Squamous Cell Atypia
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Squamous Cell Atypia Suggesting Highgrade LesionsCorrelation ofMorphological Data HPV Test Results andFollowup: Alameda F1,2*, Hernández E1, Del Amo E1,2, Bellosillo B1,3, Serrano L1 and Carreras R1,2 1Department of Pathology, and Obstetrics and Gynecology, Hospital del Mar, Barcelona, Spain 2Autonomous University of Barcelona, Spain 3Pompeu Fabra University, Barcelona Catalonia, Spain *Corresponding Author : Alameda FDepartment of Pathologyc/Passeig […]
Dysplasia in Oral Pemphigus Vulgaris
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris: A Potential Diagnostic Challenge: This report describes the management of an unusual case of oral pemphigus vulgaris (PV). The patient was referred for a painful single bullous lesion together with a small proliferative area localized in the soft palate. Histology and direct immunofluorescence […]
Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 3 δευτερόλεπτα
Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space: Dirofilariasis is caused by filarial nematodes (roundworms) of the genus Dirofilaria. Dirofilariasis of the oral mucosa is very rare. Herein, we report a case of a 79-year-old man who had a slowly growing infiltrative mass in the right buccal space. Histopathologic examination showed an […]
Spatio-temporal models to estimate daily concentrations of fine particulate matter in Montreal: Kriging with external drift and inverse distance-weighted approaches
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Spatio-temporal models to estimate daily concentrations of fine particulate matter in Montreal: Kriging with external drift and inverse distance-weighted approaches* Journal of Exposure Science and Environmental Epidemiology 26, 405 (July/August 2016). doi:10.1038/jes.2015.79 Authors: Yuddy Ramos, Benoît St-Onge, Jean-Pierre Blanchet & Audrey Smargiassi http://ift.tt/21nKZpz
Time–location patterns of a diverse population of older adults: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Time–location patterns of a diverse population of older adults: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)* Journal of Exposure Science and Environmental Epidemiology 26, 349 (July/August 2016). doi:10.1038/jes.2015.29 Authors: Elizabeth W Spalt, Cynthia L Curl, Ryan W Allen, Martin Cohen, Sara D Adar, Karen H Stukovsky, Ed Avol, Cecilia Castro-Diehl, Cathy Nunn, Karen Mancera-Cuevas & Joel D Kaufman http://ift.tt/28GqeuE
Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)* Journal of Exposure Science and Environmental Epidemiology 26, 435 (July/August 2016). doi:10.1038/jes.2016.12 Authors: Elizabeth W Spalt, Cynthia L Curl, Ryan W Allen, Martin Cohen, Kayleen Williams, Jana A Hirsch, Sara D Adar & Joel D Kaufman http://ift.tt/21nKhJ0
Using smartphones to collect time–activity data for long-term personal-level air pollution exposure assessment
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Using smartphones to collect time–activity data for long-term personal-level air pollution exposure assessment* Journal of Exposure Science and Environmental Epidemiology 26, 356 (July/August 2016). doi:10.1038/jes.2014.78 Authors: Mark L Glasgow, Carole B Rudra, Eun-Hye Yoo, Murat Demirbas, Joel Merriman, Pramod Nayak, Christina Crabtree-Ide, Adam A Szpiro, Atri Rudra, Jean Wactawski-Wende & Lina Mu http://ift.tt/28GohP2
Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Maternal exposure to air pollutant PM2.5 and PM10 during pregnancy and risk of congenital heart defects* Journal of Exposure Science and Environmental Epidemiology 26, 422 (July/August 2016). doi:10.1038/jes.2016.1 Authors: Bin Zhang, Shengwen Liang, Jinzhu Zhao, Zhengmin Qian, Bryan A Bassig, Rong Yang, Yiming Zhang, Ke Hu, Shunqing Xu, Tongzhang Zheng & Shaoping Yang http://ift.tt/21nKj3j
Spatial variation in inversion-focused vs 24-h integrated samples of PM2.5 and black carbon across Pittsburgh, PA
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Spatial variation in inversion-focused vs 24-h integrated samples of PM2.5 and black carbon across Pittsburgh, PA* Journal of Exposure Science and Environmental Epidemiology 26, 365 (July/August 2016). doi:10.1038/jes.2015.14 Authors: Brett J Tunno, Drew R Michanowicz, Jessie L C Shmool, Ellen Kinnee, Leah Cambal, Sheila Tripathy, Sara Gillooly, Courtney Roper, Lauren Chubb & Jane E Clougherty http://ift.tt/28GoFwS
Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Factors influencing time-location patterns and their impact on estimates of exposure: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)* Journal of Exposure Science and Environmental Epidemiology 26, 341 (July/August 2016). doi:10.1038/jes.2015.26 Authors: Elizabeth W Spalt, Cynthia L Curl, Ryan W Allen, Martin Cohen, Kayleen Williams, Jana A Hirsch, Sara D Adar & Joel D Kaufman http://ift.tt/21nKoUV
Spatiotemporal prediction of fine particulate matter using high-resolution satellite images in the Southeastern US 2003–2011
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Spatiotemporal prediction of fine particulate matter using high-resolution satellite images in the Southeastern US 2003–2011* Journal of Exposure Science and Environmental Epidemiology 26, 377 (July/August 2016). doi:10.1038/jes.2015.41 Authors: Mihye Lee, Itai Kloog, Alexandra Chudnovsky, Alexei Lyapustin, Yujie Wang, Steven Melly, Brent Coull, Petros Koutrakis & Joel Schwartz http://ift.tt/28Go6Do
Fine particles, genetic pathways, and markers of inflammation and endothelial dysfunction: Analysis on particulate species and sources
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Fine particles, genetic pathways, and markers of inflammation and endothelial dysfunction: Analysis on particulate species and sources* Journal of Exposure Science and Environmental Epidemiology 26, 415 (July/August 2016). doi:10.1038/jes.2015.83 Authors: Lingzhen Dai, Marie-Abele Bind, Petros Koutrakis, Brent A Coull, David Sparrow, Pantel S Vokonas & Joel D Schwartz http://ift.tt/21nLksi
Spatial patterning in PM2.5 constituents under an inversion-focused sampling design across an urban area of complex terrain
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Spatial patterning in PM2.5 constituents under an inversion-focused sampling design across an urban area of complex terrain* Journal of Exposure Science and Environmental Epidemiology 26, 385 (July/August 2016). doi:10.1038/jes.2015.59 Authors: Brett J Tunno, Rebecca Dalton, Drew R Michanowicz, Jessie L C Shmool, Ellen Kinnee, Sheila Tripathy, Leah Cambal & Jane E Clougherty http://ift.tt/28GnLk5
Residential mobility impacts exposure assessment and community socioeconomic characteristics in longitudinal epidemiology studies
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Residential mobility impacts exposure assessment and community socioeconomic characteristics in longitudinal epidemiology studies* Journal of Exposure Science and Environmental Epidemiology 26, 428 (July/August 2016). doi:10.1038/jes.2016.10 Authors: Cole Brokamp, Grace K LeMasters & Patrick H Ryan http://ift.tt/21nLj7A
The Fort Collins Commuter Study: Impact of route type and transport mode on personal exposure to multiple air pollutants
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*The Fort Collins Commuter Study: Impact of route type and transport mode on personal exposure to multiple air pollutants* Journal of Exposure Science and Environmental Epidemiology 26, 397 (July/August 2016). doi:10.1038/jes.2015.68 Authors: Nicholas Good, Anna Mölter, Charis Ackerson, Annette Bachand, Taylor Carpenter, Maggie L Clark, Kristen M Fedak, Ashleigh Kayne, Kirsten Koehler, Brianna Moore, Christian L'Orange, Casey Quinn, Viney Ugave, Amy L Stuart, Jennifer L Peel & John Volckens http://ift.tt/28GoeTm
Time-location patterns of a diverse population of older adults: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)
Αλέξανδρος ΣφακιανάκηςστοOccupational and Environmental Medicine by Alexandros G.SfakianakisΠριν από 7 δευτερόλεπτα
*Time-location patterns of a diverse population of older adults: the Multi-Ethnic Study of Atherosclerosis and Air Pollution (MESA Air)* Journal of Exposure Science and Environmental Epidemiology 26, 436 (July/August 2016). doi:10.1038/jes.2016.13 Authors: Elizabeth W Spalt, Cynthia L Curl, Ryan W Allen, Martin Cohen, Sara D Adar, Karen H Stukovsky, Ed Avol, Cecilia Castro-Diehl, Cathy Nunn, Karen Mancera-Cuevas & Joel D Kaufman http://ift.tt/21nKoEp
Nuclear Anomalies in Exfoliated Buccal Epithelial Cells ofShoe Workers
in Khartoum State: *Albasheer F1* and Elamin EM2* 1Alneelin university, Faculty of Medical Lab Sciences, Khartoum, Sudan 2Alzaeim Alazhari University, Faculty of Medical Lab Sciences, Khartoum, Sudan *Corresponding Author:Albasheer F Alneelin university Faculty of Medical Lab Sciences, Khartoum, Sudan *Tel:* 249912158886 *E-mail:* fadiahhisto1988@gmail.com *Citation: *Albasheer F, Elamin EM (2016) Nuclear Anomalies in Exfoliated Buccal Epithelial Cells of Shoe Workers in Khartoum State. J Cytol Histol 7:411. doi:10.4172/2157-7099.1000411 *Copyright:* © 2016 Albasheer F, et al. ... περισσότερα »
Conjunctival Dysplasia and Atypical Secondary AcquiredMelanosis inXeroderma Pigmentosum
*Conjunctival Dysplasia and Atypical Secondary AcquiredMelanosis inXeroderma Pigmentosum: * *Lim EWL1, Lim L2, Jajeh IA3* and Jayasinghe LS2,4* *1Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, Singapore* *2Corneal and External Eye Disease Service, Singapore National Eye Centre, Singapore* *3Histopathology, Pathology Department, Singapore General Hospital, Singapore* *4Department of Ophthalmology, Teaching Hospital Kandy, Sri Lanka* **Corresponding Author:* *Issam AlJajeh Pathology, Mailing address: 20 College RoadAcademia, Level 10, 1... περισσότερα »
Squamous Cell Atypia
Squamous Cell Atypia Suggesting Highgrade Lesions Correlation ofMorphological Data HPV Test Results and Followup: *Alameda F1,2*, Hernández E1, Del Amo E1,2, Bellosillo B1,3, Serrano L1 and Carreras R1,2* *1Department of Pathology, and Obstetrics and Gynecology, Hospital del Mar, Barcelona, Spain* *2Autonomous University of Barcelona, Spain* *3Pompeu Fabra University, Barcelona Catalonia, Spain* **Corresponding Author :* *Alameda FDepartment of Pathologyc/Passeig Maritim 25-2908003 Barcelona, SpainTel: +34932483919Fax: +34932483131 E-mail: falameda@hospitaldelmar.cat* *Citat... περισσότερα »
Dysplasia in Oral Pemphigus Vulgaris
Unusual Histological Evidence of Dysplasia in a Case of Oral Pemphigus Vulgaris: A Potential Diagnostic Challenge: This report describes the management of an unusual case of oral pemphigus vulgaris (PV). The patient was referred for a painful single bullous lesion together with a small proliferative area localized in the soft palate. Histology and direct immunofluorescence data were consistent for PV but disclosed unusual signs of high-grade dysplasia in the proliferative area. At surgical removal of the dysplastic area 1 week after the start of cortisone therapy there was no evide... περισσότερα »
Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space
Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space: Dirofilariasis is caused by filarial nematodes (roundworms) of the genus *Dirofilaria*. Dirofilariasis of the oral mucosa is very rare. Herein, we report a case of a 79-year-old man who had a slowly growing infiltrative mass in the right buccal space. Histopathologic examination showed an inflammatory infiltrate with eosinophilia, histiocytes, and small organisms (0.2-0.3 mm). Digital images were sent to the Centers for Disease Control and Prevention, which identified the parasite as a nematode in the genu... περισσότερα »
Noninvasive ventilation application in pressure support mode during spontaneous breathing anesthesia increased functional residual capacity
Noninvasive ventilation during spontaneous breathing anesthesia: an observational study using electrical impedance tomography: [image: gr1.sml] To assess the effects of noninvasive ventilation (NIV) during spontaneous breathing anesthesia on functional residual capacity and ventilation distribution. Highlights - •We investigate effects of noninvasive ventilation (NIV) during spontaneous breathing anesthesia. - •We used a bedside technique: electrical impedance tomography. - •NIV application in pressure support mode during spontaneous breathing anesthesia inc... περισσότερα »
Medication prescription for atopic diseases and attention-deficit/hyperactivity disorder
Association between via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online June 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Jurjen van der Schans, Janine C. Pleiter, Tjalling W. de Vries, Catharina C.M. Schuiling-Veninga, Jens H.J. Bos, Pieter J. Hoekstra, Eelko Hak BackgroundData on the association between atopic diseases and attention-deficit/hyperactivity disorder (ADHD) have been inconclusive.ObjectivesTo assess whether children with drug-treated ADHD are more likely to receive treatment for asthma, allergic rh... περισσότερα »
Common variable immunodeficiency (CVID)
Disturbed canonical NF-kB signaling in B cells of CVID patients via Allergy and Clinical Immunology Publication date: Available online 14 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Baerbel Keller, Zoltan Cseresnyes, Ina Stumpf, Claudia Wehr, Manfred Fliegauf, Alla Bulashevska, Susanne Usadel, Bodo Grimbacher, Marta Rizzi, Hermann Eibel, Raluca Niesner, Klaus Warnatz BackgroundMost patients with Common variable immunodeficiency (CVID) present with severely reduced switched memory B cells and some display an increase of CD21low B cells (CVID 21low) while oth... περισσότερα »
Skin blistering and atopic disease
Keratin-dependent TSLP expression suggests a link between skin blistering and atopic disease via Allergy and Clinical Immunology Publication date: Available online 15 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Vinod Kumar, Matthias Behr, Dimitra Kiritsi, Andrea Scheffschick, Anja Grahnert, Melanie Homberg, Agnes Schwieger-Briel, Thilo Jakob, Leena Bruckner-Tuderman, Thomas M. Magin Key words atopic dermatitis; allergy; epidermolysis bullosa simplex; keratins; itch; thymic stromal lymphopoietin (TSLP) Abbreviations AD, Atopic dermatitis; AP-1, Activating... περισσότερα »
Aspirin-Exacerbated Respiratory Disease
Eosinophil production of PGD2 in via Allergy and Clinical Immunology Publication date: Available online June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Xin Feng, Madison K. Ramsden, Julie Negri, Mary Grace Baker, Spencer C. Payne, Larry Borish, John W. Steinke BackgroundAspirin-exacerbated respiratory disease (AERD) differs from aspirin tolerant disease due in part to eosinophilic tissue infiltration and over-expression of arachidonic acid metabolic pathway components that lead to enhanced secretion of cysteinyl leukotrienes (CysLT) and prostaglandin D2 (PGD2... περισσότερα »
Anti-thyroid agents as anti-asthma drugs
The potential for repositioning via Allergy and Clinical Immunology Publication date: Available online 15 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Shoichi Suzuki, Masahiro Ogawa, Shoichiro Ohta, Kazuhiko Arima, Satoshi Nunomura, Yasuhiro Nanri, Yasutaka Mitamura, Tomohito Yoshihara, Yutaka Nakamura, Kohei Yamauchi, Kazuyuki Chibana, Yoshiki Ishii, James J. Lee, Yasuaki Aratani, Shigeru Kakuta, Sachiko Kubo, Yoichiro Iwakura, Hiroki Yoshida, Kenji Izuhara TeaserThe deleterious effects of peroxidases in asthma remain undetermined. Peroxidase inhibitors w... περισσότερα »
Rhinovirus and Serum IgE are Associated with Acute Asthma Exacerbation Severity
Rhinovirus and Serum IgE are Associated with Acute Asthma Exacerbation Severity in Children via Allergy and Clinical Immunology Publication date: Available online 15 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): David B. Kantor, Nicole Stenquist, Molly C. McDonald, Blake J. Schultz, Marissa Hauptman, Craig D. Smallwood, Kyle A. Nelson, Matthew S. Perzanowski, Elizabeth C. Matsui, Wanda Phipatanakul, Joel N. Hirschhorn TeaserA substantial portion of the inter-individual variation in acute asthma exacerbation severity is attributable to the combination of rhi... περισσότερα »
Airway Neuronal Dysfunction
Capsaicin Cough Responses in Asthma: Evidence for via Allergy and Clinical Immunology Publication date: Available online 15 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): Imran Satia, Nikolaos Tsamandouras, Kimberley Holt, Huda Badri, Mark Woodhead, Kayode Ogungbenro, Timothy W. Felton, Paul M. O’Byrne, Stephen J. Fowler, Jaclyn A. Smith BackgroundCough in asthma is a common and troublesome symptom. It is generally assumed coughing occurs as a consequence of bronchial hyper-responsiveness and inflammation, but the possibility that airway nerves are dysfuncti... περισσότερα »
Determination of metabolic changes that occur following the development of and after red meat challenge in alpha-gal allergic individuals will aid in biomarkers for patient identification and targeted therapeutic development.
Altered metabolic profile in patients with IgE to galactose-alpha-1,3-galactose following in vivo food challenge via Allergy and Clinical Immunology Publication date: Available online 15 June 2016 *Source:*Journal of Allergy and Clinical Immunology Author(s): John W. Steinke, Shawna L. Pochan, Hayley R. James, Thomas A.E. Platts-Mills, Scott P. Commins TeaserDetermination of metabolic changes that occur following the development of and after red meat challenge in alpha-gal allergic individuals will aid in biomarkers for patient identification and targeted therapeutic development.
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency via ScienceDirect Publication: Immunity Publication date: Available online June 2016 *Source:*Immunity Author(s): Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta, Hiroshi Takayanagi Sepsis is a host inflammatory response to severe infection associated with high mortality that is caused by lymphopenia-associated immunodeficiency. However, it is unknown how lymphopenia persists after the accelerated lymphocyte apoptosis subsides. Here we show that sepsis rapidly ablated osteoblasts, which reduced th... περισσότερα »
The Differentiation of Interleukin-9-Producing CD4+ T Cells
Histone Deacetylase SIRT1 Negatively Regulates via ScienceDirect Publication: Immunity Publication date: Available online June 2016 *Source:*Immunity Author(s): Yu Wang, Yujing Bi, Xi Chen, Chunxiao Li, Yan Li, Zhengguo Zhang, Jian Wang, Yun Lu, Qing Yu, Huilin Su, Hui Yang, Guangwei Liu Distinct metabolic programs support the differentiation of CD4+ T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4+ T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone... περισσότερα »
Adiponectin Enhances Antibacterial Activity
Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation via ScienceDirect Publication: Immunity Publication date: Available online June 2016 *Source:*Immunity Author(s): Yosuke Masamoto, Shunya Arai, Tomohiko Sato, Akihide Yoshimi, Naoto Kubota, Iseki Takamoto, Yoichiro Iwakura, Akihiko Yoshimura, Takashi Kadowaki, Mineo Kurokawa Obesity has been shown to increase the morbidity of infections, however, the underlying mechanisms remain largely unknown. Here we demonstrate that obesity caused adiponectin deficiency in the bone marrow (BM... περισσότερα »
T helper 17 (Th17) cells are prominently featured in multiple autoimmune diseases
The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways via ScienceDirect Publication: Immunity Publication date: Available online 14 June 2016 *Source:*Immunity Author(s): Xiang Xiao, Xiaomin Shi, Yihui Fan, Chenglin Wu, Xiaolong Zhang, Laurie Minze, Wentao Liu, Rafik M. Ghobrial, Peixiang Lan, Xian Chang Li T helper 17 (Th17) cells are prominently featured in multiple autoimmune diseases, but the regulatory mechanisms that control Th17 cell responses are poorly defined. Here we found that stimulation of OX40 tr... περισσότερα »
Viscerocutaneous Flap Prefabrication
Jejunum/DIEP Composite Flap: A Novel Rat Model of Viscerocutaneous Flap Prefabrication: J reconstr Microsurg DOI: 10.1055/s-0036-1584171 Background Reconstruction of complex pharyngoesophageal defects presents a major challenge, particularly in soft tissue deficient and previously scarred surgical sites. In recent years, the free jejunum flap method has emerged as a reliable means of esophageal reconstruction. However, it may require cutaneous coverage with an additional flap in extensively scarred, secondary reconstructions. Prefabrication of an intestinal/cutaneous composite fla... περισσότερα »
Effect of Microvascular Anastomosis Technique on End Product Outcome
in Simulated Training: A Prospective Blinded Randomized Controlled Trial: J reconstr Microsurg DOI: 10.1055/s-0036-1584218 Background The aim of this article is to evaluate the difference in skills acquisition of two end-to-end microvascular anastomosis techniques—the triangulation and biangulation—in early microsurgery training. Method In this study, 32 candidates ranging from medical students to higher surgical trainees underwent a 5-day basic microsurgery course. On days 3 and 5 of the course, candidates performed two end-to-end anastomoses on cryopreserved rat aortas. One anas... περισσότερα »
Abdominal morbidity after single-versus double-pedicled deep inferior epigastric perforator flap use
Abdominal morbidity after single-versus double-pedicled deep inferior epigastric perforator flap use: The reduced incidence of donor site morbidity after deep inferior epigastric perforator (DIEP) flap is because the rectus muscle and its fascia are preserved. However, no study has proved that trunk flexion recovers not by the compensatory effect of the contralateral rectus muscle, but by reinnervation of the ipsilateral rectus muscle. We hypothesized if sufficient reinnervation occurs, patients who undergo single-pedicled DIEP flap (S-DIEP) or double-pedicled DIEP flap (D-DIEP) bre... περισσότερα »
Balance disorders in childhood
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* pubmed: balance disorders ch... *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed in Internet Explorer and other programs. Learn more about feeds. [image: Plus Button]Subscribe to this feed [image: Feed image] Children with nocturnal e... περισσότερα »
Balance disorders in childhood
: Main etiologies according to age. Usefulness of the video head impulse test via International Journal of Pediatric Otorhinolaryngology Publication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Patricia Alejandra Sommerfleck, María Emilia González Macchi, Romina Weinschelbaum, Maximiliano Damián De Bagge, Patricia Bernáldez, Sergio Carmona Balance disorders are common in adult patients but less usual in the pediatric population. When this symptomatology appears in children it is a cause for concern, both for parents and health... περισσότερα »
Management of otitis media in preschool children
Danish guidelines on via International Journal of Pediatric Otorhinolaryngology Publication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): C.H. Heidemann, J. Lous, J. Berg, J.J. Christensen, S.J. Håkonsen, M. Jakobsen, C.J. Johansen, L.H. Nielsen, M.P. Hansen, A. Poulsen, L.P. Schousboe, C. Skrubeltang, A.B. Vind, P. Homøe IntroductionOtitis media is one of the most common diseases in small children. This underlines the importance of optimizing diagnostics and treatment of the condition. Recent literature points toward a stricte... περισσότερα »
Image-Guided Placement of Osseointegrated Implants
for Challenging Auricular, Orbital, and Rhinectomy Defects: Objectives: Prosthetic reconstruction can restore the preoperative form and function after surgery for head and neck malignancies. We demonstrate the use of preoperative planning and intraoperative image guidance for placement of osseointegrated implants to restore craniofacial defects. Methods: A retrospective review of patients with craniofacial defects treated with image-guided placement of osseointegrated prosthetic implants was performed. Results: Case 1: 55-year-old male who underwent total auriculectomy with anter... περισσότερα »
Noninvasive ventilation application in pressure support mode during spontaneous breathing anesthesia increased functional residual capacity
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Noninvasive ventilation during spontaneous breathing anesthesia: an observational study using electrical impedance tomography: To assess the effects of noninvasive ventilation (NIV) during spontaneous breathing anesthesia on functional residual capacity and ventilation distribution. Highlights •We investigate effects of noninvasive ventilation (NIV) during spontaneous breathing anesthesia. •We used a bedside technique: electrical impedance tomography. •NIV application in […]
Medication prescription for atopic diseases and attention-deficit/hyperactivity disorder
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Association between via ScienceDirect Publication: Annals of Allergy, Asthma & Immunology Publication date: Available online June 2016Source:Annals of Allergy, Asthma & ImmunologyAuthor(s): Jurjen van der Schans, Janine C. Pleiter, Tjalling W. de Vries, Catharina C.M. Schuiling-Veninga, Jens H.J. Bos, Pieter J. Hoekstra, Eelko HakBackgroundData on the association between atopic diseases and attention-deficit/hyperactivity disorder (ADHD) have been […]
Common variable immunodeficiency (CVID)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Disturbed canonical NF-kB signaling in B cells of CVID patients via Allergy and Clinical Immunology Publication date: Available online 14 June 2016Source:Journal of Allergy and Clinical ImmunologyAuthor(s): Baerbel Keller, Zoltan Cseresnyes, Ina Stumpf, Claudia Wehr, Manfred Fliegauf, Alla Bulashevska, Susanne Usadel, Bodo Grimbacher, Marta Rizzi, Hermann Eibel, Raluca Niesner, Klaus WarnatzBackgroundMost patients with Common variable immunodeficiency […]
Skin blistering and atopic disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Keratin-dependent TSLP expression suggests a link between skin blistering and atopic disease via Allergy and Clinical Immunology Publication date: Available online 15 June 2016Source:Journal of Allergy and Clinical ImmunologyAuthor(s): Vinod Kumar, Matthias Behr, Dimitra Kiritsi, Andrea Scheffschick, Anja Grahnert, Melanie Homberg, Agnes Schwieger-Briel, Thilo Jakob, Leena Bruckner-Tuderman, Thomas M. Magin Key wordsatopic dermatitis; allergy; epidermolysis bullosa […]
Aspirin-Exacerbated Respiratory Disease
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Eosinophil production of PGD2 in via Allergy and Clinical Immunology Publication date: Available online June 2016Source:Journal of Allergy and Clinical ImmunologyAuthor(s): Xin Feng, Madison K. Ramsden, Julie Negri, Mary Grace Baker, Spencer C. Payne, Larry Borish, John W. SteinkeBackgroundAspirin-exacerbated respiratory disease (AERD) differs from aspirin tolerant disease due in part to eosinophilic tissue infiltration and over-expression […]
Anti-thyroid agents as anti-asthma drugs
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
The potential for repositioning via Allergy and Clinical Immunology Publication date: Available online 15 June 2016Source:Journal of Allergy and Clinical ImmunologyAuthor(s): Shoichi Suzuki, Masahiro Ogawa, Shoichiro Ohta, Kazuhiko Arima, Satoshi Nunomura, Yasuhiro Nanri, Yasutaka Mitamura, Tomohito Yoshihara, Yutaka Nakamura, Kohei Yamauchi, Kazuyuki Chibana, Yoshiki Ishii, James J. Lee, Yasuaki Aratani, Shigeru Kakuta, Sachiko Kubo, Yoichiro Iwakura, […]
Rhinovirus and Serum IgE are Associated with Acute Asthma Exacerbation Severity
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Rhinovirus and Serum IgE are Associated with Acute Asthma Exacerbation Severity in Children via Allergy and Clinical Immunology Publication date: Available online 15 June 2016Source:Journal of Allergy and Clinical ImmunologyAuthor(s): David B. Kantor, Nicole Stenquist, Molly C. McDonald, Blake J. Schultz, Marissa Hauptman, Craig D. Smallwood, Kyle A. Nelson, Matthew S. Perzanowski, Elizabeth C. Matsui, Wanda […]
Airway Neuronal Dysfunction
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Capsaicin Cough Responses in Asthma: Evidence for via Allergy and Clinical Immunology Publication date: Available online 15 June 2016Source:Journal of Allergy and Clinical ImmunologyAuthor(s): Imran Satia, Nikolaos Tsamandouras, Kimberley Holt, Huda Badri, Mark Woodhead, Kayode Ogungbenro, Timothy W. Felton, Paul M. O’Byrne, Stephen J. Fowler, Jaclyn A. SmithBackgroundCough in asthma is a common and troublesome symptom. […]
Determination of metabolic changes that occur following the development of and after red meat challenge in alpha-gal allergic individuals will aid in biomarkers for patient identification and targeted therapeutic development.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Altered metabolic profile in patients with IgE to galactose-alpha-1,3-galactose following in vivo food challenge via Allergy and Clinical Immunology Publication date: Available online 15 June 2016Source:Journal of Allergy and Clinical ImmunologyAuthor(s): John W. Steinke, Shawna L. Pochan, Hayley R. James, Thomas A.E. Platts-Mills, Scott P. Commins Teaser Determination of metabolic changes that occur following the development […]
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 17 δευτερόλεπτα
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency via ScienceDirect Publication: Immunity Publication date: Available online June 2016Source:ImmunityAuthor(s): Asuka Terashima, Kazuo Okamoto, Tomoki Nakashima, Shizuo Akira, Koichi Ikuta, Hiroshi TakayanagiSepsis is a host inflammatory response to severe infection associated with high mortality that is caused by lymphopenia-associated immunodeficiency. However, it is unknown how lymphopenia persists after the accelerated lymphocyte […]
Chemotherapy (platinum and pemetrexed) in combination with erlotinib in non-small cell lung cancer induces major gastrointestinal toxicity: two case reports from the FLARE/GFPC 03-2013 study
Summary What is known and objective A randomized phase III study was designed to assess the efficacy and safety of second-line platinum-based chemotherapy with or without erlotinib in non-small cell lung cancer (NSCLC) with EGFR-activating mutation after secondary resistance to EGFR-TKIs (epidermal growth factor receptor tyrosine kinase inhibitors). Case summary We report herein two of the first three patients who presented with major gastrointestinal toxicities in the experimental arm of the trial. What is new and conclusion Pending further data, it would seem safer to administ... περισσότερα »
Oncogenic and Tumor Suppressor Roles of PTK6 in Colon Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Disruption of the gene encoding Protein Tyrosine Kinase 6 (Ptk6) delayed differentiation and increased growth in the mouse intestine. However, Ptk6-null mice were also resistant to azoxymethane-induced colon tumorigenesis. To further explore functions of PTK6 in colon cancer, expression of epithelial and mesenchymal markers, as well as proliferation, migration, and xenograft tumor growth, was examined […]
c-MET CTC Platform for GI and GU Malignancies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Amplification of the MET oncogene is associated with poor prognosis, metastatic dissemination, and drug resistance in many malignancies. We developed a method to capture and characterize circulating tumor cells (CTC) expressing c-MET using a ferromagnetic antibody. Immunofluorescence was used to characterize cells for c-MET, DAPI, and pan-CK, excluding CD45+ leukocytes. The assay was validated using […]
APA in Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Advancements in sequencing and transcriptome analysis methods have led to seminal discoveries that have begun to unravel the complexity of cancer. These studies are paving the way toward the development of improved diagnostics, prognostic predictions, and targeted treatment options. However, it is clear that pieces of the cancer puzzle are still missing. In an effort […]
Selected Articles from This Issue
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1UwMcdm via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Targeting CX3CR1 Reduces Breast Cancer Metastasis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Recent evidence indicates that cancer cells, even in the absence of a primary tumor, recirculate from established secondary lesions to further seed and colonize skeleton and soft tissues, thus expanding metastatic dissemination and precipitating the clinical progression to terminal disease. Recently, we reported that breast cancer cells utilize the chemokine receptor CX3CR1 to exit the […]
Dual Role of miR-146a in Tumor Progression
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Malignant melanoma is the most aggressive form of skin cancer; therefore, it is crucial to disclose its underlying molecular mechanisms. MicroRNAs (miRNAs) are small endogenous noncoding RNAs able to posttranscriptionally downregulate the expression of direct target genes. Using a melanoma progression model, miR-146a was identified as a key double-acting player in melanoma malignancy. In fact, […]
GRHL2 Suppresses GLUD1 Sensitizing to Anoikis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
Resistance to anoikis is a prerequisite for tumor metastasis. The epithelial-to-mesenchymal transition (EMT) allows tumor cells to evade anoikis. The wound-healing regulatory transcription factor Grainyhead-like 2 (GRHL2) suppresses/reverses EMT, accompanied by suppression of the cancer stem cell (CSC) phenotype and by resensitization to anoikis. Here, the effects of GRHL2 upon intracellular metabolism in the context […]
SOCS3 and Androgen Receptor Signaling in Prostate Cancer
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 29 δευτερόλεπτα
The proinflammatory cytokine IL6 is associated with bad prognosis in prostate cancer and implicated in progression to castration resistance. Suppressor of cytokine signaling 3 (SOCS3) is an IL6-induced negative feedback regulator of the IL6/Janus kinase (JAK)/STAT3 pathway. This study reveals that the SOCS3 promoter is hypermethylated in cancerous regions compared with adjacent benign tissue in […]
Heart failure
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Heart failure: Inability of the heart to keep up with the demands on it and, specifically, failure of the heart to pump blood with normal efficiency. When this occurs, the heart is unable to provide adequate blood flow to other organs such as the brain, liver and kidneys. Heart failure may be due to failure […]
Expression of a gap junction protein, connexin43, in a large panel of human gliomas: new insights
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 31 δευτερόλεπτα
Abstract Precise diagnosis of low and high grades of brain tumors permits determining therapeutical strategies. So far, diagnosis and prognosis of gliomas were based on histological and genetic criteria which need being completed by a panel of molecular markers. Highly distributed in brain, gap junction proteins, connexins, could be considered as markers of glioma progression […]
Validating silicon polytrodes with paired juxtacellular recordings: method and dataset
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Cross-validating new methods for recording neural activity is necessary to accurately interpret and compare the signals they measure. Here we describe a procedure for precisely aligning two probes for in vivo "paired-recordings" such that the spiking activity of a single neuron is monitored with both a dense extracellular silicon polytrode and a juxtacellular micro-pipette. Our new method allows for efficient, reliable, and automated guidance of both probes to the same neural structure with micron resolution. We also describe a new dataset of paired-recordings, which is available ... περισσότερα »
Using melanopsin to study G protein signaling in cortical neurons
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Our understanding of G protein-coupled receptors in the central nervous system has been hampered by the limited availability of tools allowing for the study of their signaling with precise temporal control. To overcome this, we tested the utility of the bistable mammalian opsin melanopsin to examine G protein signaling in CNS neurons. Specifically we used biolistic (gene gun) approaches to transfect melanopsin into cortical pyramidal cells maintained in organotypic slice culture. Whole cell recordings from transfected neurons indicated that application of blue light effectively ac... περισσότερα »
Purkinje cell intrinsic excitability increases after synaptic long term depression
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Coding in cerebellar Purkinje cells not only depends on synaptic plasticity but also on their intrinsic membrane excitability. We performed whole cell patch clamp recordings of Purkinje cells in sagittal cerebellar slices in mice. We found that inducing long term depression (LTD) in the parallel fiber (PF) to Purkinje cell (PC) synapses results in an increase in the gain of the firing rate response. This increase in excitability is accompanied by an increase in the input resistance and a decrease in the amplitude of the hyperpolarization-activated cyclic nucleotide-gated (HCN) cha... περισσότερα »
Active sensing without efference copy: referent control of perception
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Although action and perception are different behaviors, they are likely to be interrelated, as implied by the notions of perception-action coupling and active sensing. Traditionally, it has been assumed that the nervous system directly pre-programs motor commands required for actions and uses a copy of them called efference copy (EC) to also influence our senses. This review offers a critical analysis of the EC concept by identifying its limitations in solving several problems of perception and action. An alternative to the EC concept is based on the experimentally confirmed notio... περισσότερα »
Human parietal cortex lesions impact the precision of spatial working memory
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
The neural mechanisms that support working memory (WM) depend on persistent neural activity. Within topographically organized maps of space in dorsal parietal cortex, spatially selective neural activity persists during WM for location. However, to date the necessity of these topographic subregions of human parietal cortex for WM remain unknown. To test the causal relationship of these areas to WM, we compared the performance of patients with lesions to topographically organized parietal cortex to controls on a memory-guided saccade (MGS) task as well as a visually-guided saccade (V... περισσότερα »
Effect of current focusing on the sensitivity of inferior colliculus neurons to amplitude modulated stimulation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
In multichannel cochlear implants (CIs), current is delivered to specific electrodes along the cochlea in the form of amplitude-modulated pulse trains, to convey temporal and spectral cues. Our previous studies have shown that focused multipolar (FMP) and tripolar (TP) stimulation produce more restricted neural activation and reduced channel interactions in the inferior colliculus (IC), compared to traditional monopolar (MP) stimulation, suggesting that focused stimulation could produce better transmission of spectral information. The present study explored the capability of IC ne... περισσότερα »
Synaptic and intrinsic homeostasis cooperate to optimize single neuron response properties and tune integrator circuits
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Homeostatic processes that provide negative feedback to regulate neuronal firing rate are essential for normal brain function, and observations suggest that multiple such processes may operate simultaneously in the same network. We pose two questions: why might a diversity of homeostatic pathways be necessary, and how can they operate in concert without opposing and undermining each other? To address these questions, we perform a computational and analytical study of cell-intrinsic homeostasis and synaptic homeostasis in single-neuron and recurrent circuit models. We demonstrate a... περισσότερα »
Distinct contributions of explicit and implicit memory processes to weight prediction when lifting objects and judging their weights: an aging study.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Weight predictions used to scale lifting forces adapt quickly when repeatedly lifting unusually weighted objects, and are readily updated by explicit information provided about weight. In contrast, weight predictions used when making perceptual judgments about weight are more resistant to change and are largely unaffected by explicit information about weight. These observations suggest that distinct memory systems underlie weight prediction when lifting objects and judging their weights. Here we examined whether these weight predictions differ in their reliance on declarative and ... περισσότερα »
In vitro characterization of noradrenergic modulation of chemosensitive neurons in the retrotrapezoid nucleus
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Chemosensitive neurons in the retrotrapezoid nucleus (RTN) regulate breathing in response to CO2/H+ changes, and serve as an integration center for other autonomic centers including brainstem noradrenergic neurons. Norepinephrine (NE) contributes to respiratory control and chemoreception, and since disruption of NE signaling may contribute to several breathing disorders; we sought to characterize effects of NE on RTN chemoreception. All neurons included in this study responded similarly to CO2/H+ but showed differential sensitivity to NE; we found that NE activated (79%), inhibited... περισσότερα »
Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long term facilitation
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Glutamatergic currents play a fundamental role in regulating respiratory motor output, and are partially mediated by α-amino-3-hydroxy-5-methyl-isoxazole-propionic acid (AMPA) receptors throughout the premotor and motor respiratory circuitry. Ampakines are pharmacological compounds that enhance glutamatergic transmission by altering AMPA receptor channel kinetics. Here we examined if ampakines alter the expression of respiratory long term facilitation (LTF), a form of neuroplasticity manifested as a persistent increase in inspiratory activity following brief periods of reduced O2 ... περισσότερα »
High Prevalence of Non-ST131 CTX-M-15-Producing Escherichia coli in Healthy Cattle in Lebanon
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Microbial Drug Resistance , Vol. 0, No. 0. from Mary Ann Liebert, Inc. publishers via xlomafota13 on Inoreader http://ift.tt/24RYAGp via IFTTT
Electromyographic changes of trunk muscles during the graded lumbar stabilization exercises
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Lumbar stabilization exercises are effective for the treatment of patients with low back pain. However, personalized exercise programs are required to facilitate more efficient treatment, as each individual exhibits the different characteristics of the trunk muscles and pain. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1OqZgR9 via IFTTT
Health Benefits of Zumba® fitness training: a systematic review
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
As an alternative to the traditional approach to physical exercise, new kinds of organized physical activity have been developed designed to engage large segments of the population. Among these, Zumba® fitness is extremely popular with a growing number of participants. This document aims to summarize and analyze the body of evidence on the effects of Zumba® fitness interventions (ZFIs) on physical function, fitness and wellbeing. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1rqQIP1 via IFTTT
Sonographic findings in subcoracoid impingement syndrome: a case report and literature review
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Subcoracoid impingement syndrome is a rare and under-recognized cause of anterior shoulder pain. Currently, subcoracoid impingement syndrome is understood to involve impingement of anatomic structures such as the subcoracoid bursa and subscapularis tendon within the coracohumeral space, and there are no reports of sonographic findings in subcoracoid impingement syndrome other than the impingement of thickened subscapularis bursa. Here we report a case of subcoracoid impingement syndrome, including a novel sonographic finding, arthroscopic findings, and a proposed pathophysiology. ... περισσότερα »
Characteristics of intratendinous microcirculation shortly after an Achilles rupture and subsequent treatment outcomes
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Early microcirculatory responses after experimental tenotomy are critical to the healing of tendons and their ultimate tensile strength. However, the effects of changes in microcirculation on the outcomes of tendon healing have not been determined. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1OqZ1Wg via IFTTT
Does the Physical Medicine and Rehabilitation Self-Assessment Examination for Residents Predict the Chances of Passing the Part 1 Board Certification Examination?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Each year, residents in accredited United States Physical Medicine and Rehabilitation (PMR) residency programs can take the American Academy of Physical Medicine and Rehabilitation (AAPM&R) Self-Assessment Examination for Residents (SAE-R). This 150 question multiple choice examination is intended for self-assessment of physiatric knowledge but its predictive value for performance on the part 1 American Board of Physical Medicine and Rehabilitation Certification Examination (ABPMR-CE) is unknown. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1rqQabY via IFTTT
Ultrasonographic Evaluation and Feasibility of Posterior Superior Internal Impingement Syndrome: A Case Series
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Posterosuperior impingement (PSI) is an underdiagnosed cause of posterior shoulder pain and should be differentiated from classic and external impingement. PSI involves the internal impingement of soft tissues, including the undersurface of the rotator cuff against the posterosuperior labrum when the arm is brought into abduction and external rotation (ABER). Ultrasonography (US) can be useful in the assessment of PSI because of its high resolution and ability to perform during dynamic maneuvers in ABER. from Rehabilitation via xlomafota13 on Inoreader http://ift.tt/1OqYeVb via IFTTT
Obstetric Provider Maldistribution: Georgia, USA, 2011
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Abstract *Objectives* In 2010, Georgia had the nation's highest maternal mortality rate, sixteenth highest infant mortality rate, and a waning obstetrician/gynecologist (ob/gyn) workforce. Statewide ob/gyn workforce data, however, masked obstetric-specific care shortages and regional variation in obstetric services. The Georgia Maternal and Infant Health Research Group thereby assessed each Georgia region's obstetric provider workforce to identify service-deficient areas. *Methods* We identified 63 birthing facilities in the 82 Primary Care Service Areas (PCSAs) outside metropolit... περισσότερα »
The Relation of Neighborhood Income to the Age-Related Patterns of Preterm Birth Among White and African-American Women: The Effect of Cigarette Smoking
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Abstract *Objectives* We investigated the contributions of cigarette smoking to the age-related patterns of preterm (<37 weeks) birth (PTB) rates among African-American and White women within the context of lifelong neighborhood income. *Method*s Stratified and multilevel logistic regression analyses were performed on an Illinois transgenerational dataset of non-Hispanic White and African-American infants (1989–1991) and their mothers (1956–1976) with appended US census income information. *Results*: Among non-smoking African-American women (n = 20,107) with a lifelong residence i... περισσότερα »
Ethnic Differences in Gestational Weight Gain: A Population-Based Cohort Study in Norway
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
Abstract *Objectives* To explore ethnic differences in gestational weight gain (GWG). *Methods* This was a population-based cohort study conducted in primary care child health clinics in Groruddalen, Oslo, Norway. Participants were healthy pregnant women (n = 632) categorised to six ethnic groups (43 % were Western European women, the reference group). Body weight was measured at 15 and 28 weeks' gestation on average. Data on pre-pregnancy weight and total GWG until delivery were self-reported. The main method of analysis was linear regression adjusting for age, weeks' gestation, ... περισσότερα »
Prevalence of CTX-M enzyme and qnrA, qnrB, qnrC, qnrS, aac-(6)-Ib genes among ESBL (Extended spectrum beta lactamase)-positive isolates in patients undergoing transrectal needle prostate biopsy in Turkey.
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
2016-06-15T18-32-38Z *Source:* Disease and Molecular Medicine Elif Tükenmez Tigen, Zafer Tandoğdu, Gülşen Altınkanat, Arzu Doğru, Buket Erturk Sengel, Korten Volkan. Fecal carriage is one of the most important reasons for extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) causing infections. We aimed to demonstrate epidemiological features for subtype of ESBL-PE-encoding TEM, SHV and CTX-M as well as for qnrA, qnrB, qnrC, qnrS, aac-(6)-Ib genes through polymerase chain reaction (PCR) in patients undergoing transrectal needle prostate biopsy (TRNBP). Between Octo... περισσότερα »
How do medical students develop the selfawareness as social entities during the longitudinal communication experience with citizens?
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 34 δευτερόλεπτα
2016-06-15T17-07-20Z *Source:* Journal of Contemporary Medical Education Takuya Saiki, Keiko Abe, Chihiro Kawakami, Kazuhiko Fujisaki, Yasuyuki Suzuki. Objective: Diverse interactions with local citizens are known to broaden the health perspectives of medical students, stimulating their motivation to learn, and improving their communication skills. In recent years, the rapid decrease in birth rates and the transition toward a nuclear family structure have posed a challenge for medical students in Japan, given their lack of experience in communicating with citizens who are older than... περισσότερα »
Three-dimensional collagen matrix in head and neck cancer patient
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Expansion of the peri-implant attached gingiva with a three-dimensional collagen matrix in head and neck cancer patients—results from a prospective clinical and histological study: Abstract Objectives Attached peri-implant gingiva has proven to have an influence on the long-term stability of dental implants. In patients with head and neck cancer, a functional peri-implant gingiva is even […]
Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Microglial Signaling in Chronic Pain with a Special Focus on Caspase 6, p38 MAP Kinase, and Sex Dependence: Microglia are the resident immune cells in the spinal cord and brain. Mounting evidence suggests that activation of microglia plays an important role in the pathogenesis of chronic pain, including chronic orofacial pain. In particular, microglia contribute […]
Role of Oxidized Lipids and TRP Channels in Orofacial Pain and Inflammation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Role of Oxidized Lipids and TRP Channels in Orofacial Pain and Inflammation: Acute or chronic inflammation comprises a highly prevalent type of orofacial pain and is mediated by the generation of endogenous agonists that activate numerous receptors expressed on terminals of trigeminal (TG) nociceptive afferent neurons. One such studied receptor is transient receptor potential vanilloid […]
Pain and Disability in the Jaw and Neck Region following Whiplash Trauma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Pain and Disability in the Jaw and Neck Region following Whiplash Trauma: The relationship between whiplash trauma and chronic orofacial pain is unclear, especially with regard to the time elapsed from trauma to development of orofacial pain. The aim was to analyze prevalence of jaw pain and disability, as well as the relationship between pain […]
Reaction-response time parameters and gait patterns of patients with multiple sclerosis (MS)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
EFFECT OF DUAL-TASK-INDUCED UNCERTAINTY ON GAIT BIOMECHANICS IN PATIENTS WITH MULTIPLE SCLEROSIS WITH 2 TO 6.5 EDSS GRADE via Gait & Posture Publication date: Available online 15 June 2016Source:Gait & PostureAuthor(s): Carmen Gutiérrez Cruz, Juan Carlos Miangolarra, F. Javier RojasThe goal of this study was to assess the effect that uncertainty induced by dual task conditions […]
Cytomegalovirus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
the stealth virus.: Pract Midwife. 2016;19(5):28-9 Authors: Robinson S Abstract Cytomegalovirus (CMV) is an infection, part of the herpes family of viruses which, if contracted during pregnancy, cancause devastating effects on the newborn baby. This article is written by the trustee of a volunteer-based charity, mostly run by mothers of CMV children, who are striving […]
Assessment of gait abnormalities in cerebral palsy (CP)
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Reliability and Validity of Edinburgh Visual Gait Score as an Evaluation Tool for Children with Cerebral Palsy via Gait & Posture Publication date: Available online 15 June 2016Source:Gait & PostureAuthor(s): Maria del Pilar Duque Orozco, Oussama Abousamra, Church Chris, Lennon Nancy, John Henley, Kenneth J. Rogers, Julieanne P. Sees, Justin Connor, Freeman MillerAssessment of gait abnormalities […]
Intermittent postural control
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Differences in intermittent postural control between normal-weight and obese children via Gait & Posture Publication date: Available online 15 June 2016Source:Gait & PostureAuthor(s): Israel Villarrasa-Sapiña, Xavier García-Massó, Pilar Serra-Añó, Consolación Garcia-Lucerga, Luis-Millán Gonzalez, Empar LurbeAimThe main objective of this study was to determine differences in postural control between obese and non-obese children.MethodsThe study design was cross-sectional, […]
Tinnitus
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
Cure Tinnitus Permanently & Naturally: Can You Really Cure Tinnitus Permanently & Naturally? Many people are desperately trying to find ways to cure tinnitus permanently & naturally. However, there is no way to naturally and permanently cure tinnitus. Tinnitus is a complex medical problem, and it is not always possible to find the causes of […]
Squamous cell carcinoma (SCC) – Cancer – Melanoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 39 δευτερόλεπτα
21m Cancer by Sfakianakis G.Alexandros Cancer Predisposition Testing in Unselected Cancer Patients Sequencing for somatic alterations in patients’ tumors is being increasingly clinically implemented to detect mutations that may guide therapy. Germline analysis of a cohort of patients undergoing tumor sequencing with matched normal has revealed that a small but significant percentage of these […]
Antibody-Dependent Cell-Mediated Cytotoxicity to Hemagglutinin of Influenza A Viruses After Influenza Vaccination in Humans
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Background. Detection of neutralizing antibodies (nAbs) to influenza A virus hemagglutinin (HA) antigens by conventional serological assays is currently the main immune correlate of protection for influenza vaccines However, current prepandemic avian influenza vaccines are poorly immunogenic in inducing nAbs despite considerable protection conferred. Recent studies show that Ab-dependent cell-mediated cytotoxicity (ADCC) to HA antigens […]
Correlates of Immunity to Influenza as Determined by Challenge of Children with Live, Attenuated Influenza Vaccine
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Background. The efficacy of live, attenuated live attenuated influenza vaccine(LAIV) and inactivated influenza vaccine(IIV) is poorly explained by either single or composite immune responses to vaccination. Protective biomarkers were therefore studied in response to LAIV or IIV followed by LAIV challenge in children. Methods. Serum and mucosal responses to LAIV or IIV were analyzed using […]
Contribution of Genetic Background and Clinical Risk Factors to Low-Trauma Fractures in Human Immunodeficiency Virus (HIV)-Positive Persons: The Swiss HIV Cohort Study
sfakianakistherapeuticsστοTherapeutics Infections Emergencies MEDICINE BY ALEXANDROS G.SFAKIANAKIS,ANAPAFSEOS 5 AGIOS NIKOLAOS,CRETE 72100,GREECE,TEL :00302841026182 & 00306932607174Πριν από 43 δευτερόλεπτα
Background. The impact of human genetic background on low-trauma fracture (LTF) risk has not been evaluated in the context of human immunodeficiency virus (HIV) and clinical LTF risk factors. Methods. In the general population, 6 common single-nucleotide polymorphisms (SNPs) associate with LTF through genome-wide association study. Using genome-wide SNP arrays and imputation, we genotyped these […]
Ethno-Specific Risk Factors for Adverse Pregnancy Outcomes: Findings from the Born in Bradford Cohort Study
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract *Objectives* Preterm birth (PTB) and small for gestational age (SGA) are major causes of perinatal mortality and morbidity. Previous studies indicated a range of risk factors associated with these poor outcomes, including maternal psychosocial and economic wellbeing. This paper will explore a range of psycho-social and economic factors in an ethnically diverse population. *Methods* The UK's Born in Bradford cohort study recruited pregnant women attending a routine antenatal appointment at 26–28 weeks' gestation at the Bradford Royal Infirmary (2007–2010). This analysis in... περισσότερα »
Commentary on Obstetric Care in Rural Georgia
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract This is an invited commentary on five articles on obstetric care in rural Georgia. from Health via xlomafota13 on Inoreader http://ift.tt/1VZxexR via IFTTT
Obstetric Provider Trainees in Georgia: Characteristics and Attitudes About Practice in Obstetric Provider Shortage Areas
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 1 ώρα
Abstract *Objectives* In Georgia, 52 % of the primary care service areas outside metropolitan Atlanta have a deficit of obstetric providers. This study was designed to identify factors associated with the likelihood of Georgia's obstetric trainees (obstetrics and gynecology (OB/GYN) residents and certified nurse midwifery (CNM) students) to practice in areas of Georgia that lack obstetric providers and services, i.e. rural Georgia. *Methods* Pilot-tested electronic and paper surveys were distributed to all of Georgia's OB/GYN residents (N = 95) and CNM students (N = 28). Mixed-met... περισσότερα »
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