Combined treatment of AOM with antibiotics and a leukotriene antagonist to control inflammation is useful for preventing progression to persistent SOM
The effect of the leukotriene antagonist pranlukast on pediatric acute otitis media via International Journal of Pediatric Otorhinolaryngology Publication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Yoshihisa Nakamura, Yuki Hamajima, Motohiko Suzuki, Shinichi Esaki, Makoto Yokota, Masanori Oshika, Ippei Takagi, Keiko Yasui, Naoya Miyamoto, Kazuko Sugiyama, Meiho Nakayama, Shingo Murakami ObjectiveConventional treatment for acute otitis media mainly targets bacteria with antibiotics, neglecting to control for mediators of infl...περισσότερα »
The use of a modified abbé island flap to reconstruct primary lip defects of over 80 %
The use of a modified abbé island flap to reconstruct primary lip defects of over 80 %: Abstract BackgroundLip reconstruction for defects greater than 80 % present a challenge in maintaining acceptable oral function and good aesthetic results. Abbé flaps offer an excellent reconstructive option but are limited to defects under 65 %. MethodsWe describe a two-stage “modified Abbé island flap” technique whereby a full-thickness myocutaneous flap is combined with a modified Karapandzic flap, allowing for reconstruction of total and near total lip defects. ResultsSix patients u... περισσότερα »
The use of a modified abbé island flap to reconstruct primary lip defects of over 80 %
The use of a modified abbé island flap to reconstruct primary lip defects of over 80 %: Lip reconstruction for defects greater than 80 % present a challenge in maintaining acceptable oral function and good aesthetic results. Abbé flaps offer an excellent reconstructive option but are limited to ... Abstract Background *Lip reconstruction for defects greater than 80 % present a challenge in maintaining acceptable oral function and good aesthetic results. Abbé flaps offer an excellent reconstructive option but are limited to defects under 65 %.* Methods *We describe a two-stage “... περισσότερα »
Induction chemotherapy for head and neck squamous cell carcinoma
Induction chemotherapy for head and neck squamous cell carcinoma: A population-based study [1] and two meta-analyses [2,3] have recently addressed the controversial topic of induction chemotherapy (IC) before concurrent chemoradiotherapy (CRT) versus CRT alone for locally advanced head and neck squamous cell carcinoma.
Vestibular hyporeflexia and Ménière's disease : Combined ocular and cervical vestibular evoked myogenic potential
Combined ocular and cervical vestibular evoked myogenic potential in individuals with vestibular hyporeflexia and in patients with Ménière's disease via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 31 May 2016 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Tatiana Rocha Silva, Luciana Macedo de Resende, Marco Aurélio Rocha Santos IntroductionThe vestibular evoked myogenic potential (VEMP) is a potential of mean latency that measures the muscle response to auditory stimulation. This potential can be generated from ... περισσότερα »
Head and neck spindle cell and sclerosing rhabdomyosarcoma
Clinical and molecular heterogeneity of head and neck spindle cell and sclerosing rhabdomyosarcoma: [image: gr1.sml] Spindle cell and sclerosing rhabdomyosarcoma (sRMS/scRMS) accounting for 5–10% of all RMS, were recently reclassified as a stand-alone pathologic entity in the latest WHO classification of soft tissue tumors [1]. Spindle cell RMS was first described by the German–Italian Cooperative Sarcoma Study on the basis of its distinct clinicopathologic features and favorable outcome, resulting in separation from the more common embryonal RMS (ERMS) [2]. Sclerosing RMS was ... περισσότερα »
Trauma care and amputations
Double amputation can't stop paramedic quest: Minutes after waking up from a medically induced coma Noah Filer asked his girlfriend Jenni two important questions. His first question to Jenni, now his wife, was, "Where in the hell are my arm and leg?" He says he took a minute to process the loss of his arm and leg and then asked his second question, "What about my paramedic?" Four weeks earlier, April 1, 2012, Filer had been in a serious motorcycle collision that resulted in a traumatic brain injury and the loss of his left arm and left leg. *Eager to learn* Filer, now 27 and li... περισσότερα »
Ménière's Disease
Exploring Methods to Measure the Prevalence of Ménière's Disease in the US Clinformatics™ Database, 2010-2012: Recent studies on the epidemiology of the inner-ear disorder Ménière's disease (MD) use disparate methods for sample selection, case identification and length of observation. Prevalence estimates vary geographically from 17 to 513 cases per 100,000 people. We explored the impact of case detection strategies and observation periods in estimating the prevalence of MD in the USA, using data from a large insurance claims database. Using case detection strategies of ≥1, ≥2 and ≥3...περισσότερα »
Paediatric Cochlear Implantation in Patients with Waardenburg Syndrome
Paediatric Cochlear Implantation in Patients with Waardenburg Syndrome: *Objective:* To analyse the benefit of cochlear implantation in young deaf children with Waardenburg syndrome (WS) compared to a reference group of young deaf children without additional disabilities. *Method:* A retrospective study was conducted on children with WS who underwent cochlear implantation at the age of 2 years or younger. The post-operative results for speech perception (phonetically balanced standard Dutch consonant-vocal-consonant word lists) and language comprehension (the Reynell Developmental L...περισσότερα »
Psychoacoustic and auditory brainstem response thresholds
In-air hearing of a diving duck: A comparison of psychoacoustic and auditory brainstem response thresholds: [image: cm_sbs_024_plain.png] Auditory sensitivity was measured in a species of diving duck that is not often kept in captivity, the lesser scaup. Behavioral (psychoacoustics) and electrophysiological [the auditory brainstem response (ABR)] methods were used to measure in-air auditory sensitivity, and the resulting audiograms were compared. Both approaches yielded audiograms with similar U-shapes and regions of greatest sensitivity (2000−3000 Hz). However, ABR thresholds wer... περισσότερα »
Electrode-induced trauma: localized therapeutic hypothermia conserves residual hearing
A cool approach to reducing electrode-induced trauma: localized therapeutic hypothermia conserves residual hearing in cochlear implantation via Hearing Research Publication date: Available online 31 May 2016 *Source:*Hearing Research Author(s): Ilmar Tamames, Curtis King, Esperanza Bas, W. Dalton Dietrich, Fred Telischi, Suhrud M. Rajguru ObjectiveThe trauma caused during cochlear implant insertion can lead to cell death and a loss of residual hair cells in the cochlea. Various therapeutic approaches have been studied to prevent cochlear implant-induced residual hearing loss with lim...περισσότερα »
Impact of peripheral hearing loss on top-down auditory processing
Impact of peripheral hearing loss on top-down auditory processing via Hearing Research Publication date: Available online 31 May 2016 *Source:*Hearing Research Author(s): Alexandria M.H. Lesicko, Daniel A. Llano The auditory system consists of an intricate set of connections interposed between hierarchically arranged nuclei. The ascending pathways carrying sound information from the cochlea to the auditory cortex are, predictably, altered in instances of hearing loss resulting from blockage or damage to peripheral auditory structures. However, hearing loss-induced changes in descend... περισσότερα »
Speech Perception in Classroom Acoustics
by Children With Cochlear Implants and With Typical Hearing: Purpose This study measured speech perception ability in children with cochlear implants and children with typical hearing when listening across ranges of reverberation times (RTs) and speech-to-noise ratios. Method Participants listened in classroom RTs of 0.3, 0.6, and 0.9 s combined with a 21-dB range of speech-to-noise ratios. Subsets also listened in a low-reverberant audiological sound booth. Performance measures using the Bamford-Kowal-Bench Speech-in-Noise Test (Etymotic Research, Inc., 2005) were 50% correct wo... περισσότερα »
Lidocaine Tinnitus
Lidocaine Tinnitus: In the United States, up to 35 percent of adults will experience an episode of tinnitus. Although most cases of tinnitus are temporary, chronic tinnitus can be incapacitating, making it difficult for you to function and hear the sounds that you want to hear. If you suffer from worsening volume of tinnitus, lidocaine tinnitus may be a solution for you. Who Qualifies for Lidocaine Tinnitus? Lidocaine is a way to treat chronic tinnitus that has been worsening over a period of 4 to 8 weeks or longer. Lidocaine would not be used to treat temporary tinnitus. About 8 ... περισσότερα »
Allergy and Immunology
4h Lipopolysaccharide-Induced CD300b Receptor Binding to Toll-like Receptor 4 Alters Signaling to Drive Cytokine Responses that Enhance Septic Shock Publication date: Available online 31 May 2016Source:Immunity Author(s): Oliver H. Voss, Yousuke Murakami, Mirna Y. Pena, Ha-Na Lee, Linjie Tian, David H. Margulies, Jonathan M. Street, Peter S.T. Yuen, Chen-Feng Qi, Konrad Krzewski, John E. ColiganReceptor CD300b is implicated... 4h Store-Operated Ca2+ Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity Publication date: Available online 31 May 2016Source:... περισσότερα »
Cancer
now Obesity promotes desmoplasia in PDAC [Research Articles] It remains unclear how obesity worsens treatment outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). In normal pancreas, obesity promotes inflammation and fibrosis. We found in mouse models of PDAC that obesity also promotes desmoplasia associated with accelerated tumor growth and impaired... now People with dementia: what is known about their experience of cancer treatment and cancer treatment outcomes? A systematic review. Abstract ObjectiveTo report a systematic review of what is currently known about... περισσότερα »
Melanoma
8h A combined approach to treating metastatic melanoma A combined approach to treating metastatic melanoma: Oncologists at the Fred Hutchinson Cancer Research Center have successfully treated a patient with metastatic melanoma by combining two different types of immunotherapy. from Melanoma via ola Kala on Inoreader via IFTTT 8h A combined approach to treating metastatic melanoma A combined approach to treating metastatic melanoma: Oncologists at the Fred Hutchinson Cancer Research Center have successfully treated a patient with metastatic melanoma by combining two different type... περισσότερα »
Squamous cell carcinomas
34m Recommendations for the implementation of BRCA testing in the care and treatment pathways of ovarian cancer patients Recommendations for the implementation of BRCA testing in the care and treatment pathways of ovarian cancer patients: Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader via IFTTT 1h Association of endothelial proliferation with the magnitude of weight loss during calorie restriction Association of endothelial proliferation with the magnitude of weight loss during calorie restriction: Abstract Objectives Substantial weight loss through intens...περισσότερα »
OtoRhinoLaryngology
3h Lidocaine Tinnitus In the United States, up to 35 percent of adults will experience an episode of tinnitus. Although most cases of tinnitus are temporary, chronic tinnitus can be incapacitating, making it difficult for you to function and hear the sounds that you want to hear. If you suffer from worsening volume of tinnitus,... 3h Trending Articles in AJA from #Audiology via xlomafota13 on Inoreader http://ift.tt/1WXC3IL via IFTTT 3h Speech Perception in Classroom Acoustics by Children With Cochlear Implants and With Typical Hearing Purpose This study measured speech percept... περισσότερα »
Modified tragus edge approach for mid-level or low condylar fractures
The aim of this study was to evaluate and report a modified tragus edge approach (MTEA) for surgical access to mid-level or low condylar fractures. The MTEA was used on 45 patients (59 sides). All of the patients were reviewed for scarring, parotid fistula, facial nerve function, occlusion, deviation, and limitation of mouth opening (MO). Forty-one patients (64 sides) with middle or low level condylar fractures who underwent surgery by retromandibular approach during the same period were selected for comparison. http://ift.tt/1RKpWGY
Induction chemotherapy for head and neck squamous cell carcinoma
A population-based study [1] and two meta-analyses [2,3] have recently addressed the controversial topic of induction chemotherapy (IC) before concurrent chemoradiotherapy (CRT) versus CRT alone for locally advanced head and neck squamous cell carcinoma. http://ift.tt/1XcU0np
FOXP3+ CD4 T-cell maturity and responses to microbial stimulation alter with age and associate with early life gut colonization
Peripheral CD4+FOXP3+ T-cells from children are immature and less responsive to S. aureus. Early gut colonization with S. aureus and lactobacilli associates with the functional phenotype of FOXP3+ cells, implying involvement of microbes in immune-maturation. http://ift.tt/1XNjYwd
A statistical shape modelling framework to extract 3D shape biomarkers from medical imaging data: assessing arch morphology of repaired coarctation of the aorta
AbstractBackground Medical image analysis in clinical practice is commonly carried out on 2D image data, without fully exploiting the detailed 3D anatomical information that is provided by modern non-invasive medical imaging techniques. In this paper, a statistical shape analysis method is presented, which enables the extraction of 3D anatomical shape features from cardiovascular magnetic resonance (CMR) image data, with no need for manual landmarking. The method was applied to repaired aortic coarctation arches that present complex shapes, with the aim of capturing shape features a...περισσότερα »
Impact of an endorectal coil for 1H-magnetic resonance spectroscopy of the prostate at 3.0T in comparison to 1.5T: Do we need an endorectal coil?
Publication date: Available online 31 May 2016 *Source:*European Journal of Radiology Author(s): Maximilian K.M. Hoffner, Frank Huebner, Jan Erik Scholtz, Stephan Zangos, Boris Schulz, Wolfgang Luboldt, Thomas J. Vogl, Boris Bodelle ObjectivesTo evaluate the influence of endorectal coil (ERC) regarding spectral quality and diagnostic suitability and diagnostic performance in 3.0T 1H-magnetic resonance spectroscopy imaging (MRSI) compared to 1.5T MRSI.Materials and methodsThe study was approved by the Institutional Review Board. MRSI of the prostate was performed on 19 patients at 1.5T... περισσότερα »
Coronectomy of mandibular teeth other than third molars: a case series
Coronectomy is gaining popularity for the management of mandibular third molars that pose a risk of injury to the inferior dental nerve, as it considerably reduces the risk when compared with extraction. The technique could also be beneficial to other teeth. We report 17 patients who had coronectomy of mandibular teeth that were not third molars. Clinical and radiographic follow up for a median (range) of 12 (1-79) months showed satisfactory healing and no transient or permanent injury to the nerve. http://ift.tt/1Vtv7C4
Botulinum toxin used to treat recurrent dislocation of the temporomandibular joint in a patient with osteoporosis
Recurrent dislocations of the temporomandibular joint (TMJ) can be debilitating. We describe a patient with osteoporosis who presented to our regional centre where we have limited resources. We injected botulinum toxin into both of her lateral pterygoid muscles, and six months later she has not required further injections and has had no issues with tolerance of the procedure. Botulinum toxin is a safe, conservative approach to recurrent dislocations of the TMJ and can be given accurately by an experienced surgeon without the use of an electromyogram. http://ift.tt/1TIn6o6
Third molar consent forms: how comprehensive should they be?
To establish a gold standard for the information given to patients about the risks associated with third molar extractions, we surveyed 79 oral and maxillofacial surgeons (OMFS) to find out what information they gave to patients during the consent process. We also surveyed 62 medicolegal solicitors to find out what information they thought patients should be given before the procedure, and in what form. A total of 20/76 OMFS (26%) used a two-stage process to obtain consent; 13 (17%) included paraesthesia on the consent form and also gave out an information leaflet. http://ift.tt/1Vt... περισσότερα »
Health-related quality of life after treatment for neoplasia of the major salivary glands: a pilot study
Treatment of malignancy of the salivary glands risks damage to the cranial nerves, and clinicians’ traditional view has been that this will result in adverse effects on physical function and subsequent health-related quality of life (QoL). Preservation of nerves has been advocated to lessen this impact, but we know of no evidence that sacrifice of the facial nerve has any effect on subsequent QoL. We collected data prospectively before and after operation for all malignancies of the major salivary glands treated over five years using two health-related QoL questionnaires: the Univers... περισσότερα »
The use of a modified abbé island flap to reconstruct primary lip defects of over 80 %
Lip reconstruction for defects greater than 80 % present a challenge in maintaining acceptable oral function and good aesthetic results. Abbé flaps offer an excellent reconstructive option but are limited to d... http://ift.tt/1TIltXt
Communication Considerations for Children With Hearing Loss
When a child fails a hearing screening and follow-up testing reveals a hearing loss, parents often experience a roller coaster of emotions. During this time, parents might get overwhelmed by making decisions that will affect the rest of their child’s life. However, as professionals, we must convey the importance of early intervention on future outcomes. Early exposure to language, in any form, lays the foundation for future communication skills. We also must come to the table with unbiased information. Allow parents to review all options and choose a path to communication they feel ... περισσότερα »
Ilko Dacowo: The practice of iatrogenic tooth enucleation
Publication date: Available online 31 May 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): A.J. Holder http://ift.tt/1P1QAeK
Botulinum toxin used to treat recurrent dislocation of the temporomandibular joint in a patient with osteoporosis
Publication date: Available online 30 May 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Mehmet Oztel, Wojciech M. Bilski, Arthur Bilski Recurrent dislocations of the temporomandibular joint (TMJ) can be debilitating. We describe a patient with osteoporosis who presented to our regional centre where we have limited resources. We injected botulinum toxin into both of her lateral pterygoid muscles, and six months later she has not required further injections and has had no issues with tolerance of the procedure. Botulinum toxin is a safe, conservative approach... περισσότερα »
Guerin sign in midfacial fractures
Publication date: Available online 31 May 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Irfan ul Hassan Haji, Surinder Pal Singh Sodhi, Badr Bin Abdulrahman Al-Jandan, Mohamed Jaber We report a patient with multiple fractures of the midface and Guerin sign bilaterally after maxillofacial trauma. To the best of our knowledge, this is the first time that this rare presentation of Guerin sign has been published. http://ift.tt/1P1QEuQ
Third molar consent forms: how comprehensive should they be?
Publication date: Available online 30 May 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Danielle Britton, Andrew Burns, Stephen Hudyba, Michael Nugent To establish a gold standard for the information given to patients about the risks associated with third molar extractions, we surveyed 79 oral and maxillofacial surgeons (OMFS) to find out what information they gave to patients during the consent process. We also surveyed 62 medicolegal solicitors to find out what information they thought patients should be given before the procedure, and in what form. A tot... περισσότερα »
Bone carrier technique with disposable syringe
Publication date: Available online 31 May 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Takaaki Ogawa, Kenichi Kurita, Takao Imai, Minoru Miyake http://ift.tt/1P1QC6j
Health-related quality of life after treatment for neoplasia of the major salivary glands: a pilot study
Publication date: Available online 30 May 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): J. Breeze, A. Morrison, D. Dawson, J. Tipper, K. Rehman, N. Grew, N. Pigadas Treatment of malignancy of the salivary glands risks damage to the cranial nerves, and clinicians’ traditional view has been that this will result in adverse effects on physical function and subsequent health-related quality of life (QoL). Preservation of nerves has been advocated to lessen this impact, but we know of no evidence that sacrifice of the facial nerve has any effect on subsequent Q... περισσότερα »
Coronectomy of mandibular teeth other than third molars: a case series
Publication date: Available online 30 May 2016 *Source:*British Journal of Oral and Maxillofacial Surgery Author(s): Meera Samani, Marianne Henien, Christopher Sproat Coronectomy is gaining popularity for the management of mandibular third molars that pose a risk of injury to the inferior dental nerve, as it considerably reduces the risk when compared with extraction. The technique could also be beneficial to other teeth. We report 17 patients who had coronectomy of mandibular teeth that were not third molars. Clinical and radiographic follow up for a median (range) of 12 (1-79) months... περισσότερα »
Is the Levels of Processing effect language-limited?
Publication date: February 2017 Source:Journal of Memory and Language, Volume 92 Author(s): Alan D. Baddeley, Graham J. Hitch The concept of Levels of Processing (LOP), proposing that deep coding enhances retention, has played a central role in the study of episodic memory. Evidence has however been based almost entirely on retention of individual words. Across five experiments, we compare LOP effects between visual and verbal stimuli, using judgments of pleasantness as a method of inducing deep encoding and a range of shallow encoding judgments selected so as to be applicable to bot...περισσότερα »
Induction chemotherapy for head and neck squamous cell carcinoma
Publication date: Available online 30 May 2016 *Source:*Oral Oncology Author(s): James T. Parsons, Bruce D. Greene http://ift.tt/1UfsP49
Clinical and molecular heterogeneity of head and neck spindle cell and sclerosing rhabdomyosarcoma
Publication date: Available online 31 May 2016 *Source:*Oral Oncology Author(s): Adepitan A. Owosho, Sonja Chen, Shruti Kashikar, Lei Zhang, Chun-Liang Chen, Leonard H. Wexler, Cherry L. Estilo, Joseph M. Huryn, Cristina R. Antonescu http://ift.tt/24hQVB5
Impact of peripheral hearing loss on top-down auditory processing
[image: S03785955.gif] Publication date: Available online 31 May 2016 *Source:*Hearing Research Author(s): Alexandria M.H. Lesicko, Daniel A. Llano The auditory system consists of an intricate set of connections interposed between hierarchically arranged nuclei. The ascending pathways carrying sound information from the cochlea to the auditory cortex are, predictably, altered in instances of hearing loss resulting from blockage or damage to peripheral auditory structures. However, hearing loss-induced changes in descending connections that emanate from higher auditory centers and pr...περισσότερα »
A cool approach to reducing electrode-induced trauma: localized therapeutic hypothermia conserves residual hearing in cochlear implantation
[image: alertIcon.gif] Publication date: Available online 31 May 2016 *Source:*Hearing Research Author(s): Ilmar Tamames, Curtis King, Esperanza Bas, W. Dalton Dietrich, Fred Telischi, Suhrud M. Rajguru ObjectiveThe trauma caused during cochlear implant insertion can lead to cell death and a loss of residual hair cells in the cochlea. Various therapeutic approaches have been studied to prevent cochlear implant-induced residual hearing loss with limited success. In the present study, we show the efficacy of mild to moderate therapeutic hypothermia of 4 to 6ºC applied to the cochlea i... περισσότερα »
Is heat pain detection threshold associated with the area of secondary hyperalgesia following brief thermal sensitization? A study of healthy volunteers - design and detailed plan of analysis
AbstractBackground Several factors are believed to influence the development and experience of pain. Human clinical pain models are central tools, in the investigation of basic physiologic pain responses, and can be applied in patients as well as in healthy volunteers. Each clinical pain model investigates different aspects of the human pain response. Brief thermal sensitization induces a mild burn injury, resulting in development of primary hyperalgesia at the site of stimulation, and secondary hyperalgesia surrounding the site of stimulation. Central sensitization is believed to... περισσότερα »
Feeding Behavior of Subadult Sixgill Sharks (Hexanchus griseus) at a Bait Station
by Bryan McNeil, Dayv Lowry, Shawn Larson, Denise Griffing This is the first in-situ study of feeding behaviors exhibited by bluntnose sixgill sharks. Bait was placed beneath the Seattle Aquarium pier situated on the waterfront in Elliott Bay, Puget Sound, Washington at 20m of water depth. Cameras and lights were placed around the bait box to record sixgill shark presence and behavior while feeding. Analysis of feeding behavior revealed that sixgills utilize a bite comparable to many other elasmobranchs and aquatic vertebrates, have the ability to protrude their upper jaw, change t... περισσότερα »
Nagpur oral cancer capital of the world - Times of India
*Nagpur oral cancer capital of the world* *Times of India* Diseases caused by tobacco include Buccal mucosa at first position followed by tongue, *larynx*, hypopharynx, oropharynx and floor *of* mouth *cancers*. Tobacco Consumers in Maharashtra. In Maharashtra 31.4% (2,58,99,273) people consume tobacco out *of* ... *and more »* http://ift.tt/1ZaYCaS
CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease
by Shunsuke Sakai, Keith D. Kauffman, Michelle A. Sallin, Arlene H. Sharpe, Howard A. Young, Vitaly V. Ganusov, Daniel L. Barber IFN-γ–producing CD4 T cells are required for protection against *Mycobacterium tuberculosis* (Mtb) infection, but the extent to which IFN-γ contributes to overall CD4 T cell-mediated protection remains unclear. Furthermore, it is not known if increasing IFN-γ production by CD4 T cells is desirable in Mtb infection. Here we show that IFN-γ accounts for only ~30% of CD4 T cell-dependent cumulative bacterial control in the lungs over the first six weeks of i... περισσότερα »
The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration
by Nina Wallaschek, Anirban Sanyal, Fabian Pirzer, Annie Gravel, Yasuko Mori, Louis Flamand, Benedikt B. Kaufer Human herpesvirus 6A (HHV-6A) and 6B (HHV-6B) are ubiquitous betaherpesviruses that infects humans within the first years of life and establishes latency in various cell types. Both viruses can integrate their genomes into telomeres of host chromosomes in latently infected cells. The molecular mechanism of viral integration remains elusive. Intriguingly, HHV-6A, HHV-6B and several other herpesviruses harbor arrays of telomeric repeats (TMR) identical to human telomere seq... περισσότερα »
The Course of Pain Intensity in Patients Undergoing Herniated Disc Surgery: A 5-Year Longitudinal Observational Study
by Marie Dorow, Margrit Löbner, Janine Stein, Alexander Pabst, Alexander Konnopka, Hans J. Meisel, Lutz Günther, Jürgen Meixensberger, Katarina Stengler, Hans-Helmut König, Steffi G. Riedel-Heller Objectives The aims of this study are to answer the following questions (1) How does the pain intensity of lumbar and cervical disc surgery patients change within a postoperative time frame of 5 years? (2) Which sociodemographic, medical, work-related, and psychological factors are associated with postoperative pain in lumbar and cervical disc surgery patients? Methods The baseline sur... περισσότερα »
Role of Ultraviolet Radiation in Papillomavirus-Induced Disease
by Aayushi Uberoi, Satoshi Yoshida, Ian H. Frazer, Henry C. Pitot, Paul F. Lambert Human papillomaviruses are causally associated with 5% of human cancers. The recent discovery of a papillomavirus (MmuPV1) that infects laboratory mice provides unique opportunities to study the life cycle and pathogenesis of papillomaviruses in the context of a genetically manipulatable host organism. To date, MmuPV1-induced disease has been found largely to be restricted to severely immunodeficient strains of mice. In this study, we report that ultraviolet radiation (UVR), specifically UVB spectra,...περισσότερα »
HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization
by Qiang Chen, Jun-Jie Bei, Chuan Liu, Shi-Bin Feng, Wei-Bo Zhao, Zhou Zhou, Zheng-Ping Yu, Xiao-Jun Du, Hou-Yuan Hu Numerous clinical conditions have been linked to ectopic mineralization (EM). This process of pathological biomineralization is complex and not fully elucidated, but thought to be started within matrix vesicles (MVs). We hypothesized that high mobility group box 1 (HMGB1), a cytokine associated with biomineralizing process under physiological and pathological conditions, induces EM via promoting MVs secretion from macrophages. In this study, we found that HMGB1 signi...περισσότερα »
Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells
by Joselli Silva-O’Hare, Isabela Silva de Oliveira, Thaís Klevorn, Valter A. Almeida, Geraldo G. S. Oliveira, Ajax M. Atta, Luiz Antonio R. de Freitas, Washington L. C. dos-Santos Visceral leishmaniasis (VL) is a disease caused by *Leishmania infantum*, which is transmitted by phlebotomine sandflies. Dogs are the main urban reservoir of this parasite and the disease presents similar characteristics in both humans and dogs. In this paper, we investigated the potential pathways involved in plasma cell replacement of normal cell populations in the spleen, with respect to disease sever... περισσότερα »
Characterization and Transferable Utility of Microsatellite Markers in the Wild and Cultivated Arachis Species
by Li Huang, Bei Wu, Jiaojiao Zhao, Haitao Li, Weigang Chen, Yanli Zheng, Xiaoping Ren, Yuning Chen, Xiaojing Zhou, Yong Lei, Boshou Liao, Huifang Jiang Microsatellite or simple sequence repeat (SSR) is one of the most widely distributed molecular markers that have been widely utilized to assess genetic diversity and genetic mapping for important traits in plants. However, the understanding of microsatellite characteristics in *Arachis* species and the currently available amount of high-quality SSR markers remain limited. In this study, we identified 16,435 genome survey sequences ... περισσότερα »
Feeding Behavior of Subadult Sixgill Sharks (Hexanchus griseus) at a Bait Station
by Bryan McNeil, Dayv Lowry, Shawn Larson, Denise Griffing This is the first in-situ study of feeding behaviors exhibited by bluntnose sixgill sharks. Bait was placed beneath the Seattle Aquarium pier situated on the waterfront in Elliott Bay, Puget Sound, Washington at 20m of water depth. Cameras and lights were placed around the bait box to record sixgill shark presence and behavior while feeding. Analysis of feeding behavior revealed that sixgills utilize a bite comparable to many other elasmobranchs and aquatic vertebrates, have the ability to protrude their upper jaw, change t... περισσότερα »
Isotopic Evidence of a Wide Spectrum of Feeding Strategies in Southern Hemisphere Humpback Whale Baleen Records
by Pascale Eisenmann, Brian Fry, Carly Holyoake, Douglas Coughran, Steve Nicol, Susan Bengtson Nash Our current understanding of Southern hemisphere humpback whale (*Megaptera novaeangliae*) ecology assumes high-fidelity feeding on Antarctic krill in Antarctic waters during summer, followed by fasting during their annual migration to and from equatorial breeding grounds. An increase in the number of reported departures from this feeding/fasting model suggests that the current model may be oversimplified or, alternatively, undergoing contemporary change. Information about the feedin...περισσότερα »
Novel Detection of Coxiella spp., Theileria luwenshuni, and T. ovis Endosymbionts in Deer Keds (Lipoptena fortisetosa)
by Seung-Hun Lee, Kyoo-Tae Kim, Oh-Deog Kwon, Younsung Ock, Taeil Kim, Donghag Choi, Dongmi Kwak We describe for the first time the detection of *Coxiella*-like bacteria (CLB), *Theileria luwenshuni*, and *T*. *ovis* endosymbionts in blood-sucking deer keds. Eight deer keds attached to a Korean water deer were identified as *Lipoptena fortisetosa* (Diptera: Hippoboscidae) by morphological and genetic analyses. Among the endosymbionts assessed, CLB, *Theileria luwenshuni*, and *T*. *ovis* were identified in *L*. *fortisetosa* by PCR and nucleotide sequencing. Based on phylogeny, CLB... περισσότερα »
Computational Identification of Novel Stage-Specific Biomarkers in Colorectal Cancer Progression
by Ashok Palaniappan, Karthick Ramar, Satish Ramalingam It is well-known that the conversion of normal colon epithelium to adenoma and then to carcinoma stems from acquired molecular changes in the genome. The genetic basis of colorectal cancer has been elucidated to a certain extent, and much remains to be known about the identity of specific cancer genes that are associated with the advancement of colorectal cancer from one stage to the next. Here in this study we attempted to identify novel cancer genes that could underlie the stage-specific progression and metastasis of colorec... περισσότερα »
Chronic Iron Overload Results in Impaired Bacterial Killing of THP-1 Derived Macrophage through the Inhibition of Lysosomal Acidification
by Jun-Kai Kao, Shih-Chung Wang, Li-Wei Ho, Shi-Wei Huang, Shu-Hao Chang, Rei-Cheng Yang, Yu-Yuan Ke, Chun-Ying Wu, Jiu-Yao Wang, Jeng-Jer Shieh Iron is essential for living organisms and the disturbance of iron homeostasis is associated with altered immune function. Additionally, bacterial infections can cause major complications in instances of chronic iron overload, such as patients with transfusion-dependent thalassemia. Monocytes and macrophages play important roles in maintaining systemic iron homoeostasis and in defense against invading pathogens. However, the effect of iron... περισσότερα »
Effect of Surface Modifications of Ti40Zr10Cu38Pd12 Bulk Metallic Glass and Ti-6Al-4V Alloy on Human Osteoblasts In Vitro Biocompatibility
by Andreu Blanquer, Anna Hynowska, Carme Nogués, Elena Ibáñez, Jordi Sort, Maria Dolors Baró, Berna Özkale, Salvador Pané, Eva Pellicer, Leonardo Barrios The use of biocompatible materials, including bulk metallic glasses (BMGs), for tissue regeneration and transplantation is increasing. The good mechanical and corrosion properties of Ti40Zr10Cu38Pd12 BMG and its previously described biocompatibility makes it a potential candidate for medical applications. However, it is known that surface properties like topography might play an important role in regulating cell adhesion, prolife... περισσότερα »
Detection and Genotyping of Coxiella burnetii and Coxiella-Like Bacteria in Horses in South Korea
by Min-Goo Seo, Seung-Hun Lee, Dorene VanBik, In-Ohk Ouh, Sun-Hee Yun, Eunsang Choi, Yong-Soo Park, Sang-Eun Lee, Jong Wan Kim, Gil-Jae Cho, Oh-Deog Kwon, Dongmi Kwak *Coxiella burnetii* and *Coxiella*-like bacteria (CLB) are genetically and ecologically distinct despite some genetic similarities. Furthermore, CLB are exceptionally diverse and widespread in ticks, but rarely detected in domestic animals. Since *Coxiella* bacteria can be transmitted from infected horses by inhalation or by coming in contact with ticks during activities such as horseback riding, it is necessary to st...περισσότερα »
Antioxidant Activities of 4-Methylumbelliferone Derivatives
by Yasameen K. Al-Majedy, Ahmed A. Al-Amiery, Abdul Amir H. Kadhum, Abu Bakar Mohamad The synthesis of derivatives of 4-Methylumbelliferone (4-MUs), which are structurally interesting antioxidants, was performed in this study. The modification of 4-Methylumbelliferone (4-MU) by different reaction steps was performed to yield the target compounds, the 4-MUs. The 4-MUs were characterized by different spectroscopic techniques (Fourier transform infrared; FT-IR and Nuclear magnetic resonance; NMR) and micro-elemental analysis (CHNS). The in vitro antioxidant activity of the 4-MUs was ... περισσότερα »
Development of a vestibular schwannoma xenograft zebrafish model for in vivo antitumor drug screening
ConclusionOur in vivo model has the potential to greatly facilitate vestibular schwannoma treatment because of its speed, simplicity, reproducibility, and amenability to live imaging. Level of EvidenceN/A. Laryngoscope, 2016 (Source: The Laryngoscope) http://ift.tt/1RJoiWa
Liver disease in patients undergoing head and neck surgery: Incidence and risk for postoperative complications
ConclusionThere is a high risk to detect liver disease in patients undergoing head and neck surgery of the aerodigestive tract. Those with advanced liver disease are at high risk for perioperative mortality, and this risk should be judiciously considered in medical/surgical decision making and postoperative care. Level of Evidence2c. Laryngoscope, 2016 (Source: The Laryngoscope) http://ift.tt/1PgboEN
Safety of transoral surgery for oropharyngeal malignancies: An analysis of the ACS NSQIP
ConclusionTransoral resection of properly selected oropharyngeal tumors is safe, with low 30‐day morbidity and mortality. A greater understanding of the risk factors for complications following transoral surgery may improve patient selection and safety. Level of Evidence4. Laryngoscope, 2016 (Source: The Laryngoscope) http://ift.tt/1RJosgb
Vocal fold motion outcome based on excellent prognosis with laryngeal electromyography
ConclusionNearly 80% of patients determined to have excellent prognosis for vocal fold motion recovery experienced return of vocal fold motion. This information will help clinicians not only counsel their patients on expectations but will also help guide treatment. Level of Evidence4. Laryngoscope, 2016 (Source: The Laryngoscope) http://ift.tt/1Pgamsq
A target field design of open multi-purpose RF coil for musculoskeletal MR imaging at 3T
[image: S0730725X.gif] Publication date: October 2016 *Source:*Magnetic Resonance Imaging, Volume 34, Issue 8 Author(s): Fei Gao, Rui Zhang, Diange Zhou, Xiaoying Wang, Kefu Huang, Jue Zhang Musculoskeletal MR imaging under multi-angle situations plays an increasingly important role in assessing joint and muscle tissues system. However, there are still limitations due to the closed structures of most conventional RF coils. In this study, a time-harmonic target-field method was employed to design open multi-purpose coil (OMC) for multi-angle musculoskeletal MR imaging. The phantom im...περισσότερα »
Comparison of actual with default hematocrit value in dynamic contrast enhanced MR perfusion quantification in grading of human glioma
[image: S0730725X.gif] Publication date: October 2016 *Source:*Magnetic Resonance Imaging, Volume 34, Issue 8 Author(s): Prativa Sahoo, Pradeep K. Gupta, Rana Patir, Sandeep Vaishya, Indrajit Saha, Rakesh K. Gupta PurposeDynamic contrast enhanced (DCE) MRI is used to grade and to monitor the progression of glioma while on treatment. Usually, a fixed hematocrit (Hct) value for adults is assumed to be ~45%; however, it is actually known for individual variations. Purpose of this study was to investigate the effect of measured Hct values in glioma grading using DCE-MRI.Materials and me... περισσότερα »
Self-reported gadolinium toxicity: A survey of patients with chronic symptoms
[image: alertIcon.gif] Publication date: October 2016 *Source:*Magnetic Resonance Imaging, Volume 34, Issue 8 Author(s): Lauren M.B. Burke, Miguel Ramalho, Mamdoh AlObaidy, Emily Chang, Michael Jay, Richard C. Semelka PurposeThis study aims to describe the self-reporting symptoms experienced by individuals with self-reported normal renal function after gadolinium based contrast agent (GBCA) administration.Materials and methodsThis HIPAA-compliant, IRB-approved study consisted of an anonymous online survey of patients who believe that they suffer from gadolinium toxicity. 50 responde...περισσότερα »
Multiparametric MR can identify high grade prostatic intraepithelial neoplasia (HGPIN) lesions and predict future detection of prostate cancer in men with a negative initial prostate biopsy
[image: alertIcon.gif] Publication date: October 2016 *Source:*Magnetic Resonance Imaging, Volume 34, Issue 8 Author(s): Durgesh Kumar Dwivedi, Rajeev Kumar, Girdhar Singh Bora, Sanjay Sharma, Sanjay Thulkar, Siddhartha Datta Gupta, Naranamangalam R. Jagannathan PurposeThis study aims to determine the pre-biopsy diffusion-weighted imaging (DWI) and magnetic resonance spectroscopic imaging (MRSI) characteristics of patients with high-grade prostatic intraepithelial neoplasia (HGPIN) and perform follow-up studies in these patients to assess the clinical implications.Materials and meth...περισσότερα »
Here's how your smoking colleague is killing you - Times of India
Times of India *Here's how your smoking colleague is killing you* *Times of India* The tobacco epidemic is one *of* the biggest public health threats the world has ever faced, killing around 6 million people every year, states WHO. While more than 5 million *of* these deaths are the result *of* direct tobacco uses, more than 6,00,000 *...* One hour to 15 years: What not smoking means for your health and walletHindustan Times Testimonies from regretful smokers coming to television commercialsThe Hankyoreh *all 346 news articles »* http://ift.tt/1O1NBrJ
