Ceramic variation and negotiated communities in the Late Valdivia phase of coastal Ecuador
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Publication date: September 2016
Source:Journal of Anthropological Archaeology, Volume 43
Author(s): Sarah M. Rowe
Previous research of prehispanic coastal Ecuador has argued for the development of social hierarchies during the Late Valdivia period (2400–1800 BCE), based on changing regional settlement patterns, increased long-distance exchange, and increasing intra-site differentiation. Recent investigations at Valdivia sites have highlighted the diversity of settlement patterns and social forms during this period. The present research utilizes a negotiated community framework to investigate practices of community formation and maintenance. Through a comparative analysis of ceramic assemblages from four Late Valdivia sites I highlight differences in ceramic use and assemblage composition that indicate diverging ways of fomenting community through participation in communal eating. These differences point to the negotiated nature of communities, highlighting differing strategies for community maintenance at different sites, and emphasizing the contingent nature of increasing social complexity within Valdivia society.
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Source:Journal of Anthropological Archaeology, Volume 43
Author(s): Sarah M. Rowe
Previous research of prehispanic coastal Ecuador has argued for the development of social hierarchies during the Late Valdivia period (2400–1800 BCE), based on changing regional settlement patterns, increased long-distance exchange, and increasing intra-site differentiation. Recent investigations at Valdivia sites have highlighted the diversity of settlement patterns and social forms during this period. The present research utilizes a negotiated community framework to investigate practices of community formation and maintenance. Through a comparative analysis of ceramic assemblages from four Late Valdivia sites I highlight differences in ceramic use and assemblage composition that indicate diverging ways of fomenting community through participation in communal eating. These differences point to the negotiated nature of communities, highlighting differing strategies for community maintenance at different sites, and emphasizing the contingent nature of increasing social complexity within Valdivia society.
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Electronic nicotine delivery system landscape in licensed tobacco retailers: results of a county-level survey in Oklahoma
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Objectives
Electronic nicotine delivery systems (ENDS) have recently emerged as a component of the tobacco retail environment. The aims of this study were to describe the availability, types of ENDS and placement of ENDS relative to traditional tobacco products at franchised licensed tobacco retailers and non-franchised licensed tobacco retailers.
Design Observational study.
Setting Franchised and non-franchised tobacco retailers in Cleveland County, Oklahoma, USA.
Primary and secondary outcome measures The number of stores selling ENDS, the variability in brands of ENDS sold, the location of the ENDS within the retailers, the quantity of ENDS sold compared with traditional tobacco products, and the presence of outdoor signage.
Results Data from 57 randomly sampled tobacco retailers were used to describe the presence of ENDS at independent non-franchised and franchised tobacco retailers. The overwhelming majority (90%) of licensed tobacco retailers sold ENDS, and differences were observed between franchised and non-franchised stores. 45 of the 51 retailers (88%) selling ENDS had them placed at the point of sale. 2 of the 21 franchised retailers (9.5%) had ENDS placed at ≤31/2 feet above floor level compared to none of the 30 non-franchised retailers (0%).
Conclusions This small study is the first to characterise ENDS within the tobacco retail environment in a county in Oklahoma, USA. The results from this study demonstrate the complexity of the tobacco retail landscape and generate questions for future studies regarding the incorporation and placement of ENDS in tobacco retail environments.
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Electronic nicotine delivery systems (ENDS) have recently emerged as a component of the tobacco retail environment. The aims of this study were to describe the availability, types of ENDS and placement of ENDS relative to traditional tobacco products at franchised licensed tobacco retailers and non-franchised licensed tobacco retailers.
Design Observational study.
Setting Franchised and non-franchised tobacco retailers in Cleveland County, Oklahoma, USA.
Primary and secondary outcome measures The number of stores selling ENDS, the variability in brands of ENDS sold, the location of the ENDS within the retailers, the quantity of ENDS sold compared with traditional tobacco products, and the presence of outdoor signage.
Results Data from 57 randomly sampled tobacco retailers were used to describe the presence of ENDS at independent non-franchised and franchised tobacco retailers. The overwhelming majority (90%) of licensed tobacco retailers sold ENDS, and differences were observed between franchised and non-franchised stores. 45 of the 51 retailers (88%) selling ENDS had them placed at the point of sale. 2 of the 21 franchised retailers (9.5%) had ENDS placed at ≤31/2 feet above floor level compared to none of the 30 non-franchised retailers (0%).
Conclusions This small study is the first to characterise ENDS within the tobacco retail environment in a county in Oklahoma, USA. The results from this study demonstrate the complexity of the tobacco retail landscape and generate questions for future studies regarding the incorporation and placement of ENDS in tobacco retail environments.
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Validation of the Kinyarwanda-version Short-Form Leeds Dyspepsia Questionnaire and Short-Form Nepean Dyspepsia Index to assess dyspepsia prevalence and quality-of-life impact in Rwanda
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Objectives
We aimed to develop and validate Kinyarwanda versions of Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) and Short-Form Nepean Dyspepsia Index (SF-NDI) to measure the frequency and severity of dyspepsia and associated quality-of-life impact in Rwanda.
Setting A single, tertiary care centre in Rwanda.
Participants 200 consecutive Kinyarwanda-speaking patients referred to endoscopy (100 patients) or medical outpatients (100 patients).
Interventions Kinyarwanda versions of the SF-LDQ and SF-NDI were developed from English versions by translation, with back translation, crosschecking and pilot testing. Study participants completed these questionnaires at enrolment (time 1), and then completed the surveys again with blinded phone interviewers 3 days later (time 2). 20 randomly selected participants, diagnosed with a peptic ulcer on index endoscopy, completed a third survey by phone at day 30 (time 3), after therapy.
Primary outcome measures Internal consistency at time 1 (by Cronbach's α) and test–retest reliability between time 1 and time 2 (Spearman's correlation coefficient) for translated SF-LDQ and SF-NDI; validity versus clinical diagnosis (by receiver operating characteristic (ROC) curve) and responsiveness to treatment for SF-LDQ (by change in mean score). All outcomes were measured as per protocol.
Results Cronbach's α of the translated SF-LDQ was 0.93, showing high internal consistency. Spearman's correlation coefficient comparing time 1 and time 2 was 0.978 (p<0.001), demonstrating high reliability. Cronbach's α for the translated SF-NDI was 0.92. A cut-off score of 16 on the SF-LDQ showed a sensitivity of 97% and a specificity of 71% for the diagnosis of dyspepsia, correctly classifying 89% of patients. In the responsiveness analysis, the mean SF-LDQ score was reduced from 20.1 prior to treatment to 13.9 after 30 days of treatment (p=0.003).
Conclusions The Kinyarwanda versions of the SF-LDQ and SF-NDI were valid, reliable and responsive to treatment.
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We aimed to develop and validate Kinyarwanda versions of Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) and Short-Form Nepean Dyspepsia Index (SF-NDI) to measure the frequency and severity of dyspepsia and associated quality-of-life impact in Rwanda.
Setting A single, tertiary care centre in Rwanda.
Participants 200 consecutive Kinyarwanda-speaking patients referred to endoscopy (100 patients) or medical outpatients (100 patients).
Interventions Kinyarwanda versions of the SF-LDQ and SF-NDI were developed from English versions by translation, with back translation, crosschecking and pilot testing. Study participants completed these questionnaires at enrolment (time 1), and then completed the surveys again with blinded phone interviewers 3 days later (time 2). 20 randomly selected participants, diagnosed with a peptic ulcer on index endoscopy, completed a third survey by phone at day 30 (time 3), after therapy.
Primary outcome measures Internal consistency at time 1 (by Cronbach's α) and test–retest reliability between time 1 and time 2 (Spearman's correlation coefficient) for translated SF-LDQ and SF-NDI; validity versus clinical diagnosis (by receiver operating characteristic (ROC) curve) and responsiveness to treatment for SF-LDQ (by change in mean score). All outcomes were measured as per protocol.
Results Cronbach's α of the translated SF-LDQ was 0.93, showing high internal consistency. Spearman's correlation coefficient comparing time 1 and time 2 was 0.978 (p<0.001), demonstrating high reliability. Cronbach's α for the translated SF-NDI was 0.92. A cut-off score of 16 on the SF-LDQ showed a sensitivity of 97% and a specificity of 71% for the diagnosis of dyspepsia, correctly classifying 89% of patients. In the responsiveness analysis, the mean SF-LDQ score was reduced from 20.1 prior to treatment to 13.9 after 30 days of treatment (p=0.003).
Conclusions The Kinyarwanda versions of the SF-LDQ and SF-NDI were valid, reliable and responsive to treatment.
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Default options in advance directives: study protocol for a randomised clinical trial
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Introduction
Although most seriously ill Americans wish to avoid burdensome and aggressive care at the end of life, such care is often provided unless patients or family members specifically request otherwise. Advance directives (ADs) were created to provide opportunities to set limits on aggressive care near life's end. This study tests the hypothesis that redesigning ADs such that comfort-oriented care is provided as the default, rather than requiring patients to actively choose it, will promote better patient-centred outcomes.
Methods and analysis This multicentre trial randomises seriously ill adults to receive 1 of 3 different ADs: (1) a traditional AD that requires patients to actively choose their goals of care or preferences for specific interventions (eg, feeding tube insertion) or otherwise have their care guided by their surrogates and the prevailing societal default toward aggressive care; (2) an AD that defaults to life-extending care and receipt of life-sustaining interventions, enabling patients to opt out from such care; or (3) an AD that defaults to comfort care, enabling patients to opt into life-extending care. We seek to enrol 270 patients who return complete, legally valid ADs so as to generate sufficient power to detect differences in the primary outcome of hospital-free days (days alive and not in an acute care facility). Secondary outcomes include hospital and intensive care unit admissions, costs of care, hospice usage, decision conflict and satisfaction, quality of life, concordance of preferences with care received and bereavement outcomes for surrogates of patients who die.
Ethics and dissemination This study has been approved by the Institutional Review Boards at all trial centres, and is guided by a data safety and monitoring board and an ethics advisory board. Study results will be disseminated using methods that describe the results in ways that key stakeholders can best understand and implement.
Trial registration number NCT02017548; Pre-results.
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Although most seriously ill Americans wish to avoid burdensome and aggressive care at the end of life, such care is often provided unless patients or family members specifically request otherwise. Advance directives (ADs) were created to provide opportunities to set limits on aggressive care near life's end. This study tests the hypothesis that redesigning ADs such that comfort-oriented care is provided as the default, rather than requiring patients to actively choose it, will promote better patient-centred outcomes.
Methods and analysis This multicentre trial randomises seriously ill adults to receive 1 of 3 different ADs: (1) a traditional AD that requires patients to actively choose their goals of care or preferences for specific interventions (eg, feeding tube insertion) or otherwise have their care guided by their surrogates and the prevailing societal default toward aggressive care; (2) an AD that defaults to life-extending care and receipt of life-sustaining interventions, enabling patients to opt out from such care; or (3) an AD that defaults to comfort care, enabling patients to opt into life-extending care. We seek to enrol 270 patients who return complete, legally valid ADs so as to generate sufficient power to detect differences in the primary outcome of hospital-free days (days alive and not in an acute care facility). Secondary outcomes include hospital and intensive care unit admissions, costs of care, hospice usage, decision conflict and satisfaction, quality of life, concordance of preferences with care received and bereavement outcomes for surrogates of patients who die.
Ethics and dissemination This study has been approved by the Institutional Review Boards at all trial centres, and is guided by a data safety and monitoring board and an ethics advisory board. Study results will be disseminated using methods that describe the results in ways that key stakeholders can best understand and implement.
Trial registration number NCT02017548; Pre-results.
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Identifying improvements to complex pathways: evidence synthesis and stakeholder engagement in infant congenital heart disease
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Objectives
Many infants die in the year following discharge from hospital after surgical or catheter intervention for congenital heart disease (3–5% of discharged infants). There is considerable variability in the provision of care and support in this period, and some families experience barriers to care. We aimed to identify ways to improve discharge and postdischarge care for this patient group.
Design A systematic evidence synthesis aligned with a process of eliciting the perspectives of families and professionals from community, primary, secondary and tertiary care.
Setting UK.
Results A set of evidence-informed recommendations for improving the discharge and postdischarge care of infants following intervention for congenital heart disease was produced. These address known challenges with current care processes and, recognising current resource constraints, are targeted at patient groups based on the number of patients affected and the level and nature of their risk of adverse 1-year outcome. The recommendations include: structured discharge documentation, discharging certain high-risk patients via their local hospital, enhanced surveillance for patients with certain (high-risk) cardiac diagnoses and an early warning tool for parents and community health professionals.
Conclusions Our recommendations set out a comprehensive, system-wide approach for improving discharge and postdischarge services. This approach could be used to address challenges in delivering care for other patient populations that can fall through gaps between sectors and organisations.
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Many infants die in the year following discharge from hospital after surgical or catheter intervention for congenital heart disease (3–5% of discharged infants). There is considerable variability in the provision of care and support in this period, and some families experience barriers to care. We aimed to identify ways to improve discharge and postdischarge care for this patient group.
Design A systematic evidence synthesis aligned with a process of eliciting the perspectives of families and professionals from community, primary, secondary and tertiary care.
Setting UK.
Results A set of evidence-informed recommendations for improving the discharge and postdischarge care of infants following intervention for congenital heart disease was produced. These address known challenges with current care processes and, recognising current resource constraints, are targeted at patient groups based on the number of patients affected and the level and nature of their risk of adverse 1-year outcome. The recommendations include: structured discharge documentation, discharging certain high-risk patients via their local hospital, enhanced surveillance for patients with certain (high-risk) cardiac diagnoses and an early warning tool for parents and community health professionals.
Conclusions Our recommendations set out a comprehensive, system-wide approach for improving discharge and postdischarge services. This approach could be used to address challenges in delivering care for other patient populations that can fall through gaps between sectors and organisations.
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When procedures meet practice in community pharmacies: qualitative insights from pharmacists and pharmacy support staff
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Objectives
Our aim was to explore how members of community pharmacy staff perceive and experience the role of procedures within the workplace in community pharmacies.
Setting Community pharmacies in England and Wales.
Participants 24 community pharmacy staff including pharmacists and pharmacy support staff were interviewed regarding their view of procedures in community pharmacy. Transcripts were analysed using thematic analysis.
Results 3 main themes were identified. According to the 'dissemination and creation of standard operating procedures' theme, community pharmacy staff were required to follow a large amount of procedures as part of their work. At times, complying with all procedures was not possible. According to the 'complying with procedures' theme, there are several factors that influenced compliance with procedures, including work demands, the high workload and the social norm within the pharmacy. Lack of staff, pressure to hit targets and poor communication also affected how able staff felt to follow procedures. The third theme 'procedural compliance versus using professional judgement' highlighted tensions between the standardisation of practice and the professional autonomy of pharmacists. Pharmacists feared being unsupported by their employer for working outside of procedures, even when acting for patient benefit. Some support staff believed that strictly following procedures would keep patients and themselves safe. Dispensers described following the guidance of the pharmacist which sometimes meant working outside of procedures, but occasionally felt unable to voice concerns about not working to rule.
Conclusions Organisational resilience in community pharmacy was apparent and findings from this study should help to inform policymakers and practitioners regarding factors likely to influence the implementation of procedures in community pharmacy settings. Future research should focus on exploring community pharmacy employees' intentions and attitudes towards rule-breaking behaviour and the impact this may have on patient safety.
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Our aim was to explore how members of community pharmacy staff perceive and experience the role of procedures within the workplace in community pharmacies.
Setting Community pharmacies in England and Wales.
Participants 24 community pharmacy staff including pharmacists and pharmacy support staff were interviewed regarding their view of procedures in community pharmacy. Transcripts were analysed using thematic analysis.
Results 3 main themes were identified. According to the 'dissemination and creation of standard operating procedures' theme, community pharmacy staff were required to follow a large amount of procedures as part of their work. At times, complying with all procedures was not possible. According to the 'complying with procedures' theme, there are several factors that influenced compliance with procedures, including work demands, the high workload and the social norm within the pharmacy. Lack of staff, pressure to hit targets and poor communication also affected how able staff felt to follow procedures. The third theme 'procedural compliance versus using professional judgement' highlighted tensions between the standardisation of practice and the professional autonomy of pharmacists. Pharmacists feared being unsupported by their employer for working outside of procedures, even when acting for patient benefit. Some support staff believed that strictly following procedures would keep patients and themselves safe. Dispensers described following the guidance of the pharmacist which sometimes meant working outside of procedures, but occasionally felt unable to voice concerns about not working to rule.
Conclusions Organisational resilience in community pharmacy was apparent and findings from this study should help to inform policymakers and practitioners regarding factors likely to influence the implementation of procedures in community pharmacy settings. Future research should focus on exploring community pharmacy employees' intentions and attitudes towards rule-breaking behaviour and the impact this may have on patient safety.
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Clinical outcomes at 12 months and risk of inflammatory bowel disease in patients with an intermediate raised fecal calprotectin: a 'real-world view
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Objectives
A recent systematic review confirmed the usefulness of fecal calprotectin (FC) in distinguishing organic (inflammatory bowel disease (IBD)) from non-organic gastrointestinal disease (irritable bowel syndrome (IBS)). FC levels <50 μg/g have a negative predictive value >92% to exclude organic gastrointestinal (GI) disease. Levels >250 μg/g correlate with endoscopic IBD disease activity; sensitivity 90%. We aimed to determine clinical outcomes in intermediate raised FC results (50–250 μg/g).
Setting Primary care general practices in Coventry and Warwickshire, and 3 secondary care hospitals.
Participants 443 FC results in adults (>16 years old) were reviewed from July 2012 to October 2013. Clinical data was collected from hospital databases and general practitioners. Long-term clinical data was available in 41 patients (out of 48).
Primary and secondary outcome measures The number of new diagnoses of IBD, IBS and other diagnoses for the intermediate group. The number referred and discharged from secondary care.
Results A new IBD diagnosis was made in 19% (n=8) of intermediate results (1% of normal and 38% of raised results). 5% (n=2) of intermediate results had known IBD in remission. A new IBS diagnosis was made in 27% (n=11) of intermediate results, while 34% (n=14) remained undiagnosed, although 8 of these were not referred to secondary care.
Conclusions FC testing remains useful in aiding diagnosis of organic GI conditions. However, unlike negative and strongly positive FC results, intermediate FC results lead to a mixture of diagnoses. The OR of a new diagnosis of IBD for an intermediate result compared to normal FC result was 26.6, while an intermediate FC result gave an OR of 0.54 for a new IBS diagnosis compared to normal FC. For intermediate FC results, 1 in 3 patients remained in secondary care after 12 months with an OR of 3.6 compared to a normal FC result.
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A recent systematic review confirmed the usefulness of fecal calprotectin (FC) in distinguishing organic (inflammatory bowel disease (IBD)) from non-organic gastrointestinal disease (irritable bowel syndrome (IBS)). FC levels <50 μg/g have a negative predictive value >92% to exclude organic gastrointestinal (GI) disease. Levels >250 μg/g correlate with endoscopic IBD disease activity; sensitivity 90%. We aimed to determine clinical outcomes in intermediate raised FC results (50–250 μg/g).
Setting Primary care general practices in Coventry and Warwickshire, and 3 secondary care hospitals.
Participants 443 FC results in adults (>16 years old) were reviewed from July 2012 to October 2013. Clinical data was collected from hospital databases and general practitioners. Long-term clinical data was available in 41 patients (out of 48).
Primary and secondary outcome measures The number of new diagnoses of IBD, IBS and other diagnoses for the intermediate group. The number referred and discharged from secondary care.
Results A new IBD diagnosis was made in 19% (n=8) of intermediate results (1% of normal and 38% of raised results). 5% (n=2) of intermediate results had known IBD in remission. A new IBS diagnosis was made in 27% (n=11) of intermediate results, while 34% (n=14) remained undiagnosed, although 8 of these were not referred to secondary care.
Conclusions FC testing remains useful in aiding diagnosis of organic GI conditions. However, unlike negative and strongly positive FC results, intermediate FC results lead to a mixture of diagnoses. The OR of a new diagnosis of IBD for an intermediate result compared to normal FC result was 26.6, while an intermediate FC result gave an OR of 0.54 for a new IBS diagnosis compared to normal FC. For intermediate FC results, 1 in 3 patients remained in secondary care after 12 months with an OR of 3.6 compared to a normal FC result.
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Comparing cognitive-behavioural psychotherapy and psychoeducation for non-specific symptoms associated with indoor air: a randomised control trial protocol
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Introduction
Indoor air-related conditions share similarities with other conditions that are characterised by medically unexplained symptoms (MUS)-a combination of non-specific symptoms that cannot be fully explained by structural bodily pathology. In cases of indoor air-related conditions, these symptoms are not fully explained by either medical conditions or the immunological–toxicological effects of environmental factors. The condition may be disabling, including a non-adaptive health behaviour. In this multifaceted phenomenon, psychosocial factors influence the experienced symptoms. Currently, there is no evidence of clinical management of symptoms, which are associated with the indoor environment and cannot be resolved by removing the triggering environmental factors. The aim of this study is to compare the effect of treatment-as-usual (TAU) and two psychosocial interventions on the quality of life, and the work ability of employees with non-specific indoor air-related symptomatology.
Methods and analyses The aim of this ongoing randomised controlled trial is to recruit 60 participants, in collaboration with 5 occupational health service units. The main inclusion criterion is the presence of indoor air-related recurrent symptoms in ≥2 organ systems, which have no pathophysiological explanation. After baseline clinical investigations, participants are randomised into interventions, which all include TAU: cognitive-behavioural psychotherapy, psychoeducation and TAU (control condition). Health-related quality of life, measured using the 15D-scale, is the primary outcome. Secondary outcomes include somatic and psychiatric symptoms, occupational factors, and related underlying mechanisms (ie, cognitive functioning). Questionnaires are completed at baseline, at 3, 6 and 12-month follow-ups. Data collection will continue until 2017. The study will provide new information on the individual factors related to indoor air-associated symptoms, and on ways in which to support work ability.
Ethics and dissemination The Coordinating Ethics Committee of the Hospital District of Helsinki and Uusimaa, Finland, has granted approval for the study. The results will be published in peer-reviewed journals.
Trial registration number NCT02069002; Pre-results.
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Indoor air-related conditions share similarities with other conditions that are characterised by medically unexplained symptoms (MUS)-a combination of non-specific symptoms that cannot be fully explained by structural bodily pathology. In cases of indoor air-related conditions, these symptoms are not fully explained by either medical conditions or the immunological–toxicological effects of environmental factors. The condition may be disabling, including a non-adaptive health behaviour. In this multifaceted phenomenon, psychosocial factors influence the experienced symptoms. Currently, there is no evidence of clinical management of symptoms, which are associated with the indoor environment and cannot be resolved by removing the triggering environmental factors. The aim of this study is to compare the effect of treatment-as-usual (TAU) and two psychosocial interventions on the quality of life, and the work ability of employees with non-specific indoor air-related symptomatology.
Methods and analyses The aim of this ongoing randomised controlled trial is to recruit 60 participants, in collaboration with 5 occupational health service units. The main inclusion criterion is the presence of indoor air-related recurrent symptoms in ≥2 organ systems, which have no pathophysiological explanation. After baseline clinical investigations, participants are randomised into interventions, which all include TAU: cognitive-behavioural psychotherapy, psychoeducation and TAU (control condition). Health-related quality of life, measured using the 15D-scale, is the primary outcome. Secondary outcomes include somatic and psychiatric symptoms, occupational factors, and related underlying mechanisms (ie, cognitive functioning). Questionnaires are completed at baseline, at 3, 6 and 12-month follow-ups. Data collection will continue until 2017. The study will provide new information on the individual factors related to indoor air-associated symptoms, and on ways in which to support work ability.
Ethics and dissemination The Coordinating Ethics Committee of the Hospital District of Helsinki and Uusimaa, Finland, has granted approval for the study. The results will be published in peer-reviewed journals.
Trial registration number NCT02069002; Pre-results.
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Longitudinal trends in use and costs of targeted therapies for common cancers in Taiwan: a retrospective observational study
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Objectives
Some targeted therapies have improved survival and overall quality of cancer care generally, but these increasingly expensive medicines have led to increases in pharmaceutical expenditure. This study examined trends in use and expenditures of antineoplastic agents in Taiwan, and estimated market shares by prescription volume and costs of targeted therapies over time. We also determined which cancer types accounted for the highest use of targeted therapies.
Design This is a retrospective observational study focusing on the utilisation of targeted therapies for treatment of cancer.
Setting The monthly claims data for antineoplastic agents were retrieved from Taiwan's National Health Insurance Research Database (2009–2012).
Main outcome measures We calculated market shares by prescription volume and costs for each class of antineoplastic agent by cancer type. Using a time series design with Autoregressive Integrated Moving Average (ARIMA) models, we estimated trends in use and costs of targeted therapies.
Results Among all antineoplastic agents, use of targeted therapies grew from 6.24% in 2009 to 12.29% in 2012, but their costs rose from 26.16% to 41.57% in that time. Monoclonal antibodies and protein kinase inhibitors contributed the most (respectively, 23.84% and 16.12% of costs for antineoplastic agents in 2012). During 2009–2012, lung (44.64% of use; 28.26% of costs), female breast (16.49% of use; 27.18% of costs) and colorectal (12.11% of use; 13.16% of costs) cancers accounted for the highest use of targeted therapies.
Conclusions In Taiwan, targeted therapies are increasingly used for different cancers, representing a substantial economic burden. It is important to establish mechanisms to monitor their use and outcomes.
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Some targeted therapies have improved survival and overall quality of cancer care generally, but these increasingly expensive medicines have led to increases in pharmaceutical expenditure. This study examined trends in use and expenditures of antineoplastic agents in Taiwan, and estimated market shares by prescription volume and costs of targeted therapies over time. We also determined which cancer types accounted for the highest use of targeted therapies.
Design This is a retrospective observational study focusing on the utilisation of targeted therapies for treatment of cancer.
Setting The monthly claims data for antineoplastic agents were retrieved from Taiwan's National Health Insurance Research Database (2009–2012).
Main outcome measures We calculated market shares by prescription volume and costs for each class of antineoplastic agent by cancer type. Using a time series design with Autoregressive Integrated Moving Average (ARIMA) models, we estimated trends in use and costs of targeted therapies.
Results Among all antineoplastic agents, use of targeted therapies grew from 6.24% in 2009 to 12.29% in 2012, but their costs rose from 26.16% to 41.57% in that time. Monoclonal antibodies and protein kinase inhibitors contributed the most (respectively, 23.84% and 16.12% of costs for antineoplastic agents in 2012). During 2009–2012, lung (44.64% of use; 28.26% of costs), female breast (16.49% of use; 27.18% of costs) and colorectal (12.11% of use; 13.16% of costs) cancers accounted for the highest use of targeted therapies.
Conclusions In Taiwan, targeted therapies are increasingly used for different cancers, representing a substantial economic burden. It is important to establish mechanisms to monitor their use and outcomes.
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Effect of affordable technology on physical activity levels and mobility outcomes in rehabilitation: a protocol for the Activity and MObility UsiNg Technology (AMOUNT) rehabilitation trial
Today, 7 Ιουνίου 2016,
7 hours ago | Αλέξανδρος Σφακιανάκης
Introduction
People with mobility limitations can benefit from rehabilitation programmes that provide a high dose of exercise. However, since providing a high dose of exercise is logistically challenging and resource-intensive, people in rehabilitation spend most of the day inactive. This trial aims to evaluate the effect of the addition of affordable technology to usual care on physical activity and mobility in people with mobility limitations admitted to inpatient aged and neurological rehabilitation units compared to usual care alone.
Methods and analysis A pragmatic, assessor blinded, parallel-group randomised trial recruiting 300 consenting rehabilitation patients with reduced mobility will be conducted. Participants will be individually randomised to intervention or control groups. The intervention group will receive technology-based exercise to target mobility and physical activity problems for 6 months. The technology will include the use of video and computer games/exercises and tablet applications as well as activity monitors. The control group will not receive any additional intervention and both groups will receive usual inpatient and outpatient rehabilitation care over the 6-month study period. The coprimary outcomes will be objectively assessed physical activity (proportion of the day spent upright) and mobility (Short Physical Performance Battery) at 6 months after randomisation. Secondary outcomes will include: self-reported and objectively assessed physical activity, mobility, cognition, activity performance and participation, utility-based quality of life, balance confidence, technology self-efficacy, falls and service utilisation. Linear models will assess the effect of group allocation for each continuously scored outcome measure with baseline scores entered as a covariate. Fall rates between groups will be compared using negative binomial regression. Primary analyses will be preplanned, conducted while masked to group allocation and use an intention-to-treat approach.
Ethics and dissemination The protocol has been approved by the relevant Human Research Ethics Committees and the results will be disseminated widely through peer-reviewed publication and conference presentations.
Trial registration number ACTRN12614000936628. Pre-results.
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People with mobility limitations can benefit from rehabilitation programmes that provide a high dose of exercise. However, since providing a high dose of exercise is logistically challenging and resource-intensive, people in rehabilitation spend most of the day inactive. This trial aims to evaluate the effect of the addition of affordable technology to usual care on physical activity and mobility in people with mobility limitations admitted to inpatient aged and neurological rehabilitation units compared to usual care alone.
Methods and analysis A pragmatic, assessor blinded, parallel-group randomised trial recruiting 300 consenting rehabilitation patients with reduced mobility will be conducted. Participants will be individually randomised to intervention or control groups. The intervention group will receive technology-based exercise to target mobility and physical activity problems for 6 months. The technology will include the use of video and computer games/exercises and tablet applications as well as activity monitors. The control group will not receive any additional intervention and both groups will receive usual inpatient and outpatient rehabilitation care over the 6-month study period. The coprimary outcomes will be objectively assessed physical activity (proportion of the day spent upright) and mobility (Short Physical Performance Battery) at 6 months after randomisation. Secondary outcomes will include: self-reported and objectively assessed physical activity, mobility, cognition, activity performance and participation, utility-based quality of life, balance confidence, technology self-efficacy, falls and service utilisation. Linear models will assess the effect of group allocation for each continuously scored outcome measure with baseline scores entered as a covariate. Fall rates between groups will be compared using negative binomial regression. Primary analyses will be preplanned, conducted while masked to group allocation and use an intention-to-treat approach.
Ethics and dissemination The protocol has been approved by the relevant Human Research Ethics Committees and the results will be disseminated widely through peer-reviewed publication and conference presentations.
Trial registration number ACTRN12614000936628. Pre-results.
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Modified PEEK Resin Bonded Fixed Dental Prosthesis for a Young Cleft Lip and Palate Patient
Today, 7 Ιουνίου 2016,
7 hours ago | Alexandros G. Sfakianakis
Abstract
Objective
This clinical report presents the use of a modified poly ether–ether ketone
material as an alternative material for the fabrication of resin-bonded fixed
dental prosthesis (RBFDP) framework. This new material can be used for patients
allergic to metals, maintaining the same high esthetic demand of ceramics,
presenting light weightness and a flexibility similar to bone as a distinct
advantage over ceramic materials.
Conclusions
The use of a BioHPP RBFDP framework could be considered as an alternative
restoration for the replacement of missing lateral incisors in young patients
with cleft palate defects.
Clinical Significance
This modified PEEK material known as BioHPP, is a biocompatible, non
allergic, rigid material with good mechanical properties, wear resistance,
chemical stability, high polishing and low absorption properties. BioHPP
frameworks can be manufactured either via CAD/CAM or via the conventional lost
wax technique. The low modulus of elasticity, combined with the use of indirect
composite resin as a veneering material, provide a distinct advantage over
ceramics or metal ceramics on dampening the occlusal forces, reducing the risk
of debonding. (J Esthet Restor Dent, 2016)
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Digital Dermoscopy Photographs Outperform Handheld Dermoscopy in Melanoma Diagnosis
Today, 7 Ιουνίου 2016,
7 hours ago
Background:
Pigmented lesion clinics (PLCs) that use technology such as digital
dermoscopy and total-body photography are thought to confer a clinical advantage
for patients at high risk of developing melanoma over general dermatology
clinics (GDCs) with regular dermoscopy.
Objective: To examine the difference between depths of melanomas diagnosed in a PLC and a GDC.
Methods: Medical records from 257 patients at the PLC at The Ottawa Hospital and 441 patients from a GDC were reviewed.
Results: Invasive melanoma was less frequent than in situ melanoma at the PLC (7.14% vs 38.27%; P = .02). The average Breslow depth for melanomas at the PLC was also smaller compared with the GDC (0.0371 vs 0.3450 mm; P = .02).
Conclusions: The use of digital dermoscopy and total-body photography together in a PLC appears to be an effective way to monitor patients at high risk of melanoma.
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Objective: To examine the difference between depths of melanomas diagnosed in a PLC and a GDC.
Methods: Medical records from 257 patients at the PLC at The Ottawa Hospital and 441 patients from a GDC were reviewed.
Results: Invasive melanoma was less frequent than in situ melanoma at the PLC (7.14% vs 38.27%; P = .02). The average Breslow depth for melanomas at the PLC was also smaller compared with the GDC (0.0371 vs 0.3450 mm; P = .02).
Conclusions: The use of digital dermoscopy and total-body photography together in a PLC appears to be an effective way to monitor patients at high risk of melanoma.
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Digital Dermoscopy Photographs Outperform Handheld Dermoscopy in Melanoma Diagnosis
Today, 7 Ιουνίου 2016,
7 hours ago
Background:
Pigmented lesion clinics (PLCs) that use technology such as digital
dermoscopy and total-body photography are thought to confer a clinical advantage
for patients at high risk of developing melanoma over general dermatology
clinics (GDCs) with regular dermoscopy.
Objective: To examine the difference between depths of melanomas diagnosed in a PLC and a GDC.
Methods: Medical records from 257 patients at the PLC at The Ottawa Hospital and 441 patients from a GDC were reviewed.
Results: Invasive melanoma was less frequent than in situ melanoma at the PLC (7.14% vs 38.27%; P = .02). The average Breslow depth for melanomas at the PLC was also smaller compared with the GDC (0.0371 vs 0.3450 mm; P = .02).
Conclusions: The use of digital dermoscopy and total-body photography together in a PLC appears to be an effective way to monitor patients at high risk of melanoma.
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Objective: To examine the difference between depths of melanomas diagnosed in a PLC and a GDC.
Methods: Medical records from 257 patients at the PLC at The Ottawa Hospital and 441 patients from a GDC were reviewed.
Results: Invasive melanoma was less frequent than in situ melanoma at the PLC (7.14% vs 38.27%; P = .02). The average Breslow depth for melanomas at the PLC was also smaller compared with the GDC (0.0371 vs 0.3450 mm; P = .02).
Conclusions: The use of digital dermoscopy and total-body photography together in a PLC appears to be an effective way to monitor patients at high risk of melanoma.
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A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine
Today, 7 Ιουνίου 2016,
7 hours ago
Aim
The aim of this trial was to evaluate the efficacy and tolerability of
ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist
(CGRP-RA), for the acute treatment of migraine.
Methods This double-blind, placebo-controlled study randomized 834 participants to treat one migraine attack with ubrogepant 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, or placebo in a 1:1 ratio. The co-primary endpoints were pain freedom and headache response at two hours. The first primary hypothesis tested the dose-response trend for two-hour pain freedom using a logistic regression model. Subsequent hypotheses tested the effects of each dose on the co-primary endpoints, using a closed sequential testing procedure to control for multiplicity.
Results A total of 527 participants received ubrogepant and 113 received placebo. A positive response trend in the proportion of participants achieving two-hour pain freedom was demonstrated (p < 0.001). Ubrogepant 100 mg was significantly superior to placebo for two-hour pain freedom (25.5% vs 8.9%) but not for two-hour headache response. Per the prespecified multiplicity strategy, this nonsignificant result precluded further formal hypothesis testing, although the 50 mg and 25 mg doses demonstrated nominal significance over placebo for two-hour pain freedom (unadjusted p < 0.05). Overall, adverse events were similar between ubrogepant and placebo.
Conclusion This trial supports ubrogepant’s efficacy and provides further evidence that CGRP-RAs are viable options for the acute treatment of migraine.
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Methods This double-blind, placebo-controlled study randomized 834 participants to treat one migraine attack with ubrogepant 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, or placebo in a 1:1 ratio. The co-primary endpoints were pain freedom and headache response at two hours. The first primary hypothesis tested the dose-response trend for two-hour pain freedom using a logistic regression model. Subsequent hypotheses tested the effects of each dose on the co-primary endpoints, using a closed sequential testing procedure to control for multiplicity.
Results A total of 527 participants received ubrogepant and 113 received placebo. A positive response trend in the proportion of participants achieving two-hour pain freedom was demonstrated (p < 0.001). Ubrogepant 100 mg was significantly superior to placebo for two-hour pain freedom (25.5% vs 8.9%) but not for two-hour headache response. Per the prespecified multiplicity strategy, this nonsignificant result precluded further formal hypothesis testing, although the 50 mg and 25 mg doses demonstrated nominal significance over placebo for two-hour pain freedom (unadjusted p < 0.05). Overall, adverse events were similar between ubrogepant and placebo.
Conclusion This trial supports ubrogepant’s efficacy and provides further evidence that CGRP-RAs are viable options for the acute treatment of migraine.
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Frontalis Sling for the Treatment of Congenital Ptosis
Today, 7 Ιουνίου 2016,
7 hours ago
In this case, the frontalis sling procedure was used to correct congenital
ptosis of the right upper eyelid.
ePlasty, Open Access Journal of Plastic Surgery
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ePlasty, Open Access Journal of Plastic Surgery
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OtoRhinoLaryngology & Medicine,New Articles,June 7th,2016
Today, 7 Ιουνίου 2016,
7 hours ago | Alexandros Sfakianakis
A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 δευτερόλεπταAim The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute treatment of migraine. Methods This double-blind, placebo-controlled study randomized 834 participants to treat one migraine attack with ubrogepant 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, or placebo in a 1:1 ratio. The co-primary endpoints were pain freedom and headache response at two hours. The first primary hypothesis tested the dose-response trend for two-hour pain freedom using a logistic regression model… περισσότερα »
Frontalis Sling for the Treatment of Congenital Ptosis
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 δευτερόλεπταIn this case, the frontalis sling procedure was used to correct congenital ptosis of the right upper eyelid. *ePlasty, Open Access Journal of Plastic Surgery* from #ENT via xlomafota13 on Inoreader http://ift.tt/1PCJVgL via IFTTT περισσότερα »
Ceramic variation and negotiated communities in the Late Valdivia phase of coastal Ecuador
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Publication date: September 2016 Source:Journal of Anthropological Archaeology, Volume 43 Author(s): Sarah M. Rowe Previous research of prehispanic coastal Ecuador has argued for the development of social hierarchies during the Late Valdivia period (2400–1800 BCE), based on changing regional settlement patterns, increased long-distance exchange, and increasing intra-site differentiation. Recent investigations at Valdivia sites have highlighted […] περισσότερα »
Electronic nicotine delivery system landscape in licensed tobacco retailers: results of a county-level survey in Oklahoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives Electronic nicotine delivery systems (ENDS) have recently emerged as a component of the tobacco retail environment. The aims of this study were to describe the availability, types of ENDS and placement of ENDS relative to traditional tobacco products at franchised licensed tobacco retailers and non-franchised licensed tobacco retailers. Design Observational study. Setting Franchised and […] περισσότερα »
Validation of the Kinyarwanda-version Short-Form Leeds Dyspepsia Questionnaire and Short-Form Nepean Dyspepsia Index to assess dyspepsia prevalence and quality-of-life impact in Rwanda
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives We aimed to develop and validate Kinyarwanda versions of Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) and Short-Form Nepean Dyspepsia Index (SF-NDI) to measure the frequency and severity of dyspepsia and associated quality-of-life impact in Rwanda. Setting A single, tertiary care centre in Rwanda. Participants 200 consecutive Kinyarwanda-speaking patients referred to endoscopy (100 patients) or medical […] περισσότερα »
Default options in advance directives: study protocol for a randomised clinical trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Introduction Although most seriously ill Americans wish to avoid burdensome and aggressive care at the end of life, such care is often provided unless patients or family members specifically request otherwise. Advance directives (ADs) were created to provide opportunities to set limits on aggressive care near life’s end. This study tests the hypothesis that redesigning […] περισσότερα »
Identifying improvements to complex pathways: evidence synthesis and stakeholder engagement in infant congenital heart disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives Many infants die in the year following discharge from hospital after surgical or catheter intervention for congenital heart disease (3–5% of discharged infants). There is considerable variability in the provision of care and support in this period, and some families experience barriers to care. We aimed to identify ways to improve discharge and postdischarge […] περισσότερα »
When procedures meet practice in community pharmacies: qualitative insights from pharmacists and pharmacy support staff
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives Our aim was to explore how members of community pharmacy staff perceive and experience the role of procedures within the workplace in community pharmacies. Setting Community pharmacies in England and Wales. Participants 24 community pharmacy staff including pharmacists and pharmacy support staff were interviewed regarding their view of procedures in community pharmacy. Transcripts were […] περισσότερα »
Clinical outcomes at 12 months and risk of inflammatory bowel disease in patients with an intermediate raised fecal calprotectin: a ‘real-world view
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives A recent systematic review confirmed the usefulness of fecal calprotectin (FC) in distinguishing organic (inflammatory bowel disease (IBD)) from non-organic gastrointestinal disease (irritable bowel syndrome (IBS)). FC levels <50 μg/g have a negative predictive value >92% to exclude organic gastrointestinal (GI) disease. Levels >250 μg/g correlate with endoscopic IBD disease activity; sensitivity 90%. We […] περισσότερα »
Comparing cognitive-behavioural psychotherapy and psychoeducation for non-specific symptoms associated with indoor air: a randomised control trial protocol
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Introduction Indoor air-related conditions share similarities with other conditions that are characterised by medically unexplained symptoms (MUS)-a combination of non-specific symptoms that cannot be fully explained by structural bodily pathology. In cases of indoor air-related conditions, these symptoms are not fully explained by either medical conditions or the immunological–toxicological effects of environmental factors. The condition […] περισσότερα »
Longitudinal trends in use and costs of targeted therapies for common cancers in Taiwan: a retrospective observational study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Objectives Some targeted therapies have improved survival and overall quality of cancer care generally, but these increasingly expensive medicines have led to increases in pharmaceutical expenditure. This study examined trends in use and expenditures of antineoplastic agents in Taiwan, and estimated market shares by prescription volume and costs of targeted therapies over time. We also […] περισσότερα »
Effect of affordable technology on physical activity levels and mobility outcomes in rehabilitation: a protocol for the Activity and MObility UsiNg Technology (AMOUNT) rehabilitation trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπτα
Introduction People with mobility limitations can benefit from rehabilitation programmes that provide a high dose of exercise. However, since providing a high dose of exercise is logistically challenging and resource-intensive, people in rehabilitation spend most of the day inactive. This trial aims to evaluate the effect of the addition of affordable technology to usual care […] περισσότερα »
Retraction notice
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταfrom #ENT via xlomafota13 on Inoreader http://ift.tt/1U5hJBU via IFTTT περισσότερα »
Radioactive Iodine Treatment Is Associated with Improved Survival for Patients with Hürthle Cell Carcinoma
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1U5cmma via IFTTT περισσότερα »
Thyroid Cancer–Specific Quality of Life and Health-Related Quality of Life in Young Adult Thyroid Cancer Survivors
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1tdDzdT via IFTTT περισσότερα »
Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1raND5B via IFTTT περισσότερα »
A chilling reminder: Pediatric facial trauma from recreational winter activities
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταPublication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Peter F. Svider, Michael Bobian, Houmehr Hojjat, Anthony Sheyn, Giancarlo Zuliani, Jean Anderson Eloy, Adam J. Folbe BackgroundWinter activities offer children and adolescents an outdoor recreational opportunity during the coldest months. Our objectives were to estimate the national incidence of facial injury associated with recreational winter activities. Furthermore, we analyze demographic trends and clinical characteristics of patients presenting to emergency depart… περισσότερα »
Sitting 3-D CT in Patients With Patulous Eustachian Tube.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
Relationship Between Clinical Test Results and Morphologic Severity Demonstrated by Sitting 3-D CT in Patients With Patulous Eustachian Tube.: Objective: To investigate the correlation of sitting 3-D computed tomography (CT) scans of the Eustachian tube (ET) with subjective and objective findings in patients with patulous Eustachian tube (PET). Study Design: Retrospective. Setting: Tertiary referral center. […] περισσότερα »
mri Compatibility of a New Generation of Active Middle Ear Implant
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
Magnetic Resonance Imaging Compatibility of a New Generation of Active Middle Ear Implant: A Clinically Relevant Temporal Bone Laboratory Study.: Objective: Magnetic resonance imaging (MRI) has become an essential tool of modern medical imaging and disease diagnosis. In November 2014, a new MRI-conditional (up to 1.5 T) generation of an active middle ear implant (AMEI) […] περισσότερα »
Surgical resection of extensive cholesteatoma with medial involvement of the vertical segment of the facial nerve resulted in an unsupported mastoid segment
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπτα
The Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma.: Objectives/Hypothesis: Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian […] περισσότερα »
Anatomy Pathology 36 Unread articles
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 21 δευτερόλεπτα
SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals Valerie Speirs, Bethny Morrisey, Ingunn Holen, Karen Blyth, Phil Carter, Claude Chelala, Louise Jones · Monday, June 06, 2016, 15:55 Tags: Anatomy Pathology – – – – – Der Pathologe Mitteileungen Bundesverband Deutscher Pathologen Saturday, June 04, 2016, 15:23 Tags: Anatomy Pathology – – – – – Der Pathologe Mitteilungen der ÖGPath/IAP Austria Saturday, June 04, 2016, 15:23 Tags: Anatomy Pathology – – … περισσότερα »
Anatomy Pathology 38 Unread articles
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 21 δευτερόλεπτα
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology Hallin, M., Schneider, N., Thway, K. · Tuesday, June 07, 2016, 7:54 Well-differentiated liposarcoma (WDL) can show a morphologic spectrum, including lipoma-like, sclerosing and inflammatory subtypes. It does not metastasize but can dedifferentiate, acquiring metastatic potential. Hibernomas are benign neoplasms that show variable differentiation toward brown fat, and can sometimes occur in the abdomen or retroperitoneum. We illustrate a case of retroperitoneal WDL that showed extensive hibernoma-like morphology, with shee… περισσότερα »
Physiology 41 Unread articles
Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 21 δευτερόλεπταMelatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells Monday, June 06, 2016, 23:55 Abstract Melatonin is a hormone that is mainly secreted by the pineal gland and exhibits a wide spectrum of activities, including antioxidant functions. Melatonin has been detected in gingival crevicular fluid. However, the role of melatonin in periodontal tissue is still uncertain. The aim of this study was to examine the effects of melatonin on inflammatory mediator expression in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CXC c… περισσότερα »
Dental Prosthesis for a Young Cleft Lip and Palate Patient
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταModified PEEK Resin Bonded Fixed Dental Prosthesis for a Young Cleft Lip and Palate Patient: Abstract Objective This clinical report presents the use of a modified poly ether–ether ketone material as an alternative material for the fabrication of resin-bonded fixed dental prosthesis (RBFDP) framework. This new material can be used for patients allergic to metals, maintaining the same high esthetic demand of ceramics, presenting light weightness and a flexibility similar to bone as a distinct advantage over ceramic materials. Conclusions The use of a BioHPP RBFDP framework could be c… περισσότερα »
How the demographic makeup of our community influences speech perception
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα
How the demographic makeup of our community influences speech perception: [image: cm_sbs_024_plain.png] Speech perception is known to be influenced by listeners’ expectations of the speaker. This paper tests whether the demographic makeup of individuals’ communities can influence their perception of foreign sounds by influencing their expectations of the language. Using online experiments with participants from all across the U.S. and matched census data on the proportion of Spanish and other foreign language speakers in participants’ communities, this paper shows that the demograp… περισσότερα »
Gait & Posture : Children with cerebral palsy
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταexperience greater levels of loading at the low back during gait compared to healthy controls” via Gait & Posture Publication date: Available online 6 June 2016 *Source:*Gait & Posture Author(s): D. Kiernan, A. Malone, T. O’Brien, C.K. Simms Excessive trunk motion has been shown to be characteristic of cerebral palsy (CP) gait. However, the associated demands on the lower spine are unknown. This study investigated 3-dimensional reactive forces and moments at the low back in CP children compared to healthy controls. In addition, the impact of functional level of impairment was investi… περισσότερα »
Secondary Acquired Cholesteatoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταPresentation and Tympanoplasty Outcomes.: Objective: Comparing the clinical features and surgical outcomes of patients undergoing tympanoplasty for secondary acquired cholesteatoma (SAC) versus non-complicated tympanic membrane perforation (TMP). Study Design: Retrospective patient review. Setting: Tertiary-care, academic center. Patients: All 41 patients with diagnosis of SAC confirmed at surgery between January 1, 2007 and June 30, 2014, and an age-matched cohort consisting of patients with TMP. Intervention(s): Tympanoplasty using either medial or lateral graft techniques. Ma… περισσότερα »
The Pars Inferior of the Human Inner Ear : Focal Endolymphatic Hydrops
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταFocal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear.: Hypothesis: Endolymphatic hydrops of the human inner ear may be localized focally in the pars inferior of the human inner ear. Background: Endolymphatic hydrops may be found in the human inner ear in patients who in life had suffered from Meniere’s syndrome or a variety of other disorders. The degree of endolymphatic hydrops may differ based on location in the inner ear. Methods: A computer-assisted search of all cases in the collection of the Massachusetts Eye and Ear Infirmary in which endolymphatic … περισσότερα »
The Pars Inferior of the Human Inner Ear
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταFocal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear.: Hypothesis: Endolymphatic hydrops of the human inner ear may be localized focally in the pars inferior of the human inner ear. Background: Endolymphatic hydrops may be found in the human inner ear in patients who in life had suffered from Meniere’s syndrome or a variety of other disorders. The degree of endolymphatic hydrops may differ based on location in the inner ear. Methods: A computer-assisted search of all cases in the collection of the Massachusetts Eye and Ear Infirmary in which endolymphatic … περισσότερα »
Cochlear Implantation in Schwannomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταCochlear Implantation in Patients With Intracochlear and Intralabyrinthine Schwannomas.: Objective: Schwannomas may arise primarily within the inner ear, or invade the cochlea or labyrinth from the distal internal auditory canal through transmodiolar or transmacular extension, respectively. To date, very limited data exists regarding cochlear implant (CI) outcomes in this unique population. Study Design: Retrospective case review. Patients: Ten ears (nine patients) with inner ear schwannomas that underwent CI at a single tertiary referral center. Intervention(s): Cochlear implantat… περισσότερα »
Cochlear Histopathology
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταas Observed in Two Patients With a Cochlear Implant Electrode With Positioner.: Hypothesis: This study reports the cochlear histopathology of two patients who during life underwent cochlear implantation with a positioner. Background: A silastic positioner introduced by the Advanced Bionics Corporation in 1999 was designed to position the electrode of the cochlear implant close to the modiolus. The positioner was recalled in the United States in July 2002 because of an apparent higher incidence of bacterial meningitis in patients in whom the positioner had been placed. Methods: Fou… περισσότερα »
Type I Tympanoplasty
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταMeta-Analysis: A Single Variable Analysis.: Objective: To determine which independent variables influencing the efficacy of type I tympanoplasty in adult and pediatric populations. Data Sources: A search of the PubMed database and Cochrane Database of Systematic Reviews using the key words “tympanoplasty OR myringoplasty” from January 1966 to July 2014 was performed. Study Selection: Studies reporting outcomes of myringoplasty or Type I tympanoplasty in primary non-cholesteatomatous chronic tympanic membrane (TM) perforation were included. Data Extraction: Of 4,698 abstracts revie… περισσότερα »
TeleAudiology
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταin the Veterans Health Administration.: Objective: To assess effectiveness of TeleAudiology for hearing aid services. Study Design: Retrospective case-control. Setting: Ambulatory Veterans Health Administration and Community-Based Outpatient Clinics (CBOCs). Patients: 42,697 veterans who received hearing aids from January through September, 2014. Intervention(s): TeleAudiology (TA) and conventional in-person (IP) audiology care. Main Outcome Measure(s): International Outcome Inventory for Hearing Aids (IOI-HA) outcomes data. The IOI-HA is a 7-item survey used to assess hearing a… περισσότερα »
Petroclival Chondrosarcoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταA Multicenter Review of 55 Cases and New Staging System.: Objective: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. Study Design: Retrospective case review, 1995 to 2015. Setting: Multicenter study. Patients: Consecutive patients with histopathologically proven petroclival chondrosarcoma. Intervention(s): Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. Main Outcome Measures: Disease- and treatment-associated morbidity, recurrence, mortality. Results: Fifty-five patients (mean age 42 ye… περισσότερα »
Tissue Preservation Surgical Techniques in Percutaneous Bone Conduction Hearing Devices.
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταA Systematic Review on Complications of Tissue Preservation Surgical Techniques in Percutaneous Bone Conduction Hearing Devices.: Objective: To investigate skin-related postoperative complications from tissue preservation approaches in percutaneous bone conduction device (BCD) implantations. Data Sources: PubMed, Embase, and Cochrane Library. Study Selection: We identified studies on BCDs including the opted surgical technique and derived complications. Retrieved articles were screened using predefined inclusion criteria. Critical appraisal included directness of evidence and risk … περισσότερα »
Botulinum Toxin Treatment of Objective Tinnitus
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταBotulinum Toxin Treatment of Objective Tinnitus Because of Essential Palatal Tremor: A Systematic Review.: Introduction: In contrast to subjective tinnitus, objective tinnitus can be heard by the examiner as well as by the patient. It can be triggered by, among many other etiologies, idiopathic muscular tremor in the soft palate, the essential palatal tremor (EPT). Many treatment modalities have been investigated, of which only Botulinum toxin (BT) injections have shown promising results. Goal: The aim of this study was to evaluate the effect of BT treatment on objective tinnitus du… περισσότερα »
Botulinum Toxin Treatment of Essential Palatal Tremor
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταBotulinum Toxin Treatment of Objective Tinnitus Because of Essential Palatal Tremor: A Systematic Review.: Introduction: In contrast to subjective tinnitus, objective tinnitus can be heard by the examiner as well as by the patient. It can be triggered by, among many other etiologies, idiopathic muscular tremor in the soft palate, the essential palatal tremor (EPT). Many treatment modalities have been investigated, of which only Botulinum toxin (BT) injections have shown promising results. Goal: The aim of this study was to evaluate the effect of BT treatment on objective tinnitus du… περισσότερα »
Ossiculoplasty Outcomes and Complications
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταThe Association of Valsalva Status With Smoking and Its Impact on Ossiculoplasty Outcomes and Complications.: Objectives: To assess the association of a patient’s ability to perform a clinically observed Valsalva maneuver with tobacco smoking and post-ossiculoplasty outcomes. Study Design: Case series with chart review. Setting: Tertiary referral, university-based otology practice. Patients: Adult patients (16-88 years of age) undergoing ossiculoplasty with tympanoplasty or tympanomastoidectomy using cartilage tympanic membrane grafts, retrograde mastoidectomy with canal wall recons… περισσότερα »
Asymmetrical hearing loss accounted for between 2.4% and 22.6% of NIHL cases (L-R difference >15 dB for any frequency 0.5-8 kHz)
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταAsymmetrical Hearing Loss in Cases of Industrial Noise Exposure: A Systematic Review of the Literature.: Objective: Asymmetrical hearing thresholds are common in people claiming compensation for noise-induced hearing loss (NIHL). When present and otherwise unexplained, there is some controversy as to whether such asymmetry can be attributed to occupational noise exposure. In this review, our main objectives were to collate the overall prevalence of this finding in subjects with NIHL, and further, to provide a balanced argument regarding causality. Data Sources: MEDLINE, CINAHL, EMBA… περισσότερα »
Primary Epidermoid Tumors of the Cerebellopontine Angle
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταA Review of 47 Cases.: Objective: To analyze disease presentation, treatment, and clinical course of a consecutive series of patients with primary cerebellopontine angle (CPA) epidermoids. Patients: Forty-seven consecutive patients with previously untreated CPA epidermoids. Intervention(s): Observation and microsurgery. Main Outcome Measures: Disease- and treatment-associated morbidity, recurrence. Results: Forty-seven patients (mean age 39 years; 53% women) were analyzed and the average duration of follow-up was 42 months. The most common presenting symptom was headache (27; 57%)… περισσότερα »
Sitting 3-D CT in Patients With Patulous Eustachian Tube.
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταRelationship Between Clinical Test Results and Morphologic Severity Demonstrated by Sitting 3-D CT in Patients With Patulous Eustachian Tube.: Objective: To investigate the correlation of sitting 3-D computed tomography (CT) scans of the Eustachian tube (ET) with subjective and objective findings in patients with patulous Eustachian tube (PET). Study Design: Retrospective. Setting: Tertiary referral center. Subjects: A retrospective survey of medical records in Sen-En Hospital identified 40 patients and 62 ears with PET between September 2014 and June 2015. Method: Diagnosis of PE… περισσότερα »
mri Compatibility of a New Generation of Active Middle Ear Implant
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταMagnetic Resonance Imaging Compatibility of a New Generation of Active Middle Ear Implant: A Clinically Relevant Temporal Bone Laboratory Study.: Objective: Magnetic resonance imaging (MRI) has become an essential tool of modern medical imaging and disease diagnosis. In November 2014, a new MRI-conditional (up to 1.5 T) generation of an active middle ear implant (AMEI) was released to the market. The aim of the study was to test the MRI compatibility of the new implant system in a clinical-anatomical study. Design: Experimental cadaver head model. Setting: Temporal bone laboratory…. περισσότερα »
Surgical resection of extensive cholesteatoma with medial involvement of the vertical segment of the facial nerve resulted in an unsupported mastoid segment
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταThe Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma.: Objectives/Hypothesis: Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian canal of the facial nerve. Extensive disease may extend to the posterior and middle fossa dura, the otic capsule, the carot… περισσότερα »
Flat-Panel CT Imaging for Individualized Pitch Mapping
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταin Cochlear Implant Users.: Objective: This study aims to identify electrode contact location and to assess frequency deviation between predicted and actual frequency allocation maps in cochlear implant (CI) users. Study Design and Methods: This is a retrospective clinical study. Flat-panel computed tomography (FPCT) scans were collected for 17 CI users. Cochlear length was measured using three-dimensional curved multiplanar reconstruction on high-resolution secondary reconstructions. Each electrode’s percentage of distance from the base of the helicotrema was measured, and a modi… περισσότερα »
Ossiculoplasty
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταThe Impact of Smoking on Ossiculoplasty Outcomes.: Objectives: To assess the impact of tobacco smoking on outcomes after ossiculoplasty. Study Design: Case series with chart review. Setting: Tertiary care center. Patients: Adult patients (16-88 yr of age) undergoing ossiculoplasty with cartilage tympanoplasty. Outcome Measures: Patients were classified as smokers (TOB+) or nonsmokers (TOBN). Comparisons were then made between these two groups with regard to early and late audiometric outcomes, rate of cure of conductive hearing loss, rate of successful graft healing, and incidence … περισσότερα »
ABI in Children with Severe Inner Ear Malformations.
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταLong-term Results of Objective: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. Study Design: Retrospective chart review. Setting: Tertiary referral otolaryngology clinic. Subjects and Methods: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status. The surgeries were performed via retro… περισσότερα »
Auditory Brainstem Implantation in Neurofibromatosis Type II
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταAuditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.: Objective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after acti… περισσότερα »
Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα2h The Genomic Data Commons Launches Making genomic and clinical data about cancer accessible to the cancer research community is imperative for our success in applying precision medicine to clinical oncology. The NCI Genomic Data Commons (GDC), released today, brings us a step closer to realizing this goal.By analyzing large sets of shared… 2h Tumor Microenvironment Influences Metabolism of Cancer Cells When we think about tumor heterogeneity, we often imagine variation that originates from genetic and/or epigenetic mechanisms. However, there is increasing evidence that varia… περισσότερα »
Freehand three-dimensional ultrasound to assess semitendinosus muscle morphology
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπτα
Abstract In several neurological disorders and muscle injuries, morphological changes of the m. semitendinosus (ST) are presumed to contribute to movement limitations around the knee. Freehand three-dimensional (3D) ultrasound (US), using position tracking of two-dimensional US images to reconstruct a 3D voxel array, can be used to assess muscle morphology in vivo. The aims of […] περισσότερα »
Retraction notice
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 34 δευτερόλεπταfrom Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1U5hJBU περισσότερα »
Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Patricia T Illing | Nicole A Mifsud | Anthony W Purcell from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1VJ2HEj περισσότερα »
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Karlynn E Neu | Carole J Henry Dunand | Patrick C Wilson from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1VJ1wVs περισσότερα »
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Karlynn E Neu | Carole J Henry Dunand | Patrick C Wilson from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ1wVs via IFTTT περισσότερα »
Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Patricia T Illing | Nicole A Mifsud | Anthony W Purcell from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ2HEj via IFTTT περισσότερα »
New concepts in HIV-1 vaccine development
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Kathryn E Stephenson | Helen T D’Couto | Dan H Barouch from #ENT via xlomafota13 on Inoreader http://ift.tt/1TSJ47Y via IFTTT περισσότερα »
Auditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπταObjective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after activation. Environmental sounds could be differentiated by six (75%) patients after 6 months of ABI use (mean score… περισσότερα »
Long-term Results of ABI in Children with Severe Inner Ear Malformations.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπταObjective: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. Study Design: Retrospective chart review. Setting: Tertiary referral otolaryngology clinic. Subjects and Methods: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status. The surgeries were performed via retrosigmoid approach with a… περισσότερα »
The Impact of Smoking on Ossiculoplasty Outcomes.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπταObjectives: To assess the impact of tobacco smoking on outcomes after ossiculoplasty. Study Design: Case series with chart review. Setting: Tertiary care center. Patients: Adult patients (16-88 yr of age) undergoing ossiculoplasty with cartilage tympanoplasty. Outcome Measures: Patients were classified as smokers (TOB+) or nonsmokers (TOBN). Comparisons were then made between these two groups with regard to early and late audiometric outcomes, rate of cure of conductive hearing loss, rate of successful graft healing, and incidence of complications after surgery. Results: There was n… περισσότερα »
Flat-Panel CT Imaging for Individualized Pitch Mapping in Cochlear Implant Users.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπταObjective: This study aims to identify electrode contact location and to assess frequency deviation between predicted and actual frequency allocation maps in cochlear implant (CI) users. Study Design and Methods: This is a retrospective clinical study. Flat-panel computed tomography (FPCT) scans were collected for 17 CI users. Cochlear length was measured using three-dimensional curved multiplanar reconstruction on high-resolution secondary reconstructions. Each electrode’s percentage of distance from the base of the helicotrema was measured, and a modified Greenwood’s function was … περισσότερα »
Radioactive Iodine Treatment Is Associated with Improved Survival for Patients with Hürthle Cell Carcinoma
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1U5cmma via IFTTT περισσότερα »
Thyroid Cancer–Specific Quality of Life and Health-Related Quality of Life in Young Adult Thyroid Cancer Survivors
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1tdDzdT via IFTTT περισσότερα »
Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1raND5B via IFTTT περισσότερα »
A chilling reminder: Pediatric facial trauma from recreational winter activities
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταPublication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Peter F. Svider, Michael Bobian, Houmehr Hojjat, Anthony Sheyn, Giancarlo Zuliani, Jean Anderson Eloy, Adam J. Folbe BackgroundWinter activities offer children and adolescents an outdoor recreational opportunity during the coldest months. Our objectives were to estimate the national incidence of facial injury associated with recreational winter activities. Furthermore, we analyze demographic trends and clinical characteristics of patients presenting to emergency depart… περισσότερα »
Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα[image: S09527915.gif] Patricia T Illing | Nicole A Mifsud | Anthony W Purcell from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ2HEj via IFTTT περισσότερα »
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα[image: S09527915.gif] Karlynn E Neu | Carole J Henry Dunand | Patrick C Wilson from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ1wVs via IFTTT περισσότερα »
New concepts in HIV-1 vaccine development
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα[image: S09527915.gif] Kathryn E Stephenson | Helen T D’Couto | Dan H Barouch from #ENT via xlomafota13 on Inoreader http://ift.tt/1TSJ47Y via IFTTT περισσότερα »
Auditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταObjective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after activation. Environmental sounds could be differentiated by six (75%) patients after 6 months of ABI use (mean score… περισσότερα »
The association of Red cell distribution width and in-hospital mortality in older adults admitted to the emergency department
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώραThe objective of the study was to test the hypothesis that elevated red cell distribution width (RDW) at admission increases the risk of mortality in older patients admitted to the emergency department (ED). from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1Xz7070 περισσότερα »
The association of Red cell distribution width and in-hospital mortality in older adults admitted to the emergency department
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώραThe objective of the study was to test the hypothesis that elevated red cell distribution width (RDW) at admission increases the risk of mortality in older patients admitted to the emergency department (ED). from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1Xz7070 via IFTTT περισσότερα »
Rhizobium leguminosarum symbiovar trifolii, Ensifer numidicus, and Mesorhizobium amorphae symbiovar ciceri (or Mesorhizobium loti) are new endosymbiotic bacteria of Lens culinaris Medik
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
142 rhizobial bacteria were isolated from root nodules of Lens culinaris Medik endemic to Tunisia and they belonged to the species Rhizobium leguminosarum and for the first time to Ensifer and Mesorhizobium, genera never previously described as microsymbionts of lentil. Phenotypically, our results indicate that Lens culinaris Medik strains showed heterogenic responses to the different […] περισσότερα »
Methane release from sediment seeps to the atmosphere is counteracted by highly active Methylococcaceae in the water column of deep oligotrophic Lake Constance
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Methane emissions from freshwater environments contribute substantially to global warming but are under strong control of aerobic methane-oxidizing bacteria. Recently discovered methane seeps (pockmarks) in freshwater lake sediments have the potential to bypass this control by their strong outgasing activity. Whether this is counteracted by pelagic methanotrophs is not well understood yet. We used a […] περισσότερα »
Subalpine conifers in two different geographic locations host highly similar foliar bacterial endophyte communities.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Pines in the subalpine environment at Niwot Ridge, CO have been found to host communities of acetic acid bacteria (AAB) within their needles. The significance and ubiquity of this pattern is not known, but recent evidence of nitrogen (N)-fixing activity inside Pinus flexilis (limber pine) foliage calls for a better understanding of the processes that […] περισσότερα »
Benthic protists: the under-charted majority
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Marine protist diversity inventories have largely focused on planktonic environments, while benthic protists have received relatively little attention. We therefore hypothesize that current diversity surveys have only skimmed the surface of protist diversity in marine sediments, which may harbour greater diversity than planktonic environments. We tested this by analyzing sequences of the hypervariable V4 18S […] περισσότερα »
Reply: Perifascicular necrosis in anti-synthetase syndrome beyond anti-Jo-1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Yc3VIR via IFTTT περισσότερα »
Perifascicular necrosis in anti-synthetase syndrome beyond anti-Jo-1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1t3VVxe via IFTTT περισσότερα »
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Mutations in brain isoforms of voltage-gated sodium channels have been identified in patients with distinct epileptic phenotypes. Clinically, these patients often do not respond well to classic anti-epileptics and many remain refractory to treatment. Exogenous as well as endogenous cannabinoids have been shown to target voltage-gated sodium channels and cannabidiol has recently received attention for […] περισσότερα »
Distinct Oral Neutrophil Subsets Define Health and Periodontal Disease States
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Neutrophils exit the vasculature and swarm to sites of inflammation and infection. However, these cells are abundant in the healthy, inflammation-free human oral environment, suggesting a unique immune surveillance role within the periodontium. We hypothesize that neutrophils in the healthy oral cavity occur in an intermediary parainflammatory state that allows them to interact with and […] περισσότερα »
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Well-differentiated liposarcoma (WDL) can show a morphologic spectrum, including lipoma-like, sclerosing and inflammatory subtypes. It does not metastasize but can dedifferentiate, acquiring metastatic potential. Hibernomas are benign neoplasms that show variable differentiation toward brown fat, and can sometimes occur in the abdomen or retroperitoneum. We illustrate a case of retroperitoneal WDL that showed extensive hibernoma-like […] περισσότερα »
Evidence for a Notch1-mediated transition during olfactory ensheathing cell development
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Olfactory ensheathing cells (OECs) are a unique glial population found in both the peripheral and central nervous system: they ensheath bundles of unmyelinated olfactory axons from their peripheral origin in the olfactory epithelium to their central synaptic targets in the glomerular layer of the olfactory bulb. Like all other peripheral glia (Schwann cells, satellite […] περισσότερα »
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«Music Therapy Helped Me Get Back Doing»: Perspectives of Music Therapy Participants in Mental Health Services
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: Mental health service development internationally is increasingly informed by the collaborative ethos of recovery. Service user evaluation of experiences within music therapy programs allows new phenomena about participation in services to be revealed that might otherwise remain unnoticed. Objective: The aim of this study was to demonstrate how asking service users about their experience… Continue reading «Music Therapy Helped Me Get Back Doing»: Perspectives of Music Therapy Participants in Mental Health Services περισσότερα »
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Vocal Music Therapy for Chronic Pain Management in Inner-City African Americans: A Mixed Methods Feasibility Study
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: To date, research on music for pain management has focused primarily on listening to prerecorded music for acute pain. Research is needed on the impact of active music therapy interventions on chronic pain management. Objective: The aim of this mixed methods research study was to determine feasibility and estimates of effect of vocal music… Continue reading Vocal Music Therapy for Chronic Pain Management in Inner-City African Americans: A Mixed Methods Feasibility Study περισσότερα »
Obscure Retropharyngeal Mucocutaneous Masses Associated With Acoustic Neurofibromatosis: A Source of Difficult Airway Management.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
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The Power of Raw Data.
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Cerebral Oxygenation Under General Anesthesia Can Be Safely Preserved in Patients in Prone Position: A Prospective Observational Study.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώρα
Background: The effects of prone position (PP) on cerebral tissue metabolism are not well known. The aim of this investigation was to evaluate regional cerebral oxygen desaturation in patients undergoing lumbar spine surgery in PP during routine anesthesia management. Materials and Methods: Between July 2013 and October 2013, 50 consecutive patients undergoing lumbar spine surgery… Continue reading Cerebral Oxygenation Under General Anesthesia Can Be Safely Preserved in Patients in Prone Position: A Prospective Observational Study. περισσότερα »
Anesthetic Challenges in the Management of Distal Posterior Cerebral Artery Aneurysm for Surgical Clipping: A Report of 2 Cases.
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Using the Swiss ball versus peanut ball to assess the back extensors endurance among healthy collegiate physical therapy students at Taibah University
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες2016-06-06T19-38-22Z *Source:* International Journal of Therapies and Rehabilitation Research Tarek Mohamed El-gohary; Osama A. Khaled. Spinal extensors endurance is a vital and fundamental pillar for the general endurance. Good endurance helps in injury prevention, and improves efficiency in all physical activities across different ages. Endurance testing of back extensors has been extensively examined in literature but there are many criticisms to the suitability and the practicality of the commonly used tests. The purpose of this study was to compare the endurance ability of the tr… περισσότερα »
Distribution of IL28B Polymorphism in a Cohort of Italians and Immigrants with HCV Infection: Association with Viraemia, Stage of Fibrosis and Response to Treatment
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρεςAbstract Aims of the study are to investigate, in a cohort of patients affected by HCV chronic hepatitis with genotypes 1 and 4, the prevalence of interleukin 28B (IL28B) genotypes, the possible association between IL28B polymorphism and severity of liver damage, the role of IL28B CC as a predictor of outcome. 365 patients with HCV infection were observed between 2013 and 2014. Demographic, virological, biochemical, and genetic characteristics of each patient were investigated. Liver fibrosis was assessed by transient elastometry. Mean age of the patients (72.9 % males, 27.1 % femal… περισσότερα »
Indigenous Adolescents’ Suicidal Behaviors and Risk Factors: Evidence from the National Youth Risk Behavior Survey
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρεςAbstract The study sought to examine indigenous adolescents’ suicidal behaviors and risk factors in a nationally representative sample and explore potential causes of disparities. The study analyzed the 1991–2013 Youth Risk Behavior Survey National Combined Datasets. Suicidal behavior outcomes included suicide consideration, planning, and attempts during the past 12 months. Logit regressions were used to estimate the effects of potential suicide risk factors on these suicidal behaviors. The results showed that a high percentage of indigenous adolescents exhibited suicidal behaviors … περισσότερα »
Ethnic Disparities in Blood Pressure: A Population-based Study
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρεςAbstract Taiwan’s indigenous population exhibits a higher mortality of cardiovascular disease, but current research has not reported any associations among ethnicities on the blood pressure (BP). We randomly selected representative samples in this population-based study. We measured height, weight, hip and waist circumferences, and blood pressure in a screening survey. Systolic BP and diastolic BP were significantly higher in the indigenous population. Among women, prevalence rates of DBP > 90 mmHg among indigenes (32.9 %) were significantly high than those in Han Chinese (17.4 %)…. περισσότερα »
Supernumerary renal vessels: analysis of frequency and configuration in 996 computed tomography studies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background: Number, course and division pattern of renal vessels is highly variable. Variant renal vasculature is of high interest in nephrectomy for the renal transplantations, both in deceased and living donors. The purpose of the study was to analyse the frequency of supernumerary renal vessels in a large cohort of patients undergoing the multiphase abdominopelvic […] περισσότερα »
Cone beam computed tomography investigation of the antral artery anastomosis in a population of Central Italy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background: The arterial vascular supply of maxillary sinus has to be considered in all the surgical procedures where it is involved. In particular, the intraosseous anastomosis between the posterior superior alveolar artery and the infraorbital artery branches in the bony canal can be tricky to a not well aware clinician. The aim of this study […] περισσότερα »
Morphological characteristics of the sinus node on postmortem tissue
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The sinus node is an intensively researched structure in terms of anatomical, histological, electrophysiological, molecular and genetic approach. For postmortem diagnosis it is still difficult to investigate due to a still reduced accessibility. In this study we tried and succeed to apply molecular biology techniques on postmortem tissues in order to widen the range of […] περισσότερα »
A cephalic vein drained into one of the double axillary veins through the pectoralis major muscle
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Although the cephalic vein follows a fairly consistent course, numerous variants have been reported. We found a rare anatomical presentation of the cephalic vein in a 43-year-old Korean male cadaver. The cephalic vein had anastomosed with the basilic vein and brachial vein at the level of the elbow, perforated the pectoralis major muscle between the […] περισσότερα »
Porcine liver vascular bed in Biodur E20 corrosion casts
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Background: Pigs are frequently used as animal models in experimental medicine. To identify processes of vascular development or regression, vascular elements must be recognised and quantified in a three-dimensional (3D) arrangement. Vascular corrosion casts enable the creation of 3D replicas of vascular trees. The aim of our study was to identify suitable casting media and […] περισσότερα »
Lymphatic vessels around the uterus: D2-40 (podoplandin) immunohistochemistry using elderly cadavers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Using D2-40 immunohistochemistry, we examined the morphology of lymphatic vessels (LVs) in, along and around the uterus of 10 donated female cadavers (mean age, 85 years). All these women had 1 or 2 children with vaginal delivery, but the other obstetrics information was unknown. When compared with the bladder, vagina and the subperitoneal tissue, the […] περισσότερα »
Fine structure of the dorsal lingual epithelium in Tarentola annularis and Crocodylus niloticus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρες
The present study examined the morphological features, histological and histochemical aspect of the tongue of two reptilian species, Tarentola annularis (family: Gekkonidae) and Crocodylus niloticus (family: Crocodylidea), with different habitats, feeding patterns and behaviours, by light and scanning electron microscope. It was observed, that the bifurcation of the tongue was more visible in Tarentola annularis. […]
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OtoRhinoLaryngology & Medicine,New Articles,June 7th,2016
Today, 7 Ιουνίου 2016,
7 hours ago | Alexandros Sfakianakis
A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 δευτερόλεπταAim The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA), for the acute treatment of migraine. Methods This double-blind, placebo-controlled study randomized 834 participants to treat one migraine attack with ubrogepant 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, or placebo in a 1:1 ratio. The co-primary endpoints were pain freedom and headache response at two hours. The first primary hypothesis tested the dose-response trend for two-hour pain freedom using a logistic regression model… περισσότερα »
Frontalis Sling for the Treatment of Congenital Ptosis
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 2 δευτερόλεπταIn this case, the frontalis sling procedure was used to correct congenital ptosis of the right upper eyelid. *ePlasty, Open Access Journal of Plastic Surgery* from #ENT via xlomafota13 on Inoreader http://ift.tt/1PCJVgL via IFTTT περισσότερα »
Ceramic variation and negotiated communities in the Late Valdivia phase of coastal Ecuador
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταPublication date: September 2016 Source:Journal of Anthropological Archaeology, Volume 43 Author(s): Sarah M. Rowe Previous research of prehispanic coastal Ecuador has argued for the development of social hierarchies during the Late Valdivia period (2400–1800 BCE), based on changing regional settlement patterns, increased long-distance exchange, and increasing intra-site differentiation. Recent investigations at Valdivia sites have highlighted […] περισσότερα »
Electronic nicotine delivery system landscape in licensed tobacco retailers: results of a county-level survey in Oklahoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταObjectives Electronic nicotine delivery systems (ENDS) have recently emerged as a component of the tobacco retail environment. The aims of this study were to describe the availability, types of ENDS and placement of ENDS relative to traditional tobacco products at franchised licensed tobacco retailers and non-franchised licensed tobacco retailers. Design Observational study. Setting Franchised and […] περισσότερα »
Validation of the Kinyarwanda-version Short-Form Leeds Dyspepsia Questionnaire and Short-Form Nepean Dyspepsia Index to assess dyspepsia prevalence and quality-of-life impact in Rwanda
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταObjectives We aimed to develop and validate Kinyarwanda versions of Short-Form Leeds Dyspepsia Questionnaire (SF-LDQ) and Short-Form Nepean Dyspepsia Index (SF-NDI) to measure the frequency and severity of dyspepsia and associated quality-of-life impact in Rwanda. Setting A single, tertiary care centre in Rwanda. Participants 200 consecutive Kinyarwanda-speaking patients referred to endoscopy (100 patients) or medical […] περισσότερα »
Default options in advance directives: study protocol for a randomised clinical trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταIntroduction Although most seriously ill Americans wish to avoid burdensome and aggressive care at the end of life, such care is often provided unless patients or family members specifically request otherwise. Advance directives (ADs) were created to provide opportunities to set limits on aggressive care near life’s end. This study tests the hypothesis that redesigning […] περισσότερα »
Identifying improvements to complex pathways: evidence synthesis and stakeholder engagement in infant congenital heart disease
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταObjectives Many infants die in the year following discharge from hospital after surgical or catheter intervention for congenital heart disease (3–5% of discharged infants). There is considerable variability in the provision of care and support in this period, and some families experience barriers to care. We aimed to identify ways to improve discharge and postdischarge […] περισσότερα »
When procedures meet practice in community pharmacies: qualitative insights from pharmacists and pharmacy support staff
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταObjectives Our aim was to explore how members of community pharmacy staff perceive and experience the role of procedures within the workplace in community pharmacies. Setting Community pharmacies in England and Wales. Participants 24 community pharmacy staff including pharmacists and pharmacy support staff were interviewed regarding their view of procedures in community pharmacy. Transcripts were […] περισσότερα »
Clinical outcomes at 12 months and risk of inflammatory bowel disease in patients with an intermediate raised fecal calprotectin: a ‘real-world view
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταObjectives A recent systematic review confirmed the usefulness of fecal calprotectin (FC) in distinguishing organic (inflammatory bowel disease (IBD)) from non-organic gastrointestinal disease (irritable bowel syndrome (IBS)). FC levels <50 μg/g have a negative predictive value >92% to exclude organic gastrointestinal (GI) disease. Levels >250 μg/g correlate with endoscopic IBD disease activity; sensitivity 90%. We […] περισσότερα »
Comparing cognitive-behavioural psychotherapy and psychoeducation for non-specific symptoms associated with indoor air: a randomised control trial protocol
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταIntroduction Indoor air-related conditions share similarities with other conditions that are characterised by medically unexplained symptoms (MUS)-a combination of non-specific symptoms that cannot be fully explained by structural bodily pathology. In cases of indoor air-related conditions, these symptoms are not fully explained by either medical conditions or the immunological–toxicological effects of environmental factors. The condition […] περισσότερα »
Longitudinal trends in use and costs of targeted therapies for common cancers in Taiwan: a retrospective observational study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταObjectives Some targeted therapies have improved survival and overall quality of cancer care generally, but these increasingly expensive medicines have led to increases in pharmaceutical expenditure. This study examined trends in use and expenditures of antineoplastic agents in Taiwan, and estimated market shares by prescription volume and costs of targeted therapies over time. We also […] περισσότερα »
Effect of affordable technology on physical activity levels and mobility outcomes in rehabilitation: a protocol for the Activity and MObility UsiNg Technology (AMOUNT) rehabilitation trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 18 δευτερόλεπταIntroduction People with mobility limitations can benefit from rehabilitation programmes that provide a high dose of exercise. However, since providing a high dose of exercise is logistically challenging and resource-intensive, people in rehabilitation spend most of the day inactive. This trial aims to evaluate the effect of the addition of affordable technology to usual care […] περισσότερα »
Retraction notice
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταfrom #ENT via xlomafota13 on Inoreader http://ift.tt/1U5hJBU via IFTTT περισσότερα »
Radioactive Iodine Treatment Is Associated with Improved Survival for Patients with Hürthle Cell Carcinoma
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1U5cmma via IFTTT περισσότερα »
Thyroid Cancer–Specific Quality of Life and Health-Related Quality of Life in Young Adult Thyroid Cancer Survivors
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1tdDzdT via IFTTT περισσότερα »
Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1raND5B via IFTTT περισσότερα »
A chilling reminder: Pediatric facial trauma from recreational winter activities
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 18 δευτερόλεπταPublication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Peter F. Svider, Michael Bobian, Houmehr Hojjat, Anthony Sheyn, Giancarlo Zuliani, Jean Anderson Eloy, Adam J. Folbe BackgroundWinter activities offer children and adolescents an outdoor recreational opportunity during the coldest months. Our objectives were to estimate the national incidence of facial injury associated with recreational winter activities. Furthermore, we analyze demographic trends and clinical characteristics of patients presenting to emergency depart… περισσότερα »
Sitting 3-D CT in Patients With Patulous Eustachian Tube.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπταRelationship Between Clinical Test Results and Morphologic Severity Demonstrated by Sitting 3-D CT in Patients With Patulous Eustachian Tube.: Objective: To investigate the correlation of sitting 3-D computed tomography (CT) scans of the Eustachian tube (ET) with subjective and objective findings in patients with patulous Eustachian tube (PET). Study Design: Retrospective. Setting: Tertiary referral center. […] περισσότερα »
mri Compatibility of a New Generation of Active Middle Ear Implant
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπταMagnetic Resonance Imaging Compatibility of a New Generation of Active Middle Ear Implant: A Clinically Relevant Temporal Bone Laboratory Study.: Objective: Magnetic resonance imaging (MRI) has become an essential tool of modern medical imaging and disease diagnosis. In November 2014, a new MRI-conditional (up to 1.5 T) generation of an active middle ear implant (AMEI) […] περισσότερα »
Surgical resection of extensive cholesteatoma with medial involvement of the vertical segment of the facial nerve resulted in an unsupported mastoid segment
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 20 δευτερόλεπταThe Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma.: Objectives/Hypothesis: Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian […] περισσότερα »
Anatomy Pathology 36 Unread articles
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 21 δευτερόλεπταSEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals Valerie Speirs, Bethny Morrisey, Ingunn Holen, Karen Blyth, Phil Carter, Claude Chelala, Louise Jones · Monday, June 06, 2016, 15:55 Tags: Anatomy Pathology – – – – – Der Pathologe Mitteileungen Bundesverband Deutscher Pathologen Saturday, June 04, 2016, 15:23 Tags: Anatomy Pathology – – – – – Der Pathologe Mitteilungen der ÖGPath/IAP Austria Saturday, June 04, 2016, 15:23 Tags: Anatomy Pathology – – … περισσότερα »
Anatomy Pathology 38 Unread articles
Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 21 δευτερόλεπταWell-Differentiated Liposarcoma With Hibernoma-Like Morphology Hallin, M., Schneider, N., Thway, K. · Tuesday, June 07, 2016, 7:54 Well-differentiated liposarcoma (WDL) can show a morphologic spectrum, including lipoma-like, sclerosing and inflammatory subtypes. It does not metastasize but can dedifferentiate, acquiring metastatic potential. Hibernomas are benign neoplasms that show variable differentiation toward brown fat, and can sometimes occur in the abdomen or retroperitoneum. We illustrate a case of retroperitoneal WDL that showed extensive hibernoma-like morphology, with shee… περισσότερα »
Physiology 41 Unread articles
Alexandros G. SfakianakisστοEvolutionary PhysiologyΠριν από 21 δευτερόλεπταMelatonin Inhibits CXCL10 and MMP-1 Production in IL-1β-Stimulated Human Periodontal Ligament Cells Monday, June 06, 2016, 23:55 Abstract Melatonin is a hormone that is mainly secreted by the pineal gland and exhibits a wide spectrum of activities, including antioxidant functions. Melatonin has been detected in gingival crevicular fluid. However, the role of melatonin in periodontal tissue is still uncertain. The aim of this study was to examine the effects of melatonin on inflammatory mediator expression in human periodontal ligament cells (HPDLC). Interleukin (IL)-1β induced CXC c… περισσότερα »
Dental Prosthesis for a Young Cleft Lip and Palate Patient
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταModified PEEK Resin Bonded Fixed Dental Prosthesis for a Young Cleft Lip and Palate Patient: Abstract Objective This clinical report presents the use of a modified poly ether–ether ketone material as an alternative material for the fabrication of resin-bonded fixed dental prosthesis (RBFDP) framework. This new material can be used for patients allergic to metals, maintaining the same high esthetic demand of ceramics, presenting light weightness and a flexibility similar to bone as a distinct advantage over ceramic materials. Conclusions The use of a BioHPP RBFDP framework could be c… περισσότερα »
How the demographic makeup of our community influences speech perception
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταHow the demographic makeup of our community influences speech perception: [image: cm_sbs_024_plain.png] Speech perception is known to be influenced by listeners’ expectations of the speaker. This paper tests whether the demographic makeup of individuals’ communities can influence their perception of foreign sounds by influencing their expectations of the language. Using online experiments with participants from all across the U.S. and matched census data on the proportion of Spanish and other foreign language speakers in participants’ communities, this paper shows that the demograp… περισσότερα »
Gait & Posture : Children with cerebral palsy
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταexperience greater levels of loading at the low back during gait compared to healthy controls” via Gait & Posture Publication date: Available online 6 June 2016 *Source:*Gait & Posture Author(s): D. Kiernan, A. Malone, T. O’Brien, C.K. Simms Excessive trunk motion has been shown to be characteristic of cerebral palsy (CP) gait. However, the associated demands on the lower spine are unknown. This study investigated 3-dimensional reactive forces and moments at the low back in CP children compared to healthy controls. In addition, the impact of functional level of impairment was investi… περισσότερα »
Secondary Acquired Cholesteatoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταPresentation and Tympanoplasty Outcomes.: Objective: Comparing the clinical features and surgical outcomes of patients undergoing tympanoplasty for secondary acquired cholesteatoma (SAC) versus non-complicated tympanic membrane perforation (TMP). Study Design: Retrospective patient review. Setting: Tertiary-care, academic center. Patients: All 41 patients with diagnosis of SAC confirmed at surgery between January 1, 2007 and June 30, 2014, and an age-matched cohort consisting of patients with TMP. Intervention(s): Tympanoplasty using either medial or lateral graft techniques. Ma… περισσότερα »
The Pars Inferior of the Human Inner Ear : Focal Endolymphatic Hydrops
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταFocal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear.: Hypothesis: Endolymphatic hydrops of the human inner ear may be localized focally in the pars inferior of the human inner ear. Background: Endolymphatic hydrops may be found in the human inner ear in patients who in life had suffered from Meniere’s syndrome or a variety of other disorders. The degree of endolymphatic hydrops may differ based on location in the inner ear. Methods: A computer-assisted search of all cases in the collection of the Massachusetts Eye and Ear Infirmary in which endolymphatic … περισσότερα »
The Pars Inferior of the Human Inner Ear
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταFocal Endolymphatic Hydrops as Seen in the Pars Inferior of the Human Inner Ear.: Hypothesis: Endolymphatic hydrops of the human inner ear may be localized focally in the pars inferior of the human inner ear. Background: Endolymphatic hydrops may be found in the human inner ear in patients who in life had suffered from Meniere’s syndrome or a variety of other disorders. The degree of endolymphatic hydrops may differ based on location in the inner ear. Methods: A computer-assisted search of all cases in the collection of the Massachusetts Eye and Ear Infirmary in which endolymphatic … περισσότερα »
Cochlear Implantation in Schwannomas
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταCochlear Implantation in Patients With Intracochlear and Intralabyrinthine Schwannomas.: Objective: Schwannomas may arise primarily within the inner ear, or invade the cochlea or labyrinth from the distal internal auditory canal through transmodiolar or transmacular extension, respectively. To date, very limited data exists regarding cochlear implant (CI) outcomes in this unique population. Study Design: Retrospective case review. Patients: Ten ears (nine patients) with inner ear schwannomas that underwent CI at a single tertiary referral center. Intervention(s): Cochlear implantat… περισσότερα »
Cochlear Histopathology
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταas Observed in Two Patients With a Cochlear Implant Electrode With Positioner.: Hypothesis: This study reports the cochlear histopathology of two patients who during life underwent cochlear implantation with a positioner. Background: A silastic positioner introduced by the Advanced Bionics Corporation in 1999 was designed to position the electrode of the cochlear implant close to the modiolus. The positioner was recalled in the United States in July 2002 because of an apparent higher incidence of bacterial meningitis in patients in whom the positioner had been placed. Methods: Fou… περισσότερα »
Type I Tympanoplasty
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταMeta-Analysis: A Single Variable Analysis.: Objective: To determine which independent variables influencing the efficacy of type I tympanoplasty in adult and pediatric populations. Data Sources: A search of the PubMed database and Cochrane Database of Systematic Reviews using the key words “tympanoplasty OR myringoplasty” from January 1966 to July 2014 was performed. Study Selection: Studies reporting outcomes of myringoplasty or Type I tympanoplasty in primary non-cholesteatomatous chronic tympanic membrane (TM) perforation were included. Data Extraction: Of 4,698 abstracts revie… περισσότερα »
TeleAudiology
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταin the Veterans Health Administration.: Objective: To assess effectiveness of TeleAudiology for hearing aid services. Study Design: Retrospective case-control. Setting: Ambulatory Veterans Health Administration and Community-Based Outpatient Clinics (CBOCs). Patients: 42,697 veterans who received hearing aids from January through September, 2014. Intervention(s): TeleAudiology (TA) and conventional in-person (IP) audiology care. Main Outcome Measure(s): International Outcome Inventory for Hearing Aids (IOI-HA) outcomes data. The IOI-HA is a 7-item survey used to assess hearing a… περισσότερα »
Petroclival Chondrosarcoma
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταA Multicenter Review of 55 Cases and New Staging System.: Objective: To analyze clinical outcomes after treatment of petroclival chondrosarcoma and to propose a novel staging system. Study Design: Retrospective case review, 1995 to 2015. Setting: Multicenter study. Patients: Consecutive patients with histopathologically proven petroclival chondrosarcoma. Intervention(s): Microsurgery, endoscopic endonasal surgery, radiation therapy, observation. Main Outcome Measures: Disease- and treatment-associated morbidity, recurrence, mortality. Results: Fifty-five patients (mean age 42 ye… περισσότερα »
Tissue Preservation Surgical Techniques in Percutaneous Bone Conduction Hearing Devices.
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταA Systematic Review on Complications of Tissue Preservation Surgical Techniques in Percutaneous Bone Conduction Hearing Devices.: Objective: To investigate skin-related postoperative complications from tissue preservation approaches in percutaneous bone conduction device (BCD) implantations. Data Sources: PubMed, Embase, and Cochrane Library. Study Selection: We identified studies on BCDs including the opted surgical technique and derived complications. Retrieved articles were screened using predefined inclusion criteria. Critical appraisal included directness of evidence and risk … περισσότερα »
Botulinum Toxin Treatment of Objective Tinnitus
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταBotulinum Toxin Treatment of Objective Tinnitus Because of Essential Palatal Tremor: A Systematic Review.: Introduction: In contrast to subjective tinnitus, objective tinnitus can be heard by the examiner as well as by the patient. It can be triggered by, among many other etiologies, idiopathic muscular tremor in the soft palate, the essential palatal tremor (EPT). Many treatment modalities have been investigated, of which only Botulinum toxin (BT) injections have shown promising results. Goal: The aim of this study was to evaluate the effect of BT treatment on objective tinnitus du… περισσότερα »
Botulinum Toxin Treatment of Essential Palatal Tremor
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταBotulinum Toxin Treatment of Objective Tinnitus Because of Essential Palatal Tremor: A Systematic Review.: Introduction: In contrast to subjective tinnitus, objective tinnitus can be heard by the examiner as well as by the patient. It can be triggered by, among many other etiologies, idiopathic muscular tremor in the soft palate, the essential palatal tremor (EPT). Many treatment modalities have been investigated, of which only Botulinum toxin (BT) injections have shown promising results. Goal: The aim of this study was to evaluate the effect of BT treatment on objective tinnitus du… περισσότερα »
Ossiculoplasty Outcomes and Complications
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταThe Association of Valsalva Status With Smoking and Its Impact on Ossiculoplasty Outcomes and Complications.: Objectives: To assess the association of a patient’s ability to perform a clinically observed Valsalva maneuver with tobacco smoking and post-ossiculoplasty outcomes. Study Design: Case series with chart review. Setting: Tertiary referral, university-based otology practice. Patients: Adult patients (16-88 years of age) undergoing ossiculoplasty with tympanoplasty or tympanomastoidectomy using cartilage tympanic membrane grafts, retrograde mastoidectomy with canal wall recons… περισσότερα »
Asymmetrical hearing loss accounted for between 2.4% and 22.6% of NIHL cases (L-R difference >15 dB for any frequency 0.5-8 kHz)
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταAsymmetrical Hearing Loss in Cases of Industrial Noise Exposure: A Systematic Review of the Literature.: Objective: Asymmetrical hearing thresholds are common in people claiming compensation for noise-induced hearing loss (NIHL). When present and otherwise unexplained, there is some controversy as to whether such asymmetry can be attributed to occupational noise exposure. In this review, our main objectives were to collate the overall prevalence of this finding in subjects with NIHL, and further, to provide a balanced argument regarding causality. Data Sources: MEDLINE, CINAHL, EMBA… περισσότερα »
Primary Epidermoid Tumors of the Cerebellopontine Angle
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταA Review of 47 Cases.: Objective: To analyze disease presentation, treatment, and clinical course of a consecutive series of patients with primary cerebellopontine angle (CPA) epidermoids. Patients: Forty-seven consecutive patients with previously untreated CPA epidermoids. Intervention(s): Observation and microsurgery. Main Outcome Measures: Disease- and treatment-associated morbidity, recurrence. Results: Forty-seven patients (mean age 39 years; 53% women) were analyzed and the average duration of follow-up was 42 months. The most common presenting symptom was headache (27; 57%)… περισσότερα »
Sitting 3-D CT in Patients With Patulous Eustachian Tube.
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταRelationship Between Clinical Test Results and Morphologic Severity Demonstrated by Sitting 3-D CT in Patients With Patulous Eustachian Tube.: Objective: To investigate the correlation of sitting 3-D computed tomography (CT) scans of the Eustachian tube (ET) with subjective and objective findings in patients with patulous Eustachian tube (PET). Study Design: Retrospective. Setting: Tertiary referral center. Subjects: A retrospective survey of medical records in Sen-En Hospital identified 40 patients and 62 ears with PET between September 2014 and June 2015. Method: Diagnosis of PE… περισσότερα »
mri Compatibility of a New Generation of Active Middle Ear Implant
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταMagnetic Resonance Imaging Compatibility of a New Generation of Active Middle Ear Implant: A Clinically Relevant Temporal Bone Laboratory Study.: Objective: Magnetic resonance imaging (MRI) has become an essential tool of modern medical imaging and disease diagnosis. In November 2014, a new MRI-conditional (up to 1.5 T) generation of an active middle ear implant (AMEI) was released to the market. The aim of the study was to test the MRI compatibility of the new implant system in a clinical-anatomical study. Design: Experimental cadaver head model. Setting: Temporal bone laboratory…. περισσότερα »
Surgical resection of extensive cholesteatoma with medial involvement of the vertical segment of the facial nerve resulted in an unsupported mastoid segment
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταThe Tightrope Facial Nerve-An Unsupported Mastoid Segment After Resection of Recidivistic Cholesteatoma.: Objectives/Hypothesis: Cholesteatomas are epidermal inclusion cysts containing stratified squamous epithelium that arise in the middle ear and mastoid cavities resulting in a persistent inflammatory state. Complications include chronic otorrhea, granulation tissue, and bony erosion. Cholesteatoma growth patterns predict frequent involvement of the Fallopian canal of the facial nerve. Extensive disease may extend to the posterior and middle fossa dura, the otic capsule, the carot… περισσότερα »
Flat-Panel CT Imaging for Individualized Pitch Mapping
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταin Cochlear Implant Users.: Objective: This study aims to identify electrode contact location and to assess frequency deviation between predicted and actual frequency allocation maps in cochlear implant (CI) users. Study Design and Methods: This is a retrospective clinical study. Flat-panel computed tomography (FPCT) scans were collected for 17 CI users. Cochlear length was measured using three-dimensional curved multiplanar reconstruction on high-resolution secondary reconstructions. Each electrode’s percentage of distance from the base of the helicotrema was measured, and a modi… περισσότερα »
Ossiculoplasty
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταThe Impact of Smoking on Ossiculoplasty Outcomes.: Objectives: To assess the impact of tobacco smoking on outcomes after ossiculoplasty. Study Design: Case series with chart review. Setting: Tertiary care center. Patients: Adult patients (16-88 yr of age) undergoing ossiculoplasty with cartilage tympanoplasty. Outcome Measures: Patients were classified as smokers (TOB+) or nonsmokers (TOBN). Comparisons were then made between these two groups with regard to early and late audiometric outcomes, rate of cure of conductive hearing loss, rate of successful graft healing, and incidence … περισσότερα »
ABI in Children with Severe Inner Ear Malformations.
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταLong-term Results of Objective: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. Study Design: Retrospective chart review. Setting: Tertiary referral otolaryngology clinic. Subjects and Methods: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status. The surgeries were performed via retro… περισσότερα »
Auditory Brainstem Implantation in Neurofibromatosis Type II
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπταAuditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.: Objective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after acti… περισσότερα »
Cancer
Alexandros G. SfakianakisστοOtoRhinoLaryngology – Alexandros G. SfakianakisΠριν από 21 δευτερόλεπτα2h The Genomic Data Commons Launches Making genomic and clinical data about cancer accessible to the cancer research community is imperative for our success in applying precision medicine to clinical oncology. The NCI Genomic Data Commons (GDC), released today, brings us a step closer to realizing this goal.By analyzing large sets of shared… 2h Tumor Microenvironment Influences Metabolism of Cancer Cells When we think about tumor heterogeneity, we often imagine variation that originates from genetic and/or epigenetic mechanisms. However, there is increasing evidence that varia… περισσότερα »
Freehand three-dimensional ultrasound to assess semitendinosus muscle morphology
sfakianakismedicsστοORL ALLERGY AESTHETICS ANATOMY Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 31 δευτερόλεπταAbstract In several neurological disorders and muscle injuries, morphological changes of the m. semitendinosus (ST) are presumed to contribute to movement limitations around the knee. Freehand three-dimensional (3D) ultrasound (US), using position tracking of two-dimensional US images to reconstruct a 3D voxel array, can be used to assess muscle morphology in vivo. The aims of […] περισσότερα »
Retraction notice
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 34 δευτερόλεπταfrom Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1U5hJBU περισσότερα »
Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Patricia T Illing | Nicole A Mifsud | Anthony W Purcell from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1VJ2HEj περισσότερα »
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
Alexandros G. SfakianakisστοAllergy Rhinology Immunology AsthmaΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Karlynn E Neu | Carole J Henry Dunand | Patrick C Wilson from Allergy and Immunology via xlomafota13 on Inoreader http://ift.tt/1VJ1wVs περισσότερα »
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Karlynn E Neu | Carole J Henry Dunand | Patrick C Wilson from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ1wVs via IFTTT περισσότερα »
Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Patricia T Illing | Nicole A Mifsud | Anthony W Purcell from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ2HEj via IFTTT περισσότερα »
New concepts in HIV-1 vaccine development
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπτα[image: S09527915.gif] Kathryn E Stephenson | Helen T D’Couto | Dan H Barouch from #ENT via xlomafota13 on Inoreader http://ift.tt/1TSJ47Y via IFTTT περισσότερα »
Auditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπταObjective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after activation. Environmental sounds could be differentiated by six (75%) patients after 6 months of ABI use (mean score… περισσότερα »
Long-term Results of ABI in Children with Severe Inner Ear Malformations.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπταObjective: To report the long-term outcomes of children who received auditory brainstem implant (ABI) because of severe inner ear malformations. Study Design: Retrospective chart review. Setting: Tertiary referral otolaryngology clinic. Subjects and Methods: Between July 2006 and October 2014, 60 children received ABI at Hacettepe University. Preoperative work up included otolaryngologic examination, audiological assessment, radiological evaluation together with assessment of language development and psychological status. The surgeries were performed via retrosigmoid approach with a… περισσότερα »
The Impact of Smoking on Ossiculoplasty Outcomes.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπταObjectives: To assess the impact of tobacco smoking on outcomes after ossiculoplasty. Study Design: Case series with chart review. Setting: Tertiary care center. Patients: Adult patients (16-88 yr of age) undergoing ossiculoplasty with cartilage tympanoplasty. Outcome Measures: Patients were classified as smokers (TOB+) or nonsmokers (TOBN). Comparisons were then made between these two groups with regard to early and late audiometric outcomes, rate of cure of conductive hearing loss, rate of successful graft healing, and incidence of complications after surgery. Results: There was n… περισσότερα »
Flat-Panel CT Imaging for Individualized Pitch Mapping in Cochlear Implant Users.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 34 δευτερόλεπταObjective: This study aims to identify electrode contact location and to assess frequency deviation between predicted and actual frequency allocation maps in cochlear implant (CI) users. Study Design and Methods: This is a retrospective clinical study. Flat-panel computed tomography (FPCT) scans were collected for 17 CI users. Cochlear length was measured using three-dimensional curved multiplanar reconstruction on high-resolution secondary reconstructions. Each electrode’s percentage of distance from the base of the helicotrema was measured, and a modified Greenwood’s function was … περισσότερα »
Radioactive Iodine Treatment Is Associated with Improved Survival for Patients with Hürthle Cell Carcinoma
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1U5cmma via IFTTT περισσότερα »
Thyroid Cancer–Specific Quality of Life and Health-Related Quality of Life in Young Adult Thyroid Cancer Survivors
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1tdDzdT via IFTTT περισσότερα »
Prognostic Significance of TERT Promoter Mutations in Papillary Thyroid Carcinomas in a BRAFV600E Mutation–Prevalent Population
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταThyroid , Vol. 0, No. 0. from #ENT via xlomafota13 on Inoreader http://ift.tt/1raND5B via IFTTT περισσότερα »
A chilling reminder: Pediatric facial trauma from recreational winter activities
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταPublication date: August 2016 *Source:*International Journal of Pediatric Otorhinolaryngology, Volume 87 Author(s): Peter F. Svider, Michael Bobian, Houmehr Hojjat, Anthony Sheyn, Giancarlo Zuliani, Jean Anderson Eloy, Adam J. Folbe BackgroundWinter activities offer children and adolescents an outdoor recreational opportunity during the coldest months. Our objectives were to estimate the national incidence of facial injury associated with recreational winter activities. Furthermore, we analyze demographic trends and clinical characteristics of patients presenting to emergency depart… περισσότερα »
Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα[image: S09527915.gif] Patricia T Illing | Nicole A Mifsud | Anthony W Purcell from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ2HEj via IFTTT περισσότερα »
Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα[image: S09527915.gif] Karlynn E Neu | Carole J Henry Dunand | Patrick C Wilson from #ENT via xlomafota13 on Inoreader http://ift.tt/1VJ1wVs via IFTTT περισσότερα »
New concepts in HIV-1 vaccine development
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπτα[image: S09527915.gif] Kathryn E Stephenson | Helen T D’Couto | Dan H Barouch from #ENT via xlomafota13 on Inoreader http://ift.tt/1TSJ47Y via IFTTT περισσότερα »
Auditory Brainstem Implantation in Chinese Patients With Neurofibromatosis Type II: The Hong Kong Experience.
Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 44 δευτερόλεπταObjective: To describe our experience and outcomes of auditory brainstem implantation (ABI) in Chinese patients with Neurofibromatosis Type II (NF2). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients with NF2 who received ABIs. Results: Between 1997 and 2014, eight patients with NF2 received 9 ABIs after translabyrinthine removal of their vestibular schwannomas. One patient did not have auditory response using the ABI after activation. Environmental sounds could be differentiated by six (75%) patients after 6 months of ABI use (mean score… περισσότερα »
The association of Red cell distribution width and in-hospital mortality in older adults admitted to the emergency department
Αλέξανδρος ΣφακιανάκηςστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώραThe objective of the study was to test the hypothesis that elevated red cell distribution width (RDW) at admission increases the risk of mortality in older patients admitted to the emergency department (ED). from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1Xz7070 περισσότερα »
The association of Red cell distribution width and in-hospital mortality in older adults admitted to the emergency department
Alexandros G. SfakianakisστοEmergency Medicine by Alexandros G. SfakianakisΠριν από 1 ώραThe objective of the study was to test the hypothesis that elevated red cell distribution width (RDW) at admission increases the risk of mortality in older patients admitted to the emergency department (ED). from Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/1Xz7070 via IFTTT περισσότερα »
Rhizobium leguminosarum symbiovar trifolii, Ensifer numidicus, and Mesorhizobium amorphae symbiovar ciceri (or Mesorhizobium loti) are new endosymbiotic bacteria of Lens culinaris Medik
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα142 rhizobial bacteria were isolated from root nodules of Lens culinaris Medik endemic to Tunisia and they belonged to the species Rhizobium leguminosarum and for the first time to Ensifer and Mesorhizobium, genera never previously described as microsymbionts of lentil. Phenotypically, our results indicate that Lens culinaris Medik strains showed heterogenic responses to the different […] περισσότερα »
Methane release from sediment seeps to the atmosphere is counteracted by highly active Methylococcaceae in the water column of deep oligotrophic Lake Constance
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραMethane emissions from freshwater environments contribute substantially to global warming but are under strong control of aerobic methane-oxidizing bacteria. Recently discovered methane seeps (pockmarks) in freshwater lake sediments have the potential to bypass this control by their strong outgasing activity. Whether this is counteracted by pelagic methanotrophs is not well understood yet. We used a […] περισσότερα »
Subalpine conifers in two different geographic locations host highly similar foliar bacterial endophyte communities.
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραPines in the subalpine environment at Niwot Ridge, CO have been found to host communities of acetic acid bacteria (AAB) within their needles. The significance and ubiquity of this pattern is not known, but recent evidence of nitrogen (N)-fixing activity inside Pinus flexilis (limber pine) foliage calls for a better understanding of the processes that […] περισσότερα »
Benthic protists: the under-charted majority
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραMarine protist diversity inventories have largely focused on planktonic environments, while benthic protists have received relatively little attention. We therefore hypothesize that current diversity surveys have only skimmed the surface of protist diversity in marine sediments, which may harbour greater diversity than planktonic environments. We tested this by analyzing sequences of the hypervariable V4 18S […] περισσότερα »
Reply: Perifascicular necrosis in anti-synthetase syndrome beyond anti-Jo-1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραfrom #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1Yc3VIR via IFTTT περισσότερα »
Perifascicular necrosis in anti-synthetase syndrome beyond anti-Jo-1
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραfrom #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1t3VVxe via IFTTT περισσότερα »
Aberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραMutations in brain isoforms of voltage-gated sodium channels have been identified in patients with distinct epileptic phenotypes. Clinically, these patients often do not respond well to classic anti-epileptics and many remain refractory to treatment. Exogenous as well as endogenous cannabinoids have been shown to target voltage-gated sodium channels and cannabidiol has recently received attention for […] περισσότερα »
Distinct Oral Neutrophil Subsets Define Health and Periodontal Disease States
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραNeutrophils exit the vasculature and swarm to sites of inflammation and infection. However, these cells are abundant in the healthy, inflammation-free human oral environment, suggesting a unique immune surveillance role within the periodontium. We hypothesize that neutrophils in the healthy oral cavity occur in an intermediary parainflammatory state that allows them to interact with and […] περισσότερα »
Well-Differentiated Liposarcoma With Hibernoma-Like Morphology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραWell-differentiated liposarcoma (WDL) can show a morphologic spectrum, including lipoma-like, sclerosing and inflammatory subtypes. It does not metastasize but can dedifferentiate, acquiring metastatic potential. Hibernomas are benign neoplasms that show variable differentiation toward brown fat, and can sometimes occur in the abdomen or retroperitoneum. We illustrate a case of retroperitoneal WDL that showed extensive hibernoma-like […] περισσότερα »
Evidence for a Notch1-mediated transition during olfactory ensheathing cell development
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώραAbstract Olfactory ensheathing cells (OECs) are a unique glial population found in both the peripheral and central nervous system: they ensheath bundles of unmyelinated olfactory axons from their peripheral origin in the olfactory epithelium to their central synaptic targets in the glomerular layer of the olfactory bulb. Like all other peripheral glia (Schwann cells, satellite […] περισσότερα »
Editorial Board
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orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώραfrom #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Yc52YS via IFTTT περισσότερα »
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«Music Therapy Helped Me Get Back Doing»: Perspectives of Music Therapy Participants in Mental Health Services
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώραBackground: Mental health service development internationally is increasingly informed by the collaborative ethos of recovery. Service user evaluation of experiences within music therapy programs allows new phenomena about participation in services to be revealed that might otherwise remain unnoticed. Objective: The aim of this study was to demonstrate how asking service users about their experience… Continue reading «Music Therapy Helped Me Get Back Doing»: Perspectives of Music Therapy Participants in Mental Health Services περισσότερα »
Table of Contents
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώραfrom #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1t3X5J5 via IFTTT περισσότερα »
Vocal Music Therapy for Chronic Pain Management in Inner-City African Americans: A Mixed Methods Feasibility Study
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώραBackground: To date, research on music for pain management has focused primarily on listening to prerecorded music for acute pain. Research is needed on the impact of active music therapy interventions on chronic pain management. Objective: The aim of this mixed methods research study was to determine feasibility and estimates of effect of vocal music… Continue reading Vocal Music Therapy for Chronic Pain Management in Inner-City African Americans: A Mixed Methods Feasibility Study περισσότερα »
Obscure Retropharyngeal Mucocutaneous Masses Associated With Acoustic Neurofibromatosis: A Source of Difficult Airway Management.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώραNo abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1t3WkzR via IFTTT περισσότερα »
The Power of Raw Data.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώραNo abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Yc3JJu via IFTTT περισσότερα »
Cerebral Oxygenation Under General Anesthesia Can Be Safely Preserved in Patients in Prone Position: A Prospective Observational Study.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώραBackground: The effects of prone position (PP) on cerebral tissue metabolism are not well known. The aim of this investigation was to evaluate regional cerebral oxygen desaturation in patients undergoing lumbar spine surgery in PP during routine anesthesia management. Materials and Methods: Between July 2013 and October 2013, 50 consecutive patients undergoing lumbar spine surgery… Continue reading Cerebral Oxygenation Under General Anesthesia Can Be Safely Preserved in Patients in Prone Position: A Prospective Observational Study. περισσότερα »
Anesthetic Challenges in the Management of Distal Posterior Cerebral Artery Aneurysm for Surgical Clipping: A Report of 2 Cases.
orlsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.AlexandrosΠριν από 1 ώραNo abstract available from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Yc4pOU via IFTTT περισσότερα »
Using the Swiss ball versus peanut ball to assess the back extensors endurance among healthy collegiate physical therapy students at Taibah University
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρες2016-06-06T19-38-22Z *Source:* International Journal of Therapies and Rehabilitation Research Tarek Mohamed El-gohary; Osama A. Khaled. Spinal extensors endurance is a vital and fundamental pillar for the general endurance. Good endurance helps in injury prevention, and improves efficiency in all physical activities across different ages. Endurance testing of back extensors has been extensively examined in literature but there are many criticisms to the suitability and the practicality of the commonly used tests. The purpose of this study was to compare the endurance ability of the tr… περισσότερα »
Distribution of IL28B Polymorphism in a Cohort of Italians and Immigrants with HCV Infection: Association with Viraemia, Stage of Fibrosis and Response to Treatment
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρεςAbstract Aims of the study are to investigate, in a cohort of patients affected by HCV chronic hepatitis with genotypes 1 and 4, the prevalence of interleukin 28B (IL28B) genotypes, the possible association between IL28B polymorphism and severity of liver damage, the role of IL28B CC as a predictor of outcome. 365 patients with HCV infection were observed between 2013 and 2014. Demographic, virological, biochemical, and genetic characteristics of each patient were investigated. Liver fibrosis was assessed by transient elastometry. Mean age of the patients (72.9 % males, 27.1 % femal… περισσότερα »
Indigenous Adolescents’ Suicidal Behaviors and Risk Factors: Evidence from the National Youth Risk Behavior Survey
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρεςAbstract The study sought to examine indigenous adolescents’ suicidal behaviors and risk factors in a nationally representative sample and explore potential causes of disparities. The study analyzed the 1991–2013 Youth Risk Behavior Survey National Combined Datasets. Suicidal behavior outcomes included suicide consideration, planning, and attempts during the past 12 months. Logit regressions were used to estimate the effects of potential suicide risk factors on these suicidal behaviors. The results showed that a high percentage of indigenous adolescents exhibited suicidal behaviors … περισσότερα »
Ethnic Disparities in Blood Pressure: A Population-based Study
Alexandros G. SfakianakisστοΝοσολογίαΠριν από 2 ώρεςAbstract Taiwan’s indigenous population exhibits a higher mortality of cardiovascular disease, but current research has not reported any associations among ethnicities on the blood pressure (BP). We randomly selected representative samples in this population-based study. We measured height, weight, hip and waist circumferences, and blood pressure in a screening survey. Systolic BP and diastolic BP were significantly higher in the indigenous population. Among women, prevalence rates of DBP > 90 mmHg among indigenes (32.9 %) were significantly high than those in Han Chinese (17.4 %)…. περισσότερα »
Supernumerary renal vessels: analysis of frequency and configuration in 996 computed tomography studies
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρεςBackground: Number, course and division pattern of renal vessels is highly variable. Variant renal vasculature is of high interest in nephrectomy for the renal transplantations, both in deceased and living donors. The purpose of the study was to analyse the frequency of supernumerary renal vessels in a large cohort of patients undergoing the multiphase abdominopelvic […] περισσότερα »
Cone beam computed tomography investigation of the antral artery anastomosis in a population of Central Italy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρεςBackground: The arterial vascular supply of maxillary sinus has to be considered in all the surgical procedures where it is involved. In particular, the intraosseous anastomosis between the posterior superior alveolar artery and the infraorbital artery branches in the bony canal can be tricky to a not well aware clinician. The aim of this study […] περισσότερα »
Morphological characteristics of the sinus node on postmortem tissue
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρεςThe sinus node is an intensively researched structure in terms of anatomical, histological, electrophysiological, molecular and genetic approach. For postmortem diagnosis it is still difficult to investigate due to a still reduced accessibility. In this study we tried and succeed to apply molecular biology techniques on postmortem tissues in order to widen the range of […] περισσότερα »
A cephalic vein drained into one of the double axillary veins through the pectoralis major muscle
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρεςAlthough the cephalic vein follows a fairly consistent course, numerous variants have been reported. We found a rare anatomical presentation of the cephalic vein in a 43-year-old Korean male cadaver. The cephalic vein had anastomosed with the basilic vein and brachial vein at the level of the elbow, perforated the pectoralis major muscle between the […] περισσότερα »
Porcine liver vascular bed in Biodur E20 corrosion casts
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρεςBackground: Pigs are frequently used as animal models in experimental medicine. To identify processes of vascular development or regression, vascular elements must be recognised and quantified in a three-dimensional (3D) arrangement. Vascular corrosion casts enable the creation of 3D replicas of vascular trees. The aim of our study was to identify suitable casting media and […] περισσότερα »
Lymphatic vessels around the uterus: D2-40 (podoplandin) immunohistochemistry using elderly cadavers
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρεςUsing D2-40 immunohistochemistry, we examined the morphology of lymphatic vessels (LVs) in, along and around the uterus of 10 donated female cadavers (mean age, 85 years). All these women had 1 or 2 children with vaginal delivery, but the other obstetrics information was unknown. When compared with the bladder, vagina and the subperitoneal tissue, the […] περισσότερα »
Fine structure of the dorsal lingual epithelium in Tarentola annularis and Crocodylus niloticus
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 2 ώρεςThe present study examined the morphological features, histological and histochemical aspect of the tongue of two reptilian species, Tarentola annularis (family: Gekkonidae) and Crocodylus niloticus (family: Crocodylidea), with different habitats, feeding patterns and behaviours, by light and scanning electron microscope. It was observed, that the bifurcation of the tongue was more visible in Tarentola annularis. […]
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Cancer
Today, 7 Ιουνίου 2016,
7 hours ago | Alexandros Sfakianakis
2h
The Genomic Data Commons Launches
Making genomic and clinical data about cancer accessible to the cancer research community is imperative for our success in applying precision medicine to clinical oncology. The NCI Genomic Data Commons (GDC), released today, brings us a step closer to realizing this goal.By analyzing large sets of shared…
2h
Tumor Microenvironment Influences Metabolism of Cancer Cells
When we think about tumor heterogeneity, we often imagine variation that originates from genetic and/or epigenetic mechanisms. However, there is increasing evidence that variation exists at the level of cellular metabolism and that this intratumoral heterogeneity could be important to tumor progression….
2h
Patient-Derived Antibody Appears to Selectively Target Tumor Cells, Spur Immune Attack
Researchers have developed an antibody, derived from patients with early-stage lung cancer, that enlists the immune system to destroy cancer cells.The antibody killed tumor cells in cell lines of several different cancer types and slowed tumor growth in mouse models of brain and lung cancer without obvious…
2h
Erratum to: Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study
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2h
Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment
Abstract Background The 3-dimensional (3D) microenvironment of breast carcinomas is characterized by profoundly altered pH homeostasis, reflecting increased metabolic acid production and a confined extracellular space characterized…
5h
Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells
Abstract Adoptive cell therapy (ACT) employing ex vivo-generated tumor antigen-specific CD8+ T cells shows tumor efficacy when the transferred cells possess both effector and memory functions. New strategies based on understanding of mechanisms that balance CD8+ T cell differentiation…
5h
Immunotherapy after hematopoietic stem cell transplantation using umbilical cord blood-derived products
Abstract Umbilical cord blood (UCB) is being increasingly used as a source of hematopoietic stem cells (HSC) for transplantation. UCB transplantation (UCBT) has some advantages such as less stringent HLA-matching requirements, fast availability of the graft and reduced incidence and…
5h
Immunoglobulin G4 (IgG4)-positive plasma cell infiltration is associated with the clinicopathologic traits and prognosis of pancreatic cancer after curative resection
Abstract Interactions between pancreatic cancer cells and inflammatory cells play crucial roles in the biological behavior of pancreatic cancer. Abundant infiltration of immunoglobulin G4 (IgG4)-positive plasma cells in the pancreas is the most significant feature of autoimmune pancreatitis;…
5h
Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma
Odontogenic myxoma (OM) is a rare mesenchymal tumour arising in the jaws. The origin and pathogenesis of OM is poorly understood. The aim of this study was to characterize OM by immunolocalization of certain antigens in the tumour that are relevant for cellular differentiation, migration and maintenance….
5h
Imaging of Gastrointestinal Stromal Tumors: From Diagnosis to Evaluation of Therapeutic Response
Once considered an obscure tumor entity with poor prognosis, gastrointestinal stromal tumors (GISTs) are nowadays recognized as the most common mesenchymal tumors of the alimentary tract. GISTs differ from other mesenchymal neoplasms at pathology since 90% of them exhibit strong immunohistochemical staining…
5h
Birinapant (TL32711) Improves Responses to GEM/AZD7762 Combination Therapy in Triple-negative Breast Cancer Cell Lines
Background: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer currently lacking targeted therapies. Our previous work demonstrated a therapeutic synergism with gemcitabine (GEM) and the CHK1 inhibitor (AZD7762) combination treatment in a TNBC cell line. We hypothesized that…
5h
Intestinal Polyposis Syndromes
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5h
Endometrial Adenocarcinoma: Analysis of Circulating Tumour Cells by RT-qPCR
Background: Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized,…
5h
Decreased Expression of Retinoid X Receptors During Human and Azoxymethane-induced Colorectal Carcinogenesis in the Rat
Background/Aim: The family of retinoid X receptors (RXRs) including RXRα, β and , is involved in regulating cell proliferation, differentiation, apoptosis and development. Materials and Methods: In order to characterize the role of RXRs during colorectal carcinogenesis, the expression of RXRs in human…
5h
The Contribution of Dental Implants to Functional Artificial Restoration After Treatment of Oral Cancer
Background/Aim: The aim of this study was to evaluate dental implants with regard to artificial restoration of oral function and quality of life in patients with oral cancer. Patients and Methods: We examined 134 implants in 41 patients who had undergone jawbone resection as treatment for oral cancer….
5h
Induction of Apoptosis by Functionalized Fullerene-based Sonodynamic Therapy in HL-60 cells
Ultrasound has been widely utilized for medical diagnosis and therapy due to its ability to penetrate deep-seated tissue with less attenuation of energy and minimal undesirable side-effects. Functionalized fullerenes, such as polyhydroxy fullerene (PHF), have attracted particular attention due to their…
5h
siRNA Targeting of MDR1 Reverses Multidrug Resistance in a Nude Mouse Model of Doxorubicin-resistant Human Hepatocellular Carcinoma
Aim: To investigate the effects of vector-based small interfering RNA (siRNA) targeting MDR1 on the reversal of multidrug resistance in a mouse model of doxorubicin (DOX)-resistant human hepatocellular carcinoma. Materials and Methods: Three siRNAs plasmid vectors (MDR1 siRNA1, MDR1 siRNA2 and MDR1 siRNA3)…
5h
Expansive Extracranial Growth of Intracranial Meningioma in Neurofibromatosis Type 2
The purpose of this report is to detail three rare cases of neurofibromatosis type 2 (NF2) with symptomatic extracranial extension of intracranial meningioma. We present ocular findings, imaging techniques applied, pathological findings of the space-occupying lesions, and therapy. One of these patients,…
5h
Immunology of the Skin. Basic and Clinical Sciences in Skin Immune Responses
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5h
Management of Metastatic Bone Disease Algorithms for Diagnostics and Treatment
Background: Bone is a frequent site of metastases in advanced cancer and is associated with significant skeletal morbidity. Current treatment options are aimed at preserving and improving functional independence and quality of life. Materials and Methods: A review of current literature focusing on diagnostic…
5h
Heterogeneity of Vascular Endothelial Growth Factor Receptors 1, 2, 3 in Primary Human Colorectal Carcinoma
Background: The vascular endothelial growth factor (VEGF) pathway plays an important role in growth and progression of human cancer, including colorectal carcinomas (CRC). The key mediators of VEGF signaling are VEGFR1, VEGFR2, and VEGFR3, part of a family of related receptor tyrosine kinases. The relative…
5h
Identification of ESE1 as a {beta}-Catenin Binding Protein
Background/Aim: β-Catenin regulates cell-cell adhesion and gene transcription and acts as a master switch that controls proliferation in several types of cancer. ESE1 is an epithelium-restricted transcription factor and its multiple domain structure predicts its interaction with other proteins with diverse…
5h
Depth of Hepatic Infiltration and Lymph Node Swelling as Factors for Considering Surgery for T2-4 Gallbladder Carcinoma Patients
Background/Aim: The aim of the present study was to clarify if the degree of hepatic infiltration and lymph node swelling of gallbladder carcinoma (GBC) should be held as deciding factors for T2-4 GBC patients to undergo surgery. Patients and Methods: Fifty consecutive patients with T2-4 GBC who underwent…
5h
Activation of the PERK-eIF2{alpha} Pathway Is Associated with Tumor-infiltrating Lymphocytes in HER2-Positive Breast Cancer
Background: We evaluated endoplasmic reticulum stress and unfolded protein response (UPR) activation, as possible mechanisms for influx of tumor infiltrating lymphocytes (TILs), and the correlation between UPR activation and mammalian target of rapamycin (mTOR) pathway activation. Materials and Methods:…
5h
Immunohistochemical Evaluation of the Role of p53 Mutation in Cervical Cancer: Ser-20 p53-Mutant Correlates with Better Prognosis
Background: Cervical cancer is driven by human papillomavirus virus-specific oncoprotein E6. E6 interacts with E3 ubiquitin-protein ligase, resulting in the proteolysis of p53 protein. The aim of this study was to analyze one TP53 mutation in patients with cervical cancer and to correlate it to prognosis….
5h
Chronomodulated oxaliplatin plus Capecitabine (XELOX) as a first line chemotherapy in metastatic colorectal cancer: A Phase II Brunch regimen study
Abstract Purpose The aim of this study was to evaluate safety and toxicity of chronomodulated capecitabine administered in the morning and at noon according to a specific time schedule (Brunch Regimen: Breakfast and Lunch) as a part of…
5h
[Comment] Lung cancer risk in new pulmonary nodules: implications for CT screening and nodule management
The Dutch-Belgian Randomised Lung Cancer Screen Trial (NELSON)1 of low-dose CT versus usual care has provided unique evidence about the risk of lung cancer in pulmonary nodules according to semiautomated measurement of the volume of a nodule, calculated diameter, and growth rate expressed as volume doubling…
5h
[Articles] Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT: analysis of data from the randomised, controlled NELSON trial
Our study shows that new solid nodules are detected at each screening round in 5–7% of individuals who undergo screening for lung cancer with low-dose CT. These new nodules have a high probability of malignancy even at a small size. These findings should be considered in future screening guidelines,…
6h
Chronomodulated oxaliplatin plus Capecitabine (XELOX) as a first line chemotherapy in metastatic colorectal cancer: A Phase II Brunch regimen study
Abstract Purpose The aim of this study was to evaluate safety and toxicity of chronomodulated capecitabine administered in the morning and at noon according to a specific time schedule (Brunch Regimen: Breakfast and Lunch) as a part of…
6h
Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a
Glioma is one of the most common and aggressive primary malignant tumor in the brain. Accumulating evidences indicated that aberrantly expressed non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNA… from Cancer via xlomafota13 on Inoreader http://ift.tt/1UuWcQ6 via IFTTT
6h
Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool
Abstract Background Colorectal cancers (CRC) are associated with perturbations in cellular amino acids, nucleotides, pentose-phosphate pathway carbohydrates, and glycolytic, gluconeogenic, and tricarboxylic acid intermediates. A non-targeted…
7h
Reducing Anesthesia and Health Care Cost through Utilization of Child Life Specialists in Pediatric Radiation Oncology
Publication date: Available online 5 June 2016Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Michael T. Scott, Kimberly E. Todd, Heather Oakley, Julie Bradley, Ronny Rotondo, Christopher G. Morris, Stuart Klein, Nancy P. Mendenhall, Daniel J. IndelicatoPurposeDuring…
7h
Rapidly Progressing Primary Extrahepatic Bile Duct Signet-Ring Cell Carcinoma in a Caucasian Woman
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9h
Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system
Abstract Answer questions and earn CME/CNE In this report, a team of surgical pathologists has provided a review of intraepithelial neoplasia in a host of (but not all) anatomic sites of interest to colleagues in various medical specialties, namely, uterine cervix, ovary, breast, lung, head and neck,…
9h
Military Metaphors and the Consequences of the Language of Cancer
Publication date: Available online 6 June 2016Source:Practical Radiation Oncology Author(s): Edward C. Halperin from Cancer via xlomafota13 on Inoreader http://ift.tt/1Xy0fCj via IFTTT
10h
Associations between metabolic syndrome, breast cancer recurrence, and the 21-gene recurrence score assay
Abstract The 21-gene recurrence score (RS) assay is prognostic in estrogen receptor-positive (HR+), HER2-negative, node-negative breast cancer (BC). The interaction between RS and host factors including metabolic syndrome (MS) is unclear. MS conditions such as obesity have been associated…
10h
Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: a population-based analysis
Abstract Few contemporary data are available that compare incidence and survival of metastatic breast cancer between ductal and lobular carcinomas. Using the Surveillance, Epidemiology, and End Results-9 registries, we identified 10,639 patients with de novo metastatic breast cancer…
10h
[Articles] Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: a randomised, open-label, phase 3 trial
Nivolumab was associated with HRQoL improvement compared with everolimus in previously treated patients with advanced renal cell carcinoma. from Cancer via xlomafota13 on Inoreader http://ift.tt/1PeNap2 via IFTTT
10h
Long-term cardiovascular outcomes and overall survival of early-stage breast cancer patients with early discontinuation of trastuzumab: a population-based study
Abstract We critically examined long-term cardiovascular (CV) outcomes and overall survival (OS) of breast cancer (BC) patients who had cardiotoxicity during adjuvant trastuzumab treatment requiring discontinuation in a population-based sample. This was a retrospective cohort of early-stage…
10h
[Comment] Improved quality of life is the way to longer life
In The Lancet Oncology, David Cella and colleagues1 report the quality-of-life results from the previously published Checkmate 025 trial.2 The original study, which included patients with advanced renal cell carcinoma previously treated with antiangiogenic therapies, showed that nivolumab was superior…
10h
Risk of biochemical recurrence and timing of radiotherapy in pT3a N0 prostate cancer with positive surgical margin
Abstract Background Despite improved biochemical recurrence-free survival rates by the use of immediate adjuvant radiotherapy (RT) in patients with locally advanced prostate cancer, disagreement about the need and timing of RT remains….
10h
Protonentherapie bei Kindern mit Medulloblastom bei akzeptablen Nebenwirkungen ähnlich erfolgreich wie Photonentherapie
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10h
Neoadjuvant chemoradiotherapy of rectal carcinoma
Abstract Background The link between the blood count and a systemic inflammatory response (SIR) is indisputable and well described. Pretreatment hematological parameters may predict the overall clinical outcomes in many types of cancer….
10h
Capacitabine und Oxaliplatin (XelOx) im Vergleich zu Fluorouracil/Folinsäure als adjuvante Therapie bei Kolonkarzinomen im Stadium III: Ergebnisse der kontrollierten randomisierten Phase III-Studie NO16968
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11h
OLA1 gene sequencing in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer
Abstract Background Of individuals with suspected hereditary breast and ovarian cancer (HBOC), approximately 30–70 % do not harbor mutations in either BRCA1 or BRCA2 gene, which suggests that these individuals have other genetic or epigenetic…
12h
A Systematic Review: Childhood Cancer Survivors and Gastrointestinal Cancer
Publication date: Available online 6 June 2016Source:Cancer Treatment Reviews Author(s): Isabel Griffin, Purnima Madhivanan from Cancer via xlomafota13 on Inoreader http://ift.tt/1t2a6D3 via IFTTT
13h
Serum microRNA panels as potential biomarkers for early detection of hepatocellular carcinoma on top of HCV infection
Abstract The identification of new high-sensitivity and high-specificity markers for hepatocellular carcinoma (HCC) is essential. We aimed at identifying serum microRNAs (miRNAs) as potential biomarkers for early detection of HCC on top hepatitis C virus (HCV) infection. We investigated…
14h
[Articles] Dabrafenib plus trametinib in patients with previously treated -mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial
Dabrafenib plus trametinib could represent a new targeted therapy with robust antitumour activity and a manageable safety profile in patients with BRAFV600E-mutant NSCLC. from Cancer via xlomafota13 on Inoreader http://ift.tt/1PesygF via IFTTT
14h
[Comment] Combined BRAF and MEK inhibition in -mutant NSCLC
In the past two decades many of the molecular drivers of non-small-cell lung cancer (NSCLC) have been elucidated and therapies targeting these changes have offered new hope and improved survival for patients. In NSCLC, these treatments have been honed in the treatment of EGFR-mutated and ALK-mutated…
14h
PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions
PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions Oncogenesis 5, e232 (June 2016). doi:10.1038/oncsis.2016.41 Authors: X Wang, G Wang, Y Shi, L Sun, R Gorczynski, Y-J Li, Z Xu & D E Spaner from Cancer via xlomafota13 on Inoreader…
14h
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway Oncogenesis 5, e231 (June 2016). doi:10.1038/oncsis.2016.39 Authors: C L Duran, D W Lee, J-U Jung, S Ravi, C B Pogue, L G Toussaint, K J Bayless & R Sitcheran…
14h
Pharmacokinetic profiles of significant adverse events with crizotinib in Japanese patients with ABCB1 polymorphism
Summary Crizotinib is a standard treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC). We conducted this study to investigate the pharmacokinetics of crizotinib and clinical and pharmacogenomic factors that may increase the risk of adverse events (AEs). We defined clinically significant…
14h
HIF-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model
Abstract Pancreatic cancer is one of the most lethal digestive system cancers with a 5-year survival rate of 4%–7%. Despite extensive efforts, recent chemotherapeutic regimens have provided only limited benefits to pancreatic cancer patients. Gemcitabine and TS-1, the current standard-of-care chemotherapeutic…
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The Genomic Data Commons Launches
Making genomic and clinical data about cancer accessible to the cancer research community is imperative for our success in applying precision medicine to clinical oncology. The NCI Genomic Data Commons (GDC), released today, brings us a step closer to realizing this goal.By analyzing large sets of shared…
2h
Tumor Microenvironment Influences Metabolism of Cancer Cells
When we think about tumor heterogeneity, we often imagine variation that originates from genetic and/or epigenetic mechanisms. However, there is increasing evidence that variation exists at the level of cellular metabolism and that this intratumoral heterogeneity could be important to tumor progression….
2h
Patient-Derived Antibody Appears to Selectively Target Tumor Cells, Spur Immune Attack
Researchers have developed an antibody, derived from patients with early-stage lung cancer, that enlists the immune system to destroy cancer cells.The antibody killed tumor cells in cell lines of several different cancer types and slowed tumor growth in mouse models of brain and lung cancer without obvious…
2h
Erratum to: Superselective intraarterial cerebral infusion of cetuximab after osmotic blood/brain barrier disruption for recurrent malignant glioma: phase I study
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2h
Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment
Abstract Background The 3-dimensional (3D) microenvironment of breast carcinomas is characterized by profoundly altered pH homeostasis, reflecting increased metabolic acid production and a confined extracellular space characterized…
5h
Uncoupling protein 2 regulates metabolic reprogramming and fate of antigen-stimulated CD8+ T cells
Abstract Adoptive cell therapy (ACT) employing ex vivo-generated tumor antigen-specific CD8+ T cells shows tumor efficacy when the transferred cells possess both effector and memory functions. New strategies based on understanding of mechanisms that balance CD8+ T cell differentiation…
5h
Immunotherapy after hematopoietic stem cell transplantation using umbilical cord blood-derived products
Abstract Umbilical cord blood (UCB) is being increasingly used as a source of hematopoietic stem cells (HSC) for transplantation. UCB transplantation (UCBT) has some advantages such as less stringent HLA-matching requirements, fast availability of the graft and reduced incidence and…
5h
Immunoglobulin G4 (IgG4)-positive plasma cell infiltration is associated with the clinicopathologic traits and prognosis of pancreatic cancer after curative resection
Abstract Interactions between pancreatic cancer cells and inflammatory cells play crucial roles in the biological behavior of pancreatic cancer. Abundant infiltration of immunoglobulin G4 (IgG4)-positive plasma cells in the pancreas is the most significant feature of autoimmune pancreatitis;…
5h
Expression of the Insulin-like Growth Factor-1 Receptor in Odontogenic Myxoma
Odontogenic myxoma (OM) is a rare mesenchymal tumour arising in the jaws. The origin and pathogenesis of OM is poorly understood. The aim of this study was to characterize OM by immunolocalization of certain antigens in the tumour that are relevant for cellular differentiation, migration and maintenance….
5h
Imaging of Gastrointestinal Stromal Tumors: From Diagnosis to Evaluation of Therapeutic Response
Once considered an obscure tumor entity with poor prognosis, gastrointestinal stromal tumors (GISTs) are nowadays recognized as the most common mesenchymal tumors of the alimentary tract. GISTs differ from other mesenchymal neoplasms at pathology since 90% of them exhibit strong immunohistochemical staining…
5h
Birinapant (TL32711) Improves Responses to GEM/AZD7762 Combination Therapy in Triple-negative Breast Cancer Cell Lines
Background: Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer currently lacking targeted therapies. Our previous work demonstrated a therapeutic synergism with gemcitabine (GEM) and the CHK1 inhibitor (AZD7762) combination treatment in a TNBC cell line. We hypothesized that…
5h
Intestinal Polyposis Syndromes
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5h
Endometrial Adenocarcinoma: Analysis of Circulating Tumour Cells by RT-qPCR
Background: Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized,…
5h
Decreased Expression of Retinoid X Receptors During Human and Azoxymethane-induced Colorectal Carcinogenesis in the Rat
Background/Aim: The family of retinoid X receptors (RXRs) including RXRα, β and , is involved in regulating cell proliferation, differentiation, apoptosis and development. Materials and Methods: In order to characterize the role of RXRs during colorectal carcinogenesis, the expression of RXRs in human…
5h
The Contribution of Dental Implants to Functional Artificial Restoration After Treatment of Oral Cancer
Background/Aim: The aim of this study was to evaluate dental implants with regard to artificial restoration of oral function and quality of life in patients with oral cancer. Patients and Methods: We examined 134 implants in 41 patients who had undergone jawbone resection as treatment for oral cancer….
5h
Induction of Apoptosis by Functionalized Fullerene-based Sonodynamic Therapy in HL-60 cells
Ultrasound has been widely utilized for medical diagnosis and therapy due to its ability to penetrate deep-seated tissue with less attenuation of energy and minimal undesirable side-effects. Functionalized fullerenes, such as polyhydroxy fullerene (PHF), have attracted particular attention due to their…
5h
siRNA Targeting of MDR1 Reverses Multidrug Resistance in a Nude Mouse Model of Doxorubicin-resistant Human Hepatocellular Carcinoma
Aim: To investigate the effects of vector-based small interfering RNA (siRNA) targeting MDR1 on the reversal of multidrug resistance in a mouse model of doxorubicin (DOX)-resistant human hepatocellular carcinoma. Materials and Methods: Three siRNAs plasmid vectors (MDR1 siRNA1, MDR1 siRNA2 and MDR1 siRNA3)…
5h
Expansive Extracranial Growth of Intracranial Meningioma in Neurofibromatosis Type 2
The purpose of this report is to detail three rare cases of neurofibromatosis type 2 (NF2) with symptomatic extracranial extension of intracranial meningioma. We present ocular findings, imaging techniques applied, pathological findings of the space-occupying lesions, and therapy. One of these patients,…
5h
Immunology of the Skin. Basic and Clinical Sciences in Skin Immune Responses
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5h
Management of Metastatic Bone Disease Algorithms for Diagnostics and Treatment
Background: Bone is a frequent site of metastases in advanced cancer and is associated with significant skeletal morbidity. Current treatment options are aimed at preserving and improving functional independence and quality of life. Materials and Methods: A review of current literature focusing on diagnostic…
5h
Heterogeneity of Vascular Endothelial Growth Factor Receptors 1, 2, 3 in Primary Human Colorectal Carcinoma
Background: The vascular endothelial growth factor (VEGF) pathway plays an important role in growth and progression of human cancer, including colorectal carcinomas (CRC). The key mediators of VEGF signaling are VEGFR1, VEGFR2, and VEGFR3, part of a family of related receptor tyrosine kinases. The relative…
5h
Identification of ESE1 as a {beta}-Catenin Binding Protein
Background/Aim: β-Catenin regulates cell-cell adhesion and gene transcription and acts as a master switch that controls proliferation in several types of cancer. ESE1 is an epithelium-restricted transcription factor and its multiple domain structure predicts its interaction with other proteins with diverse…
5h
Depth of Hepatic Infiltration and Lymph Node Swelling as Factors for Considering Surgery for T2-4 Gallbladder Carcinoma Patients
Background/Aim: The aim of the present study was to clarify if the degree of hepatic infiltration and lymph node swelling of gallbladder carcinoma (GBC) should be held as deciding factors for T2-4 GBC patients to undergo surgery. Patients and Methods: Fifty consecutive patients with T2-4 GBC who underwent…
5h
Activation of the PERK-eIF2{alpha} Pathway Is Associated with Tumor-infiltrating Lymphocytes in HER2-Positive Breast Cancer
Background: We evaluated endoplasmic reticulum stress and unfolded protein response (UPR) activation, as possible mechanisms for influx of tumor infiltrating lymphocytes (TILs), and the correlation between UPR activation and mammalian target of rapamycin (mTOR) pathway activation. Materials and Methods:…
5h
Immunohistochemical Evaluation of the Role of p53 Mutation in Cervical Cancer: Ser-20 p53-Mutant Correlates with Better Prognosis
Background: Cervical cancer is driven by human papillomavirus virus-specific oncoprotein E6. E6 interacts with E3 ubiquitin-protein ligase, resulting in the proteolysis of p53 protein. The aim of this study was to analyze one TP53 mutation in patients with cervical cancer and to correlate it to prognosis….
5h
Chronomodulated oxaliplatin plus Capecitabine (XELOX) as a first line chemotherapy in metastatic colorectal cancer: A Phase II Brunch regimen study
Abstract Purpose The aim of this study was to evaluate safety and toxicity of chronomodulated capecitabine administered in the morning and at noon according to a specific time schedule (Brunch Regimen: Breakfast and Lunch) as a part of…
5h
[Comment] Lung cancer risk in new pulmonary nodules: implications for CT screening and nodule management
The Dutch-Belgian Randomised Lung Cancer Screen Trial (NELSON)1 of low-dose CT versus usual care has provided unique evidence about the risk of lung cancer in pulmonary nodules according to semiautomated measurement of the volume of a nodule, calculated diameter, and growth rate expressed as volume doubling…
5h
[Articles] Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT: analysis of data from the randomised, controlled NELSON trial
Our study shows that new solid nodules are detected at each screening round in 5–7% of individuals who undergo screening for lung cancer with low-dose CT. These new nodules have a high probability of malignancy even at a small size. These findings should be considered in future screening guidelines,…
6h
Chronomodulated oxaliplatin plus Capecitabine (XELOX) as a first line chemotherapy in metastatic colorectal cancer: A Phase II Brunch regimen study
Abstract Purpose The aim of this study was to evaluate safety and toxicity of chronomodulated capecitabine administered in the morning and at noon according to a specific time schedule (Brunch Regimen: Breakfast and Lunch) as a part of…
6h
Long non-coding RNA ATB promotes glioma malignancy by negatively regulating miR-200a
Glioma is one of the most common and aggressive primary malignant tumor in the brain. Accumulating evidences indicated that aberrantly expressed non-coding RNAs (ncRNAs), including long non-coding RNAs (lncRNA… from Cancer via xlomafota13 on Inoreader http://ift.tt/1UuWcQ6 via IFTTT
6h
Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool
Abstract Background Colorectal cancers (CRC) are associated with perturbations in cellular amino acids, nucleotides, pentose-phosphate pathway carbohydrates, and glycolytic, gluconeogenic, and tricarboxylic acid intermediates. A non-targeted…
7h
Reducing Anesthesia and Health Care Cost through Utilization of Child Life Specialists in Pediatric Radiation Oncology
Publication date: Available online 5 June 2016Source:International Journal of Radiation Oncology*Biology*Physics Author(s): Michael T. Scott, Kimberly E. Todd, Heather Oakley, Julie Bradley, Ronny Rotondo, Christopher G. Morris, Stuart Klein, Nancy P. Mendenhall, Daniel J. IndelicatoPurposeDuring…
7h
Rapidly Progressing Primary Extrahepatic Bile Duct Signet-Ring Cell Carcinoma in a Caucasian Woman
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9h
Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system
Abstract Answer questions and earn CME/CNE In this report, a team of surgical pathologists has provided a review of intraepithelial neoplasia in a host of (but not all) anatomic sites of interest to colleagues in various medical specialties, namely, uterine cervix, ovary, breast, lung, head and neck,…
9h
Military Metaphors and the Consequences of the Language of Cancer
Publication date: Available online 6 June 2016Source:Practical Radiation Oncology Author(s): Edward C. Halperin from Cancer via xlomafota13 on Inoreader http://ift.tt/1Xy0fCj via IFTTT
10h
Associations between metabolic syndrome, breast cancer recurrence, and the 21-gene recurrence score assay
Abstract The 21-gene recurrence score (RS) assay is prognostic in estrogen receptor-positive (HR+), HER2-negative, node-negative breast cancer (BC). The interaction between RS and host factors including metabolic syndrome (MS) is unclear. MS conditions such as obesity have been associated…
10h
Time trends in incidence rates and survival of newly diagnosed stage IV breast cancer by tumor histology: a population-based analysis
Abstract Few contemporary data are available that compare incidence and survival of metastatic breast cancer between ductal and lobular carcinomas. Using the Surveillance, Epidemiology, and End Results-9 registries, we identified 10,639 patients with de novo metastatic breast cancer…
10h
[Articles] Quality of life in patients with advanced renal cell carcinoma given nivolumab versus everolimus in CheckMate 025: a randomised, open-label, phase 3 trial
Nivolumab was associated with HRQoL improvement compared with everolimus in previously treated patients with advanced renal cell carcinoma. from Cancer via xlomafota13 on Inoreader http://ift.tt/1PeNap2 via IFTTT
10h
Long-term cardiovascular outcomes and overall survival of early-stage breast cancer patients with early discontinuation of trastuzumab: a population-based study
Abstract We critically examined long-term cardiovascular (CV) outcomes and overall survival (OS) of breast cancer (BC) patients who had cardiotoxicity during adjuvant trastuzumab treatment requiring discontinuation in a population-based sample. This was a retrospective cohort of early-stage…
10h
[Comment] Improved quality of life is the way to longer life
In The Lancet Oncology, David Cella and colleagues1 report the quality-of-life results from the previously published Checkmate 025 trial.2 The original study, which included patients with advanced renal cell carcinoma previously treated with antiangiogenic therapies, showed that nivolumab was superior…
10h
Risk of biochemical recurrence and timing of radiotherapy in pT3a N0 prostate cancer with positive surgical margin
Abstract Background Despite improved biochemical recurrence-free survival rates by the use of immediate adjuvant radiotherapy (RT) in patients with locally advanced prostate cancer, disagreement about the need and timing of RT remains….
10h
Protonentherapie bei Kindern mit Medulloblastom bei akzeptablen Nebenwirkungen ähnlich erfolgreich wie Photonentherapie
from Cancer via xlomafota13 on Inoreader http://ift.tt/213F4FW via IFTTT
10h
Neoadjuvant chemoradiotherapy of rectal carcinoma
Abstract Background The link between the blood count and a systemic inflammatory response (SIR) is indisputable and well described. Pretreatment hematological parameters may predict the overall clinical outcomes in many types of cancer….
10h
Capacitabine und Oxaliplatin (XelOx) im Vergleich zu Fluorouracil/Folinsäure als adjuvante Therapie bei Kolonkarzinomen im Stadium III: Ergebnisse der kontrollierten randomisierten Phase III-Studie NO16968
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11h
OLA1 gene sequencing in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer
Abstract Background Of individuals with suspected hereditary breast and ovarian cancer (HBOC), approximately 30–70 % do not harbor mutations in either BRCA1 or BRCA2 gene, which suggests that these individuals have other genetic or epigenetic…
12h
A Systematic Review: Childhood Cancer Survivors and Gastrointestinal Cancer
Publication date: Available online 6 June 2016Source:Cancer Treatment Reviews Author(s): Isabel Griffin, Purnima Madhivanan from Cancer via xlomafota13 on Inoreader http://ift.tt/1t2a6D3 via IFTTT
13h
Serum microRNA panels as potential biomarkers for early detection of hepatocellular carcinoma on top of HCV infection
Abstract The identification of new high-sensitivity and high-specificity markers for hepatocellular carcinoma (HCC) is essential. We aimed at identifying serum microRNAs (miRNAs) as potential biomarkers for early detection of HCC on top hepatitis C virus (HCV) infection. We investigated…
14h
[Articles] Dabrafenib plus trametinib in patients with previously treated -mutant metastatic non-small cell lung cancer: an open-label, multicentre phase 2 trial
Dabrafenib plus trametinib could represent a new targeted therapy with robust antitumour activity and a manageable safety profile in patients with BRAFV600E-mutant NSCLC. from Cancer via xlomafota13 on Inoreader http://ift.tt/1PesygF via IFTTT
14h
[Comment] Combined BRAF and MEK inhibition in -mutant NSCLC
In the past two decades many of the molecular drivers of non-small-cell lung cancer (NSCLC) have been elucidated and therapies targeting these changes have offered new hope and improved survival for patients. In NSCLC, these treatments have been honed in the treatment of EGFR-mutated and ALK-mutated…
14h
PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions
PPAR-delta promotes survival of breast cancer cells in harsh metabolic conditions Oncogenesis 5, e232 (June 2016). doi:10.1038/oncsis.2016.41 Authors: X Wang, G Wang, Y Shi, L Sun, R Gorczynski, Y-J Li, Z Xu & D E Spaner from Cancer via xlomafota13 on Inoreader…
14h
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway
NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway Oncogenesis 5, e231 (June 2016). doi:10.1038/oncsis.2016.39 Authors: C L Duran, D W Lee, J-U Jung, S Ravi, C B Pogue, L G Toussaint, K J Bayless & R Sitcheran…
14h
Pharmacokinetic profiles of significant adverse events with crizotinib in Japanese patients with ABCB1 polymorphism
Summary Crizotinib is a standard treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC). We conducted this study to investigate the pharmacokinetics of crizotinib and clinical and pharmacogenomic factors that may increase the risk of adverse events (AEs). We defined clinically significant…
14h
HIF-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model
Abstract Pancreatic cancer is one of the most lethal digestive system cancers with a 5-year survival rate of 4%–7%. Despite extensive efforts, recent chemotherapeutic regimens have provided only limited benefits to pancreatic cancer patients. Gemcitabine and TS-1, the current standard-of-care chemotherapeutic…
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Assessment of gamma radiation exposure of beach sands in highly touristic areas associated with plutonic rocks of the Atticocycladic zone (Greece)
Today, 7 Ιουνίου 2016,
7 hours ago | Alexandros Sfakianakis
Publication date: October 2016
Source:Journal of Environmental Radioactivity, Volumes 162–163
Author(s): A. Papadopoulos, A. Koroneos, G. Christofides, L. Papadopoulou, I. Tzifas, S. Stoulos
This study aims to evaluate the activity concentrations of 238U, 226Ra, 232Th, 228Th and 40K along beaches close to the plutonic rocks of the Atticocycladic zone that ranged from 15 to 628, 12-2292, 16-10,143, 14-9953 and 191-1192 Bq/kg respectively. A sample from island of Mykonos contained the highest 232Th content measured in sediments of Greece. The heavy magnetic fraction and the heavy non-magnetic fraction as well as the total heavy fraction, were correlated with the concentrations of the measured radionuclides in the bulk samples. The heavy fractions seem to control the activity concentrations of 238U and 232Th of all the samples, showing some local differences in the main 238U and 232Th mineral carrier. Similar correlations have been found between 238U, 232Th content and rare earth elements concentrations. The measured radionuclides in the beach sands were normalized to the respective values measured in the granitic rocks, which at least in most cases are their most probable parental rocks, so as to provide data upon their enrichment or depletion. Since the Greek beaches are among the most popular worldwide the annual effective dose equivalent received due to sand exposure has been estimated and found to vary between 0.002 and 0.379 mSv y−1 for tourists and from 0.018 to 3.164 mSv y−1 for local people working on the beach. The values corresponding to ordinary sand samples are orders of magnitude lower than the limit of 1 mSv y−1, only in the case of heavy minerals-rich sands the dose could reach or exceed the recommended maximum limit.
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Intraoperative Detection of Small Tumors of the Parotid Gland
Today, 7 Ιουνίου 2016,
7 hours ago | Alexandros Sfakianakis
Charcoal Suspension Tattoo: A New Technique
for Intraoperative Detection of Small Tumors of the Parotid Gland:
Objective:
The current surgical trend in the treatment of pleomorphic adenomas of the parotid gland is to limit the extent of resection. This raises the need to correctly identify the mass within the normal parenchyma so as to avoid dissecting the entire superficial lobe of the gland. We describe ultrasound-guided tattooing as a technique to facilitate identification and excision of parotid pleomorphic adenomas.
Methods:
We reviewed 23 consecutive patients with pleomorphic adenoma of the parotid gland. All patients underwent ultrasound-guided tattooing of the lesions with a charcoal suspension. Baseline tumor and patients’ characteristics, major and minor complications, and subjective tolerance to the procedure were recorded. We assessed the number of intralesionally marked masses and the percentage of intraoperatively detected marked lesions.
Results:
The injection was well tolerated. No major complications were recorded. In 2 cases (9%), a transient increase in lesion size was observed. No other minor complications were encountered. Charcoal was found inside the tumor in 19 cases (83%). In 4 cases (17%), it was found in the tissues above the lesion. Twenty-three lesions were intraoperatively detected (100%) and dissected.
Conclusion:
Charcoal suspension tattooing is safe and well tolerated for the detection of small pleomorphic adenomas during parotid surgery.
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The current surgical trend in the treatment of pleomorphic adenomas of the parotid gland is to limit the extent of resection. This raises the need to correctly identify the mass within the normal parenchyma so as to avoid dissecting the entire superficial lobe of the gland. We describe ultrasound-guided tattooing as a technique to facilitate identification and excision of parotid pleomorphic adenomas.
Methods:
We reviewed 23 consecutive patients with pleomorphic adenoma of the parotid gland. All patients underwent ultrasound-guided tattooing of the lesions with a charcoal suspension. Baseline tumor and patients’ characteristics, major and minor complications, and subjective tolerance to the procedure were recorded. We assessed the number of intralesionally marked masses and the percentage of intraoperatively detected marked lesions.
Results:
The injection was well tolerated. No major complications were recorded. In 2 cases (9%), a transient increase in lesion size was observed. No other minor complications were encountered. Charcoal was found inside the tumor in 19 cases (83%). In 4 cases (17%), it was found in the tissues above the lesion. Twenty-three lesions were intraoperatively detected (100%) and dissected.
Conclusion:
Charcoal suspension tattooing is safe and well tolerated for the detection of small pleomorphic adenomas during parotid surgery.
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