Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Πέμπτη 26 Μαΐου 2016

OtoRhinoLaryngology & Medicine,New Articles,May 26th,2016,a


Lung Flooding Allows for Transthoracic Ultrasonographic Visualization of Endobronchial Forceps

Alexandros G. SfakianakisστοΝοσολογίαΠριν από 3 δευτερόλεπτα
[image: image]No abstract available from Respiratory via xlomafota13 on Inoreader http://ift.tt/1sc2zl2

Association between breast implants and the development of anaplastic large-cell lymphoma (ALCL)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Bacterial Biofilm Infection Detected in Breast Implant–Associated Anaplastic Large-Cell Lymphoma: [image: image]Background: A recent association between breast implants and the development of anaplastic large-cell lymphoma (ALCL) has been observed. The purpose of this study was to identify whether bacterial biofilm is present in breast implant–associated ALCL and, if so, to compare the bacterial microbiome to nontumor capsule samples from breast implants with contracture. Methods: Twenty-six breast implant–associated ALCL samples were analyzed for the presence of biofilm by real-tim... περισσότερα »

A Comparison of the Full and Short-Scar Face-Lift Incision Techniques

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
in Multiple Sets of Identical Twins: [image: image]Background: Choosing the ideal face-lift technique for a patient presents an added challenge for the plastic surgeon. With the multitude of well-established variations of this procedure, it would be beneficial to define which facioplasty technique produces the optimal result. By comparing the postoperative results from two of the most popularized face-lift incision techniques in monozygotic twins, it is hypothesized that the “best” technique may be determined. Methods: Four sets of identical twins and one set of identical triplets ... περισσότερα »

Keystone Perforator Island Flaps (KPIF)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Evolving Concepts of Keystone Perforator Island Flaps (KPIF): Principles of Perforator Anatomy, Design Modifications, and Extended Clinical Applications : [image: image]Background: Keystone flaps have demonstrated growing clinical applications in reconstructive surgery in the past decade. This article highlights flap modifications and their versatility for clinical applications and management of complex defects. Methods: A retrospective chart review was conducted of consecutive patients undergoing keystone flap reconstruction at the authors’ institution from January of 2012 to Dec... περισσότερα »

Superficial inferior epigastric artery (SIEA) and superficial circumflex iliac artery (SCIA) flaps

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Breast Reconstruction with SIEA Flaps: A Single-Institution Experience with 145 Free Flaps: Background: Refinements in microsurgical breast reconstruction have refined superficial inferior epigastric artery (SIEA) and superficial circumflex iliac artery (SCIA) flaps, yet technical difficulties and varied success rates limit widespread acceptance. The authors present the outcomes of their experience with 145 consecutive SIEA/SCIA flaps and suggest technical tips to improve success with this important flap. Methods: An institutional review board–approved retrospective chart review o... περισσότερα »

Unnecessary Emergency Transfers for Evaluation by a Plastic Surgeon

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
A Burden to Patients and the Health Care System: *[image: Collapse Box]*Author Information *Baltimore, Md.; and Providence and Wakefield, R.I.* *From the Department of Plastic Surgery, Johns Hopkins Medicine; the Departments of Plastic Surgery and Orthopaedic Surgery, Rhode Island Hospital and the Warren Alpert Medical School of Brown University; and South County Orthopedics.* *Received for publication September 10, 2015; accepted January 12, 2016.* *Presented at the Plastic Surgery The Meeting 2014: Annual Meeting of the American Society of Plastic Surgeons, in Chicago, Illinoi... περισσότερα »

Pharyngeal stability during sleep

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Dynamic comparison of pharyngeal stability during sleep in patients with obstructive sleep apnea syndrome treated with maxillomandibular advancement: Abstract PurposeTo compare the dynamic differences occurring in the pharynx during sleep after maxillomandibular advancement (MMA) surgery for the treatment of patients with obstructive sleep apnea syndrome. MethodsThis was a prospective, cross-sectional study conducted on 20 patients (15 men and 5 women) with a polysomnography diagnosis of obstructive sleep apnea (OSA) submitted to surgical treatment with MMA. All patients were ... περισσότερα »

IgE and mast cells in host defense against parasites and venoms

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
IgE and mast cells in host defense against parasites and venoms: AbstractIgE-dependent mast cell activation is a major effector mechanism underlying the pathology associated with allergic disorders. The most dramatic of these IgE-associated disorders is the fatal anaphylaxis which can occur in some people who have developed IgE antibodies to otherwise innocuous antigens, such as those contained in certain foods and medicines. Why would such a highly “maladaptive” immune response develop in evolution and be retained to the present day? Host defense against parasites has long been co... περισσότερα »

Pro- and anti-tumour effects of B cells and antibodies in cancer

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
a comparison of clinical studies and preclinical models: AbstractThe primary immune role of B cells is to produce antibodies, but they can also influence T cell function via antigen presentation and, in some contexts, immune regulation. Whether their roles in tumour immunity are similar to those in other chronic immune responses such as autoimmunity and chronic infection, where both pro- and anti-inflammatory roles have been described, remains controversial. Many studies have aimed to define the role of B cells in antitumor immune responses, but despite this considerable body of w...περισσότερα »

A new framework for the interpretation of IgE sensitization tests

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
A new framework for the interpretation of IgE sensitization tests: Abstract IgE sensitization tests, such as skin prick testing and serum specific IgE, have been used to diagnose IgE-mediated clinical allergy for many years. Their prime drawback is that they detect sensitization which is only loosely related to clinical allergy. Many patients therefore require provocation tests to make a definitive diagnosis; these are often expensive and potentially associated with severe reactions. The likelihood of clinical allergy can be semi-quantified from an IgE sensitization test results. T... περισσότερα »

Multiple water swallows and gastroesophageal reflux

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Relationship between multiple water swallows and gastroesophageal reflux in patients with normal esophageal motility.: [image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Choi YJ, Park MI, Park SJ, Moon W, Kim SE, Yoo CH, Kwon HJ Abstract Multiple water swallows (MWS) stimulates neural inhibition, resulting in abolition of contractions in the esophageal body and complete lower esophageal sphincter relaxation, which is followed by peristalsis and the lower esophageal sphincter contraction. We assessed the relationship between MWS and gastroesophageal reflux in patients with ... περισσότερα »

Catechol-O-methyl transferase (COMT) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and likelihood of symptomatic dysphagia in older people.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
A novel association between COMT and BDNF gene polymorphisms and likelihood of symptomatic dysphagia in older people.: [image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Nimmons D, Pendleton N, Payton A, Ollier W, Horan M, Wilkinson J, Hamdy S Abstract BACKGROUND: Catechol-O-methyl transferase (COMT) and brain-derived neurotrophic factor (BDNF) are neuro-modulatory proteins that have been demonstrated to affect cortical plasticity, which in turn has been shown to affect age-related changes and neuronal functioning in humans. Here, we tested the hypothesis that single nucl...περισσότερα »

High-resolution impedance manometry measurement of bolus flow time in achalasia and its correlation with dysphagia.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Lin Z, Carlson DA, Dykstra K, Sternbach J, Hungness E, Kahrilas PJ, Ciolino JD, Pandolfino JE Abstract BACKGROUND: We assessed whether a high-resolution impedance manometry (HRIM) metric, bolus flow time (BFT) across the esophagogastric junction (EGJ), was abnormal in achalasia patients subtyped by the Chicago Classification and compared BFT to other HRM metrics. METHODS: HRIM studies were performed in 60 achalasia patients (14 type I, 36 type II and 10 type III) and 15 healthy controls. Studies were analyzed with a MAT... περισσότερα »

Patients with refractory reflux symptoms often do not have GERD.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Herregods TV, Troelstra M, Weijenborg PW, Bredenoord AJ, Smout AJ Abstract BACKGROUND: In patients with typical reflux symptoms that persist despite proton pump inhibitors (PPIs) it is sometimes overlooked that treatment fails due to the presence of other disorders than gastroesophageal reflux disease (GERD). The aim of this study was to determine the underlying cause of reflux symptoms not responding to PPI therapy in tertiary referral patients. METHODS: Patients with reflux symptoms refractory to PPI therapy who under... περισσότερα »

Antireflux surgery on laryngeal symptoms, findings and voice parameters.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
The effect of antireflux surgery on laryngeal symptoms, findings and voice parameters.: [image: http:--production.springer.de-OnlineReso] Authors: Sahin M, Vardar R, Ersin S, Kirazli T, Ogut MF, Akyildiz NS, Bor S Abstract The aim of this study was to evaluate the effect of laparoscopic antireflux surgery (LARS) on the laryngeal symptoms, physical findings and voice parameters of gastroesophageal reflux disease (GERD) patients with or without laryngopharyngeal reflux (LPR). Forty-one GERD patients predominantly with LPR symptoms (Group I) and twenty-six GERD patients without LPR ... περισσότερα »

From refractory esophagitis to proton pump inhibitors (PPIs)-refractory symptoms

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
*Patients with refractory reflux symptoms: What do they have and how should they be managed?: * [image: http:--media.wiley.com-assets-7315-19-Wi] Authors: Kahrilas PJ, Keefer L, Pandolfino JE Abstract With the widespread use of proton pump inhibitors (PPIs), the frontier of treating reflux disease has shifted from refractory esophagitis to PPI-refractory symptoms. However, symptoms are inherently less specific than mucosal disease and, as noted by Herregods et al. in their contribution appearing in this issue of Neurogastroenterology and Motility, patients with refractory gastroes... περισσότερα »

Neurologic dysphagia

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
[Detection and management of the neurologic dysphagia].: Rev Med Suisse. 2016 ;12(508):467-71 Authors: Leemann B, Sergi S, Sahinpasic L, Schnider A Abstract Neurologic dysphagia is frequent and has consequences which can be severe, such as, denutrition andpneumonia. In most cases, it can be detected with a clinical exam. The management includes some general measures, an adaptation of textures, specific rehabilitation, and nutritional assessment to judge whether complementary enteral nutrition is needed. PMID: 27089605 [PubMed - indexed for MEDLINE]

Utility of up-front transoral robotic surgery in tailoring adjuvant therapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Utility of up-front transoral robotic surgery in tailoring adjuvant therapy: Abstract Background The purpose of this study was to describe how the up-front transoral robotic surgery (TORS) approach could be used to individually tailor adjuvant therapy based on surgical pathology. Methods Between January 2009 and December 2013, 76 patients received TORS for oropharyngeal squamous cell carcinoma (OPSCC). Clinical predictors of adjuvant therapy were analyzed and comparisons were made between recommended treatment guidelines for up-front surgery versus definitive nonsurgical appro...περισσότερα »

Social perception of morbidity in facial nerve paralysis

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Social perception of morbidity in facial nerve paralysis: ABSTRACT Background There are many patient-based and clinician-based scales measuring the severity of facial nerve paralysis and the impact on quality of life, however, the social perception of facial palsy has received little attention. The purpose of this pilot study was to measure the consequences of facial paralysis on selected domains of social perception and compare the social impact of paralysis of the different components. Method Four patients with typical facial palsies (global, marginal mandibular, zygomatic/bu... περισσότερα »

Primary tracheoesophageal puncture and cricopharyngeal myotomy in stapler-assisted total laryngectomy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Main ArticlePrimary tracheoesophageal puncture and cricopharyngeal myotomy in stapler-assisted total laryngectomyD M Beswicka1 and E J Damrosea1 c1 a1 Department of Otolaryngology / Head and Neck Surgery, Stanford University School of Medicine, California, USA Abstract Objective: To evaluate the utility of the hybrid tracheoesophageal puncture procedure in stapler-assisted laryngectomy. Methods: Patients who underwent total laryngectomy at a single institution from 2009 to 2015 were reviewed. The interventions assessed were surgical creation of a tracheoesophageal puncture and placem...περισσότερα »

Primary Refractory Angioimmunoblastic T-Cell Lymphoma

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Anti-CCR4 Monoclonal Antibody Mogamulizumab Followed by the GDP (Gemcitabine, Dexamethasone and Cisplatin) Regimen in Primary Refractory Angioimmunoblastic T-Cell Lymphoma: There are few effective options for salvage therapy in elderly patients with relapsed or refractory angioimmunoblastic T-cell lymphoma (AITL). The anti-CCR4 antibody mogamulizumab works via antibody-dependent cytotoxic activity, reduces regulatory T cells, and evokes antitumor immunity in cancer patients. We report a 78-year-old patient with refractory AITL receiving a new immunochemotherapy consisting of sequent... περισσότερα »

Chikungunya virus (CHIKV)

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection MBio. 2016;7(3) Authors: Ashbrook AW, Lentscher AJ, Zamora PF, Silva LA, May NA, Bauer JA, Morrison TE, Dermody TS Abstract UNLABELLED: Chikungunya virus (CHIKV) is a reemerging alphavirus that has caused epidemics of fever, arthralgia, and rash worldwide. There are currently no licensed vaccines or antiviral therapies available for the prevention or treatment of CHIKV disease. We conducted a high-throughput, chemical compound screen that identified digoxin, a cardiac glycoside that blocks the sodium-po... περισσότερα »

Stimulation of saliva flow by chewing gum could decrease mild to moderate inflammatory injuries of the oral mucosa during chemotherapy

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Effect of Chewing Gum on Oral Mucositis in Children Undergoing Chemotherapy: A Randomized Controlled Study.: Iran J Ped Hematol Oncol. 2016;6(1):9-14 Authors: Eghbali A, Taherkhanchi B, Bagheri B, Sadeghi Sedeh B Abstract BACKGROUND: Oral mucositis is an adverse effect of chemotherapy. Type of chemotherapy regimen is the most important factor causing mucositis. Oral mucositis is usually associated with transient decrease in saliva production. The goal was to study effects of gum consumption on oral mucositis in children undergoing chemotherapy. MATERIALS AND METHOD: This randomize... περισσότερα »

Malignant Peripheral Nerve Sheath Tumor of the Jugular Foramen.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Malignant Peripheral Nerve Sheath Tumor of the Jugular Foramen.:

Sudden Pediatric Hearing Loss: Combined Treatment (Intratympanic Dexamethasone and Systemic Steroids) With Systemic Steroid Treatment Alone.

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Sudden Pediatric Hearing Loss: Comparing the Results of Combined Treatment (Intratympanic Dexamethasone and Systemic Steroids) With Systemic Steroid Treatment Alone.: Objective: The aim of the present study was to compare hearing improvements obtained with combined intratympanic and systemic steroid therapy, and systemic steroid therapy alone in pediatric patients with idiopathic sudden sensorineural hearing loss (SSHL). Study Design: Retrospective. Setting: Tertiary referral hospital. Patients: Pediatric patients with SSHL. Interventions: The patients were divided into two groups,...περισσότερα »

Subcutaneous Piezoelectrically Actuated Hearing Aid

Alexandros G. SfakianakisστοOtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Functional Testing of Subcutaneous Piezoelectrically Actuated Hearing Aid: Comparison With BAHA and Potential for Treating Single-sided Deafness.: Objective: To compare the performance of a subcutaneous piezoelectrically actuated hearing aid (SPAHA) with the bone-anchored hearing aid (BAHA) and assess its effectiveness as a treatment option for conductive loss and single-sided deafness (SSD). Background: To validate the use of the SPAHA as a bone conduction implant, its performance was compared with a widely used bone conduction implant, the BAHA. Maximum dynamic range, power consum... περισσότερα »

Nursing Interventions for Identifying and Managing Acute Dysphagia are Effective for Improving Patient Outcomes: A Systematic Review Update.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
*Nursing Interventions for Identifying and Managing Acute Dysphagia are Effective for Improving Patient Outcomes: A Systematic Review Update.* J Neurosci Nurs. 2016 May 24; Authors: Hines S, Kynoch K, Munday J Abstract BACKGROUND: Dysphagia, or difficulty in swallowing, is a serious and life-threatening medical condition that affects a significant number of individuals with acute neurological impairment, largely from stroke. Dysphagia is not generally considered a major cause of mortality; however, the complications that result from this medical condition, namely, aspiration pneu... περισσότερα »

Chronic Myopathy Associated With Anti-Signal Recognition Particle Antibodies Can Be Misdiagnosed As Facioscapulohumeral Muscular Dystrophy.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
*Chronic Myopathy Associated With Anti-Signal Recognition Particle Antibodies Can Be Misdiagnosed As Facioscapulohumeral Muscular Dystrophy.* J Clin Neuromuscul Dis. 2016 Jun;17(4):197-206 Authors: Ikeda K, Mori-Yoshimura M, Yamamoto T, Sonoo M, Suzuki S, Kondo Y, Nakamura H, Mitsuhashi K, Maeda MH, Shimizu J, Hayashi YK, Nishino I, Oya Y, Murata M Abstract OBJECTIVES: To report cases of chronic autoimmune necrotizing myopathy with anti-signal recognition particle antibodies (anti-SRP myopathy) initially misdiagnosed as muscular dystrophy, in particular, facioscapulohumeral muscu... περισσότερα »

The safety and efficacy of endoscopic Zenker's diverticulotomy: A cohort study.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
*The safety and efficacy of endoscopic Zenker's diverticulotomy: A cohort study.* Laryngoscope. 2016 May 25; Authors: Barton MD, Detwiller KY, Palmer AD, Schindler JS Abstract OBJECTIVES/HYPOTHESIS: To determine whether the application of laser-assisted techniques for the treatment of Zenker's diverticulum would reduce the failure rate of endoscopic procedures without compromising safety or durability. STUDY DESIGN: Cohort study with long-term follow-up. METHODS: We performed a single-institution review of 106 consecutive patients in whom endoscopic laser-assisted diverticulotomy ...περισσότερα »

Management of an elderly patient with respiratory failure due to double aortic arch.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
*Management of an elderly patient with respiratory failure due to double aortic arch.* Respir Med Case Rep. 2016;17:37-9 Authors: Ryu C, Puchalski J, Perkins M, Honiden S Abstract Vascular rings are congenital malformations of the aortic arch. A double aortic arch (DAA), the most common type of vascular ring, results from the failure of the fourth embryonic branchial arch to regress, leading to an ascending aorta that divides into a left and right arch that fuse together to completely encircle the trachea and esophagus. The subsequent DAA causes compressive effects on the trachea... περισσότερα »

Transoral robotic surgery for the management of obstructive sleep apnea: a systematic review and meta-analysis.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
*Transoral robotic surgery for the management of obstructive sleep apnea: a systematic review and meta-analysis.* Eur Arch Otorhinolaryngol. 2016 May 24; Authors: Meccariello G, Cammaroto G, Montevecchi F, Hoff PT, Spector ME, Negm H, Shams M, Bellini C, Zeccardo E, Vicini C Abstract Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a serious social health problem with significant implications on quality of life. Surgery for OSAHS has been criticized due to a lack of evidence to support its efficacy as well as the heterogeneous reporting of published outcomes. Moreover, the tr...περισσότερα »

A case of simultaneous esophageal squamous cell carcinoma and Barrett's adenocarcinoma.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
*A case of simultaneous esophageal squamous cell carcinoma and Barrett's adenocarcinoma.* Clin J Gastroenterol. 2016 May 25; Authors: Yamazaki T, Iwaya Y, Iwaya M, Watanabe T, Seki A, Ochi Y, Hara E, Sekiguchi T, Hosaka N, Arakura N, Tanaka E, Hasebe O Abstract A 77-year-old male with a long history of alcohol consumption and smoking was admitted for hoarseness and dysphagia. Computed tomography revealed thickening of the middle intrathoracic esophageal wall and multiple mediastinal lymph node swellings. Esophagogastroduodenoscopic examination disclosed an advanced-stage squamous... περισσότερα »

PHARMACOLOGICAL TREATMENT OF CHILDREN WITH GASTRO-ESOPHAGEAL REFLUX: A SUMMARY.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *PHARMACOLOGICAL TREATMENT OF CHILDREN WITH GASTRO-ESOPHAGEAL REFLUX: A SUMMARY.* Gastroenterol Nurs. 2016 Jan-Feb;39(1):68-70 Authors: Gaines C PMID: 26825568 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1TGalMX

Patients with refractory reflux symptoms: What do they have and how should they be managed?

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Patients with refractory reflux symptoms: What do they have and how should they be managed?* Neurogastroenterol Motil. 2015 Sep;27(9):1195-201 Authors: Kahrilas PJ, Keefer L, Pandolfino JE Abstract With the widespread use of proton pump inhibitors (PPIs), the frontier of treating reflux disease has shifted from refractory esophagitis to PPI-refractory symptoms. However, symptoms are inherently less specific than mucosal disease and, as noted by Herregods et al. in their contribution appearing in this issue of Neur... περισσότερα »

Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non-fibrotic disease among pre-lung transplant patients.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non-fibrotic disease among pre-lung transplant patients.* Neurogastroenterol Motil. 2015 Sep;27(9):1326-32 Authors: Gavini S, Finn RT, Lo WK, Goldberg HJ, Burakoff R, Feldman N, Chan WW Abstract BACKGROUND: Gastroesophageal reflux (GER) has been associated with idiopathic pulmonary fibrosis (IPF), although the mechanism remains unclear. Gastroesophageal reflux/microaspiration may lead to lung fibrosis, while increa...περισσότερα »

The effect of antireflux surgery on laryngeal symptoms, findings and voice parameters.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--production.springer.de-OnlineReso] Related Articles *The effect of antireflux surgery on laryngeal symptoms, findings and voice parameters.* Eur Arch Otorhinolaryngol. 2015 Nov;272(11):3375-83 Authors: Sahin M, Vardar R, Ersin S, Kirazli T, Ogut MF, Akyildiz NS, Bor S Abstract The aim of this study was to evaluate the effect of laparoscopic antireflux surgery (LARS) on the laryngeal symptoms, physical findings and voice parameters of gastroesophageal reflux disease (GERD) patients with or without laryngopharyngeal reflux (LPR). Forty-one GERD patients predominantly ... περισσότερα »

Patients with refractory reflux symptoms often do not have GERD.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Patients with refractory reflux symptoms often do not have GERD.* Neurogastroenterol Motil. 2015 Sep;27(9):1267-73 Authors: Herregods TV, Troelstra M, Weijenborg PW, Bredenoord AJ, Smout AJ Abstract BACKGROUND: In patients with typical reflux symptoms that persist despite proton pump inhibitors (PPIs) it is sometimes overlooked that treatment fails due to the presence of other disorders than gastroesophageal reflux disease (GERD). The aim of this study was to determine the underlying cause of reflux symptoms not re... περισσότερα »

Reduction of hydrogen sulfide synthesis enzymes in the esophagus of patients with achalasia: effect of hydrogen sulfide in achalasia.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Reduction of hydrogen sulfide synthesis enzymes in the esophagus of patients with achalasia: effect of hydrogen sulfide in achalasia.* Neurogastroenterol Motil. 2015 Sep;27(9):1274-81 Authors: Zhang L, Zhao W, Zheng Z, Wang T, Zhao C, Zhou G, Jin H, Wang B Abstract BACKGROUND: The aim of the present study was to investigate whether the synthesis of endogenous hydrogen sulfide (H2 S) was altered in achalasia patients and to determine the effects of H2 S on esophageal motility. METHODS: (1) Tissue samples in lower eso... περισσότερα »

Pathophysiology of gastroesophageal reflux disease: new understanding in a new era.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Pathophysiology of gastroesophageal reflux disease: new understanding in a new era.* Neurogastroenterol Motil. 2015 Sep;27(9):1202-13 Authors: Herregods TV, Bredenoord AJ, Smout AJ Abstract BACKGROUND: The prevalence of gastroesophageal reflux disease (GERD) has increased in the last decades and it is now one of the most common chronic diseases. Throughout time our insight in the pathophysiology of GERD has been characterized by remarkable back and forth swings, often prompted by new investigational techniques. Ev... περισσότερα »

Diagnostic value of dilated intercellular space and histopathologic scores in gastroesophageal reflux disease.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Diagnostic value of dilated intercellular space and histopathologic scores in gastroesophageal reflux disease.* Dis Esophagus. 2015 Aug-Sep;28(6):530-7 Authors: Cui R, Zhang H, Zhou L, Lu J, Xue Y, Wang Y, Yan X, Lin L, Lin S Abstract The aim of this paper is to investigate the diagnostic value of histopathologic score and the dilated intercellular space (DIS) in patients with gastroesophageal reflux disease (GERD) and functional heartburn (FH). Participants with GERD symptoms including reflux esophagitis, non-eros... περισσότερα »

Relationship between multiple water swallows and gastroesophageal reflux in patients with normal esophageal motility.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Relationship between multiple water swallows and gastroesophageal reflux in patients with normal esophageal motility.* Dis Esophagus. 2015 Aug-Sep;28(6):520-3 Authors: Choi YJ, Park MI, Park SJ, Moon W, Kim SE, Yoo CH, Kwon HJ Abstract Multiple water swallows (MWS) stimulates neural inhibition, resulting in abolition of contractions in the esophageal body and complete lower esophageal sphincter relaxation, which is followed by peristalsis and the lower esophageal sphincter contraction. We assessed the relationship ... περισσότερα »

Activity of mitogen-activated protein kinases in the esophageal epithelium of patients with Barrett's esophagus.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Activity of mitogen-activated protein kinases in the esophageal epithelium of patients with Barrett's esophagus.* Dis Esophagus. 2015 Aug-Sep;28(6):585-92 Authors: Chwiesko A, Baniukiewicz A, Semeniuk J, Kaczmarski M, Wasielica-Berger J, Milewski R, Dabrowski A Abstract Barrett's esophagus (BE), a complication of gastroesophageal reflux disease, is associated with an increased risk of esophageal cancer. Mitogen-activated protein kinases may play an important role in the pathogenesis of this process. We aimed to ev... περισσότερα »

Esophageal mucosal mast cell infiltration and changes in segmental smooth muscle contraction in noncardiac chest pain.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Esophageal mucosal mast cell infiltration and changes in segmental smooth muscle contraction in noncardiac chest pain.* Dis Esophagus. 2015 Aug-Sep;28(6):512-9 Authors: Park SW, Lee H, Lee HJ, Chung H, Park JC, Shin SK, Lee SK, Lee YC Abstract Mast cells release potent mediators that alter enteric nerve and smooth muscle functions and may contribute to the pathogenesis of functional gastrointestinal disorders. The goal of this study was to determine if mucosal mast cell infiltration was associated with smooth muscl... περισσότερα »

[Detection and management of the neurologic dysphagia].

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
Related Articles *[Detection and management of the neurologic dysphagia].* Rev Med Suisse. 2016 Mar 2;12(508):467-71 Authors: Leemann B, Sergi S, Sahinpasic L, Schnider A Abstract Neurologic dysphagia is frequent and has consequences which can be severe, such as, denutrition andpneumonia. In most cases, it can be detected with a clinical exam. The management includes some general measures, an adaptation of textures, specific rehabilitation, and nutritional assessment to judge whether complementary enteral nutrition is needed. PMID: 27089605 [PubMed - indexed for MEDLINE] from Sw...περισσότερα »

PHARMACOLOGICAL TREATMENT OF CHILDREN WITH GASTRO-ESOPHAGEAL REFLUX: A SUMMARY.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--pt.wkhealth.com-pt-pt-core-templa] Related Articles *PHARMACOLOGICAL TREATMENT OF CHILDREN WITH GASTRO-ESOPHAGEAL REFLUX: A SUMMARY.* Gastroenterol Nurs. 2016 Jan-Feb;39(1):68-70 Authors: Gaines C PMID: 26825568 [PubMed - indexed for MEDLINE] from Swallowing and Swallowing Disorders (Dysphagia) via xlomafota13 on Inoreader http://ift.tt/1TGalMX

Patients with refractory reflux symptoms: What do they have and how should they be managed?

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Patients with refractory reflux symptoms: What do they have and how should they be managed?* Neurogastroenterol Motil. 2015 Sep;27(9):1195-201 Authors: Kahrilas PJ, Keefer L, Pandolfino JE Abstract With the widespread use of proton pump inhibitors (PPIs), the frontier of treating reflux disease has shifted from refractory esophagitis to PPI-refractory symptoms. However, symptoms are inherently less specific than mucosal disease and, as noted by Herregods et al. in their contribution appearing in this issue of Neur... περισσότερα »

Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non-fibrotic disease among pre-lung transplant patients.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Idiopathic pulmonary fibrosis is associated with increased impedance measures of reflux compared to non-fibrotic disease among pre-lung transplant patients.* Neurogastroenterol Motil. 2015 Sep;27(9):1326-32 Authors: Gavini S, Finn RT, Lo WK, Goldberg HJ, Burakoff R, Feldman N, Chan WW Abstract BACKGROUND: Gastroesophageal reflux (GER) has been associated with idiopathic pulmonary fibrosis (IPF), although the mechanism remains unclear. Gastroesophageal reflux/microaspiration may lead to lung fibrosis, while increa...περισσότερα »

The effect of antireflux surgery on laryngeal symptoms, findings and voice parameters.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--production.springer.de-OnlineReso] Related Articles *The effect of antireflux surgery on laryngeal symptoms, findings and voice parameters.* Eur Arch Otorhinolaryngol. 2015 Nov;272(11):3375-83 Authors: Sahin M, Vardar R, Ersin S, Kirazli T, Ogut MF, Akyildiz NS, Bor S Abstract The aim of this study was to evaluate the effect of laparoscopic antireflux surgery (LARS) on the laryngeal symptoms, physical findings and voice parameters of gastroesophageal reflux disease (GERD) patients with or without laryngopharyngeal reflux (LPR). Forty-one GERD patients predominantly ... περισσότερα »

Patients with refractory reflux symptoms often do not have GERD.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Patients with refractory reflux symptoms often do not have GERD.* Neurogastroenterol Motil. 2015 Sep;27(9):1267-73 Authors: Herregods TV, Troelstra M, Weijenborg PW, Bredenoord AJ, Smout AJ Abstract BACKGROUND: In patients with typical reflux symptoms that persist despite proton pump inhibitors (PPIs) it is sometimes overlooked that treatment fails due to the presence of other disorders than gastroesophageal reflux disease (GERD). The aim of this study was to determine the underlying cause of reflux symptoms not re... περισσότερα »

High-resolution impedance manometry measurement of bolus flow time in achalasia and its correlation with dysphagia.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *High-resolution impedance manometry measurement of bolus flow time in achalasia and its correlation with dysphagia.* Neurogastroenterol Motil. 2015 Sep;27(9):1232-8 Authors: Lin Z, Carlson DA, Dykstra K, Sternbach J, Hungness E, Kahrilas PJ, Ciolino JD, Pandolfino JE Abstract BACKGROUND: We assessed whether a high-resolution impedance manometry (HRIM) metric, bolus flow time (BFT) across the esophagogastric junction (EGJ), was abnormal in achalasia patients subtyped by the Chicago Classification and compared BFT t...περισσότερα »

Reduction of hydrogen sulfide synthesis enzymes in the esophagus of patients with achalasia: effect of hydrogen sulfide in achalasia.

Alexandros G. SfakianakisστοSwallowing and Swallowing Disorders (Dysphagia)Πριν από 24 δευτερόλεπτα
[image: http:--media.wiley.com-assets-7315-19-Wi] Related Articles *Reduction of hydrogen sulfide synthesis enzymes in the esophagus of patients with achalasia: effect of hydrogen sulfide in achalasia.* Neurogastroenterol Motil. 2015 Sep;27(9):1274-81 Authors: Zhang L, Zhao W, Zheng Z, Wang T, Zhao C, Zhou G, Jin H, Wang B Abstract BACKGROUND: The aim of the present study was to investigate whether the synthesis of endogenous hydrogen sulfide (H2 S) was altered in achalasia patients and to determine the effects of H2 S on esophageal motility. METHODS: (1) Tissue samples in lower eso... περισσότερα »

Personal music systems and hearing.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*Personal music systems and hearing.* J Laryngol Otol. 2016 May 25;:1-13 Authors: Kumar UA, Deepashree SR Abstract OBJECTIVES: To measure the output sound pressure levels of personal music systems and evaluate their effect on hearing. METHODS: Output sound pressure levels at preferred volume settings and listening environment were measured using a manikin. Effects of personal music system use on hearing were evaluated using pure tone audiometry (in conventional and extended high frequency ranges), transient evoked otoacoustic emissions, syllable identification in noise, intensity ...περισσότερα »

[Detection and management of the neurologic dysphagia].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
Related Articles *[Detection and management of the neurologic dysphagia].* Rev Med Suisse. 2016 Mar 2;12(508):467-71 Authors: Leemann B, Sergi S, Sahinpasic L, Schnider A Abstract Neurologic dysphagia is frequent and has consequences which can be severe, such as, denutrition andpneumonia. In most cases, it can be detected with a clinical exam. The management includes some general measures, an adaptation of textures, specific rehabilitation, and nutritional assessment to judge whether complementary enteral nutrition is needed. PMID: 27089605 [PubMed - indexed for MEDLINE] from #...περισσότερα »

Does clinician continuity influence hearing aid outcomes?

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*Does clinician continuity influence hearing aid outcomes?* Int J Audiol. 2016 May 25;:1-8 Authors: Bennett RJ, Meyer C, Eikelboom RH Abstract OBJECTIVE: To evaluate whether clinician continuity is associated with successful hearing aid outcomes. DESIGN: A prospective cohort study. Clinician continuity was defined as occurring when a patient was cared for by the same clinician for the hearing assessment, hearing aid selection process, hearing aid fitting and programming, and subsequent hearing aid fine tuning appointments. The hearing aid outcome measures included self-reported he...περισσότερα »

Book Review.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*Book Review.* Int J Audiol. 2016 May 25;:1 Authors: Baguley DM, Fagelson M PMID: 27223682 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1qLcSLv via IFTTT

Prognostic and Evolutive Factors of Tinnitus Triggered by Sudden Sensorineural Hearing Loss.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*Prognostic and Evolutive Factors of Tinnitus Triggered by Sudden Sensorineural Hearing Loss.* Otol Neurotol. 2016 May 24; Authors: Nogueira-Neto FB, Gallardo FP, Suzuki FA, Penido NO Abstract INTRODUCTION: The association between sudden sensorineural hearing loss (SSNHL) and tinnitus is frequent. Its correlation with the auditory prognosis remains controversial. The objective of the study is to evaluate tinnitus of which onset is concurrent with SSNHL and analyze it as a prognostic factor and its correlation with hearing recovery. MATERIALS AND METHODS: A prospective cohort study...περισσότερα »

Association of Vogt Koyanagi Harada Syndrome and Seronegative Rheumatoid Arthritis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*Association of Vogt Koyanagi Harada Syndrome and Seronegative Rheumatoid Arthritis.* Ethiop J Health Sci. 2016 Mar;26(2):193-6 Authors: Aydin T, Taspinar O, Guneser M, Keskin Y Abstract BACKGROUND: Vogt Koyanagi Harada (VKH) Syndrome is a rarely-seen multi-systemic, autoimmune and inflammatory disease. It observed frequently with neurologic, auditory and skin manifestations and characterized with bilateral, chronic and diffused granulomatous panuveitis. It generally affects women in young-adult period. CASE: A 57 year-old female patient applied to a special center one year ago w... περισσότερα »

[The clinical experience of transnasal endoscopic approach for skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*[The clinical experience of transnasal endoscopic approach for skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 May 7;51(5):367-71 Authors: Lan GP, Huang B, Si YF, Qin YD, Deng ZX, Yang Y, Qin Y, Zhang BJ Abstract OBJECTIVE: To investigate the method of surgical treatment via trans-nasal endoscopic approach in osteoradionecrosis of skull base after radiotherapy for nasopharyngeal carcinoma. METHODS: Fifteen patients with osteoradionecrosis of skull base after radiotherapy for nasopharyngeal carcino... περισσότερα »

Tympanic membrane perforation with squamous epithelial ingrowth.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
Related Articles *Tympanic membrane perforation with squamous epithelial ingrowth.* Ear Nose Throat J. 2014 Aug;93(8):E31-2 Authors: Blake DM, Vazquez A, Tomovic S, Jyung RW Abstract The squamous epithelium of the tympanic membrane and external auditory canal exhibits an inherent migration pattern to facilitate the exfoliation of keratinizing squamous cells as part of a natural cleansing mechanism. PMID: 25181673 [PubMed - indexed for MEDLINE] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1WlB5Gb via IFTTT

"Gan To Kagaku Ryoho"[jour]; +20 new citations

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
20 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: *"Gan To Kagaku Ryoho"[jour]* These pubmed results were generated on 2016/05/26 PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1OOYpEp via IFTTT

Evaluation of type II thyroplasty on phonatory physiology in an excised canine larynx model.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*Evaluation of type II thyroplasty on phonatory physiology in an excised canine larynx model.* Laryngoscope. 2016 May 25; Authors: Devine EE, Hoffman MR, McCulloch TM, Jiang JJ Abstract OBJECTIVES/HYPOTHESIS: Type II thyroplasty is an alternative treatment for spasmodic dysphonia, addressing hyperadduction by incising and lateralizing the thyroid cartilage. We quantified the effect of lateralization width on phonatory physiology using excised canine larynges. METHODS: Normal closure, hyperadduction, and type II thyroplasty (lateralized up to 5 mm at 1-mm increments with hyperadduc...περισσότερα »

Virtual Screening Approaches in Identification of Bioactive Compounds Akin to Delphinidin as Potential HER2 Inhibitors for the Treatment of Breast Cancer.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*Virtual Screening Approaches in Identification of Bioactive Compounds Akin to Delphinidin as Potential HER2 Inhibitors for the Treatment of Breast Cancer.* Asian Pac J Cancer Prev. 2016;17(4):2291-5 Authors: Patidar K, Deshmukh A, Bandaru S, Lakkaraju C, Girdhar A, Vr G, Banerjee T, Nayarisseri A, Singh SK Abstract Small molecule tyrosine kinase inhibitors targeting HER 2 receptors have emerged as an important therapeutic approach in inhibition of downstream proliferation and survival signals for the treatment of breast cancers. Recent drug discovery efforts have demonstrated th... περισσότερα »

Arytenoid cartilage chondroma.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
Related Articles *Arytenoid cartilage chondroma.* Ear Nose Throat J. 2014 Aug;93(8):298 Authors: Portnoy JE, Sataloff JB, Hawkshaw MJ, Sataloff RT PMID: 25181657 [PubMed - indexed for MEDLINE] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/25nuJLC via IFTTT

Lateral Skull Base Attenuation in Superior Semicircular Canal Dehiscence and Spontaneous Cerebrospinal Fluid Otorrhea.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 37 δευτερόλεπτα
*Lateral Skull Base Attenuation in Superior Semicircular Canal Dehiscence and Spontaneous Cerebrospinal Fluid Otorrhea.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Rizk HG, Hatch JL, Stevens SM, Lambert PR, Meyer TA Abstract OBJECTIVES: (1) To quantitatively assess the lateral skull base thickness in patients with superior semicircular canal dehiscense (SSCD) using a standardized and validated radiographic measure and to compare it with that of a population with spontaneous cerebrospinal fluid otorrhea (CSFO). (2) To analyze demographic and clinical factors associated with ...περισσότερα »

Does clinician continuity influence hearing aid outcomes?

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
*Does clinician continuity influence hearing aid outcomes?* Int J Audiol. 2016 May 25;:1-8 Authors: Bennett RJ, Meyer C, Eikelboom RH Abstract OBJECTIVE: To evaluate whether clinician continuity is associated with successful hearing aid outcomes. DESIGN: A prospective cohort study. Clinician continuity was defined as occurring when a patient was cared for by the same clinician for the hearing assessment, hearing aid selection process, hearing aid fitting and programming, and subsequent hearing aid fine tuning appointments. The hearing aid outcome measures included self-reported he...περισσότερα »

Book Review.

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
*Book Review.* Int J Audiol. 2016 May 25;:1 Authors: Baguley DM, Fagelson M PMID: 27223682 [PubMed - as supplied by publisher] from #Audiology via ola Kala on Inoreader http://ift.tt/1qLcSLv via IFTTT

Does clinician continuity influence hearing aid outcomes?

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
*Does clinician continuity influence hearing aid outcomes?* Int J Audiol. 2016 May 25;:1-8 Authors: Bennett RJ, Meyer C, Eikelboom RH Abstract OBJECTIVE: To evaluate whether clinician continuity is associated with successful hearing aid outcomes. DESIGN: A prospective cohort study. Clinician continuity was defined as occurring when a patient was cared for by the same clinician for the hearing assessment, hearing aid selection process, hearing aid fitting and programming, and subsequent hearing aid fine tuning appointments. The hearing aid outcome measures included self-reported he...περισσότερα »

Book Review.

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
*Book Review.* Int J Audiol. 2016 May 25;:1 Authors: Baguley DM, Fagelson M PMID: 27223682 [PubMed - as supplied by publisher] from #Audiology via ola Kala on Inoreader http://ift.tt/1qLcSLv via IFTTT

Deaf Adolescents' Learning of Cardiovascular Health Information: Sources and Access Challenges.

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
[image: http:--highwire.stanford.edu-icons-exter] Related Articles *Deaf Adolescents' Learning of Cardiovascular Health Information: Sources and Access Challenges.* J Deaf Stud Deaf Educ. 2015 Oct;20(4):408-18 Authors: Smith SR, Kushalnagar P, Hauser PC Abstract Deaf individuals have more cardiovascular risks than the general population that are believed to be related to their cardiovascular health knowledge disparities. This phenomenological study describes where 20 deaf sign language-using adolescents from Rochester, New York, many who possess many positive characteristics to su... περισσότερα »

Does clinician continuity influence hearing aid outcomes?

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
10.1080/14992027.2016.1185169<br>Rebecca J. Bennett from #Audiology via ola Kala on Inoreader http://ift.tt/248WKAz via IFTTT

Book Review

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
10.1080/14992027.2016.1183826<br>David M. Baguley from #Audiology via ola Kala on Inoreader http://ift.tt/1RsON22 via IFTTT

Does clinician continuity influence hearing aid outcomes?

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
10.1080/14992027.2016.1185169<br>Rebecca J. Bennett from #Audiology via ola Kala on Inoreader http://ift.tt/248WKAz via IFTTT

Book Review

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 44 δευτερόλεπτα
10.1080/14992027.2016.1183826<br>David M. Baguley from #Audiology via ola Kala on Inoreader http://ift.tt/1RsON22 via IFTTT

Shine bright or live long: substituent effects in Cu(N^N)(P^P)+-based light-emitting electrochemical cells where N^N is a 6-substituted 2,2′-bipyridine

We report [Cu(P^P)(N^N)][PF6] complexes with P^P = bis(2-(diphenylphosphino)phenyl)ether (POP) or 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (xantphos) and N^N = 6-methyl-2,2′-bipyridine (Mebpy), 6-ethyl-2,2′-bipyridine (Etbpy), 6,6′-dimethyl-2,2′-bipyridine (Me2bpy) or 6-phenyl-2,2′-bipyridine (Phbpy). The crystal structures of [Cu(POP)(Phbpy)][PF6]·Et2O, [Cu(POP)(Etbpy)][PF6]·Et2O, [Cu(xantphos)(Me2bpy)][PF6], [Cu(xantphos)(Mebpy)][PF6]·CH2Cl2·0.4Et2O, [Cu(xantphos)(Etbpy)][PF6]·CH2Cl2·1.5H2O and [Cu(xantphos)(Phbpy)][PF6] are described; each copper(I) centre is distorted te... περισσότερα »

Dr Kenneth Anderson explains the treatment of relapsed myeloma with novel targeted and immune therapies: https://t.co/LBjm8iByc9

Dr Kenneth Anderson explains the treatment of relapsed myeloma with novel targeted and immune therapies: https://t.co/LBjm8iByc9 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/735780139926052864 via IFTTT

Read the research on the link betwen #prostate cancer biopsies and erectile dysfunction: https://t.co/55DoVpIWjD https://t.co/GynRq9rS0V

Read the research on the link betwen #prostate cancer biopsies and erectile dysfunction: https://t.co/55DoVpIWjD https://t.co/GynRq9rS0V from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/735777527164063748 via IFTTT

Molecular mechanism for repairing DNA damage by radiation clarified https://t.co/MYRSXpXPqy https://t.co/kj34UtWG92

Molecular mechanism for repairing DNA damage by radiation clarified https://t.co/MYRSXpXPqy https://t.co/kj34UtWG92 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/735773757961183232 via IFTTT

Global economic crisis linked to over 260,000 additional cancer deaths, according to new Lancet study: https://t.co/zsKbkPUKx5

Global economic crisis linked to over 260,000 additional cancer deaths, according to new Lancet study: https://t.co/zsKbkPUKx5 from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://twitter.com/ecancer/status/735769976309567489 via IFTTT

Clinical effects in resection of congenital choledochal cyst of children and jejunum Roux-Y anastomosis by laparoscope

OBJECTIVE: We compared the effects and complications in resection of the congenital choledochal cyst (CCC) and hepatic duct jejunum Roux-Y anastomosis by laparoscope and open surgery. PATIENTS AND METHODS: We continuously selected 156 cases of pediatric patients with CCC, which were divided into 70 cases of the laparoscopic group and 86 cases of laparotomy group […]

Comparative proteomic analysis of membrane microdomains isolated from two hyperlipidemic animal models

Publication date: Available online 26 May 2016 Source:Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics Author(s): Viorel-Iulian Suica, Elena Uyy, Raluca Maria Boteanu, Luminita Ivan, Felicia Antohe from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20FHIS9 via IFTTT

World No Tobacco 2016 all’Istituto Nazionale dei Tumori

World No Tobacco Day all’Istituto Nazionale dei Tumori Martedì 31 maggio 2016 — Ore 9.30 – 13.00 Aula Magna – Ingresso libero Fondazione IRCCS Istituto Nazionale dei Tumori Via G. Venezian, 1 – 20133, Milano from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1scdATp via IFTTT

Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement.

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
*Sampling and Definitions of Placental Lesions: Amsterdam Placental Workshop Group Consensus Statement.* Arch Pathol Lab Med. 2016 May 25; Authors: Khong TY, Mooney EE, Ariel I, Balmus NC, Boyd TK, Brundler MA, Derricott H, Evans MJ, Faye-Petersen OM, Gillan JE, Heazell AE, Heller DS, Jacques SM, Keating S, Kelehan P, Maes A, McKay EM, Morgan TK, Nikkels PG, Parks WT, Redline RW, Scheimberg I, Schoots MH, Sebire NJ, Timmer A, Turowski G, van der Voorn JP, van Lijnschoten I, Gordijn SJ Abstract Context .- The value of placental examination in investigations of adverse pregnancy ou... περισσότερα »

PRELIM II(EDI BOARD)

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: alertIcon.gif] Publication date: June 2016 *Source:*Neuroscience Research, Volume 107 from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1WVOHs8 via IFTTT

On-Treatment Elevation in Hepatic Transaminases during HCV Treatment with Ombitasvir, Paritaprevir, Dasabuvir, Ritonavir, and Ribavirin: A Case Series

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Eradication of chronic hepatitis C virus (HCV) infection is now possible with all oral antiviral medications, including the combination of ombitasvir, paritaprevir, dasabuvir, and ritonavir (PrOD) with or without ribavirin. While high rates of sustained virologic response (SVR) can be achieved, a small subset of patients experience on-treatment liver enzyme elevations, in particular women using concurrent estradiol-containing oral contraceptive medications (OCPs). Herein, we describe four cases of liver enzyme elevations within 2-3 weeks of PrOD initiation in African-American men in... περισσότερα »

Monoscopic photogrammetry to obtain 3D models by a mobile device: a method for making facial prostheses

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
The aim of this study is to present the development of a new technique to obtain 3D models using photogrammetry by a mobile device and free software, as a method for making digital facial impressions of patien... from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1WlrWxf via IFTTT

Regulation of the Inflammasomes by Autophagy

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
Publication date: Available online 24 May 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Tatsuya Saitoh, Shizuo Akira Inflammasomes detect pathogen-associated molecular patterns to induce inflammatory innate immune responses and play a key role in host defense against infectious agents. However, inflammasomes are often wrongly activated by metabolites, amyloids, and environmental irritants. This induces massive inflammation, causing severe tissue damage and results in the development of inflammatory diseases. Hence, cellular machineries regulating both “activation...περισσότερα »

Cellular Blue Nevus Diagnosed following Excision of Melanoma: A Challenge in Diagnosis

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
A case of a 41-year-old woman with a history of nodular melanoma (NM), associated with an indurated dome-shaped blue-black nodule with a diameter of 1.2 cm in the gluteal region, is presented. Clinical diagnosis of the lesion, present from birth, was blue nevus. Recently, the nodule has been showing a mild enlargement and thus complete resection was performed. Histological analysis revealed a pigmented lesion with an expansive pattern of extension into the dermis and the subcutaneous adipose tissue. The lesion displayed an alveolar pattern as well as a pigmented dendritic cell patte...περισσότερα »

Reply: Dynamics of Gluteal Cleft Morphology in Lower Body Lift: Predictors of Unfavorable Outcomes

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1TFWciM via IFTTT

Discussion: Bacterial Biofilm Infection Detected in Breast Implant–Associated Anaplastic Large-Cell Lymphoma

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/27TsRcm via IFTTT

Unnecessary Emergency Transfers for Evaluation by a Plastic Surgeon: A Burden to Patients and the Health Care System

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: Plastic surgeons are frequently consulted for hand and facial injuries, and patients are often transferred to trauma centers for evaluation of these problems. The authors sought to identify the frequency and impact of “unnecessary” transfers for emergency evaluation by a plastic surgeon at a Level I trauma center. Methods: The authors reviewed more than 32,000 consecutive emergency department encounters at their institution between April of 2009 and April of 2013 and found 1181 patients transferred for evaluation by plastic surgery. Using a retrospective ch... περισσότερα »

Breast Cancer–Related Lymphedema: Quality of Life after Lymph Node Transfer

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: Breast cancer–related lymphedema affects multiple aspects of patients’ daily lives. The main aim of this study was to assess the impact of vascularized lymph node transfer on the quality of life in patients with lymphedema. Methods: Between 2007 and 2012, 25 female patients with breast cancer–related lymphedema underwent vascularized lymph node transfer. In 22 cases, the patients underwent a simultaneous deep inferior epigastric artery perforator flap breast reconstruction based on the superficial circumflex iliac artery. The influence on quality of life wa...περισσότερα »

Effect of Cooling on Free Flap Ischemia

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1TFVu5i via IFTTT

Clinical Significance of Internal Mammary Lymph Node Biopsy during Microsurgical Breast Reconstruction: Review of 264 Cases

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: Despite the knowledge of alternate lymphatic draining patterns of the breast, routine evaluation of the internal mammary lymph node basin is still not considered standard of care. The advent of microsurgical breast reconstruction using the internal mammary vessels as recipients, however, has allowed sampling of internal mammary lymph nodes with technical ease, thus revisiting their role in breast cancer management. In the present study, the authors reviewed their experience with this practice. Methods: A retrospective analysis of patients who underwent inte...περισσότερα »

Plastic Surgery Complete: The Clinical Masters of PRS Breast eBooks

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/27TtcM3 via IFTTT

Breast Reconstruction with SIEA Flaps: A Single-Institution Experience with 145 Free Flaps

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: Refinements in microsurgical breast reconstruction have refined superficial inferior epigastric artery (SIEA) and superficial circumflex iliac artery (SCIA) flaps, yet technical difficulties and varied success rates limit widespread acceptance. The authors present the outcomes of their experience with 145 consecutive SIEA/SCIA flaps and suggest technical tips to improve success with this important flap. Methods: An institutional review board–approved retrospective chart review of all SIEA/SCIA free flaps performed by the senior authors between January 1, 20... περισσότερα »

Reply: Comparison of Outcomes for Normal Saline and an Antiseptic Solution for Negative-Pressure Wound Therapy with Instillation

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1TFVuSO via IFTTT

Revisions in Implant-Based Breast Reconstruction: How Does Direct-to-Implant Measure Up?

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: Immediate direct-to-implant breast reconstruction is increasingly performed for breast cancer treatment or prevention. The advantage over traditional tissue expander/implant reconstruction includes the potential for fewer surgical procedures. Methods: Retrospective, single-institution, three-surgeon review identified patients undergoing implant-based reconstruction from 2006 to 2011. Results: Six hundred eighty-two reconstructions were performed in 432 women with an average follow-up of 5 years. Four hundred sixty-five were direct-to-implant reconstructions... περισσότερα »

Evolving Concepts of Keystone Perforator Island Flaps (KPIF): Principles of Perforator Anatomy, Design Modifications, and Extended Clinical Applications

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: Keystone flaps have demonstrated growing clinical applications in reconstructive surgery in the past decade. This article highlights flap modifications and their versatility for clinical applications and management of complex defects. Methods: A retrospective chart review was conducted of consecutive patients undergoing keystone flap reconstruction at the authors’ institution from January of 2012 to December of 2014. Patient demographics, indications, and operative and postoperative details were abstracted. Results: Forty-two keystone flaps were performed i... περισσότερα »

Coagulation Changes following Combined Ablative and Reconstructive Breast Surgery

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: This study assessed hemostatic function in cancer patients at high risk for venous thromboembolism. Methods: Thirty-eight female patients (age, 53 ± 9 years) undergoing immediate postmastectomy reconstruction were prospectively studied with informed consent. Blood was sampled preoperatively, on postoperative day 1, and at 1 week follow-up. Rotational thromboelastography clotting time, α-angle (clot kinetics), clot formation time, and maximum clot firmness were studied with three different activating agents: intrinsically activated test using ellagic acid, e...περισσότερα »

Analysis of References on the Plastic Surgery In-Service Training Exam

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: The Plastic Surgery In-Service Training Exam is a knowledge assessment tool widely used during plastic surgery training in the United States. This study analyzed literature supporting correct answer choices to determine highest yield sources, journal publication lag, and journal impact factors. Methods: Digital syllabi of 10 consecutive Plastic Surgery In-Service Training Exam administrations (2006 to 2015) were reviewed. The most-referenced articles, journals, and textbooks were determined. Mean journal impact factor and publication lag were calculated and...περισσότερα »

Implant-Based Breast Reconstruction Using a Polyester Mesh (Surgimesh-PET): A Retrospective Single-Center Study

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: Although the introduction of acellular dermal matrices is considered one of the most important advancements in alloplastic breast reconstruction, costs and local policy limit their use in Italy. The purpose of this study was to assess short-term outcomes following Surgimesh-PET–based breast reconstruction. Methods: A single-center, retrospective, case-control study was performed from January 1, 2012, to December 31, 2013, by enrolling 206 breast reconstructions performed in 196 patients after oncologic (n = 200) or prophylactic (n = 6) mastectomy. Group A i...περισσότερα »

Reply: Face-Lift Satisfaction Using the FACE-Q

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/27Tt2nX via IFTTT

Skin-Reduction Breast Reconstructions with Prepectoral Implant

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Summary: Skin-reduction mastectomy with prepectoral implant reconstruction is a novel technique for immediate breast reconstruction, with subcutaneous implant placement in patients eligible for skin-reducing mastectomy. Implants were placed above the pectoralis muscles in a compound pocket made by a dermal flap and acellular dermal matrix. The procedure was performed on 33 breasts in 27 selected patients. In three cases, there was skin ischemia; in one case, it healed spontaneously; and in two patients, a surgical necrosectomy and primary closure were needed. No implant... περισσότερα »

Reply: Progressive Tightening of the Levator Veli Palatini Muscle Improves Velopharyngeal Dysfunction in Early Outcomes of Primary Palatoplasty

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1TFVGBp via IFTTT

A Comparison of the Full and Short-Scar Face-Lift Incision Techniques in Multiple Sets of Identical Twins

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]Background: Choosing the ideal face-lift technique for a patient presents an added challenge for the plastic surgeon. With the multitude of well-established variations of this procedure, it would be beneficial to define which facioplasty technique produces the optimal result. By comparing the postoperative results from two of the most popularized face-lift incision techniques in monozygotic twins, it is hypothesized that the “best” technique may be determined. Methods: Four sets of identical twins and one set of identical triplets underwent face-lift surgery performed ... περισσότερα »

Discussion: A Comparison of the Full and Short-Scar Face-Lift Incision Techniques in Multiple Sets of Identical Twins

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G. SfakianakisΠριν από 51 δευτερόλεπτα
[image: image]No abstract available from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/27TsFK1 via IFTTT

Sphenoidal pneumosinus dilatans due to anterior skull base meningiomas - CT and MRI aspects: Report of two new cases and literature review.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 52 δευτερόλεπτα
*Sphenoidal pneumosinus dilatans due to anterior skull base meningiomas - CT and MRI aspects: Report of two new cases and literature review.* Neuroradiol J. 2016 May 24; Authors: Scuotto A, Saracino D, Rotondo M, Izzo A, Urraro F, Cappabianca S, Sampaolo S Abstract We report on two patients disclosing a pneumosinus dilatans (PSD) and an anterior skull base meningioma. Our findings, together with those from the pertinent literature, support the thought that this infrequent anomaly of paranasal sinuses is a useful clue to suspect a concomitant meningioma. Moreover, hypotheses conce... περισσότερα »

[Verrucous carcinoma in the left lateral skull base: a case report].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 52 δευτερόλεπτα
*[Verrucous carcinoma in the left lateral skull base: a case report].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 May 7;51(5):387-9 Authors: Cheng P, Tang SX, Qing J PMID: 27220302 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1OOYTuj via IFTTT

[The clinical experience of transnasal endoscopic approach for skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 52 δευτερόλεπτα
*[The clinical experience of transnasal endoscopic approach for skull base osteoradionecrosis after radiotherapy for nasopharyngeal carcinoma].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 May 7;51(5):367-71 Authors: Lan GP, Huang B, Si YF, Qin YD, Deng ZX, Yang Y, Qin Y, Zhang BJ Abstract OBJECTIVE: To investigate the method of surgical treatment via trans-nasal endoscopic approach in osteoradionecrosis of skull base after radiotherapy for nasopharyngeal carcinoma. METHODS: Fifteen patients with osteoradionecrosis of skull base after radiotherapy for nasopharyngeal carcino... περισσότερα »

[Analyses of chronic otitis media with intact tympanic membrane concurrent with intracranial complication].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 52 δευτερόλεπτα
*[Analyses of chronic otitis media with intact tympanic membrane concurrent with intracranial complication].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 May 7;51(5):343-7 Authors: Wang XQ, Wu PN, Huang HM, Fu M, Ge RM Abstract OBJECTIVE: To investigate the clinical and imaging characteristics of chronic otitis media with intact tympanic membrane. METHOD: Ten patients were retrospective studied in the department of otorhinolaryngology of Guangdong general hospital from December 2006 to January 2015. The clinical characteristics of their manifestations, audiology and imagin... περισσότερα »

[Attaching importance to standardization of diagnosis and treatment in otitis media].

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 52 δευτερόλεπτα
*[Attaching importance to standardization of diagnosis and treatment in otitis media].* Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 May 7;51(5):321-3 Authors: Sun JJ, Chi FL PMID: 27220288 [PubMed - in process] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1OZxECK via IFTTT

Role of ATG10 expression quantitative trait loci in non-small cell lung cancer survival

Abstract To evaluate whether genetic variants in autophagy-related genes affect the overall survival (OS) of non-small cell lung cancer (NSCLC) patients. We analyzed 14 single nucleotide polymorphisms (SNPs) in core autophagy-related genes for OS in 1001 NSCLC patients. Three promising SNPs in ATG10 were subsequently annotated by the expression quantitative trait loci (eQTL) and methylation […]

Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

Abstract Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from […]

Functional and structural cortical characteristics after restricted focal motor cortical infarction evaluated at chronic stage – indications from a preliminary study

Publication date: Available online 26 May 2016 Source:Clinical Neurophysiology Author(s): Petro Julkunen, Sara Määttä, Laura Säisänen, Elisa Kallioniemi, Mervi Könönen, Pekka Jäkälä, Ritva Vanninen, Selja Vaalto ObjectiveTo assess the inter-hemispheric differences in neuronal function and structure of the motor cortex in a small group of chronic stroke patients having suffered a restricted ischemic lesion affecting […]

Age-dependent characteristics of feedback evaluation related to monetary gains and losses

Publication date: Available online 25 May 2016 Source:International Journal of Psychophysiology Author(s): Zsófia Kardos, Brigitta Tóth, Roland Boha, Bálint File, Márk Molnár Monitoring the consequences of actions is of crucial importance in order to optimize behavior to the challenges of the environment. Recently the age-related aspects of this fundamentally important cognitive processing have been brought […]

Evaluation of type II thyroplasty on phonatory physiology in an excised canine larynx model.

Evaluation of type II thyroplasty on phonatory physiology in an excised canine larynx model. Laryngoscope. 2016 May 25; Authors: Devine EE, Hoffman MR, McCulloch TM, Jiang JJ Abstract OBJECTIVES/HYPOTHESIS: Type II thyroplasty is an alternative treatment for spasmodic dysphonia, addressing hyperadduction by incising and lateralizing the thyroid cartilage. We quantified the effect of lateralization width […]

Preschoolers’ Preference for Syntactic Complexity Varies by Socioeconomic Status.

Preschoolers’ Preference for Syntactic Complexity Varies by Socioeconomic Status. Child Dev. 2016 May 25; Authors: Corriveau KH, Kurkul K, Arunachalam S Abstract Two experiments investigated whether 4- and 5-year-old children choose to learn from informants who use more complex syntax (passive voice) over informants using more simple syntax (active voice). In Experiment 1 (N = […]

Neopharyngeal diverticulum.

Related Articles Neopharyngeal diverticulum. Ear Nose Throat J. 2014 Aug;93(8):297 Authors: Howell RJ, Postma GN PMID: 25181656 [PubMed – indexed for MEDLINE] from Speech via xlomafota13 on Inoreader http://ift.tt/1NPeP4E from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Z2efBe via IFTTT

Long-term follow-up of amitriptyline treatment for idiopathic cough.

Long-term follow-up of amitriptyline treatment for idiopathic cough. Laryngoscope. 2016 May 25; Authors: Ryan MA, Cohen SM Abstract OBJECTIVES/HYPOTHESIS: To evaluate short- and long-term treatment outcomes of amitriptyline for idiopathic cough. STUDY DESIGN: Retrospective chart review and anonymous survey of a patient cohort. METHODS: We evaluated a cohort of adults treated for cough at the […]

A Qualitative Evaluation of the Acceptability of an Interactive Voice Response System to Enhance Adherence to Isoniazid Preventive Therapy Among People Living with HIV in Ethiopia.

A Qualitative Evaluation of the Acceptability of an Interactive Voice Response System to Enhance Adherence to Isoniazid Preventive Therapy Among People Living with HIV in Ethiopia. AIDS Behav. 2016 May 24; Authors: Daftary A, Hirsch-Moverman Y, Kassie GM, Melaku Z, Gadisa T, Saito S, Howard AA Abstract Interactive voice response (IVR) is increasingly used to […]

Giving voice to quality and safety matters at board level: A qualitative study of the experiences of executive nurses working in England and Wales.

Giving voice to quality and safety matters at board level: A qualitative study of the experiences of executive nurses working in England and Wales. Int J Nurs Stud. 2016 Jul;59:169-76 Authors: Jones A, Lankshear A, Kelly D Abstract BACKGROUND: Recent reports into egregious failing in the quality and safety of healthcare in the UK have […]

Functional and structural cortical characteristics after restricted focal motor cortical infarction evaluated at chronic stage – indications from a preliminary study

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: Available online 26 May 2016 *Source:*Clinical Neurophysiology Author(s): Petro Julkunen, Sara Määttä, Laura Säisänen, Elisa Kallioniemi, Mervi Könönen, Pekka Jäkälä, Ritva Vanninen, Selja Vaalto ObjectiveTo assess the inter-hemispheric differences in neuronal function and structure of the motor cortex in a small group of chronic stroke patients having suffered a restricted ischemic lesion affecting hand motor representation. GABAergic intracortical inhibition, known to be affected by stroke lesion, was also investigated.MethodsEight patients ... περισσότερα »

Age-dependent characteristics of feedback evaluation related to monetary gains and losses

Alexandros G. SfakianakisστοPhysiology by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: alertIcon.gif] Publication date: Available online 25 May 2016 *Source:*International Journal of Psychophysiology Author(s): Zsófia Kardos, Brigitta Tóth, Roland Boha, Bálint File, Márk Molnár Monitoring the consequences of actions is of crucial importance in order to optimize behavior to the challenges of the environment. Recently the age-related aspects of this fundamentally important cognitive processing have been brought into the focus of investigation since behavioral monitoring and related control mechanisms are widely known to be affected by aging. Processing of feedba... περισσότερα »

Brain Sciences, Vol. 6, Pages 16: Prior Binge Ethanol Exposure Potentiates the Microglial Response in a Model of Alcohol-Induced Neurodegeneration

Excessive alcohol consumption results in neurodegeneration which some hypothesize is caused by neuroinflammation. One characteristic of neuroinflammation is microglial activation, but it is now well accepted that microglial activation may be pro- or anti-inflammatory. Recent work indicates that the Majchrowicz model of alcohol-induced neurodegeneration results in anti-inflammatory microglia, while intermittent exposure models with lower doses […]

Historic air pollution exposure and long-term mortality risks in England and Wales : prospective longitudinal cohort study

Long-term air pollution exposure contributes to mortality but there are few studies examining effects of very long-term (&gt;25 years) exposures.; This study investigated modelled air pollution concentrations at residence for 1971, 1981, 1991 (black smoke (BS) and SO2) and 2001 (PM10) in relation to mortality up to 2009 in 367 658 members of the longitudinal survey, a […]

Cost-effectiveness of community-wide treatment for helminthiasis – Authors’ reply

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/25jlto9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 &amp; 00306932607174

National and sub-national drinking water fluoride concentrations and prevalence of fluorosis and of decayed, missed, and filled teeth in Iran from 1990 to 2015 : a systematic review

Fluoride intake, fluorosis, and dental caries could affect quality of life and disease burden worldwide. As a part of the National and Sub-national Burden of Disease Study (NASBOD) in Iran, we conducted a systematic review to evaluate province-year-specific mean drinking water fluoride concentrations and prevalence of fluorosis and of decayed, missed, and filled teeth (DMFT) […]

Modelling the health impact and cost-effectiveness of lymphatic filariasis eradication under varying levels of mass drug administration scale-up and geographic coverage

from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/25jlYyw via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 &amp; 00306932607174

Household and personal factors are sources of heterogenity in intestinal parasite clearance among Mexican children 6-15 months of age supplemented with vitamin A and zinc

A randomised, double-blind, placebo-controlled trial was carried out among Mexico children aged 6-15 months to determine how household characteristics modify vitamin A and zinc supplementation efficacy on Ascaris lumbricoides, Giardia intestinalis and Entamoeba histolytica/E. dispar infection durations. Children assigned to receive vitamin A every 2 months, a daily zinc supplement, a combined vitamin A-zinc supplement […]

Public health impacts of city policies to reduce climate change : findings from the URGENCHE EU-China project

Climate change is a global threat to health and wellbeing. Here we provide findings of an international research project investigating the health and wellbeing impacts of policies to reduce greenhouse gas emissions in urban environments.; Five European and two Chinese city authorities and partner academic organisations formed the project consortium. The methodology involved modelling the […]

Health impacts of active transportation in Europe

Policies that stimulate active transportation (walking and bicycling) have been related to heath benefits. This study aims to assess the potential health risks and benefits of promoting active transportation for commuting populations (age groups 16-64) in six European cities. We conducted a health impact assessment using two scenarios: increased cycling and increased walking. The primary […]

The effects of an oil and wheat flour fortification program on pre-school children and women of reproductive age living in Côte d’Ivoire, a malaria-endemic area

Anemia and micronutrient deficiencies are widespread in sub-Saharan Africa, but the impact of food fortification is still debated. The objective of this study was to estimate the iron and vitamin A status of preschool children (PSC) and women of reproductive age (WRA) in households consuming fortified oil and wheat flour. The survey was cross-sectional in […]

Malaria transmission dynamics surrounding the first nationwide long-lasting insecticidal net distribution in Papua New Guinea

The major malaria vectors of Papua New Guinea exhibit heterogeneities in distribution, biting behaviour and malaria infection levels. Long-lasting, insecticide-treated nets (LLINs), distributed as part of the National Malaria Control Programme, are the primary intervention targeting malaria transmission. This study evaluated the impact of LLINs on anopheline density, species composition, feeding behaviour, and malaria transmission.; […]

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.* Oncotarget. 2016 May 20; Authors: Canela MD, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, Jimeno ML, Benkheil M, Ribatti D, Velázquez S, Camarasa MJ, Díaz JF, Steinmetz MO, Priego EM, Pérez-Pérez MJ, Liekens S Abstract We investigated the microtubule-destabilizing, vascular-targeting, anti-tumor and anti-metastatic activities of a new series of chalcones, whose prototype compound is (E)-3-(3''-amino-4''-methoxyphenyl)-1-(5'-methoxy-3',4'-methylendioxyphenyl)-2-methylprop-2-en-1-one (TUB091)... περισσότερα »

Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol.* Pigment Cell Melanoma Res. 2016 May 25; Authors: Kondo M, Kawabata K, Sato K, Yamaguchi S, Hachiya A, Takahashi Y, Inoue S Abstract Rhododendrol is a phenolic compound that shows a tyrosinase-dependent toxicity for melanocytes and occasionally induces a vitiligo-like skin depigmentation. The post-tyrosinase mechanisms determining melanocyte death or survival, however, are far from clear. Here we find that RD treatment leads to a reduction in the levels of cellular glutathione but also...περισσότερα »

Frizzled with age: An opportunity for "gerontological" medicine.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Frizzled with age: An opportunity for "gerontological" medicine.* Pigment Cell Melanoma Res. 2016 May 25; Authors: Teh JL Abstract Cancer shows a strong association with aging and prognosis in aged individuals is usually poor. A widely accepted paradigm attributes this phenomenon to the accumulation of oncogenic mutations over time. While independently associated with age, mutually exclusive mutations BRAF and NRAS encompass nearly 75% of all cases in melanoma. Furthermore, these mutations alone are usually insufficient for tumor initiation. Nevi harboring activating mutations i...περισσότερα »

BRAF inhibitor and stereotactic radiosurgery is associated with an increased risk of radiation necrosis.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*BRAF inhibitor and stereotactic radiosurgery is associated with an increased risk of radiation necrosis.* Melanoma Res. 2016 May 24; Authors: Patel KR, Chowdhary M, Switchenko JM, Kudchadkar R, Lawson DH, Cassidy RJ, Prabhu RS, Khan MK Abstract We retrospectively compared the outcomes and toxicities of melanoma brain metastases (MBM) patients treated with BRAF inhibitors (BRAFi) and stereotactic radiosurgery (SRS) with SRS alone. We identified 87 patients with 157 MBM treated with SRS alone from 2005 to 2013. Of these, 15 (17.2%) patients with 32 MBM (21.4%) received BRAFi thera... περισσότερα »

Prognostic significance of nestin in primary malignant melanoma of the oral cavity.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Prognostic significance of nestin in primary malignant melanoma of the oral cavity.* Melanoma Res. 2016 May 24; Authors: Kuk SK, Won CH, Lee WJ, Shin WJ, Yoon HJ, Hong SD, Hong SP, Lee JI Abstract Several studies have examined the correlation between nestin expression and the degree of tumor invasion in cutaneous melanoma. However, no information has been reported on nestin in primary mucosal melanoma of the head and neck. The present study examined the expression and prognostic significance of nestin in patients with primary mucosal melanoma of the oral cavity. Nestin expressio... περισσότερα »

Tumor-tropic endothelial colony forming cells (ECFCs) loaded with near-infrared sensitive Au nanoparticles: A "cellular stove" approach to the photoablation of melanoma.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Tumor-tropic endothelial colony forming cells (ECFCs) loaded with near-infrared sensitive Au nanoparticles: A "cellular stove" approach to the photoablation of melanoma.* Oncotarget. 2016 May 20; Authors: Margheri G, Zoppi A, Olmi R, Trigari S, Traversi R, Severi M, Bani D, Bianchini F, Torre E, Margheri F, Chillà A, Biagioni A, Calorini L, Laurenzana A, Fibbi G, Del Rosso M Abstract In the photothermal treatments (PTs) of tumor, the localization of a high number of near-infrared (NIR) absorbing gold nanoparticles in the tumor mass is still a challenging issue. Here, we propose ... περισσότερα »

Nivolumab for Metastatic Melanoma.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Nivolumab for Metastatic Melanoma.* Skin Therapy Lett. 2016 Mar;21(2):6-9 Authors: Gupta AK, Daigle D Abstract Melanoma is an aggressive skin cancer with a generally poor prognosis at Stage III-IV disease. Traditionally, metastatic melanoma was treated by surgical resection, when possible, and with systemic chemotherapy. New developments in molecular biology have led to the identification of immune checkpoints which are exploited by malignant cells, allowing them to go undetected by the immune system. Nivolumab (Opdivo®) is a human monoclonal antibody which prevents immune inhib... περισσότερα »

Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Activated dendritic cells delivered in tissue compatible biomatrices induce in-situ anti-tumor CTL responses leading to tumor regression.* Oncotarget. 2016 May 21; Authors: Verma V, Kim Y, Lee MC, Lee JT, Cho S, Park IK, Min JJ, Lee JJ, Lee SE, Rhee JH Abstract Dendritic cell (DC) based anti-cancer immunotherapy is well tolerated in patients with advanced cancers. However, the clinical responses seen after adoptive DC therapy have been suboptimal. Several factors including scarce DC numbers in tumors and immunosuppressive tumor microenvironments contribute to the inefficacy of D...περισσότερα »

Time to reconsider Spitzoid neoplasms?

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Time to reconsider Spitzoid neoplasms?* Dermatol Pract Concept. 2016 Apr;6(2):43-8 Authors: Urso C Abstract BACKGROUND: Spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions. An extraordinarily large number of studies have been made in attempts to solve this problem; regrettably, the histological criteria proposed and the various special sophisticated techniques employed have proven to be ineffective in making this distinction with confidence. OBJECTIVES: ... περισσότερα »

Spitz/Reed nevi: a review of clinical-dermatoscopic and histological correlation.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Spitz/Reed nevi: a review of clinical-dermatoscopic and histological correlation.* Dermatol Pract Concept. 2016 Apr;6(2):37-41 Authors: Pedrosa AF, Lopes JM, Azevedo F, Mota A Abstract BACKGROUND: Spitz/Reed nevi are melanocytic lesions that may mimic melanoma at clinical, dermatoscopic and histopathological levels. Management strategies of these lesions remain controversial. OBJECTIVES: We aim a correlation among clinical-dermatoscopic and histological features of a series of Spitz/Reed nevi diagnosed during 7 years at the Department of Dermatology. METHODS: Clinical, dermatosco...περισσότερα »

Validity of self-reported family history of cancer: A systematic literature review on selected cancers.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Validity of self-reported family history of cancer: A systematic literature review on selected cancers.* Int J Cancer. 2016 May 24; Authors: Fiederling J, Shams AZ, Haug U Abstract Evidence regarding validity of self-reported family history of cancer (FHC) has been reviewed only for breast, colorectal, prostate, ovarian, endometrial and uterine cancer. We aimed to systematically review studies assessing validity of self-reported family history for the remaining cancer sites. We searched the Medline database for relevant studies published by January 2016. We extracted information... περισσότερα »

[Expression of protein 4.1 family in melanoma cell lines and its effect on cell proliferation].

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*[Expression of protein 4.1 family in melanoma cell lines and its effect on cell proliferation].* Nan Fang Yi Ke Da Xue Xue Bao. 2016 May 20;36(5):649-54 Authors: Men YL, Kang QZ, Ding C, Liu SM, Jiang H, Wang XD, Ji ZY, Liu X, Wang T Abstract OBJECTIVE: To detect the expression of protein 4.1 family members in mouse melanoma cell lines and evaluate their effect on cell proliferation. METHODS: PCR and Western blot were used to detected to the expression of protein 4.1 family members (4.1R, 4.1B, 4.1G, and 4.1N) at the mRNA and protein levels in B16 and B16-F10 cell lines. The expr...περισσότερα »

[Tumors of the lacrimal drainage system].

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*[Tumors of the lacrimal drainage system].* HNO. 2016 May 24; Authors: von Goscinski C, Koch KR, Cursiefen C, Heindl LM Abstract BACKGROUND: The prevalence of tumors affecting the lacrimal drainage system is low, thus generating a risk of late diagnosis and treatment in clinical routine. However, these tumors can be potentially life-threatening, which emphasizes the relevance of early diagnosis and treatment. OBJECTIVE: This review focuses on the symptoms, incidence, management, and prognosis of the different tumor entities affecting the lacrimal drainage system. METHODS: The stud...περισσότερα »

Evaluation of Anticancer Activity of Curcumin Analogues Bearing a Heterocyclic Nucleus.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Evaluation of Anticancer Activity of Curcumin Analogues Bearing a Heterocyclic Nucleus.* Asian Pac J Cancer Prev. 2016;17(4):1739-44 Authors: Ahsan MJ, Ahsan MJ Abstract We report herein an in vitro anticancer evaluation of a series of seven curcumin analogues (3a-g). The National Cancer Institute (NCI US) Protocol was followed and all the compounds were evaluated for their anticancer activity on nine different panels (leukemia, non small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, prostate cancer and breast cancer) represented by 60 NCI h...περισσότερα »

The membrane tethered Matrix Metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*The membrane tethered Matrix Metalloproteinase MT1-MMP at the forefront of melanoma cell invasion and metastasis.* Pharmacol Res. 2016 May 21; Authors: Thakur V, Bedogni B Abstract The Extracellular Matrix (ECM) plays an important role in normal physiological development and functioning of cells, tissues and organs [1]. Under normal physiological conditions degradation of the ECM is a finely regulated process, and altered homeostasis of ECM degradation (excessive or insufficient) is associated with many diseases [2-5] such as cancer, fibrosis, arthritis, nephritis, encephalomyel...περισσότερα »

Adenosine 2B receptor expression on cancer cells promotes metastasis.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Adenosine 2B receptor expression on cancer cells promotes metastasis.* Cancer Res. 2016 May 24; Authors: Mittal D, Sinha D, Barkauskas D, Young A, Kalimutho M, Stannard K, Caramia F, Haibe-Kains B, Stagg J, Khanna KK, Loi S, Smyth MJ Abstract Adenosine plays an important role in inflammation and tumor development, progression and responses to therapy. We show that an adenosine 2B receptor inhibitor (A2BRi) decreases both experimental and spontaneous metastasis and combines with chemotherapy or immune checkpoint inhibitors in mouse models of melanoma and triple-negative breast can... περισσότερα »

Innate Immune Receptors.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Innate Immune Receptors.* Methods Mol Biol. 2016;1417:1-43 Authors: Muñoz-Wolf N, Lavelle EC Abstract For many years innate immunity was regarded as a relatively nonspecific set of mechanisms serving as a first line of defence to contain infections while the more refined adaptive immune response was developing. The discovery of pattern recognition receptors (PRRs) revolutionised the prevailing view of innate immunity, revealing its intimate connection with adaptive immunity and generation of effector and memory T- and B-cell responses. Among the PRRs, families of Toll-like recep...περισσότερα »

LYMPHA Technique to Prevent Secondary Lower Limb Lymphedema.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*LYMPHA Technique to Prevent Secondary Lower Limb Lymphedema.* Ann Surg Oncol. 2016 May 24; Authors: Boccardo F, Valenzano M, Costantini S, Casabona F, Morotti M, Sala P, De Cian F, Molinari L, Spinaci S, Dessalvi S, Campisi CC, Villa G, Campisi C Abstract BACKGROUND: Inguinofemoral lymphadenectomy carries a high risk of lower limb lymphedema. This report describes the feasibility of performing multiple lymphatic-venous anastomoses (MLVA) after inguinofemoral lymph node completion (LYMPHA technique) and the possible benefit of LYMPHA for preventing lymphedema. METHODS: Between Fe... περισσότερα »

Pigment Production Analysis in Human Melanoma Cells.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Pigment Production Analysis in Human Melanoma Cells.* Methods Mol Biol. 2016 May 25; Authors: Hopkin AS, Paterson EK, Ruiz R, Ganesan AK Abstract The human epidermal melanocyte is a highly specialized pigmented cell that serves to protect the epidermis from ultraviolet (UV) damage through the production of melanin, or melanogenesis. Misregulation in melanogenesis leading to either hyper- or hypo-pigmentation is found in human diseases such as malasma and vitiligo. Current therapies for these diseases are largely unsuccessful and the need for new therapies is necessary. In order ...περισσότερα »

Whole-genome DNA methylation and hydroxymethylation profiling for HBV-related hepatocellular carcinoma.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
*Whole-genome DNA methylation and hydroxymethylation profiling for HBV-related hepatocellular carcinoma.* Int J Oncol. 2016 May 24; Authors: Ye C, Tao R, Cao Q, Zhu D, Wang Y, Wang J, Lu J, Chen E, Li L Abstract Hepatocellular carcinoma (HCC) is a common solid tumor worldwide with a poor prognosis. Accumulating evidence has implicated important regulatory roles of epigenetic modifications in the occurrence and progression of HCC. In the present study, we analyzed 5-methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) levels in the tumor tissues and paired adjacent peritumor ...περισσότερα »

BRAF inhibitor and stereotactic radiosurgery is associated with an increased risk of radiation necrosis.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
We retrospectively compared the outcomes and toxicities of melanoma brain metastases (MBM) patients treated with BRAF inhibitors (BRAFi) and stereotactic radiosurgery (SRS) with SRS alone. We identified 87 patients with 157 MBM treated with SRS alone from 2005 to 2013. Of these, 15 (17.2%) patients with 32 MBM (21.4%) received BRAFi therapy: three (20.0%) before SRS, two (13.3%) concurrent, and 10 (66.7%) after SRS. Overall survival (OS) was compared between cohorts using the product limit method. Intracranial outcomes were compared using cumulative incidence with competing risk for... περισσότερα »

Prognostic significance of nestin in primary malignant melanoma of the oral cavity.

Alexandros G. SfakianakisστοMelanoma by Alexandros G. SfakianakisΠριν από 1 ώρα
Several studies have examined the correlation between nestin expression and the degree of tumor invasion in cutaneous melanoma. However, no information has been reported on nestin in primary mucosal melanoma of the head and neck. The present study examined the expression and prognostic significance of nestin in patients with primary mucosal melanoma of the oral cavity. Nestin expression was examined immunohistochemically in 39 patients (six oral melanoma in-situ cases and 33 invasive oral melanoma cases) and analyzed for association with disease progression. Age, sex, anatomic site, ...περισσότερα »

Personal music systems and hearing.

Personal music systems and hearing. J Laryngol Otol. 2016 May 25;:1-13 Authors: Kumar UA, Deepashree SR Abstract OBJECTIVES: To measure the output sound pressure levels of personal music systems and evaluate their effect on hearing. METHODS: Output sound pressure levels at preferred volume settings and listening environment were measured using a manikin. Effects of personal […]

A Review of Whole Exome Sequencing Efforts Toward Hereditary Breast Cancer Susceptibility Gene Discovery

ABSTRACT Inherited genetic risk factors contribute towards breast cancer (BC) onset. BC risk variants can be divided into three categories of penetrance (high, moderate, and low) that reflect the probability of developing the disease. Traditional BC susceptibility gene discovery approaches that searched for high and moderate risk variants in familial BC cases have had limited […]

Influence of GRIK4 genetic variants on the electroconvulsive therapy response.

Influence of GRIK4 genetic variants on the electroconvulsive therapy response. Neurosci Lett. 2016 May 17; Authors: Minelli A, Congiu C, Ventriglia M, Bortolomasi M, Bonvicini C, Abate M, Sartori R, Gainelli G, Gennarelli M Abstract Several lines of evidence have shown the involvement of the glutamatergic system in the function of electroconvulsive therapy (ECT). In […]

Bariatric surgery in case of morbid obesity in adolescence: efficient but….

[Bariatric surgery in case of morbid obesity in adolescence: efficient but…]. Rev Med Suisse. 2016 Mar 2;12(508):477 Authors: Blondel N PMID: 27089610 [PubMed – indexed for MEDLINE] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TLlZYl via IFTTT

WILL THE BOOK OF LIFE BECOME AGAIN ONE DAY WHAT IT HAD BEEN?.

[WILL THE BOOK OF LIFE BECOME AGAIN ONE DAY WHAT IT HAD BEEN?]. Rev Med Suisse. 2016 Mar 2;12(508):476-7 Authors: Nau JY PMID: 27089609 [PubMed – indexed for MEDLINE] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1sAy4oM via IFTTT

Can be reduced the polypharmacy at the multi morbidity patients?.

[Can be reduced the polypharmacy at the multi morbidity patients?]. Rev Med Suisse. 2016 Mar 2;12(508):427-8 Authors: Rodondi N PMID: 27089597 [PubMed – indexed for MEDLINE] from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TLm8uS via IFTTT

Topical Therapies for Psoriasis: Improving Management Strategies and Patient Adherence.

Related Articles Topical Therapies for Psoriasis: Improving Management Strategies and Patient Adherence. Semin Cutan Med Surg. 2016 Mar;35(2 Suppl 2):S36-44; quiz S45 Authors: Stein Gold LF Abstract Psoriasis is a chronic disease that has a substantial effect on quality of life of patients and often needs long-term treatment. Topical treatments for psoriasis include corticosteroids, vitamin […]

Which mesh or graft? Prosthetic devices for abdominal wall reconstruction.

Related Articles Which mesh or graft? Prosthetic devices for abdominal wall reconstruction. Br J Hosp Med (Lond). 2016 Mar;77(3):157-8, 159-61 Authors: Abid S, El-Hayek K Abstract This article reviews the ever-increasing number of prosthetic devices–both synthetic mesh and biologic grafts–now in use for abdominal wall reconstruction. It also introduces a novel hybrid synthetic/biologic graft (Zenapro) […]

Biological hazards and healthcare-associated infections in Italian healthcare facilities: some considerations on inspections and accountability.

Related Articles Biological hazards and healthcare-associated infections in Italian healthcare facilities: some considerations on inspections and accountability. Ann Ig. 2015 Nov-Dec;27(6):799-807 Authors: Messineo A, Marsella LT Abstract Healthcare-associated infections are a major clinical and public health problem that involve, in a variety of ways, healthcare professionals, hospital administrators and, above all, patients. In Italy, the […]

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.

Related Articles American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline. CA Cancer J Clin. 2016 Jan-Feb;66(1):43-73 Authors: Runowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA Abstract Answer […]

Lateral Skull Base Attenuation in Superior Semicircular Canal Dehiscence and Spontaneous Cerebrospinal Fluid Otorrhea.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Lateral Skull Base Attenuation in Superior Semicircular Canal Dehiscence and Spontaneous Cerebrospinal Fluid Otorrhea.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Rizk HG, Hatch JL, Stevens SM, Lambert PR, Meyer TA Abstract OBJECTIVES: (1) To quantitatively assess the lateral skull base thickness in patients with superior semicircular canal dehiscense (SSCD) using a standardized and validated radiographic measure and to compare it with that of a population with spontaneous cerebrospinal fluid otorrhea (CSFO). (2) To analyze demographic and clinical factors associated with ...περισσότερα »

Independent and joint exposure to passive smoking and cooking oil fumes on oral cancer in Chinese women: a hospital-based case-control study.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Independent and joint exposure to passive smoking and cooking oil fumes on oral cancer in Chinese women: a hospital-based case-control study.* Acta Otolaryngol. 2016 May 25;:1-5 Authors: He B, Chen F, Yan L, Huang J, Liu F, Qiu Y, Lin L, Zhang Z, Cai L Abstract CONCLUSIONS: Passive smoking and COF exposure are independent risk factors for oral cancer in Chinese women, with the multiplicative interactions from combined exposures. Avoiding exposure to environmental tobacco smoke and COF may contribute to the prevention of oral cancer in Chinese women. OBJECTIVE: To evaluate the inde... περισσότερα »

Video head impulse in comparison to caloric testing in unilateral vestibular schwannoma.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Video head impulse in comparison to caloric testing in unilateral vestibular schwannoma.* Acta Otolaryngol. 2016 May 25;:1-5 Authors: Tranter-Entwistle I, Dawes P, Darlington CL, Smith PF, Cutfield N Abstract CONCLUSIONS: Although there was a statistically significant relationship between the results of the vHIT and the caloric test, the limited strength of this relationship suggests that, for unilateral vestibular schwannoma (UVS), caloric testing and vHIT may provide complementary information on vestibular function. OBJECTIVE: There is limited information that can be used to de... περισσότερα »

Post-operative morbidity and 1-year outcomes in CO2-laser tonsillotomy versus dissection tonsillectomy.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Post-operative morbidity and 1-year outcomes in CO2-laser tonsillotomy versus dissection tonsillectomy.* Acta Otolaryngol. 2016 May 25;:1-8 Authors: Lourijsen ES, Wong Chung JE, Koopman JP, Blom HM Abstract OBJECTIVE: In this study a type of partial tonsil surgery, CO2-laser tonsillotomy, was compared to regular tonsillectomy. The effectiveness and post-operative recovery rate of both interventions in adult patients was assessed by using a questionnaire. STUDY DESIGN: Prospective follow-up non-randomized cohort study. METHOD: One hundred and seven adults were included; 46 tonsille... περισσότερα »

MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*MBL, P2X7, and SLC11A1 gene polymorphisms in patients with oropharyngeal tularemia.* Acta Otolaryngol. 2016 May 25;:1-5 Authors: Somuk BT, Koc S, Ates O, Göktas G, Soyalic H, Uysal IO, Gurbuzler L, Sapmaz E, Sezer S, Eyibilen A Abstract CONCLUSION: A significant association was found of oropharyngeal tularemia with SLC11A1 allele polymorphism (INT4 G/C) and MBL2 C + 4T (P/Q). These results indicate C allele and Q allele might be a risk factor for the development of oropharyngeal tularemia. AIM: This study aimed to investigate the relationship of SLC11A1, MBL, and P2X7 gene polym...περισσότερα »

A novel method for determining the relation between nasal polyposis and oxidative stress: the thiol/disulphide homeostasis.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*A novel method for determining the relation between nasal polyposis and oxidative stress: the thiol/disulphide homeostasis.* Acta Otolaryngol. 2016 May 25;:1-4 Authors: Şimşek E, Erel O, Bicer CK, Çarlıoğlu A Abstract CONCLUSION: It is thought that oxidative stress may be the major cause of the increase in the oxide thiol form in the study group. The relationship between oxidative stress status and dynamic thiol/disulphide in nasal polyposis now needs to be investigated. OBJECTIVES: The purpose of this study was to evaluate the relation between nasal polyposis and thiol/disulphid... περισσότερα »

AAOM Clinical Practice Statement: Oral Cancer Examination and Screening.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*AAOM Clinical Practice Statement: Subject: Oral Cancer Examination and Screening.* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 May 21; Authors: PMID: 27220604 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1OOTbbE via IFTTT

Are condylar morphologic changes associated with temporomandibular disorders in patients with orthognathia?

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Are condylar morphologic changes associated with temporomandibular disorders in patients with orthognathia?* Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Mar 15; Authors: Catherine Z, Courvoisier DS, Scolozzi P Abstract OBJECTIVE: To determine the association between morphologic condylar changes and temporomandibular disorders (TMDs) in patients with orthognathia. STUDY DESIGN: Data from 89 patients were analyzed. TMDs were classified according to the Research Diagnostic Criteria for TMDs. TMD severity was scored according to the Helkimo indices. Calculation of the condylar a...περισσότερα »

Does the Press Ganey Survey Correlate to Online Health Grades for a Major Academic Otolaryngology Department?

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Does the Press Ganey Survey Correlate to Online Health Grades for a Major Academic Otolaryngology Department?* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Ryan T, Specht J, Smith S, DelGaudio JM Abstract OBJECTIVES: Analyze the correlation between online-based review websites and the Press Ganey Patient Satisfaction Survey (PGPSS) in an academic otolaryngology department. STUDY DESIGN: Retrospective cross sectional. SETTING: Tertiary academic institution. METHODS: All available data were collected for Vitals.com and Healthgrades.com, along with PGPSS data for 16 otolaryngolo... περισσότερα »

Lateral Skull Base Attenuation in Superior Semicircular Canal Dehiscence and Spontaneous Cerebrospinal Fluid Otorrhea.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Lateral Skull Base Attenuation in Superior Semicircular Canal Dehiscence and Spontaneous Cerebrospinal Fluid Otorrhea.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Rizk HG, Hatch JL, Stevens SM, Lambert PR, Meyer TA Abstract OBJECTIVES: (1) To quantitatively assess the lateral skull base thickness in patients with superior semicircular canal dehiscense (SSCD) using a standardized and validated radiographic measure and to compare it with that of a population with spontaneous cerebrospinal fluid otorrhea (CSFO). (2) To analyze demographic and clinical factors associated with ...περισσότερα »

Systematic Review and Meta-analysis of Surgical Complications Following Cochlear Implantation in Canal Wall Down Mastoid Cavities.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Systematic Review and Meta-analysis of Surgical Complications Following Cochlear Implantation in Canal Wall Down Mastoid Cavities.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Hunter JB, O'Connell BP, Wanna GB Abstract OBJECTIVE: We sought to assess the complication rates following cochlear implantation in canal wall down mastoid cavities in adults and children. DATA SOURCES: A systematic review of English articles from PubMed, Web of Science, EMBASE, and the Cochrane Library. Additional studies were identified by reviewing the reference lists of the originally identified s... περισσότερα »

Sustained Inner Ear Steroid Delivery via Bioabsorbable Stent: A Tolerability and Feasibility Study on Guinea Pigs.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Sustained Inner Ear Steroid Delivery via Bioabsorbable Stent: A Tolerability and Feasibility Study on Guinea Pigs.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Lavigne P, Lavigne F, Saliba I Abstract OBJECTIVE: To determine the feasibility and tolerability of a steroid-eluting middle ear device on an animal model. STUDY DESIGN: Prospective experimental. SETTING: Experimental animal study. SUBJECTS AND METHOD: Mometasone furoate (MF)-eluting miniature sticks were implanted through a myringotomy incision into the middle ear of 10 guinea pigs. Two additional ears of 2 animals s... περισσότερα »

Pathologic Findings of the Cochlea in Labyrinthitis Ossificans Associated with the Round Window Membrane.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Pathologic Findings of the Cochlea in Labyrinthitis Ossificans Associated with the Round Window Membrane.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Kaya S, Paparella MM, Cureoglu S Abstract OBJECTIVE: To quantitatively demonstrate and classify the histopathologic changes in the cochlea of the human temporal bones with labyrinthitis ossificans (LO). STUDY DESIGN: Comparative human temporal bone study. SETTING: Tertiary academic medical center. SUBJECTS AND METHODS: We compared 23 temporal bone specimens from 19 deceased donors with LO associated with the round window membr... περισσότερα »

Information, Vol. 7, Pages 29: Measuring Knowledge Management Performance in Organizations: An Integrative Framework of Balanced Scorecard and Fuzzy Evaluation

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
As an important part of knowledge management (KM), the KM performance evaluation tries to find out the key factors restraining the enhancement of the enterprises' performance. This paper investigates the feasibility of the balanced scorecard (BSC) method in enterprise knowledge management and then proposes a simplified and applicable performance evaluation model based on the BSC approach. Finally, fuzzy comprehensive evaluation (FCE) is used to evaluate the effectiveness and applicability of the proposed model. The result shows that the model is useful for evaluating the performanc... περισσότερα »

Remote Sensing, Vol. 8, Pages 449: MERIS Phytoplankton Time Series Products from the SW Iberian Peninsula (Sagres) Using Seasonal-Trend Decomposition Based on Loess

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: ag] The European Space Agency has acquired 10 years of data on the temporal and spatial distribution of phytoplankton biomass from the MEdium Resolution Imaging Spectrometer (MERIS) sensor for ocean color. The phytoplankton biomass was estimated with the MERIS product Algal Pigment Index 1 (API 1). Seasonal-Trend decomposition of time series based on Loess (STL) identified the temporal variability of the dynamical features in the MERIS products for water leaving reflectance (ρw(λ)) and API 1. The advantages of STL is that it can identify seasonal components changing over ti... περισσότερα »

Energies, Vol. 9, Pages 411: Simultaneous Optimization of Topology and Component Sizes for Double Planetary Gear Hybrid Powertrains

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Hybrid powertrain technologies are successful in the passenger car market and have been actively developed in recent years. Optimal topology selection, component sizing, and controls are required for competitive hybrid vehicles, as multiple goals must be considered simultaneously: fuel efficiency, emissions, performance, and cost. Most of the previous studies explored these three design dimensions separately. In this paper, two novel frameworks combining these three design dimensions together are presented and compared. One approach is nested optimization which searches through th...περισσότερα »

Metals, Vol. 6, Pages 127: The Effects of Al and Ti Additions on the Structural Stability, Mechanical and Electronic Properties of D8m-Structured Ta5Si3

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: ag] In the present study, the influence of substitutional elements (Ti and Al) on the structural stability, mechanical properties, electronic properties and Debye temperature of Ta5Si3 with a D8m structure were investigated by first principle calculations. The Ta5Si3 alloyed with Ti and Al shows negative values of formation enthalpies, indicating that these compounds are energetically stable. Based on the values of formation enthalpies, Ti exhibits a preferential occupying the Ta4b site and Al has a strong site preference for the Si8h site. From the values of the bulk modul... περισσότερα »

Incidence and Risk Factors for Prolonged Hospitalization and Readmission after Transsphenoidal Pituitary Surgery.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Incidence and Risk Factors for Prolonged Hospitalization and Readmission after Transsphenoidal Pituitary Surgery.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Bur AM, Brant JA, Newman JG, Hatten KM, Cannady SB, Fischer JP, Lee JY, Adappa ND Abstract OBJECTIVE: To evaluate the incidence and factors associated with 30-day readmission and to analyze risk factors for prolonged hospital length of stay following transsphenoidal pituitary surgery. STUDY DESIGN: Retrospective longitudinal claims analysis. SETTING: American College of Surgeons National Surgical Quality Improvement P... περισσότερα »

Lymph Node Density in Node-Positive Laryngeal Carcinoma: Analysis of Prognostic Value for Survival.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Lymph Node Density in Node-Positive Laryngeal Carcinoma: Analysis of Prognostic Value for Survival.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Imre A, Pinar E, Dincer E, Ozkul Y, Aslan H, Songu M, Tatar B, Onur I, Ozturkcan S, Aladag I Abstract OBJECTIVE: We investigated the value of lymph node density (LND) as a predictor of survival in patients with laryngeal squamous cell carcinoma (SCC) and positive neck node (pN+) after laryngectomy. STUDY DESIGN: Case series with chart review. SETTING: Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey. SU...περισσότερα »

Retrosternal Goiter: 30-Day Morbidity and Mortality in the Transcervical and Transthoracic Approaches.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Retrosternal Goiter: 30-Day Morbidity and Mortality in the Transcervical and Transthoracic Approaches.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Khan MN, Goljo E, Owen R, Park RC, Yao M, Miles BA Abstract OBJECTIVE: Retrosternal goiters pose a significant challenge in determining the indications and appropriate approach for surgical removal while limiting postoperative morbidity and mortality. The objective of this study is to use the National Surgical Quality Improvement Program (NSQIP) database to compare outcomes of transcervical and transthoracic approaches for retr...περισσότερα »

Mobile Endoscopy vs Video Tower: A Prospective Comparison of Video Quality and Diagnostic Accuracy.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Mobile Endoscopy vs Video Tower: A Prospective Comparison of Video Quality and Diagnostic Accuracy.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Liu H, Akiki S, Barrowman NJ, Bromwich M Abstract OBJECTIVE: To determine if any significant difference exists between endoscopic videos captured with a mobile adaptor and videos captured with a traditional tower. STUDY DESIGN: Prospective controlled blinded comparison of mobile endoscopic videos captured through 2 methods. METHODS: Thirty randomly selected patients underwent video endoscopy with both mobile and video tower recordi... περισσότερα »

MRI- and CT-Compatible Polymer Laryngoscope: A Step toward Image-Guided Transoral Surgery.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*MRI- and CT-Compatible Polymer Laryngoscope: A Step toward Image-Guided Transoral Surgery.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Paydarfar JA, Wu X, Halter RJ PMID: 27221570 [PubMed - as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/1Uf7I4J via IFTTT

Reflections: Volunteering at Home.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Reflections: Volunteering at Home.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Hu A Abstract Many young people look forward to volunteering abroad and overlook the ample volunteer opportunities at home. There are several advantages to volunteering at home: you help people in your own community; you can make a long-term commitment; and you have continuity of care for your patients. There are &gt;1200 free clinics in the United States whose main goal is to provide care to the indigent population. These free clinics are always looking for volunteers with specialized medical tra...περισσότερα »

Anterolateral Advancement Pharyngoplasty: A New Technique for Treatment of Obstructive Sleep Apnea.

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngolgy NewsΠριν από 1 ώρα
*Anterolateral Advancement Pharyngoplasty: A New Technique for Treatment of Obstructive Sleep Apnea.* Otolaryngol Head Neck Surg. 2016 May 24; Authors: Emara TA, Hassan MH, Mohamad AS, Anany AM, Ebrahem AE Abstract OBJECTIVE: To investigate the efficacy of anterolateral advancement pharyngoplasty to enlarge pharyngeal airspace and to decrease palatal and lateral pharyngeal wall collapse in the treatment of obstructive sleep apnea (OSA). STUDY DESIGN: Prospective study. SETTING: University medical hospital. SUBJECTS AND METHOD: Forty-one patients underwent an anterolateral advancem... περισσότερα »

Microarrays, Vol. 5, Pages 11: Living Cell Microarrays: An Overview of Concepts

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: ag] Living cell microarrays are a highly efficient cellular screening system. Due to the low number of cells required per spot, cell microarrays enable the use of primary and stem cells and provide resolution close to the single-cell level. Apart from a variety of conventional static designs, microfluidic microarray systems have also been established. An alternative format is a microarray consisting of three-dimensional cell constructs ranging from cell spheroids to cells encapsulated in hydrogel. These systems provide an in vivo-like microenvironment and are preferably use... περισσότερα »

Aerospace, Vol. 3, Pages 15: Theoretical and Numerical Modeling of Acoustic Metamaterials for Aeroacoustic Applications

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: ag] The advent, during the first decade of the 21st century, of the concept of acoustic metamaterial has disclosed an incredible potential of development for breakthrough technologies. Unfortunately, the extension of the same concepts to aeroacoustics has turned out to be not a trivial task, because of the different structure of the governing equations, characterized by the presence of the background aerodynamic convection. Some of the approaches recently introduced to circumvent the problem are biased by a fundamental assumption that makes the actual realization of devices... περισσότερα »

Universe, Vol. 2, Pages 8: Black Holes and Exotic Spinors

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Exotic spin structures are non-trivial liftings, of the orthogonal bundle to the spin bundle, on orientable manifolds that admit spin structures according to the celebrated Geroch theorem. Exotic spin structures play a role of paramount importance in different areas of physics, from quantum field theory, in particular at Planck length scales, to gravity, and in cosmological scales. Here, we introduce an in-depth panorama in this field, providing black hole physics as the fount of spacetime exoticness. Black holes are then studied as the generators of a non-trivial topology that al... περισσότερα »

Atmosphere, Vol. 7, Pages 75: Stratospheric Aerosols from Major Volcanic Eruptions: A Composition-Climate Model Study of the Aerosol Cloud Dispersal and e-folding Time

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Large explosive volcanic eruptions are capable of injecting considerable amounts of particles and sulfur gases above the tropopause, causing large increases in stratospheric aerosols. Five major volcanic eruptions after 1960 (i.e., Agung, St. Helens, El Chichón, Nevado del Ruiz and Pinatubo) have been considered in a numerical study conducted with a composition-climate coupled model including an aerosol microphysics code for aerosol formation and growth. Model results are compared between an ensemble of numerical simulations including volcanic aerosols and their radiative effects ...περισσότερα »

IJMS, Vol. 17, Pages 809: The miRacle in Pancreatic Cancer by miRNAs: Tiny Angels or Devils in Disease Progression

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: ag] Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with increasing incidence and high mortality. Surgical resection is the only potentially curative treatment of patients with PDAC. Because of the late presentation of the disease, about 20 percent of patients are candidates for this treatment. The average survival of resected patients is between 12 and 20 months, with a high probability of relapse. Standard chemo and radiation therapies do not offer significant improvement of the survival of these patients. Furthermore, novel treatment options aimed at ... περισσότερα »

Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Manganese is a vital nutrient and is maintained at an optimal level (2.5–5 mg/day) in human body. Chronic exposure to manganese is associated with neurotoxicity and correlated with the development of various neurological disorders such as Parkinson's disease. Oxidative stress mediated apoptotic cell death has been well established mechanism in manganese induced toxicity. Oxidative stress has a potential to alter the epigenetic mechanism of gene regulation. Epigenetic insight of manganese neurotoxicity in context of its correlation with the development of parkinsonism is poorly und... περισσότερα »

Fibers, Vol. 4, Pages 18: Glass Fibre Strength—A Review with Relation to Composite Recycling

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
The recovery and reuse of glass fibres from manufacturing waste and end-of-life composites in an environmentally-friendly, cost-effective manner is one of the most important challenges facing the thermosetting polymer composites industry. A number of processes for recycling fibres from such materials are available or under development. However, nearly all options deliver recycled glass fibres that are not cost-performance competitive due to the huge drop in strength of recycled glass fibre compared to its original state. A breakthrough in the regeneration of recycled glass fibre p... περισσότερα »

Sustainability, Vol. 8, Pages 502: The Environmental Impact and Cost Analysis of Concrete Mixing Blast Furnace Slag Containing Titanium Gypsum and Sludge in South Korea

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
This study assessed the environmental effects and cost of the Industrial Waste addictive Blast Furnace Slag (W-BFS) using Life Cycle Assessment (LCA) and compared it to general BFS. The environmental impacts of W-BFS were as follows: 1.12 × 10−1 kg-CO2 eq/kg, 3.18 × 10−5 kg-Ethylene eq/kg, 4.79 × 10−4 kg-SO2 eq/kg, 7.15 × 10−4 kg-PO43− eq/kg, 7.15 × 10−4 kg-CFC11 eq/kg and 3.94 × 10−3 kg-Antimony eq/kg. Among the environmental impact category, GWP and AP were 9.28 × 10−2 kg-CO2 eq/kg and 3.33 × 10−4 kg-SO2 eq/kg at a raw material stage, accounting for 80% and 70% of total environm... περισσότερα »

Sustainability, Vol. 8, Pages 508: Impact of International Oil Price on Energy Conservation and Emission Reduction in China

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
In the context of "new normal" economy and frequent "haze", the strategy of energy conservation and emission reduction aiming to lower costs and reduce pollution is currently still a major strategic direction in China and the world, and will remain so for some time in the future. This paper uses the annual data of West Texas Intermediate (WTI) crude oil price in 1987–2014 as samples. We firstly present the direction and mechanism of the influence of oil price change on total consumption of every kind of energy by path analysis, and then consider establishing a Structural Vector Aut... περισσότερα »

IJERPH, Vol. 13, Pages 534: Dissipation and Residues of Dichlorprop-P and Bentazone in Wheat-Field Ecosystem

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Dichlorprop-P and bentazone have been widely used in the prevention and control of weeds in wheat field ecosystems. There is a concern that pesticide residues and metabolites remain on or in the wheat. Thus, the study of the determination and monitoring of their residues in wheat has important significance. A rapid, simple and reliable QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method was modified, developed and validated for the determination of dichlorprop-P, bentazone and its metabolites (6-hydroxy-bentazone and 8-hydroxy-bentazone) in wheat (wheat plants, wheat ...περισσότερα »

Energies, Vol. 9, Pages 410: Development of a Novel Bidirectional DC/DC Converter Topology with High Voltage Conversion Ratio for Electric Vehicles and DC-Microgrids

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
The main objective of this paper was to study a bidirectional direct current to direct current converter (BDC) topology with a high voltage conversion ratio for electric vehicle (EV) batteries connected to a dc-microgrid system. In this study, an unregulated level converter (ULC) cascaded with a two-phase interleaved buck-boost charge-pump converter (IBCPC) is introduced to achieve a high conversion ratio with a simpler control circuit. In discharge state, the topology acts as a two-stage voltage-doubler boost converter to achieve high step-up conversion ratio (48 V to 385 V). In ... περισσότερα »

Sensors, Vol. 16, Pages 759: Computer-Aided Sensor Development Focused on Security Issues

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: ag] The paper examines intelligent sensor and sensor system development according to the Common Criteria methodology, which is the basic security assurance methodology for IT products and systems. The paper presents how the development process can be supported by software tools, design patterns and knowledge engineering. The automation of this process brings cost-, quality-, and time-related advantages, because the most difficult and most laborious activities are software-supported and the design reusability is growing. The paper includes a short introduction to the Common ...περισσότερα »

Applied Sciences, Vol. 6, Pages 161: Isolation, Identification, and Biotransformation of Teadenol A from Solid State Fermentation of Pu-erh Tea and In Vitro Antioxidant Activity

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: ag] Post-fermented Pu-erh tea (PFPT) has several health benefits, however, little is known about the bioactive compounds. In this study, a PFPT compound was isolated by column chromatography and identified as Teadenol A by spectroscopic data analyses, including mass spectrometry and 1D and 2D NMR spectroscopy. Teadenol A in tea leaves was biotransformed by Aspergillus niger and A. tamari at 28 °C for 14 d at concentrations ranging from 9.85 ± 1.17 to 12.93 ± 0.38 mg/g. Additionally, the compound was detected in 22 commercial PFPTs at concentrations ranging from 0.17 ± 0.1 ... περισσότερα »

Energies, Vol. 9, Pages 412: Analytical Model for Voltage-Dependent Photo and Dark Currents in Bulk Heterojunction Organic Solar Cells

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
A physics-based explicit mathematical model for the external voltage-dependent forward dark current in bulk heterojunction (BHJ) organic solar cells is developed by considering Shockley-Read-Hall (SRH) recombination and solving the continuity equations for both electrons and holes. An analytical model for the external voltage-dependent photocurrent in BHJ organic solar cells is also proposed by incorporating exponential photon absorption, dissociation efficiency of bound electron-hole pairs (EHPs), carrier trapping, and carrier drift and diffusion in the photon absorption layer. M... περισσότερα »

JMSE, Vol. 4, Pages 37: Quantitative Estimates of Bio-Remodeling on Coastal Rock Surfaces

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: ag] Remodeling of rocky coasts and erosion rates have been widely studied in past years, but not all the involved processes acting over rocks surface have been quantitatively evaluated yet. The first goal of this paper is to revise the different methodologies employed in the quantification of the effect of biotic agents on rocks exposed to coastal morphologic agents, comparing their efficiency. Secondly, we focus on geological methods to assess and quantify bio-remodeling, presenting some case studies in an area of the Mediterranean Sea in which different geological methods... περισσότερα »

Sustainability, Vol. 8, Pages 507: Quantitative Study on the Dynamic Mechanism of Smart Low-Carbon City Development in China

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
With the development of new generation technology and the low-carbon economy, the smart low-carbon city has become one of the academic hotspots. Many studies on it have begun; however, the dynamic mechanism is rarely involved. Therefore, this paper uses the Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS) method to creatively take a quantitative study on a Chinese smart low-carbon city's dynamic mechanism. The results show that: (1) the three main dynamics of smart low-carbon city development in China are institutional and cultural conditions, facilities ...περισσότερα »

Algorithms, Vol. 9, Pages 36: Robust Hessian Locally Linear Embedding Techniques for High-Dimensional Data

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Recently manifold learning has received extensive interest in the community of pattern recognition. Despite their appealing properties, most manifold learning algorithms are not robust in practical applications. In this paper, we address this problem in the context of the Hessian locally linear embedding (HLLE) algorithm and propose a more robust method, called RHLLE, which aims to be robust against both outliers and noise in the data. Specifically, we first propose a fast outlier detection method for high-dimensional datasets. Then, we employ a local smoothing method to reduce no... περισσότερα »

Risks, Vol. 4, Pages 16: Spouses’ Dependence across Generations and Pricing Impact on Reversionary Annuities

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
This paper studies the dependence between coupled lives, i.e., the spouses' dependence, across different generations, and its effects on prices of reversionary annuities in the presence of longevity risk. Longevity risk is represented via a stochastic mortality intensity. We find that a generation-based model is important, since spouses' dependence decreases when passing from older generations to younger generations. The independence assumption produces quantifiable mispricing of reversionary annuities, with different effects on different generations. The research is conducted usi... περισσότερα »

Tailored message interventions versus typical messages for increasing participation in colorectal cancer screening among a non-adherent population: A randomized controlled trial

Αλέξανδρος ΣφακιανάκηςστοMedicine by Alexandros G.SfakianakisΠριν από 1 ώρα
BMC Public Health from #Medicine via ola Kala on Inoreader http://ift.tt/1TY9u7J via IFTTT

Unnecessary Emergency Transfers for Evaluation by a Plastic Surgeon: A Burden to Patients and the Health Care System

Background: Plastic surgeons are frequently consulted for hand and facial injuries, and patients are often transferred to trauma centers for evaluation of these problems. The authors sought to identify the frequency and impact of “unnecessary” transfers for emergency evaluation by a plastic surgeon at a Level I trauma center. Methods: The authors reviewed more than […]

Breast Cancer–Related Lymphedema: Quality of Life after Lymph Node Transfer

Background: Breast cancer–related lymphedema affects multiple aspects of patients’ daily lives. The main aim of this study was to assess the impact of vascularized lymph node transfer on the quality of life in patients with lymphedema. Methods: Between 2007 and 2012, 25 female patients with breast cancer–related lymphedema underwent vascularized lymph node transfer. In 22 […]

Effect of Cooling on Free Flap Ischemia

No abstract available from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TFVu5i via IFTTT

Clinical Significance of Internal Mammary Lymph Node Biopsy during Microsurgical Breast Reconstruction: Review of 264 Cases

Background: Despite the knowledge of alternate lymphatic draining patterns of the breast, routine evaluation of the internal mammary lymph node basin is still not considered standard of care. The advent of microsurgical breast reconstruction using the internal mammary vessels as recipients, however, has allowed sampling of internal mammary lymph nodes with technical ease, thus revisiting […]

Plastic Surgery Complete: The Clinical Masters of PRS Breast eBooks

No abstract available from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/27TtcM3 via IFTTT

Breast Reconstruction with SIEA Flaps: A Single-Institution Experience with 145 Free Flaps

Background: Refinements in microsurgical breast reconstruction have refined superficial inferior epigastric artery (SIEA) and superficial circumflex iliac artery (SCIA) flaps, yet technical difficulties and varied success rates limit widespread acceptance. The authors present the outcomes of their experience with 145 consecutive SIEA/SCIA flaps and suggest technical tips to improve success with this important flap. Methods: […]

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