObjectivesHigh dose antivirals have been shown to cause hearing loss when applied via the intratympanic route. The aim of this study was to determine if a combination therapy using dexamethasone (DXA) with either Cidofovir (CDV) or Ganciclovir (GCV), in solution or in PL...περισσότερα »

Track Recurrence After Robotic Transaxillary Thyroidectomy: A Case Report Highlighting the Importance of Controlled Surgical Indications and Addressing Unprecedented Complications

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Track Recurrence After Robotic Transaxillary Thyroidectomy: A Case Report Highlighting the Importance of Controlled Surgical Indications and Addressing Unprecedented Complications: Author informationSohail Bakkar, Gianluca Frustaci, Piermarco Papini, Lorenzo Fregoli, Valeria Matteucci, Gabriele Materazzi, and Paolo MiccoliDivision of Surgery, Department of Surgical Pathology, University Hospital of Pisa, Pisa, Italy.Address correspondence to: *Sohail Bakkar, MD, MS**30 E, 2nd Piano, Endocrino Chirurgia**Division of Surgery**Department of Surgical Pathology**University Hospital ...περισσότερα »

Human Papilloma virus in Juvenile Nasopharyngeal Angiofibroma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
: Possible Recent trendvia American Journal of OtolaryngologyPublication date: Available online 8 March 2016*Source:*American Journal of OtolaryngologyAuthor(s): Mishra Anupam, Sachadeva Monica, Jain Ankita, Shukla Mishra Nimisha, Pandey AmitaBackgroundJuvenile nasopharyngeal angiofibroma (JNA) has witnessed a four-fold increase in the incidence at our facility in the current decade as compared to the 1980s. With high global incidence of human pappilloma virus (HPV) related oropharyngeal cancer in India, we hypothesize its implication in JNA as it has not yet been reported.Methods...περισσότερα »

Magnetic Resonance Imaging for Diagnosis of Mandibular Involvement from Head and Neck Cancers: A Systematic Review and Meta-Analysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Magnetic Resonance Imaging for Diagnosis of Mandibular Involvement from Head and Neck Cancers: A Systematic Review and Meta-Analysis: Background Diagnosis of mandibular involvement caused by head and neck cancers is critical for treatment. We performed a meta-analysis to determine the diagnostic efficacy of MR for distinguishing mandibular involvement caused by head and neck cancers.Methods Thirteen databases were searched electronically and hand-searching was also done. Two reviewers conducted study inclusion, data extractions, and quality assessment of the studies independentl...περισσότερα »

Non-Steroidal Anti-Inflammatory Drugs Use Is Associated with Reduced Risk of Inflammation-Associated Cancers: NIH-AARP Study

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Non-Steroidal Anti-Inflammatory Drugs Use Is Associated with Reduced Risk of Inflammation-Associated Cancers: NIH-AARP Study: Background Chronic inflammation has been linked to cancers, and use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with reduced risk of several cancers. To further refine the magnitude of NSAID-related associations, in particular for cancers related to inflammation, such as alcohol-, infection-, obesity-, and smoking-related cancers, as well as for less common cancers, we evaluated the use of NSAIDs and cancer risk in a very large coho...περισσότερα »

Secondary Primary Malignancy Risk among Patients with Esophageal Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Secondary Primary Malignancy Risk among Patients with Esophageal Cancer in Taiwan: A Nationwide Population-Based Study: Background To evaluate the risk and sites of metachronous secondary primary malignancies (SPMs) among patients with esophageal cancer.Methods Newly diagnosed esophageal cancer patients between 1997 and 2011 were recruited. To avoid surveillance bias, SPMs that developed within one year were excluded. Standardized incidence ratios (SIRs) of metachronous SPMs in these patients were calculated by comparing to the cancer incidence in the general population. Risk fa...περισσότερα »

Adjuvant Chemotherapy with S-1 after Curative Treatment in Patients with Squamous-Cell Carcinoma of the Head and Neck (ACTS-HNC)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Randomized Phase III Trial of Adjuvant Chemotherapy with S-1 after Curative Treatment in Patients with Squamous-Cell Carcinoma of the Head and Neck (ACTS-HNC): Background We conducted a phase III study to evaluate S-1 as compared with UFT as control in patients after curative therapy for stage III, IVA, or IVB squamous-cell carcinoma of the head and neck (SCCHN). Patients and Methods Patients were randomly assigned to the UFT group (300 or 400 mg day-1 for 1 year) or the S-1 group (80, 100, or 120 mg day-1 for 1 year). The primary end point was disease-free survival (DFS). Second...περισσότερα »

Alcohol and Tobacco Consumption in Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Different Levels in Alcohol and Tobacco Consumption in Head and Neck Cancer Patients from 1957 to 2013: Objective To provide a precise quantification of the association between alcohol and tobacco consumption trends in head and neck cancer patients over the past 45 years. Methods We combined findings from all studies published until March 2014 and evaluated the association between different levels in alcohol and tobacco consumption and head and neck cancers through a meta-analytic approach.Results We included 28 studies involving 13830 patients with head and neck cancer. In p...περισσότερα »

EPHX1 Polymorphisms and the Risk of Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Systematic Review and Meta-Analysis of the Relationship between EPHX1 Polymorphisms and the Risk of Head and Neck Cancer: Aim To evaluate the association between the *EPHX1 Tyr113His* and *His139Arg* polymorphisms in the *EPHX1* gene and the risk of head and neck cancer.Materials and Methods Studies on the association of *EPHX1 Tyr113His* and *His139Arg* polymorphisms with HNC performed up until June 1st, 2014, were identified using a predefined search strategy. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of these associations....περισσότερα »

Age and Gender Variations in Cancer Diagnostic Intervals in 15 Cancers

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Age and Gender Variations in Cancer Diagnostic Intervals in 15 Cancers: Analysis of Data from the UK Clinical Practice Research Datalink: Background Time from symptomatic presentation to cancer diagnosis (diagnostic interval) is an important, and modifiable, part of the patient’s cancer pathway, and can be affected by various factors such as age, gender and type of presenting symptoms. The aim of this study was to quantify the relationships of diagnostic interval with these variables in 15 cancers diagnosed between 2007 and 2010 using routinely collected data from the Clinical P...περισσότερα »

Metachronous Second Primary Malignancies after Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Metachronous Second Primary Malignancies after Head and Neck Cancer in a Korean Cohort (1993-2010): Second primary malignancy (SPM) is the major long-term cause of patient mortality with head and neck squamous cell carcinoma (HNSCC). As the incidence of high-risk human papillomavirus (HPV)-related HNSCC is increasing globally, we analyzed the patterns of SPM occurrence, the effect of the index tumor site along with attributes to HPV, and the effect of SPM on survival in South Korean patients with head and neck cancer (HNC). Data were retrieved from the Korea Central Cancer Registry,...περισσότερα »

The Impact of Iterative Reconstruction on Computed Tomography Radiation Dosimetry: Evaluation in a Routine Clinical Setting

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
The Impact of Iterative Reconstruction on Computed Tomography Radiation Dosimetry: Evaluation in a Routine Clinical Setting: Purpose To evaluate the effect of introduction of iterative reconstruction as a mandated software upgrade on radiation dosimetry in routine clinical practice over a range of computed tomography examinations.Methods Random samples of scanning data were extracted from a centralised Picture Archiving Communication System pertaining to 10 commonly performed computed tomography examination types undertaken at two hospitals in Western Australia, before and after...περισσότερα »

Tumor-Associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Tumor-Associated Endothelial Cells Promote Tumor Metastasis by Chaperoning Circulating Tumor Cells and Protecting Them from Anoikis: Tumor metastasis is a highly inefficient biological process as millions of tumor cells are released in circulation each day and only a few of them are able to successfully form distal metastatic nodules. This could be due to the fact that most of the epithelial origin cancer cells are anchorage-dependent and undergo rapid anoikis in harsh circulating conditions. A number of studies have shown that in addition to tumor cells, activated endothelial cells ...περισσότερα »

Cisplatin-Associated Acute Kidney Injury

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Understanding the Risk Factors and Long-Term Consequences of Cisplatin-Associated Acute Kidney Injury: An Observational Cohort Study: Acute kidney injury (AKI) is a well-known complication of cisplatin-based chemotherapy; however, its impact on long-term patient survival is unclear. We sought to determine the incidence and risk factors for development of cisplatin-associated AKI and its impact on long-term renal function and patient survival. We identified 233 patients who received 629 cycles of high-dose cisplatin (99±9mg/m2) for treatment of head and neck cancer between 2005 and ...περισσότερα »

Cold Atmospheric Plasma for Squamous Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Cold Atmospheric Plasma: A Promising Complementary Therapy for Squamous Head and Neck Cancer: Head and neck squamous cell cancer (HNSCC) is the 7th most common cancer worldwide. Despite the development of new therapeutic agents such as monoclonal antibodies, prognosis did not change for the last decades. Cold atmospheric plasma (CAP) presents the most promising new technology in cancer treatment. In this study the efficacy of a surface micro discharging (SMD) plasma device against two head and neck cancer cell lines was proved. Effects on the cell viability, DNA fragmentation and ap...περισσότερα »

Tumor Necrosis Factor Inhibition and Head and Neck Cancer Recurrence and Death in Rheumatoid Arthritis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 16 δευτερόλεπτα
Tumor Necrosis Factor Inhibition and Head and Neck Cancer Recurrence and Death in Rheumatoid Arthritis: The objective of this retrospective cohort study was to determine the effect of tumor necrosis factor inhibitor (TNFi) therapy on the risk of head and neck cancer (HNC) recurrence or HNC-attributable death in patients with rheumatoid arthritis (RA). RA patients with HNC were assembled from the US national Veterans’ Affairs (VA) administrative databases, and diagnoses confirmed and data collected by electronic medical record review. The cohort was divided into those treated with ...περισσότερα »

Long noncoding RNAs related to the odontogenic potential of dental mesenchymal cells in mice

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 17 δευτερόλεπτα
Publication date: Available online 8 March 2016 *Source:*Archives of Oral BiologyAuthor(s): Yunfei Zheng, Lingfei Jia ObjectivesThe purpose of this study is to identify the lncRNAs that are associated with the odontogenic potential in mouse dental mesenchymal cells.DesignThe odontogenic potential of dental mesenchymal cells was found to be lost in the course of in vitro culture, so the lncRNA profiles were subsequently compared between freshly-isolated and cultured dental mesenchymal cells using RNA-sequencing. A co-expression analysis of differentially expressed lncRNAs and coding...περισσότερα »

Impulse noise injury prediction based on the cochlear energy

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 17 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Brissi Zagadou, Philemon Chan, Kevin Ho, David ShelleyThe current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk correlate (DRC). The model parameters have been corrected using the latest literature data. The anoma...περισσότερα »

Disrupted Functional Brain Connectome in Unilateral Sudden Sensorineural Hearing Loss

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 17 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Haibo Xu, Wenliang Fan, Xueyan Zhao, Jing Li, Wenjuan Zhang, Ping Lei, Yuan Liu, Haha Wang, Huamao Cheng, Hong ShiSudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral sudden sensorineural hearing loss is still unknown, and the alteration...περισσότερα »

ANO1 and FADD as Prognostic Markers of Head and Neck Cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Meta-Analyses of Microarray Datasets Identifies ANO1 and FADD as Prognostic Markers of Head and Neck Cancer: The head and neck squamous cell carcinoma (HNSCC) transcriptome has been profiled extensively, nevertheless, identifying biomarkers that are clinically relevant and thereby with translational benefit, has been a major challenge. The objective of this study was to use a meta-analysis based approach to catalog candidate biomarkers with high potential for clinical application in HNSCC. Data from publically available microarray series (N = 20) profiled using Agilent (4X44K G4112F...περισσότερα »

Socioeconomic and Other Demographic Disparities Predicting Survival among Head and Neck Cancer Patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Socioeconomic and Other Demographic Disparities Predicting Survival among Head and Neck Cancer Patients: Background The Institute of Medicine (IOM) report, “Unequal Treatment,â€� which defines disparities as racially based, indicates that disparities in cancer diagnosis and treatment are less clear. While a number of studies have acknowledged cancer disparities, they have limitations of retrospective nature, small sample sizes, inability to control for covariates, and measurement errors.Objective The purpose of this study was to examine disparities as predictors of survival a...περισσότερα »

Association of VDR and CYP2R1 Polymorphisms with Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Association of VDR and CYP2R1 Polymorphisms with Mite-Sensitized Persistent Allergic Rhinitis in a Chinese Population: As recent studies have described an association between vitamin D and allergic rhinitis, we hypothesized that vitamin D pathway-related genes may be candidate genes for susceptibility to allergic rhinitis. Thus, we sought to evaluate whether polymorphisms in the vitamin D receptor (*VDR*) and *CYP2R1* genes are associated with mite-sensitized persistent allergic rhinitis (PER) in a Han Chinese population. A hospital-based case-control study consisting of 519 patient...περισσότερα »

Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine: AbstractVestibular migraine (VM), defined as vestibular symptoms caused by migraine mechanisms, is very common but poorly understood. Because dizziness is often provoked in VM patients when the semicircular canals and otolith organs are stimulated concurrently (e.g., tilting the head relative to gravity), we measured tilt perception and eye movements in patients with VM and in migraine and normal control subjects during fixed-radius centrifugation, a paradigm that simultaneously modulates afferent ...περισσότερα »

GMP-grade α-TEA lysine salt: a 28-Day oral toxicity and toxicokinetic study with a 28-Day recovery period in Beagle dogs

Alpha-tocopheryloxyacetic acid (α-TEA) is a semi-synthetic derivative of naturally occurring vitamin E (alpha-tocopherol) that can be delivered via an oral route. Preclinical in vitro and in vivo data demonstr… (Source: BMC Cancer) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QLqNrO via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Human papillomavirus vaccine series completion: Qualitative information from providers within an integrated healthcare organization.

CONCLUSION: Interventions to improve HPV vaccination completion rates should address both individual- and system-level factors. Improving communication skills, encouraging a supportive medical culture, and addressing resource issues is likely to improve vaccine adherence. PMID: 26947497 [PubMed – as supplied by publisher] (Source: Vaccine) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TsqJ5L via IFTTT Medicine by Alexandros […]

Rabies transmission risks during peripartum – Two cases and a review of the literature.

We report two cases of probable rabies in near-term/at-term pregnant women in sub-Saharan Africa and Asia. One baby was delivered by caesarean section and the other one vaginally. Both received post-exposure prophylaxis (PEP), including RIG and vaccine and both are alive and healthy, at 9 and 24 months, respectively. We found 14 other published cases […]

Quality vaccines for all people: Report of the annual general meeting of the developing countries vaccine manufacturers network, 05-07th October 2015, Bangkok, Thailand.

Authors: Pagliusi S, Ting CC, Khomvilai S, DCVMN Executive, Organising Committee Group, DCVMN Executive Organising Committee Group Abstract The Developing Countries Vaccine Manufacturers Network (DCVMN) assembled high-profile leaders from global health organisations and vaccine manufactures for its 16th Annual General Meeting to work towards a common goal: providing quality vaccines for all people. Vaccines contribute […]

Safety of classical swine fever virus vaccine strain LOM in pregnant sows and their offspring.

Authors: Lim SI, Song JY, Kim J, Hyun BH, Kim HY, Cho IS, Kim BH, Woo GH, Lee JB, An DJ Abstract The present study aimed to evaluate the safety of the classical swine fever virus (CSFV) vaccine strain LOM in pregnant sows. Pregnant sows with free CSFV antibody were inoculated with a commercial LOM […]

Do selective immunisation against tuberculosis and hepatitis B reach the targeted populations? A nationwide register-based study evaluating the recommendations in the Norwegian Childhood Immunisation Programme.

CONCLUSIONS: Children targeted by selective vaccination had lower coverage of the target vaccines than of vaccines in the universal programme, indicating that selective vaccination is challenging. Improved routines for identifying eligible children and delivering the target vaccines are needed. Universal vaccination of all children with these vaccines could be considered. PMID: 26947498 [PubMed – as […]

Six Ways to Reduce Your Risk of Colon Cancer

Diet, weight and physical activity play a significant role, expert says (Source: The Doctors Lounge – Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QLqIV4 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Wonders & Worries: evaluation of a child centered psychosocial intervention for families who have a parent/primary caregiver with cancer

ConclusionsThe results reported here suggest that this child centered psychosocial intervention promoted positive adaptation by actively supporting families and children while a parent/primary caregiver coped with a cancer diagnosis. Future research is planned utilizing a randomized controlled study design to formally evaluate the effectiveness and preventative impact of this manualized six‐week curriculum. Copyright © 2016 […]

Impact of high self‐perceived burden to others with preferences for end‐of‐life care and its determinants for terminally ill cancer patients: a prospective cohort study

ConclusionsHigh SPB was prevalent among terminally ill cancer patients but independent of preferences for EOL care. Cancer patients’ SPB may be lessened by adequate symptom relief to facilitate functional independence. These strategies to ease SPB may improve the quality of death and dying. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Psycho-Oncology) from #Medicine-SfakianakisAlexandros […]

A randomized pilot trial of a videoconference couples communication intervention for advanced GI cancer

ConclusionsA couples‐based communication intervention delivered via videoconference is feasible and acceptable in the context of advanced cancer. Preliminary findings suggest that the intervention shows promise in contributing to enhanced relationship functioning. Copyright © 2016 John Wiley & Sons, Ltd. (Source: Psycho-Oncology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TsqDes via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 […]

A comparative study of target ionization between hydrogen and hydrogenic ion by positronium impact

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 37 δευτερόλεπτα
Abstract A comparative study is made between the collision cross sections of target ionization process of hydrogen and some hydrogenic ions by positronium impact. Calculations are performed in the framework of Coulomb distorted eikonal approximation. Interesting qualitative features are noted in both the scattered positronium and the ejected electron distributions.from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/1R776A2via IFTTT

Moderate and Vigorous Intensity Exercise During Pregnancy and Gestational Weight Gain in Women with Gestational Diabetes

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 37 δευτερόλεπτα
Abstract *Objectives* To estimate the associations of moderate and vigorous intensity exercise during pregnancy with the rate of gestational weight gain (GWG) from gestational diabetes (GDM) diagnosis to delivery, overall and stratified by prepregnancy overweight/obesity. *Methods* Prospective cohort study with physical activity reported shortly after the GDM diagnosis and prepregnancy weight and post-diagnosis GWG obtained from electronic health records (n = 1055). Multinomial logistic regression models in the full cohort and stratified by prepregnancy overweight/obesity estimate...περισσότερα »

Intimate Partner Violence Associated with Postpartum Depression, Regardless of Socioeconomic Status

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 37 δευτερόλεπτα
Abstract *Objective* This study examined whether socioeconomic status moderated the association between intimate partner violence (IPV) and postpartum depression among a community-based sample of women. Defining the role of poverty in the risk of postpartum depression for IPV victims enables prioritization of health promotion efforts to maximize the effectiveness of existing maternal-infant resources. *Methods* This cross-sectional telephone-survey study interviewed 301 postpartum women 2 months after delivery, screening them for IPV and depression [using Edinburgh Postnatal Depre...περισσότερα »

The Impact of Balanced Counseling on Contraceptive Method Choice and Determinants of Long Acting and Reversible Contraceptive Continuation in Nepal

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 37 δευτερόλεπτα
Abstract *Introduction* Long-acting reversible contraceptives (LARCs) reduce rates of unintended pregnancies and repeat abortion. Uptake and continuation rates of LARCs are very low in Nepal, despite free provision from most health facilities. We sought to establish the effectiveness of a new approach to LARC promotion in Nepal. *Methods* We examined change in contraceptive method mix in Nepal using service data resulting from introduction of a balanced counseling (BC) approach to family planning (FP). All staff located at nine randomly selected FP sites were trained and began app...περισσότερα »

Data of a willingness to pay survey for national climate change mitigation policies in Germany

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 37 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Reinhard UehlekeThe dataset includes responses from a contingent valuation of the national climate change mitigation policies in Germany. The online survey was carried out in the spring of 2014. It assesses the willingness to pay for an increase of the national CO2 reduction target by 10 percentage points, which closely represents Germany's climate change mitigation strategy. Respondents were randomly allocated to one of the following three question formats: The dichotomous choice referendum, the diss...περισσότερα »

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 37 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Babu A. Manjasetty, Andrei S. Halavaty, Chi-Hao Luan, Jerzy Osipiuk, Rory Mulligan, Keehwan Kwon, Wayne F. Anderson, Andrzej JoachimiakThe fluorescence-based thermal shift (FTS) data presented here include Table S1 and Fig. S1, and are supplemental to our original research article describing detailed structural, FTS, and fluorescence polarization analyses of the Salmonella enterica subsp. entrica serovar Typhimurium str. LT2 multidrug transcriptional regulator AcrR (StAcrR) (doi:10.1016/j.jsb.2016.01....περισσότερα »

Data for increase of Lymantria dispar male survival after topical application of single-stranded RING domain fragment of IAP-3 gene of its nuclear polyhedrosis virus

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 37 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Volodymyr V. Oberemok, Kateryna V. Laikova, Aleksei S. Zaitsev, Vladimir A. Gushchin, Oleksii A. SkorokhodThis data article is related to the research article entitled "The RING for gypsy moth control: topical application of fragment of its nuclear polyhedrosis virus anti-apoptosis gene as insecticide" [1]. This article reports on significantly higher survival of gypsy moth Lymantria dispar male individuals in response to topical application of single-stranded DNA, based on RING (really interesting ne...περισσότερα »

Data and the associated R code used to estimate health and economic burden of neurocysticercosis in India

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 37 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): B B Singh, M S Khatkar, J P S Gill, N K Dhand This article contains epidemiological, demographic and other data used for estimating health and economic burden of neurocysticercosis (NCC)-associated active epilepsy in India [1]. Most of the data are embedded in the R-code used for analyses so that the reader is able to replicate the results or adapt the code to their own data. However, data used to conduct sensitivity analyses to evaluate the effect of changing important input values such as prevalence ...περισσότερα »

Impulse noise injury prediction based on the cochlear energy

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Brissi Zagadou, Philemon Chan, Kevin Ho, David ShelleyThe current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk correlate (DRC). The model parameters have been corrected using the latest literature data. The anomalo...περισσότερα »

Disrupted Functional Brain Connectome in Unilateral Sudden Sensorineural Hearing Loss

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Haibo Xu, Wenliang Fan, Xueyan Zhao, Jing Li, Wenjuan Zhang, Ping Lei, Yuan Liu, Haha Wang, Huamao Cheng, Hong ShiSudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral sudden sensorineural hearing loss is still unknown, and the alterations ...περισσότερα »

Impulse noise injury prediction based on the cochlear energy

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Brissi Zagadou, Philemon Chan, Kevin Ho, David ShelleyThe current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk correlate (DRC). The model parameters have been corrected using the latest literature data. The anomalo...περισσότερα »

Disrupted Functional Brain Connectome in Unilateral Sudden Sensorineural Hearing Loss

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Haibo Xu, Wenliang Fan, Xueyan Zhao, Jing Li, Wenjuan Zhang, Ping Lei, Yuan Liu, Haha Wang, Huamao Cheng, Hong ShiSudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral sudden sensorineural hearing loss is still unknown, and the alterations ...περισσότερα »

Impulse noise injury prediction based on the cochlear energy

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Brissi Zagadou, Philemon Chan, Kevin Ho, David ShelleyThe current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk correlate (DRC). The model parameters have been corrected using the latest literature data. The anomalo...περισσότερα »

Disrupted Functional Brain Connectome in Unilateral Sudden Sensorineural Hearing Loss

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 40 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Haibo Xu, Wenliang Fan, Xueyan Zhao, Jing Li, Wenjuan Zhang, Ping Lei, Yuan Liu, Haha Wang, Huamao Cheng, Hong ShiSudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral sudden sensorineural hearing loss is still unknown, and the alterations ...περισσότερα »

Long noncoding RNAs related to the odontogenic potential of dental mesenchymal cells in mice

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 47 δευτερόλεπτα
Publication date: Available online 8 March 2016 *Source:*Archives of Oral BiologyAuthor(s): Yunfei Zheng, Lingfei Jia ObjectivesThe purpose of this study is to identify the lncRNAs that are associated with the odontogenic potential in mouse dental mesenchymal cells.DesignThe odontogenic potential of dental mesenchymal cells was found to be lost in the course of in vitro culture, so the lncRNA profiles were subsequently compared between freshly-isolated and cultured dental mesenchymal cells using RNA-sequencing. A co-expression analysis of differentially expressed lncRNAs and coding...περισσότερα »

Impulse noise injury prediction based on the cochlear energy

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 47 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Brissi Zagadou, Philemon Chan, Kevin Ho, David ShelleyThe current impulse noise criteria for the protection against impulse noise injury do not incorporate an objective measure of hearing protection. A new biomechanically-based model has been developed based on improvement of the Auditory Hazard Assessment Algorithm for the Human (AHAAH) using the integrated cochlear energy (ICE) as the damage risk correlate (DRC). The model parameters have been corrected using the latest literature data. The anoma...περισσότερα »

Disrupted Functional Brain Connectome in Unilateral Sudden Sensorineural Hearing Loss

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 47 δευτερόλεπτα
Publication date: Available online 9 March 2016 *Source:*Hearing ResearchAuthor(s): Haibo Xu, Wenliang Fan, Xueyan Zhao, Jing Li, Wenjuan Zhang, Ping Lei, Yuan Liu, Haha Wang, Huamao Cheng, Hong ShiSudden sensorineural hearing loss (SSNHL) is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period. This hearing loss is usually unilateral and can be associated with tinnitus and vertigo. The pathogenesis of unilateral sudden sensorineural hearing loss is still unknown, and the alteration...περισσότερα »

Long noncoding RNAs related to the odontogenic potential of dental mesenchymal cells in mice

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 52 δευτερόλεπτα
Publication date: Available online 8 March 2016 *Source:*Archives of Oral BiologyAuthor(s): Yunfei Zheng, Lingfei Jia ObjectivesThe purpose of this study is to identify the lncRNAs that are associated with the odontogenic potential in mouse dental mesenchymal cells.DesignThe odontogenic potential of dental mesenchymal cells was found to be lost in the course of in vitro culture, so the lncRNA profiles were subsequently compared between freshly-isolated and cultured dental mesenchymal cells using RNA-sequencing. A co-expression analysis of differentially expressed lncRNAs and coding...περισσότερα »

Survival of smear-positive multidrug resistant tuberculosis patients in Witbank, South Africa: A retrospective cohort study

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 53 δευτερόλεπτα
10.3109/23744235.2016.1153806<br>Abiola O. Olaleyefrom Infection via ola Kala on Inoreader http://ift.tt/1R6fXvDvia IFTTT

IL-10-Expressing Th2 Cells Contribute to the Elevated Antibody Production in Rheumatoid Arthritis

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 53 δευτερόλεπτα
Abstract Rheumatoid arthritis (RA) is a common autoimmune disease associated with progressive disability, systemic complications, and early death. Multiple lines of evidence have placed adaptive immune responses in the center of RA pathogenesis. However, the functional roles of T helper cells are insufficiently described. Here, we examined the Th2 cell subsets and their functions in RA patients. A downregulation of IL-4+ cells in CD4+ T cells were observed in RA patients, indicating a downregulation of Th2 cells, and these results were confirmed by using and CXCR3 and CCR6 surface ...περισσότερα »

Ti guardi allo specchio e non riconosci pi il tuo seno Masto Cod: 885

MASTOPESSI IL LIFTING DEL SENO A PERUGIA quot:(Può accadere che il seno perda nel tempo tonicità e che assuma una forma più allungata -Ptosi mammaria-. Solitamente le cause sono varie tra le quali: – gravidanza – allattamento – perdita o aumento di peso – naturale processo di invecchiamento) Ci si trova quindi di fronte ad […]

Linking Quality of Work in Midlife to Volunteering During Retirement: a European Study

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract There is increasing recognition that disadvantaged work and employment conditions over the life course, including psychosocial stress at work, have negative long-term effects on health at older ages. Yet, the question whether stress at work additionally influences the likelihood of participating in voluntary work during retirement still needs to be explored. This paper studies… Continue reading Linking Quality of Work in Midlife to Volunteering During Retirement: a European Study

Work-Family Life Courses and Subjective Wellbeing in the MRC National Survey of Health and Development (the 1946 British birth cohort study)

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Studies investigating the impact of combining paid work and family life on wellbeing have generally used information at one or a limited number of points in the life course, and have mainly focused on women. This study uses multi-channel sequence analysis to characterise work-family life courses across adulthood (ages 16–60) for more than 1500… Continue reading Work-Family Life Courses and Subjective Wellbeing in the MRC National Survey of Health and Development (the 1946 British birth cohort study)

Introducing the New Book Review Section

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1p7u39r via IFTTT

Trajectories in the Prevalence of Self-Reported Illness Around Retirement

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract In this paper we used wave 1 (2002) to wave 6 (2012) of the English Longitudinal Study of Ageing (ELSA) to assess whether trajectories in the prevalence of self-reported limiting long term illness differed before and after retirement and whether any such differences in slope were found across socio-economic characteristics and the conditions of… Continue reading Trajectories in the Prevalence of Self-Reported Illness Around Retirement

Erratum to: Life Course Influences on Inequalities in Later Life: Comparative Perspectives

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1p7u2SZ via IFTTT

Support in the East Riding to Kick Smoking Habit – Yorkshire Coast Radio

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Yorkshire Coast Radio Support in the East Riding to Kick Smoking Habit Yorkshire Coast Radio While most smokers know about the link between smoking and lung cancer, many people do not realise that smoking is linked with not one but 16 different cancers, including cancers of the mouth, nasal cavities, pharynx and larynx, stomach, kidney,… Continue reading Support in the East Riding to Kick Smoking Habit – Yorkshire Coast Radio

Revolutionary Therapies and Manipulation of Nanoparticles to Cure Cancer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
The post Revolutionary Therapies and Manipulation of Nanoparticles to Cure Cancer appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1R77Ncx via IFTTT

IJMS, Vol. 17, Pages 355: Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple steatosis and steatohepatitis) and non-fatty liver changes (NASH-cirrhosis with or without hepatocellular… Continue reading IJMS, Vol. 17, Pages 355: Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight

IJMS, Vol. 17, Pages 354: Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Nonalcoholic beverages are usually consumed accompanying alcoholic drinks, and their effects on alcohol metabolism are unclear in vivo. In this study, the effects of 20 nonalcoholic beverages on alcohol metabolism and liver injury caused by alcohol were evaluated in mice. Kunming mice were orally fed with alcohol (52%, v/v) and beverages. The concentrations of ethanol… Continue reading IJMS, Vol. 17, Pages 354: Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts

IJMS, Vol. 17, Pages 205: Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protopanaxadiol in Human Liver Microsomes

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
20(S)-protopanaxadiol (PPD), one of the representative aglycones of ginsenosides, has a broad spectrum of pharmacological activities. Although phase I metabolism has been investigated extensively, information regarding phase II metabolism of this compound remains to be elucidated. Here, a glucuronidated metabolite of PPD in human liver microsomes (HLMs) and rat liver microsomes (RLMs) was unambiguously identified… Continue reading IJMS, Vol. 17, Pages 205: Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protop...περισσότερα »

Using Behavioral Risk Factor Data as a surveillance tool to monitor the prevalence of initiation, continuation and completion of Human Papilloma Virus Vaccination in Children

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Gia Elise Barboza, Silvia DominguezThe Human Papilloma Virus ("HPV") is a common sexually transmitted disease that has infected approximately 79 million men and women in the United States alone. A vaccination is available but in order to be effective it must be received prior to becoming sexually active and recipients must complete a three-dose sequence. In this article we explore the predisposing, enabling and need-based factors associated with parents' or guardians' decision to have their child init...περισσότερα »

Atypical carcinoid and large cell neuroendocrine carcinoma of the lung: a proteomic dataset from formalin-fixed archival samples

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 1 ώρα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Alessandro Tanca, Maria Filippa Addis, Salvatore Pisanu, Marcello Abbondio, Daniela Pagnozzi, Albino Eccher, Guido Rindi, Paolo Cossu-Rocca, Sergio Uzzau, Giuseppe FanciulliHere we present a dataset generated using formalin-fixed paraffin-embedded archival samples from two rare lung neuroendocrine tumor subtypes (namely, two atypical carcinoids, ACs, and two large-cell neuroendocrine carcinomas, LCNECs). Samples were subjected to a shotgun proteomics pipeline, comprising full-length protein extraction...περισσότερα »

Understanding the occupational traveller profile towards malaria prevention enables directed health promotion and preventive practices

2016-03-09T02-58-29Z*Source:* International Journal of Tropical Medicine and Public HealthAna Gloria Fonseca, Susana Carvalho, Sara Simões Dias, Joao Luis Baptista, Jorge Torgal.Aim/background: Increased migration and expatriation to malaria endemic countries has been appointed as contributing factor to the increasing imported malaria hospitalizations recently observed in Portugal. This study sought to profile this traveller and understand the knowledge, attitude and practice (KAP) towards malaria prevention as necessary first step to improve and suit risk reduction strategies. M...περισσότερα »

IJMS, Vol. 17, Pages 205: Identification of Human UDP-Glucuronosyltransferase 1A4 as the Major Isozyme Responsible for the Glucuronidation of 20(S)-Protopanaxadiol in Human Liver Microsomes

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
20(S)-protopanaxadiol (PPD), one of the representative aglycones of ginsenosides, has a broad spectrum of pharmacological activities. Although phase I metabolism has been investigated extensively, information regarding phase II metabolism of this compound remains to be elucidated. Here, a glucuronidated metabolite of PPD in human liver microsomes (HLMs) and rat liver microsomes (RLMs) was unambiguously identified as PPD-3-O-β-d-glucuronide by nuclear magnetic resonance spectroscopy and high resolution mass spectrometry. The chemical inhibition and recombinant human UDP-Glucuronosy...περισσότερα »

Marine Drugs, Vol. 14, Pages 52: Antimicrobial Action of Compounds from Marine Seaweed

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Seaweed produces metabolites aiding in the protection against different environmental stresses. These compounds show antiviral, antiprotozoal, antifungal, and antibacterial properties. Macroalgae can be cultured in high volumes and would represent an attractive source of potential compounds useful for unconventional drugs able to control new diseases or multiresistant strains of pathogenic microorganisms. The substances isolated from green, brown and red algae showing potent antimicrobial activity belong to polysaccharides, fatty acids, phlorotannins, pigments, lectins, alkaloids,...περισσότερα »

Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
*Background:* Huntington's disease is induced by CAG expansion in a single gene coding the huntingtin protein. The mutated huntingtin (mtHtt) primarily causes degeneration of neurons in the brain, but it also affects peripheral tissues, including testes. *Objective:* We studied sperm and testes of transgenic boars expressing the N-terminal region of human mtHtt. *Methods:* In this study, measures of reproductive parameters and electron microscopy (EM) images of spermatozoa and testes of transgenic (TgHD) and wild-type (WT) boars of F1 (24-48 months old) and F2 (12-36 months old) gen...περισσότερα »

Anti-HMG-CoA Reductase, Antioxidant, and Anti-Inflammatory Activities of Amaranthus viridis Leaf Extract as a Potential Treatment for Hypercholesterolemia

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Inflammation and oxidative stress are believed to contribute to the pathology of several chronic diseases including hypercholesterolemia (elevated levels of cholesterol in blood) and atherosclerosis. HMG-CoA reductase inhibitors of plant origin are needed as synthetic drugs, such as statins, which are known to cause adverse effects on the liver and muscles. Amaranthus viridis (A. viridis) has been used from ancient times for its supposedly medically beneficial properties. In the current study, different parts of A. viridis (leaf, stem, and seed) were evaluated for potential anti-H...περισσότερα »

Effect of Laser Acupuncture on Anthropometric Measurements and Appetite Sensations in Obese Subjects

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Purpose. A patient-assessor-blinded, randomized, sham-controlled crossover trial was performed to investigate the effectiveness of laser acupuncture on anthropometric measurements and appetite sensation in obese subjects. Methods. Fifty-two obese subjects were randomly assigned to either the laser acupuncture group or the sham laser acupuncture group. Subjects within each group received the relevant treatment three times a week for 8 weeks. After a two-week washout period, the subjects then received the treatment of the opposite group for another 8 weeks. BMI, body fat percentage,...περισσότερα »

IJMS, Vol. 17, Pages 355: Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection—Liver: The “Musketeer” in the Spotlight

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple steatosis and steatohepatitis) and non-fatty liver changes (NASH-cirrhosis with or without hepatocellular carcinoma (HCC)) that are commonly observed among individuals with multiple metabolic derangements, notably including visceral obesity, IR and T2D. Hepatitis C virus ...περισσότερα »

Nanomaterials, Vol. 6, Pages 47: Copper Nanowires and Their Applications for Flexible, Transparent Conducting Films: A Review

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Cu nanowires (NWs) are attracting considerable attention as alternatives to Ag NWs for next-generation transparent conductors, replacing indium tin oxide (ITO) and micro metal grids. Cu NWs hold great promise for low-cost fabrication via a solution-processed route and show preponderant optical, electrical, and mechanical properties. In this study, we report a summary of recent advances in research on Cu NWs, covering the optoelectronic properties, synthesis routes, deposition methods to fabricate flexible transparent conducting films, and their potential applications. This review ...περισσότερα »

Gels, Vol. 2, Pages 11: Effect of Granule Sizes on Acoustic Properties of Protein-Based Silica Aerogel Composites via Novel Inferential Transmission Loss Method

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
The acoustic properties of the silica aerogel (SA) granules of various sizes from 0.50 to 3.35 mm, distributed into six groups of nominal sizes and measured via a two-microphone impedance tube, are presented. The absorption coefficients of the SA granules were evaluated at ultra- to super-low frequency range from 50–1600 Hz. It was observed that nominal SA granules with sizes of 1.2 mm (AG2) and 1.7 mm (AG3) displayed the best absorption coefficients. When tested with granules filled at 5 cm depth, AG2 and AG3 absorption coefficients peaked at 980 Hz with values of 0.86 and 0.81, ...περισσότερα »

Molecules, Vol. 21, Pages 315: Isolation, Purification and Quantification of Ginsenoside F5 and F3 Isomeric Compounds from Crude Extracts of Flower Buds of Panax ginseng

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
In this paper, the isolation, purification and quantification of ginsenoside F5 and F3 isomeric compounds from crude extracts of flower buds of Panax ginseng (CEFBPG) was investigated by reversed-phase high-performance liquid chromatography (RP-HPLC) for the first time. The satisfied separation at analytical scale was achieved using a Zorbax Eclipse XDB C-18 column with a ternary mobile phase of acetonitrile–water–phosphoric acid (28:71:1) at a flow rate of 1.0 mL/min within 40 min. UV detection was set at 203 nm. Ginsenoside F5 and F3 was 4.21 mg and 5.13 mg in 1 g flower buds of...περισσότερα »

Sensors, Vol. 16, Pages 354: A Dynamic Instrumentation Amplifier for Low-Power and Low-Noise Biopotential Acquisition

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
A low-power and low-noise dynamic instrumentation amplifier (IA) for biopotential acquisition is presented. A dynamic IA that can reduce power consumption with a timely piecewise power-gating method, and noise level with an alternating input and chopper stabilization technique is fabricated with a 0.13-μm CMOS. Using the reconfigurable architecture of the IA, various combinations of the low-noise schemes are investigated. The combination of power gating and chopper stabilization shows a lower noise performance than the combination of power gating and alternating input switching sc...περισσότερα »

Agronomy, Vol. 6, Pages 19: Root Exudation: The Ecological Driver of Hydrocarbon Rhizoremediation

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Rhizoremediation is a bioremediation technique whereby microbial degradation of organic contaminants occurs in the rhizosphere. It is considered to be an effective and affordable "green technology" for remediating soils contaminated with petroleum hydrocarbons. Root exudation of a wide variety of compounds (organic, amino and fatty acids, carbohydrates, vitamins, nucleotides, phenolic compounds, polysaccharides and proteins) provide better nutrient uptake for the rhizosphere microbiome. It is thought to be one of the predominant drivers of microbial communities in the rhizosphere ...περισσότερα »

Nanomaterials, Vol. 6, Pages 44: High Refractive Organic–Inorganic Hybrid Films Prepared by Low Water Sol-Gel and UV-Irradiation Processes

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Organic-inorganic hybrid sols (Ti–O–Si precursor) were first synthesized by the sol-gel method at low addition of water, and were then employed to prepare a highly refractive hybrid optical film. This film was obtained by blending the Ti–O–Si precursor with 2-phenylphenoxyethyl acrylate (OPPEA) to perform photo-polymerization by ultraviolet (UV) irradiation. Results show that the film transparency of poly(Ti–O–Si precursor-co-OPPEA) film is higher than that of a pure poly(Ti–O–Si precursor) film, and that this poly(Ti–O–Si precursor-co-OPPEA) hybrid film exhibits a high transparenc...περισσότερα »

Actuators, Vol. 5, Pages 9: Status and Perspectives of Multiferroic Magnetoelectric Composite Materials and Applications

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Multiferroic magnetoelectric (ME) composites are attractive materials for various electrically and magnetically cross-coupled devices. Many studies have been conducted on fundamental understanding, fabrication processes, and applications of ME composite material systems in the last four decades which has brought the technology closer to realization in practical devices. In this article, we present a review of ME composite materials and some notable potential applications based upon their properties. A brief summary is presented on the parameters that influence the performance of ME...περισσότερα »

Marine Drugs, Vol. 14, Pages 53: Heterotrophic Production of Omega-3 Long-Chain Polyunsaturated Fatty Acids by Trophically Converted Marine Diatom Phaeodactylum tricornutum

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
We have created via metabolic engineering a heterotrophic strain of Phaeodactylum tricornutum that accumulates enhanced levels of the high value omega-3 long chain polyunsaturated fatty acid (LC-PUFAs) docosahexaenoic acid (DHA). This was achieved by generation of transgenic strains in which the Δ5-elongase from Ostreococcus tauri was co-expressed with a glucose transporter from the moss Physcomitrella patens. This double transformant has the capacity to grow in the dark in liquid medium supplemented with glucose and accumulate substantial levels of omega-3 LC-PUFAs. The effects o...περισσότερα »

Partial Response to First-Line Crizotinib in an Elderly Male Patient with ROS1 Translocation-Positive Lung Cancer

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
We report on a 90-year-old male patient with a *ROS1*-translocated adenocarcinoma of the lung who was treated with crizotinib as first-line therapy. After 11 months of treatment, we noticed complete metabolic response as measured by 18F-FDG-PET/CT scan and a partial response according to RECIST criteria. This patient indicates that *ROS1* translocations are not restricted to young age, female gender and low stage. Furthermore, this case illustrates exemplarily that crizotinib therapy is effective and manageable even as first-line treatment in elderly patients with comorbidities. B...περισσότερα »

Immune Reactivity and Pseudoprogression or Tumor Flare in a Serially Biopsied Neuroendocrine Patient Treated with the Epigenetic Agent RRx-001

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Neuroendocrine tumors (NETs) are grouped together as a single class on the basis of histologic appearance, immunoreactivity for the neuroendocrine markers chromogranin A and synaptophysin, and potential secretion of hormones, neurotransmitters, neuromodulators and neuropeptides. Nevertheless, despite these common characteristics, NETs differ widely in terms of their natural histories: high-grade NETs are clinically aggressive and, like small cell lung cancer, which they most closely resemble, tend to respond to cisplatin and etoposide. In contrast, low-grade NETs, which as a rule ...περισσότερα »

Data of a willingness to pay survey for national climate change mitigation policies in Germany

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Reinhard UehlekeThe dataset includes responses from a contingent valuation of the national climate change mitigation policies in Germany. The online survey was carried out in the spring of 2014. It assesses the willingness to pay for an increase of the national CO2 reduction target by 10 percentage points, which closely represents Germany's climate change mitigation strategy. Respondents were randomly allocated to one of the following three question formats: The dichotomous choice referendum, the diss...περισσότερα »

Fluorescence-based thermal shift data on multidrug regulator AcrR from Salmonella enterica subsp. entrica serovar Typhimurium str. LT2

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Babu A. Manjasetty, Andrei S. Halavaty, Chi-Hao Luan, Jerzy Osipiuk, Rory Mulligan, Keehwan Kwon, Wayne F. Anderson, Andrzej JoachimiakThe fluorescence-based thermal shift (FTS) data presented here include Table S1 and Fig. S1, and are supplemental to our original research article describing detailed structural, FTS, and fluorescence polarization analyses of the Salmonella enterica subsp. entrica serovar Typhimurium str. LT2 multidrug transcriptional regulator AcrR (StAcrR) (doi:10.1016/j.jsb.2016.01....περισσότερα »

Data for increase of Lymantria dispar male survival after topical application of single-stranded RING domain fragment of IAP-3 gene of its nuclear polyhedrosis virus

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Volodymyr V. Oberemok, Kateryna V. Laikova, Aleksei S. Zaitsev, Vladimir A. Gushchin, Oleksii A. SkorokhodThis data article is related to the research article entitled "The RING for gypsy moth control: topical application of fragment of its nuclear polyhedrosis virus anti-apoptosis gene as insecticide" [1]. This article reports on significantly higher survival of gypsy moth Lymantria dispar male individuals in response to topical application of single-stranded DNA, based on RING (really interesting ne...περισσότερα »

Data and the associated R code used to estimate health and economic burden of neurocysticercosis in India

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): B B Singh, M S Khatkar, J P S Gill, N K Dhand This article contains epidemiological, demographic and other data used for estimating health and economic burden of neurocysticercosis (NCC)-associated active epilepsy in India [1]. Most of the data are embedded in the R-code used for analyses so that the reader is able to replicate the results or adapt the code to their own data. However, data used to conduct sensitivity analyses to evaluate the effect of changing important input values such as prevalence ...περισσότερα »

Using Behavioral Risk Factor Data as a surveillance tool to monitor the prevalence of initiation, continuation and completion of Human Papilloma Virus Vaccination in Children

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Gia Elise Barboza, Silvia DominguezThe Human Papilloma Virus ("HPV") is a common sexually transmitted disease that has infected approximately 79 million men and women in the United States alone. A vaccination is available but in order to be effective it must be received prior to becoming sexually active and recipients must complete a three-dose sequence. In this article we explore the predisposing, enabling and need-based factors associated with parents' or guardians' decision to have their child init...περισσότερα »

Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Vestibular migraine (VM), defined as vestibular symptoms caused by migraine mechanisms, is very common but poorly understood. Because dizziness is often provoked in VM patients when the semicircular canals and otolith organs are stimulated concurrently (e.g., tilting the head relative to gravity), we measured tilt perception and eye movements in patients with VM and in migraine and normal control subjects during fixed-radius centrifugation, a paradigm that simultaneously modulates afferent signals from the semicircular canals and otoliths organs. Twenty-four patients (8 i...περισσότερα »

Cadaveric Study of an Endoscopic Keyhole Middle Fossa Craniotomy Approach to the Superior Semicircular Canal.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Objective: Demonstrate that an endoscopic keyhole approach to the middle cranial fossa is technically feasible for repair of semicircular canal dehiscence. Study Design: Cadaveric technical feasibility/methods development study. Setting: Tertiary care military medical center. Patients: Three fresh cadaveric heads (six sides). Intervention(s): Endoscopic minimally invasive approach to the middle cranial fossa using the Medtronic Fusion Guidance system. Main Outcome Measure(s): Ability to identify the surgical landmarks of the middle cranial fossa and successfully identify and instrum...περισσότερα »

Quantitative Analysis of Psychiatric Disorders in Intractable Peripheral Vertiginous Patients: A Prospective Study.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Objective: To investigate the correlation between psychological disorder and vestibular dysfunction in patients suffering from intractable peripheral vertigo. Study Design: Prospective study. Setting: In-patients in a university hospital. Methods: Prospective design of 26 intractable peripheral vertiginous patients with peripheral vestibular dysfunction and 20 controls recruited from the EENT hospital. Hospital Anxiety and Depression scale, Self-rating Anxiety scale, Self-rating Depression scale, Symptom Checklist-90 were used in this study. All vertigo patients received intratympan...περισσότερα »

Histopathologic Diagnosis of Multifactorial Alopecia

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Establishing a definitive diagnosis for any form of alopecia can be challenging. Adding to the diagnostic complexity is the fact that many patients have more than one form of alopecia contributing to their hair loss. We conducted a review of 1360 consecutive scalp biopsy specimens submitted for the evaluation of scalp hair loss over a 16-month period, demonstrating that 12.5% of cases had a combination of diagnoses (multifactorial alopecia) accounting for their hair loss. An approach to the histopathologic diagnosis of multifactorial alopecia, particularly multiple forms ...περισσότερα »

Revisiting histopathologic findings in Goltz syndrome

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Goltz syndrome (focal dermal hypoplasia) is an X-linked dominant disorder that is classically associated with yellowish papules representing fat herniation (superficial adipocytes). We report a series of 3 cases, with clinicopathologic correlation of biopsies from Blaschkoid streaks. A range of histopathologic features, including some underreported findings (increased papillary dermal blood vessels, decreased thickness of the dermis, and adipocytes high in the dermis), are reproducible and can strongly point to the correct diagnosis of Goltz syndrome.from Anatomy Pathol...περισσότερα »

Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
ABSTRACT Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear cells, such as squamous cell carcinoma, basal cell carcinoma, metastatic renal cell carcinoma, and balloon cell malignant melanoma. These diagnoses can b...περισσότερα »

Skin involvement as the first manifestation of breast implant-associated anaplastic large cell lymphoma

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Breast implant–associated large cell anaplastic lymphoma (ALCL) is a newly described clinical and pathologic entity that typically presents as seroma in the fibrous scar around the implant. Less frequently, it presents as a solid peri-implant mass, and there have been no reports to date of cutaneous lesions as the presenting manifestation.We report the case of a 56-year-old woman with a history of bilateral breast reconstruction following breast cancer of the right breast who consulted with several papules on the right breast suggestive of metastasis. Histopathology show...περισσότερα »

Polymorphous sweat gland carcinoma: a report of two cases

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
ABSTRACT Polymorphous sweat gland carcinoma (PSGC) is a rare adnexal neoplasm with characteristic variegated histopathologic findings and low-grade clinical behavior. First described in 1994, only eleven cases have been reported in the literature. It is named for the multiplicity of architectural patterns that may be present: solid, tubular, trabecular, pseudopapillary and cylindromatous. Due to the multiple architectural patterns, the differential diagnosis is broad, including metastatic adenocarcinoma and other adnexal neoplasms with ductular differentiation. We present two new ...περισσότερα »

Pigmented Desmoplastic trichilemmoma

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1W8eBVIvia IFTTT

Postirradiation pseudosclerodermatous panniculitis with involvement of breast parenchyma: A dramatic example of a rare entity and a pitfall in diagnosis

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Postirradiation pseudosclerodermatous panniculitis is a rare complication of external beam radiotherapy. This inflammatory process typically presents as an erythematous indurated plaque in a previously irradiated region of skin. To date, 13 cases have been reported worldwide. We present a case of a 70 year-old female who received breast irradiation following conservation surgery for invasive breast carcinoma. In her third year of follow-up she developed an enlarging mass, involving the subcutis and underlying breast tissue, associated with mammographically-detected coarse ...περισσότερα »

Histopathology of keratotic papules of the limbs in frontal fibrosing alopecia

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Frontal fibrosing alopecia (FFA) is a scarring type of alopecia that presents clinically as progressive frontotemporal hairline regression and eyebrow loss, mainly in postmenopausal women. An additional common finding is keratotic papules on the face or (less commonly) on the trunk and extremities. The histopathology of the facial keratotic papules associated with FFA is the same as that of lichen planopilaris. There are very few FFA cases with biopsies from extrafacial sites and no cases of folliculocentric keratotic papules with biopsies from extrafacial sites. In the cu...περισσότερα »

Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Rheumatoid vasculitis (RV) is one of the most serious extra-articular complications of rheumatoid arthritis (RA), generally treated with a high dose of immunosuppressive drugs. Recently, we encountered two cases of ulcerative vasculitis in methotrexate (MTX)-prescribed RA patients, which simulated RV; however, Epstein-Barr virus (EBV)-encoded RNA *in situ* hybridization on their skin biopsies revealed many EBV-positive lymphocytes (over 50 cells/high-power field) within the vessel walls and perivascular stroma, which led us to the diagnosis of EBV-related vasculitis instea...περισσότερα »

Spindle B-cell lymphoma: a rare variant of follicle center lymphoma

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Primary cutaneous follicle center lymphoma (PCFCL) is a common subtype of primary cutaneous B-cell lymphoma (PCBCL). The prognosis of this subtype is favorable and recurrence is observed in up to 50% of patients. The dissemination to lymph nodes or internal organs is rare. In this study, two cases of rare variant of PCFCL are reported. Both cases presented with multiple erythematous nodules , plaques and some annular configurations . Histopathological examination revealed dermal lymphocytic infiltrates consisting of admixed centrocytes and centroblasts. Interestingly, spi...περισσότερα »

Eruptive Angiokeratomas and Porokeratosis in the setting of Sclerodermatous Graft-Versus-Host Disease

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Porokeratosis and angiokeratomas are both seen in the setting of chronic graft-versus-host-disease (GVHD), but rarely occur together. We present a case of a patient with lichen planus-like (LPL) and sclerodermatous chronic GVHD manifesting after allogeneic bone marrow transplant with concomitant eruptive angiokeratomas and porokeratosis.from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/1US31Q7via IFTTT

An unusual presentation of Dermatofibrosarcoma Protuberans with pleomorphic sarcomatous transformation: potential pitfall and diagnostic strategy

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
Abstract Dermatofibrosarcoma protuberans (DFSP) is a low grade, superficial sarcoma characterized by a proliferation of monomorphous, spindle cells arranged in a storiform pattern and infiltrating the subcutaneous tissue. The tumor is typically CD34 positive, and shows the characteristic COL1A1-PDGFB fusion gene, detectable either by FISH and PCR. We describe a case of DFSP with a focus of peculiar pleomorphic sarcomatous transformation. The focus constituted the entire bioptic tissue that was initially excised, raising considerable diagnostic problems for pathologist. The use of F...περισσότερα »

HLA-DMB in Amerindians: specific linkage of DMB∗01:03:01/DRB1 alleles.

CONCLUSION: The specific Amerindian HLA-DMB allele frequencies and their linkage disequilibrium with other MHC alleles may be crucial to determine HLA-DMB World wide variation, evolution and specific linkage to disease in Amerindians and other populations. PMID: 26944519 [PubMed – as supplied by publisher] (Source: Human Immunology) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1YvXcaI via IFTTT […]

Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars

Background: Huntington’s disease is induced by CAG expansion in a single gene coding the huntingtin protein. The mutated huntingtin (mtHtt) primarily causes degeneration of neurons in the brain, but it also affects peripheral tissues, including testes. Objective: We studied sperm and testes of transgenic boars expressing the N-terminal region of human mtHtt. Methods: In this […]

5-Methylcytosine-Rich Heterochromatin in the Indian Muntjac

Two 5-methylcytosine (5-MeC)-rich heterochromatic regions were demonstrated in metaphase chromosomes of the Indian muntjac by indirect immunofluorescence using a monoclonal anti-5-MeC antibody. The metaphases were obtained from diploid and triploid cell lines. A major region is located in the ‘neck’ of the 3;X fusion chromosome and can be detected after denaturation of the chromosomal DNA […]

Atypical carcinoid and large cell neuroendocrine carcinoma of the lung: a proteomic dataset from formalin-fixed archival samples

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 1 ώρα
Publication date: Available online 9 March 2016 *Source:*Data in BriefAuthor(s): Alessandro Tanca, Maria Filippa Addis, Salvatore Pisanu, Marcello Abbondio, Daniela Pagnozzi, Albino Eccher, Guido Rindi, Paolo Cossu-Rocca, Sergio Uzzau, Giuseppe FanciulliHere we present a dataset generated using formalin-fixed paraffin-embedded archival samples from two rare lung neuroendocrine tumor subtypes (namely, two atypical carcinoids, ACs, and two large-cell neuroendocrine carcinomas, LCNECs). Samples were subjected to a shotgun proteomics pipeline, comprising full-length protein extraction...περισσότερα »

Histopathologic Diagnosis of Multifactorial Alopecia

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Establishing a definitive diagnosis for any form of alopecia can be challenging. Adding to the diagnostic complexity is the fact that many patients have more than one form of alopecia contributing to their hair loss. We conducted a review of 1360 consecutive scalp biopsy specimens submitted for the evaluation of scalp hair loss over a 16-month period, demonstrating that 12.5% of cases had a combination of diagnoses (multifactorial alopecia) accounting for their hair loss. An approach to the histopathologic diagnosis of multifactorial alopecia, particularly multiple forms ...περισσότερα »

Revisiting histopathologic findings in Goltz syndrome

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Goltz syndrome (focal dermal hypoplasia) is an X-linked dominant disorder that is classically associated with yellowish papules representing fat herniation (superficial adipocytes). We report a series of 3 cases, with clinicopathologic correlation of biopsies from Blaschkoid streaks. A range of histopathologic features, including some underreported findings (increased papillary dermal blood vessels, decreased thickness of the dermis, and adipocytes high in the dermis), are reproducible and can strongly point to the correct diagnosis of Goltz syndrome.from #Dermatology v...περισσότερα »

Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
ABSTRACT Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear cells, such as squamous cell carcinoma, basal cell carcinoma, metastatic renal cell carcinoma, and balloon cell malignant melanoma. These diagnoses can b...περισσότερα »

Skin involvement as the first manifestation of breast implant-associated anaplastic large cell lymphoma

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Breast implant–associated large cell anaplastic lymphoma (ALCL) is a newly described clinical and pathologic entity that typically presents as seroma in the fibrous scar around the implant. Less frequently, it presents as a solid peri-implant mass, and there have been no reports to date of cutaneous lesions as the presenting manifestation.We report the case of a 56-year-old woman with a history of bilateral breast reconstruction following breast cancer of the right breast who consulted with several papules on the right breast suggestive of metastasis. Histopathology show...περισσότερα »

Polymorphous sweat gland carcinoma: a report of two cases

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
ABSTRACT Polymorphous sweat gland carcinoma (PSGC) is a rare adnexal neoplasm with characteristic variegated histopathologic findings and low-grade clinical behavior. First described in 1994, only eleven cases have been reported in the literature. It is named for the multiplicity of architectural patterns that may be present: solid, tubular, trabecular, pseudopapillary and cylindromatous. Due to the multiple architectural patterns, the differential diagnosis is broad, including metastatic adenocarcinoma and other adnexal neoplasms with ductular differentiation. We present two new ...περισσότερα »

Pigmented Desmoplastic trichilemmoma

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1W8eBVIvia IFTTT

Postirradiation pseudosclerodermatous panniculitis with involvement of breast parenchyma: A dramatic example of a rare entity and a pitfall in diagnosis

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Postirradiation pseudosclerodermatous panniculitis is a rare complication of external beam radiotherapy. This inflammatory process typically presents as an erythematous indurated plaque in a previously irradiated region of skin. To date, 13 cases have been reported worldwide. We present a case of a 70 year-old female who received breast irradiation following conservation surgery for invasive breast carcinoma. In her third year of follow-up she developed an enlarging mass, involving the subcutis and underlying breast tissue, associated with mammographically-detected coarse ...περισσότερα »

Histopathology of keratotic papules of the limbs in frontal fibrosing alopecia

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Frontal fibrosing alopecia (FFA) is a scarring type of alopecia that presents clinically as progressive frontotemporal hairline regression and eyebrow loss, mainly in postmenopausal women. An additional common finding is keratotic papules on the face or (less commonly) on the trunk and extremities. The histopathology of the facial keratotic papules associated with FFA is the same as that of lichen planopilaris. There are very few FFA cases with biopsies from extrafacial sites and no cases of folliculocentric keratotic papules with biopsies from extrafacial sites. In the cu...περισσότερα »

Methotrexate-associated EBV-positive vasculitis in the skin: a report of two cases simulating rheumatoid vasculitis

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Rheumatoid vasculitis (RV) is one of the most serious extra-articular complications of rheumatoid arthritis (RA), generally treated with a high dose of immunosuppressive drugs. Recently, we encountered two cases of ulcerative vasculitis in methotrexate (MTX)-prescribed RA patients, which simulated RV; however, Epstein-Barr virus (EBV)-encoded RNA *in situ* hybridization on their skin biopsies revealed many EBV-positive lymphocytes (over 50 cells/high-power field) within the vessel walls and perivascular stroma, which led us to the diagnosis of EBV-related vasculitis instea...περισσότερα »

Spindle B-cell lymphoma: a rare variant of follicle center lymphoma

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Primary cutaneous follicle center lymphoma (PCFCL) is a common subtype of primary cutaneous B-cell lymphoma (PCBCL). The prognosis of this subtype is favorable and recurrence is observed in up to 50% of patients. The dissemination to lymph nodes or internal organs is rare. In this study, two cases of rare variant of PCFCL are reported. Both cases presented with multiple erythematous nodules , plaques and some annular configurations . Histopathological examination revealed dermal lymphocytic infiltrates consisting of admixed centrocytes and centroblasts. Interestingly, spi...περισσότερα »

Eruptive Angiokeratomas and Porokeratosis in the setting of Sclerodermatous Graft-Versus-Host Disease

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Porokeratosis and angiokeratomas are both seen in the setting of chronic graft-versus-host-disease (GVHD), but rarely occur together. We present a case of a patient with lichen planus-like (LPL) and sclerodermatous chronic GVHD manifesting after allogeneic bone marrow transplant with concomitant eruptive angiokeratomas and porokeratosis.from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1US31Q7via IFTTT

An unusual presentation of Dermatofibrosarcoma Protuberans with pleomorphic sarcomatous transformation: potential pitfall and diagnostic strategy

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Abstract Dermatofibrosarcoma protuberans (DFSP) is a low grade, superficial sarcoma characterized by a proliferation of monomorphous, spindle cells arranged in a storiform pattern and infiltrating the subcutaneous tissue. The tumor is typically CD34 positive, and shows the characteristic COL1A1-PDGFB fusion gene, detectable either by FISH and PCR. We describe a case of DFSP with a focus of peculiar pleomorphic sarcomatous transformation. The focus constituted the entire bioptic tissue that was initially excised, raising considerable diagnostic problems for pathologist. The use of F...περισσότερα »

Abnormal Tilt Perception During Centrifugation in Patients with Vestibular Migraine

Abstract Vestibular migraine (VM), defined as vestibular symptoms caused by migraine mechanisms, is very common but poorly understood. Because dizziness is often provoked in VM patients when the semicircular canals and otolith organs are stimulated concurrently (e.g., tilting the head relative to gravity), we measured tilt perception and eye movements in patients with VM and […]

ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes

Abstract Background Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioactivity and an efficient workflow. For this purpose, we have designed ARAS, an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes with particular […]

A call for specific geriatric data on cervical cancers

Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1LQId9E via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 &amp; 00306932607174

Pharmacokinetics of Immediate and Sustained Release Cephalexin Administered by Different Routes to Llamas (Lama glama)

Alexandros G. SfakianakisστοΘεραπείαΠριν από 1 ώρα
We investigate the pharmacokinetics of two different cephalexin formulations administered to llamas by the intravenous (IV), intramuscular (IM), and subcutaneous (SC) routes, the minimum inhibitory concentration (MIC) of cephalexin against some Escherichia coli and staphylococci isolated from llamas, and we apply the PK/PD modelling approach, so that effective dosage recommendations for this species could be made. Six llamas received immediate (10 mg/kg, IV, IM, and SC) and sustained (8 mg/kg IM, SC) release cephalexin. Pharmacokinetic parameters were calculated by noncompartmenta...περισσότερα »

Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
ABSTRACT Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear cells, such as squamous cell carcinoma, basal cell carcinoma, metastatic renal cell carcinoma, and balloon cell malignant melanoma. These diagnoses can b...περισσότερα »

Clear Cell Atypical Fibroxanthoma: a Case Report and Review of the Literature

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
ABSTRACT Atypical fibroxanthoma (AFX) is a group of cutaneous tumors characterized by a population of fusiform, epithelioid, and pleomorphic cells. Clinically, AFX is commonly found on the head and neck of older adults as a solitary ulcerated nodule. Clear cell atypical fibroxanthoma is a very rare variant of AFX, with only thirteen cases reported to date. The differential diagnoses often include dermal neoplasms composed of clear cells, such as squamous cell carcinoma, basal cell carcinoma, metastatic renal cell carcinoma, and balloon cell malignant melanoma. These diagnoses can b...περισσότερα »

Injury grade is a predictor of aortic-related death among patients with blunt thoracic aortic injury

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Vascular Surgeryfrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SySdWkvia IFTTT

Efficacy of simulation application SimMon for emergency response training

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The American Journal of Emergency Medicinefrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SySbxNvia IFTTT

Knowledge about Hepatitis C Virus Infection and Acceptability of Testing in the 1945–1965 Birth Cohort (Baby Boomers) Presenting to a Large Urban Emergency Department: A Pilot Study

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The Journal of Emergency Medicinefrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QLcofavia IFTTT

Orbital compartment syndrome due to acute hemorrhage within an orbital lymphatic malformation: emergency treatment with percutaneous sclerotherapy

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Vascular and Interventional Radiology from Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SySdFKvia IFTTT

A quick and easy delirium assessment for non-physician research personnel

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The American Journal of Emergency Medicinefrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SySdpovia IFTTT

The impact of transfer on pediatric trauma outcomes

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Journal of Pediatric Surgeryfrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SySb0Dvia IFTTT

Prevalence of marijuana use disorders in the United States between 2001-2001 and 2012-2013

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The Journal of Emergency Medicinefrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QLcnIevia IFTTT

Outcomes of basic versus advanced life support for out-of-hospital medical emergencies

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The Journal of Emergency Medicinefrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SySaKhvia IFTTT

Improved identification of sternal injuries with multi-detector computed tomography (MDCT): sagittal reconstructions

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Clinical Imagingfrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QLcmDZvia IFTTT

Progesterone for traumatic brain injury: a meta-narrative review of randomized controlled trials

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
World Neurosurgeryfrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QLcmDVvia IFTTT

Analgesic adherence in recently discharged trauma patients: An integrative literature review

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Pain Management Nursingfrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SyScBMvia IFTTT

The impact of a preauthorization policy on the after-hours utilization of emergency department computed tomography imaging

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
Academic Radiologyfrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1QLcnrDvia IFTTT

Early trends among seven recommendations from the choosing wisely campaign

Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώρα
The Journal of Emergency Medicinefrom Emergency Medicine via ola Kala on Inoreader http://ift.tt/1SyS9Ggvia IFTTT

Clinical Features and Treatment Modes of Mandibular Fracture at the Department of Oral and Maxillofacial Surgery, Shimane University Hospital, Japan

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background The number of elderly patients with maxillofacial trauma is rapidly increasing due to active lifestyles and longevity. Shimane prefecture has the fastest growing proportion of elderly individuals in Japan. The aim of this study was to reveal the distinctive features and treatment modes of mandibular fracture treatment mode in patients requiring hospitalization at the… Continue reading Clinical Features and Treatment Modes of Mandibular Fracture at the Department of Oral and Maxillofacial Surgery, Shimane University Hospital, Japan

Masthead

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Publication date: April 2016 Source:Translational Research, Volume 170 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UdIwN6 via IFTTT

Editorial Advisory Board

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Publication date: April 2016 Source:Translational Research, Volume 170 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RR0keO via IFTTT

Prevalence of Oral and Maxillofacial Trauma in Elders Admitted to a Reference Hospital in Northeastern Brazil

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Objective To know the prevalence and etiology of oral and maxillofacial trauma in elders. Methods Analytical quantitative cross-sectional study conducted at a public trauma hospital located in Fortaleza-Ceará, Brazil. The study population comprised patients with trauma who were hospitalized from April to August 2014. Of these patients, patients with oral and maxillofacial trauma were chosen… Continue reading Prevalence of Oral and Maxillofacial Trauma in Elders Admitted to a Reference Hospital in Northeastern Brazil

S-Nitrosoglutathione Accelerates Recovery from 5-Fluorouracil-Induced Oral Mucositis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Introduction Mucositis induced by anti-neoplastic drugs is an important, dose-limiting and costly side-effect of cancer therapy. Aim To evaluate the effect of the topical application of S-nitrosoglutathione (GSNO), a nitric oxide donor, on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Materials and Methods Oral mucositis was induced in male hamsters by two intraperitoneal administrations of 5-FU… Continue reading S-Nitrosoglutathione Accelerates Recovery from 5-Fluorouracil-Induced Oral Mucositis

Author Guidelines

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Publication date: April 2016 Source:Translational Research, Volume 170 from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UdIwws via IFTTT

MicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth factor receptor mutations or anaplastic lymphoma kinase translocations

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Publication date: April 2016 Source:Translational Research, Volume 170 Author(s): Sheng-Bin Shi, Meng Wang, Jing Tian, Rui Li, Chun-Xiao Chang, Jie-Lin Qi This study was conducted to evaluate microRNAs (miRNAs) as biomarkers for use in predicting the efficacy of maintenance therapy with pemetrexed in patients with stage IIIb or IV lung adenocarcinoma and who had already… Continue reading MicroRNA 25, microRNA 145, and microRNA 210 as biomarkers for predicting the efficacy of maintenance treatment with pemetrexed in lung adenocarcinoma patients who are negative for epidermal growth f...περισσότερα »

IJERPH, Vol. 13, Pages 306: Global Evidence on the Association between POS Advertising Bans and Youth Smoking Participation

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Point-of-sale (POS) tobacco advertising has been linked to youth smoking susceptibility and experimental smoking. However, there is limited evidence of the association between POS advertising bans and youth smoking participation. This study aims to examine how such bans are associated with current smoking, daily smoking, and regular smoking (≥1 cigarettes per day) participation among… Continue reading IJERPH, Vol. 13, Pages 306: Global Evidence on the Association between POS Advertising Bans and Youth Smoking Participation

Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Publication date: April 2016 Source:Translational Research, Volume 170 Author(s): Elisabeth G.D. Stribos, Theerut Luangmonkong, Anna M. Leliveld, Igle J. de Jong, Willem J. van Son, Jan-Luuk Hillebrands, Marc A. Seelen, Harry van Goor, Peter Olinga, Henricus A.M. Mutsaers Chronic kidney disease is a major health concern, and experimental models bridging the gap between animal studies… Continue reading Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis

ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Background Automated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioactivity and an efficient workflow. For this purpose, we have designed ARAS, an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes with particular… Continue reading ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes

Eye lens dosimetry in anesthesiology: a prospective study

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Abstract The eye lens is one of the most sensitive organs for radiation injury and exposure might lead to radiation induced cataract. Eye lens dosimetry in anesthesiology has been published in few clinical trials and an active debate about the causality of radiation induced cataract is still ongoing. Recently, the International Commission on Radiological Protection (ICRP) recommended a reduction in the annual dose limit for occupational exposure for the lens of the eye from 150 to 20 mSv, averaged over a period of 5 years, with the dose in a single year not exceeding 50 mSv. This ...περισσότερα »

The metabolic vascular syndrome – guide to an individualized treatment

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Abstract In ancient Greek medicine the concept of a distinct syndrome (going together) was used to label 'a group of signs and symptoms' that occur together and 'characterize a particular abnormality and condition'. The (dys)metabolic syndrome is a common cluster of five pre-morbid metabolic-vascular risk factors or diseases associated with increased cardiovascular morbidity, fatty liver disease and risk of cancer. The risk for major complications such as cardiovascular diseases, NASH and some cancers develops along a continuum of risk factors into clinical diseases. Therefore we ...περισσότερα »

SC: Any proof that smoking causes cancer? – Times of India

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
[image: images?q=tbn:ANd9GcQeLFP0NKRrvVgJSeXXwoudqd-459fsLEXFj3ryjVe0NlT1S-RrdgXYEXHyqBPEOzTGAuiw5Rto] The Indian Express *SC: Any proof that smoking causes cancer?**Times of India* And there are people who are smokers yet have lived healthy till the end," the bench said before seeking the Centre's response to the petition filed by an Allahabad-based advocate addicted to 'gutka' and smoking, who is battling *tongue* and mouth *cancer* *…*Decline in tobacco users in India: Healthy sign but smoke signals still worryingThe Indian ExpressSC queries tobacco's *cancer* linkCalcutta Teleg...περισσότερα »

When does chronic migraine strike? A clinical comparison of migraine according to the headache days suffered per month

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
IntroductionAccording to the IHCD-3β classification, chronic migraine (CM) is headache occurring on 15 or more days/month. Episodic migraine (EM) can be divided into low frequency (LFEM) and high frequency (HFEM) depending on the headache days suffered per month.Methods We performed a clinical comparison of migraine characteristics according to monthly headache days suffered. Patients were divided into three groups: LFEM (1–9 headache days/month), HFEM (10–14 headache days/month) and CM (≥15 headache days/month).ResultsThe analysis included 1109 patients. Previously reporte...περισσότερα »

IJERPH, Vol. 13, Pages 302: Meta-Analysis of Cardiac Mortality in Three Cohorts of Carbon Black Production Workers

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
Epidemiological studies have demonstrated associations between airborne environmental particle exposure and cardiac disease and mortality; however, few have examined such effects from poorly soluble particles of low toxicity such as manufactured carbon black (CB) particles in the work place. We combined standardised mortality ratio (SMR) and Cox proportional hazards results from cohort studies of US, UK and German CB production workers. Under a common protocol, we analysed mortality from all causes, heart disease (HD), ischemic heart disease (IHD) and acute myocardial infarction (...περισσότερα »

Nanomaterials, Vol. 6, Pages 46: Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π–π interaction, which have been researched via scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. The rheological experiments showed that the hydrogel materials and drug-loaded hydrogel all demonstrated good mechanical strength and high stability. Further experimental results indica...περισσότερα »

Mitteilungen der GfH

Alexandros SfakianakisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 2 ώρες
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1p7gOWxvia IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 &amp; 00306932607174from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1pwSCNRvia IFTTTfrom #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1pwUAxqvia IFTTT

A call for specific geriatric data on cervical cancers

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
Future Oncology Ahead of Print.from Cancer via ola Kala on Inoreader http://ift.tt/1URWu7Mvia IFTTT

Insight into the molecular basis of Schistosoma haematobium -induced bladder cancer through urine proteomics

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
Abstract Infection due to *Schistosoma haematobium* is carcinogenic. However, the cellular and molecular mechanisms underlying urogenital schistosomiasis (UGS)-induced carcinogenesis have not been well defined. Conceptually, early molecular detection of this phenomenon, through non-invasive procedures, seems feasible and is desirable. Previous analysis of urine collected during UGS suggests that estrogen metabolites, including depurinating adducts, may be useful for this purpose. Here, a new direction was pursued: the identification of molecular pathways and potential biomarkers i...περισσότερα »

High incidence of TERT mutation in brain tumor cell lines

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
Abstract *TERT* promoter gene mutations are highly recurrent in malignant glioma. However, little information exists regarding their presence in experimental brain tumor models. To better characterize systems in which *TERT* mutation studies could be appropriately modeled experimentally, the *TERT* promoter was examined by conventional sequencing in primary brain tumor initiating cells (BTIC), two matched recurrent BTIC lines, a panel of established malignant glioma cell lines, and two meningioma cell lines. Telomerase gene expression was examined by quantitative PCR. We found that...περισσότερα »

Low serum vitamin D is associated with axial length and risk of myopia in young children

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
Abstract The aim of the study was to investigate the relationship between serum 25(OH)D levels and axial length (AL) and myopia in 6-year-old children. A total of 2666 children aged 6 years participating in the birth-cohort study Generation R underwent a stepwise eye examination. First, presenting visual acuity (VA) and AL were performed. Second, automated cycloplegic refraction was measured if LogMAR VA &gt; 0.1. Serum 25-hydroxyvitamin D [25(OH)D] was determined from blood using liquid chromatography/tandem mass spectrometry. Vitamin D related SNPs were determined with a SNP array; ...περισσότερα »

New insights on physical activity and amyotrophic lateral sclerosis

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
from Cancer via ola Kala on Inoreader http://ift.tt/1peQOsUvia IFTTT

Trajectories of body mass index before the diagnosis of cardiovascular disease: a latent class trajectory analysis

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
Abstract Patients with cardiovascular disease (CVD) are a heterogeneous group regarding their body mass index (BMI) levels at the time of diagnosis. To address the heterogeneity of CVD, we examined the trajectories of change in body mass index (BMI) and in other cardio-metabolic risk factors before CVD diagnosis. The study included 6126 participants from the prospective population-based Rotterdam Study, followed over 22 years with clinical examinations every 4 years. Latent class trajectory analysis and mixed-effect models were used to develop trajectories of BMI and other cardio-...περισσότερα »

A call for specific geriatric data on cervical cancers

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
Future Oncology Ahead of Print.from Cancer via ola Kala on Inoreader http://ift.tt/1URWu7Mvia IFTTT

Adjusting to a Diagnosis of Cancer: Processes for Building Patient Capacity for Decision-Making

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες
Abstract This short report contributes to the expanding body of qualitative research literature about the cognitive processes of newly diagnosed cancer patients as they adjust to a diagnosis of cancer. The study is based on secondary qualitative analysis of audio records collected as part of a larger NIH study (RO1D: An Interdisciplinary Perspective: A Social Science Examination of Oncofertility RL1 HD058296). Core categories illustrate the processes of "naming it," "dealing with dealing with it," and finding the "new norm" and were based on nine patient experiences. We observe tha...περισσότερα »

IJERPH, Vol. 13, Pages 306: Global Evidence on the Association between POS Advertising Bans and Youth Smoking Participation

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
Background: Point-of-sale (POS) tobacco advertising has been linked to youth smoking susceptibility and experimental smoking. However, there is limited evidence of the association between POS advertising bans and youth smoking participation. This study aims to examine how such bans are associated with current smoking, daily smoking, and regular smoking (≥1 cigarettes per day) participation among youth. Methods: one to two waves (primarily one wave) of the Global Youth Tobacco Survey were conducted in 130 countries between 2007 and 2011. These surveys were linked to the WHO "MPOWER...περισσότερα »

Energies, Vol. 9, Pages 180: A High-Gain Three-Port Power Converter with Fuel Cell, Battery Sources and Stacked Output for Hybrid Electric Vehicles and DC-Microgrids

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
This paper proposes a novel high-gain three-port power converter with fuel cell (FC), battery sources and stacked output for a hybrid electric vehicle (HEV) connected to a dc-microgrid. In the proposed power converter, the load power can be flexibly distributed between the input sources. Moreover, the charging or discharging of the battery storage device can be controlled effectively using the FC source. The proposed converter has several outputs in series to achieve a high-voltage output, which makes it suitable for interfacing with the HEV and dc-microgrid. On the basis of the ch...περισσότερα »

Molecules, Vol. 21, Pages 324: New Cerebroside and Nucleoside Derivatives from a Red Sea Strain of the Marine Cyanobacterium Moorea producens

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
In the course of our ongoing efforts to identify marine-derived bioactive compounds, the marine cyanobacterium Moorea producens was investigated. The organic extract of the Red Sea cyanobacterium afforded one new cerebroside, mooreaside A (1), two new nucleoside derivatives, 3-acetyl-2′-deoxyuridine (2) and 3-phenylethyl-2′-deoxyuridine (3), along with the previously reported compounds thymidine (4) and 2,3-dihydroxypropyl heptacosanoate (5). The structures of the compounds were determined by different spectroscopic studies (UV, IR, 1D, 2D NMR, and HRESIMS), as well as comparison ...περισσότερα » 

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