Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
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Κυριακή 29 Μαΐου 2016

OtoRhinoLaryngology & Medicine,New Articles,May 29th,2016



Pathways controlling dNTP pools to maintain genome stability

Publication date: Available online 28 May 2016 Source:DNA Repair Author(s): Sean G. Rudd, Nicholas C.K. Valerie, Thomas Helleday Artificially modified nucleotides, in the form of nucleoside analogues, are widely used in the treatment of cancers and various other diseases, and have become important tools in the laboratory to characterise DNA repair pathways. In contrast, the […]

Endoscopic Septoplasty—Two Handed Technique with Endoscope Holder: A Novel Approach

Abstract The popularity of endoscopes has been expanding not only in diagnostics but also in therapeutics. The traditional septal surgery also has come under the purview of endoscopic surgery in the last few decades. Endoscopic septoplasty has definitely many advantages over the conventional procedure. But the only disadvantage of endoscopic surgery is that it is […]

A Short Term Subjective and Objective Analysis of Modified Endoscopic Lothrop’s Procedure and Its Functional Outcome: Our Experience

Abstract To study the short-term functional outcomes of the endoscopic modified Lothrop procedure with well defined subjective and objective criteria. It’s a retrospective cohort study with chart review carried out at a tertiary referral center. 31 patients with chronic frontal sinusitis who underwent endoscopic modified Lothrop’s procedure with uncinate preservation during the period Jan 2011–2014 […]

The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

Publication date: July 2016 Source:Molecular Immunology, Volume 75 Author(s): Su Jin Yun, Ka-Jung Jun, Kuniharu Komori, Mi Jin Lee, Myung-Hee Kwon, Yong-Joon Chwae, Kyongmin Kim, Ho-Joon Shin, Sun Park Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3 […]

The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

Publication date: July 2016 Source:Molecular Immunology, Volume 75 Author(s): Su Jin Yun, Ka-Jung Jun, Kuniharu Komori, Mi Jin Lee, Myung-Hee Kwon, Yong-Joon Chwae, Kyongmin Kim, Ho-Joon Shin, Sun Park Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3 […]

Metastatic Basosquamous Carcinoma

Report of Two Cases and Clinicopathological Considerations: Basosquamous carcinoma is a rare cutaneous tumor considered by some authors as an aggressive type of basal cell carcinoma having a propensity for local recurrence and a potential risk for regional and distant metastatic spread. Herein we present 2 cases of basosquamous carcinoma of head and neck region, […]

Epidermotropic metastasis of primary lung adenocarcinoma

Epidermotropic metastasis of primary lung adenocarcinoma: Abstract Cutaneous metastasis of lung cancer is a rare event and usually portends a grim prognosis. Several cases of lung cancer with cutaneous metastasis have been reported, but these have been largely limited to the dermis. Here we describe a unique case of cutaneous metastatic lung adenocarcinoma largely limited […]

Activating KRAS mutations are characteristic of oncocytic sinonasal papilloma and associated sinonasal squamous cell carcinoma

Activating KRAS mutations are characteristic of oncocytic sinonasal papilloma and associated sinonasal squamous cell carcinoma: ABSTRACT Oncocytic sinonasal papillomas (OSP) are benign tumours of the sinonasal tract, a subset of which are associated with synchronous or metachronous sinonasal squamous cell carcinoma (SNSCC). Activating EGFR mutations were recently identified in nearly 90% of inverted sinonasal papillomas […]

Bone fragility and loss is a significant cause of morbidity in patients with cystic fibrosis (CF)

Over-expression of RANKL in osteoblasts: a possible mechanism of susceptibility to bone disease in cystic fibrosis: Abstract Bone fragility and loss is a significant cause of morbidity in patients with cystic fibrosis (CF), and the lack of effective therapeutic options means that treatment is more often palliative rather than curative. A deeper understanding of the […]

Upregulation of miR-455-5p by the TGF-β–SMAD signalling axis promotes the prolif eration of OSC cells

by targeting UBE2B: Abstract MicroRNAs (miRNAs) are involved in the tumourigenesis of various cancers by regulating their downstream targets. To identify the changes of miRNAs in oral squamous cell carcinoma (OSCC), we investigated the expression profiles of miRNAs in 40 pairs of OSCC specimens and their matched non-tumour epithelial tissues. Our data revealed higher miR-455-5p […]

ESCC : Poly (C) − binding protein 2 (PCBP2) promotes the progression through regulating cellular prolif eration and apoptosis

Poly (C) − binding protein 2 (PCBP2) promotes the progression of esophageal squamous cell carcinoma (ESCC) through regulating cellular proliferation and apoptosis via ScienceDirect Publication: Pathology – Research and Practice Publication date: Available online 27 May 2016 Source:Pathology – Research and Practice Author(s): Jinjun Ye, Guoren Zhou, Zhi Zhang, Lei Sun, Xia He, Jianwei Zhou […]

Respiratory Hypersensitivity Reactions to NSAIDs

in Europe: The Global Allergy and Asthma Network (GA2LEN) Survey: Abstract Background Non-steroidal Anti-Inflammatory Drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAIDs-induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders. […]

The Patient-Oriented Eczema Measure in young children

responsiveness and minimal clinically important difference: Abstract Background The Patient-Oriented Eczema Measure (POEM) has been recommended as the core patient-reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomised feasibility study we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of […]

The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Publication date: July 2016 *Source:*Molecular Immunology, Volume 75 Author(s): Su Jin Yun, Ka-Jung Jun, Kuniharu Komori, Mi Jin Lee, Myung-Hee Kwon, Yong-Joon Chwae, Kyongmin Kim, Ho-Joon Shin, Sun Park Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3 transcription are poorly understood. In the present study, we investigated whether methylation of the TIM-3 promoter is involved in regulatingTIM-3 transcription in T cells, and identified a transcription factor th... περισσότερα »

The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 22 δευτερόλεπτα
Publication date: July 2016 *Source:*Molecular Immunology, Volume 75 Author(s): Su Jin Yun, Ka-Jung Jun, Kuniharu Komori, Mi Jin Lee, Myung-Hee Kwon, Yong-Joon Chwae, Kyongmin Kim, Ho-Joon Shin, Sun Park Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3 transcription are poorly understood. In the present study, we investigated whether methylation of the TIM-3 promoter is involved in regulatingTIM-3 transcription in T cells, and identified a transcription factor th... περισσότερα »

Endothelial Progenitor Cells in Diabetic Microvascular Complications: Friends or Foes?

Despite being featured as metabolic disorder, diabetic patients are largely affected by hyperglycemia-induced vascular abnormality. Accumulated evidence has confirmed the beneficial effect of endothelial progenitor cells (EPCs) in coronary heart disease. However, antivascular endothelial growth factor (anti-VEGF) treatment is the main therapy for diabetic retinopathy and nephropathy, indicating the uncertain role of EPCs in the […]

Mesenchymal Stem Cells and Metabolic Syndrome: Current Understanding and Potential Clinical Implications

Metabolic syndrome is an obesity-based, complicated clinical condition that has become a global epidemic problem with a high associated risk for cardiovascular disease and mortality. Dyslipidemia, hypertension, and diabetes or glucose dysmetabolism are the major factors constituting metabolic syndrome, and these factors are interrelated and share underlying pathophysiological mechanisms. Severe obesity predisposes individuals to metabolic […]

Invisible Victims: Delayed Onset Depression among Adults with Same-Sex Parents

The relationship of elevated depression risk recently discovered among adult persons raised by same-sex parents with possible precipitating conditions in childhood has not previously been acknowledged. This study tests whether such inattention is supportable. Logistic regression based risk ratios were estimated from longitudinal measures of mental health outcomes observed in three waves (at ages 15, […]

Locating Minimal Fault Interaction in Combinatorial Testing

Combinatorial testing (CT) technique could significantly reduce testing cost and increase software system quality. By using the test suite generated by CT as input to conduct black-box testing towards a system, we are able to detect interactions that trigger the system’s faults. Given a test case, there may be only part of all its parameters […]

Ethylene-Induced Vinblastine Accumulation Is Related to Activated Expression of Downstream TIA Pathway Genes in Catharanthus roseus

We selected different concentrations of ethephon, to stress C. roseus. We used qRT-PCR and HPLC followed by PCA to obtain comprehensive profiling of the vinblastine biosynthesis in response to ethephon. Based on our findings, the results showed that the high concentration of ethephon had a positive effect at both transcriptional and metabolite level. Meanwhile, there […]

Preconception Care: A New Standard of Care within Maternal Health Services

Emerging research suggests that much pediatric affliction has origins in the vulnerable phase of fetal development. Prenatal factors including deficiency of various nutrients and exposure to assorted toxicants are major etiological determinants of myriad obstetrical complications, pediatric chronic diseases, and perhaps some genetic mutations. With recent recognition that modifiable environmental determinants, rather than genetic predestination, […]

Impact of Climate Change on Hydrologic Extremes in the Upper Basin of the Yellow River Basin of China

To reveal the revolution law of hydrologic extremes in the next 50 years and analyze the impact of climate change on hydrologic extremes, the following main works were carried on: firstly, the long duration (15 d, 30 d, and 60 d) rainfall extremes according to observed time-series and forecast time-series by dynamical climate model product (BCC-CSM-1.1) were deduced, […]

Maximizing Outcomes While Minimizing Morbidity: An Illustrated Case Review of Elbow Soft Tissue Reconstruction

Background. Injuries to the elbow have led to consequences varying from significant limitation in function to loss of the entire upper limb. Soft tissue reconstruction with durable and pliable coverage balanced with the ability to mobilize the joint early to optimize rehabilitation outcomes is paramount. Methods. Methods of flap reconstruction have evolved from local and […]

Oregano Essential Oil Improves Intestinal Morphology and Expression of Tight Junction Proteins Associated with Modulation of Selected Intestinal Bacteria and Immune Status in a Pig Model

Oregano essential oil (OEO) has long been used to improve the health of animals, particularly the health of intestine, which is generally attributed to its antimicrobial and anti-inflammatory effects. However, how OEO acts in the intestine of pig is still unclear. This study was aimed at elucidating how OEO promotes the intestinal barrier integrity in […]

Hemispatial Neglect Shows That “Before” Is “Left”

Recent research has led to the hypothesis that events which unfold in time might be spatially represented in a left-to-right fashion, resembling writing direction. Here we studied fourteen right-hemisphere damaged patients, with or without neglect, a disorder of spatial awareness affecting contralesional (here left) space processing and representation. We reasoned that if the processing of […]

Endoscopic Septoplasty—Two Handed Technique with Endoscope Holder: A Novel Approach

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 35 δευτερόλεπτα
Abstract The popularity of endoscopes has been expanding not only in diagnostics but also in therapeutics. The traditional septal surgery also has come under the purview of endoscopic surgery in the last few decades. Endoscopic septoplasty has definitely many advantages over the conventional procedure. But the only disadvantage of endoscopic surgery is that it is… Continue reading Endoscopic Septoplasty—Two Handed Technique with Endoscope Holder: A Novel Approach

A Short Term Subjective and Objective Analysis of Modified Endoscopic Lothrop’s Procedure and Its Functional Outcome: Our Experience

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 35 δευτερόλεπτα
Abstract To study the short-term functional outcomes of the endoscopic modified Lothrop procedure with well defined subjective and objective criteria. It’s a retrospective cohort study with chart review carried out at a tertiary referral center. 31 patients with chronic frontal sinusitis who underwent endoscopic modified Lothrop’s procedure with uncinate preservation during the period Jan 2011–2014… Continue reading A Short Term Subjective and Objective Analysis of Modified Endoscopic Lothrop’s Procedure and Its Functional Outcome: Our Experience

The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 35 δευτερόλεπτα
Publication date: July 2016 Source:Molecular Immunology, Volume 75 Author(s): Su Jin Yun, Ka-Jung Jun, Kuniharu Komori, Mi Jin Lee, Myung-Hee Kwon, Yong-Joon Chwae, Kyongmin Kim, Ho-Joon Shin, Sun Park Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3… Continue reading The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

Work disruption in operating rooms hinders flow of patients and increases chances of error

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Impact of disruptions on anaesthetic workflow during anaesthesia induction and patient positioning: A prospective study.: BACKGROUND: Work disruption in operating rooms hinders flow of patients and increases chances of error. Previous studies have largely considered the types of disruption occurring in operating rooms, but have not analysed systematically the objective impact of disruption. OBJECTIVE: The objective was to evaluate the impact of disruption on time efficiency in preoperative anaesthetic work in the operating room and to link disruption to failures in co-ordination of ... περισσότερα »

FTSG on the Face: Do We Really Need Tie-over Dressings or Quilting Sutures?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
FTSG on the Face: Do We Really Need Tie-over Dressings or Quilting Sutures?: *Chasapi, Maria MD, MRCS; Salibi, Andrej MD, MRCS, MSc* *[image: Collapse Box]*Author Information *Plastic Surgery Department, Royal Preston Hospital, Preston, Lancashire, United Kingdom* *Correspondence to Maria Chasapi, MD, MRCS, Plastic Surgery Department, Royal Preston Hospital, Preston, Lancashire PR2 9HT, United Kingdom, E-mail:Maria.Chasapi@lthtr.nhs.uk* *This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-N...περισσότερα »

How Do You Know When It Is Time to Retire?

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
How Do You Know When It Is Time to Retire?: Stevenson, Thomas R. M.D. Plastic Surgery, University of California Davis School of Medicine, Davis, Calif. Sir: On July 1, after practicing medicine for 43 years, I voluntarily left my profession. Recently, a friend asked me how I knew it was time for me to retire. There are easier questions for a 69-year-old plastic surgeon to answer. “What should be done about sagging facial skin and an appearance of being tired?” or “Can you make my drooping breasts look better?”The basic retirement timing question actually is composed ... περισσότερα »

Management of the Salivary Glands and Facial Nerve

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
in Face Transplantation: [image: image]Background: Since the first face transplant in 2005, 35 cases have been performed worldwide with acceptable graft survival and satisfactory return of function and appearance. With increasing experience, it is emerging that the salivary glands can contribute to the challenges encountered in the perioperative period. Methods: A comprehensive review of the literature regarding management of the salivary glands and facial nerve in facial transplantation was performed. Data gathered included inclusion or exclusion of submandibular and parotid glan... περισσότερα »

The Effect of Norepinephrine and Dopamine on Radial Forearm Flap Partial Tissue Oxygen Pressure and Microdialysate Metabolite Measurements

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
A Randomized Controlled Trial: Background: Patients undergoing ablative and reconstructive head and neck surgery with a microvascular flap have multiple factors that potentially decrease postoperative mean arterial pressure, which may endanger flap survival. The safety of vasopressor use has long been a topic of discussion. The authors analyzed the effect of vasopressors on microvascular flap perfusion after head and neck cancer reconstruction. Methods: A total of 27 patients were enrolled in a randomized, controlled, clinical trial. A microvascular radial forearm flap was used for... περισσότερα »

Anterolateral Thigh Perforator Flap: Application of Computed Tomography Angiography Mapping and Located Template for Accurate Location of Perforator

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Application of Computed Tomography Angiography Mapping and Located Template for Accurate Location of Perforator in Head and Neck Reconstruction with Anterolateral Thigh Perforator Flap: [image: image] Background: The authors introduce a new method of preoperative computed tomography angiography mapping and virtual and printed located template for accurate location of perforators in the anterolateral thigh perforator flap for head and neck reconstruction. Methods: Between April and December of 2014, a cohort study was performed with 29 patients who underwent head and neck reconstruc...περισσότερα »

Local Free-Style Perforator Flaps in Head and Neck Reconstruction

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
An Update and a Useful Classification: Background: Any standard skin flap of the body including a detectable or identified perforator at its axis can be safely designed and harvested in a free-style fashion. Methods: Fifty-six local free-style perforator flaps in the head and neck region, 33 primary and 23 recycle flaps, were performed in 53 patients. The authors introduced the term “recycle” to describe a perforator flap harvested within the borders of a previously transferred flap. A Doppler device was routinely used preoperatively for locating perforators in the area adjacent to... περισσότερα »

A Novel Technique for Seal Augmentation in Negative-Pressure Wound Therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
A Novel Technique for Seal Augmentation in Negative-Pressure Wound Therapy: Author Information Plastic Surgery Department, James Cook University Hospital, Middlesbrough, United Kingdom Correspondence to Dr. Katechia, Department of Plastic Surgery, James Cook University Hospital, Middlesbrough TS4 3BW, United Kingdom, d.katechia@nhs.net Back to Top | Article Outline Sir: We have read with great pleasure the article by Kim et al. entitled “Comparison of Outcomes for Normal Saline and an Antiseptic Solution for Negative-Pressure Wound Therapy with Instillation.”1 We co... περισσότερα »

Malignant Pyoderma Associated with Granulomatosis with Polyangiitis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
(Wegener Granulomatosis) as a Unique Indication for Facial Vascularized Composite Allotransplantation: Part I: Background: Granulomatosis with polyangiitis (Wegener granulomatosis) is a rare disease that commonly starts in the craniofacial region and can lead to considerable facial disfigurement. Granulomas and vasculitis, however, can involve many other tissues (especially pulmonary and renal). Dermatologic and subcutaneous components can lead to malignant pyoderma. Methods: The authors describe a unique pathologic condition, where significant Le Fort type trauma was associated w... περισσότερα »

Normal Saline and an Antiseptic Solution for Negative-Pressure Wound Therapy with Instillation

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Comparison of Outcomes for Author Information Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Correspondence to Dr. Qi, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 33 Badachu Road, Shijingshan District, Beijing 100068, People’s Republic of China, qizuoliangls@163.com Sir: We read with interest the recent article entitled “Comparison of Outcomes for Normal Saline and an Antiseptic Solution for Negative-Pressure Wound Therapy with In...περισσότερα »

Simultaneous Scalp, Skull, Kidney, and Pancreas Transplant

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
from a Single Donor: [image: image]Background: Vascularized composite allotransplantation is an emerging field, but the complications of lifelong immunosuppression limit indications. Vascularized composite allotransplantation in solid organ recipients represents a unique opportunity because immunosuppression has already been accepted. This report of a simultaneous scalp, skull, kidney, and pancreas transplant represents both the first skull-scalp transplant and combination of a vascularized composite allotransplantation with double organ transplantation. Methods: A previous reci... περισσότερα »

Complication Rates in Delayed Mohs Reconstruction Surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Complication Rates in Delayed Mohs Reconstruction Surgery: This multi-institutional cohort study describes the frequency of and predictors of complications in patients undergoing delayed facial reconstruction after Mohs micrographic surgery. Importance Same-day Mohs reconstructive surgery is not always possible owing to patient factors, scheduling, and complexity of defect, but there is hesitancy in delaying closure of such defects. Objective To describe the frequency of and predictors of complications in patients undergoing delayed facial reconstruction after Mohs microgr... περισσότερα »

Nasal Anatomy in Cleft Lip and Palate of Skeletally Mature Patients

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Nasal Anatomy in Cleft Lip and Palate of Skeletally Mature Patients: This study assesses how the cartilaginous and bony septum contribute to airway obstruction in skeletally mature patients with cleft lip and palate. *Importance* Septal deviation commonly occurs in patients with cleft lip and palate (CLP); however, the contribution of the cartilaginous and bony septum to airway obstruction in skeletally mature patients is poorly understood. *Objectives* To describe the internal nasal airway anatomy of skeletally mature patients with CLP and to determine the contributors to air... περισσότερα »

The history of pediatric plastic surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Histoire de la chirurgie plastique pédiatrique via Plastique Esthétique *Source:*Annales de Chirurgie Plastique Esthétique Author(s): J. Glicenstein L’histoire de la chirurgie plastique pédiatrique est liée à celle de la pédiatrie. Avant le XIXe siècle, il n’y avait pas d’hôpitaux d’enfants. Seules, quelques interventions (la fermeture simple des fentes labiales, l’ablation d’un doigt surnuméraire) étaient pratiquées avant que l’anesthésie, l’asepsie et l’antisepsie les rendent moins dangereuses. Dès le XIXe siècle, des interventions furent proposées pour le traitement des fentes la... περισσότερα »

Risk factors of microtia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
A systematic review and meta-analysis: Abstract BackgroundThe pathogenesis of microtia is still unclear. Various risk factors have been studied but they remain inconclusive. We conducted the first ever systematic review and meta-analysis to look for the association between microtia and various environmental risk factors. MethodsRelevant case-control studies published between January 2000 to October 2014 were identified through a systematic search in PubMed and EMBASE. Reference lists from relevant review articles were also searched. Studies were included if they meet our selec...περισσότερα »

Oral leukoplakia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Web-based information on the treatment of oral leukoplakia – quality and readability: Objective To categorise the content and assess the quality and readability of the online information regarding the treatment for oral leukoplakia. Methods An online search using the term ‘leukoplakia treatment’ was carried out on 8th June 2015 using the Google search engine. The content, quality and readability of the first 100 sites were explored. The quality of the web information was assessed using the following tools, the DISCERN instrument and the Journal of the American Medical Association (J... περισσότερα »

Recombinant human bone morphogenetic protein-2 (rhBMP-2) in oral and maxillofacial surgery

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Scientific evidence on the use of Abstract PurposeThis study aimed to identify the main indications for the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for bone repair and maintenance in the maxilla and mandible through a review of clinical trials evaluating the viability of using rhBMP-2 to delay the installation of dental implants, thus allowing satisfactory bone formation and long-term osseointegration. MethodsLiterature search of the PubMed/Medline databases was performed using the following MeSH index terms—“bone morphogenetic protein 2” and “dentistry...περισσότερα »

Opportunistic pathogens such as staphylococci, enteric rods and Candida sp. tend to increase in prevalence after IMRT with or without chemotherapy, but not after surgical intervention

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Head and neck intensity modulated radiation therapy leads to an increase of opportunistic oral pathogens updated at 09:25 via ScienceDirect Publication: Oral Oncology Publication date: July 2016 *Source:*Oral Oncology, Volume 58 Author(s): Jennifer M. Schuurhuis, Monique A. Stokman, Max J.H. Witjes, Johannes A. Langendijk, Arie J. van Winkelhoff, Arjan Vissink, Frederik K.L. Spijkervet ObjectivesThe introduction of intensity modulated radiation therapy (IMRT) has led to new possibilities in the treatment of head and neck cancer (HNC). Limited information is available on how this more ...περισσότερα »

Level V lymphatics (LVN) can be safely omitted from the clinical target volume in locally advanced OPC without gross LVN involvement.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Cervical nodal level V can safely be omitted in the treatment of locally advanced oropharyngeal squamous cell carcinoma with definitive IMRT updated at 09:25 via ScienceDirect Publication: Oral Oncology Publication date: July 2016 *Source:*Oral Oncology, Volume 58 Author(s): Stanley Gutiontov, Jonathan Leeman, Benjamin Lok, Paul Romesser, Nadeem Riaz, C. Jillian Tsai, Nancy Lee, Sean McBride ObjectivesPatients treated with definitive chemoradiation for oropharyngeal squamous cell carcinoma (OPC) experience excellent outcomes but treatment toxicities remain significant. The adoption of ... περισσότερα »

Palbociclib,a selective cyclin dependent kinase 4/6 inhibitor, in combination with cetuximab

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
in patients with recurrent/metastatic head and neck squamous cell carcinoma: [image: gr1ac.sml] Activation of the epidermal growth factor receptor (EGFR) is the most common event in head and neck squamous cell carcinoma (HNSCC), resulting in cellular proliferation, angiogenesis, and radiation resistance [1]. The importance of EGFR signaling was demonstrated by trials that showed improvement in overall survival (OS) when the EGFR inhibitor cetuximab was added to radiation or chemotherapy [2,3]. However, the clinical benefit of cetuximab monotherapy is surprisingly modest, with ...περισσότερα »

Endoscopic Septoplasty—Two Handed Technique with Endoscope Holder

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
A Novel Approach: AbstractThe popularity of endoscopes has been expanding not only in diagnostics but also in therapeutics. The traditional septal surgery also has come under the purview of endoscopic surgery in the last few decades. Endoscopic septoplasty has definitely many advantages over the conventional procedure. But the only disadvantage of endoscopic surgery is that it is a single handed technique as the other hand is used for holding the endoscope which may compromise the overall surgical time as the hemostasis and suctioning of the surgical field off the blood cannot be ...περισσότερα »

Modified Endoscopic Lothrop’s Procedure

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
A Short Term Subjective and Objective Analysis of Modified Endoscopic Lothrop’s Procedure and Its Functional Outcome: Our Experience: AbstractTo study the short-term functional outcomes of the endoscopic modified Lothrop procedure with well defined subjective and objective criteria. It’s a retrospective cohort study with chart review carried out at a tertiary referral center. 31 patients with chronic frontal sinusitis who underwent endoscopic modified Lothrop’s procedure with uncinate preservation during the period Jan 2011–2014 were followed up for a period of minimum 6 months. As... περισσότερα »

Effect of low-level laser therapy after rapid maxillary expansion

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
a clinical investigation: AbstractTo evaluate the effectiveness low-level laser therapy (LLLT) on the repair of the mid palatal suture, after rapid maxillary expansion (RME). A single-operator, randomized single-blind placebo-controlled study was performed at the Orthodontic Department at the Dental Hospital of Bellvitge. Barcelona University, Hospitalet de Llobregat, Spain. Thirty-nine children (range 6–12 years old), completed RME and were randomized to receive active LLLT (*n* = 20) or placebo (*n* = 19). The laser parameters and dose were 660 nm, 100 mW, CW, InGaAlP laser, il... περισσότερα »

pH-Sensitive Bioenergetic Nucleotide Nanoparticles Intranasal Delivery for Reduced Brain Infarction in Energy/Oxygen-Depleted Cells

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
Enhanced Cell Survival of pH-Sensitive Bioenergetic Nucleotide Nanoparticles in Energy/Oxygen-Depleted Cells and Their Intranasal Delivery for Reduced Brain Infarction via Acta Biomaterialia *Source:*Acta Biomaterialia Author(s): Yeon Su Choi, Dong Youl Cho, Hye-Kyung Lee, Jung-Kyo Cho, Don Haeng Lee, You Han Bae, Ja-Kyeong Lee, Han Chang Kang Nucleotides (NTs) (e.g., adenosine triphosphate) are very important molecules in the body. They generate bioenergy through phosphate group release, are involved in various biological processes and are used to treat various diseases that involve... περισσότερα »

Release of bioactive peptides from polyurethane films

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 42 δευτερόλεπτα
in vitro and in vivo: Effect of polymer composition via Acta Biomaterialia *Source:*Acta Biomaterialia Author(s): Jing Zhang, Trent M. Woodruff, Richard J. Clark, Darren J. Martin, Rodney F. Minchin Thermoplastic polyurethanes (TPUs) are widely used in biomedical applications due to their excellent biocompatibility. Their role as matrices for the delivery of small molecule therapeutics has been widely reported. However, very little is known about the release of bioactive peptides from this class of polymers. Here, we report the release of linear and cyclic peptides from TPUs with di... περισσότερα »

The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

Publication date: July 2016 Source:Molecular Immunology, Volume 75 Author(s): Su Jin Yun, Ka-Jung Jun, Kuniharu Komori, Mi Jin Lee, Myung-Hee Kwon, Yong-Joon Chwae, Kyongmin Kim, Ho-Joon Shin, Sun Park Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3 […]

Level V lymphatics (LVN) can be safely omitted from the clinical target volume in locally advanced OPC without gross LVN involvement.

Cervical nodal level V can safely be omitted in the treatment of locally advanced oropharyngeal squamous cell carcinoma with definitive IMRT updated at 09:25 via ScienceDirect Publication: Oral Oncology Publication date: July 2016 Source:Oral Oncology, Volume 58 Author(s): Stanley Gutiontov, Jonathan Leeman, Benjamin Lok, Paul Romesser, Nadeem Riaz, C. Jillian Tsai, Nancy Lee, Sean McBride […]

Palbociclib,a selective cyclin dependent kinase 4/6 inhibitor, in combination with cetuximab

in patients with recurrent/metastatic head and neck squamous cell carcinoma: Activation of the epidermal growth factor receptor (EGFR) is the most common event in head and neck squamous cell carcinoma (HNSCC), resulting in cellular proliferation, angiogenesis, and radiation resistance [1]. The importance of EGFR signaling was demonstrated by trials that showed improvement in overall survival […]

Endoscopic Septoplasty—Two Handed Technique with Endoscope Holder

A Novel Approach: Abstract The popularity of endoscopes has been expanding not only in diagnostics but also in therapeutics. The traditional septal surgery also has come under the purview of endoscopic surgery in the last few decades. Endoscopic septoplasty has definitely many advantages over the conventional procedure. But the only disadvantage of endoscopic surgery is […]

Modified Endoscopic Lothrop’s Procedure

A Short Term Subjective and Objective Analysis of Modified Endoscopic Lothrop’s Procedure and Its Functional Outcome: Our Experience: Abstract To study the short-term functional outcomes of the endoscopic modified Lothrop procedure with well defined subjective and objective criteria. It’s a retrospective cohort study with chart review carried out at a tertiary referral center. 31 patients […]

Effect of low-level laser therapy after rapid maxillary expansion

a clinical investigation: Abstract To evaluate the effectiveness low-level laser therapy (LLLT) on the repair of the mid palatal suture, after rapid maxillary expansion (RME). A single-operator, randomized single-blind placebo-controlled study was performed at the Orthodontic Department at the Dental Hospital of Bellvitge. Barcelona University, Hospitalet de Llobregat, Spain. Thirty-nine children (range 6–12 years old), […]

pH-Sensitive Bioenergetic Nucleotide Nanoparticles Intranasal Delivery for Reduced Brain Infarction in Energy/Oxygen-Depleted Cells

Enhanced Cell Survival of pH-Sensitive Bioenergetic Nucleotide Nanoparticles in Energy/Oxygen-Depleted Cells and Their Intranasal Delivery for Reduced Brain Infarction via Acta Biomaterialia Source:Acta Biomaterialia Author(s): Yeon Su Choi, Dong Youl Cho, Hye-Kyung Lee, Jung-Kyo Cho, Don Haeng Lee, You Han Bae, Ja-Kyeong Lee, Han Chang Kang Nucleotides (NTs) (e.g., adenosine triphosphate) are very important molecules […]

Release of bioactive peptides from polyurethane films

in vitro and in vivo: Effect of polymer composition via Acta Biomaterialia Source:Acta Biomaterialia Author(s): Jing Zhang, Trent M. Woodruff, Richard J. Clark, Darren J. Martin, Rodney F. Minchin Thermoplastic polyurethanes (TPUs) are widely used in biomedical applications due to their excellent biocompatibility. Their role as matrices for the delivery of small molecule therapeutics has […]

Auditory training improves auditory performance

in cochlear implanted children via Hearing Research Source:Hearing Research Author(s): Stephane Roman, Françoise Rochette, Jean-Michel Triglia, Daniele Schön, Emmanuel Bigand While the positive benefits of pediatric cochlear implantation on language perception skills are now proven, the heterogeneity of outcomes remains high. The understanding of this heterogeneity and possible strategies to minimize it is of utmost […]

Tinnitus

A systematic review of the reporting of tinnitus prevalence and severity via Hearing Research Source:Hearing Research Author(s): Abby McCormack, Mark Edmondson-Jones, Sarah Somerset, Deborah Hall IntroductionThere is no standard diagnostic criterion for tinnitus, although some clinical assessment instruments do exist for identifying patient complaints. Within epidemiological studies the presence of tinnitus is determined primarily by […]

Post-auricular route surgery

Technical note for post-auricular route surgery in Mongolian gerbil via Hearing Research Publication date: Available online 28 May 2016 Source:Hearing Research Author(s): Michaël Risoud, Nicolas-Xavier Bonne, Martin Fourdrinier, Thomas Hubert, Christophe Vincent The Mongolian gerbil (Meriones unguiculatus) is commonly used in hearing research because the hearing frequency spectrum of the gerbil is rather similar to […]

The regulation of TIM-3 transcription in T cells involves c-Jun binding but not CpG methylation at the TIM-3 promoter

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 1 ώρα
Publication date: July 2016 *Source:*Molecular Immunology, Volume 75 Author(s): Su Jin Yun, Ka-Jung Jun, Kuniharu Komori, Mi Jin Lee, Myung-Hee Kwon, Yong-Joon Chwae, Kyongmin Kim, Ho-Joon Shin, Sun Park Tim-3 is an immunomodulatory protein that is expressed constitutively on monocytes but is induced in activated T cells. The mechanisms involved in the regulation of TIM-3 transcription are poorly understood. In the present study, we investigated whether methylation of the TIM-3 promoter is involved in regulatingTIM-3 transcription in T cells, and identified a transcription factor th... περισσότερα »

Efficacy of daclatasvir/asunaprevir according to resistance-associated variants in chronic hepatitis C with genotype 1

Abstract Background The present study explored the treatment outcome of daclatasvir (DCV) and asunaprevir (ASV) therapy combining oral direct-acting antiviral agents (DAAs) for chronic hepatitis C (HCV) including liver cirrhosis according to resistance-associated variants (RAVs) in NS3/NS5A region. Methods Overall, 641 patients enrolled in Japan with HCV-1b received DCV and ASV for 24 weeks. Baseline […]

Mechanisms of Change in the ARC Organizational Strategy: Increasing Mental Health Clinicians’ EBP Adoption Throug h Improved Organizational Culture and Capacity

Abstract The development of efficient and scalable implementation strategies in mental health is restricted by poor understanding of the change mechanisms that increase clinicians’ evidence-based practice (EBP) adoption. This study tests the cross-level change mechanisms that link an empirically-supported organizational strategy for supporting implementation (labeled ARC for Availability, Responsiveness, and Continuity) to mental health clinicians’ […]

Mechanisms of Change in the ARC Organizational Strategy: Increasing Mental Health Clinicians’ EBP Adoption Throug h Improved Organizational Culture and Capacity

Abstract The development of efficient and scalable implementation strategies in mental health is restricted by poor understanding of the change mechanisms that increase clinicians’ evidence-based practice (EBP) adoption. This study tests the cross-level change mechanisms that link an empirically-supported organizational strategy for supporting implementation (labeled ARC for Availability, Responsiveness, and Continuity) to mental health clinicians’ […]

Scientific evidence on the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in oral and maxillofacial surgery

Abstract Purpose This study aimed to identify the main indications for the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for bone repair and maintenance in the maxilla and mandible through a review of clinical trials evaluating the viability of using rhBMP-2 to delay the installation of dental implants, thus allowing satisfactory bone formation and […]

GIRL’S FIRST CAVITY FILLING

The post GIRL’S FIRST CAVITY FILLING appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1RBsCXv via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1sjdJEB via IFTTT

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
The Journal of pathology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSQJy via IFTTT

Visceral disease in castration-resistant prostate cancer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
European urology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLScI via IFTTT

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Nature genetics from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSCCj via IFTTT

Phase I Trials in Patients with Relapsed, Advanced Upper Gastrointestinal Carcinomas – Experience in a Specialist Unit

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLw5W via IFTTT

Expected Satiety: Application to Weight Management and Understanding Energy Selection in Humans

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Current obesity reports from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSHG5 via IFTTT

Deep brain recordings using an implanted pulse generator in Parkinson’s disease

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Neuromodulation : journal of the International Neuromodulation Society from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLeMm via IFTTT

Label-free detection of glycoproteins by the lectin biosensor down to attomolar level using gold nanoparticles

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Talanta from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSliz via IFTTT

Prevalence and comparison of Streptococcus infantarius subsp. infantarius and Streptococcus gallolyticus subsp. macedonicus in raw and fermented dairy products from East and West Africa

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
International journal of food microbiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLyea via IFTTT

Predicting Fractures in an International Cohort using Risk Factor Algorithms, Without Bone Mineral Density

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSKSd via IFTTT

Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLtXX via IFTTT

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells

The Journal of pathology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSQJy via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Visceral disease in castration-resistant prostate cancer

European urology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLScI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

Nature genetics from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSCCj via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Phase I Trials in Patients with Relapsed, Advanced Upper Gastrointestinal Carcinomas – Experience in a Specialist Unit

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLw5W via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Expected Satiety: Application to Weight Management and Understanding Energy Selection in Humans

Current obesity reports from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSHG5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Deep brain recordings using an implanted pulse generator in Parkinson’s disease

Neuromodulation : journal of the International Neuromodulation Society from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLeMm via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Label-free detection of glycoproteins by the lectin biosensor down to attomolar level using gold nanoparticles

Talanta from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSliz via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Prevalence and comparison of Streptococcus infantarius subsp. infantarius and Streptococcus gallolyticus subsp. macedonicus in raw and fermented dairy products from East and West Africa

International journal of food microbiology from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLyea via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Predicting Fractures in an International Cohort using Risk Factor Algorithms, Without Bone Mineral Density

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1NVSKSd via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Previous Fractures at Multiple Sites Increase the Risk for Subsequent Fractures: The Global Longitudinal Study of Osteoporosis in Women

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1qTLtXX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174

Minimal invasive treatment of life-threatening bleeding caused by cardiopulmonary resuscitation-associated liver injury: a case report

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Background Life-threatening bleeding caused by liver injury due to chest compressions is a rare complication in otherwise successful cardiopulmonary resuscitation. Surgical intervention has been suggested to achieve bleeding control; however, reported mortality is high. In this report, we present a brief literature review and a case report in which use of a less invasive… Continue reading Minimal invasive treatment of life-threatening bleeding caused by cardiopulmonary resuscitation-associated liver injury: a case report

Second-line tests in the differential diagnosis of ACTH-dependent Cushing’s syndrome

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Abstract Introduction Diagnosing Cushing’s syndrome (CS) can be a challenge, especially in ACTH-dependent CS, when it comes to detecting the origin of ACTH secretion. Materials and methods Retrospective data were collected on 170 patients with ACTH-dependent CS (149 CD, 21 EAS) referring to two endocrinology units, focusing on three non-invasive tests: dexamethasone 8 mg overnight… Continue reading Second-line tests in the differential diagnosis of ACTH-dependent Cushing’s syndrome

The association between social support and smoking status in cancer survivors with frequent and infrequent mental distress: results from 10 US states, 2010

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Conclusions Rates of current smokers were lower among cancer survivors who received social support and reported infrequent mental distress. Implications for Cancer Survivors Psychosocial screening may help health care professional identify smokers with frequent mental distress who require more intensive smoking cessation interventions. (Source: Journal of Cancer Survivorship) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1sF4WN1… Continue reading The association between social support and smoking status in cancer survivors with frequent and infrequen... περισσότερα »

Minimal invasive treatment of life-threatening bleeding caused by cardiopulmonary resuscitation-associated liver injury: a case report

Abstract Background Life-threatening bleeding caused by liver injury due to chest compressions is a rare complication in otherwise successful cardiopulmonary resuscitation. Surgical intervention has been suggested to achieve bleeding control; however, reported mortality is high. In this report, we present a brief literature review and a case report in which use of a less invasive […]

Second-line tests in the differential diagnosis of ACTH-dependent Cushing’s syndrome

Abstract Introduction Diagnosing Cushing’s syndrome (CS) can be a challenge, especially in ACTH-dependent CS, when it comes to detecting the origin of ACTH secretion. Materials and methods Retrospective data were collected on 170 patients with ACTH-dependent CS (149 CD, 21 EAS) referring to two endocrinology units, focusing on three non-invasive tests: dexamethasone 8 mg overnight […]

The association between social support and smoking status in cancer survivors with frequent and infrequent mental distress: results from 10 US states, 2010

Conclusions Rates of current smokers were lower among cancer survivors who received social support and reported infrequent mental distress. Implications for Cancer Survivors Psychosocial screening may help health care professional identify smokers with frequent mental distress who require more intensive smoking cessation interventions. (Source: Journal of Cancer Survivorship) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1sF4WN1 […]

Efficacy of daclatasvir/asunaprevir according to resistance-associated variants in chronic hepatitis C with genotype 1

Abstract Background The present study explored the treatment outcome of daclatasvir (DCV) and asunaprevir (ASV) therapy combining oral direct-acting antiviral agents (DAAs) for chronic hepatitis C (HCV) including liver cirrhosis according to resistance-associated variants (RAVs) in NS3/NS5A region. Methods Overall, 641 patients enrolled in Japan with HCV-1b received DCV and ASV for 24 weeks. Baseline drug-resistant mutations L31F/I/M/V, Q54H, P58S, A92K, and Y93H in the HCV NS5A region and V36A, T54A/S, Q80K/L/R, R155K/T/Q, A156S/V/T, and D168A/E/H/T/V in the HCV NS3/4A region wer... περισσότερα »

Mechanisms of Change in the ARC Organizational Strategy: Increasing Mental Health Clinicians’ EBP Adoption Through Improved Organizational Culture and Capacity

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
Abstract The development of efficient and scalable implementation strategies in mental health is restricted by poor understanding of the change mechanisms that increase clinicians’ evidence-based practice (EBP) adoption. This study tests the cross-level change mechanisms that link an empirically-supported organizational strategy for supporting implementation (labeled ARC for Availability, Responsiveness, and Continuity) to mental health clinicians’ EBP adoption and use. Four hundred seventy-five mental health clinicians in 14 children’s mental health agencies were randomly assigned...περισσότερα »

The Healthcare Needs of Latinos with Serious Mental Illness and the Potential of Peer Navigators

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες
Abstract Latinos with serious mental illness get sick and die much younger than other adults. In this paper, we review findings of a community based participatory research project meant to identify important healthcare needs, barriers to these needs, solutions to the barriers, and the promise of peer navigators as a solution. Findings from focus groups reflected general concerns of people with mental illness (e.g., insurance, engagement, accessibility) and Latinos with serious mental illness (e.g., immigration, language, and family). Feedback and analyses especially focused on the ... περισσότερα »

Scientific evidence on the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in oral and maxillofacial surgery

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες
AbstractPurpose This study aimed to identify the main indications for the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for bone repair and maintenance in the maxilla and mandible through a review of clinical trials evaluating the viability of using rhBMP-2 to delay the installation of dental implants, thus allowing satisfactory bone formation and long-term osseointegration. Methods Literature search of the PubMed/Medline databases was performed using the following MeSH index terms—“bone morphogenetic protein 2” and “dentistry”. Only clinical trials necessarily pu... περισσότερα »

GIRL’S FIRST CAVITY FILLING

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 2 ώρες
The post GIRL’S FIRST CAVITY FILLING appeared first on Family Dentistry and Cosmetic Surgery Clinic. from #Dental via xlomafota13 on Inoreader http://ift.tt/1RBsCXv via IFTTT

Scientific evidence on the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in oral and maxillofacial surgery

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Abstract Purpose This study aimed to identify the main indications for the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for bone repair and maintenance in the maxilla and mandible through a review of clinical trials evaluating the viability of using rhBMP-2 to delay the installation of dental implants, thus allowing satisfactory bone formation and long-term osseointegration. Methods Literature search of the PubMed/Medline databases was performed using the following MeSH index terms—"bone morphogenetic protein 2" and "dentistry". Only clinical trials necessarily... περισσότερα »

Mechanisms of Change in the ARC Organizational Strategy: Increasing Mental Health Clinicians’ EBP Adoption Through Improved Organizational Culture and Capacity

Abstract The development of efficient and scalable implementation strategies in mental health is restricted by poor understanding of the change mechanisms that increase clinicians' evidence-based practice (EBP) adoption. This study tests the cross-level change mechanisms that link an empirically-supported organizational strategy for supporting implementation (labeled ARC for Availability, Responsiveness, and Continuity) to mental health clinicians' EBP adoption and use. Four hundred seventy-five mental health clinicians in 14 children's mental health agencies were randomly assigne... περισσότερα »

The Healthcare Needs of Latinos with Serious Mental Illness and the Potential of Peer Navigators

Abstract Latinos with serious mental illness get sick and die much younger than other adults. In this paper, we review findings of a community based participatory research project meant to identify important healthcare needs, barriers to these needs, solutions to the barriers, and the promise of peer navigators as a solution. Findings from focus groups reflected general concerns of people with mental illness (e.g., insurance, engagement, accessibility) and Latinos with serious mental illness (e.g., immigration, language, and family). Feedback and analyses especially focused on the... περισσότερα »

Scientific evidence on the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in oral and maxillofacial surgery

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 ώρες
Abstract Purpose This study aimed to identify the main indications for the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for bone repair and maintenance in the maxilla and mandible through a review of clinical trials evaluating the viability of using rhBMP-2 to delay the installation of dental implants, thus allowing satisfactory bone formation and long-term osseointegration. Methods Literature search of the PubMed/Medline databases was performed using the following MeSH index terms—"bone morphogenetic protein 2" and "dentistry". Only clinical trials necessarily... περισσότερα 

Scientific evidence on the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in oral and maxillofacial surgery

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 ώρες
Abstract Purpose This study aimed to identify the main indications for the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) for bone repair and maintenance in the maxilla and mandible through a review of clinical trials evaluating the viability of using rhBMP-2 to delay the installation of dental implants, thus allowing satisfactory bone formation and long-term osseointegration. Methods Literature search of the PubMed/Medline databases was performed using the following MeSH index terms—"bone morphogenetic protein 2" and "dentistry". Only clinical trials necessarily... περισσότερα »

ZIOPHARM Highlightx Favorable Interim Survival Results with Gene Therapy Candidate Ad-RTS-hIL-12 in Brain Cancer

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
(Source: Clinical Trials And Noteworthy Treatments For Brain Tumors) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1TNwJEk via IFTTT

Prognostic value of preoperative von Willebrand factor plasma levels in patients with Glioblastoma

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Abstract Circulating biomarker for malignant gliomas could improve both differential diagnosis and clinical management of brain tumor patients. Among all gliomas, glioblastoma (GBM) is considered the most hypervascularized tumor with activation of multiple proangiogenic signaling pathways that enhance tumor growth. To investigate whether preoperative antigen plasma level of von Willebrand Factor (VWF:Ag) might be possible… Continue reading Prognostic value of preoperative von Willebrand factor plasma levels in patients with Glioblastoma

Understanding the relationship between safety investment and safety performance of construction projects through agent-based modeling

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Publication date: September 2016 Source:Accident Analysis & Prevention, Volume 94 Author(s): Miaojia Lu, Clara Man Cheung, Heng Li, Shu-Chien Hsu The construction industry in Hong Kong increased its safety investment by 300% in the past two decades; however, its accident rate has plateaued to around 50% for one decade. Against this backdrop, researchers have found… Continue reading Understanding the relationship between safety investment and safety performance of construction projects through agent-based modeling

Effect evaluation of a road safety education program based on victim testimonials in high schools in Belgium

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Publication date: September 2016 Source:Accident Analysis & Prevention, Volume 94 Author(s): Ariane Cuenen, Kris Brijs, Tom Brijs, Karin Van Vlierden, Stijn Daniels, Geert Wets For several decades policy makers worldwide have experimented with testimonials as a strategy to promote road safety supportive views in a wide variety of target populations such as recidivists and students.… Continue reading Effect evaluation of a road safety education program based on victim testimonials in high schools in Belgium

Heterogeneous impacts of gender-interpreted contributing factors on driver injury severities in single-vehicle rollover crashes

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Publication date: September 2016 Source:Accident Analysis & Prevention, Volume 94 Author(s): Qiong Wu, Guohui Zhang, Cong Chen, Rafiqul Tarefder, Haizhong Wang, Heng Wei In this study, a mixed logit model is developed to identify the heterogeneous impacts of gender-interpreted contributing factors on driver injury severities in single-vehicle rollover crashes. The random parameter of the variables… Continue reading Heterogeneous impacts of gender-interpreted contributing factors on driver injury severities in single-vehicle rollover crashes

Analysis of driver injury severity in single-vehicle crashes on rural and urban roadways

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Publication date: September 2016 Source:Accident Analysis & Prevention, Volume 94 Author(s): Qiong Wu, Guohui Zhang, Xiaoyu Zhu, Xiaoyue Cathy Liu, Rafiqul Tarefder This study analyzes driver injury severities for single-vehicle crashes occurring in rural and urban areas using data collected in New Mexico from 2010 to 2011. Nested logit models and mixed logit models are… Continue reading Analysis of driver injury severity in single-vehicle crashes on rural and urban roadways

Injury severity of pedestrians, bicyclists and motorcyclists resulting from crashes with reversing cars

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Publication date: September 2016 Source:Accident Analysis & Prevention, Volume 94 Author(s): Sebastian Decker, Dietmar Otte, Dana Leslie Cruz, Christian Walter Müller, Mohamed Omar, Christian Krettek, Stephan Brand ObjectivePedestrians, bicyclists and motorcyclists can suffer serious injury in road traffic crashes. To date, no studies examine the injury severity within this vulnerable cohort following collisions with reversing… Continue reading Injury severity of pedestrians, bicyclists and motorcyclists resulting from crashes with reversing cars

Mapping the nomological network of employee self-determined safety motivation: A preliminary measure in China

orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 2 ώρες
Publication date: September 2016 Source:Accident Analysis & Prevention, Volume 94 Author(s): Li Jiang, Lois E. Tetrick The present study introduced a preliminary measure of employee safety motivation based on the definition of self-determination theory from Fleming (2012) research and validated the structure of self-determined safety motivation (SDSM) by surveying 375 employees in a Chinese high-risk… Continue reading Mapping the nomological network of employee self-determined safety motivation: A preliminary measure in China

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